>ENSIPUP00000037538 MNLHQVLTGAVNPGDNCFSVGSINNVPFTAYASGCDIVILGSDFERLQIIPGAKHGNIQV ACVDCSQQG-Q------------------------------------------------- ------------------------------------------------------------ ------IAASYGNIVCIFDPVLMS-PKEKMLM----------------------KLNYHW QKTGQFVLQSIAHNIAWSPT---------------------------------------- ------------------------------------GSS-LLTGSSCLQLWSS------- --------V---------------------NFCAGAEEEMGND----------------- ------------PL---------------------------------------------- -----------------SSWRC-----------IW------------------------- --QFKTASPVHLIKFSPDGEFFATAG---------------QDDCLVKVWYSTRKWQSDA TKLFTPPE--LNSQGKPDFSFIYLAHPRSVTGFSWRKTSKYIP-R--------------- ---------------------------------------G--------------AVCSVL LTCCKDSVCRLWAETLLPSDCLLSGLRQN------------------------------- --------------------------HSSSTNDAVKSSNIKKAHYNNKELNRGPVRGMAH AR---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------PLPQQQNK -HYTHRAT------IA-HTNALCHFHIAASINPATDIPLLPSISSLNSSDDEEPGGPFNV HWLNNKELHLTLTMEVFLQQFRSNLEH--------------------------------- ------------QKP-----------------------------PQASQADDGN------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------C--------------------- --------DEEGNTISPESKKGETSFKDGASIP--------------------------- ---------------------------------------------------------LPK AAVNHQVEVLLNDWNRGADMLFSIHSMDGSLLVWHVDWLDEYQPGMFRQAQVSFASRIPV AFPTGDAISLSRSIVMYACNKNVDLAIQHGRQ----HPQ-GLQRSSSVLI---------- -------------------------------------------GLGQGKQCPNGLRLSIF TPNVLMISKHSDGSLNQWSVSFAEGSAFSTVLSVSHKSRYCGHRFHLNDLACHSVLPLLL TTSHHN-------------------------A---------------------------- ----------------------------------------------------KVCN---- ------------------PIAY-------SGPGPVSS----------GQRNRSSLGAVSQ DPNAIYSELILWRVDPVGPLSFSGGVSELARINSLHASAFSNVAWLPTLIPSNCL--GVY GNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPEISVSIFKIIDFSDKRKNLTLHLFC ------------------------------------------------------------ ------------------QGKETQLLHVFEVDLILG------------------------ --------------------------------------NE-------------------- ----------------------------------------------K------------- -----------------------------------DD---------SSG----------- ------LS-----LFWARFFLVVIEFTQSRRSVLHMW----------------------- --------------------------------HLQLAAA--------------------- ------------------------------------------------------------ ------------------------------------------------P----------- ----------------------------------------FFHLEMMALTVVLWNPVSSS FISNLQNDSPSPHKSP-------------------------------------------- ------------------------------------------------------------ --------------------LSRSNLRSACRLTLAKERVFSQELTLPEGVEVISATPAAG HLSSSSLQPTGRAPYLLATSCTDGTVRFWSCRVVSDN-------------DKTLDASP-- -----------YIWEEWPLLVEEDLANSSAVNIPDKPVGISCCHTSRVAVAY-------- ---------RES-------KPSRLA----------------------------------- ------------------------------------------------------------ ------------------------------KKPI-----------------------IH- --------------------------VSIFQCESTGGSQWILEQTLELDVSNSLTNNGSD ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KQLLVPSFQDGLVSTG------------------------------ -------DCLHSSGKTLVHLDWVSREDGSHILTVGLGSKLYMYGLLSGKPPELGL-SDNS REHC----SSRLVLLRVVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPA- ------------------------------------------------------------ ------------------------------------------------------------ -ALAK------------------------------------SALTVGDANGGSMN----- ---------------------SLSTALKQEGLSLQP------------------------ -------------------SKKTLTRSMTSLAQKLS---GKRTM-YALPAEMEDYGLFEA AHHLFPTLPQYHPVQLLELMALGKVRRAKAILSHLVKCIAGEIVTLKDTS-V-------- ---NQERRLRSLTIS---ASGITSRDPKMFNK-TES--SDYTEIDSIPPLPLYALLAAD- DDTAHCA----KVKT-----------SSVSGD-----------------SGHGSS----- ------------------------------------------RADTYDELFQTSPVSLDD --------------------MDLL-DGEEEDSKA-------------------------- --------------------------------------KVIDLSKYGPTFFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTVASTSTDIRESQGK----ETLDECGLKFLLAVRLH TFLLTSLPPVHRAQLLCQG-------------LSTCHYIWAFHSEAEEELLNMLPCMQKG EPTWPELKAMGVGWWLRSTNKLRRCIEKVAKASFQKSNDPLDAALFYLAMKKKAVVWGLY RSHRNVKMTAFFSNNFNEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLRDAVEVCLE KMQDLQLALVISRLYESEFETSSTYKKVLQR------------YVLGHDHQ--------- ----------------------------------IPMHQDPFLRSMAYWVLDDYSRALDT LLEE---------PTP-------------------------NVDALHQE----------- -------------S--------------------------------------------SP CNP---------------------EVFNFYTYLKTHPLLLRRHFGSSE---KAKVG---- ------LTGQGSMADSISLVERRLFFTTANAHLQAGCPMLALEILSKMPKVIKKSKM--- -------------LHNQDKPSPTFSGP--------------------------------- ------------------------------------------------------------ -------------------------DNPDCESGKDQ----------------------AS TLDWSQPTLNGFGSVSD---TLSSPQEDHSHSDSVLSFDWSQLSMTLQDEPLELKWDSDK EE---SE-DE--------------------------------------VAGLAMKRIKPE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SSAVLCDAPDSTSMSTD VTVDNS----PFLFE--------------------------------------------- --------DIFAARFKFISCLKMLTAELRTLSTGYELDGGKLRHQLCHWLERE------- ---------------------V-------------------------------------- VALQKCCGYNPYLQQV-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AGGIS----------------------V ELGQ--VSGTSGDEQEYQGTAEQVREVQ-----------------------------HR- ---------RRLWLQRN----QPLLRIFLSYCGLHGSHGGGLASVRMELILLLQESQ--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSFQ---- ------------------------VAVQQ------------------------------- ------------------------------------------------------------ -QASVPLLLACTASSKTVVANPIVHLTNLTHDILHTINALDSPPHPDVVNNEIYVMHSLA ASLSACIYQCL----CDGHSY-------------------------------------S- --HINQFTGTVYE--------------SILLSHQHPVRNLSMDEAVIPNTSPAKWPG--- -----VSTLVRLLG-AAAEENQPGVGVLLCEILTAVFFSLFVHGLATHSSNELFHIVAHP LNNKLWVAVFGGGA---------------------------------------------- ------------------------------------------------------------ ------------------------------------LSKRTIFSNDTLLCVLAPAPMEDQ EFKQKRFRLHSSRSSSRE----------------------VPDNPV--S--P-SPIVE-- --------------------------------QE-ASIFKERFVPPELSIWDYFIAKPFL PPSVSGVEYDSEESQGS--D--EEE----EDD-----D-AFGDEFDSNSPLQEHSNNNSY SWCLMRLAMVQLVLGNFKSFYPMAGYDLLDLPVCSPLCHSVMKTLQRWEQVLLKRLEIFG GPPSKYISTHPVDGTMASGLALLRHKALFEPSNTPFRSRRHSALSVKRLWQYLVKQEEVQ ETFIRNIFTKKQDQ---------------------KE-------------------IEAD LGYPAGKARIIHKESDIITAFAINKANRNCLVIASTHDIQELDVSSILATQILTWIDDDT DMEVK----GDDFLVVQTRDDFTTLHGTTPYTHSSPGTPINMPWLGSHQTGRGAA----M LIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVMRIRFNYQ GNKFGIVDADGALSLWQTNTSGNTPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVMPSNSLVH--------------------GFSCHESGATVLALAPKQQLL LSGGRKGWISVLDLTLKLQRQSFQAHDSAVKALAVDGTEGCFISGSAEGNIKVWNMFTQC LLHTFPNEHARQSIFRNLGTGVMQIETAPGNHIFSCGADGTMKMRVLPDHV--------- ---SS-----------------YTNNVKNDVKFII >ENSPNAP00000002433 MNLHQVLTGAVNPGDNCFSVGSINNVPFTAYASGCDIVILGSDFERLQIIPGAKHGNIQV GCVDCSQQGG-------------------------------------------------- ------------------------------------------------------------ -------------------------------QFIV------TTRFTVMTLFAFLKLNYHW QKTGQFVLESIAHNLAWNPT---------------------------------------- ------------------------------------GTRVLLTGSGCLQLWSN------- --------V---------------------NFCFSAEGETSSD----------------- ------------PP---------------------------------------------- -----------------CSWRC-----------IW------------------------- --QCKTASPIQLMKFSPGGEFFATAG---------------QDDCLVKVWYSTSKWQSDA VKLFSPPE--LGSQGEMDFSFIYLAHPRAVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPSDCLLSGLRHN------------------------------- --------------------------HSSS------------------------------ ------------------------------------------------------------ -------------------------------NNSDALKSNN------------------- ------------------------------------------------------MKKVCS KMLVCSVYFTQLNLTESWRGP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------IRCAAQLSHTGLLPHQQNK -HYTHRAI------TP-HANALCHFHIAASINPATDIPLLPSISSLSGSDEEEPGGPFTV HWLNNKELHLTLTMEVFLQQIRSSLEQ--------------------------------- ------------QNQ-----------------------------PQASQADE-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------DFDEEGNAVSPEDKKGEVNI-DAASIP--------------------------- ---------------------------------------------------------LPK AAVEHQVDVLLGDWNRGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQAQVSFVSRIPV AFPTGDANSLSRSVVMYACNKNVDLAIQHGRQ----RPA-GLPRSSSVLI---------- -------------------------------------------GLGQSKPCSNSLRLSIF TPNVLMISKHADGSLNQWAVSFAEGSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEVENILA--------------------------------QSL-------- -------------------------------PGPASS----------GRKTRATLSAVSQ DPNAIYSELILWRVDPVGPLSFSGGVSELARINSLHASAFSNVAWLPTLIPSNCL--GVY GNSPSACFVASDGHFLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTARPGCIIELDAITD--------------------F------------ ------------------V-RTIQLLHVFEEDLILG------------------------ --------------------------------------NE-------------------- ----------------------------------------------K------------- -----------------------------------ND----------------------- -------EFSSPVLFSARFFLVVIEFTQSRRSLLHMW----------------------- --------------------------------HLQ------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LTSTPVDKDTSAS SAINN-------------------------FNFESFS------------------SPSSQ R-----------------SKLSRSNLRSACRLTLTNERVFSQELSLPEGVEVIRVTPAAG HLSSSSLQPAGRAPYLLATSCSDGTVRFWSCSTASDN-------------D------ASD EIAP------TYFWEEWPLLVEEGLANTSAVSVPGWPVGVSCCHTSRVAVAY-------- ---------KDL-------KPQGLA----------------------------------- ------------------------------------------------------------ ------------------------------KEPL-----------------------IH- --------------------------VSLFQCESTGGSQWMLEQTLKVDSWGSIPNNASD KHLIV------------PNFQDGLVGHKDCLG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------TSG-------------------- ------------------------------------------------------------ --------------KSLVHLDWVSREDGSHILTVGLGSKLYMYGPLLGKPPELGL-SDST RECC----SSRLVLLRVVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APAK------------------------------------SALTTCDTNVGSVS----- ---------------------SLIAAVRQEAVSLQP------------------------ -------------------PKKTLTRSMTSLAQKLS---GKRTM-YDLPAEMEDYGLFET AHHLFPTLPQYHPVQLLELMDLGMVRRAKAILSHLVKCIAGEIVALKDTS-I-------- ---NQERRLRSLTIS---ASGSTARDPRMFNK-AEN--PDYTEIDSIPPLPLYALLAAD- EETTPKA----KDKA-----------ASISGD-----------------SGHSSS----- ------------------------------------------RTDTYDELFQATTISMDD --------------------VDPL-DGEEDDSNA-------------------------- --------------------------------------KVIDLSQYSPTFFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIASTSTDIGESQGKSQGGETLDECGLKFLLAVRLH TFLLTSLPPAHRAQLLCQG-------------LSTCHYAWAFHSEAEEELLNMLPAMQKG EPAWPELRGMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAALFYLAMKKKAVVWGLY RSHKNVKMTAFFSNNFNEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETSSTYKKILQR------------YVLGQDHQ--------- ----------------------------------IPMHQDPFLRSMAYWVLDDYSRALDT LLEQ---------PNP-------------------------NVDALNQG----------- -------------TTAV-----------------------------------------SP CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSD---KAKVG---- ------LTAEGRMADSVSLIERRLFFTAAYAHLQAGCPMLALEVLSKMPKVVKRSKL--- -------------LLTLEKPSPSFSGS--------------------------------- ------------------------------------------------------------ -------------------------GNSAGQNGKDQ----------------------AS ALDWSQPMLNGLESISD---TFSSPREDHSQSDSVLSFDWSQPSMTLQDEPLDLKWDSDK ED---SE-DE--------------------------------------EAGLAMKNIKPE DSTVIPDCADSTSASTDVVDSSLLL----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------S---------------- --------------E--------------------------------------------- --------DILAARLKFSSCLKILTAELRTLSTGYELDGGKLRHQLCHWLERE------- ---------------------V-------------------------------------- VALQRCCGYNPCLHQL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------VGGIS----------------------A DLSQ--VGG-SEDEQEAQGAAEQARAVQ-----------------------------HR- ---------RRLWLKRN----QPLLRIFLSYCSLHGSHGGGLASVRMELILLLQESQ--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSPQ---- ------------------------LPVQQ------------------------------- ------------------------------------------------------------ -QALVPLLLACTASSKTVVANPIVHLTNLTHDILHIINALDSPPHPDVINNEIYVMHTLA ASLSACIYQCL----CDSHNY-------------------------------------S- --HINQFTGTVYQ--------------SILLSHQHPVRTISMDEAVLPNTSPAQWPG--- -----ISALVRLLS-AAGEENQPSLGVLLCEILTAVYLSLFVHGLATHSSNELFRIVAHP LNSKLWVAVFGGGARIP------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -RKQRRFRMLSSRSSSRE----------------------VPDSPASPS--P-SPIVE-- --------------------------------QE-ASVFKERFVPPELSIWDYFIAKPFL PPSASCVEYDSEESQESE-D--EDE----EEE-----D-KFADAFDTNSPLEEHSSNNSY SWCLMRLAMVQLVMVNLKSFYPMAGHDLLDLPVCSPLCHSVLKTLQRWEQVLLKRLEIFG GPPSQYISTQPTDDTMASGPALLRHKALFEPSNTPFRSRHHSALPVKRLWQYLVKQEEVQ ETFIRNIFTKKRDQ---------------------NE-------------------IEAD LGYPGGKARIIHKESDIITAFAINKANRNCLVIASTHDIQELDVSSILATQILTWVDDEA ETEVK---GGDDFLVVHARDDFSTLHGTTPYTNSSPGTPINMPWLGSLQTGRGAA----M LIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQITCFRSPGNSRVTRIRFNYQ GNKFGIVDADGALSLWQTNTSGNTPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCVWDTLVPPTNSLVH--------------------GFSCHESGATVLALAPKQQLL ISGGRKGWISVLDLTQKLQRQSFQAHDSPVKALAVDATEGYFISGSAEGNIKVWSMSTQF LLHTFPNEHARQSLFRNLGTGVMQIESAPGNHVFSCGADGTMKMRVLPDCF--------- ---RT-----------------YSNNMKNDVRFIM >ENSAMXP00005040823 MNLHQVLTGAVNPGDNCFSVGSINNVPFTAYASGCDIVILGSDFERLQIIPGAKHGNIQV GCVDCSQQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGNIVCIFEPVQIS-PKEKRQQ----------------------KLNYHW QKTGQFILQSIAHNLAWRPT---------------------------------------- ------------------------------------GGS-LLTGSNCLQLWSN------- --------V---------------------NFSCGANGETSTI----------------- ------------PP---------------------------------------------- -----------------CSWRC-----------IW------------------------- --QSKTASPIHLMKFSPGGEFFATAG---------------QDDCLVKVWYNTSKWQTDA MKLFTPPE--LSSQGEIDFSFIYLTHPRAVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPSDCLLSGLRHNHT----------------------------- -----------------QCS----FFH--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LNLNESWRGP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VRCTAQPAHTGLLPHQQNK -HYTHRAS------IP-HANALCHFHIAASINPAT------------------------- ------------------------------------------------------------ ----------------------------------------------------GNYSI--- -----------------------------------PEF---------------------- -------------------------------------TLTTLSGSH-------------- --------PFTTHLPV---------------------SCA----------SPVTFNISSR VILYIAEFDEEGNAVNPEGRKGEMNM-DAGSIP--------------------------- ---------------------------------------------------------LPA AAVEHQVDVLLGDWNRGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQAQVSFVSRIPV AFPTGDANSLSRSVVMYACNKNVDLAIQHGRQ----RPP-GLPRSSSVLI---------- -------------------------------------------GLGQSKPSSNSLRLSIF TPNVLMISKHADGSLNQWAVSFAEGSAFSTVLSVSHKSRYCGHRFHLNELACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPQAENILT--------------------------------QSL-------- -------------------------------PSPVSS----------GRKSRSSLGAVTQ DPNAIYSELILWRVDPVGPLSFSGGVSELARINSLHASAFSNVAWLPTLIPSNCL--GVY GNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPEISK--------------------C VGEVFNIISQQSTARPGCIIELDAITD--------------------F------------ ------------------QGKEIQLLHVFEEDLILG------------------------ --------------------------------------NE-------------------- ----------------------------------------------KKE----------- ----DC-----SQESLPDETAS---------SPPV------------------------- --------------FTARFFLVVIEFTQTRRSLLHMW----------------------- --------------------------------HLQ------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LTSTPVDKDTVA- SPLNS-------------------------FNFETFS------------------SPSSQ R-----------------SKLSRTNLQSACRLTLTNERVYSEELSLPEGVEVLRVTPAAG HLSSSSLQPAGRAPYLLATSCSDGTVRFLSCSTASDS-------------D------TAD DTAS------IYIWEEWPLLVEEGLANSSAVSIPGWPVDVSCCHTSRVAVAY-------- ---------KDL-------KPQGLG----------------------------------- ------------------------------------------------------------ ------------------------------MEPP-----------------------IH- --------------------------VSVFQCESTGGSQWMLEQTLKLD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GLSSL---------------- -------PKNGSDDKHLIVPSLQDDLVDAG------------------------------ -------ECLGSSCKTLVHLDWVSREDGSHILTVGLGSKLYMYGTLLGKPPELGL-SDSS RERC----SSRLVLLRVVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -TPPK------------------------------------SALATCDTVVGSVS----- ---------------------SLIAAVKQEGLNLQP------------------------ -------------------PKKSLTRSMTSLAQKLS---GKRTM-YDLPVEMEDYGLFEA AHHLFPTLPQYHPVQLFELMDLGKVRRAKAILSHLVKCIAGEIVALKDTA-I-------- ---NQERRLRSLTIS---ASGSTARDPRMFNK-AEN--PDYTEIDSIPPLPLYALLAAD- EDTTPKA----KEKA-----------SSVSGD-----------------SGHGSS----- ------------------------------------------RTDTYDELFQATAVSLDD --------------------VDPL-DGDDEDSNA-------------------------- --------------------------------------KVIDLSQYSPTFFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIASTSTDIGESQGKSQGGETLDECGLKFLLAVRLH TFLLTSLPPAHRGQLLCQG-------------LSTCHYAWAFHSEAEEELLNMLPAMQKG DPTWPELRAMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAALFYLAMKKKAVVWGLY RSHKNVKMTAFFSNNFNEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETSSTYKKILQR------------HVLGQDHQ--------- ----------------------------------IPMHQDPFLRSMAHWVLDDYSRALDT LLEQ---------PKP-------------------------NVNASNQE----------- -------------KSAM-----------------------------------------SP CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSE---KAKVG---- ------LTAEGRMADSISLIERRLFFTAANAHLQAGCPMLALEVLSKMPKVVKKSKL--- -------------LLNQEKPSLSSTGS--------------------------------- ------------------------------------------------------------ -------------------------GNPAGEKGKDQ----------------------AS ALDWSQPTINGFESISD---TLSSPREDHSQSDSLLSFDWSQPSVTLQDEPLELKWDSDK ED---SE-DE--------------------------------------EAGLAMKNIKPE DTTVIHESADSASVSTDVTDSSLLL----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------S---------------- --------------E--------------------------------------------- --------DILVARLKFSSCLKVLTAELRTLSTGYELDGGKLRHQLCHWLERE------- ---------------------V-------------------------------------- VALQSCCGYNPYLQQL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AEGIS----------------------A DLSQVRVG----DEQETQGAAEEARVVQ-----------------------------RR- ---------RRLWLQRN----QPLLRIFLSYCSLHGSHGGGLASVRMELILLLQESQ--- ---------------------QV------------------------------------- ------------------------------------------RSISNTQTS--------- ------------------------------------------------------------ ------------------------------------------------------------ ----VPLLLACTASSKTVVANPIVHLTNLTHDVLHTINSLDSPPNPDVINNEIYVMHMLA ASLSACIYQCL----CDGHNY-------------------------------------S- --HINQFTGTVYQ--------------SILLSHQHPVRTLSMDEAVLPNTSPAQWPG--- -----ISALVRLLS-AAGEENQPSLGVLLCEILTAVYLSLFVHGLATHSSNELFRIVAHP LNSKLWVAVFGGGARIP------------------------------------AVEKSS- ------------P----------------------------------PPGCALLLPVTVC FPCMCVFVPAV---------AED------------------------------------Q ERKQRRFRLRSSRSSSRE----------------------VPDGPASPG--P-SPIVE-- --------------------------------QE-ASIFKERFVPPELSIWDYFIAKPFL PPSTSRVEYDSEESQGSE-D--EEE----EDE-----D-KFADAFDTNSPLQEHSNSNSY SWCLMRLAMVQLVLVNLKSFYPMAGHDLMDLPVCSPLCHSVLKTLQRWEQVLLKRLEIFG GPPSKYISTQPMDETIASGPALLRHKALFEPSNTPFRSRHHSALPVKRLWQYLVKQEEVQ ETFIRNIFTKKRDQIESVEDYTDSMKYSGKEEPGLNQ-------------------IEAD LGYPGGKARIVHKESDIITAFAINKANRNCLVIASTHDIQELDVSSILATQILTWIDDEP ETEVK---GGDEFLVVQARDDFSTLHGTTPYTHSSPGTPINMPWLGSLQTGRGAA----M LIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNYQ GNKFGIVDADGALSLWQTNTSGNTQKPYL--TLQCHNKTAHDFVFVGSSSLIATAGISTD NRNVCLWDTLVPPTSSLVH--------------------GFSCHESGATVLALASKQQLL ISGGRKGWISVLDLTQKLQRQSFQAHDSPVKALAVDSTEGCFISGSSEGNIKVWSMSTQS LLHTFPNEHARQSLFRNLGTGVMQIETAPGNHIFSCGADGTMKMRVLPDCL--------- ---SA-----------------YSNNVKNDVKFIM >ENSAMXP00000013125 MNLHQVLTGAVNPGDNCFSVGSINNVPFTAYASGCDIVILGSDFERLQIIPGAKHGNIQV GCVDCSQQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGNIVCIFEPVQIS-PKEKRQQ----------------------KLNYHW QKTGQFILQSIAHNLAWRPT---------------------------------------- ------------------------------------GGS-LLTGSNCLQLWSN------- --------V---------------------NFSCGANGETSTI----------------- ------------PP---------------------------------------------- -----------------CSWRC-----------IW------------------------- --QSKTASPIHLMKFSPGGEFFATAG---------------QDDCLVKVWYNTSKWQTDA MKLFTPPE--LSSQGEIDFSFIYLTHPRAVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPSDCLLSGLRHN------------------------------- --------------------------HSSSS----------------------------- -SS--------------------------------------------------------- ----------------------------SSGNSSD------------------------- ------------------------------------------------------------ -----------LNLNESWRGP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VRCTAQPAHTGLLPHQQNK -HYTHRAS------IP-HANALCHFHIAASINPATDIPLLPSISSLSGSDEEEPGGPFTV HWLNNKELHLTLTMEVFLQQLRSSMEQ--------------------------------- ------------QNH-----------------------------SQANQADD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------EGNAVNPEGRKGEMNM-DAGSIP--------------------------- ---------------------------------------------------------LPA AAVEHQVDVLLGDWNRGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQAQVSFVSRIPV AFPTGDANSLSRSVVMYACNKNVDLAIQHGRQ----RPP-GLPRSSSVLI---------- -------------------------------------------GLGQSKPSSNSLRLSIF TPNVLMISKHADGSLNQWAVSFAEGSAFSTVLSVSHKSRYCGHRFHLNELACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPQAENILT--------------------------------QSL-------- -------------------------------PSPVSS----------GRKSRSSLGAVTQ DPNAIYSELILWRVDPVGPLSFSGGVSELARINSLHASAFSNVAWLPTLIPSNCL--GVY GNSPSACFVASDGRSLRLYQAVIEAKKLLSELSNPEISK--------------------C VGEVFNIISQQSTARPGCIIELDAITD--------------------F------------ ------------------QGKEIQLLHVFEEDLILG------------------------ --------------------------------------NE-------------------- ----------------------------------------------KKE----------- ----GC-----SQESLPDETAS---------SPPV------------------------- --------------FTARFFLVVIEFTQTRRSLLHMW----------------------- --------------------------------HLQLAAV--------------------- ------------------------------------------------------------ ------------------------------------------------PVA--------- ------------------------------------------------------------ ---------------IGLYCLLRFLR----------------FYIIYL------------ ----------------------------------TFS------------------SPSSQ R-----------------SKLSRTNLQSACRLTLTNERVYSEELSLPEGVEVLRVTPAAG HLSSSSLQPAGRAPYLLATSCSDGTVRFLSCSTDSDS-------------D------TAY DTAS------IYIWEEWPLLVEEGLANSSAVSIPGWPVDVSCCHTSRVAVAY-------- ---------KDL-------KPQGLG----------------------------------- ------------------------------------------------------------ ------------------------------MEPP-----------------------IH- --------------------------VSVFQCESTGGSQWMLEQTLKLD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GLSSL---------------- -------PKNGSDDKHLIVPSLQDDLVDAG------------------------------ -------ECLGSSCKTLVHLDWVSREDGSHILTVGLGSKLYMYGTLLGKPPELGL-SDSS RERC----SSRLVLLRVVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -TPPK------------------------------------SALATCDTVVGSVS----- ---------------------SLIAAVKQEGLNLQP------------------------ -------------------PKKSLTRSMTSLAQKLS---GKRTM-YDLPVEMEDYGLFEA AHHLFPTLPQYHPVQLFELMDLGKVRRAKAILSHLVKCIAGEIVALKDTA-I-------- ---NQERRLRSLTIS---ASGSTARDPRMFNK-AEN--PDYTEIDSIPPLPLYALLAAD- EDATPKA----KEKA-----------SSVSGD-----------------SGHGSS----- ------------------------------------------RTDTYDELFQATAVSLDD --------------------VDPL-DGDDEDSNA-------------------------- --------------------------------------KVIDLSQYSPTFFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIASTSTDIGESQGKSQGGETLDECGLKFLLAVRLH TFLLTSLPPAHRGQLLCQG-------------LSTCHYAWAFHSEAEEELLNMLPAMQKG DPTWPELRAMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAALFYLAMKKKAVVWGLY RSHKNVKMTAFFSNNFNEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETSSTYKKILQR------------HVLGQDHQ--------- ----------------------------------IPMHQDPFLRSMAHWVLDDYSRALDT LLEQ---------PKP-------------------------NVNASNQ------------ ------------------------------------------------------------ ------------------------EVFNFYTYLRTHPLLLRRHFGSSE---KAKVG---- ------LTAEGRMADSISLIERRLFFTAANAHLQAGCPMLALEVLSKMPKVVKKSKL--- -------------LLNQEKPSLSSTGS--------------------------------- ------------------------------------------------------------ -------------------------DNPAGEKGKDQ----------------------AS ALDWSQPTINGFESISD---TLSSPREDHSQSDSLLSFDWSQPSVTLQDEPLELKWDSDK ED---SE-DE--------------------------------------EAGLAMKNIKPE DTTVIHESADSASVSTDVTDSSLLL----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------S---------------- --------------E--------------------------------------------- --------DILVARLKFSSCLKVLTAELRTLSTGYELDGGKLRHQLCHWLERE------- ---------------------V-------------------------------------- VALQSCCGYNPYLQQL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AEGIS----------------------A DLSQVRVG----DEQETQGAAEEARVVQ-----------------------------RR- ---------RRLWLQRN----QPLLRIFLSYCSLHGSHGGGLASVRMELILLLQESQ--- ---------------------QV------------------------------------- ------------------------------------------RSISNTQTS--------- ------------------------------------------------------------ ------------------------------------------------------------ ----VPLLLACTASSKTVVANPIVHLTNLTHDILHTINSLDSPPNPDVINNEIYVMHTLA ASLSACIYQCL----CDGHNY-------------------------------------S- --HINQFTGTVYQ--------------SILLSHQHPVRTLSMDEAVLPNTSPAQWPG--- -----ISALVRLLS-AAGEENQPSLGVLLCEILTAVYLSLFVHGLATHSSNELFRIVAHP LNSKLWVAVFGGGARIP------------------------------------AVEKSS- ------------P----------------------------------PP----------- ------------------------------------------------------------ ERKQRRFRLRSSRSSSRE----------------------VPDGPASPG--P-SPIVE-- --------------------------------QE-ASIFKERFVPPELSIWDYFIAKPFL PPSTSRVEYDSEESQGSE-D--EEE----EDE-----D-KFADAFDTNSPLQEHSNSNSY SWCLMRLAMVQLVLVNLKSFYPMAGHDLMDLPVCSPLCHSVLKTLQRWEQVLLKRLEIFG GPPSKYISTQPMDETIASGPALLRHKALFEPSNTPFRSRHHSALPVKRLWQYLVKQEEVQ ETFIRNIFTKKRDQ---------------------NE-------------------IEAD LGYPGGKARIVHKESDIITAFAINKANRNCLVIASTHDIQELDVSSILATQILTWIDDEP ETEVK---GGDEFLVVQARDDFSTLHGTTPYTHSSPGTPINMPWLGSLQTGRGAA----M LIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNYQ GNKFGIVDADGALSLWQTNTSGNTQKPYL--TLQCHNKTAHDFVFVGSSSLIATAGISTD NRNVCLWDTLVPPTSSLVH--------------------GFSCHESGATVLALASKQQLL ISGGRKGWISVLDLTQKLQRQSFQAHDSPVKALAVDSTEGCFISGSSEGNIKVWSMSTQS LLHTFPNEHARQSLFRNLGTGVMQIETAPGNHIFSCGADGTMKMRVLPDCL--------- ---SA-----------------YSNNVKNDVKFIM >ENSEEEP00000015747 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LKFSPGGEFFATAG---------------QDDCLVKVWYSTSKWQWDS PKLFTPPE--LTSQGEVNFSFIYLTHPRSVTGFSWRKTSKFMP-R--------------- ---------------------------------------G--------------AVGNVL LTCCKDSVCRLWAETLLPSDCLLSGLRYS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PGSNN----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------TGNTLKSASVKKAQCNNKVRCTAQLAHTGPLPQQQNK -HYAHRAS------AP-HANALCHFHIAASINPATDIPLLPSISSLSGSDEEEPGGPFTV HWLNNKELHLTLTMEVFLQQLRGTLEQ--------------------------------- ------------HNP-----------------------------PHTAQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------YDEEGNVASPEGRKGEQSA-DAASGP--------------------------- ---------------------------------------------------------LPA AAVEHQVDVLLGDWNKAADMLYSIHPMDGSLLVWHVDWLDEYQPGMFRQVQVSFASRIPV AFPTGDANSLSRSVVMYACNRNVDLAIQHGRQ----RPT-ALPRSSSILV---------- -------------------------------------------GLGQGKACSNSLRLSIF TPNVLMISKHADGSLNQWAVSFAEGSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEVDSV----------------------------------QSL-------- -------------------------------PGPLPA----------SRRSRVSLGTVSQ DPNAIYSELILWRVDPVGPLSFSGGVSELARINSLHASAFSNVAWLPSLIPSSCL--GLY GDSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTARPGCIIELDAITD--------------------F------------ ------------------V----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SSTSTLFSARFFLVVMEFTQSGRSLLHMW----------------------- --------------------------------HLQLAAI--------------------- ------------------------------------------------------------ ------------------------------------------------PVAMVN------ ----------------------TQTSDNDTSSPANKDTAAL------------------- --------------SP-------------------------------------------- ------------------------------------------------------------ --------------------LSRSNLRSACRLMLTSERVFSQELNLPEGVEVIRVTPAAG HLSSSSLQPAGRAPYLLATSCSDGTMRFWTCSTACDD----YIP---DTL---------- ----------TYAWEEWPLLVEEGLPNSSAVSIPGRPVGISCCHTSRVAVAYR------G AKSLGLAAR--------------------------------------------------- ------------------------------------------------------------ -------------------------------EPL-----------------------LH- --------------------------VSIFQCESTGGSQWMLEQTLKLD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GSSSL---------------- -------TGNSSD--HLTLPSLQENLVVTG------------------------------ -------ECMGSSGKGLVHLDWVSREDGSHILTVGLGSKLYMYGTLSGKPPELGL-SDSS RECS----SSRLVLLRIVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APAK------------------------------------SGLTTCDTNVGSVN----- ---------------------SITGAVKQEGSNLQP------------------------ -------------------PKKTLMRSMTSLAQKLS---GKRTM-YDLPAEMEDYGLFEA AHHLFPTLPQYHPVQLLELMDLGKVRRAKAILSHLVKCIAGEIVALKDAT-D-------- ---NQERRLRSLSIS---ASGSTARDPKMFNK-AEN--ADYTEIDSVPPLPLYALLAAD- EEITPKA----KDKT-----------SSVSGD-----------------SGHGSS----- ------------------------------------------RTDTYDELFQATTLSMDD --------------------MDPL-DGEDEDASA-------------------------- --------------------------------------KVIDLSQYSPTFFGLEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTVASTSTDIGESQEKSQGGETLDECGLKFLLAVRLH TFLLTSLPLAHRAQLLCQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPTWPELRAMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAALFYLAMKKKAVVWGLY RSHKNTKMTAFFSNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KIQDLQLALVISRLYESEFETSSTYKKILQR------------YVLGEDRQ--------- ----------------------------------IPMHQDPFLRSMAYWVLEDYSRALDT LLEQ---------PK--------------------------------------------- ----------------LDA------SHQGST--------------------------TSP CNP---------------------AVFNFYTYLRTHPLLLRRHFVSSD---KAKVG---- ------LTAEGRMADSISLVERRLFFTAANAHLQAGCPMLALEVLSKMPKVVKRSKL--- -------------LRKQEKPSPSLTGSCS------------------------------- ---------------------------------------------------------PPS KS-------------------RKEQG---------------------------------S ALDWSQPDLNGFESVSD---TLSSSREDHSHSDSVLSFDWSQPSMTLQDEPLELKWDSDK ED---SE-DE--------------------------------------EAGLAMKNIQP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EIAAVSLSAPNSTSASLDAELDDPPILS------------------ -------VDILAARLKFISCLKILTAELRTLSTGYELDGGKLRSQLCHWLERE------- ---------------------V-------------------------------------- MALQRCCGYNPNLQQL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PGGIS----------------------A DLVQ-DVG----EEQRAEGTAEQARKVQ-----------------------------HW- ---------RRLWLQRN----QPLLRIFLSYCSLHGSHGGGLASVRMELILLLQQSQ--- ---------------------QT------------------------------------- ------------------------------------------PASSEKQAS--------- ------------------------------------------------------------ ------------------------------------------------------------ ----VPLLLACTASSKTVVANPIVHLTNLTHDILHTINTLDSPPHPDVINNEIYVMHTLA ASLSACIYQCL----CDGHDY-------------------------------------S- --HINQFTGTVYQ--------------SILLSHQHPLRTLSMDEAVLPNTSPAQWPG--- -----ISALMRLLS-NAGEENQPGLGMLLCEILTAVFLSLFVHGLATHSSLELFRIAAHS LNSKLWVAVFGGGAHLP------------------------------------VV----- ------------------------------------------------------------ ----------------------DKASSSSGWLEPSTL--------------------EEQ ERKQRRFKLRSSRSSSRE----------------------AQDSPA--S--R-GPVLE-- --------------------------------QD-VSVLKERFVPPELSIWDYFIAKPFL PLSASQGEYDSEESQGSE-E--EEE----EEEEDKEED-EIGESFDAISPLQEHSNNNSY SWCLMRLAMVQLVLVNLKSFYPIAGHDLLDLPVSSPLCHAVLKTLQRWEQVLLKRLEIFG GPPSNYISTHATDEAVSSGPALLRHKSLLEPTNTPFRSRHRSALPVKRLWQFLVKREEVQ DTFIRNIFTKKQDP---------------------NE-------------------VEAD LGYPGGKARIIHKESDIITAFAINKANRNCLAIASTHDIQELDVSSILATQILTWVDDEA ETEVK---GSDDFLVVHARDDYSTLHGTTPYTHSSPGTPINMPWLGSHQTGRGAA----M LIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNYQ GNKFGIVDADGALSLWQTNTSGTAPKPYL--TLQCHNKTAHDFVFVSSSSLIATAGLSTD NRNVCLWDTLVAPSSSLVH--------------------GFSCHESGATVLVLAPRQQLL ISGGRKGWISVLDLMQKLQRQCFQAHDSPVKALAVDATEDRFVSGSAEGNIKVWSMSTQC LLHTFPNEHARQSIFRNLGTGVMQVEMAPGNHVFSCGADGTMKMRVLPDCF--------- ---SA-----------------HGNNIKSDVRFIM >ENSSFOP00015033731 MNLHQVLTGAVNPGDNCFAVGNINEEPFTAYASGCDIVVLGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGNVVCVFEPVPLSDPKEKTPP----------------------KLNYQW QKSGQFILDSAALNLAWDPS---------------------------------------- ------------------------------------GTY-LLTGSTSLQLWSI------- ------------------------------------------DRA-------------SV NSEAKESLSFEIPR---------------------------------------------- -----------------SSWKC-----------VW------------------------- --QCKTASPVHLIKFSPGGDFFATAG---------------QDDCLVKVWYSTSRWQSGG ATLFTPPE--PFSHGEMDFSFIYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------SVCNVL LTCCKDSVCRLWAETLLPSDSVLS------------------------------------ ------------------------------------------------------------ -RPTRSYGNNAGVEAHRSAGITEKLSSNIQTQSRST------------------------ ---------------------------LE------------------------------- ------------------------------------------------------------ -----------LNLKDTWRGP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ERSLGQPAHTGFLPHQQDR -HQAHRAN------MTLHANALCHFHIAASINPATDIPLLPSISSLSTADDDELGGPFTV HWLNNKELHLTLAMEVFLHQLRSTVEQ--------------------------------- ------------QSQ-----------------------------EQASQSDE-------- ------------------------------------EF---------------------- -------------RSDEDELPISPTKEKKGKGQGALMG---------------------- ------------------------------------------------------------ -------------------------------IP--------------------------- ---------------------------------------------------------LPA AAVDHQMALLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQVQVSFVSRIPV AFPTGDANSLSRSVVMYACNKNVDLAIQQGRQQGRHRPT-RLPHSSSALI---------- -------------------------------------------SSGHSKNS--GLRLSIF TPNVLMISKHADGSLNQWAVSFAEESAFSTVLSVSHKSRYCGHRFHLNGLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEVD------------------------------------------HAQNG SFP-------------GCP-------------------------------NRSSLEAVSQ DPNAIYSELILWRVDPVGPLSFSGGVSELARINSLHASAFSNVAWLPILIPSHCL--GVY GNSPSACFIASDGLSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISLQSTARPGCIIALDAITD--------------------F------------ ------------------QGKKTQLLHVFEEDLILS------------------------ --------------------------------------NE-------------------- ----------------------------------------------T------------- -----------------------------------PDPSISTSGRIASG----------- ------QS-----GFSARFFLVVMECTQSGRSLLHMW----------------------- --------------------------------HLQLAAQQV--------I---------- --------V--------------------------------------------------- --DE---------------------------PP---------------------VSSNRD STNSSHFSFSPERLSTLKPVSST------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SNLQTACRLQLVSHRVYSQELELPEGVEVIQVTPSAG HLSSSSLQPSSRAPYLLATSCSDHKVRFWRCRV--------------ELGD--------- ---P------AYVWEEWPLLVQAGLDSGSALNVPGRPLHVSCCHTGRVAVAY-------- ---------R-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -RDPSTSLGLRDSST----------LVSIFQCESTGGSQWLLEQT--------------- ------------------------------------------------------------ LSLEDTTP---------------------------------------------------- ------------------------------------------------------------ ----------VH------------------------------------------------ -------PDKVTNRHGVPVLHSNQEMIMQTEVSPESNT---------------------- ------------------------------------------------------------ --------------RSLVHLDWVSREDGSHILTVGNGSKLQMYGLLSGKPPELGL-REGW REGSSQQNSSRLVLLRCVDLVSSVEGALPIPVSLSWVRNGILVVGMDCEMHVYSQWQPPA ------------------------------LAKP-------------------------- ------PSVAGDVDTGSVISLVAAVRQGPEEAQTAP------------------------ ------------------------------------------------------------ -----------------------------------P------------------------ -------------------PRRNLTRSMTSLAQKLS---GKRTA-YDLPPEMEDCGLFEA AHHLFPTLPQYHPVQLMELMDLGKVRRAKAILSHLVKCIAGEIVSLQDNS-T-------- ---SQERRLRSLSIS---ASGSTARDPKLFNN-TEN--PDYTEIDSIPPLPLYALLAAD- EDSSSKP----KDKAPVTSMGSTARGS--------------------------SE----- ------------------------------------------QTDTYNELFQ-------D NS--------------VVSELDPL-DSDQEDSGP-------------------------- --------------------------------------KVIDLSQYGPTFFGPEHTQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDIEESREKRKGGETLDECGLKFLLAVRLH TFLLTSLPPAHRARLLRQG-------------LSTCHFAWAFHSEAEEELLNMLPALQKG EPTWPELRAMGVGWWLRSTSKLRRCIEKVAKATFQRNNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTAFFSNDFNEDRWRRAALKNAFALLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMHDLQLALVISRLYESEFEASSTYKLILQR------------HVLGREAP--------- ----------------------------------TEIHQDPFLRSMAHWILEDYGLALDT LLVQ---------PSP-------------------------------------------- ------------------------------QSD----------------MIPGSIAILSP GHP---------------------EVFNFYTYLRTHPLLLRRHFQSSESKSSSRVG---- ------LSAEGRLADSISLVERRLFFTAAYAHFQAGCPMLALEVLSKMPKVVRKSKL--- -------------PLSQEDP---------------------------------------- ------------------------------------------------------------ ------VVSPGTRDSLLSADAR-----------QDR----------------------AS DLDWSHPVVNGYESVSD---GLS-----NSQSDSALSFDWSQPSLTMQDGPLELKWDS-- -E---SE-DE--------------------------------------ESGLAMKNI--- ------------------------------------------------HMETAIASKDMT DSSSPVETGSGFTDA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -DI-------------------------------------VAPS---------------- --------------E--------------------------------------------- --------DILTAQLKFMACLKILTTELRTLSTGYELDGGKLRYQLCHWLERE------- ---------------------V-------------------------------------- AALQSSCGYNADLQGVTEGIVGDSSC---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------DGPVEEMESGTGTAGGFA----------------------- EL-------------------------Q-----------------------------RR- ---------RRHWLRQSPPQPQPLLRMFLSYCSLHGSHGGGLASVQMELILLLQESQ--- ---------------------Q-------------------------------------- ---------------------------------------------------EDPPKS--- ---------------------AAFSLLQP------------------------------- ------------------------------------------------------------ -KSSIPLLLACTASAKTVVANPIVHLSNLTHDILHTINALDSPPHPSIINNKIYVMHTLA ASLSACIYQCL----CDGRSF-------------------------------------R- --QANHFTGTVYQ--------------SFLLSQQHPARTVSMDEAVLPNTSPAQWPG--- -----ILTLVRLLS-SAGEETQPGLTVLLCEVLTAVYLSLFVHGLATHSSNELFRIVAHP LNSKLWAAVFGGGARVP------------------------------------IADKRS- ------------P-------------------------FRL------PSG---------- ---------------------DD-------------L----------------------- DRKSKRFHLRSSRSTSAE----------------------SPQGP------P-SPVVE-- --------------------------------QE-TSIFKEEFVPPELSIWDYFIAKPFL PPSESRVEYDSEESQGSE-G--EEE----EED-----------IFDSNALLQEHSNPNSY SWCLMRLAMVQLVLVNLKSFYPMAGHDLLEVPVCSPLCHNVLKTLQRWEQLLQKRLEIFG GPPLKYISTHPLDETPAAGPALLRHKALFEPTNTPFRSIHHSALAVRRLWQYLVKQEEVQ ETFIRNIFTKKRDP---------------------NESGEEHSESNKNLEEPSFNQVETD LGYPGGKARIIHKESDIITAFAINKANRNCLVIASSHDIQELDVSSILATQILTWVDDEA --EAK---GSEDFLVIHAREDFGTLQGTTPYTHSSPGTPINMPWLGSMQTGRGAS----V LIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICYRSPGNSRVTRIRFNHQ GNKFGIVDADGVLSLWQTNMTGNTPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSSD NRNVCLWDTLVTPVNSLVH--------------------AFTCHESGATVLSLASRQQLL ISGGRKGWICVMDLRLRSPRQSFQAHDSPIKALAVDPTEDCFISGSAEGNIKIWSLTTQG LLHTFSSEHTRQSLFRNLGTGVMQIESGPANHIFSCGADGTMKMRILPDRY--------- ---GT-----------------GNSNPKNDIKFIM >ENSPKIP00000041123 MNLHQVLTGAVNPGDNCFAVGNVNDEPFTAYASGCDIIILGSNFERLQIIPGANHGNVQV GCVDSSLQGGL------------------------------------------------- ------------------------------------------------------------ ------VAASYGNVVCIFEPVSILDAKEKV-T----------------------KLSYQW QKRGQIVLKSAAINLAWDPT---------------------------------------- ------------------------------------GTQ-LLTGSASLQLWSN------- ------------------------------------------DR---------------- ------------PNLDP----------GEAEEPATFG----------------------- --------------SHLSSWRC-----------IWHKSYY-----------FGKFGKPEL GG----------------------------------------DDCLVKVWYNTSRWQSGG AALFTPPE--QASYGETDFSFVYLAHPRSVTGFSWRKTSKYMP-RLRASLCKTWFESCSL MKVISYILVNSSHFTAGSYRVPSGGHVSGTDGALTIQLK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LKESWRGP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ERCLGHPAYTGFLPHQQDR -HRIHWAK------GAINANALCHFHIAASINPATDIPLLPSISSLCVAGDEEPAGPFTV HWLNNKELHLTLAMEVYLQQLRASAEQRSPELSSRSDEGMGGGGASVSADSPTKTRPARD PGAWPGVPLAAVQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --VDHKLRLLLEDWNKAADMLFSIHPTDGSLLVWHVDWLDEYQPRMFRQAQVSFVSRIPV AFPTGDANSLSRSVVMYACNKNLDLAIQQGRQ----RPV-GLPRSASTLI---------- -------------------------------------------GSGQGKGA--GLRLSIF TPNVLMISKHADGSLNQWAVSFAEESAFSTVLSVSHKSRYCGHRFHLNGLACHPLLPLLL TTSHHNTPHSPSLDPTADLLLGPPSPAGASP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ DPNAIYSELILWRVDPVGPLSFSGGVSELARINSLHTSAFSNVAWLPVLIPSRCL--GAY GNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISR--------------------Y VGEVFSIISQQSTARPGCIISLDAITD--------------------FVRTRTNMLGGPF VIGDPSLSPFTYSPTGPS------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------FSARFFLVVMEYSQSGRTLLHMW----------------------- --------------------------------HLQLSALQV--------S---------- --------V--------------------------------------------------- --DV---------------------------PPDSSSCPPGSPERQSTPKNLMN------ ----------------------T------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SNLQSASRLQLSSRRVYSEELQLPDGVEVLQATPSAG HLSSSSLHPAGRAPYLLATSCSDHKVRFWRCQVV---------PEQAPSGD--------- ---Q------LYSWEEWPLLVETALDDGSAVSVPGRPIEISCCHTSRIAVAY-------- ---------R-------------------------------------------------- ------------------------------------------------------------ --------------------------------PMDTGVSH----------------RVQV G---------------------------IFQCESTGGSRWMLEQTFGLD----------- -------------------------------EAPSYKADGSLSMASLGTEEVSDDSSEPG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------T---------------------- ------------------------------------------------------------ --------------RTLVHLDWVSREDGSHILTVAIGPKLLMYGLLPGKPPELGL-SDGW RDG-----SSRLVLLRVVDLVSSVEGSPPVPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ -----------------------------------PQVGSAITGSVTSLLAALRQGGDDP TSP--------------------------------------------------------- ----------------------------------QP------------------------ -------------------PRRNLTRSMTSLAQKLS---GKRTA-YDLPADMEDCGLFEA AHHLFPTLPQYHPAQLMGLMDLGRVQRAKAILVHLVKCIAGEVVALRDGG-D-------- ---GHERRLRSLSIS---ASGSTARDPKIFSK-SEN--PDYTEIDSIPPLPLYALLAAD- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GGGPAKHDNVGDGP---------------- -----PGSAWPDTYNELFQAPAVEADPDILEGDREEAAKVIDLSRYGPTFFGLDHAQVLS GHLLYSRLPGLTRMEQMSLMALADTIATTSTDIGESQGKCQGGETLDECGLKFLLAVRLH TFLLTSLPPAHRAQLVRQG-------------LSTCHFAWAFHSEAEEELLNMLPALQKD DPTWHELRAMGVGWWLRSSSRLRRCMEKVAKAAFQRNNDPLDSAVFYLAMKKKAVVWGLY RSQQSVKMTAFFSNNFSEDRWRRAALKNAFSLLGKQRFLHSVAFFLLAGSLKDAVEVCLD KMQDLQLALVISRLYESEFEASSTYRKILQR------------HVLGHEAP--------- ----------------------------------AQIQQDPFLRSMAHWILEDYSQALDT LLVQPEGKAVSTIPS--------------------------------------------- ------------------------------------------------------------ --P---------------------EVFNFYTYLRMHPLLLRRHFRHPESRSSAQVG---- ------LATETRLADSITLLERRLFFSAAYAHLQAGCPMLALEVLSKMPKVIKKSR---- -------------------PAP-------------------------------------- ------------------------------------------------------------ -CQDMSAISPSTRDSLLSVEAK-----------QDR----------------------AS DLDWSQPVLNGYESASD---SLS-----NSRSDSAFSFDWSQPSGTMQEEPLELKWDT-- -E---SE-DD--------------------------------------ESGLAMKNVKAE S-----------------------VHAISKDNTESSSVTESEGDLVTT------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------S---------------- --------------E--------------------------------------------- --------DILTAQLKFTACLRILTTELRTLATGYELDGGRLRCQLCHWLERE------- ---------------------V-------------------------------------- AALQHSCSYNPDLEEV-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AGGIAGGPAQDESVQNPEGQLGMSLCSV EL-------------------------Q-----------------------------RR- ---------RRQWLRQN----EPLLRMFLSYSSLHGSHGGGLASVRMELILLLQESQ--- ---------------------Q-------------------------------------- ---------------------------------------------------DESVPS--- ---------------------AALVLAQP------------------------------- ------------------------------------------------------------ -KSSIPLLLACMASAKTVVANPIMHLTNLTHDILNTINSLDAPPHPSIVDSKIYVMHTLA ASLSACVYQCL----CDCRSL-------------------------------------RW ASHANQFTGIVYQ--------------SFLLSQQQPTRTMSTEEAVLPNTSPAQWPG--- -----MGALIRLLS-STGEETQSGLTVLLCEVLTAVYLSLFVHGLATHSSNELFRIVAHP LNGKLWAAVFGGGSRV-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------PVVERP SP---------SRMSSGEMALNESGTPASCISQE-ASIFKENFVPPELSIWDYFIAKPFL PPSENRVEYDSEESQGSE-D--ENE----DEDQ---------HLFDSDTALQEHSNANSY SWCLMRLAMVQLVLVNLKSFYPLAGHDLQDLPVGSPLCHNVLKTLQRWEQLLQKRLEVFG GPPPQYISTQPPDDSLTGGPAILRHKALLEPSNTPFRSSHHSALPVRRLWQYLVKQEAVQ ETFIRNIFTKKREQ---------------------NE-------------------IESD SGYPGGRPRIIHKESDIITAFAINKANRNCLVIASSHDIQELDVSSILATQILTWVDDET --ENK---GGEDFLVIHTREDF-TAHGTTPYTNSSPGTPINMPWLGSMQTGRGAS----V MIKRNINNVRRMTSHPNLPYYLTGAQDGSVRMFEWGHSQQIICYRSPGNSRVTRVRFNYQ GNKFGIVDADGGLSLWQTNMTGNAPKPYL--TLQCHNKTANDFVFVGSSSLIATAGLSTD NRNVCLWDTLVAPINSLVH--------------------AFSCHDTGATVLCLAPRQQLL ISGGRKGWISVLDLNLRTQRQTFQAHDSAVKALAVDPTETCFISGSSEGNIKVWGLADQG LLHVFPNEHARQSLFRNLGTGVMQLEVGPANHIFSCGADGTMKMRMLPDRF--------- ---GI-----------------SNGNPWGDVRFVL >ENSELUP00000039120 MNLHQVLTGAVNPGDNCFSVGGMNNHPFTAYASGCDIVILGSDFERLQIIPGAKHGNIQV GCVDSSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSVVCVFEPVQLTNQKNRT-------------------------LSYQW QKTGQFVLQSVVRNLAWDPT---------------------------------------- ------------------------------------GNA--------------------- ------------------------------------------------------------ -----------VPF---------------------------------------------- --------------------KCSRYILPISHVVVW----YIITVKHNASQNL-------- -----TASPIQLMKFSPDGEFFATAG---------------QDDCLVKIWYNTSKWHSSV TKLFTPPE--HASQGELNFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------SVCNVL LTCCKDSVCRLWAETLLPSDSLLSG----------------------------------- --------------------------H--------------------------------- -----------------------------------TLSHVNNGLNGDQLKSTGGSKRTPS RVKTSGQ------------------NPLE------------------------------- ------------------------------------------------------------ -----------LHLQESWRVP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LRGVAQPSLTGLLPCQQSR -HHNHKAN------AEPHANALCHFHIAASINPATDIPLLPSITSLCGGDEEEPGGPFTV HWLNNKELHLTLAMEVFLQQLRGSVEQSEPE----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------RSEEGKAEEPDYEED PEEVARRGP--------------------------------------------------- ---------------------------DPASVQ--------------------------- ---------------------------------------------------------LPA AVVEHQVEVLLEDWNRGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQVQVSFVSRIPV AFPTGDANSLSRSVVMYACNKNVDLAVQHGRQ----RPA-GLPHSSSVLVPYGPC----- ----------KA-----------SPA-----------------G---------SLRLSIF TPNVLMISTHADGSLNQWAVSFAEDSAFSAVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------SPDVD----------------------------------------------- AAPALASSSLGVGPGRGSP------------------------------------GVVSQ DPNAIYSELILWRVDPVGPLSFSGGVSELARINSLHSSAFSNIAWLPALIPSSCL--GVY CNSPSACFVASDGHSLRLYQAVIEAKKLLGELSNPERSK--------------------Y VGKVFNIISQQSTAKPGCIIELDDITE--------------------F------------ ------------------QGKEAQLLHVFEEDLILG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SGRTDQTCPYVRL SPADASQT-----GFSARFFLVVVEFTQTARSVLHMW----------------------- --------------------------------H--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------KTSVPSERENATSTPTNG----------------- ----S-------------------------FDFEAFS------------------APFVQ R-----------------NKACTSSLQSASRLTLTTQRLYSQELVLPKGVEVISVTPSAG HLSASSLQPAGGAPYLLATSCSDGKVRFWRCRV--------------SAAE--------- ---PDTRE-ATYTWEEWPLLVEEGLGNSSTLNVSGRPVEVSCCHTSRIAVAY-------- ---------R-------------------------------------------------- ------------------------------------------------------------ ---------------------------------------HNPNRLSPNPQPAARETQVH- --------------------------VGIFQCESTGGSQWVLEQTLVLD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ASSPLGDGDVAGGRDSPSVLS DNPNIHLPGN-------------------------------------------------- -------DCLRTSGRSLVHLDWVSREDGSHILTVGIGSKLYMYGLLSGRPAELGL-SEGS RGMV----SSRLVLLRSVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPPA KSVASSGAGVRHVGSASSLLAAVKPSHGDAF----------------------------- ------------------------------------------------------------ -SPA-------------------------------------------------------- -----------------------------------P------------------------ -------------------TKKTLTRSMTSLAQKLS---GKRTV-YDLPAEMEDYGLFEA AHHLFPTLPQYHPVQLLELMDLGKVRRAKAILSHLVKCIAGEIVALKDNA-T-------- ---NQEKRFRSRTIS---AGGSTTRDPKFLSK-GES--SDYTEIDSIPPLPLYALLAAD- EDCSPKP----KDKE-----------AKVSSD-----------------SGHGSS----- ------------------------------------------QTDAYDELFQGTGAGVDE --------------------LEPL-DQDQEESSG-------------------------- --------------------------------------KVIDLSRYSPTFFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDIGESHSKSKGGETLDECGLKFLLAVRLH MFLLTTLPQAHRGQLLHQGRKHNKESLWGHFRLSTGHYVWAFHSEAEEELLNMLPAMQKG DPTWPELRAMGVGWWLRSTNKLRRCIEKVAKASFQRQNDPMDAALFYLAMKKKAVVWGLY RSQNNAKMTAFFNNNFGEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCVE KMQDLQLALVISRLHESEFEMSSTYKRILQR------------HVLGQDRQ--------- ----------------------------------LPAHQDPFLRSMAHWVMEDYSRALDT LLVQ---------P---------------------------------------------- ------------------PTRDSQTT--------------------------------QP GNP---------------------EVFNFYTYLRTHPLLLRRHFGSSE---KAKVC---- ------LTAEGCMAHSISLVERRLFFTAAYAHLQAGCPMLALDVLSKMPKVLKRST---- -------------------P--------QADDPAS------------------------- -------------------PALSE-------------------------------RKY-- ----------------------------------EQ----------------------AS NLDWSRPMLNGSGSVSE---SLS-----NSQSDSVLSFDWSQPSLAVQDEALELKWDSDK ED---ED-DE--------------------------------------LQGLVMK----- ------------------------------------------------------------ --------------STTNNNNSS------------------------------------- ------------------------------------------------------------ -------------------------------------------------VFQEAQEAVSP L--------------------------------------AESPLDN-------------G DDA-------------------------------------LAPS---------------- --------------E--------------------------------------------- --------DILAAQLKFSACLKILTTELRTLSTGYELDGGKLRYQLCQWLERE------- ---------------------V-------------------------------------- VALQRCCSYKP--------------CMAGP------------------------------ ------------------------------------------------------------ ---------------------------------------------GVVEEEEEEGDRAQP ------------------GEA--------------------------------------- ---------------------------Q-----------------------------RT- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLLESQ--- ---------------------Q-------------------------------------- ------------------------------------------------------------ ----------------------------PTFSSAVA---PYLH----------------- ------------------------------------------------------------ -HASIPLLLACTASSKTVVANPMVHLTNLTHDILHTFNALDSPPHPDVVNNQIYVMHTLA ASLSACIYQCL----CNGHNY-------------------------------------S- --HVNQFTGIVYQ--------------SILLSHQNQGRTTSIEETV--NSHPAQWPG--- -----ISALVRLMD-SSGDEGQPGLAVLLCEILTAVFLGLFVHGLATHSSNELFRVVAHP LNSKLWVAVFGGGARTH------------------------------------VVEKPS- ------------P-------------------------VR-------------------- ---------S-------------------------------------------------- -----------------------------------------PEGPESPG--PTSPVVE-- --------------------------------QE-ASIFKEHFVPPELSIWDYFIAKPFL PPSLSRMEYDSEESQESE-D--EEDWDHYQD-------------FDPNSPGREHSNHNSY SWCLMRLAMVQLILGNLKSFYPMAGYDLIDLPVGSPLCHAVLKTLQRWEQVLLKRLEIFG GPPSKYISTPPVDETNPSGPAILRHKALFEPSNTPFRSSHHSVLPVKRLWQYLVKQEEVQ DTFIRNIFAKKRDP---------------------NE-------------------MEAD LGHPGGKARIIHKDSDIITAFAINKANRNCLVMASTHDIQELDVSSILATQIMTWIEDDA EAEVK----GDDFLVVQARDDFNSLHGTTPYTHSSPGTPINMPWLGGMQTGRGAA----M LIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNCRVTRIRFNHQ GNKFGIVDADGALSLWQTNTTGNTPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPMNSLVH--------------------AFSCHESGATVLSLAPKQQLL ITGGRKGWISVLELPHKQQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLSTQS LLHQFPNEHARQSLFRNLGTGVMQIEVGPANHIFSCGADGTMKMRILPERF--------- ---SV-----------------AKGCLRNDVKFII >ENSDCDP00000033610 MNLHQVLTGAVNPGDNCFSVGSLGNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNVQV GCVDCSQQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGNIVCIFEPVPVL-STEKSQS----------------------KFNYQW QKSGQFVLQSIVHNLAWHPT---------------------------------------- ------------------------------------GTQ-LLTGCTSLQLWSN------- ------------------------------------------QRYTWDPEQSGEDLNGD- ------------PQ---------------------------------------------- -----------------CPWKC-----------IW------------------------- --QCKTASPVHFIKFSPGGDFFATAG---------------QDDCLVKVWYSTNKWQWDA SKLFTPPQ---NSLGGLDFSFIYLAHPRSVTGFSWRKTSKYMP-G--------------- ---------------------------------------G--------------SVCNVL LTCCKDSVCRLWAETLLPSDYLLFGLKHNPTNIQHHSDPPRPRAAVGWMAGSSRAPSGSP LELNLRETRRDAPRHLFS--------H--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M-----------------GPPSN------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------QQSK -QHLHKPP------VP-HANALCHFHIAASINPATDIPLLPSISSLSTCDDEEPGGPFTV HWLNNKELQLTLAMEVFLQQLRST------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------QGRQNRAEPGNQGDDESSFLEDSCGGQAQADAEVDM--------- ------------------------------------------------------------ ------------------------------------------------------------ AAVEHHVEVLLEDWNRVADMIFSIHPMDGSLLVWNVDWLDEYQPGMFRQVQVSFVSRIPV AFPTGDANSLSRSVVMYACNKNVDLAIQHGRQQQQQRPSASLPRSSSSLI---------- -----------SSFASAKPSSSSS--------------------------CPGSLRLSIF TPSVLMISKHADGSLNQWTVSFAEESAFSTVLSVSHRSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------SPEV------------------------------------------------ ---------------------TDPSLHRAT------S----------SRRGRVSSGAMPQ DPNAIYSELILWRVDPVGPLSFSGGVSELARINSLHSSAFSNVAWLPSLVPSRCM--GLY GNSPSACFVASDGHSLRLYQAVIEAKKLLSELANPEISK--------------------Y VGEVFNIISQQSTARPGCIIELDVITD--------------------F------------ ------------------QGKETQLLHVFEEDLILG------------------------ --------------------------------------RQ-------------------- ----------------------------------------------KTE----------- ----GAMKDAEN-----------------------------------DGR---------- ------QA-----AFSARFFLVVVELTPSGRSLLHMW----------------------- --------------------------------HLDLAAVPI--------T---------- --------I--------------------------------------------------- --DVAFNEAEKERASPSPENSAQLNCDLFIAPP--------------GP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ R-----------------NKLSNSNLQSACRLSLTSHRVFSQELGLPSGVEVIRVTPAAG HLSSSSLQPAGRAPYLLATSCSDGKVRFWRCGPA---------PDPTLEGE--------- ---S------AYVWEEWPLLLEEDLASSSAVSVSGQPTRVSCCHNSRVAVAY-------- ---------R-------------------------------------------------- ------------------------------------------------------------ ---------------------------------------AFPGHLSGN----SRDTLVH- --------------------------VAIFQCESTGGSHWLLEQTLIFD----------- ----CANDDKSLSSEDSP------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------GSCLVHLDWVSREDGSHILTVGIGSKLYMYGPLSGKPPELGL-SQGG RD------TSRLVLLRTVDLVSSVEGSLPLPVSLSWVRDGILVVGMDCEMHVYSQWQPPA ---------------------------------PVRSAASTDTDGASLNSLNPAAAAAKH ESPPPSP--------------------------LAP------------------------ ------------------------------------------------------------ -----------------------------------P------------------------ -------------------PRKTLTRSMTSLAQKLS---GKRTA-YDLPPEMEDRGLFET ACSLFPTLPQYHPFQLLELMDLGKVRRAKAILSHLVKCIAGEVVALRDGT-S-------- -GGGAERRLRSRTIS---AGGSTPRDSKFFHK-AES--ADYAEIDSVPPLPLYALIAAD- DDDNSAPPAAGKDKV-----------ASVSGD-----------------SGHGSS----- --------------------------------------PRNDSSSAYDELFQ-------- -------------------------------------------PADLHLDHALDSLGADQ EDAERP--------------------------------KVIDLSQYKPTAFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTVASTRMDVGESQGKEQGGEMLDECGLKFLLAVRLH TFLLTSLPPAQRAQLLHQG-------------LSTCHYAWAFHSEAEEELLSMLPAMQKG EATWPELRAMGVGWWLRSTNRLRRCIEKVAKASFQRNSDPLDAALFYLAMKKKAVVWGLY RSHKNVKMTEFFSNNFGEDRWRRAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCVE KMQDLQLALVISRLYESEFETSSTFKRILQR------------HVLGHDPQ--------- ----------------------------------IDAHPDPFLRSIARWVLDDYSRALDT LLEQ---------PS--------------------------------------------- --------------------------------DRAHASGHAAQQGAAASF---------P CNP---------------------EVFNFYTYLRTHPLLMRRHFGSPE---KSRVG---- ------LTAEARKADSVTLVERRLFFTAAHAHLQAGCPMLALEVLSKMPKVIKRSK---- -------------------P---------------------------------------- -----------------------WAGLDAP----------------SPPLGPCAGR---- ---------------------------------KSQ----------------------AS DFDWPRPVLNGFGSAADVALSPN-----HSHSDSVLSFDWSQPSASLQDEPLELRWDSEK EN---SD-D--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ DDGAEEGSGLAMKALQHAEPAAASPCTSTEASSSFDPADEIPPS---------------- --------------E--------------------------------------------- --------DILAAQLKFSACLKILTTELRTLSTGYELDGGKLRYQLCHWLERE------- ---------------------V-------------------------------------- LALQKSCGYNPFL----------------PS----------------------------- ------------------------------------------------------------ --------------------AGGAGIGDLSRSASGAREEAAGGGGG-------------- --------------------------------------GP-------------------- ---------------------------Q-----------------------------RS- ---------RRLWLQRN----QPLLRIFLSYCSLHGSHGGGLASVRMELILLLQESQ--- ---------------------Q-------------------------------------- ---------------------------------------------------EE------- -------------------------------CSAVATLNPQL------------------ ------------------------------------------------------------ -HASVPLLLACTASSKTVVANPVVHLANLTHDILHTINGLDSPPHPDTAGHEIHVMHTLA ASLSACIYQCL----CDGHSY-------------------------------------S- --QVNQFTGIVYE--------------SVLLSPAHTSRYLILGDTLLPDTSPAQWPG--- -----ISALVRLLS-ACTEEGRPGLAVLLCEILTAVFLSLFAHGLATHSSQQLFRTVAHP LNSKLWVAVFGGGAQV-------------------------------------------- ------------------------------------------------------------ --------DSTQERPAAYSVQEDV------------------------------------ ERKQKLFRLRSSRSRSRD----------------------TPDSPLSPSGPP-SPAPE-- --------------------------------QN-PDSFTERFVPPELSIWDFFIAKPFL PPSESRVEYDSEESQGSE-E--EED----DDE-----E-EYAEALDSNPPIQEHSNHNSY SWCLMRLAMVQIVLGNLKSFYPMAGYDLMDLPVASPLCHTVLKTLQRWEQVLLKRLEIFG GPPPNYISTSPMDESMTSGPALLRHKALFEPSNTPFRSRRNAALPVKRLWHYLVKQEAVQ ETFIRNIFTKKRDP---------------------NE-------------------VETD LGSPVEKARIVHKDSDIITAFAINKANRNCLVIASTHDIQELDVSSILATQILTWIDED- DVDPK---GSDEFLVVQAREDFVSLHGSTPYTHSSPGTPINMPWLGSMQTGRGAA----V LIKRNITNVRRMASHPTLPYYLTGAQDGSVRMFEWGHAQQITCFRSPGNSRVTRIRFNYQ GNKFGVVDSDGSLSLWQTNSSGNTPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSID NRNVCLWDTLVTPSKSLVH--------------------AFTCHESEATVLSLAPKQQLL LAGGRKGWISVLDLAQRVQRQSLQAHDSPVKALAVGSTEACFISGSAEGNLKVWSLSTQT LLHSFPNEHSRQSLFRNLGTGVMQIEVGPSDHVFSCGADGTMKMRVLPDRH--------- ---SA-----------------AG---RNDVKFII >ENSACLP00000019542 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------VRP--------------------------------T------------KLNCQW QKTGQFVLQSIVRNLAWHPT---------------------------------------- ------------------------------------GCT-LLTGSSSLQLWSN------- --------V-DGVKDE-------------------------------------------- -------------------------------------------ADERGQPA--------- --------EMTIRDCR-SAWRC-----------IW------------------------- --QSKTASPVNLMKFSPDGEFFATAG---------------QDDCLIKVWYSTSKWKMGV TTLFTPPDTNVSDPEELAFSFIYLAHPRSVTSFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLSG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------KNPSSGQHSET---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LKSS---- --------------------------------LSWTSG---------------------- ------------------------------------------------------------ -----------------------------------------------------LPHLQSG -HCNHKKS---SNNMP-HANALCHFHIAASINPATDIPLLPSISSLNAVDDEEPGGPFSV HWLNNKELHFTLAMEVFLQQLRISVEQ--------------------------------- ------------QNECS------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------NEDDFEEEEN--RPSEPQGPGTVE ---------------------------------------------------------LPL AAVEHQLDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYHPGMFRQAQVSFASRIPV AFPAGDAISLSQSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQAK SALISYGGQGKS-----------AP--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSILVPPEASSS-GFSHSA----------------------------- ------------------------------------------SLSCGSRPTRVSLGMVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GLY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEHLILG------------------------ --------------------------------------TE-------------------- ----------------------------------------------ITESIHETPDSPRT --------------------AS---------SKP-------------------------- -------------AFSARFFLVVVELSPTGRSLLHMW----------------------- --------------------------------HLHLAARPV--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------AHKDLTTTSPLNSSQFVYDAPS------------------SPVTQ K-----------------SKSCTSNLQSACRLSLTTHRLYSQELALPAEVEAISVTPSAG HLSASCSLPAGHVPYLLATFCSDGKVRFWRCNVMTTE----------------------- ---PPTVDNLVYQWEEWPLLVEEKLPSSSAVSVPGRPIEVSCCHAGRFAVAY-------- ---------KQMPT---------------------------------------------- ------SASSPF------------------------------------------------ --------------------------------PL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----NTDPMSS------------------------------------------------- --YPLSSSTTASASIPSNM----------------------------------------- ---------------------------DLS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---IQNENCLGSTGKSLVHLDWVSQEDGSHILTVGIGTKIYIYGRLSGKPPDLGVSSDAN RDQS----LSRLVLLRSVSLFSSVEGSPPIPVSLSWVRDGILVVGMECEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APPKPTVTVAQDKDISSSVSSIVSAVRQCQEEGLSPGAPTSSLS--------------- -----------------------------------L------------------------ -------------------PKKTLTRSMTSLAQKLS---GKKTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIITLQDSS-T-------- ---SPEKRVRSRTIS---VGGSTATDQKMFSK-AENSSADYTEISSIPPLPLYALLGAD- DDT-PKP-------V-----------GSVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPNVMD --------------------LDPL-DSDQEKTGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIASTSIDLNDSQGKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLRQG-------------LSTCHYAWGFHSEAEEELLNMLPAMQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFHNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCIE KMQDLQLALVISRLYEFEFETASTYKKILQR------------HVLGQDKQV--FHE--- ------------------------FQ--------IPAHQDPFLRSMAYWVLEDYSKALDT LLEQ---------KAN-----IARSGSAENRYDTG------------------------- -------------TSSV-----------------------------------------SA CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSN---KAKVG---- ------LTAEVRSADSISLDERRLFFTAAYAHLHAGCPMLALEVLSKMPKVRKHSRP--Q DDTGNTA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-VSVGSRNGQAS DPDWCQSALNGYESDGN---SLS-----NSRSDSVLSFDWSQPSVVVPDEPLELKWDSDK DD---EE-ND-ED-EEETK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------NG--------KSG------------------SGS-----VFHEPVSLVEESEDS NDY-------------------------------------IEPS---------------- --------------D--------------------------------------------- --------DILVTQLKFAACLKIMTNELRTLSTGYELDGGKLRYQLCLWLERE------- ---------------------V-------------------------------------- GALQHCCSYKRCL----------------PELSVQGDVPVSGLVEEEQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------V GVDSW---LRRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ------------------------------------------------------------ ------------------------------------------------------------ ---QV--------I-----KMA--------------------TFL--------------- ------------------------------------------------------------ SPTSIPLLMACTTNVKTVVANPLVYLTNLTHDILQTISALDSPPHPDVVTNEIYVMHTLA ASLSACIYQCL----CDGHTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQPLKTISMDESVQPNTSPAQWPG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMTTHSCNELFRIMAHP LNSKLWVTVFGGGARIP------------------------------------VIEKLSS PTRTPP------P----------------------------------------------- ------------------------------------------------------------ -----------------------G--------DSFG--GCKREGPLSPK--HHVPVVE-- --------------------------------QEAPSIFKEQFVPPELSIWDYFIAKPSL PPSENRVDYDSEASQGSE-D--EDD----DDD-----D-EYDDVFDPNSPQREHSNHNSY SWCLMRLAMVQLVLANLKSFYLTAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTHLHDEIATPGPALLRHKTLFEASNTPFRSSHHSALPVKRLWHFLVKQEEVQ ETFIRNIFTKKPGTH---------------------Q-------------------TESD QGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAEAKG-VGGDDFLVVHTRDDFAALHGTTPYTHSNPGTPINVPWLGGMQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGALSLWQTNTSGTTPKPYL--TLQCHNKTANDFLFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVQ--------------------AFSCHESGATVLSMAPRQQLL ITGGRKGWISVLELSHKHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLTTHS LLYSFPNEHARQSLFRNLGTGVMQLEVGPANYIFSCGADGTMKMRILPNRF--------- ---SV--T-NNNH-----------GNLKNDVKFFI >ENSMZEP00005011679 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------VRP--------------------------------T------------KLNCQW QKTGQFVLQSIVRNLAWHPT---------------------------------------- ------------------------------------GCT-LLTGSSSLQLWSN------- --------V-DGVKDE-------------------------------------------- -------------------------------------------ADERGQPA--------- --------EMTIRDCR-SAWRC-----------IW------------------------- --QSKTASPVNLMKFSPDGEFFATAG---------------QDDCLIKVWYSTSKWKMGV TTLFTPPDANVSDPGELAFSFIYLAHPRSVTSFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLSG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------KNPSSGQHSET---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LKSS---- --------------------------------LSWTSG---------------------- ------------------------------------------------------------ -----------------------------------------------------LPHLQSG -HCNHKKS---SNNMP-HANALCHFHIAASINPATDIPLLPSISSLNAVDDEEPGGPFSV HWLNNKELHFTLAMEVFLQQLRISVEQ--------------------------------- ------------QNECS------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------NEDDFEEEEN--RPSEPQGPGTVE ---------------------------------------------------------LPL AAVEHQLDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYHPGMFRQAQVSFASRIPV AFPAGDAISLSQSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQAK SALISYGGQGKS-----------AP--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSILVPPEASSS-GFSHSA----------------------------- ------------------------------------------SLSRGSRPTRVSLGMVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GLY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEHLILG------------------------ --------------------------------------TE-------------------- ----------------------------------------------ITESIHETPDSPRT --------------------AS---------SKP-------------------------- -------------AFSARFFLVVVELSPTGRSLLHMW----------------------- --------------------------------HLHLAARPV--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------AHKDLTTTSPLNSSQFVYDAPS------------------SPVTQ K-----------------SKSCTSNLQSACRLSLTTHRLYSQELALPAEVEAISVTPSAG HLSASCSLPAGHVPYLLATFCSDGKVRFWRCNVMTTE----------------------- ---PPTVDNLVYQWEEWPLLVEEKLPSSSAVSVPGRPIEVSCCHAGRFAVAY-------- ---------KQMPT---------------------------------------------- ------SASSPF------------------------------------------------ --------------------------------PL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----NTDPMSS------------------------------------------------- --YPLSSSTTASASIPSNM----------------------------------------- ---------------------------DLS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---IQNENCLGSTGKSLVHLDWVSQEDGSHILTVGIGTKIYIYGRLSGKPPDLGVSSDAN RDQS----LSRLVLLRSVSLFSSVEGSPPIPVSLSWVRDGILVVGMECEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APPKPTVTVAQDKDISSSVSSIVSAVRQCQEEGLSPGAPTSSLS--------------- -----------------------------------L------------------------ -------------------PKKTLTRSMTSLAQKLS---GKKTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIITLQDSS-T-------- ---SPEKRVRSRTIS---VGGSTATDQKMFSK-AENSSADYTEISSIPPLPLYALLGAD- DDT-PKP-------V-----------GSVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPNVMD --------------------LDPL-DSDQEKTGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIASTSIDLNDSQGKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLRQG-------------LSTCHYAWGFHSEAEEELLNMLPAMQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFHNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCIE KMQDLQLALVISRLYEFEFETASTYKKILQR------------HVLGQDKQV--FHE--- ------------------------FQ--------IPAHQDPFLRSMAYWVLEDYSKALDT LLEQ---------KAN-----IARSGSAENRYDTG------------------------- -------------TSSV-----------------------------------------SA CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSN---KAKVG---- ------LTAEVRSADSISLDERRLFFTAAYAHLHAGCPMLALEVLSKMPKVRKHSRP--Q DDTGNTA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSRNGQAS DPDWCQSALNGYESDGN---SLS-----NSRSDSVLSFDWSQPSVVVPDEPLELKWDSDK DD---EE-N--EG-EEETK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------NG--------KSG------------------SGS-----VFHEPVSLVEESEDS NDY-------------------------------------IEPS---------------- --------------D--------------------------------------------- --------DILVTQLKFAACLKIMTNELRTLSTGYELDGGKLRYQLCLWLERE------- ---------------------V-------------------------------------- GALQHCCSYKRCL----------------PELSVQGDVPVSGLVEEEQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------V GVDSW---LRRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ------------------------------------------------------------ ------------------------------------------------------------ ---QV--------I-----KMA--------------------TFL--------------- ------------------------------------------------------------ SPTSIPLLMACTTNVKTVVANPLVYLTNLTHDILQTISALDSPPHPDVVTNEIYVMHTLA ASLSACIYQCL----CDGHTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQPLKAISMDESVQPNTSPAQWPG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMTTHSCNELFRIMAHP LNSKLWVTVFGGGARIP------------------------------------VIEKLSS PTRTPP------P----------------------------------------------- ------------------------------------------------------------ -----------------------G--------DSFG--GCKREGPLSPK--HHVPVVE-- --------------------------------QEAPSIFKEQFVPPELSIWDYFIAKPSL PPSENRVDYDSEASQGSE-D--EDD----DDD-----D-EYGDVFDPNSPQREHSNHNSY SWCLMRLAMVQLVLANLKSFYLTAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTHLHDEIATPGPALLRHKTLFEASNTPFRSSHHSALPVKRLWHFLVKQEEVQ ETFIRNIFTKKPGTH---------------------Q-------------------TESD QGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAEAKG-VGGDDFLVVHTRDDFAALHGTTPYTHSNPGTPINVPWLGGMQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGALSLWQTNTSGTTPKPYL--TLQCHNKTANDFLFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVQ--------------------AFSCHESGATVLSMAPRQQLL ITGGRKGWISVLELSHKHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLTTHS LLYTFPNEHARQSLFRNLGTGVMQLEVGPANYIFSCGADGTMKMRILPNRF--------- ---SV--T-NNNH-----------GNLKNDVKFFI >ENSHBUP00000001531 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGTKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------VRP--------------------------------T------------KLNCQW QKTGQFVLQSIVRNLAWHPT---------------------------------------- ------------------------------------GCT-LLTGSSSLQLWSN------- --------V-DGVKDE-------------------------------------------- -------------------------------------------ADERGQPA--------- --------EMTIRDCR-SAWRC-----------IW------------------------- --QSKTASPVNLMKFSPDGEFFATAG---------------QDDCLIKVWYSTSKWKMGV TTLFTPPDANVSDLGELAFSFIYLAHPRSVTSFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLSG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------KNPSSGQHSET---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LKSS---- --------------------------------LSWTSG---------------------- ------------------------------------------------------------ -----------------------------------------------------LPHLQSG -HCNHKKS---SNNMP-HANALCHFHIAASINPATDIPLLPSISSLNAVDDEEPGGPFSV HWLNNKELHFTLAMEVFLQQLRISVEQ--------------------------------- ------------QNECS------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------NEDDFEEEEN--RPSEPQGPGTVE ---------------------------------------------------------LPL AAVEHQLDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYHPGMFRQAQVSFASRIPV AFPAGDAISLSQSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQAK SALISYGGQGKS-----------AP--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWTVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSILVPPEASSS-GFSHSA----------------------------- ------------------------------------------SLSRGSRPTRVSLGMVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GLY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEHLILG------------------------ --------------------------------------TE-------------------- ----------------------------------------------ITESTHETPDSPRT --------------------AS---------SKP-------------------------- -------------AFSARFFLVVVELSPTGRSLLHMW----------------------- --------------------------------HLHLAARPV--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------AHKDLTTTSPLNSSQFVYDAPS------------------SPVTQ K-----------------SKSCTSNLQSACRLSLTTHRLYSQELALPAEVEAISVTPSAG HLSASCSLPAGHVPYLLATSCSDGKVRFWRCNVMTTE----------------------- ---PPTVDNLVYQWEEWPLLVEEKLPSSSAVSVPGRPIEVSCCHAGRFAVAY-------- ---------KQMPT---------------------------------------------- ------SASSPF------------------------------------------------ --------------------------------PL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----NTDPMSS------------------------------------------------- --YPLSSSTTASASIPSNM----------------------------------------- ---------------------------DLS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---IQNENCLGSTGKSLVHLDWVSQEDGSHILTVGIGTKIYIYGRLSGKPPDLGVSSDAN RDQS----LSRLVLLRSVSLFSSVEGSPPIPVSLSWVRDGILVVGMECEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APPKPTVTVAQDKDISSSVSSIISAVRQCQEEGLSPGAPTSSLS--------------- -----------------------------------L------------------------ -------------------PKKTLTRSMTSLAQKLS---GKKTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIITLQDSS-T-------- ---SPEKRVRSRTIS---VGGSTATDQKMFSK-AENSSADYTEISSIPPLPLYALLGAD- DDT-PKP-------V-----------GSVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPNVMD --------------------LDPL-DNDQEKTGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIASTSIDLNDSQGKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLRQG-------------LSTCHYAWGFHSEAEEELLNMLPAMQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFHNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCIE KMQDLQLALVISRLYEFEFETASTYKKILQR------------HVLGQDKQV--FHE--- ------------------------FQ--------IPAHQDPFLRSMAYWVLEDYSKALDT LLEQ---------KAN-----IARSGSAENRYDTG------------------------- -------------TSSV-----------------------------------------SA CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSN---KAKVG---- ------LTAEVRSADSISLDERRLFFTAAYAHLHAGCPMLALEVLSKMPKVRKHSRP--Q DDTGNTA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSRNGQAS DPDWSQSALNGYESDGN---SLS-----NSRSDSVLSFDWSQPSVVVPDEPLELKWDSDK DD---EE-ND-ED-EEETK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------NG--------KSG------------------SGS-----VFHEPVSLVEESEDS NDY-------------------------------------IEPS---------------- --------------D--------------------------------------------- --------DILVTQLKFAACLKIMTNELRTLSTGYELDGGKLRYQLCLWLERE------- ---------------------V-------------------------------------- GALQHCCSYKRCL----------------PELSVQGDVPVSGLVEEEQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------V GVDSW---LRRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ------------------------------------------------------------ ------------------------------------------------------------ ---QVQSSSPLFL----------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTTNVKTVVANPLVYLTNLTHDILQTISALDSPPHPDVVTNEIYVMHTLA ASLSACIYQCL----CDGHTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQPLKTISMDESVQPNTSPAQWPG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMATHSCHELFRIMAHP LNSKLWVTVFGGGARIP------------------------------------VIEKLSS PTRTPP------P----------------------------------------------- ------------------------------------------------------------ -----------------------G--------DSFG--GCKREGPLSPK--HHVPVVE-- --------------------------------QEAPSIFKEQFVPPELSIWDYFIAKPSL PPSENRVDYDSEASQGSE-D--EDD----DDD-----D-EYDDVFDPNSPQREHSNHNSY SWCLMRLAMVQLVLANLKSFYLTAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTHLHDEIATPGPALLRHKTLFEASNTPFRSSHHSALPVKRLWHFLVKQEEVQ ETFIRNIFTKKPGTH---------------------Q-------------------TESD QGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAEAKG-VGGDDFLVVHTRDDFAALHGTTPYTHSNPGTPINVPWLGGMQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGALSLWQTNTSGTTPKPYL--TLQCHNKTANDFLFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVQ--------------------AFSCHESGATVLSMAPRQQLL ITGGRKGWISVLELSHKHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLTTHS LLYTFPNEHARQSLFRNLGTGVMQLEVGPANYIFSCGADGTMKMRILPNRF--------- ---SV--T-NNNH-----------GNLKNDVKFFI >ENSPNYP00000023099 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPVQQPDQK----------DSSLT------------KLNCQW QKTGQFVLQSIVRNLAWHPT---------------------------------------- ------------------------------------GCT-LLTGSSSLQLWSN------- --------V-DGVKDE-------------------------------------------- -------------------------------------------ADERGQPA--------- --------EMTIRDCR-SAWRC-----------IW------------------------- --QSKTASPVNLMKFSPDGEFFATAG---------------QDDCLIKVWYSTSKWKMGV TTLFTPPDANVSDPGELAFSFIYLAHPRSVTSFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLSG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------KNPSSGQHSET---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LKSSAGLS KKNGCNGKTHGQASQE--LDFQESRHYRDIPQLSWTSG---------------------- ------------------------------------------------------------ -----------------------------------------------------LPHLQSG -HCNHKKS---SNNMP-HANALCHFHIAASINPATDIPLLPSISSLNAVDDEEPGGPFSV HWLNNKELHFTLAMEVFLQQLRISVEQ--------------------------------- ------------QNECSNE----------------------------------------- ------------------------------------E----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PENEDDFEEEEN--RPSEPQGPGTVE ---------------------------------------------------------LPL AAVEHQLDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYHPGMFRQAQVSFASRIPV AFPAGDAISLSQSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQAK SALISYGGQGKS-----------AP--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSILVPPEASSS-GFSHSA----------------------------- ------------------------------------------SLSRGSRPTRVSLGMVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GLY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEHLILG------------------------ --------------------------------------TE-------------------- ----------------------------------------------ITESIHETPDSPRT --------------------AS---------SKP-------------------------- -------------AFSARFFLVVVELSPTGRSLLHMW----------------------- --------------------------------HLHLAARPV--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EETAAHKDLTTTSPLNSSQFVYDAPS------------------SPVTQ K-----------------SKSCTSNLQSACRLSLTTHRLYSQELALPAEVEAISVTPSAG HLSASCSLPAGHVPYLLATSCSDGKVRFWRCNVMTTE----------------------- ---PPTVENLVYQWEEWPLLVEEKLPSSSAVSVPGRPIEVSCCHAGRFAVAY-------- ---------KQMPST------------------------PLNLSPHLNAHGPLTS----- ---PPASASSPFVNYSTT---NTHL--------TPTL----------NVPHSPKPIH--- ------SPN------------------ASTREPL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----NTDPMSS------------------------------------------------- --YPLSSSTTASASIPSNM----------------------------------------- ---------------------------DLS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---IQNENCLGSTGKSLVHLDWVSQEDGSHILTVGIGTKIYIYGRLSGKPPDLGVSSDAN RDQS----LSRLVLLRSVSLFSSVEGSPPIPVSLSWVRDGILVVGMECEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APPKPTVTVAQDKDISSSVSSIISAVRQCQEEGLSPGAPTSSLS--------------- -----------------------------------L------------------------ -------------------PKKTLTRSMTSLAQKLS---GKKTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIITLQDSS-T-------- ---SPEKRVRSRTIS---VGGSTATDQKMFSK-AENSSADYTEISSIPPLPLYALLGAD- DDT-PKP-----DKV-----------GSVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPNVMD --------------------LDPL-DSDQEKTGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIASTSIDLNDSQGKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLRQG-------------LSTCHYAWGFHSEAEEELLNMLPAMQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFHNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCIE KMQDLQLALVISRLYEFEFETASTYKKILQR------------HVLGQDK---------- -------------------------Q--------IPAHQDPFLRSMAYWVLEDYSKALDT LLER---------KAN-----IARSGSAENRYDTG------------------------- -------------TSSV-----------------------------------------SA CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSN---KAKVG---- ------LTAEVRSADSISLDERRLFFTAAYAHLHAGCPMLALEVLSKMPKVRKHSRP--Q DDTGNTA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSRNGQAS DPDWSQSALNGYESDGN---SLS-----NSRSDSVLSFDWSQPSVVVPDEPLELKWDSDK DD---EE-ND-ED-EEETK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------NG--------K--------------------SGS-----VFHEPVSLVEESEDS NDY-------------------------------------IEPS---------------- --------------D--------------------------------------------- --------DILVTQLKFAACLKIMTNELRTLSTGYELDGGKLRYQLCLWLERE------- ---------------------V-------------------------------------- GALQHCCSYKRCL----------------PELSVQGDVPVSGLVEEEQ------------ ------------------------------------------------------------ ------------PGS--------------------------------------------- ----------------PRGDS--------------------------------------- ---------------------------H-----------------------------RS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDFIQSVVT VTSQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTTNVKTVVANPLVYLTNLTHDILQTISALDSPPHPDVVTNEIYVMHTLA ASLSACIYQCL----CDGQTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQPLKAISMDESVQPNTSPAQWPG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMATHSCNELFRIMAHP LNSKLWVTVFGGGARIP------------------------------------VIEKLSS PTRTPP------P--------------------------------ASPSGT--------- ------------------------------------------------------------ DRKSKRFRLLSSRSVSKEESGIE------------------REGPLSPK--HHVPVVE-- --------------------------------QEAPSIFKEQFVPPELSIWDYFIAKPSL PPSENRVDYDSEASQGSE-D--EDD----DDD-----D-EYDDVFDPNSPQREHSNHNSY SWCLMRLAMVQLVLANLKSFYLTAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTHLHDEIATPGPALLRHKTLFEASNTPFRSSHHSALPVKRLWHFLVKQEEVQ ETFIRNIFTKKPGTHQSVEDQTDNMKCSGMDETGNNQ-------------------TESD QGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAEAKG-VGGDDFLVVHTRDDFAAIHGTTPYTHSNPGTPINVPWLGGMQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGALSLWQTNTSGTTPKPYL--TLQCHNKTANDFLFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVQ--------------------AFSCHESGATVLSMAPRQQLL ITGGRKGWISVLELSHKHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLTTHS LLYTFPNEHARQSLFRNLGTGVMQLEVGPANYIFSCGADGTMKMRILPNRF--------- ---SV--T-NNNH-----------GNLKNDVKFFI >ENSNBRP00000021425 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVNCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------VRP--------------------------------T------------KLNCQW QKTGQFVLQSIVRNLAWHPTV--------------------------------------- -LNIILFCIS-------------------------R------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----TASPVNLMKFSPDGEFFATAG---------------QDDCLIKVWYSTSKWKMGV TTLFTPPDVNMSDPGELAFSFIYLAHPRSVTSFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLSG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------KNNSSGQHSET---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LKSS---- --------------------------------LSWTGG---------------------- ------------------------------------------------------------ -----------------------------------------------------LPHLQSG -HCNHKKS---SNNMP-HANALCHFHIAASINPATDIPLLPSISSLNAVDDEEPGGPFSV HWLNNKELHFTLAMEVFLQQLRISVEQ--------------------------------- ------------QNECSN------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EEEN--RLSEPQGPGTVE ---------------------------------------------------------LPL AAVEHQLDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYHPGMFRQAQVSFASRIPV AFPAGDAISLSQSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQAK SALISYGGQGKS-----------AP--------------------------SSSLRLSIF TPNVLMISTHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSILVPPEASSS-GFSHSA----------------------------- ------------------------------------------SLSRGSRPTRVSLGMVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GLY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEHLILG------------------------ --------------------------------------TE-------------------- ----------------------------------------------ITESIHETPDSPRM --------------------AS---------SKP-------------------------- -------------AFSARFFLVVVELSPTGRSLLHMW----------------------- --------------------------------HLHLAARPV--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------AHKDLTTTSPLNGSQFVYDASS------------------SPVTQ K-----------------SKSCTSNLQSACRLSLTTHRLYSQELALPAEVEAISVTPSAG HLSASCSLPAGHVPYLLATSCSDGKVRFWRCNVMTTE----------------------- ---PPTVDNLVYQWEEWPLLVEEKLPSSSAVSVPGRPIEVSCCHAGRFAVAY-------- ---------KQIP----------------------------------------------- ------------------------------------------------------------ --------N------------------ASTREPL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----NTDPMSS------------------------------------------------- --YPLSSSTTASASIPSNM----------------------------------------- ---------------------------DLS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---IRNENCLGSTGKSLVHLDWVSQEDGSHILTVGIGTKIYIYGRLSGKPPDLGVSSDAN RDQS----LSRLVLLRSVSLFSSVEGSPPIPVSLSWVRDGILVVGMECEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APPKPTVTVAQDKDISSSVSSIISAVRQCQEEGLSPGAPTSSLT--------------- -----------------------------------L------------------------ -------------------PKKTLTRSMTSLAQKLS---GKKTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVTLQDSS-T-------- ---SPEKRVRSRTIS---VGGSTATDQKMFSK-AENSSADYTEISSIPPLPLYALLGAD- DDT-PKP-----DKV-----------GSVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPNVMD --------------------LDPL-DNDQEKTGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIASTSIDLNDSQGKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLRQG-------------LSTCHYAWGFHSEAEEELLNMLPAMQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQRNSDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFHNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCIE KMQDLQLALVISRLYEFEFETASTYKKILQR------------HVLGQDKQV--FHE--- ------------------------FQ--------IPAHQDPFLRSMAYWVLEDYS----- ------------------------------------------------------------ -------------TSSV-----------------------------------------SA CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSN---KAKVG---- ------LTAEVRRAESISLDERRLFFTAAYAHLHAGCPMLALEVLSKMPKVRKHSRP--Q DDTGNTA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSRNGQAS DPDWSQSALNGYESEGN---SLS-----NSRSDSVLSFDWSQPSVVVPDEPLELKWDSDK DD---EE-ND-EDEEEETK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------NG--------KSG------------------SGS-----VFHEPVSLVEESEDS NDY-------------------------------------IEPS---------------- --------------D--------------------------------------------- --------DILVTQLKFAACLKIMTNELRTLSTGYELDGGKLRYQLCLWLERE------- ---------------------V-------------------------------------- GALQHCCSYKRCL----------------PELSVQGDVPVSGLVEEEQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------V GVDSW---LRRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ------------------------------------------------------------ ------------------------------------------------------------ ---QVQSSSPLFL----------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTTNVKTVVANPLVYLTNLTHDILQTISALDSPPHPDVVTNEIYVMHTLA ASLSACIYQCL----CDGHTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQPLKTISMDESVQPNTSPAQWPG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMATHSCNELFRIMAHP LNSKLWVTVFGGGARIP------------------------------------VIEKLTS P-----------------------------------------------SGT--------- ------------------------------------------------------------ DRKSKRFRLLSSRSGSKEESGIE------------------REGPLSPK--HHVPVVE-- --------------------------------QEAPSIFKEQFVPPELSIWDYFIAKPSL PPSENRVDYDSEASQGSE-D--E-D----DDD-----D-EYDDVFDPNSPQREHSNHNSY SWCLMRLAMVQLVLANLKSFYLTAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTHLHDEIATPGPALLRHKALFEASNTPFRSSHHSALPVKRLWHFLVKQEEVQ ETFIRNIFTKKPGTH---------------------Q-------------------TESD LGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAEAKG-VGGDDFLVVHTRDDFAALHGTTPYTHSNPGTPINVPWLGGVQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGALSLWQTNTSGTTPKPYL--TLQCHNKTANDFLFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVQ--------------------AFSCHESGATVLSMAPRQQLL ITGGRKGWISVLELSHKHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLNTHS LLYTFPNEHARQSLFRNLGTGVMQLEVGPANYIFSCGADGTMKMRILPNRF--------- ---SV--T-NNNH-----------GNLKNDVKFFI >ENSONIP00000018231 MNLHQVLTGAVNPGDNCFSVGRVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPVQQPDQK----------DGSLT------------KLNCQW QKTGQFVLQSMVRNLAWHPT---------------------------------------- ------------------------------------GST-LLTGSSSLQLWSN------- --------V-DGVKDE-------------------------------------------- -------------------------------------------ADERGQPA--------- --------EMTIRDCR-SAWRC-----------IW------------------------- --QSKTASPVNLMKFSPDGEFFATAG---------------QDDCLIKVWYSTSKWKMGV TTLFTPPEASMSDQGELAFSFIYLAHPRSVTSFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDGLLSG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------KNLSSGQHSET---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LKSSAGLS KKNACNGKTHGQASQEVNLDFQESRHYRDIPQLSWTSG---------------------- ------------------------------------------------------------ -----------------------------------------------------LPHLQSG -HCNHKKS---SNNMP-HANALCHFHIAASINPATDIPLLPSISSLNPVDDEEPGGPFSV HWLNNKELHFTLAMEVFLQQLRSSVEQ--------------------------------- ------------QNECSNEGYHD----------------------LY---------SFP- ------------------------------------E----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PENEDDFEEEEN--RPSEPQGPGTVE ---------------------------------------------------------LPL AAVEHQVDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYHPGMFRQAQVSFASRIPV AFPAGDAISLSQSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQAK SALISYGGQGKS-----------AP--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSILVPPEVSSS-GFSHSA----------------------------- ------------------------------------------SLSRGSRPKRVSLGMVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GLY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEHLILG------------------------ --------------------------------------TE-------------------- ----------------------------------------------ITESTHETPDSLRT --------------------AS---------SKP-------------------------- -------------AFSARFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAARPV--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------VETTAHKDLTTTSPLNGSQFVYDAPS------------------SPITQ K-----------------STSCTSNLQSACRLSLTTHRLYSQELALPAGVEAISVTPSAG HLSASCSLPAGHVPYLLATSCSDGKVRFWRCNVMTTE----------------------- ---PPTVDNLVYQWEEWPLLVKEKLPSSSAVSVQGQPIEVSCCHAGRFAVAY-------- ------------------------------------------------------------ ---------------------------------------------------NPKPIH--- ------SPN------------------ASTREPL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----NTDPMSS------------------------------------------------- --YPLSSSTTASASIPSNM----------------------------------------- ---------------------------DLS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---IRNENCLGSTGKSLVHLDWVSQEDGSHILTVGIGTKIYMYGRLSGKPPDLGVSSDAN RDQS----LSRLVLLRSVSLFSSVEGSPPIPVSLSWVRDGILVVGMECEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APPKPTVTVAQDKDISSSVSSIISAVRQCQEEGLSPGAPTSLLT--------------- -----------------------------------L------------------------ -------------------PKKTLTRSMTSLAQKLS---GKKTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVTLQDSS-T-------- ---SPEKRVRSRTIS---VGGSTATDQKMFSK-AENSSADYTEISSIPPLPLYALLGAD- DDT-PKP-----------------------------------------------ALKCC- -----TVS------------------QRNVL----YRQRQLHHTDAYDELFH--TPNVMD --------------------LDPL-DNDREKTGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIASTSIDLNDSQGKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLRQG-------------LSTCHYAWGFHSEAEEELLNMLPAMQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFHNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCIE KMQDLQLALVISRLYESEFETASTYKKILQR------------HVLGQDKQVCRLHE--- ------------------------FQ--------IPAHQDPFLRSMAYWVLEDYSRALDT LLEQ---------K--------------------GME----------------------- -----------KCTSSV-----------------------------------------SV CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSN---KAKVGVSSA NLSSQT----------ISLDERRLFFTAAYAHLHAGCPMLALEVLSQMPKVRKHSRP--Q DDTGNSA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSRNGQAS DPDWSQSALNGYESDGN---SLS-----NSRSDSVLSFDWSQPSVVVPDEPLELKWDSDK DD---ED-ND-EDEEEETK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------NA--------KSG------------------SGS-----VFHEPVSLGEESEDS NDY-------------------------------------IEPS---------------- --------------D--------------------------------------------- --------DILVTQLKFAACLKIMTNELRTLSTGYELDGGKLRYQLCLWLERE------- ---------------------V-------------------------------------- VALQHCCSYKPCL----------------PELSVQGDVPVSGLVEEEQ------------ ------------------------------------------------------------ ------------PGS--------------------------------------------- ----------------PRGDS--------------------------------------- ---------------------------H-----------------------------RS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDFIQSVVT VTSQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTTNVKTVVANPLVYLTNLTHDILQTISALDSPPHPDVVTNEIYVMHTLA ASLSACIYQCL----CDGHTYSF---------------------------------SHS- --HVNHFTGTVYQ--------------SVLLSQKQPLKTISMDESVQPNTSPAQWPG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMATHSCNELFRIMAHP LNSKLWVTVFGGGARIP------------------------------------VIEKPSS PARTPP------P--------------------------------ASPSGT--------- ------------------------------------------------------------ DRKSKRFRLLSSRSGSKEESGIE------------------REGPLSPK--HHVPVVE-- --------------------------------QEAPSIFKEQFVPPELSIWDYFIAKPSL PPSENRIDYDSEASQGSE-D--E-D----DDD-----D-EYDDVFDPNSPQREHSNHNSY SWCLMRLAMVQLVLANLKSFYLTAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTHLHDEIATPGPALLRHKALFEASNTPFRSSHHSALPVKRLWHFLVKQEEVQ ETFIRNIFTKKPGTHQSVEDQTDNMKCSGMDETGNNQ-------------------TESD LGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- ENEAKG-VGGDDFLVVHTRDDFVALHGTTPYTHSNPGTPINVPWLGGMQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGALSLWQTNTSGTTPKPYL--TLQCHNKTANDFLFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVQ--------------------AFSCHESGATVLSMAPRQQLL ITGGRKGWISVLELSHQHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLTTHG LLYTFPNEHARQSLFRNLGTGVMQLEVGPANHIFSCGADGTMKMRILPNRF--------- ---SV--T-NNNH-----------GNLKNDVKFFI >ENSACIP00000006619 MNLHQVLTGAVNPGDNCFSVGSINNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------V----------------------------------K------------KWNCQW QKTGQFVLQSMVRNLAWHPT---------------------------------------- ------------------------------------GST-LLTGSSSLQLWSN------- --------V-DRVKDE-------------------------------------------- -------------------------------------------AEERGQQA--------- --------EMTIRDSR-SAWRC-----------IW------------------------- --QSKTASPVNLMKFSPDGEFFATAG---------------QDDCLVKVWYSTSKWKLGV STLFTPPEVSMSDQGELAFSFIYLAHPRSVTGFTWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLSG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------KNHSCGQHSET---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LKSAAGLS RKNGCNGKTHGQTSQE----------------LSWTSA---------------------- ------------------------------------------------------------ -----------------------------------------------------LPHLQSG -HYNHKKS---S--MP-HANALCHFHIAASINPATDIPLLPSISSLNSVDDEEPGGLFTV HWLNNKELHFTLAMEVFLQQLRSSLEQ--------------------------------- ------------QSECS------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------NEDDFEEEEY--RQSEPQGPGTMQ ---------------------------------------------------------LPV AAVEHQVDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYHPGMFRQAQVSFASRIPV AFPAGDAISLSQSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQAK SALISYGGQGKA-----------TS--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSILVPPEAASS-GFSHAT----------------------------- ------------------------------------------SLSRGSRPNRVSLSVVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GLY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITDFVSMHEVQENWIFFSSGTKFF------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------S---------SKP-------------------------- -------------AFSARFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAAQP-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------DPTTTSPLNSSQFVYDTHS------------------SSVTQ K-----------------SKSCTSNLQSACRLSLTKHRLYSQELALPTGVEAISVAPSAG HLSASCSLPAGRVPYLLATSCSDGKVRFWRCNVVTTE----------------------- ---PPMMDNWVYQWEEWPLLVEERLPSSSAVSVPGHPIEVSCCHTGR------------- ------------------------------------------LSPHLNSHGPLNS----- ---PPAFASSPFVHYSTT---N-------------------------------------- ------------------------------------------------------------ -------------------------------CESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----NTDSTSS------------------------------------------------- --CALSSSTAGSASIPSNM----------------------------------------- ---------------------------DSS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---VRNEKCLASTGKSLVHLDWVSQEDGSHVLTVGIGTKIYMYGRLSGKPPDLGLSSDAN RDQS----LSRLVLLRSVSLFSSVEGSPPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APPKPIITIAQDRDISSSVSSIISAVRQCQEEGLSPGAPTSSLT--------------- -----------------------------------L------------------------ -------------------PKKALTRSMTSLAQKLS---GKKTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVKLQDSS-T-------- ---SHEKRVRSRTIS---AGGSTARDQKMFSK-AENSPPDYTEISSIPPLPLYALLAAD- EDT-PKP-------V-----------GSVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPNTGD --------------------LDPL-DNDQEEMGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRIEQMSLMALADTIASTSIDLNDSQ----GGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLRQG-------------LSTCHYAWGFHSEAEEELLNMLPAMQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDSAIFYLALKKKAVVWGLY RSQKNVKMTEFFHNNFSEDRWRKAALKNAFSLLGKQRFQHCAAFFLLAGSLKDAVEVCIE KMQDLQLALVISRLYESEFETSSTYKKILRR------------HVLGQDKQV-------- ------------------------------------SHHDPFLRSMAHWVLEDYSKALDT LLEQ---------TAN------------------S------------------------- -------------TSSV-----------------------------------------SP CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSD---KARVG---- ------LTAEGRRADSISLDERRLFFTAAYAHLHSGCPMLALEVLSKMPKVHKHSKL--Q EDTGNTG----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSAGSKNRQAS DPDWSQPALNGYESEGN---SLS-----NSRSDSVLSFDWSQPSLAVPDEPLELKWDSDK DD---EE-NN-EDEEE-TKESKSGRTADSCS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDA------ ---VST-----------------------------------------------GEESEDS NSF-------------------------------------IEPS---------------- --------------D--------------------------------------------- --------DILVAQLKFAACLKIMTNELRTLSTGYELDGGKLRYQLCLWLERE------- ---------------------V-------------------------------------- VALQHCCSYKPCL----------------PELSVQADVPVSGLVEEEQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------V GVDRW---LRRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ------------------------------------------------------------ ------------------------------------------------------------ ---QAQSSSPLVL----------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTTNVKTVVANPLVYLTNLTHDILHTISALDSPPHPDVVTNEIYVMHTLA ASLSASIYQCL----CDGHTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQPLKTVSMDESVQPNTSPTQWPG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMATHSCNELFRIVAHP LNSKLWVTVFGGGARIP------------------------------------VLEKPSS PTRTPP------P----------------------------------------------- ------------------------------------------------------------ ------------------ESGME------------------REGPLSPK--HHVPVME-- --------------------------------QEAPSIFKEQFVPPELSIWDYFIAKPSL PPSENRIDYDSEESQGSQ-D--E-D----EDD-----D-EYEDVFDPNSPQREHSNHNSY SWCLMRLAMVQLVLANLKAFYPMAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTHLHEETATPGPALLRHKALFEPSNTPF--SHHSALPVKRLWHFLVKQEEVQ ETFIRNIFTKKLGTHQ------------------------------------------SD LSCPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAEAKG-VGGDDFLVVHTRDDFAALHGTTPYTHSNPGTPINVPWLGGMQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGSTPKPYL--TLQCHNKTANDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHESGATVLSMAPRQQLL ITGGRKGWISVLELSHKHQRQSFQAHDSPVKALAIDPTEDCFISGSAEGNIKVWSLSTHC LLYTFPNEHARQSLFRNLGTGVMQIEVGPANHIFSCGADGTMKLRILPNRF--------- ---SV--T-NNNH-----------GNLKNDVKFFI >ENSCGOP00000002356 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPVQHPDQK----------DTSLT------------KLNCQW QKTGQFVLKSMVRNLAWHPT---------------------------------------- ------------------------------------GST-LLTGSSSLQLWSN------- --------A-DGVNDE-------------------------------------------- -------------------------------------------AEEVGTQK--------- --------EMTIRDHH-SAWKC-----------IW------------------------- --ESKTASPVSLMKFSPDGEFFATAG---------------QDDCLVKVWYGTSKWKLGV SRLFTPPEPSVSFQGALAFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLSGDSLLAG----------------------------------- -------------------------YH--------------------------------- ------------------------------------------------------------ ---------------------------------------NNHASGHHNDTPRCAGPTWK- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------NTCNGKSHGK TSQESNFQESLHASFHRDIP---------------------------------------- ----------------------------------------------QPSLTGCLPHHQSQ -HYNHKRS---SSSMP-HANALCHFHIAASINPATDIPLLPSISSLSAVDDEEPGGLFTV HWLNNKELHFTLAMEVFLQQLRGSLEQ--------------------------------- ------------QNECSHE----------------------------------------- ------------------------------------E----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PEDEDNFEEDDNGSRPSDSQGPEAVE ---------------------------------------------------------LPL EAVKHQVNVLLEEWNKGADMLFSIHPMDGSLLVWHIDWLDEYQPGMFRQAQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQTK SALISYGGQGKT-----------AP--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPDADSILAPPDAYSS-GFSHPA----------------------------- ------------------------------------------SLPRGSRPSRSSLGVVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTFIPSSCL--GVY CNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPDISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEDLILG------------------------ --------------------------------------SE-------------------- ----------------------------------------------RTESTQQTPDSPHS --------------------AS---------SKT-------------------------- -------------AFSARFFLVVVELTLTGRSILHMW----------------------- --------------------------------HLQLTARPI--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EETRTEKDATSASPSNSSTFSFDTFV------------------SPVTQ K-----------------SKPCTSNLQSACRLSLTTHMLYSQEMALPEGVEAISVTPSAG HLSASCSLPADRVPYLLATSCSDGKVRFWRCNVIATE----------------------- ---PSSLDNLMYQWEEWPLLVEERLPNSSAVSVQGHPIEVSCCHSGRIAVAY-------- ---------RQIPNT------------------------PLSLTPYLNIHGLLTS----- ---PPTLASSPYV----LNNNNTHL--------TPTVTVQCSP----------------- -------------------NLTPSPNQANTKEPL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----STDPT--------------------------------------------------- ------------------------------------------------------------ -----------------TGNANILGNMDMP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---IPNEDCPGSTSKSLVHLDWVSQEDGSHVLTVGIGTKIYMYGRLAGKPPELGLSSDAS RDQS----LSRLVLLRSVNLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APFKPNVPIAQDTDLSSSVSSIISAIRQSQEEGLSSGAPMSSLA--------------- -----------------------------------P------------------------ -------------------PKRALTRSMMSLAQKLS---GKRTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVALKDST-T-------- ---NPEKRVRSRTIS---AGGSTARDRKMFSK-AENSTADYTEISSIPPLPLYALLAADG EDTSPKP-----DKV-----------GSVSGD-----------------SGHGSS----- ------------------------------------------HADVYDELFH--TPSIVD --------------------LDPL-DDDQEETGN-------------------------- --------------------------------------KVIDLAQYSPTFFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDSQGNSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKTTLQKNNDPLDAAIFYLALKKKAVVWGLY RSQRNAKMTEFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCIE KMQDLQLALVISRLYESEFETASTYKKILQR------------HVLGQDKQ--------- ----------------------------------IPAHQDPFLRSMAHWVLEDYSRALDT LLDQ---------PAN-----STSSGSSARRCDIG------------------------- -------------SSSV-----------------------------------------ST CNP---------------------EVFNFYTYLRTHPLLLRRHFASSD---KAKVG---- ------LTAEGRRADSISLEERRLFFTAAYAHLQAGCPMLALEVLSKMPKVRKHSKLPNQ EDACIAA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSKKGQTS DHDWSQPALNGYESDRN---SLS-----NSQSDSVLSFDWSQPSLTHPDEPLGLKWDSDK DD---DD-DD-GDEEE-TKNGTNSITEDGSS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDTQDAMTA LTETVT-----------------------------------------------REESEDC NDF-------------------------------------LAPS---------------- --------------N--------------------------------------------- --------DILAAHLKFTACLKIMTNELRTLSTGYELDGGKLRCQLYQWLERE------- ---------------------V-------------------------------------- VALQRCCSYKPCL----------------PELSIQGEAPVSGLMEEEQ------------ ------------------------------------------------------------ ------------PGS--------------------------------------------- ----------------PRGDS--------------------------------------- ---------------------------Q-----------------------------RS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSIQSAVM PCCQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTANVKTVVANPIVYLTNLAHDILQTINSLDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDGHTH-------------------------------------S- --HVNHFTGIVYQ--------------SVLLSQKQPVRAVSMDESVQPNTPPAQWPG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIVAHP LNSELWVTVFGGGARTP------------------------------------VVKKTTS PTRTPP------P--------------------------------ASPSGS--------- ------------------------------------------------------------ DKKSRRFRLLSSRSGSKDESGIE------------------RDSQSSPK---HGPVVE-- --------------------------------QEATSIFKERFVPPELSIWDYLITKPSL PQSGNRIDYDSEESQGSQ-D--E-E----EDD-----D-QYEDVFDPSSPQREHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYITTPLQDETTTPGPALLRHKALFEPSNTPFRTSHHSALPVKRLWQFLVKQEEVQ ETFIRNIFTKKRDPNESGEDQTDNMKCSGMEETGNNQ-------------------TESD LSSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- DAEAKGSVGGDDFLVVHARDDFAAIHGTTPYTHSSPGTPINMPWLGGVQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGNAPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------SFCCHESGATVLLMASRQQLL ITGGRKGWISILELAHRHQRQSFLAHDSPVKALAVDPTEDCFISGSAEGNIKIWSLATQC PLYTFPNEHARQSLFRNLGTGVMQIEVGPSNHIFSCGADGTMKMRILPNRF--------- ---SV-VNSNNNH--------------NNDVKFII >ENSATEP00000027474 MNLHQVLTGAVNPGDNCFSVGSFNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPVWQPDQK----------DTSLT------------KLECQW QKTGQFALQSMVRNLAWHPT---------------------------------------- ------------------------------------GTT-LLTGSSSLQLWSN------- --------V-NGVKDE-------------------------------------------- -------------------------------------------DEEKGKQTE-------- --------EMSIGDSH-SAWRC-----------IW------------------------- --QSNTASAVNLMKFSPDGEFFATAG---------------QDDCLVKVWYSTSKWKSSV SRLFTPPEPSVSVQGELAFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLSG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------DNYASDQQSDALKCTGTSGK- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------HTIDGKTQGN TAQEFNFQEPWHFSLYRDVP---------------------------------------- ----------------------------------------------QPSVTGCLPHQQSH GHYSHKKS---NSNRP-HANALCHFHIAASINPATDIPLLPSISSLSAVDDEEPGGPFTV HWLNNKELHFTLAMEVFLQQLRGSLEQ--------------------------------- ------------QNEGSHE----------------------------------------- ------------------------------------E----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PDDEDNFDEEDNSSKPNDTQGPEAVE ---------------------------------------------------------LPL AAVEHQVDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYHPGMFRQAQVSFVSRIPV AFPAGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GTALPQTK SALISYRGQGKA-----------AP--------------------------SSSLRLSIF TPNVLMISKHDDGSLNQWAVSFAEDSAFSTVLSVSHKSRFCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEVDSILAPPEACSS-GFSQSP----------------------------- ------------------------------------------SLTRRSRPSRVSLGMVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GAY CNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEGLILG------------------------ --------------------------------------SE-------------------- ----------------------------------------------RTDGTQETLLSPHT --------------------AS---------GEL-------------------------- -------------TFSARFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAARPV--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EE--TEKDVTKASPLNSSQFNFDTFS------------------SPVTQ K-----------------SKPCTSNLQSACRLSLTTHSLYSQEMALPEGVEAISVTPSAG HLSASCSLPADRVPYLLATSCSDGKVRFWRCNVGASE----------------------- ---PCTMENLVYQWEEWPLLLEEGLPNSSAVSISGRPIGVSCCHPGRIAVAY-------- ---------RQTPNTSLKTK----SHLNS--------HRP------------STS----- ---PPTLASSPY---------NTHL--------TPALTVQQSPKLTLC------------ -------PNPL---NTRE--------------PL-----------------------VH- --------------------------IGIFQCESTGGSKWILEQIIVLD----------- ------------------------------------------------------------ ----STDPTAN------------------------------------------------- -------------------YGV---------------------------ISS-------- --------------AATS-------NMDFQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---LPNENCLGSTNKSLVHLDWVSQEDGSHVLTVGIGTKIHMYGRLSGKPPELGLSFDPT KDQS----LSRLVLLRSVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APPKPNVVIAQDTDISSSVSSIISAVRQSQEEGVSPGVPMSSLA--------------- -----------------------------------P------------------------ -------------------PRKALTRSMMSLAQKLS---GKRTA-YDLPIEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVYRAKAILSHLVKCIAGEIVALKDST-T-------- ---NPGKRFRSRTIS---AGGSTARDPKMFSK-SETSTPDYTEISSIPPLPLYALLAAD- EDTSPKP-----GKV-----------GSVSGD-----------------SGHGSS----- ------------------------------------------HIDAYDELFH--TNSIVD --------------------LDPL-DNDKEETGN-------------------------- --------------------------------------KVIDLSQYSPTHFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDSQDKSKGGETLDECGLKFLLAVRLH TFLSTSMPPAHRAQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALHKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQSSNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTDFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCIE KLQDLQLALVISRLYESEFETASTYKKILRR------------HVLGQDKQ--------- ----------------------------------IPAHEDPFLRSIAHWVLEDYSRALDT LLEQ---------PSN-----S------ENKCDTG------------------------- -------------SSSV-----------------------------------------ST CNP---------------------EVFNFYIYLRTHPLLLRRHFSSSD---KAKVG---- ------LTAECRRADSISLEERRLFFTAAYAHLQAGCPMLALEVLSKMPKVQKHSK---- -------RP--------------------------------------------------- ------------------------------------------------------------ --------------------------------------KPQDTSIAAE-LSVGSKNAQTS DPDWSLPALNGYESDGN---SLS-----NSQSDSVLSFDWSQPSMTLPDEPLELKWDSDK ED---DE-DN-EDEEE-TKNAKSDRTGDSTS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDTQDAMSP LMETVT-----------------------------------------------GEDSEDR SDF-------------------------------------IAPS---------------- --------------D--------------------------------------------- --------DILAAQLKFTACLKIMTNELRTLSTGYELDGGKLRYQLYQWLERE------- ---------------------V-------------------------------------- VALQRCCSYKPCL----------------PELSVQGDANVSGLVEEEE------------ ------------------------------------------------------------ ------------PAS--------------------------------------------- ----------------PCGDS--------------------------------------- ---------------------------Q-----------------------------RS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELTLLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSSQSVVT STSQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTANVKTVVANPIVYLTNLTHDILQTINALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDAHTY-------------------------------------S- --HVNRFTGIVYQ--------------SVLLSQKQPVRTVSMDESVQPNTSPAQWPG--- -----ISSLVCLLS-SAGEESQPGLTVLLCEILTAVFLSLFVHGMATHSCNELFRIVAHP LNSKLWVTVFGGGARIP------------------------------------VIEKPNS PTRTPP------P--------------------------------VSPSNS--------- ------------------------------------------------------------ NRKSRRFRLLSSRSGSREESGIE------------------REGPYSPK---HGSVVE-- --------------------------------QEATSIFKERFVPPELSIWDYFIAKPSL PPSENRIEYDSEESQDSQ-D--E-D----DDD-----D-EYEDVFDPNSPQKEHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTHLQDDTATPGPALLRHKALFEPSNTPFRSNHHSALPVKRLWQFLVKQEEVQ ETFIRNIFTKKLSPNESVEDQTDNMKLSGMDETGNNQ-------------------TESD LGSPRGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAEAKG-VGGDDFLVVHTRDDLVALHGTTPYTHSSPGTPINMPWLGGMQTGRGAS----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTTGNAPKPYL--TLQCHNKTAHDFVFVSSSSLIATAGLSTD NRNVCLWDTLVPPANSLVH--------------------AFYCHESGATVLSVAPRQQLL ITGGRKGWISVLELSHKHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSMATQS LLYTFPNEHARQSLFRNLGTGVMQIEVGPANHIFSCGADGTMKMRILPNRF--------- ---SV-NNNNNNY-----------GNVKNDVRFII >ENSSLDP00000025983 MNLHQVLTGAVNPGDNCFSVGNVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPVQHPRQK----------DTSLT------------KLNCQW QKTGQFVLQSMVRNLAWHPT---------------------------------------- ------------------------------------GST-LLTGSSSLQLWSN------- --------F-DGVKDE-------------------------------------------- -------------------------------------------AEERGKQA--------- --------EMSIRDSH-SAWRC-----------IW------------------------- --QSKTASPVSLMKFSPDGEFFATAG---------------QDDCLVKVWYSTSKWKSGV SRLFTPPEPSVSVQGELAFSFVYLAHPRSVTGFSWRKTSMYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDCLLSG----------------------------------- -------------------------LH--------------------------------- ------------------------------------------------------------ ---------------------------------------NNHVPGPHSDTLRCAGPTRK- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------HTCNGKTQGK TAQEMNFQELWHSSLYRDVP---------------------------------------- ----------------------------------------------QPSLTGGLPHHQSR -HYNHKRS---NSNTP-HANALCHFHIAASINPATDIPLLPSISSLSGVDDEEPGGPFTV HWLNNKELHFTLAMEVFLQQLRGSLEQ--------------------------------- ------------QNECSHE----------------------------------------- ------------------------------------E----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PEDEDNFDEEGN-SRPGDPQGPEAVE ---------------------------------------------------------LPL AAVEHQVDVLVEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQAQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPL-------------GSTLPQTK SALISYVGQGKP-----------AP--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEVDSILAPPEACST-GFSHST----------------------------- ------------------------------------------SLPRGSRSSRVSLGVVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDTITD--------------------F------------ ------------------QGKETQLLHVFEEDLILG------------------------ --------------------------------------SE-------------------- ----------------------------------------------RTESTQD------T PDSSP--------------AAS---------GDP-------------------------- -------------TFSARFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAARPV--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EETMTEKDATTASPINSSQFNYDTFT------------------SPVIQ K-----------------SKTCTSNLQSACRLSLTTHRLYSQEMALPEGVEAISVTPSAG HLSASCSLPAGRVPYLLATSCSDGKVRFWRCKVVTTE----------------------- ---PFSMDTLLYQWEEWPLLVEERLPNSSAVSVQGRPIEVSCCHTGRIAVAY-------- ---------RQTPNT------------------------PLNSTPHLNPHGLLTS----- ---PPTLASSPY---------NTHL--------TPTLTVQ-------------------- ----------------RSPNLTASPNLATIRGPL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----STDPTAN------------------------------------------------- --SGMNSSTNGNASIPSNV----------------------------------------- ---------------------------DFS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---LPNENCLGSTSKSLVHLDWVSQEDGSHVLTVGIGTKIYMYGRLSGKPPELGLSSEAN RDQI----LSRLVLLRSVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -TPPKPNAAITQDTDISSSVSSIISAVRQSQEEGPSPGAPMSSLA--------------- -----------------------------------P------------------------ -------------------PKKALTRSMMSLAQKLS---GKRTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVALKDSS-N-------- ---NPEKRLRSRTIS---AGGSTARDPKMFSKGVENSTPDYTEISSIPPLPLYALLAAD- EDTSPKP-----DKV-----------GSVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPSIVD --------------------LDPL-DNDQEQTSN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTSMEQMSLMALADTIATTSTDLKDSQGKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQRSNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETASTYKKILQR------------RVLGQDKQ--------- ----------------------------------IPAHQDPFLRSMAHWVLEDYSRALDT LLEQ---------PAN-----SNSSGSSESKCDSG------------------------- -------------SSSV-----------------------------------------SP CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSD---KAKVG---- ------LTAEGRRADSVSLEERRLFFTAAYAHLHAGCPMLALEVLSKMPKVHKHSKLLNQ EDTGITG----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSKNGQAS DPDWAQPALNGYESDGN---SLS-----NSKSDSVLSFDWSQPSVTLPDEPLELKWDSDK DD---EE-DY-EDEEE-TKNGKSGRTADSSS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDTQDAMSP LMETVT-----------------------------------------------GEDSEDG NDF-------------------------------------IAPS---------------- --------------D--------------------------------------------- --------DILAAQLKFTACLKILTNELRTLSTGYELDGGKLRYQLYQWLERE------- ---------------------V-------------------------------------- VALQRCCSYKPCL----------------PELSVQGDAPVSGLVEEEQ------------ ------------------------------------------------------------ ------------PGS--------------------------------------------- ----------------PRGDS--------------------------------------- ---------------------------Q-----------------------------RS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSIQSVVT SSSQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTANVKTVVANPIVYLTNLTHDILQTINALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDGHTY-------------------------------------S- --HVNHFTGIVYQ--------------SVLLSQKHPVRTVSMDESVQPNTSPAQWPG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIVAHP LNSKLWVTVFGGGARIP------------------------------------VIEKPNS PMRTPP------P--------------------------------ASPSGS--------- ------------------------------------------------------------ DRKSRRFRLLSSRSGSKEESGIE------------------REGPSSPK---HVPVVE-- --------------------------------QEAASIFKERFVPPELSIWDYFIAKPLL PPSENRIVYDSEESQGSQ-D--E-D----EDG-----D-EYEDVFDPNSPQREHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQLLQKRLEIFG GPPSKYISTHLQDETATSGPALLRHKVLFEPSNTPFRTNHHSALPVKRLWQFLVKQEEVQ ETFIRNIFTKKRDPNESVEDQTDNMKCSGMDETGNHQ-------------------TESD QGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAEAKG-VGGDDFLVVHTRDDFAALHGTTPYTHSSPGTPINMPWLGGVQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIIDADGGLSLWQTNTSGNTPKPFL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHESGATVLAMAPRQQLL ITGGRKGWISILELPHKHQRQSFQAHDSPVKALAVDPIEDCFISGSAEGNIKVWSLATQS LLYAFPNEHARQSLFRNLGTGVMQIEVGPANHIFSCGADGTMKMRILPNRF--------- ---SV--V-NNNH-----------GNLKNDVNFII >ENSSDUP00000001175 MNLHQVLTGAVNPGDNCFSVGNVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPVQHPRQK----------DTSLT------------KLNCQW QKTGQFVLQSMVRNLAWHPT---------------------------------------- ------------------------------------GST-LLTGSSSLQLWSN------- --------F-DGVKDE-------------------------------------------- -------------------------------------------AKERGKQA--------- --------EMSIRDSH-SAWRC-----------IW------------------------- --QSKTASPVSLMKFSPDGEFFATAG---------------QDDCLVKVWYSTSKWKSGV SRLFTPPEPSVSVQGELAFSFVYLAHPRSVTGFSWRKTSMYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDCLLSG----------------------------------- -------------------------LH--------------------------------- ------------------------------------------------------------ ---------------------------------------NNHVPGPHSDTLRCAGPTRK- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------HTCNGKTQGK TAQELNFQESWHSSLYRDVP---------------------------------------- ----------------------------------------------QPSLTGGLPHHQSR -HYNHKRS---NSNTP-HANALCHFHIAASINPATDIPLLPSISSLSGVDDEEPGGPFTV HWLNNKELHFTLAMEVFLQQLRGSLEQ--------------------------------- ------------QNECSHE----------------------------------------- ------------------------------------E----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PEDEDNFDEEGN-SRPGDPQGPEAVE ---------------------------------------------------------LPL AAVEHQVDVLVEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQAQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPL-------------GSTLPQTK SALISYVGQGKP-----------AP--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEVDSILAPPEACST-GFSHST----------------------------- ------------------------------------------SLPRGSRSSRVSLGVVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDTITD--------------------F------------ ------------------QGKETQLLHVFEEDLILG------------------------ --------------------------------------SE-------------------- ----------------------------------------------RTEGTQD------T PDSSP--------------AAS---------GEP-------------------------- -------------TFSARFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAARPV--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EETMTEKDATTASPVNSSQFNYDKFT------------------SPVTQ K-----------------SKTCTSNLQSACRLSLTTQRLYSQEMALPEGVEAISVTPSAG HLSASCSLPAGRVPYLLATSCSDGKVRFWRCKVVATE----------------------- ---PFSMDTLLYQWEEWPLLVEERLPNSSAVSVQGRPIEVSCCHTGRIAVAY-------- ---------RQTPNT------------------------PLNSTPHLNPHGLLTS----- ---PPTLASSPY---------NTHL--------TPTLTVQ-------------------- ----------------RSTNLTASPNLATIRGPL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----STDPTAN------------------------------------------------- --CGMSSSTNGNASIPSNV----------------------------------------- ---------------------------DFS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---LPNENCLGSTSKSLVHLDWVSQEDGSHVLTVGIGTKIYMYGRLSGKPPELGLSSDAN RDQI----LSRLVLLRSVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -TPPKPNAAITQDTDISSSVSSIISAVRQSQEEGLSPGAPMSSLA--------------- -----------------------------------P------------------------ -------------------PKKALTRSMMSLAQKLS---GKRTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVALKDSS-N-------- ---NPEKRLRSRTIS---AGGSTARDPKMFGKGVENSTPDYTEISSIPPLPLYALLAAD- EDTSPKP-----DKV-----------GSVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPSIVD --------------------LDPL-DNDQEQTSN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTSMEQMSLMALADTIATTSTDLKDSQGKSKGGETLDDCGLKFLLAVRLH TFLSTSLPPAHRAQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQRSNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETASTYKKILQR------------RVLGQDKQ--------- ----------------------------------IPAHQDPFLRSMAHWVLEDYSKALDT LLEQ---------PAN-----SNSSGSSESKCDSG------------------------- -------------SSSV-----------------------------------------SP CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSD---KAKVG---- ------LTAEGRRADSISLEERRLFFTAAYAHLHAGCPMLALEVLSKMPKVHKHSKLLNQ EDTGITG----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSKNGQAS DPDWAQPALNGYESDGN---SLS-----NSKSDSVLSFDWSQPSVTLPDEPLELKWDSDK DD---EE-DY-EDEEE-TKNGKSSKAADSSS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDTQDAMSP LMETVT-----------------------------------------------GEDSEDR NDF-------------------------------------IAPS---------------- --------------D--------------------------------------------- --------DILAAQLKFTACLKILTNELRTLSTGYELDGGKLRYQLYQWLERE------- ---------------------V-------------------------------------- VALQRCCSYKPCL----------------PELSVQGDAPVSGLVEEEQ------------ ------------------------------------------------------------ ------------PGS--------------------------------------------- ----------------PRGDS--------------------------------------- ---------------------------Q-----------------------------RS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSIQSVVT SSSQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTANVKTVVANPIVYLTNLTHDILQTINALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDGHTY-------------------------------------S- --HVNHFTGIVYQ--------------SVLLSQKHPVRTVSMDESVQPNTSPAQWPG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIVAHP LNSKLWVTVFGGGARIP------------------------------------VIEKPNS PMRTPP------P--------------------------------ASPSGS--------- ------------------------------------------------------------ DRKSRRFRLLSSRSGSKEESGIE------------------REGPSSPK---HVPVVE-- --------------------------------QEAASIFKERFVPPELSIWDYFIAKPLL PPSENRIVYDSEESQGSQ-D--E-D----EDG-----D-EYEDVFDPNSPQREHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQLLQKRLEIFG GPPSKYISTHLQDETATPGPALLRHKVLFEPSNTPFRTNHHSALPVKRLWQFLVKQEEVQ ETFIRNIFTKKRDPNESVEDQTDNMKCSGMDETGNHQ-------------------TESD QGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAEAKG-VGGDDFLVVHTRDDFAALHGTTPYTHSSPGTPINMPWLGGVQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGNTPKPFL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHESGATVLAMAPRQQLL ITGGRKGWISILELPHKHQRQSFQAHDSPVKALAVDPIEDCFISGSAEGNIKVWSLATQS LLYAFPNEHARQSLFRNLGTGVMQIEVGPANHIFSCGADGTMKMRILPNRF--------- ---SV--V-NNNH-----------GNLKNDVNFII >ENSLCAP00010009368 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQVRV------MEW------------C------SVLLCPQVDIQTR----- ---------------------------------------------------------MFP KYHTVL------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----TASPVSLMKFSPDGEFFATAG---------------QDDCLVKVWYSTSKWKSGV SRLFTPPEPSVSVQGELAFSFVYLAHPRSVTGFSWRKTSMYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLSG----------------------------------- -------------------------LH--------------------------------- ------------------------------------------------------------ ---------------------------------------NNHAPGQHSDALRCAGSTRK- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------HTCNGKTQGK T----------------------------------------------------------- -----------------------------------------------PSLTSCLPHHQSR -HYNHKKS---SSNMP-HANALCHFHIAASINPATDIPLLPSISSLSAVDDEEPGGPFTV HWLNNKELHFTLAMEVFLQQLRGSLEQ--------------------------------- ------------QSECSHEG--------------------------------------TE KYLD------QTVEL--------------------S------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------L AAVEHQVDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQAQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQTK SALISYGGQGKA-----------AP--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEVDSILAPPEACSS-GFSHPT----------------------------- ------------------------------------------SLPRRSRPSRVSLGVVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEDLILGR----------EKTESL------- ----ISNI------------YTMFKHSSLIFSVCF--C---------------------- ------------------------------------------------------------ -------------------AAS---------GEP-------------------------- -------------TFSARFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAARPI--------T---------- --------MG---------------------------------GYFEQKTYS-------- SQDQYF------------------------------------------P----------- ------------------------------------------------------------ ---------------------L-------------------------------------- ----SLVSPAA------------------------------------------------Q K-----------------SKTCTSNLQSACRLSLTTHRLYSQEMALPEGVEAISVTPSAG HLSASCSLPAGRVPYLLATSCSDGKVRFWRCNVVATE----------------------- ---SSSMDSLLYHWEEWQLLVEERLPNSSAVSVPGRPIEVSCCHTGRIAVAYSHNLANTK --------E--------------------------------------------------- ------------------------------------------------------------ --------------------------------PL-----------------------VH- --------------------------ISIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----STDPTAN------------------------------------------------- --CGISNSTTGGASVPSKV----------------------------------------- ---------------------------DFS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---LPNENCLGFTSKSLVHLDWVSQEDGSHVLTVGIGTKIYMYGRLSGKPPELGLSSDAS RDQS----LSRLVLLRSVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -TPPKPNVAIAQDIDISSSVSSIISAVRQSQEEGLSPGAPMSLLA--------------- -----------------------------------P------------------------ -------------------PKKALTRSMMSLAQKLS---GKRTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVALKDST-T-------- ---NPEKRVRSRTIS---AGGSTARDPKMFSK-VENSTPDYTEISSIPPLPLYSLMAAD- EDTSPKP-------------------GDVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPSIVD --------------------LDPL-DSDQEEPGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDSQGKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQRSNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTDFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETSSTYKKILQR------------HVLGQDKQV-------- -----------------------------HRG-CIPAHQDPFLRSMAHWVLEDYSRALDT LLEQ---------PAN-----S-------------------------------------- -------------SLSV-----------------------------------------ST CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSD---KAKVG---- ------LTAEGRRADSISLEERRLFFTAAYAHLQAGCPMLALEVLSKMPKVRKHSKLLNQ EDTGITA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------EQLSVGSKNGQAS DPDWSQPALNGYESDGN---SLS-----NSKSDSVLSFDWSQ------------AWDSDK DD---DE-DEDEDQEE-TKNGKSSRTADSSS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDTQDAMSP LMGTVT-----------------------------------------------GEDSEDS SDF-------------------------------------IAPS---------------- --------------D--------------------------------------------- --------DILAAQLKFTACLKIMTNELRTL---------------------E------- ---------------------V-------------------------------------- VALQHCCSYKPCL----------------P----------------DA------------ ------------------------------------------------------------ ------------PGS--------------------------------------------- ----------------PRGDS--------------------------------------- ---------------------------Q-----------------------------RS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DESIQPVVT LSSQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTSNVKTVVANPIVYLTNLTHDILQTINALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCLLLFY---HSY-------------------------------------S- --TVNHFTGIVYQ--------------SVLLSQKQPVRTVSMDESVQPNTSPAQWPG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIVAHP LNSKLWVTVFGGGARTP------------------------------------VIEKPNS PARTPP------P----------------------------------------------- ------------------------------------------------------------ -----------------EESGIE------------------REGPISPK---HVPVVE-- --------------------------------QEATSIFKERFVPPELSIWDYFIAKPFL PPSENRIEYDSEESQGSQ-D--E-D----EDD-----D-EFEDVFDPNSPQREHSNHNSY SWCLMRLAMVQLVLVKLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTHLQDETSTPGPALLRHKVLFEPSNTPFRTNHHSALPVKRLWQFLVKQEEVQ ETFIRNIFTKKRDPNE----------------------------------------TESD LGCPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAEAKG-VGGDDFLVVHARDDFAALHGTTPYTHSSPGTPINMPWLGGLQTGRGAS----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGNAPKPFL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHESGATVLAMAPRQQLL ITGGRKGWISVLELPHRHQRQSFQAHDSPVKALAVDPIEDCFISGSAEGNIKVWSLATQC LLYAFPNEHARQSLFRNLGTGVMQIEVGPTNHIFSCGADGTMKMRILPNRY--------- ---SV--VNNNNH-----------SNLKNDVKFII >ENSAOCP00000027474 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPVQHPDQK----------DTSLT------------KWNCQW QKTGQFVLQSMVRNLAWHPT---------------------------------------- ------------------------------------GST-LLTGSSSLQLWST------- --------A-DGGKDE-------------------------------------------- -------------------------------------------AKETEKPT--------- --------EMTIRDSC-SAWRC-----------IW------------------------- --ESKTATSVSLMKFSPDGEFFATAG---------------QDDCLVKVWYSTSKWKSGV SRLFTPPDPSVTVQGELAFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLSG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------NNHTSGQQSETHRCAGPSRK- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------NNCNGKTQGR AAQELNFQEPWHSSFNRDVP---------------------------------------- ----------------------------------------------VPSLTGCLPHNQSR -HYNHKSS---SNSMP-HANALCHFHIAASINPATDIPLLPSISSLNAMDDEEPGGPFTV HWLNNKELHFTLAMEVFLQQLRGSLEQ--------------------------------- ------------QNECSNE----------------------------------------- ------------------------------------D----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PDNEDNF-EEDSSSRPSDQQGLEAVE ---------------------------------------------------------LPL AAVEHQVDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQAQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQTK SALISYGGHGKA-----------AA--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADNILAPPEAYSS-GLSHTT----------------------------- ------------------------------------------SLSRGSRPSRVSLGAVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GAY CNSPSACFVASDGLSLRLYQAVIEAKKLLSELSNPEISK--------------------S VGEVFNIISQQSTAKPGCIIELDVITD--------------------F------------ ------------------QGKETQLLHVFEEDLIL------------------------- -------------------------------------GSE-------------------- ----------------------------------------------RTKNAQENPSSPHN --------------------AS---------SEP-------------------------- -------------AFSARFFLVVVELTPTGRSVLHMW----------------------- --------------------------------HLQLAARPV--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EETHTKKDSTTACPMNSSQFIFDSLS------------------SPVSQ K-----------------SKSCTSNLQSACRLSLTTHRLYSQEMALPEGVEAISVTPSAD HLSSSCSLPAGRVPYLLATSCSDGKVRFFRCNVEIPE----------------------- ---PSSLNNLVYQWEEWPLLVEERFPSSSAVSVPGLPVEVSCCHTGRIAVAY-------- ---------RQIPNT------------------------PLNSTPHLPSHGLLTS----- ---PPTLASTPFVYYTTT---NAHP--------TPSLTVQYSP----------------- -------------------NLTLSPNPANTREPL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----STDPTANYAISNYMPGHD------------NIPS--------SM------------ ------------------------------------------------------------ ---------------------------DFS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---IPNENCLGSTSKSLVHLDWVSQEDGSHVLTIGIGTKLYMYGRLAGKPPELGLSSDAT RDQS----LSRLVLLRSVNLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APAKSNVTVAQDTDISSSISSIVSAVRQCQEEGLSPAAPS-LLA--------------- -----------------------------------P------------------------ -------------------PKKALTRSMMSLAQKLS---GKRTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVALKDST-T-------- ---NAEKRVRSRTIS---AGGSTARDRKMFGK-TERSSPDYTEISSIPPLPLYALLAAD- QDS-PNP-----DKV-----------GSVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPNMVD --------------------LDPL-DSDQEETGN-------------------------- --------------------------------------KVIDLSQYSPTDFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDCQGKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRVQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFHNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETASTYKKILQR------------HVLGHDKQ--------- ----------------------------------IPAHQDPFLRSMAHWVLEDYSRALDT LLEH---------PSN-----SSSSRSTESKCDTG------------------------- --------------PFV-----------------------------------------ST CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSD---KAKVG---- ------LTAEGRRADSISLDERRLFFTAAYAHLHAGCPMLALEVLSKMPKVRKHSKPPDQ EDTGIAA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSRS--AS EPDWSQPALNGYESDGN---SLS-----NSQSDSVLSFDWSQPSLTLPDEPLELKWDSDK DDGD-DD-DGDEDEEE-TKNGKSGRTADSS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDTQESMST LTETAV-----------------------------------------------GEVAEDS NDF-------------------------------------IAPS---------------- --------------D--------------------------------------------- --------DILVAQMKFTACLKIMTNELRTLSTGYELDGGKLRSQLYQWLERE------- ---------------------V-------------------------------------- VALQHCCSYKPCL----------------PELSVQGDGPVSGLVEEEQ------------ ------------------------------------------------------------ ------------PGS--------------------------------------------- ----------------PRGDS--------------------------------------- ---------------------------Q-----------------------------KS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSIQSVVT SSSH-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTANVKTVVANPIIYLTNLTHDILQTINALDSPPHPDVVTNEIYVMHTLA ASLSACIYQCL----CDGHTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQPLRTVSMDESVQPNTSPAQWPG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIVAHP LNSKLWVTVFGGGARTP------------------------------------VIEKPCS PARTPP------P--------------------------------ASPSGS--------- ------------------------------------------------------------ EKKSRRFRLLSSRSGSKEESGTD------------------REGPASPR---HGHVVE-- --------------------------------QEATSIFKERFVPPELSIWDYFIAKPPL PPSESRIEYDSEDSQGSQ-D--E-D----DDD-----D-EYEDVFDPNSPPREHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYVSTHFHDETATPGPALLRHKALFEPTNTPFRTSHHSALPVKRLWQFLVKQDEVQ ETFIRNIFTKKQGINQSVEDQTDNMKCSGMDETGNNQ-------------------TESD LGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAEAKG-VGGDDFLVVHARDDFATLHGTTPYTHSSPGTPISVPWLGGLQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGNAPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHESGATVLSMAPRQQLL ITGGRKGWISVLELPHRHQRQSFQGHDSPVKALAVDPTEDCFISGSAEGNIKVWSLATQC LLYTFTNEHARQSLFRNLGTGVMQIEVGPANHIFSCGADGTMKMRILPNRF--------- ---SV--V-NNNH-----------GNLKNEVKFFI >ENSAPEP00000028010 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPVQHPDQK----------DTSLT------------KWNCQW QKTGQFVLQSMVRNLAWHPT---------------------------------------- ------------------------------------GST-LLTGSSSLQLWST------- --------A-DGEKDE-------------------------------------------- -------------------------------------------AKETEKPT--------- --------EMTIRDSC-SAWRC-----------IW------------------------- --ESKTATSVSLMKFSPDGEFFATAG---------------QDDCLVKVWYSTSKWKSGV SRLFTPPDPSVTVQGELAFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLSG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------NNHTSGQQSETHRCAGPSRK- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------NNCNGKTQGR AAQELNFQEPWHSSFNRDVP---------------------------------------- ----------------------------------------------VPSLTGCLPHNQSR -HYNHKRS---SNSMP-HANALCHFHIAASINPATDIPLLPSISSLNAMDDEEPGGPFTV HWLNNKELNFTLAMEVFLQQLRGSLEQ--------------------------------- ------------QNECSNE----------------------------------------- ------------------------------------D----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PDNEDNF-EEDSSSRPSDQQGLEAVE ---------------------------------------------------------LPL AAVEHQVDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQAQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQTK SALISYGGHGKA-----------AA--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPETDNILAPPEAYSS-GLSHTT----------------------------- ------------------------------------------SLSRGSRPSRVSLGAVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GAY CNSPSACFVASDGLSLRLYQAVIEAKKLLSELSNPEISK--------------------S VGEVFNIISQQSTAKPGCIIELDVITD--------------------F------------ ------------------QGKETQLLHVFEEDLIL------------------------- -------------------------------------GSE-------------------- ----------------------------------------------RTENAQDNPSSPHN --------------------AS---------SEP-------------------------- -------------AFSARFFLVVVELTPTGRSVLHMW----------------------- --------------------------------HLQLAARPV--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EETHTKKDSTTACPMNSSQFIFDSLS------------------SPISQ K-----------------SKSCTSNLQSACRLSLTTHRLYSQEMALPEGVEAISVTPSAD HLSSSCSLPAGRVPYLLATSCSDGKVRFFRCNVEIPE----------------------- ---PSSLNNLVYQWEEWPLLVEERFPSSSAVSVPGLPVEVSCCHTGRIAVAY-------- ---------RQIPNT------------------------PLNSTPHLPSHGLLTS----- ---PPTLASTPFLYYTTT---NAHP--------TPSLTVQYSP----------------- -------------------NLTLSPNPANTREPL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----STDPTANYAISNYMPGHD------------NIPS--------SM------------ ------------------------------------------------------------ ---------------------------DFS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---IPNENCLGSTSKSLVHLDWVSQEDGSHVLTIGIGTKIYMYGRLAGKPPELGLSSDAT RDQS----LSRLVLLRSVNLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APAKSNVTVAQDTDISSSISSIVSAVRQCQEEGLSPAAPS-LLA--------------- -----------------------------------P------------------------ -------------------PKKALTRSMMSLAQKLS---GKRTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVALKDST-T-------- ---NAEKRVRSRTIS---AGGSTARDRKMFGK-TERSSPDYTEISSIPPLPLYALLAAD- QDT-PNP-----DKV-----------GSVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPNMVD --------------------LDPL-DSDQEETGN-------------------------- --------------------------------------KVIDLSQYSPTDFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDCQGKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRVQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETASTYKKILQR------------HVLGHDKQ--------- ----------------------------------IPAHQDPFLRSMAHWVLEDYSRALDT LLEH---------PSN-----SSSPRSTESKCDTG------------------------- --------------PFV-----------------------------------------ST CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSD---KAKVG---- ------LTAEGRRADSISLDERRLFFTAAYAHLHAGCPMLALEVLSKMPKVRKHSKPPDQ EDTGIAA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSRS--AS EPDWSQPALNGYESDGN---SLS-----NSQSDSVLSFDWSQPSLTLPDEPLELKWDSDK DDGD-DD-DGDEDEEE-TKNGKSGRTADSS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDTQEAMST LTETAV-----------------------------------------------GEVAEDS NDF-------------------------------------IAPS---------------- --------------D--------------------------------------------- --------DILVAQMKFTACLKIMTNELRTLSTGYELDGGKLRSQLYQWLERE------- ---------------------V-------------------------------------- VALQHCCSYKPCL----------------PELSVQGDGPVSGLVEEEQ------------ ------------------------------------------------------------ ------------PGS--------------------------------------------- ----------------PRGDS--------------------------------------- ---------------------------Q-----------------------------KS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSIQFVVT SSSH-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTANVKTVVANPIIYLTNLTHDILQTINALDSPPHPDVVTNEIYVMHTLA ASLSACIYQCL----CDGDTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQPLRTVSMDESVQPNTSPAQWPG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIVAHP LNSKLWVTVFGGGARTP------------------------------------VIEKPCS PARTPP------P--------------------------------ASPSGL--------- ------------------------------------------------------------ EKKSRRFRLLSSRSGSKEESGTD------------------REAPASPR---HGHVVE-- --------------------------------QEATSIFKERFVPPELSIWDYFIAKPPL PPSESRIEYDSEDSQGSQ-D--E-D----DDD-----D-EYEDVFDPNSPQREHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTHLHDETATPGPALLRHKALFEPTNTPFRTSHHSALPVKRLWQFLVKQDEVQ ETFIRNIFTKKQGINQSVEDQTDNMKCSGMDETGNNQ-------------------TESD LGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAEAKG-VGGDDFLVVHARDDFATLHGTTPYTHSSPGTPISVPWLGGLQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGNAPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHESGATVLSMAPRQQLL ITGGRKGWISVLELPHRHQRQSFQGHDSPVKALAVDPTEDCFISGSAEGNIKVWSLATQC LLYTFTNEHARQSLFRNLGTGVMQIEVGPANHIFSCGADGTMKMRILPNRF--------- ---SV--V-NNNH-----------GNLKNEVKFFI >ENSAPOP00000002269 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGAKNGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPVQHPDQK----------DTSLT------------KWNCQW QKTGQFVLQSMVRNLAWHPT---------------------------------------- ------------------------------------GST-LLTGSSSLQLWST------- --------A-DGVKDE-------------------------------------------- -------------------------------------------AKETEKQT--------- --------EMTIRDAR-SAWRC-----------IW------------------------- --ESKTATSVSLMKFSPDGEFFATAG---------------QDDCLVKVWYSTSKWKSGV SQLFTPPEPSVTVQGELAFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLSG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------NNHTSGQHSETHRCAGASRK- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------NNCNGKTQGR TAQELNFQEPWHSSFNRDVP---------------------------------------- ----------------------------------------------VPSLTGCQPHHQSR -HYNHKKS---NNTMP-HANALCHFHIAASINPATDIPLLPSISSLNSMDDEEPGGPFTV HWLNNKELHFTLAMEVFLQQLRGSLEQ--------------------------------- ------------QNECSNE----------------------------------------- ------------------------------------D----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PDNEDNF-EDDSSSRPSDQQGLEAVE ---------------------------------------------------------LPL AAVEHQVDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQAQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQTK SALISYGGHGKA-----------AA--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADNILAPPETYST-GLSHTT----------------------------- ------------------------------------------SLSRGSRPSRVSLGAVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GAY CNSPSACFVASDGLSLRLYQAVIEAKKLLSELSNPEISK--------------------S VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEDLIL------------------------- -------------------------------------GSE-------------------- ----------------------------------------------RTENAQETPGSPHN --------------------AS---------SEP-------------------------- -------------AFSARFFLVVVELTPTGRSVLHMW----------------------- --------------------------------HLQLAARPV--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EETQTKKNSTTDCPVNSSQFIFDSLS------------------SPISQ K-----------------SKSCTSNLQSACRLSLTTHRLYSQEMALPEGVEAISVTPSAD HLSSSCSLPAGRVPYLLATSCSDGKVRFFRCNVETPE----------------------- ---PSSLNNLVYQWEEWPLLVEERFPSSSAVSVPGLPVEVSCCHTGRIAVAY-------- ---------RQIPNT------------------------PLNSTPRLPSHGLLTS----- ----PKLASSPFVHYTTT---NVHP--------TPTLTVEHSP----------------- -------------------NLILSPNPANTREPL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----STDPTANYAISNYMPGHD------------NIP---------SM------------ ------------------------------------------------------------ ---------------------------DFS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---VPNENYLGSTSKSLVHLDWVSQEDGSHVLTIGIGTKIYMYGRLAGKPPELGLSSDAT RDQS----LSRLVLLRSVNLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APAKPNVTVAQDTDISSSISSIVSAVRQCQEEGLSPAAPTPFLA--------------- -----------------------------------P------------------------ -------------------PKKALTRSMMSLAQKLS---GKRTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVALKDTT-T-------- ---NPEKRVRSRTIS---AGGSTARDRKMFSK-TESSSPDYTEISSVPPLPLYALLAAD- QDT-PNP-----DKV-----------SSVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPNMVD --------------------LDPL-DSDQEETGN-------------------------- --------------------------------------KVIDLSQYSPTDFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDCQGKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRVQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQRSNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETASTYKKILQR------------HVLGHDKQ--------- ----------------------------------IPAHQDPFLRSMAHWVLEDYSRALDA LLEQ---------PSN-----SSRSRPTESKCDSG------------------------- --------------PFV-----------------------------------------ST CNP---------------------EVFNFYIYLRTHPLLLRRHFGSSD---KAKVG---- ------LTAEGRRADSISLDERRLFFTAAYAHLHAGCPMLALEVLSKMPKVRKHSKPPDQ EETSIAA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSDGSRS--AS EPDWSQPALNGYESDGN---SLF-----NSRSDSVLSFDWSQPSLTLPDQPLELKWDSDK ------D-DDDEDEEE-AKNGKSGRTADSS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDMQEAMSA VTETAV-----------------------------------------------GEVAEDS NDF-------------------------------------ITPS---------------- --------------D--------------------------------------------- --------DILVAQMKFTACLKIMTNELRTLSTGYELEGGKLRYQLYQWLERE------- ---------------------V-------------------------------------- VALQHCCSYKPCL----------------PELSVQGDGPVSGLVEEEQ------------ ------------------------------------------------------------ ------------PGS--------------------------------------------- ----------------PRGDS--------------------------------------- ---------------------------Q-----------------------------KS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSIQSVVT SSSH-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTANVKTVVANPIIYLTNLTHDILQTINALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDGHTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQPLRTVSMDESVQPNTSPAQWPG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIVAHP LNSKLWVTVFGGGARTP------------------------------------VIEKPCS PARTPP------P--------------------------------VSPSGS--------- ------------------------------------------------------------ EKKSRRFRLLSSRSGSKEESGTD------------------RDGPASPR---HGHVVE-- --------------------------------QEATSIFKERFVPPELSIWDYFIAKPPL PPSENRIEYDSEDSLGSQ-D--E-D----DDD-----D-EYEDVFDPNSPQREHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTHLHDETATPGPALLRHKALFEPTNTPFRTSHHSALPVKRLWQFLVKQDEVQ ETFIRNIFTKKPGTNQSVEDQTDNMKCSGMDETGNNQ-------------------TESD LGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAEAKG-VGGDDFLVVHARDDFATLHGTTPYTHSSPGTPINVPWLGGMQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGNAPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHESGATVLSMAPRQQLL ITGGRKGWISVLELPHRHQRQSFQGHDSPVKALAVDPTEDCFISGSAEGNIKVWSLATQC LLYTFTNEHARQSLFRNLGTGVMQLEVGPANHIFSCGADGTMKMRILPNRF--------- ---SV--V-NNNY-----------SNLKNEVKFFI >ENSSPAP00000000264 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQVRVIELSPKL--------------------------------------- ------------------------------------------------------------ --------------------------------------------------------NCQW QKTGQFVLQSMVRNLAWHPT---------------------------------------- ------------------------------------GST-LLTGSNSLQLWSN------- --------A-NGVKDE-------------------------------------------- -------------------------------------------AEETEQQT--------- --------KMTIRDSR-SAWRC-----------IW------------------------- --ESKTASSVSLMKFSPDGEFFATAG---------------QDDCLVKVWYSTSKWKSGV SRLFTPPDPSVTVQGELAFSFVYLAHPRSVTGFSWRKTSKYMPRR--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLSG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------NNHTSGQHGEMQKCAGPSRKI C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------VS---------- ----LNFQESWHSSFHRDIP---------------------------------------- ----------------------------------------------LPSLTGCLPHHQSR -HYNHKRS---SNNIP-HANALCHFHIAASINPATDIPLLPSISSLNATDDEEPGGPFTV HWLNNKELHFTLAMEVFLQQLRGSLEQ--------------------------------- ------------QNECSNE----------------------------------------- ------------------------------------D----------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------DNSSRPSDPQGLEAVE ---------------------------------------------------------LPL AAVEHQVDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQAQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQTK SALISYGGHGKA-----------AA--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPDADNILAPPEACPS-GFSHTT----------------------------- ------------------------------------------SLSRGSRPSRVSLGAVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GAY CNSPSACFVASDGLSLRLYQAVIEAKKLLSELSNPEISK--------------------S VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEDLILA------------------------ ------------------------SHSLLTFSVCFPA----------------------- ------------------------------------------------------------ --------------------AS---------SQP-------------------------- -------------AFSARFFLVVVELTPTGRSVLHMW----------------------- --------------------------------HLHLAARPVAMVLRETS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------PVNSSKFIFDTVS------------------SPITQ K-----------------SKSCTSNLQSACRLSLTTHRLYSQEMALPEGVEAISVTPSAD HLSSSCSLPAGRVPYLLATSCSDGKVRFFRCNVETPE----------------------- ---PCSLNNLVYQWEEWPLLVEERFPSSSAVSVPGLPVEVSCCHTGRIAVAY-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPNPANTREPL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----STDPTASYAVSN-------------------------------MTG---------- STD-----------IPSNI----------------------------------------- ---------------------------DFS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---IPNENCLGSTSKSLVHLDWVSQEDGSHVLTVGIGTKIYMYGRLAGKPPELGLSSDAT RDQS----LSRLVLLRSVNLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APPKPNVTVAQDTDISSSISSIVSAVRQCQEEGLSPAAPNALLA--------------- -----------------------------------P------------------------ -------------------PKKALTRSMMSLAQKLS---GKRTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVPLKDNT-A-------- ---NPEKRVRSRTIS---AGGSTARDRKMFGK-AEGSATDYTEISSVPPLPLYALLAAD- EDT-PNP-----DKV-----------GSVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPNMVD --------------------LDPL-DSEQEEAGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDCQGKSKGGETLDECGLKFLLAVRLH TFLSTSVPPAHRVQLLQQG-------------LSTCHYAWAFHSDAEEELLNMLPALQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLALKKKAVVWGLY RSQKNVKMTEFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETASTYKKILQR------------HVLGHDKQV-------- -----------------------------HRV-CIPAHKDPFLRSMAHWVLEDYSRALDT LLEQ---------PAN-----SSS------------------------------------ ----------------V-----------------------------------------ST CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSD---KAKVG---- ------LTAEGRRADSISLDERRLFFTAAYAHLHAGCPMLALEVLSKMPKVRKHSKLPDQ GDAGTAA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSRS--AS EPDWSQPALNGYESDGN---SLS-----NSQSDSVLSFDWSQPSLTLPDEPLELKWDSDK DDGDNDD-DDDADEDE-TKNGKSGKTADSSSVFQD-----------AQE----------- ---------------------------------------------AT------------- ------------------------------------------------------------ ---------PAAGE---------------------------------------------- -----------------------------------------------DP----------- ---------------------------------------------------------EDS SDF-------------------------------------IAPS---------------- --------------D--------------------------------------------- --------DILVAQLKFTACLKIMTNELRTLSTGYELDGGKLRYQLYQWLERELFLTLGD FCLNTGQLRYADMFTLMLIDLV-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RRHWLQTN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ------------------------------------------------------------ -------------------------------------------------------QSVAT SSPQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTANVKTVVANPIIYLTNLTHDILQTITALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDGQTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQPLRTVSMDESVQPNTSPAQWPG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIVAHP LNSKLWVTVFGGGARTP------------------------------------VIEKPCS PARTPP------P----------------------------------------------- ------------------------------------------------------------ ------------------ESGMD------------------REAPASPR---HCPIVE-- --------------------------------QEAASIFKERFVPPELSIWDYFIAKPLL PPSENRIEYDSEDSQGSN-DEEE-D----DDD-----D-DYGDVFDPNSPQREHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTHLHDEAATPGPALLRHKALFEPTNTPFRSSHHSALPVKRLWQFLVKQEEVQ ETFIRNIFTKKPGT---------------------NQ-------------------TESD LGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAETKG-VGGDDFLVVHARDDFASLHGTTPYTHSSPGTPINVPWLGGLQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGNTPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHESGATVLSMAPRQQLL ITGGRKGWISVLELPHRHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLATQC ALYTFTNEHARQSLFRNLGTGVMQLEVGPANHIFSCGADGTMKMRILPNRF--------- ---SV--V-NNNH-----------GNLKNEVKFFI >ENSLCRP00005009063 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------KVNCQW QKTGQFVLKSMVRNLAWHPT---------------------------------------- ------------------------------------GST-LLTGSSSLQLWSN------- --------V-DGVKDE-------------------------------------------- -------------------------------------------AEEEVTQT--------- --------EMTIRDSH-SAWRC-----------IW------------------------- --ESKTASPVSLMKFSPDGEFFATAG---------------QDDCLVKVWYSTSKWKSSV SRLFTPPEHSVGVQGELAFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------VVCNVL LTCCKDSVCRLWAETLLPGDSLLSG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------NNHI----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----LSFQESLYTSFYRDGP---------------------------------------- ----------------------------------------------QPSLTGCLPHHQNR -HYNHKKS---SSSMP-HANALCHFHIAASINPATDIPLLPSISSLSAVDDEEPGGPFTV HWLNNKELHFTLAMEVFLQQLRGSLEH--------------------------------- ------------QNECSQE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------DEDNFDEEDNGSRPNDPQGPEAAE ---------------------------------------------------------LPL AAVKHQVDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQAQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQTK SALISYGGQGKA-----------AP--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEVDNILATP--CSS-GFSHST----------------------------- ------------------------------------------SLPRGSRPSRASLGAVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GAY CNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDTITG--------------------F------------ ------------------QGKETQLL---------------------------------- -------FNLQHLHHLQTDSY--------------------------------------- ------------------------------------------------------------ --------------------------------EP-------------------------- -------------AFSARFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAAQPV--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EDAMTEKGATPASSCNSSQFNFDTFS------------------SPVTP K-----------------SKPCTSNLQSACRLTLTTHRLYSQEMALPEGVEAISITPSAG HLSASCSLPAGRVPYLLATSCSDGKVRFWRCNVIVTK----------------------- ---PSNVDNLVYQWEEWPLLVEEMLPNSSVVSVPGRPIEVTCCHAGRIAVAY-------- ---------RQIPNL--------------------------------------------- ------------------------------------------------------------ ---------------------------ANTREPL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQIIVLD----------- ------------------------------------------------------------ ----GTDPTSN------------------------------------------------- --CDISSSTTGSASTPCNM----------------------------------------- ---------------------------DFS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---IPIENCLGSTTKNLVHLDWVSQENGSHVLTVGIGTKIYMYGCLSGKPPELCLSSDAS RDQS----SSRLVLLRSVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APPKPTVTIAQDTDISSSISSIISAVRQSQEEGLSPGVPLSSLA--------------- -----------------------------------P------------------------ -------------------PKRALTRSMMSLAQKLS---GKRTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVTLKDSSIT-------- ---NPEKRVRSRTIS---AGGSTARDRKMFSK-AENSTPDYTEISSIPPLPLYALLAAD- EDMSPKP------------------------G-----------------SGHGSR----- ------------------------------------------HSDAYDELFQ--TPSIAD --------------------LDPL-DNDQEETGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDSQGKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPTWPELRSMGVGWWLRSTDKLRRCIEKVARASLQRNNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCIE KMQDLQLALVISRLYESEFETASTYKKILRR------------HVLGQDKQVLS------ ---------------------LCMSQPSQA--------QDPFLRSMAHWVLEDYSRALDT LLEQ---------P--------------------G------------------------- -------------SSPV-----------------------------------------ST CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSD---KAKVG---- ------LTAEGRRADSISLEERRLFFTAAYTHLQAGCPMLALEVLSKMPKVRKHSKLTNQ EDTGIST----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSKNGQTS DPDWSQQTLNGYESNGN---SL---------SDSVLSFDWSQPSLTLPDESLELKWDSDK ND---EE-DD-EDEEE-TKNDKSG------------------------------------ ----------------------------------------------TT------------ ----------------------SE---------------GILPVLEHA------------ ---VSPLTEL-------------------------------------------------- ------------------------------------------------------------ ----VT-----------------------------------------------GEDSEDS DDF-------------------------------------IEPS---------------- --------------D--------------------------------------------- --------DILAAQLKFTACLKIMTNELRTLSTGYELDGGKLRYQLYQWLERE------- ---------------------V-------------------------------------- VALQRCCSYKPCL----------------PELSVQGDGPVSGLVEEEQVG---------- ------------------------------------------------------------ ------------PGS--------------------------------------------- ----------------PRGDN--------------------------------------- ---------------------------Q-----------------------------RS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESHQ-- -----------VTKTLTPCCQQ-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TSIPLLMACTANVKTVVANPIVYLTNLTHDILQTINALDSPPHPDIVNNEIYVLHTLA ASLSACIYQCL----CDGHTH-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQPVRTVSMDESVQPNTSPAQWPG--- -----IASLVRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIMAHP LNSKLWVTVFGGGARIPM--------------------QLKSKMLQHFLSMPT------- ---------------------------------------------ASPSGS--------- ------------------------------------------------------------ ERKSRRFRLLSSRSGSREDSGME------------------RESPSSPK---HCPVVE-- --------------------------------QEAASIFKERFIPPDLSIWDYFITKPLL PPSQSRIEYDSEESQGSQ-D--E-E----DED-----D-DYEDVFDPNSPQREHSSHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQVLQKRLEIFG GPPSQYISTHLQDESTAPGPALLRHKALFEPSNTPF--SHPSALPVKRLWQFLVKQDEVQ ETFIRHIFTKKRDPNESGEDQTDFMKCSGMEETGNHQ-------------------TESD LGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAETKG-VGGDDFLVIHARDDFAALHGTTPYTHSSPGTPINMPWLGGVQTGRGAS----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGNAPKPPFLHTVQCHNKTAHDFVFVGSSSLIATAGLSAD NRNVCLWDTLVTPANCLVH--------------------AFCCHESGATVLAMAPRQQLL ITGGRKGWISVLELCHRHQRQSFQAHDSPVKALAVDPTEDCFISGSSEGNIKVWSLATQC PLYTFPNEHARQSLFRNLGTGVMQIEVGPANHIFSCGADGTMKMRILPNRF--------- ---SV-VNNNNNH-----------GNLKNDVKFII >ENSGACP00000008245 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV CCVDCSLQGGK------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPVQPPDQK----------DTSLT-------------LNCQW QKTGQFLLKSMVRNLAWHPT---------------------------------------- ------------------------------------GST-LLTGSSSLQLWSN------- --------V-AGVRDE-------------------------------------------- -------------------------------------------AEEVETQA--------- --------EMTM-ESH-SAWRC-----------IW------------------------- --QSKMASQVSLMKFSPDGEFFATAG---------------QDDCLVKIWYNTSKWKLGV SKLFTPPEP--CGQGELAFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDGLLSG----------------------------------- -------------------------YH--------------------------------- ------------------------------------------------------------ ---------------------------------------NNHASGQHGATPGCAG----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------NTCNRKLHGS TAQELNFQESLHGSFYRDVL---------------------------------------- ----------------------------------------------QPSMTGCLPHNQSR -HDSHKRS---RSSMP-HANALCHFHIAASINPATDIPLLPSISSLSSVDDEEPGGPFTV HWLNNKELHFTLAMEVFMQQLRGSLEQ--------------------------------- ------------QDECSHE----------------------------------------- ------------------------------------EL---------------------- ------TRGHCDLR---------------------------------------------- ------------------------------------------------------------ ------------------------------SLPVPDEEDNFDEEDNNCRPGDSQAPEAAE ---------------------------------------------------------LPL AAVKHQVDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQAQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQAK SPLISYGGQGKA-----------AP--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVGFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSILAPPDAYSC-GFAHPA----------------------------- ------------------------------------------FIPRGSRPGRGTLGAVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFAQVAWLPTFIPSSCL--GVY CNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPQISK--------------------Y VGEVFNIISQQSTAKPGCIIELDTITD--------------------F------------ ------------------QGKETQLLHVFEEDLILG------------------------ --------------------------------------SE-------------------- ----------------------------------------------RMESTLPTPDPLHT --------------------AS---------SQA-------------------------- -------------AFSARFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAARPI--------T---------- --------MGE----------------H--FTTKEMDATLASSM---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------NSSTFSFDTFS------------------SPAAQ K-----------------SKPCTSNLQSACRLSLTTHRLYSHEMALPEGVEAISVTPSAG HLSASCSLPVDRVPYLLATSCSDGKVRFWRCNVIATD----------------------- ---PFSMDSLVYHWEEWPLLVEENLPNCSAVSVQGRPIQVSCCHSGRIA----------- ------------------------------------------------------------ ----------------------------------------RSP----------------- -------------------NLPPSPKAANLREPL-----------------------VH- --------------------------IGIFQCESTGGSQWHLEQTIVLD----------- ------------------------------------------------------------ ----SADPT--------------------------------------------------- ------------------------------------------------------------ -----------------IASASIPGNVDIP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---VTNEDCLGSTRKSLVHLDWVSQEDGSHVLTVGIGTKIYMYGRLSGKPPELGLMSDAS REQS----SSRMVLIRSVNLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APSRPNAPIAQDTDISSSLSSIISAIRQSQEDP-SSGAAMSSLA--------------- -----------------------------------P------------------------ -------------------PKRALTRSMMSLAQKLS---GKRTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVALKDST-T-------- ---SHEKRVRSRTIS---AGGSTARDRKMFTK-AENSIPDYTEISSIPPLPLYALLAAD- EDTSPKP-------------------GWYTTY-----------------SGHGSS----- ------------------------------------------HTDVYDELFH--TPTIGD --------------------LDPL-HDDQEETGN-------------------------- --------------------------------------KVIDLSQYSPTFFGAEHAQVLS SHLLNSSLPGLTRMEQMSLMALADTIATTSTDLKDSQGKSKGGETLDECGLKFLLAVRLH TFLSTSVPPAHRAQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPTWPELRSMGVGWWLRSTNKLRRCMEKVAKTSLQKNNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDA--VCIE KMQDLQLALVISRLYESEFETTSTYKKILQR------------HVLGQDKQVGNVY---V V-------------------ILCIFQ--------IQAHQDPFLRSMAHWVLEDYSRALDT LLEH---------PAN-----STRSASTGTK----------------------------- ------------------------------------------------------------ -------------------------VFNFYTYLRTHPLLLRRHFGSSD---KAKVG---- ------LTAEGRRADSISLEERTLFFTAAYSHLQAGCPMLALEVLSKMPKVRKHSELPNQ GDAGAAA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSKNGETS NQGWSQQTLNGYESDGN---CLS-----NSRSDSVLSFDWSQQSITHADEPLELKWDSDK D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------GED--------------DVDEEETKNVDSSHVFQNP------------ EDATSPLAE------------------------------------VLM------------ -----------------------------------------------------GEVREDC NDF-------------------------------------LPPS---------------- --------------N--------------------------------------------- --------DILAAQLKFTACLKIMTNELRTLSTGYELDGGKLRCQLYQWLERE------- ---------------------V-------------------------------------- VALQRCCSYKPCL----------------PELSFQGDAPVSGLVEDER------------ ------------------------------------------------------------ ------------PGS--------------------------------------------- ----------------PHGDS--------------------------------------- ---------------------------Q-----------------------------RS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSTQPVV- PCGQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTSNVKTVVANPLVYLTNLAHDILKTINSFDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDGHTH-------------------------------------S- --HVNQFTGIVYQ--------------SVLLSLKQPLRTVSMDESVQPNTSPAQWPG--- -----IASLIRLLS-SAGEESQPGLTVLLCEILTAVFLSLFVHGMATHSSNELFRIGAHP LNGKLWVAVFGGGARTP------------------------------------VIGKPNS PTKTPP------P--------------------------------ASPSGS--------- ------------------------------------------------------------ DRKSRRFRFLSSRSGSREESGIN------------------H--PSSPK---HGPVVE-- --------------------------------QEAASIFKERFVPPELSIWDYFIAKPLL PPSEDRIEYDSEESQGSQ-D--E-E----EDD-----N-EYEDVFDPSSPQREHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTPLQDETAAPGPALLRHKALFEPSNTPFRTSHHSALPVKRLWQFLVKQEEVQ ETFIRNIFTKKRGL---------------------NE-------------------TESN LGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- DAEVKG-VTSDDFLVVHARDDFAALHGTTPYTHSSPGTPINMPWLGGVQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGNAPKPYL--TLQCHNKTAHDFVFVGSSSLIASAGLSTD NRNVCLWDTLVTPANCLVH--------------------AFCCHESGATVLSMASRQQLL ITGGRKGWISVLELAHKHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKIWSLATQC ALYTFPNEHARQSLFRNLGTGVMQIEVGPTNHIFSCGADGTMKMRVLPNRF--------- ---SI--I-NNNN-----------NDLKNDVKFII >ENSSMAP00000007869 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSVQGGQVRV------REWYSFLFGPQVDLVCVPDIPYS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ST-LLTGSSCLQLWSH------- --------V-DGVKYE-------------------------------------------- -------------------------------------------AEERGKQS--------- --------EMTMRDSH-C------------------------------------------ ------------------------------------------DDCLVKVWYSTSKWKLGV SRLFTPPEPSVSIQGELAFSFVYLAHPRSVTGFSWRKTSTYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLSG----------------------------------- -------------------------FH--------------------------------- ------------------------------------------------------------ ---------------------------------------NNH------------------ M----------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------REKKSKGRM------- -------------------------------------GKEMEIKLRRED----------- ------------------------------------------------------------ -----------------------------------------------PSLTGCLSHHQSR -HFNHRKS---SGNIP-HANALCHFHIAASINPATDIPLLPSISSLSAADDEEPGGPFTV HWLNNKELHFTLAMEVFLQQVRGNLEQ--------------------------------- ------------QNECSHE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------DEDNFEEEDNGSRPKDPQRPEGTG ---------------------------------------------------------LPL AAVEHQVDVLLEEWNKGADMLFSIHPMDGSLLVWNVDWLDEYQPGMFRQAQVSFVSRIPV AFPAGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSSLPQTK SALISYRDQGKA-----------TA--------------------------SNSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSSFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPDVDSILAPPEV--------ST----------------------------- ------------------------------------------SVPRGSRASRVSLGVVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNMISQQSTAKPGCIIELDAITD--------------------F------------ ------------------VRKETQLLHVFEEDLILG------------------------ --------------------------------------SE-------------------- ----------------------------------------------RTESTQDTADSP-- --WA---------------------------GEP-------------------------- -------------TFSARFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAARPI--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------DKDATRASPMNSSQFDFDTFT------------------SPVTQ K-----------------TRTCTSSLQSACRLSLETHRLYSQEMALPEGVEAISVTPSAG HLSASCSLPAGRVPYLLATSCSDGKVRFWRCNVVATG----------------------- ---SSSTDTLLYQWEEWPLLVEERFPSSSSVSVPGRPVEVSCCHTGRIAVAY-------- ---------RQ------------------------------------------------- ------------------------------------------------------------ -----------------------TPNLANISEPL-----------------------VH- --------------------------IDIFQCESTGGSQWIPEQTIVLD----------- ------------------------------------------------------------ ----GTDPTSN------------------------------------------------- --SGT------------------------------------------------------- -----------------------------T------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---LPNENCLGSTSKSLVHLDWVSQEDGSHVLTVGIGTKIYMYGRLSGKPPELGLSSDAT REQS----LSRLVLLRSVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -TPPRPSAVIAQDTDISSSVSSIISAVRQSQEEGLSAGAPASLLA--------------- -----------------------------------P------------------------ -------------------PKKTLTRSMMSLAQKLS---GKRTA-YDLPVELEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVPLKDST-T-------- ---IPERRVRSRTIG---AGGSTARDPKIFDI-AENSTPDYTEISSIPPLPLYALLAAD- EDTSPNP-------------------GSVSGD-----------------SRHGST----- ------------------------------------------HTDAYDELFH--TSSIVD --------------------LDPL-DNNQEETGN-------------------------- --------------------------------------KVIDLSQYSPTYFGAEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKGSQGKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPNWPELRSMGVGWWLRSTNKLRRCIEKVAKVSFQRSNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTDFFRNNFSEDRWRKAALKNAFSLLGKQRFQHAAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETASTYKKILQR------------HVLGQDRQV-------- -----------------------------HRG-FISAHPDPFLRSMAHWVLEDYSGALDT LLEQ---------PTN-----SNS------------------------------------ -------------SSSV-----------------------------------------ST CNP---------------------EVFNFYTYLRTHPLLLRRHFGSSD---KAKVG---- ------LTAEGRRADSVSLDERRLFFTAAYAHLQAGCPMLALVILSKMPKVHKHSKVPNQ EDTGISG----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSAGSKDGQAS --DWSQPSLNGYESDGN---SLS-----VSKSDSVLSFDWSQPSVTLPDEHLELKWDSDK DE---EE-ED-EDEEE-IKNPKTGRIADSSS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDTQDVMSP LM---------------------------------------------------GEDSEDS NDF-------------------------------------IAPS---------------- --------------D--------------------------------------------- --------DILVAQLKFTACLKIMTNELRTLSTGYEVDGGKLRYQLYQWLERE------- ---------------------V-------------------------------------- VALQRCCSYKPCL----------------PELSVLGD----------------------- ------------------------------------------------------------ ------------PGS--------------------------------------------- ----------------PRGDS--------------------------------------- ---------------------------Q-----------------------------RS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESHQL- --------LSPL------------------------------------------------ ------------------------------------------------------------ -CSQ-------------------------------------------------------- ------------------------------------------------------------ -PTLIPLLMACTANVKTVVANPIVYLTNLTHDILQTINALDSPPHPDVINNEIYVMHTLA ASLSACIYQCL----CDGHTYRYCCLFPHLFLPAL------------------PFSSRS- -------------------------------------------------------PG--- -----IASLIRLLS-SAGEESQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIMAHP LNSQLWVTVFGGGARTP------------------------------------VIEKPNS PTRTPPLGDCFS------------------------------------------------ ------------------------------------------------------------ ----------------------E------------------REGPSSPK---HVPVVE-- --------------------------------QEAASIFKERFVPPELSIWDYFIAKPFL PPSENRIEYDSEESQGSQ-D--E-D----EDE-----Y-EYEDVFDPNSPRREHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTHSQDETAAPGPALLRHKALFEPSNTPFRTNHHSALPVKRLWQFLVKQEEVQ ETFIRNIFTKIRDPNE----------------------------------------TGSD LGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQIMTWIDDD- EAEAKG-AAGDDFLVIHARDDFAALHGTTPYTHSSPGTPINMPWLGGVQTGRGAA----M MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGNAPKPFL--TLHCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHESGATVLAMAPRQQLL ITGGRKGWISVLELPHKHQRQSFQAHDSPVKALAVDVIEDCFISGSAEGNIKVWSLATQC VLFAFPNEHARQSLFRNLGTGVMQIEVGPTNHIFSCGADGTMKMRVLPNRF--------- ---SVGGNNNNNH-----------GNLKNDVKYII >ENSPRNP00000040178 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCIFEPVKNPDLK----------ETSLT-------------WNCQW QKTGQFVLQSMVRNLAWHPT---------------------------------------- ------------------------------------GST-LLTGSSSLQLWSND------ GEKGEEEG---------------------------------------------------- ------------------------------------------------KQT--------- --------EMNMRDSR-SAWRC-----------IW------------------------- --QSKTASPVNLMKFSPDGEFFATAG---------------QDDCLVKVWYSTSKWKSSV SRLFTPPEPTVSVQGDLTFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLFG----------------------------------- -------------------------HY--------------------------------- ------------------------------------------------------------ ---------------------------------------NNH------------------ MFG-------------QYNEALKCA----------------------------------- -------------------TP---------------SKKNVTSQKEKP-------VH--- -------------------------------------HAKQLNTK--------------- ------------------------------------------------------------ ---------SWHSSFYRDIP---------------------------------------- ----------------------------------------------QPSLTGGLPHHQSR -HCNHKKS---STSMP-HANALCHFHIAASINPATDIPLLPSISSLSAVDDDEPGSLFTV HWLNNKELHFTLAMEVFL--LRGSLQQ--------------------------------- ------------QNECS------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------NEDDFDEEDNSGRPSDPQGAEAVK ---------------------------------------------------------LPT AAVEHQVDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQAQVSFVSRIPV AFPAGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPT-------------GSTLPQAK SALISYGGQGKA-----------AP--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSIL-------------------------------------------- ------------------------------------------------------------ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGRSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEDLILG------------------------ --------------------------------------IE-------------------- ----------------------------------------------RTESTQETPDSPHS --------------------AS---------SEP-------------------------- -------------AFSARFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLA----------------------- ---------------------------------------------------SISEQYSSL A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q K-----------------NKSCTSNLQSACRLSLTTHRLYSQEMALPAGVEAISVTPSAG HLSASCSLPAGRVPYLLATSCSDGKVRFWRCNVVTTE----------------------- ---PSSMDNLVYQWEEWPLLVEERLPNSSAVSVPGRPVEVSCCHTGRIAVAYNPNLA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------KEPL-----------------------VH- --------------------------IGIYQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----TTEATAN------------------------------------------------- --CGISSNMIGSADIPNNT----------------------------------------- ---------------------------DFS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---IPNENCLGSTSKSLVHLDWVSQEDGSHVLTVGIGTKIYMYGCLAGKPPELGLSSDVS RDQS----LSRLVLLRSVNLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -LPPKPNVTITHDTDISSSVSSIVSAVRQCQEECVFLGAPTSLLA--------------- -----------------------------------P------------------------ -------------------PKKALTRSMMSLAQKLS---GKRTA-YDLPVEMEDSGLFEA SHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVALKDSN-A-------- ---NPEKRLRSRTIS---AGGSTATDRKMFSK-AENATTDYTEISSIPPLPLYALLAAD- EDT-PKT-----EKV-----------GSVSAD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPNIVD --------------------HDPL-DTDQEEAGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDSQGKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPSLQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTDFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETASTYKKILQR------------HVLGQDKR----HSNMN ----------------------------------IPAHQDPFLRSIACWVLEDYSRALDT LIEQ---------PAN-----R-------------------------------------- -------------SSSV-----------------------------------------ST CNP---------------------EVFNFYIYLRTHPLLLRRHFGSSD---KAKVG---- ------LTAEGRRADSISLEERRLFFTTAYAHLHAGCPMLALEVLSKMPKVHKHSKLLSQ EDTGIAG----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSRNEPTS DPDWSQPALNGYESDGN---SLS-----NSQSDSVLSFDWSQPSLTLPDEPLELKWDSDK DD---ED-ND-DNEEE-TKNDKSGRTADSSS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDTQDAIST QMETVT--------------------------------------------------EEDG NDF-------------------------------------IAPS---------------- --------------D--------------------------------------------- --------DILVAQLKFTACLKIMTSELRTLSTGYELDGGKLRYQLYQWLERE------- ---------------------V-------------------------------------- VALQHCCSYKPCL----------------PELSVQGDVPVSGLVEEEQ------------ ------------------------------------------------------------ ------------VGV--------------------------------------------- --------------------S--------------------------------------- ---------------------------Q-----------------------------RR- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESHQVI ---FFPSQL--------------------------------------------------- ----------------------------------------------------------VT SASQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTANVKTVVANPIVYLTNLTHDILQTINALDSPPHPDVVNNEIYVLHTLA ASLSACIYQCL----CDGHTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSEKQTVRTVSLDESVQPNTSPAQWPG--- -----IASLIRQLS-SAGEDSQPGLVVLLCEILTAVFLSLFVHGMATHSCNELFRIVAHP LNSTLWVTVFGGGARTP------------------------------------VIEKPSS PTRTPP------PGD----------WFGMCVFLSDSEVFFLEVTQY-------------- ------------------------------------------------------------ -----------------------------------------------PR---HFPVVE-- --------------------------------QETPSVFKERFVPPELSVWDYFIAKPSQ PPSENRIEYDSEESQGSQ-D--E-D----DDD-----DGEYEDVFDPNSPQREHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTYLQDETATPGPALLRHKALFEPSNTPF--SHQSALPVKRLWQFLVKQEEVQ ETFIRHIFTKKPGSNQSVEDQTDNMKYSGMDETGSNQ-------------------TESE LGCPGGKARIIHKESDIITAFAINKANRNCLAMASTHDIQELDVSSILATQILTWIDED- ETEAKG-VGGDDFLVVHARDDFVTLHGTTPYTHSTPGTPINVPWLGAMQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGNTPKPYL--TLHCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHESGATVLSMAPRQQLL ITGGRKGWISVLELPHRHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLSTQC LIHTFPNEHARQSLFRNLGTGVMQIEVGPANHIFSCGADGTMKMRVLPDRF--------- ---SV--TNNNNH-----------GNLKSDVKFII >ENSMALP00000027066 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------IKFSPDGEFFATAG---------------QDDCLVKLWYCTSKWKSGV SGLFTHPETTDSVQRELAFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSVLSD----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------NNPASGQHSDTHRCTGP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PSLSRCLPDHHSG -HYGHKKS---TNNMP-HAIALCHFHIAASINPATDIPLLPSISSLSAVDDEEPGGLFTV HWLNNKELHFTLAMEVFLKQLQGNLEQ--------------------------------- ------------QNEGSHEG--------------------------------------TE EYLD----IVYTI----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------RPSDTQGPQAVE ---------------------------------------------------------LPL AAVEHQVDVLLEEWNKGADMLFSIHPMDGSLLVWNLDWLDEYQPGMFRQAQVSFVSRIPV AFPAGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQTK SALISYRGQGKA-----------AA--------------------------SSSLRLSIF TPNVLMISKHADGTLNQWAVSFAEDSAFSTVLSISHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEVDSILAHPEAHSS-AFSRLK----------------------------- ------------------------------------------SLPPGSRPSRMSLGGVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GAY CNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPEMSK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------VRKETQLLHVFEENLILG------------------------ --------------------------------------SD-------------------- ----------------------------------------------RTESKPESPDSPHT --------------------AA--------FSRP-------------------------- -------------AFSARFFLVVVELSPTGRSLLHMW----------------------- --------------------------------HLHLAARHV--------T---------- --------I--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------EKDATTASPVNSPQFNFGMFG------------------SSVTQ K-----------------SKPCTSNLQSACRLSLTTHSLYSQEMALPEGVEAISVTPSAG HLSASCSLPADRLPYLLATSCSDGKVRFWRCNVMAAE----------------------- ---PPTMDSLVYRWEEWPLLVEERLPNSSAVSVPGRPIEVSCCHTGRIAVAY-------- ---------RQMPNT--------------------------------------------- ------------------------------------------------------------ -------------------------------SPL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQIIVLD----------- ------------------------------------------------------------ ----STDPTAN------------------------------------------------- --YDISSGAIGSASVQSNM----------------------------------------- ---------------------------DLS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---LPNDNCLGSTCKSLVHLDWVSQEDGSHVLTVSLGTKIYMYGRLSGKPPELGLSSDAS RDQS----LSRLVLLRSVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APPKPNVAIAQDTDISSSVSSIISAVRQSQEEGLNPGLSTSSLA--------------- -----------------------------------P------------------------ -------------------PKKVLTRSMMSLAQKLS---GKRTV-YDLPVEMEDSGLFEA AHQLFTTLPQYHPVQLLELMDLGKVRRAKAILSHLVKCIAGEIVALRDNT-A-------- ---NPEKRVRSRTIS---AGGSTARDPKVFSK-AESSTSDYTEISSVPPLPLYALLAAD- EDTSPKP-------L-----------GSVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPSTVD --------------------LDPL-DSDQEETGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLA SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDSQGKSKGGETLDDCGLKFLLAVRLH TFLSTSLPPAHRAQLLQQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPTWPELRSMGVGWWLRSINKLRRCIEKVAKASFQKTNDPLDAAIFYLAMKKKAVVWGLY RSQKNAKMTAFFHNNFSEDRWRKAALKNAFSLLGKRRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEYETASTYKKILQR------------RVLGQDKQV-------- -----------------------------PRVLYIPAHRDPFLRSMAHWVLEDYSRALDT LLEQ---------PAN--------------------NARDEN------TDFQKIEA---- ---------GSS------------------------------------------------ -------------------------VFNFYTYLRTHPLLLRRHFGSSD---KAKVG---- ------LTTESRRHDSISLEERRLFFTAAYAHLQARCPMLALEVLSKMPKVRKHSKLSYQ EDRNITA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGNQNGQAS DPDWSQPALNGYESDGN---SLS-----ISRSESVLSFDWSQPPLTLPDEPLELKWD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------KTKNA--------------------- ------------------------------------------------------------ -----------------------------------------------------KKDSEDS NDF-------------------------------------ITPS---------------- --------------D--------------------------------------------- --------DILAAQLKFTACLKIMTNELRTLSTGYELDGGKLRYQLYQWLERE------- ---------------------V-------------------------------------- VALQHCCSYKPCL----------------PELSVQGD----------------------- ------------------------------------------------------------ ------------SGS--------------------------------------------- ----------------PHGDS--------------------------------------- ---------------------------Q-----------------------------RN- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ------------------------------------------------------------ -------------------------------------------------------QSVVT SSSQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTANVKTVVANPIVHLTNLTHDILQTINALDSPPHPDVINNEIYVMHTLA ASLSACIYQCL----CDGHTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQSLRTASMDESLQPNTSPVQWPG--- -----IASLIHLLS-SPGEECQPGLIVLLCEILTAVFLSLFVHGMATHSSNELFRIVAHP LNSKLWVKVFGGGVQTP------------------------------------VTEKPMS PTRSPS------P----------------------------------------------- ------------------------------------------------------------ -----------------EESGIE------------------PEGCSSPK---HAPVVE-- --------------------------------QGATSTFKERFVPPELSIWDYFIAKPLL PSSENRIEYDSEESQDSQ-D--E-------DD-----D-EFEDVFDPHSPKREHLNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQVLQKRLEIFR GPPQKYISTHLQDEATAPGPALLRHKALFEQSNTPF--SHHSALPVKRLWQFLVKQEEVQ ETFIRNIFTKKPDL---------------------NE-------------------TESD LACPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAETKG-VGGDDFLVVHTHNDFAALHGTTPYTHSSPGTPINMPWLGGMQTGRGAS----V MIKRNINNVRRMASHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFSHQ GNKFGIIDADGGLSLWQTNTSGNAPKPYL--TLQCHNKTAYDFVFVSSSTLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHESGATVLAVASRQQLL ITGGKKGLISILELAHRRQRQSFQAHDSPIKALAIDPTEDCFISGSAEGNIKVWSLATQS LLYTFPNEHARQSLFRNLGTGVMQIEMGPASHIFSCGADGTMKMRILPNRF--------- ---ST--V-NNNS----------DGNLKNDVKFFI >ENSMAMP00000028257 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MKFSPDGEFFATAG---------------QDDCLVKVWYSTSKWKSGV SELFTPPEPSVSVQRELAFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSILSG----------------------------------- -------------------------YH--------------------------------- ------------------------------------------------------------ ---------------------------------------NNPAFGQYSDTLRC------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----LNFQESWH-SFYRDMP---------------------------------------- ----------------------------------------------QPSVTGCLPHHQSG -HYSHKKS---SNSMP-HANALCHFHIAASINPATDIPLLPSVSPLSVADDEDPGGPFTV HWLNNKELQFTLSMEVFLQQLRDNLEL--------------------------------- ------------QNEGLNE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------DNENFDEDDNDSRPSDPQGPEAVE ---------------------------------------------------------LPL AAVEHQVDVLIEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQTQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGKQ----RPP-------------GSTLPQTK SALISYGGQGRA-----------AT--------------------------SSSLRLSIY TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEVDSILATPEACSI-GFAH------------------------------- ---------------------------------------------------RVSLGMVSQ DPNAVYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGHSLRLYQAVIEAKTLLSELSNPEISK--------------------Y VGSVFNIISQQSTAKPGCIIELEAITD--------------------F------------ ------------------QGKEAQLLHVFEEDLILG------------------------ --------------------------------------RE-------------------- ----------------------------------------------RRDNTRETP----- ------------------------------------------------------------ --------------FSARFFLVVVELTPTGRSVLHMW----------------------- --------------------------------HLHLAARP------ET-T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------EKDAT--------------------------------------- ------------------SKSSTSNLQSACRLSLTTHRLYSQEMALPEGVEAISVTPSAG HLSASCSLPVDRVPYLLATSCSDGKVRFWRCNVVPAE----------------------- ---PSSINNLVYQWEEWPLLVEEKLPSSSAVSVPGRPIVVSCCHTGRIAVAY-------- ---------RQT------------------------------------------------ -------------------------------------------------AE--------- ----------------------------NIREPL-----------------------LH- --------------------------IGIFQCESTGGSQWILEQIIVLD----------- ------------------------------------------------------------ ----NADPTAN------------------------------------------------- --YGICSSAAGSANIPSNM----------------------------------------- ---------------------------DFS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---LPNENCLGSTSKSLVHLDWVSQEDGSHVLTVGIGTKIYIYGRLAGKPPDLGLHSDAS RDQR----LARLVLLRSVNLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -PAAKPNPTIAQDTDISSSVSSIIAAVRQSQEEGLSPGAPMSSWP--------------- -----------------------------------P------------------------ -------------------PKKAMTRSMMSLAQKLS---GKRTA-FDLPVEMEDFGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVALKDST-S-------- ---NPEKRVRSRTIS---AGGSTARDLKMFGK-AETSIPDYTEINSIPPLPLYALLAAD- EDTSSNP----------------------------------------------------- -------GEY---------TLTQFSRQRNILIFKEY---------AYDELFH--TPSIVD --------------------PDPL-ENDQEETGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAHVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDSQGKSRGGETLDECGLKFLLAVRLH TFLSTSMPPAHRAQLLRQG-------------LSTCHYAWAFHSESDEELLNMLPALQKG EPTWPELRSMGVGWWLRSTDKLRRCIEKVAKACFQRTNDPLDAAIFYLALKKKAVVWGLY RSQKNVKMTEFFHNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETASTYKKILQR------------HVLGQDKQV-------- -----------------------------ER---IPAHQDPFLRSMAYWVLEDYSRALDT LLEQ---------P---------------------------------------------- ------------------------------------------------------------ --PKYPRSGSK------------CDVFNFYTYLRTHPLLLRRHFGSSD---KAKVG---- ------LTAEVRRADSISLEERRLFFTAAYAHLQAGCPMVALEVLSKMPKVHKCSKHSSQ EGIGITA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSVNGQAS DPDWSQPALNGYESDGN---SLS-----NSQSDSVLSFDWSQPSLTHPDEPLELKWDSDK DD---ED-ND---DEE-PKNVKSSRTADNTS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDTQDAMSP LMETVT-----------------------------------------------GEASEGS SDF-------------------------------------IAPS---------------- --------------D--------------------------------------------- --------DILAAQLKFTACLKIMTNELRTLSTGYELDGGKLRYQLYQWLERE------- ---------------------VI------------------------------------M VALQHCCSYK-------------------PELSVQGDNPVSGLADEEQV----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ GVDSWLFQDLRHWLQSN----QPLLRMFLSYCGLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSIQSVVT LSSQ-------------------------------------------------------- ------------------------------------------------------------ -TNSVPLLMACTTNIKTVVANPIVYLTNLTHDILQTINALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDAHTY-------------------------------------R- --HVNHFTGIVYQ--------------SVLLSQKQPVRTVSMDESVQPNTSPAQWPG--- -----ITSLIRLLS-SAGEESQPGLTVLLCEILTAVFLSLFVHGMANHSSNELFRILAHP LNSKLWVTVFGGGARTP------------------------------------VIEKHST ----------------------------------------------SPSGS--------- ------------------------------------------------------------ DRKSRRFRLLSSRSGSREESGLE------------------REGPCSPK---HGPVVE-- --------------------------------QEATSVFKERFIPPELSIWDYFIAKPLL PPSQDGIEYDSEESQESQ-D--E-D----DDD-----D-EYEDVFDTNSPQREHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKFISTHLQDETATPGPALLRHKVLFEPSNTPF--SHHSALPVKRLWQFLIKQEEVQ DTFIRNIFTKKPDP---------------------NE-------------------TESD LGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAEVKG-VGSDDFLVVHARDDFAALHGTTPYTHSSPGTPINMPWLGSLQTGRGAS----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNK----------------------------TLQCHNKTAHDFVFVSSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHESGATVLSMAPRQQLL ITGGRKGWIGILELSHRHQRHSFQAHDSPVKALAVDPTEDCFISGSAEGNIKIWSLATQS LLYTFPNEHARQSLFRNLGTGVMQIEVVPPNHIFSCGADGTMKLRILPNRF--------- ---SV-VSNNNNY-----------DNLKNDVKFFI >ENSBSLP00000008039 MNLHQVLTGAVNPGDNCFSVGSFNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLRGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPVQHPDQK----------DKS----------------RCQW QKTGQFVLQSMVCNLAWHPT---------------------------------------- ------------------------------------GTT-LLTGSSSLQLWSD------- --------A-DGGKDEYLVLNEFNFS---------------------------------- -----------------------------------------SCS---------------- ------------------------------------------------------------ -----TASPVNLMKFSPDGEFFATAG---------------QDDCLVKVWYSTSKWKSSV CKLFTPPEPSVIVQGELAFSFVYLAHPRSVTGLSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLYG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------DNYSSDQHSDSNRC------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----LNFQELQHYSSYRDVP---------------------------------------- ----------------------------------------------QPSLTGFLPHLQNH PHFSHKRS---STNTP-HANALCHFHIAASINPATDIPLLPSISSLSAADDEETGSLFTV HWLNNKELHFTLAMEVFLQQLRGSLEQ--------------------------------- ------------QNEGSNE--ADKATVDSDDNVDEEVNGSKASDPQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E ---------------------------------------------------------LPL AAVGHQVDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQTQVSFVSRIPV AFPAGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GTTLPRTK SALISYGGQGKA-----------AP--------------------------SSSLRLSIF TPNVLMISKHDDGSLNQWAVSFAEDSAFSTVLSVSHKSRFCGHRFHLNDLACHSVLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEVDSILAPPEACSS-GFSQSA----------------------------- ------------------------------------------SMSRRSRASRVSLGTVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPCSCL--GAY CNSPSACFVASDGHSLRLYQVVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEELILG------------------------ --------------------------------------T--------------------- ------------------------------------------------------------ ---------------------S---------GEP-------------------------- -------------PFSARFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLVAQPI--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------EKDATAASPLDGSQFNFDTYS------------------SPVIQ K-----------------NKPCTSNLQSACRLSLTTHSLFSQEMALPEGVEAISVTPSAG HLSASCSLPSDRVPYLLATSCSDGKVRFWRCNVMATE----------------------- ---SLSMENRAYQWEEWPLLLEEGLPNSSAVSVPGRPIEVSCCHTGRIAVAY-------- ---------RQTPNS--------------------------------------------- ------------------------------------------------------------ --------------------------AANTKAPL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----GTDPSADY------------------------------------------------ --------------------DVSSSSGESTD----------------ITI---------- ---------------------------DFS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---LPNDNCVGSNSKSLVHLDWVSQEDGSHVLTVGIGTKIYMYGRLSGKPPELGLSSDAG RDQS----LLRLVLLRSVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APPKPNVIISQETDISSSVSSIISAVRQSQEEVFNSAVPMSSLA--------------- -----------------------------------P------------------------ -------------------PRKALTRSMMSLAQKLS---GKRTA-YDLPVEKEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVALKDSA-A-------- ---NPGKRFRSRTIS---AGGSTARDPKMFSK-SESSTPDYTEISSIPPLPLYALLAAD- EDTSPAP-------------------GGVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFH--TPSIVD --------------------VDPL-DSDKEETGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDNQDKSKGGETLDECGLKFLLAVRLH TFLSTSMPPAHRAQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKVSFQKSNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFHNNFTEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE NLQDLQLALVITRLYESEFETASTYKKILQR------------HVLGQDKQV-------- -----------------------------H------INEDPFLRSMAYWVLEDYSRALDT LLEQ---------PKN-----MTT------------------------------------ -------------SSFV-----------------------------------------SR SNP---------------------EVFNFYIYLRTHPLLLRRHFSSSE---KAKVG---- ------LTTECRRASSISLEERRLFFTAAHAHLQAGCPMLALEVLSKMPKVHKHSKL--- --------S--------------------------------------------------- ------------------------------------------------------------ --------------------------------------KTQNASMATD-LSVGSKNEQSS DPDWSQTALNGYDSDRN---SLS-----NSQSDSVLSFDWSQPSVTLPDEPLELKWDSDK DD---ED-KDDEDDEGETKNAKSDITADSTS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDTQDAASP LMETVT-----------------------------------------------EEDSGES KDF-------------------------------------IAPS---------------- --------------D--------------------------------------------- --------DILAAQLKFTACLKIMTNELRTLSTGYELDGGKLRYQLYQWLERE------- ---------------------V-------------------------------------- -------------------------------------------------N---------- -----AVTYSTYTFSDASVRILMYILLY-------------------------------- EANKVQMVF--QPGS--------------------------------------------- ----------------PRGDS--------------------------------------- ---------------------------Q-----------------------------KS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELTLLLQESHQVI KTSL-------------------------------------------------------- -----------------------------------------------------------T SSHQ-------------------------------------------------------- ------------------------------------------------------------ -PASIPLLMACTANVKTVVANPIVYLTNLTHDILQTINALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDGQTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQPVRTVSMDESVQANTSPAHWPG--- -----ISTLISQLS-SAGEDSQPGLTVLLCEILTAVFLSLFVHGMATHSCNELFRIVAHP LNSKLWVAVFGGGAMIP------------------------------------VIEKPNT ----------------------------------------------SPSGS--------- ------------------------------------------------------------ DRKSRRFRLLSSRSGSKEESGMEPQSLYSPRRDR---------------------TVE-- --------------------------------QEAATIYKERFVPPELSIWDYFIAKPSL PQSENGVEYDSEESHSSQ-D--E-D----DDE-----D-GYEDVFDPNSPQKEHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQVLQKRLELFE GPPSKYISNHLQDETTTPGPALLRHKAMFEPSNTPFRSNHHSALPVKRLWRFLVKQEDVQ ETFIRNIFTKKRSP---------------------NE-------------------TESN LGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQIMTWVDDD- ETESKS-VGGEDFLVVYTRDDFAALHGTTPYTHSSPGTPINMPWLGGVQTGRGAS----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGVVDADGCLSLWQTNSSGNAPKPYL--TLQCHNKTAHDFVFVSSSSLVATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFYCHDSGATVLSVAPRQQLL ITGGRKGWISVLELSHKHQRQNFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSVASQA LLFTFPNEHARQSLFRNLGTGVMQLEVGPANHMFSCGADGTMKMRILPNRF--------- ---SVVSNNNNNY-----------GNMKNDVKFII >ENSLBEP00000022473 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------AFSFIYLGHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLLSG----------------------------------- -------------------------HN--------------------------------- ------------------------------------------------------------ ---------------------------------------NNHAS-QRSDSRRCADPSRK- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------NTCNGKMQGR TTQELNFQDSLQASLFRDVP---------------------------------------- ----------------------------------------------VPSLTGCLP-HQSR -HYKHKRV---SSHMP-HANALCHFHIAASINPATDIPLLPSISSLSGVDDEEAGGPFTV HWLNNKELHFTLAMEVFLQQVRGSMEQ--------------------------------- ------------QSEGSNE----------------------------------------- ------------------------------------E----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PEDEDNFDEEDHGSRPDDDQGPDAME ---------------------------------------------------------LPL AAVKHQVDVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQTQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSTLPQAK SALISYGGQGKA-----------AP--------------------------GSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSVLPLLL TTSHHN-------------------------ALK-------------------------- --------TPDVDSILAAPEACPS-GFPHST----------------------------- ------------------------------------------SLPHQSRSSRGSLGVVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GAY CNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITG--------------------F------------ ------------------QGKETQLLHVFEEDLILG------------------------ --------------------------------------SE-------------------- ----------------------------------------------RTESKWETPDLPNT --------------------GS---------CEP-------------------------- -------------AFSARFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLYIAALPV--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------DETSSATNATPASPLNSSRFSYDMFT------------------SPVAQ K-----------------SKPCTSNLQSACRLSLTTHKLYSKEMALPEGVEAIRVTPSAG HLSASCSLPAGRVPYLLATSCSDGTVRFWRCNVSSPK----------------------- ---PSGVKDLVYQWEEWPLLVEEGLPNSSAVSVHGRPVEVSCCHTGQIAVAY-------- ---------RQTPNT------------------------PLSSTPYLNSHALLTS----- ---PPSLSSTPYLHY----NNNTHL--------TPTLTVQRSP----------------- -------------------NLTPCPNPAKAREPS-----------------------FH- --------------------------ITIFQCESTAGSQWILDQTIVLD----------- ------------------------------------------------------------ ----STD------------------------------------------GMSSSISNTDF S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----NENCPGSSNKSLVHLDWVSQENGSHVLTVGIGTKIYMYGRLSGKPPELGLSSDAS RDQR----SSRLVLLRSVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -TPPKPNTTTGQDTDISSSVSSIISAVRQSQEDAFSNGAPMSLLA--------------- -----------------------------------P------------------------ -------------------PKKALTRSMMSLAQKLS---GKRTA-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVYRAKAILSHLVKCIAGEIVTLKDST-A-------- ---NPEKRVRSRTIS---AGGSTARDRKMFNK-AGNSTPDYTEISSIPPLPLYSLLAAD- EDTLKKP-----DKV-----------GSVSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFQ--TPSMAD --------------------LDPL-DNDQEEAGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTSLEQMSLMALADTIATTSTDFKDSQGTSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRVQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVARASLLKNNDPLDAAIFYLAMKKKAVVWGLY RSQKNAKMTEFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCIE KMQDLQLALVISRLYESEFETGSTYKKILQR------------HVLGQDKQ--------- ----------------------------------IQANQDPFLRSMAHWVLEDYSRALDT LLEQ---------PAN-----STSSGSAEAKCDTG------------------------- -------------SSPV-----------------------------------------ST CNP---------------------EVFNFYTYLRTHPLLLRRHLGSSE---KAKVG---- ------LTAEGRRADSISLEERRLFFTAAYAHLQAGCPMLALEVLSKMPKVRKHSQNIKQ EDAGIAA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSIRSKTGHAS DHDWSQTALNGYESDGN---SLS-----NSQSDSVLSFDWSQPSMSLPDESLELKWDTDK DD---EE-DD-E-EEE-TKNGYTGRTADSSS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDTQDAMYP LMETVT-----------------------------------------------EEDSEDS NDF-------------------------------------IAPS---------------- --------------D--------------------------------------------- --------DILAAQLKFTACLKILTNELRTLSTGYELEGGKLRYQLCQWLEKE------- ---------------------V-------------------------------------- VALQRCCSYKPCL----------------PELSVQADAPVSGLVEEEQ------------ ------------------------------------------------------------ ------------AGS--------------------------------------------- ----------------CRGGS--------------------------------------- ---------------------------Q-----------------------------RC- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSIQTAVT PCSQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTANLKTVVANPIIYLTNLSHDILQTINSFDSPPHPDVVINEIYVLHTLA ASLSACIYQCL----CDGHTH-------------------------------------S- --HVNDFTGTVYQ--------------SVLLSQKQPIRTLSMDESVQPNTSPAQWPG--- -----IASLFRLLS-SAGEESQPGLAMLLCEILTAVFLSLFVHGLATHSSNELFRIVAHP LNSKLWSTVFGGCARIP------------------------------------VIEKPTS PTRTPP------Q--------------------------------ASPSGS--------- ------------------------------------------------------------ DKKPRRFRLRSSRSGSKEEAGIE------------------HEGPSSPR---HVPVVE-- --------------------------------QESPSIFKERFVPPDLSIWDYFIAKPTL PPSESRIEYDSEESQGSE-D--E------DED-----D-EFEDVFDPNSPQREHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQVLQKRLEIFG GPPTKYISTNLNDEAAAPGPALLRHKALFEPSNTPFRTSNPSALPVKRLWQYLVKQEVVQ ETFIRNIFTKKRDPNESGEDQTDSMKCSGMEETGNHQ-------------------TESD LGSPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EAEAKG-VGGDDFLVIHARDDCSALQGTTPYTHSSLGTPINMPWLGGLQTGRGAS----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGNAPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPGNSLVH--------------------AFCCHESGATVLSMAPRQQLL ITGGRKGWISVLELPHRLQRQTFQAHDSPVKALAVDPTEDCFISGSSEGNIKVWSMATQS PLYNFPNEHARQSLFRNLGTGVMQIEVGPANHIFSCGADGTMKMRILPNRY--------- ---SVVNHNNNNH-----------SNLKNDVKYII >ENSGWIP00000034902 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPVHHPDQK----------DTSLT------------KLTCQW QKTGQFVLPSMVRNLAWHPT---------------------------------------- ------------------------------------GGT-LLTGSTCLQLWSN------- --------L-EGVKKE---------AESRRN----------------------------- ------------PK----------------------EITDQS------------------ -----------------SAWRC-----------IW------------------------- --QSKTASPVSLMKFSPDGEFFATSG---------------LDDCLVKVWYSTIKWKSGV SRLFTSSKTTDTVQGELTYSFIYLAHPRSVTGFSWRKTSKYIS-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDNLLSG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------SNYTSGQHAESIRSAGLTKK- ------------------------------------------------------------ --------------------------------------------------------HTWD AKIPGQTTQDNYQDPEFSSYPDLLQLPLSGSLSDPQSQ---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -HCNHRKNCNRSSAIP-HANALCHFHIAASINPATDIPLLPSISSLNTVDDEEPAGPFIV HWLNNKELHFTLAMEVFLQQLRSSVEQ--------------------------------- ------------HTQCSSEG---------------------------------------- --------------LLSS-----------------LE----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PEDESNF-EDDNGSKASNPKGPEARE ---------------------------------------------------------LPL AAVEHQVDVLLEEWNKGADMLFSIHPIDGSLLVWHVDWLDEYQPGMFRQAQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVELAIQHGRQ----RPP-------------GSALPQTK SALISYGGQGKA-----------VP--------------------------GSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSQLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADNILAPPEACSSSGPFHST----------------------------- ------------------------------------------SLTCGSRPSRVSLGMVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANIAWLPTLIPSSCL--GAY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------LGKETQLLHVFEEDLILG------------------------ --------------------------------------SE-------------------- ----------------------------------------------RKESMQENPHSPHD GF-----------------------------SEA-------------------------- -------------AFSARFFLVVVELTPTGRSRLHMW----------------------- --------------------------------HLHLAARPV--------S---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EE---------SSPLNSSKFVYNNPG------------------SPITQ R-----------------NKPCTSNLQSASRLSLTTHKLYGQELALPAGVEAISVTPSAG HLSASCSLPAGRVPYLIATSCSDGKVRFWRCNVAAAE----------------------- ---SSGMDNEMYEWQEWPLQVEDRHPSSSAVSVPGRPVEVSCCNTGRFAVAY-------- ---------TQMPGT------------------------QLNSTFQLNLQGTLTS----- ---PPSTASSPYV-----------LFKSANNLMTPSLTVQHNPSFTL------------- -----------------------TPSPTNDREPQ-----------------------VY- --------------------------IGIFQCESNGGSQWMLEQTLVLD----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TWYPSANCG ASISRTEGVNKHNNK------------DFS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---VSFENCVGCTGKSLVHLDWVSQEDGSHILTVGIGTRIYMYGRLTGKPPELGLSSDAG RDQS----MSRLVLLRSVDLLSSVEGSLPNPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------A--------------- -----------------------------------PSKTRGAIGPDTDICSSISSISSVV RQCQDDVPFPGTNMSSLTLPKKSLSRSMMSLAQKLS---GKKTA-FDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVALKDNA-S-------- ---NPEKRVRSRTIS---VGGSTARDQKMFSK-AENSSPDYTEISSIPPLPLYALLAAD- EDT-PKP-----DKV-----------GSFSGD-----------------SGHGSS----- ------------------------------------------HTDAYDELFQ--ASNALD --------------------VNPL-DNDQEEAGN-------------------------- --------------------------------------KVIDLSLYSPTYFGPEHAQVLS SHLLHSSLPGLTRLEQMSLMALADTIASTSTDLNDIQAKSKGGETLDECGLKFLLAVRLH TFLSTSMPPAHRAQLLREG-------------LSTCHYAWAFHSEAEEELLHMLPVLQKG EPTWPELRSMGVGWWLRSTNKLRRCIEKVAKTSFQRNNDPLDAAIFYLALKKKAVIWGLY RSQKNIKMTEFFHNNFSEDRWRKAAMKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVITRLYEFEFETSSTYKKILHR------------HVLGHDKQ--------- ----------------------------------ITAHPDPFLRSIAHWVLEDYSSALDT LIEQ---------P-----------------------------------------VSSTN SGHPKISSDG---SSAV-----------------------------------------PT CNP---------------------EVFNFYTYLRNHPLLLRRHFGSSE---KAKVG---- ------LTAEGRMANSISLDERRLFFTAAYAHLHTGCPMLALEVLSKMPKVRKHSKP--- --------GDPV------------------------------------------------ -----------------GHPA--------------------------------------- ----------------------------------DLSGH-------------------TS EPDWSQHGLNGYESDGN---SFS-----NSHSDSVLSFDWSQPSITHTDEPLELKWDSDK DE---ED-ST-------------------------------------------------- ------------------------------------------------------------ -----------------------EDEPKNGKSVKAADTSG-------------------- ------------------------------------------------------------ -------------------------------------------------VFQD------- ----------------------------------------------LHDPASTGEDSENS EDY-------------------------------------ISPS---------------- --------------D--------------------------------------------- --------DILVSQLKFAACLKIMTNELRTLSTGYELDGGKLRYQLCQWLERE------- ---------------------V-------------------------------------- VALQHCCSYKPCL----------------PELSIHGEAPAAGLLEEEL------------ ------------------------------------------------------------ ------------PGS--------------------------------------------- ----------------PRGDN--------------------------------------- ---------------------------Q-----------------------------RR- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------E---ESPVT LTLQ-------------------------------------------------------- ------------------------------------------------------------ -PSSIPLLMACTANVKTVVANPIVHLTNLTHDILQTINAFDSPPHPDVVSNDIYVLHTLA ASLSACIYQCL----CDGHTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQPLRTLSMEDSVQPNTSPAQWPG--- -----IASLIRQLS-SAGEESQPALAVLLCEILTAVFLSLFVHGLATHSCNELFRIVAHP LSSKLWVTVFGGGARNP------------------------------------IIQKPNS PTRTPP------P--------------------------------ASPSGS--------- ------------------------------------------------------------ DRKSRRFRLLSSRSGSKEESITE------------------REGPSS-------PVVK-- --------------------------------QEAFSNFKEQFVAPELSIWDYFITKPSL PPSENGVDYDSEESYDSD-D--E-D----DED-----D-EYEDVFDPNSPKREHSNNNSY SWCLMRLTMIQLVLVNLKSFYPMAGYDLLDLPVASPLCHSVLKTLQRWEQVLQKRLEIFG GPPSKYISTHLQDETATQGPALLRHKALFEPSNTPFRSSHHSALPVRRLWLFLVKQEEIQ ETFIRNIFTKKPGSNQTLEDKTDNMKYSWMDETGNNQ-------------------TESD MGSPGGKSRIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDE- EAEVKS-VGGDEFLVVHTRDDFGSLHGTTPYTHSSPGTPISVPWLGGLQTGTGAA----L MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGDTPKPYL--TLQCHNKTANDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVY--------------------AFCCHDSGATVLSMAPRHQLL ITGGRKGLISVLQLSHRHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLATQS LLFTFANEHARQSLFRNLGTGVMQVEVGPTNHVFSCGADGTMKMRTLPNRF--------- ---SV--NNNNPL-----------GNIKNDVKFFI >ENSMMOP00000017320 MNLHQVLTGAVNPGDNCFSVGSVNSVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLDG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------QVGVSVESHLSVLKKFWPKSGCVFVYPGST-LLTGSDSLQLWSN------- ----------DGVKDE-------------------------------------------- --------------------------------------TEEE------KQA--------- --------EIITRDSH-SVWRC-----------TW------------------------- --QSMTASPVSLMKFSSDGEFFATAG---------------QDDCLLKVWYSTSKWKSGV FGLFTPPEPSIAVKGEVTFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ------------------------------------------------------YVCNVL LTCCKDSVCRLWAETLLPGDNFLSI----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------SNH------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----FNLQESLHTSIYRDVL---------------------------------------- ----------------------------------------------QPSLTGCLPHHQSR -HYNHKKS---GSKVP-HANALCHFHIAASINPATDIPLLPSISSLNSVDVEEPGGPFTV HWLNNKELHFALAMEVFLQQLQGCLEQ--------------------------------- ------------QNERSQEG--------------------------------------TE KYLELALKL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EPQGPEAVE ---------------------------------------------------------LSL AAVKHQVDVLLEEWNKSADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQVQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRK----RPP-------------GSMLPQTK SALISYGGQGKV-----------AA--------------------------SSSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEVDNILSPSEA--------------------------------------- ----------------------------------------------------LSLGAVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDTITD--------------------F------------ ------------------QGKETQLLHVFEEDLILGMLSLHLSFLTAP------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------CKP-------------------------- -------------AFSARFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAARPV--------T---------- --------MGECFEQSSQDVGEDVINCHSCF----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ R-----------------SKPCTSNLQSACRLSLTTHRLYSQEMALPEGVEAISVTPSAG HLSSSCSLPAGRVPYLLATSCSDGKVRFWRCNVIGTK----------------------- ---PSTMDNLVYQWEEWPLLVEENLPSSSVVSVQGRPIKVSCCHAGRIAIAY-------- ---------RKIPNT------------------------PLTSTFH-------------- ------------------------------------------------------------ --------------------------------PL-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLA----------- ------------------------------------------------------------ ----NTDPVAN------------------------------------------------- --YGI--STPGSAFIPSNM----------------------------------------- ---------------------------DFS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---IPNKHCQDSTSKSLVHLDWVSQENGSHVLTVGIGTKIFMYGGLSGKPPELCLPSDTS RDTS----LSRLVLLRSVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APPKPNAALAQDIDLSSSVYSIISVVRQSQEEDLSHGAHISSL---------------- ------------------------------------------------------------ -------------------PKRAMTRSMMSLAQKLS---GKRTV-YDLP----------- ---------------LLELMDLGKVRRAKAILSHLVKCIAGEIVALKDSS-A-------- ---NPDKRMGSRTIS---AGGSTARDRKMFSK-AENSTRDYTEISSIPPLPLYALLAAD- EDMSPKP------------------------D-----------------SGHGSS----- ------------------------------------------HNDNYDELFK--TPSIAD --------------------LDPL-DNDQEENGN-------------------------- --------------------------------------KVIDFSQYSPTYFGPEHANVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDL-DNEGKSKGGETLDECGLKFLLAVRLH TFLSTSLPLAHRAQLLRQG-------------LSTCHCAWAFHSEAEEELLNMLPALQKE ETTWPELRSMGVGWWLRSTNKLRRCIEKVARACVQRNNDPLDAAIFYLAMKKKAVVWGLY RSQKNAKMTEFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFEMASTYKKILQR------------HVLGQDKQV-------- KHLCCLTL-----DHSVYIYIL-----------------------IAYWVLEDYTRALDT LLEQ---------PAS-----YTS------------------------------------ -------------STPG-----------------------------------------SI CNP---------------------EVFNFYTYLRTHPLLLRRHFGSPD---KAKVG---- ------LTAEGRRADSISLVERRLFFTAAYAHMQAGCPMLALEVLSKMPKV--------- -----------CKYSN---P-------------RN--------HKDTMD----------- T-----------VGSKYGKP---------------------------------------- -----------------------------------------------------------S DSEWSQSALNGYESNGH---SIS-----HSQSDSVLSFDWSQPSLTLQDESLELKWDSDK DD---DE-ANEEDEEK-TKDDKSGRPADNSS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFHDTQEAMSP LLEFVM-----------------------------------------------GEDTEDS NDF-------------------------------------ITPS---------------- --------------N--------------------------------------------- --------DIMAAQLKFTACLKIMTNELRTLSTGYELEGGKLRYQLYQWLERE------- ---------------------V-------------------------------------- VALQHCCSYKPCL----------------PELCVQ---------EDEQ------------ ------------------------------------------------------------ ------------AGS--------------------------------------------- ----------------PL-DS--------------------------------------- ---------------------------Q-----------------------------RS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESHQVI KTSM-------------PCC---------------------------------------- ------------------------------------------------------------ ---Q-------------------------------------------------------- ------------------------------------------------------------ -QTSIPLLMACTANVKTVVANPIVYLTNLAHDILQTISALDSPPHPDFVNNEIYVMHTLA ASLSACIYQCL----CDGHTH-------------------------------------S- --HVNNFTGIVYQ--------------SVLLSQKQPVRTVSMDESVQPNTSPAQWPG--- -----IASLIRLLN-SAGEESQPGLAVLLCEILSAVFLSLFVHGLATHSSNELFRIVGHP LNSKLWVTVFGGGARIP------------------------------------VIQKPN- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------K------------------REGPCSPK---YYPVVE-- --------------------------------QEATSIFKERFVPPDLSIWDYFIAKPLL PPSESRIEYDSEESQSSQ-D--E------EDG-----D-EYEDAFESNAPHREHLNHNSY SWCLMRLAMVQLVVVNLKSFYPMAGYDLLDLPVGSPLCHAVLKTLQRWEQVLQRRLEIFG GPPSKYISTHLQDESATPGPALLRHKALFEPSNTPF--SHSSALPVKRLWQFLVKQEEVQ ETFIRHIFTKKRDP---------------------NE-------------------IESD LGFPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EVETK---GNDDFLVVHTRDDLAALHGTTPYTHSSPGTPINMPWLGGVQTGRGAS----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGALSLWQTNTSGNAPRPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNMCLWDTLVTPANSLVH--------------------AFCCHESGATVLAMAPRQQLL ISGGRKGWISILELPHKHQRQSFQAHDSPVKALAVDPTEDCLISGSSEGNIRVWSLATQS PLYTFPNEHARQSLFRNLGTGVMQIEVGPADHVFSCGADGTMKMRILPNRF--------- ---SV---NNNNH-----------SNLKNDVKFII >ENSCVAP00000016668 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSNFERLQIIPGAKHGNIQV GCVNCSQRDGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPIQHQDQKY----------TSST------------KLSCQW QKTGQFVLESMVRNLAWHPT---------------------------------------- ------------------------------------DGT-LLTGSGSLQLWSN------- --------A-DG-KD--------------------------------------------- --------------------------------------------------------DDEG REKPTRATE---RHSD-SGWRC-----------IW------------------------- --QSKTASPVSLIKFSPDGQFFATAG---------------QDDCLVKVWYSTNKWKSCV AQLFTPPDPSMSVQGELGFSFIYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLISG----------------------------------- -------------------------YH--------------------------------- ------------------------------------------------------------ ---------------------------------------SSH------------------ LSTPDGETVRSAAPSSK------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------HPCNGNTAGM SSQEFSFQESWHSSSYRDIP---------------------------------------- ----------------------------------------------QPSLTGGTSHHLNR -HHNHRRS--SNSGAP-HANALCHFHIAASINPATDIPLLPSISALSAVDDEEPGGLFTV HWLNNKELHFTLAMEVFLQQLGGSLEQ--------------------------------- ------------RNESPNE----------------------------------------- ------------------------------------DLYDED------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------NSDEEEN--RPSDSGGP--GE ---------------------------------------------------------LPV AAVEHQVDILLEEWNKGADMLFSIHPLDGSLLVWHVDWLDEYHPGMFRQTQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPT-------------GTSLSRTR SVLINYGSHGKA-----------AS--------------------------SSSLRLSIF TPNVLMISKHDDGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALK-------------------------- --------TPEADSILAPPESYS------------------------------------- --------------------------------------TNLPSLSRGSRPARVSLGGVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKEIQLLHVFEEELILG------------------------ --------------------------------------SV-------------------- ----------------------------------------------KTEDIQDVPCSPSI E-------------------AS---------SKP-------------------------- -------------AFSGHFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAACPV--------T---------- --------I--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EEPTGQKEINPVSPITGSQFIFDVPT------------------SPV-L K-----------------SKPCTSNLKSACRLSLTTHMLCSQEMALPQGVEVLSITPSAG HLSASCSLPSGRVPYLLATSCSDGKVRFWRCNVLRTE----------------------- ---PSTVDHLVYQWEEWRLLVEETLPNSSAVTIPGQPIKVSCCHSGRIAVAY-------- ---------RQATNP------------------------PLNSTPHLSSHRLLPS----- ---PPALSSSPF-------CNNAYL--------TPSLT---------------------- ----------LKPCP----SLALSPNPAITREPA-----------------------VH- --------------------------ISTFQCESTGGSQWILEQTIVLE----------- ------------------------------------------------------------ ----KTEPS------------TFCGSTDG---HAN------------------------- --------------HANNT----------------------------------------- ---------------------------DFSAANGN------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------CPGSANRSPVHLDWVSQEDGSHILTVGIGTKIYMYGRLSGKPPDLGLSSETN REQI----LSRLVLLRSVNLISSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -VPPKPSVTVVQDTDIGSSVSSILSAVR--QEDVFTTGPPTASLT--------------- -----------------------------------L------------------------ -------------------PKRSLTRSMMSLAQKLS---GKKTV-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVILKDNA-T-------- ---HPEKRVRSRTIS---VGGSTARDQKIFSK-SESSSPDYTEISSVPPLPLYALLAAD- EDT-PHL-----EKG-----------GSMSGD-----------------SGHGSS----- ------------------------------------------QTDAYDELFH--THNTLD --------------------LDPL-DNEEEETGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDNQDKSKGGETLDECGLKFLLAVRLH TFLLTSLPPVHRAQLLRQG-------------LSTCQYSWAFHSEAEEELLNMLPALQKG EPTWAELRAMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLAMKKKAVVWGLY RSQKNTKMTEFFHKNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVIARLYESEFETSSTYKKILQR------------HVLGQDK---------- -------------------------Q--------IPVHPDPFLRSIAYWVLEDYSGALDT LIEQ---------PAN-----CKSCGPSESKSDSG------------------------- -------------PSAM-----------------------------------------SA CNP---------------------EVFNFYIYLRTHPLLLRRHFSSSD---KAKVA---- ------LTTEVRRADSISLDERRLFFTTAYAHLHAGCPMLALEVLSKMPKVHKHSKV--- ----------------------------------SHPVLKGIPH---------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSRNGLSS EPDWSPPGLNGYHSDGN-----S-----NSRSDSVLSFDWSQPSVTLPDEPLELKWDSDK DC---ED-EE-----------------------EETNQEKSRKADNS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDRQD---- -------SVLTIAETVK------------------------------------SEESEDG NDF-------------------------------------IAPS---------------- --------------E--------------------------------------------- --------DIFLAHLKFTACLKIMSNELRTLSTGYELDGGKLRYQLCQWLERE------- ---------------------V-------------------------------------- VAHQRVCSYRPCL----------------PEQSVPGDGPVSGLVEEEQ------------ ------------------------------------------------------------ ------------PGS--------------------------------------------- ----------------PPGDI--------------------------------------- ---------------------------Q-----------------------------RS- ---------RRLWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSMRSVAA MNPQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLTACTVNVKTVVANPIVYLTNLTHDILQTINALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDGHKY-------------------------------------S- --HVNHFTGTVYQ--------------SILLSQKQALKAISMDEAVQPNTPPAQWPG--- -----VASLICLLS-SAGEEIQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIAAHP LNCNLWTTVFGGGARVP------------------------------------VMDKSSS PARTPP------P--------------------------------TSPSGS--------- ------------------------------------------------------------ DRKSRRFRLLSSRSGSKEESGIE------------------REGPSIPK-----IVVE-- --------------------------------QDTTSIFKEQFVPPELSIWDYFIAKPQL PPSESRVNYDSEESQDSQ-D--E-D----EDD-------EFGDVFEPNSPQREHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLELFG GPPSKYISTHLQDEITTPGPALLRHKALFEPSNTPFRNSHHSALPVKRLWQYLVKQDEVQ ETFIRNIFTKKPGTNQLVEDHPDIMKYSGVEEAGNSQ-------------------TESD LGCPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EVESKG-VGGDDFLVVHTRDDFASLHGTTPYTHSSPGTPINVPWLGGHQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRGPGHSRVTRIRFNHQ GNKFGIVDADGALSLWQTNTSGNTPKPYL--TLQCHNKTANDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLIH--------------------TFCCHESGATVLSMAQRRQLL LTGGRKGWITILELPHRHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLATQG LLYTFPNEHARQSLFRNLGTGVMQIEVGPSSHIFSCGADGTMKMRNLPNRFAVAE--NSS SPKS-------------------------DVKFFI >ENSPLAP00000012592 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------IKFSPDGQFFATAG---------------QDDCLVKVWYSTNKWKSCV AELFTPPEASVTVQGELTFSFIYLAHPRSVT----------------------------- ---------------------------------------GNITLKQQKKKFSNWAVCNVL LTCCKDSVCRLWAETLLPGDSLISG----------------------------------- -------------------------YH--------------------------------- ------------------------------------------------------------ ---------------------------------------SSH------------------ LFGPQGETVNS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ESWHSSSYRDIP---------------------------------------- ----------------------------------------------QPSLTGCLPHDQNQ -HHNHRRS--SNSGTP-HANALCHFHIAASINPATDIPLLPSISALSTVDDEEPGSLFTV HWLNNKELHFTLAMEVFLQQLGGSLEQ--------------------------------- ------------RNESSN------------------------------------------ ----------------------------------------------EGSVNYFQSVKYVA CYSKEI------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SS----------RM------------------------------------------SLPV AAVEHQVDVLLEEWNKGADMLFSIHPLDGSLLVWHVDWLDEYQPGMFRQTQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSSLSQTK SALISYGSLGKA-----------AP--------------------------SSSLRLSIF TPNVLMISKHDDGSLNQWAVSFAEDSAFSTVLSISHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSILAPAEAYS------------------------------------- --------------------------------------TSVPSFSHGSRPSRVSLGGVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISHQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEDLILG------------------------ --------------------------------------SM-------------------- ----------------------------------------------KTEDTQDTPQSPPT ------------------------------------------------------------ -------------AFSGRFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAACPV--------T---------- --------I--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VLIV-------------CSPA-Q K-----------------SKPCTSNLQSACRLSLTTHMLCSQEMALPQGVEVISVTPSAG HLSASCSLPSGRVPYLLATSCSDGKVRFWRCTALKTD----------------------- ---PSSVHSLVYQWEEWPLLVEETHPSSSAVSVPGRPIKVSCCHSGRIAVAY-------- ---------R-----------------------------------------LLQS----- ---PPALASSPF-------C---------------------------------------- ---------------------------------------------------------IH- --------------------------ISTFQCESTGGSEWILEQTIVLE----------- ------------------------------------------------------------ ----STDPT------------TFSSTSNG---HAN------------------------- --------------IPNST----------------------------------------- ---------------------------DFSTLNGN------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------CPGSANGSQVHLDWVSQEDGSHILTVGIGTKIYMYGRLSGKPPDLGLSSETN RDQS----LSRLVLLRSVNLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -VPPKPSVAAVQDTDVSSSISSIVSAVRQCQEDVFTTGAPTASLT--------------- -----------------------------------L------------------------ -------------------PKRSLTRSMMSLAQKLS---GKKTV-YDLPVEMEDSGLFEA AHQLSPTLPQYHPVQLLELLDLGKVHRAKAILSHLVKCIAGEIVILKDNA-T-------- ---HPEKRVRSRTIS---VGGSTARDQKIFNK-SESSSPDYTEISSVPPLPLYALLAAD- EDA-PHL-------------------------GEFEA-----------WSGHGSS----- ------------------------------------------QTDAYDELFH--THNTLD --------------------LDPL-DNEQEESGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDNQDKSKGGETLDECGLKFLLAVRLH TFLLTSLPPVHRAQLLRQG-------------LSTCQYAWAFHSEAEEELLNMLPALQKG EPTWAELRAMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLAMKKKAVVWGLY RSQKNTKMTEFFHNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFEISSTYKKILQR------------HVLGQDKQV-------- -------------------IISCVFQ--------IPVHPDPFLRSMAFWVLEDYSRALDT LIEQ---------PAN-----C-------------------------------------- -------------SSTM-----------------------------------------SA SNP---------------------EVFNFYIYLRTHPLLLRRHFSSSD---KAKVA---- ------LTTEVRRADSISLDERRLFFTTAYAHLHAGCPMLALEVLSKMPKVHKHSKV--- ----------------------------------SHHGVKDIPH---------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSKNGPAS EPDWSPPDLNGYHSDGN-----S-----NSRSDSVLSFDWSQPSMALPDEPLDLKWDSDK DE---ED-ED-----------------------EENVLENNKNTDNS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDRQD---- -------SMVTIAETLK------------------------------------SEESEDG DDF-------------------------------------IAPS---------------- --------------E--------------------------------------------- --------DIFLAHLKFTACLKIMSNELRTLSTGYELDGGKLRYQLCQWLERE------- ---------------------V-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q--------------------------MHTSTFLQKVGG FLCIVELTFCKFKFTK------------------HIWIHSLCL-------QDDSLKSAVA VNSQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLTACTVSVKTVVANPIVHLTNLTHDILHTINALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDGHKY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQRQTVKTVSLGEAVQPNTSPAQWPG--- -----IASLIHLLS-SAGEETQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIMAHP LNCKLWMTVFGGGARVP------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --KPRRFKLLSSRSGSREESGIE------------------REGPCSPK-----IVVE-- --------------------------------QEATSIFKEDFVPPDLSIWDYFIAKPEL PPSQNRVEYDSEESQDSQ-D--E-D----DED-----L-ESEDVFEPNLPQKEHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLELFG GPPAKYISTHLQDEIPTPGPALLRHKALFEPSNTPFRSSHHSVLPVKRLWQFLVKQEEVQ ETFIRNIFTKKPGTN---------------------Q-------------------TESD LGWPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDED- EVESKG-VGGDDFLVVHARDDFGSLHGTTPYTHSSPGTPINVPWLGGHQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGSTLKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD SRNVCLWDTLVTPANSLVH--------------------AFCCHDSGATVLSMAQRRQLL LTGGRKGCITILELPHRHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLATQG LLYHFPNEHARQSLFRNLGTGVMQIEVGPASHIFSCGADGTMKMRTLPNRFATAQSSSSS SPKG-------------------------DVKFFI >ENSPMEP00000025299 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSNFERLQIIPGAKHGNIQV GCVNCSQRGG-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------QVRIQRHTKKV---------------------------YFT CA----------------------------------GGT-LLTGSSSLQLWSS------- --------A-DG-KDE-------------------------------------------- -------------------------------------------SEEKGKQTK-------- ------------------------------------------------------------ ------------------------------------------DDCLVKVWYSTNKWKSCV AELFTPPEASVTVQGELTFSFIYLAHPRSVTGFSWRKTSKHMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLISG----------------------------------- -------------------------YH--------------------------------- ------------------------------------------------------------ ---------------------------------------SSH------------------ LFGPQGETVNSAGSSSK------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------HTCNGKSAGM SSQ-----E--------------------------------------------------- -----------------------------------------------PSLTGCLPHDQNQ -HHNHRRS--SNSGTP-HANALCHFHIAASINPATDIPLLPSISALSAVDDEEPGGLFTV HWLNNKELHFTLAMEVFLQQLGGSLEQ--------------------------------- ------------RNESSN------------------------------------------ ----------------------------------------------EGSVNYFQSVKDVA CYSKEIK----------------------------------------------------- ------------------------------------------------------------ --------------------------------------------EN--RPSDHQGPEGGE ---------------------------------------------------------LPV AAVEHQVDVLLEEWNKGADMLFSIHPLDGSLLVWHVDWLDEYQPGMFRQTQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSSLSQTK SALISYGSLGKA-----------AP--------------------------SSSLRLSIF TPNVLMISKHDDGSLNQWAVSFAEDSAFSTVLSISHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSILAPAEAYS------------------------------------- --------------------------------------TSVPSFSHGSRPSRVSLGGVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISHQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEDLILG------------------------ --------------------------------------SM-------------------- ----------------------------------------------KTEDTQDTPQSPPT ------------------------------------------------------------ -------------AFSGRFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAACPV--------T---------- --------I--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------AVQK-------------CSPV-Q K-----------------SKPCTSNLQSACRLSLTTHMLCSQEMALPQGVEVISVTPSAG HLSASCSLPSGRVPYLLATSCSDGKVRFWRCTALKTD----------------------- ---PSSVHSLVYQWEEWPLLVEETHPSSSAVSVPGRPIKVSCCHSGRIAVAY-------- ---------R-----------------------------------------LLQS----- ---PPALASSPF-------C---------------------------------------- ---------------------------------------------------------IH- --------------------------ISTFQCESTGGSEWILEQTIVLE----------- ------------------------------------------------------------ ----STDPT------------TFSSTSNG---HAN------------------------- --------------IPNST----------------------------------------- ---------------------------DFSTLNGN------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------CPGSANRSQVHLDWVSQEDGSHILTVGIGTKIYMYGRLSGKPPDLGLSSETN RDQS----LSRLVLLRSVNLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -VPPKPSVAAVQDTDVSSSISSIVSAVRQCQEDVFTTGAPTASLT--------------- -----------------------------------L------------------------ -------------------PKRSLTRSMMSLAQKLS---GKKTV-YDLPVEMEDSGLFEA AHQLSPTLPQYHPVQLLELLDLGKVHRAKAILSHLVKCIAGEIVILKDNA-T-------- ---HPEKRVRSRTIS---VGGSTARDQKIFNK-SESSSPDYTEISSVPPLPLYALLAAD- EDA-PHL-----EKG-----------GSMSGD-----------------SGHGSS----- ------------------------------------------QTDAYDELFH--THNTLD --------------------LDPL-DNEQEEPGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDNQDKSKGGETLDECGLKFLLAVRLH TFLLTSLPPVHRAQLLRQG-------------LSTCQYAWAFHSEAEEELLNMLPALQKG EPTWAELRAMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLAMKKKAVVWGLY RSQKNTKMTEFFHNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFEISSTYKKILQR------------HVLGQDKQVS------- -------------------IISCVFQ--------IPVHPDPFLRSIAFWVLEDYSRALDT LIEQ---------PHDYEDELC-------------------------------------- -------------SSTM-----------------------------------------SA SNP---------------------EVFNFYIYLRTHPLLLRRHFSSSD---KAKVA---- ------LTTEVRRADSISLDERRLFFTTAYAHLHAGCPMLALEVLSKMPKVHKHSKV--- ----------------------------------SHHGVKDIPH---------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSKNGPAS EPDWSPPDLNGYHSDGN-----S-----NSRSDSVLSFDWSQPSMALPDEPLDLKWDSDK DE---ED-ED-----------------------EENVLENNKKTDNS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDRQD---- -------SMVTIAETLK------------------------------------SEESEDG DDF-------------------------------------IAPS---------------- --------------E--------------------------------------------- --------DIFLAHLKFTACLKIMSNELRTLSTGYELDGGKLRYQLCQWLERE------- ---------------------V-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q--------------------------MHTSTFPQKVGA FLCIVELTFCKFKFTKMFPSYL---------ISVHIWIHSLCL-------QDDSLKSAVA VNSQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLTACTVSVKTVVANPIVHLTNLTHDILHTINALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDGHKY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQRQAVKTVSLGEAVQPNTSPAQWPG--- -----IASLIHLLS-SAGEETQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIMAHP LNCKLWMTVFGGGARVP------------------------------------VMDKAS- ---------------------------------------------TSPSGL--------- ------------------------------------------------------------ DQKPRRFKLLSSRSGSKEESGIE------------------REGPCSPK-----IVVE-- --------------------------------QEATSIFKEDFVPPDLSIWDYFIAKPEL PPSQNRVEYDSEESQDSQ-D--E-D----DED-----L-ESEDVFEPNLPQKEHSNHNSY SWCLMRLAMVQLVLVNLKSFYLMAGYDLLDLPVASPLCHTVLKTLQRWEQVLQKRLELFG GPPAKYISTHLQDEIPTPGPALLRHKALFEPSNTPFRSSHHSVLPVKRLWQFLVKQEEVQ ETFIRNIFTKKPGTN---------------------Q-------------------TESD LGWPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDED- EVESKG-VGGDDFLVVHARDDFGSLHGTTPYTHSSPGTPINVPWLGGHQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGSTLKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHDSGATVLSMAQRRQLL LTGGRKGCIAILELPHRHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLATQG LLYHFPNEHARQSLFRNLGTGVMQIEVGPASHIFSCGADGTMKMRTLPNRFATAQ--SGS SPKG-------------------------DVKFFI >ENSPREP00000020951 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVVLGSNFERLQIIPGAKHGNIQV GCVNCSQRGGL------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPVQLPDQK----------CT-LS------------KLSCQW QKTGQFVLESMVRNLAWHPT---------------------------------------- ------------------------------------GGT-LLTGSSSLQLWSN------- --------A-DG-KDE-------------------------------------------- -------------------------------------------SEEKGKQTKPTRPD--- --------------SN-STWRC-----------IW------------------------- --QSKTASPVSFIKFSPDGQFFATAG---------------QDDCLVKVWYSTNKWKSCV AELFTPPEASVTVQGELTFSFIYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLISG----------------------------------- -------------------------YH--------------------------------- ------------------------------------------------------------ ---------------------------------------SSH------------------ LFGPQGETVNSAGSSSK------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------HTSNGKSAGM SSQELSFQESWHSSSYRDIP---------------------------------------- ----------------------------------------------QPSLTGCLPHDQNQ -HHNHRRS--SNSGTP-HANALCHFHIAASINPATDIPLLPSISALSAVDDEEPGGLFTV HWLNNKELHFTLAMEVFLQQLGGSLEQ--------------------------------- ------------RNESSNE----------------------------------------- ------------------------------------ELDDEENSDEE------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------EN--RPSDHQGPEGGE ---------------------------------------------------------LPV AAVEHQVDVLLEEWNKGADMLFSIHPLDGSLLVWHVDWLDEYQPGMFRQTQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSSLSQTK SALISYGSLGKA-----------AP--------------------------SSSLRLSIF TPNVLMISKHDDGSLNQWAVSFAEDSAFSTVLSISHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSLLAPAEAYS------------------------------------- --------------------------------------TSVPSFSHGSRPSRVSLGGVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISHQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKEIQLLHVFEEDLILG------------------------ --------------------------------------SM-------------------- ----------------------------------------------KTEDTQDTPQSPST G--------------------C---------SKP-------------------------- -------------AFSGRFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAACPV--------T---------- --------I--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EEATIHTEINAASPITGSQFVFDIPS------------------SPV-Q K-----------------SKPCTSNLQSACRLSLTTHMLCSQEMALPQGVEVISVTPSAG HLSASCSLPSGRVPYLLATSCSDGKVRFWRCTALKTD----------------------- ---PSSVHSLVYQWEEWPLLVEETHPSSSAVSVPGRPIKVTCCHSGRIAVAY-------- ---------RQTTNP------------------------QLNSAPHLNTHKLLQS----- ---PPVLASSPF-------CSITHI--------TPTLT---------------------- ----------LQPCQ----SLALSPNSANTKEPA-----------------------VH- --------------------------ISTFQCESTGGSQWILEQTIVLE----------- ------------------------------------------------------------ ----STDPT------------TFSSTSNG---RAN------------------------- --------------FPNST----------------------------------------- ---------------------------DFSILNGN------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------CPGSANRSQVHLDWVSQEDGSHILTVGIGTKIYMYGRLSGKPPDLGLSSDTN RDQS----MSRLVLLRSVNLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -VPPKPSVTVVQDTDVSSSVSSIVSAVRQCQEDVFTTGAPTASLT--------------- -----------------------------------L------------------------ -------------------PKRSLTRSMMSLAQKLS---GKKTV-YDLPVEMEDSGLFEA AHQLSPTLPQYHPVQLLELLDLGKVHRAKAILSHLVKCIAGEIVILKDNA-T-------- ---HPGKRVRSRTIS---VGGSTARDQKIFNK-SESSSPDYTEISSVPPLPLYALLAAD- EDA-PHL-----EKG-----------GSMSGD-----------------SGHGSS----- ------------------------------------------QTDAYDELFH--THNTLD --------------------LDPL-DNEQEEPGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDNQDKSKGGETLDECGLKFLLAVRLH TFLLTSLPPVHRAQLLRQG-------------LSTCQYAWAFHSEAEEELLNMLPALQKG EPTWAELRAMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLAMKKKAVVWGLY RSQKNTKMTEFFHNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFEISSTYKKILQR------------HVLGQDK---------- -------------------------Q--------IPVHPDPFLRSIAFWVLEDYSRALDT LIEQ---------PAN-----CKSSGPSQNKCDGG------------------------- -------------SSTM-----------------------------------------SA SNP---------------------EVFNFYIYLRTHPLLLRRHFSSSD---KTKVA---- ------LTTEVRRADSISLDERRLFFTTAYAHLHAGCPMLALEVLSKMPKVHKHSKV--- ----------------------------------SHHGVKDIPH---------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSRNGPAS EPDWSPPDLNGYHSDGN-----S-----NSRSDSVLSFDWSQPSMALPDEPLDLKWDSDK DE---ED-ED-----------------------EENVLENDKKADNG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDRQD---- -------SMVTIAETVK------------------------------------SEESEDG DDF-------------------------------------IVPS---------------- --------------E--------------------------------------------- --------DIFLAHLKFTACLKIMSNELRTLSTGYELDGGKLRYQLCQWLERE------- ---------------------V-------------------------------------- VSHQHVCSYKPCL----------------PERSVSGDGPVSGLVEEEQ------------ ------------------------------------------------------------ ------------PGS--------------------------------------------- ----------------PRSDS--------------------------------------- ---------------------------Q-----------------------------KS- ---------RRLWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ------------------------------------------------------------ --------------------------------------------------QDDSLKSAVA VNSQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLTACTVSVKTVVANPIVHLNNLTHDILHTINALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDGHKY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQAVKTVGLGEAVQPNTSPAQWPG--- -----IASLIRLLS-SAGEETQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIVAHP LNCKLWMAVFGGGARVP------------------------------------VMDKASS PARTPP------T--------------------------------TSPSGL--------- ------------------------------------------------------------ DRKPRRFRLLSSRSGSREESGIE------------------REGPCSPK-----IVVE-- --------------------------------QEATSIFKEDFVPPDLSIWDYFIAKPEL PPSQNRVEYDSEESQDSQ-D--E-D----DED-----L-ESEDVFEPNVPQKEHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLELFG GPPAKYISTHLQDEIPTSGPALLRHKALFEPSNTPFRSSHHSVLPVKRLWQYLVKQEEVQ ETFIRNIFTKKPGTNQSVEDHTDSMKYSGVEEAGNSQ-------------------TESD LGCPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDED- EVESKG-VGGDDFLVVHARDDFGSLHGTTPYTHSSPGTPINVPWLGGHQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGSTLKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHDSGATVLSMAQRRQLL VTGGRKGWITILELPHRHQWQSFQAHDSPIKALAVDPTEDCFISGSAEGNIKVWSLATQG LLHHFPNEHARQSLFRNLGTGVMQIEVGSARHIFSCGADGTMKMRTLPNRFAATQ--SSS SPKG-------------------------DVKFFI >ENSPFOP00000004010 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVVLGSNFERLQIIPGAKHGNIQV GCVNCSQRGGQ------------------------------------------------- ------------------------------------------------------------ ------IASSYGSIVCVFEPVHLPDQK----------CTSSS------------KLSCQW QKTGQFVLESMVRNLAWHPT---------------------------------------- ------------------------------------GGT-LLTGSSSLQLWSS------- --------A-DG-KDE-------------------------------------------- -------------------------------------------SEEKGKRTKATRPD--- --------------SN-STWRC-----------IW------------------------- --QSKTASPVSFIKFSPDGQFFATAG---------------QDDCLVKVWYSTNKWKSCV AELFTPPEASVTVQGELTFSFIYLAHPRSVTGFSWRKTSKHMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLISG----------------------------------- -------------------------YH--------------------------------- ------------------------------------------------------------ ---------------------------------------SSH------------------ LFGPQGETVNSAGSSSK------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------HTCNGKSAGM SSQELSFQESWHSSSYRDIP---------------------------------------- ----------------------------------------------QPSLTGCLPHDQNQ -HHNHRRS--SNSGTP-HANALCHFHIAASINPATDIPLLPSISALSAVDDEEPGSLFTV HWLNNKELHFTLAMEVFLQQLGGSLEQ--------------------------------- ------------RNESSN------------------------------------------ ----------------------------------------------EGSVNYFQSVKYVA CY----K----------------------------------------------------- ------------------------------------------------------------ ----------------------------------LDDEENSDEEEN--RPSDHQGPEGGE ---------------------------------------------------------LPV AAVEHQVDVLLEEWNKGADMLFSIHPLDGSLLVWHVDWLDEYQPGMFRQTQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSSLSQTK SALISYGSLGKA-----------AP--------------------------SSSLRLSIF TPNVLMISKHDDGSLNQWAVSFAEDSAFSTVLSISHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSILAPAEAYS------------------------------------- --------------------------------------TSVPSFSHGSRPSRVSLGGVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCLASGVY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISHQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEDLILG------------------------ --------------------------------------SM--WNNILSVIGAHFPA---- ------------------------------------------------------------ G--------------------C---------SKP-------------------------- -------------AFSGRFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAACPV--------T---------- --------I--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EEATIQKEINAASPITGSQFVFDIPS------------------SPA-Q K-----------------SKPCTSNLQSACRLSLTTHMLCSQEMALPQGVEVISVTPSAG HLSASCSLPSGRVPYLLATSCSDGKVRFWRCTALKTD----------------------- ---PSSVHSLVYQWEEWPLLVEETHPSSSAVSVPGRPIKVSCCHSGRIAVAY-------- ---------RQT------------------------------------------------ ------------------------------------------------------------ ------------------------PNSANTKEPS-----------------------VH- --------------------------ISTFQCESTGGSEWILEQTIVLE----------- ------------------------------------------------------------ ----STDPT------------TFSSTSNG---HAN------------------------- --------------IPNST----------------------------------------- ---------------------------DFSTLNGN------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------CPGSANGSQVHLDWVSQEDGSHILTVGIGTKIYMYGRLSGKPPDLGLSSETN RDQS----LSRLVLLRSVNLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -VPPKPSVAAVQDTDVSSSISSIVSAVRQCQEDVFTTGAPTASLT--------------- -----------------------------------L------------------------ -------------------PKRSLTRSMMSLAQKLS---GKKTV-YDLPVEMEDSGLFEA AHQLSPTLPQYHPVQLLELLDLGKVHRAKAILSHLVKCIAGEIVILKDNA-T-------- ---HPEKRVRSRTIS---VGGSTARDQKIFNK-SESSSPDYTEISSVPPLPLYALLAAD- EDA-PHL-----EKG-----------GSMSGD-----------------SGHGSS----- ------------------------------------------QTDAYDELFH--THNTLD --------------------LDPL-DNEQEESGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDNQDKSKGGETLDECGLKFLLAVRLH TFLLTSLPPVHRAQLLRQG-------------LSTCQYAWAFHSEAEEELLNMLPALQKG EPTWAELRAMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLAMKKKAVVWGLY RSQKNTKMTEFFHNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFEISSTYKKILQR------------HVLGQDKQVST------ --LYK-------------PM--------------IPVHPDPFLRSIAFWVLEDYSRALDT LIEQ---------PAN-----CKSC----------------------------------- -------------SSTM-----------------------------------------SA SNP---------------------EVFNFYIYLRTHPLLLRRHFSSSD---KAKVA---- ------LTTEVRRADSISLDERRLFFTTAYAHLHAGCPMLALEVLSKMPKVHKHSKV--- ----------------------------------SHHGVKDIPH---------------- ------------------------------------------------------------ -----------------------------------------------E-LSIGSKNGPAS EPDWSPPDLNGYHSDGN-----S-----NSRSDSVLSFDWSQPSMALPDEPLDLKWDSDK DE---ED-ED-----------------------EGNVLENNKKTDNS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDRQD---- -------SMVTIAETLK------------------------------------SEESEDG DDF-------------------------------------IAPS---------------- --------------E--------------------------------------------- --------DIFLAHLKFTACLKIMSNELRTLSTGYELDGGKLRYQLCQWLERE------- ---------------------V-------------------------------------- VSHQHVCSYKPCL----------------PERSVSGDGPVSGLVEEE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QS---------------------------------------DSLQREMFMFLLCVYF KRCEEFLLKSHTSLLPMFSSFLFNCQSHTQRKILVEIINLFLMNLQTFRILVNIFDKPVR KPTSIPLLTACTVSVKTVVANPIVHLTNLTHDILHTINALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDGHKYSS---------------------------------SDS- --HVNHFTGTVYQ--------------SVLLSQRQAVKTVSLGEAVQPNTSPAQWPG--- -----IASLIHLLS-SAGEETQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIMAHP LNCKLWMTVFGGGARVP------------------------------------VMDKASS PARTPP------TSDCF------AFF-------------------G-------------- ------------------------------------------------------------ -----------------EESGIE------------------REGPCSPK-----IVVE-- --------------------------------QEATSIFKEDFVPPDLSIWDYFIAKPEL PPSQNRVEYDSEESQDSQ-D--E-D----DED-----L-ESEDVFEPNLPQKEHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLELFG GPPAKYISTHLQDEIPTPGPALLRHKALFEPSNTPFRSSHHSVLPVKRLWQFLVKQEEVQ ETFIRNIFTKKPGTN---------------------Q------------------ISAAD LGWPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDED- EVESKG-VGGDDFLVVHARDDFGSLHGTTPYTHSSPGTPINVPWLGGHQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGSTLKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHDSGATVLSMAQRRQLL LTGGRKGCITILELPHRHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLATQG LLYHFPNEHARQSLFRNLGTGVMQIEVGPASHIFSCGADGTMKMRTLPNRFATAQ--SGS SPKG-------------------------DVKFFI >ENSXMAP00000016429 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVVLGSNFERLQIIPGAKHGNIQV GCVNCSQRGGQ------------------------------------------------- ------------------------------------------------------------ --------------------------------------V--------------------- ---------------------RIKRMYKKV---------------------------YFT CA----------------------------------GDT-LLTGSSSLQLWSN------- --------T-DG-KDE-------------------------------------------- -------------------------------------------SEEKGKQTKPTRPD--- --------------SN-STWRC-----------IW------------------------- --QSKTASPVSFIKFSPDGQFFATAG---------------QDDCLVKVWYSTNKWKSCV AELFTPPDASVSEQGELNFSFIYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRMWAETLLPGDSLISG----------------------------------- -------------------------YH--------------------------------- ------------------------------------------------------------ ---------------------------------------SSH------------------ LFGPQGETVNSAASSSK------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------HTCNGKS--- ------------------------------------------------------------ -----------------------------------------------PSLTGCLPHDQNQ -HHNHRRS--SNSGTP-HANALCHFHIAASINPATDIPLLPSISALSAVDDEEPGGLFTV HWLNNKELHFTLAMEVFLQQLGGSLEQ--------------------------------- ------------RNESSNEV---------------------------------------- -----------------HQCLH-----------SISEL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DDEENSDEEEN--RPSDPQCPEGGE ---------------------------------------------------------LPV AAVEHQVDVLLEEWNKGADMLFSIHPLDGSLLVWHVGWLDEYQPGMFRQTQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSSLSQTK SALISYGSLGKA-----------AP--------------------------SSSLRLSIF TPNVLMISKHDDGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSILAPAEAYS------------------------------------- --------------------------------------TGVPSFSHGSRPSRVSLGGVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GMY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEDLILG------------------------ ------------------------------------------------------------ --------------------------------------------SMKTEDTQDTPQSPST ------------------------------------------------------------ -------------AFSGHFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLVACPV--------T---------- --------I--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EEATIQKEINAVSPITGSQFIFDIPS------------------SPV-Q K-----------------SKPCTSNLQSACRLSLTTHMLCSQEMALPQGVEVISVTPSAG HLSASCSLPSGRVPYLLATSCSDEKVRFWRCTALKTD----------------------- ---PSSVHSLVYQWEEWPLVVEETHPNSSTVSVPGRPIKVSCCHSGRIAVAY-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SPNSANMKEPA-----------------------VH- --------------------------ISTFQCESTGGSQWILEQTIALE----------- ------------------------------------------------------------ ----STDPT------------TFSSTSNG---PAN------------------------- --------------IPNNT----------------------------------------- ---------------------------DFSTLNGN------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------CPGSANRSQVHLDWVSQEDGSHVLTVGIGTKIYMYGRLSGKPPDLGLSSETN RDQS----LSRLVLLRSVNLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -VPPKPSVTVVQDADISSSVSSIVSAVRQCQEDVFTTGAPTAFLT--------------- -----------------------------------L------------------------ -------------------PKRSLTRSMMSLAQKLS---GKKTV-YDLPVELEDSGLFEA AHQLSPTLPQYHPVQLLELLDLGKVNRAKAILSHLVKCIAGEIVILKDNA-T-------- ---HPEKRVRSRTIS---VGGSTARDQKIFNK-SESSSPDYTEISSVPPLPLYALLAAD- EDA-PHL-----EKG-----------GSMSGD-----------------SGHGSS----- ------------------------------------------QTDAYDELFH--THNTLD --------------------LNPL-DNEQEEPGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDNQDKSKGGETLDECGLKFLLAVRLH TFLLTSLPPVHRAQLLRQG-------------LSTCQYAWAFHSEAEEELLNMLPALQKG EPTWAELRAMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLAMKKKAVVWGLY RSQKNTKMTEFFHNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETSSTYKKILQR------------HVLGQDKQVS------- -------------------IISCVFQ--------IPVHPDPFLRSIAFWVLEDYSKALDT LIEQ---------PTN-----CKS------------------------------------ -------------SSTM-----------------------------------------SA SNP---------------------EVFNFYIYLRTHPLLLRRHFSSSD---KAKVA---- ------LTTEVRRADTISLDERRLFFTTAYAHLHTGCPMLALEVLSKMPKVHKHSKV--- ----------------------------------SQHGVKDIPN---------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSRNGPAS EPDWSPPGLNGYQSDGN-----S-----NSRSDSVLSFDWSQPSMTLPAEHLELKWDSDK DE---ED-ED-----------------------EDDVPENNIKTDNS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDRQD---- -------SMLTIAEMVK------------------------------------SEENEDG DDF-------------------------------------IAPS---------------- --------------E--------------------------------------------- --------DIFLAHLKFTACLKIMSNELRTLSTGYELDGGKLRYQLCQWLERE------- ---------------------V-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------QTHNSTFLQKVVAFLSIVELTFCKFKLELVQV- ---------RRLWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------QVNKRLFSSFLFNLD------------------------ ------------------------------------------------------------ --SQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLTACTVSVKTVVANPIVYLTNLTHDILHTINALDSPPHPDVVNNEIYVMHTLA ASLSACI----------------------------------------------------- -----------YQLWQNIFSFIIIYNSSVLLSQKQAVKTVSLGEAVQPNTSPAQWPG--- -----IPSLIRLLS-SAGEETQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIVAHP LNCKLWMTVFGGGARVP------------------------------------VMDKAS- ---------------------------------------------TSPSGL--------- ------------------------------------------------------------ DRKPRRFRILSSRSGSREESGID------------------REGPSSPK-----IVVE-- --------------------------------QEATSIFKEDFVPPDLSIWDYFIAKPEL PPSQNRVEYDSEESQDSQ-D--E-D----DED-----L-EFEDVFEPNLPAKEHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLELFG GPPPKYISTHLHDEILTPGPALLRHKALFEPSNTPFR---YHLLPVKRLWQYLVKQEEVQ ETFIRNIFTKKPGTN---------------------Q-------------------TESD LGCPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDED- EVESKG-VGGDDFLVVHARDDFGSLHGTTPYTHSSPGTPINVPWLGGHQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGSTLKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANNLVH--------------------AFCCHDSGATVLSMAQRRQLL LTGGRKGWITILELPHRHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLATQG LLYHFPNEHARQSLFRNLGTGVMQIEVGPASHIFSCGADGTMKMRTLPNRFAAAQ--SSS TPKS-------------------------DVKFFI >ENSGAFP00000004162 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVVLGSNFEQLQIIPGAKHGNIQV GCVNCSQRSGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPVHLPDQKYTS----SRVC---------------------- ----------------------------------------------------------FT CA----------------------------------GGT-LLTGSSSLQLWSN------- --------A-DG-TDE-------------------------------------------- -------------------------------------------SEEKGKQRKPTRPD--- --------------SN-STWRC-----------IW------------------------- --QSKTASPVSFIKFSPDGQFFATAG---------------QDDCLVKVWYSTNKWKSCV AELFTPPDASVSVQGELTFSFIYLAHPRSVTGFSWRKTSTYLP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLISG----------------------------------- -------------------------YH--------------------------------- ------------------------------------------------------------ ---------------------------------------SSH------------------ HFGPHGETVNSAGSSSK------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------HACNGKS--- ------------------------------------------------------------ -----------------------------------------------PSLTGCLPHDQNQ -HHNHRRS--SNSGTP-HPNALCHFHIAASINPATDIPLLPSISALSAVDDEEPGGLFTV HWLNNKELHFTLAMEVFLQQLGGSLEQ--------------------------------- ------------RNESSNEV---------------------------------------- -----------------------------------SEL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------DDDENSDEEEN--RPSDPQGPEGGE ---------------------------------------------------------LPV AGVEHQVDVLLEEWNKGADMLFSIHPLDGSLLVWHVDWLDEYQPGMFRQTQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GSSLSQTK SALISYRNLGKA-----------AP--------------------------SSSLRLSIF TPNVLMISKHDDGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSILAPAEAYS------------------------------------- --------------------------------------TGVPSFSHGSRPSRVSLGGVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPDISK--------------------Y VGEVFNIISQQSTAKPGCIIELDVITD--------------------F------------ ------------------QGKETQLLHVFEEDLILG------------------------ --------------------------------------ILLKWNNISTIICAHFPA---- --------------ACSKPT--------------------FSGD---------------- ------------------------------------------------------------ ------------------FFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLEACPV--------T---------- --------I--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EETTIQKEINAVSPMTGSQFIFDIPS------------------SPV-Q K-----------------SKPCTSNLQSACRLSLTTHMLCSQEMALPQGVEVISVTPSAG HLSASCSLPSGRVPYLLATSCSDEKVRFWRCTALKTD----------------------- ---PSSVHSVVYQWEEWSLLVEETHSNNSAVSVPGRPIKVSCCHSGRIAVAY-------- ---------R-----------------------------------------LL------- ----PALASSPF-------C---------------------------------------- ----------------------I-----------------------------------H- --------------------------ISTFQCESTGGSQWILEQTIALE----------- ------------------------------------------------------------ ----STDLT------------TFSSTSNG---PVN------------------------- --------------IPDNT----------------------------------------- ---------------------------DFSTLNGN------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------CPGSANRSQVHLDWVSQEDGSHVLTVGIGTKIYIYGRLSGKPPDLGLSSETN RDQS----LSRLVLLRSVNLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -VPPKPSVTVVQDADISSSVSSIVSAVRQCQEDVFTTGAPTASLT--------------- -----------------------------------L------------------------ -------------------PKRSLTRSMMSLAQKLS---GKKTV-YDLPVEMEDSGLFEA AHQLSPTLPQYHPVQLLELLDLGKVNRAKAILSHLVKCIAGEIVILKDNA-T-------- ---HPEKRVRSRTIS---VGGSTARDQKIFNK-SESSSPDYTEISSVPPLPLYALLAAD- ED----LCVAFAEKG-----------GSMSGD-----------------SGHGSS----- ------------------------------------------QTDAYDELFH--THNTLD --------------------LNPL-DNEQEEPGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDNQDNSKGGETLDECGLRFLLAVRLH TFLLTSLPPVHRAQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPTWADLRAMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLAMKKKAVVWGLY RSQKNTKMTEFFHNNFNEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETSSTYKKILQR------------HVLGQDKQVS------- -------------------IISCVFQ--------IPVHPDPFLRSIAFWVLEDYSKALDT LIEQ---------PAN-----CKI------------------------------------ -------------SSTM-----------------------------------------SA SNP---------------------EVFNFYIYLRTHPLLLRRHFSSTD---KAKVA---- ------LTTEVRRADSISLDERRLFFTTAYAHLHTGCPMLALEVLSKMPKVHKHSKV--- ----------------------------------SHHGAKDIPH---------------- ------------------------------------------------------------ -----------------------------------------------D-LSVGSRNGPAS EPDWSPPGMNGYQSDGN-----S-----NSRSDSVLSFDWSQPSMALPDEHLELKWDSDK DE---ED-ED-----------------------EENVPENNVKTDNS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDRQD---- -------SMLTIAETLK------------------------------------SEESEDG DDF-------------------------------------IAPS---------------- --------------E--------------------------------------------- --------DIFLAHLKFTACLKIMSNELRTLSTGYELDGGKLRYQLCQWLERE------- ---------------------V-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------QTHNSTFLQKVVAFLSTVELIFCKFKLE---S- ---------RRLWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q------------LDLVLPET-----IL----------- ------------------------------------------------------------ -NAQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLTACTVNVKTVVANPIVYLTNLTHDILHTINALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDGHKY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQAVKTVSLGEAVQPNTSPAQWPGKSH IFNFH----------SAGEETQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIVAHP LNCKLWMTVFGGGARVP------------------------------------VMDKASS PARTP--------------------V---------------------------------- ------------------------------------------------------------ ---------LSSRSGSREESGID------------------REEPPSPK-----VVVE-- --------------------------------HEATSIFKEHFVPPDLSIWDYFIAKPEL PPSQDRVEYDSEESQESQ-D--E-D----DED-----F-ESEDVFEPNLPQKEHSNHNSY SWCLMRLAMVQLVLVNLKSFYPVAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLELFG GPPAKYISTHPHDEIPTPGPALLRHKALFEPSNTPFRNNHHSVLPVKRLWQYLVKQEEVQ ETFIRNIFTKKPGTN---------------------Q-------------------TESD LGCPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDED- EVESKG-VGGDDFLVVHARDDFGSLHGTTPYTHSSPGTPISVPWLGGHQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGSTLKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHDSGATVLSMAQRRQLL LTGGRKGWITILELPHRQQQQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLATQG LLYHFPNEHARQSLFRNLGTGVMQIEVGPASHIFSCGADGTMKMRTLPNRFAAAQ--SSS TPKS-------------------------DVKFFI >ENSFHEP00000018320 MNLHQVLTGAVNPGDNCFSVGSVNNVPFTAYASGCDVVILGSNFERLQIIPGAKHGNIQV GCVNCSQRAGQ------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VSVRRCTKITVFVVELDICTGILQLMCKYLL CS----------------------------------GGT-LLTGSTSLQLWSN------- --------V-DG-KYE-------------------------------------------- -------------------------------------------SEEREKQTRTNKQD--- --------------TN-STWRC-----------IW------------------------- --QSKTASPVSFMKFSPDGQFFATAG---------------QDDCLVKVWYSTDRWKSCV AQLFTPPDANVSVQGELAFSFIYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLISG----------------------------------- -------------------------YH--------------------------------- ------------------------------------------------------------ ---------------------------------------SSH------------------ LSGPNGET---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AAPFAVITAAT------------------------------ -LLEFN-----LPVFQKTRNHSQT---------------------SKPSLTGCQPHHQNR -HHNHRRS--SNSGTP-HANALCHFHIAASINPATDIPLLPSISALSAVDDEEPGGLFTV HWLNNKELHFTLAMEVFLQQLEGSFEQ--------------------------------- ------------RNESPN------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EDNSDEEGN--RPSDSQVPEGGE ---------------------------------------------------------LPV AAVEHQVDVLLEEWNKGADMLFSIHPLDGSLLVWHVDWLDEYQPGMFRQTQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GTSLAQTK CALISYGSHGKA-----------AP--------------------------SSSLRLSIF TPNVLMISKHDDGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSVPAPPQAHS------------------------------------- --------------------------------------TGVPSFPHGSRPTRVSLGGVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPALIPSSCL--GAY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKEIQLLHVFEEELILG------------------------ --------------------------------------SV-------------------- ----------------------------------------------KTEETQDAPDSPPI --------------------AS---------SKP-------------------------- -------------AFSGRFFLVVVELTPTGGSLLHMW----------------------- --------------------------------HLHLAACPV--------T---------- --------I--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GGYFD----LKKIYLSPV-Q K-----------------SKPCTSNLQSACRLSLTTHVLCSQEMALPQGVEVISVTPSAG HLSASCSLPSGRVPYLLATSCSDGKVRFWRCSVLKTE----------------------- ---PASVDSLAYQWEEWPLLVGETLPNSSVVTVPGLPVKVSCCHSGRIAVAY-------- ---------R-----------------------------------------LLPS----- ---PPALASSPF-------SNNTHL----------------------------------- ------------------------------------------------------------ -------------------------------CESTGGSQWILEQTIVLE----------- ------------------------------------------------------------ ----STD-T------------TFSATSNGPNRRAN------------------------- --------------IPNNT----------------------------------------- ---------------------------DFSASNGN------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------CPGSASGSLVHLDWVSQEDGSHILTVGIGTKIYMYGRLSGKPPDLGLSSETN REQS----LSRLVLLRSVNLVSSVEGSVPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -VAPKPSAAVVQDADISSSISSIVSAVRQCQEDVFTNGAPTTSLT--------------- -----------------------------------L------------------------ -------------------PKKSLTRSMMSLAQKLS---GKKTV-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVVLKDNA-A-------- ---HPEKRVRSRTIS---VGGSTARDQKIFNK-SESSSPDYTEISSVPPLPLYALLAAD- EDT-PHL-----EKG-----------GSMSGD-----------------SGHGSS----- ------------------------------------------QADAYDELFH--THNTLD --------------------LDPL-DSEQEETGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDNQDKSKGGETLDECGLKFLLAVRLH TFLLTSLPPVHRAQLLRQG-------------LSTCQYAWAFHSEAEEELLNMLPALQKG EPTWAELRAMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLAMKKKAVVWGLY RSQKNTKMTEFFHNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETSSTYKKILQR------------HVLGHDKQVDS------ --LC------------------------------IPVHPDPFLRSVAHWVLEDYSRALDT LIEL---------PIQ-----CS------------------------------------- -------------SSSM-----------------------------------------SA CNP---------------------EVFNFYIYLRTHPLLLRRHFSSSD---RAKVA---- ------LTTEVRRADSISLDERRLFFTTAYAHLHAGCPMLALEVLSKMPKVHKHSKV--- ----------------------------------SHQGVKGLPH---------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSRNGLAS EPDWSPTGLNGYQSDGN-----S-----NSRSDSVLSFDWSQPSVTLPDEPLELKWDSDK DD---EDDED-----------------------EENNREKAKKADNS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDRQD---- -------SMLTLAETVK------------------------------------SEESEDS DAF-------------------------------------IAPS---------------- --------------E--------------------------------------------- --------DIFLAHLKFTACLKIMSNELRTLSTGYELDGGKLRYQLCQWLERE------- ---------------------V-------------------------------------- VAHQHVCSYMPCL----------------PEQAVPGDGPVSGLVEEEQVGVDCWFLTVKL DKENCS------------------------------------------------------ ------------I----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------RRLWLQSN----QPLLRMFLSYCSLHGCHGGGLASVRMELILLLQESH--- ---------------------Q------------------EIFMFPLLL----------- ------------------------------------------------------------ -NSQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTANVKTVVANPIVYLTNLTHDILQTITAFDSPPHPDVINNEIYVMHTLA ASLSACIYQCL----CDGHKY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQALKTASMDEAVQPNTSPAQWPG--- -----IASLIRLLS-SAGEETQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIVAHP LNCKLWMTVFGGGARIP------------------------------------VVDKTS- ---------------------------------------------TSPSGS--------- ------------------------------------------------------------ DRKPRRFRLLSSRSGSREESGIE------------------REEPSSLK-----IVVE-- --------------------------------QEATSIFKEQFVPPELSIWDYFIAKPEL PPSENRVEYDSEESQDSQ-D--E-D----DED-----N-ESEDVFEHNSPQKEHSNHNSY SWCLMRLAMVQLVLVNLKSFYPLAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLEIFG GPPSKYISTHLYDEITTPGPALLRHKALFEPSNTPF--SHYSALPVKRLWQYLVKQEEVQ ETFIRNIFTKTPGTN---------------------Q-------------------TESD LGCPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSAILATQILTWIDDD- DVETKS-VGGDEFLVVHARDDFASLHGTTPYTHSSPGTPINVPWLGGHQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGVVDADGGLSLWQTNTSGNTPKPYL--TLQCHNKTANDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVQ--------------------TFCCHESGATVLSMAQRRQLL LTGGRKGWITILELPHRHQRQSFQAHDSPVKALAVDATEDCFISGSAEGNIKVWSLATQC LLYSFPNEHARQSLFRNLGTGVMQIEVGPASHIFSCGADGTMKLRTLPNRFAAAG--SSC SPGS-------------------------DVKFFI >ENSKMAP00000001704 MNLHQVLTGAVNPGDNCFSVGNINNVPFTAYASGCDVVILGSNFERLQIIPGAKHGNIQV GCVNCSPQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCVFEPVLLTDQK----------DTSLS-----------------W QKTGQFALESMVRNLAWHPT---------------------------------------- ------------------------------------GST-LLTGSCSLQLWSN------- --------ADDG-KDE-------------------------------------------- -------------------------------------------AGERGKQTETPKQN--- --------------TH-STWRC-----------IW------------------------- --QSKTASPVSFMKFSPDGEFFATAG---------------QDDCLVKVWYSTNKWKSCV ARLFTPPDASVSLQGELAFSFVYLAHPRSVTGFSWRKTSKHMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPGDSLISG----------------------------------- -------------------------YH--------------------------------- ------------------------------------------------------------ ---------------------------------------DNH------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TSDHNSETVRCARKTQGMTPQEVRDFPSVTS SLL----------------------------------------------------HHQNQ -HHNHRR---SNIGPP-NANALCHFHIAASINPATDIPLLPSISSLNAVDDDEPGGLFTV HWLNNKELQFTLAMEVFLEQLRGSLEQ--------------------------------- ------------RNECTNE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------DEENSDEEDN--RP---------- -------------VELQGFD------------------------------------GLPV LAVEHQVDVLLEEWNKAADMLFSIHPIDGSLLIWHVDWLDEFQPGMFRQAQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHDRQ----RPP-------------GSSLSRTK STLISYGSQGKV-----------AP--------------------------SSSLRLSIF TPNVLMISKHDDGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEADSNLAPPEAHSC-----STFL--------------------------- --------------------------------------------PHGSRLSRVSLGGVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGQSLRLYQAVIEARKLLSELSNPEISK--------------------Y VGEVFNLVSQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEEDLILG------------------------ --------------------------------------SV-------------------- ----------------------------------------------RKEATLETPDSP-- ---------------------CNF---FFSTSKP-------------------------- -------------AFSGRFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLHLAARPV--------T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ KHYWPHKEQLSSYNNKQPSKPLTSNLQSTCRLSLTTHRLCSQEMALPAGVEAISVTPSAG HLSASCSLPAGRVPYLLATSCSDGKVRFWTCNVVSAE----------------------- ---LSSTDSLVYQWDEWPLLVEERLPSSSTVSVPGRPIEVSCCHTGRIAVAY-------- ---------REELNT------------------------PLYSTPHL------------- ------------------------------------------------------------ ---------------------------------------------------------MH- --------------------------ISIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----ATDST------------T-------------------------------------- ------------------------------------------------------------ ----------------------------------NSAAGSG------------------- -------P-----------------------------T---------------------- -----------------------------GSSSISNFH---------------------- -FSPPNEHCPGSASKSLVHLDWVSQEDGSHILTVSIGTKIYMYGRLSGKPPELGLSSDSN RDQS----LSRLVLLRLVNLVSSVEGSLPIPISLSWVRDGILVVGMECEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -VPPKPNGTVVQDTDISSSVSSIASAVRQYQEEGHNSAAPTSSLT--------------- -----------------------------------L------------------------ -------------------PKKSLTRSMMSLAQKLS---GKKTA-YDLPVEMEDSGLFEA AYQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVILKDNA-T-------- ---NPEKRVRSRTIS---VGGSTARDQKIFSK-AESSSPDYTEISSIPPLPLYALLAAD- EDT-PQL-----EKA-----------GSMSGD-----------------SGHGSS----- ------------------------------------------QTDAYDELFH--TPSTVD --------------------LDPL-DNGQEENGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDNQDKSKGGETLDECGLRFLLAVRLH TFLLTSLPPVHRAQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKG EPTWTELRSMGVGWWLRSTNKLRRCIEKVAKASFQRNNDPLDAAIFYLALKKKAVVWGLY RSQKNVKMTAFFHNNFNEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETASTYKKILQR------------YVLGHDKQVS------- -------------------VIFCLFQ--------IAAQPDPFLRSISYWVLEDYSRALDT LIEQ---------PAN-----C-------------------------------------- -------------SSAT-----------------------------------------SA CNP---------------------EVFNFYIYLRTHPLLLRRHFSSSD---KAKVA---- ------LTAEGRRADSISLDERRLFFTAAYAHLHAGCPMLALEVLSKMPKVRTHSKL--- ----------------------------------SSQGDTGIAP---------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSRNG-QS EPDWSPPGLNGYHSDGN-----S-----NSRSDSVLSFDWSQPSVTLPDEPLDLKWDSDK DD---DDEED-----------------------QDETKTEIKAADNS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFQDRQD---- -------SVLTIAETVK------------------------------------SDESEDG SEF-------------------------------------IAPC---------------- --------------D--------------------------------------------- --------DIFLAQLKFTACLKIMTTELRTLSTGYELDGGKLRYQLCQWLERE------- ---------------------V-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------QTFFIDA--------------------------------------P ASGLVEEEQVGVDSCLPRGDG--------------------------------------- ---------------------------Q-----------------------------RS- ---------RRLWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------RDIPLFESLKV---------------------------- --SQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTANVKTVVANPIVYLTNLAHDILHTIVALDSPPHDDVVNNEIYVMHTLA ASLSACIYQCL----CDGHKY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQPLKTVSMGEAVQPNTSPAQWPG--- -----IASLFRLLS-SAGEETQPGLAVLLCEILTAVFLSLFVHGMATHSSNELFRIVAHP LNSKLWMTVFGGGARIA------------------------------------LMDKPSS PARTPP------SSDCFVRSNFLT------------------------------------ ------------------------------------------------------------ -------------------SGIE------------------REGPSSPK---HGPVVE-- --------------------------------QEAASIFKEQFVPPELSIWDFFIAKPAL PPSENRIDYDSEQSQDSQ-D--E-D----DDE-----D-ESEDVFDLNSLQREHSNHNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVASPLCHSVLKTLQCWEQVLQKRLEIFG GPPAKYISTYLQDE-ATPGPALLRHKALLEPSNTPFRSNHYSALPVKRLWQYLVKQEEVQ ETFIRNIFIKKPSTN---------------------Q-------------------TESD LGCPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- ETETK---SGDDFLVVHARDDFASLHGTTPYTHSSPGTPINVPWLGGQQTGRGAS----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGSLSLWQTNTSGNASKPYL--TLHCHNKTAHDFIFVGSSSLISTAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFFCHETGATVLSMAPRQQLL ITGGRKGWITILELPQRNQRQSFQAHDSPVKALAVDPTEDCFISGSAEGNIKVWSLTTQC LLYTFLNEHARQSLFRNLGTGVMQVEVGPANHVFSCGADGTMKMRLLPNRFAAVD--SGD GSKR-------------------------DVKFFI >ENSORLP00020022904 MNLHQVLTGAVNPGDNCFSVGSINNMPFTAYASGCDVVILGSNFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSTVCVFEPVQPPDRK----------DAPLS------------KGNCQW QKAGQFVLESMVRNLAWHPT---------------------------------------- ------------------------------------GKS-LLTGSNSLQLWSN------- --------V-DGVKDE-------------------------------------------- -------------------------------------------GENRKKKN--------- --------QMTIQGSF-SAWRC-----------IW------------------------- --QNRTASPVCFMKFSPDGEFFATAG---------------QDDCLVKVWYSTNKWKSGV PTLFTPPDASVSVQGDLAFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------A--------------AVCNVL LTCCKDNVCRLWAETMLPGDSFLYG----------------------------------- -------------------------HF--------------------------------- ------------------------------------------------------------ ---------------------------------------NS------------------- ------------------------------------------------------------ --------------------PVSGYDGETVKCADRPEKNNF------------------- ------------------------------------------------------------ -----------------------------------------------------NGKTQGI TSQEFNFQESWHSGSYRDIP---------------------------------------- ----------------------------------------------VPSLTGCLPNHQSQ -HFTHKTS---SNEMP-HANALCHFHIAASINPATDIPLLPSISSLGAVNDEEPGGLFTV HWLNNKELHFTLSMEVFLQQLRSTLDE--------------------------------- ------------ENECSNE----------------------------------------- ------------------------------------E----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PEDEDTYDEEDNHSSPNDPKGDEGVE ---------------------------------------------------------LPV AALEHQVNVLSEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQTQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GTLLSQTK STLISYGCQVKA-----------AS--------------------------NNSLRLSIF TPNVLMISKHDDGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNELACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEAESILTPAEGHRI-SVSHST----------------------------- ------------------------------------------SLNCGSRPSRVSLGGVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISR--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEENLILG------------------------ --------------------------------------SL-------------------- ----------------------------------------------RAEGPQETPDS--- -----------------------I--FF---SEP-------------------------- -------------AFSARFFLVVVELTQTGRSLLHMW----------------------- --------------------------------QLHLAALPV--------I---------- --------L--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EETPTPKDLTTPSPMYNSQFLFDIPS------------------SPVIP R-----------------RKPSTTNLQTACRLSLTTRKLFSQELSLPPGVEAISFTPSAG HLSASCSLPAGRVPYLLASSCSDGKVRFWQCSVSAPE----------------------- ---PTSTDDFVYQWEEWTLLVDERLPNCSAVSVPGRPINVSCCHTGRIAVAY-------- ---------RQTPNA------------------------PLNSTPH--------SSSNGL PAFPPTLASSPY--------------------------------------------GFRN YTHPNQTPN-IQPVP----SLSVSPNPAKAREPL-----------------------VY- --------------------------ISIFQCDSTGGSQWILEQTIFLD----------- ------------------------------------------------------------ ----STDPTAG--------------------------SSAVKGVNLS------------- ----------------SNI----------------------------------------- ---------------------------DLS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---MPNDNCPGSANRAMVHLDWVSQEDGSHILTVGIGTRIYMYGCLSGKPPELVLSSDAK RDHS----LSRLVLLRSVSLVSSVDGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -VPPKPAFTTFQDTDTSSSVSSIVSAVRQFQEDGVTSAAPTPLLA--------------- -----------------------------------P------------------------ -------------------PKKALTRSMMSLAQKLS---GKKTV-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVTLKEST-T-------- ---NQEKRIRSRTIS---VGGSTARDEKIFSK-SESSSPDYTEISSVPPLPLYALLAAD- EDT-PQL-----EKG-----------GSVSGD-----------------SGHGSS----- ------------------------------------------QTDAYDELFH--TPNTVD --------------------LNLL-NEEQEETGS-------------------------- --------------------------------------KVIDLSKYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDNQAKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLCQG-------------LSTCHYAWAFHSEAEEELLNMLPAMQKG EPTWPELRSMGLGWWLRSTDKLRRCIEKVAKASFQKSNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETSSTYKKILQR------------HVLGQDKQ--------- ----------------------------------IPTHPDPFLRSIAYWVLEDYSRALDT LIVQ---------PSNLK-----SSGTSQIKCDTD------------------------- -------------SSSK-----------------------------------------PL CNP---------------------EVFNFYIYLRTHPLLLRRHFASCD---RAKVG---- ------LTTEGRRADSISLDERRLFFTTAYTHLQTGCPMLALEVLSKMPKVHKRSKLPNQ DDSSISA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSKNGPAS DPDWSRSALNGFDSAGN---SLS-----NSQSDSLLSFDWSQPSLNLPDEPLELKWDSDK DD---ED-AD-EDEE--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PQMTKEEKDCKTT ENS----------------------------------------------VFQD------- ------------------IPNAFPAGTESSRQSDLKDE---------------------- DDC-------------------------------------IVPS---------------- --------------D--------------------------------------------- --------DILVCQLKFTACLKIMANELRTLSTGYELEGGKLRYQLCQWLERE------- ---------------------V-------------------------------------- LALQRCCSYKPRL----------------PKASFQDDQSVSGLVEEDQ------------ ------------------------------------------------------------ ------------PHS--------------------------------------------- ----------------PRADS--------------------------------------- ---------------------------H-----------------------------KS- ---------RRQWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSVKSVKP LGSQ-------------------------------------------------------- ------------------------------------------------------------ -HTSIPLLMACTASVKTVVANPIVYLTNLAHDILQTINALDSPPHPDIVNNEIYVMHTLA ASLSACIYQCL----CDGHTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQLLRAVSTDESAQPNTSPAQWPG--- -----IASLIRLLN-SAGEDSQPGLAVLLCEILTAVYLSLFIHGMATHSSNELFRIVTHP LHGKLWVSVFGGGARIP------------------------------------VMGKPSS PTRTPP------P--------------------------------ASPSGS--------- ------------------------------------------------------------ EKKARRFRLLSSRGGSKEESGIE------------------REGPSSPK---FGSVVE-- --------------------------------HGVTSVFKDQFVPPELSIWDYFIAKPVL SPLENKVEYDSEESLSSQ-E--E-D----DDD-----D-ECDDVFEPSSPQKEHANNNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLEIFG GPPPKYISTHLQDESITPGPALLRHKALFEPCNTPFRASHSSALPVKRLWQYLVKQEELQ ETFIRNIFSKKHGT---------------------NQ-------------------TESD QNTGGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDE- EPEAKG-VGGDDFLVVHARDDFAALHGTTPYTHSSPGTPINVPWLGAMQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQITCFRSPGNSRVTRIRFNHQ GNKFGIVDADGALSLWQTSTSGNTPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLIH--------------------AFCCHDSGATVLSVAPKRQLL ITGGRKGWISVLELPNRHQRQSFQAHDSPVKALAVDSVEDCFISGSAEGNIKVWSLASQS LLYSFPNEHARQSLFRNLGTGVMQIEVGPANHVFSCGADGTMKMRSLPNRF--------- ---SV--V-TSSH-----------SNAGNNVKFFI >ENSORLP00015011920 MNLHQVLTGAVNPGDNCFSVGSINNMPFTAYASGCDVVILGSNFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSTVCVFEPVQPPDRK----------DAPLS------------KGNCQW QKAGQFVLESMVRNLAWHPT---------------------------------------- ------------------------------------GKS-LLTGSNSLQLWSN------- --------V-DCVKDE-------------------------------------------- -------------------------------------------GENRKKKN--------- --------QMTIQGSS-SAWRC-----------IW------------------------- --QNRTASPVCFMKFSPDGEFFATAG---------------QDDCLVKVWYSTNKWKSGV PTLFTPPDASVSVQGDLAFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------A--------------AVCNVL LTCCKDNVCRLWAETMLPGDSFLYG----------------------------------- -------------------------HF--------------------------------- ------------------------------------------------------------ ---------------------------------------NS------------------- ------------------------------------------------------------ --------------------PVSGYDGETVKCADRPEKNNF------------------- ------------------------------------------------------------ -----------------------------------------------------NGKTQGI TSQEFNFQESWHSGSYRDIP---------------------------------------- ----------------------------------------------VPSLTGCLPNHQSQ -HFTHKTS---SNEMP-HANALCHFHIAASINPATDIPLLPSISSLGAVNDEEPGGLFTV HWLNNKELHFTLSMEVFLQQLRSTLDE--------------------------------- ------------ENECSNE----------------------------------------- ------------------------------------E----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PEDEDTYDEEDNHSSPNDPKGDEGVE ---------------------------------------------------------LPV AALEHQVSVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQTQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GTLLSQTK STLISYGCQVKA-----------AS--------------------------NNSLRLSIF TPNVLMISKHDDGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNELACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEAESILTPAEGHRI-SVSHST----------------------------- ------------------------------------------SLNCGSRPSRVSLGGVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISR--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEENLILG------------------------ --------------------------------------SL-------------------- ----------------------------------------------RAEGPQETPDS--- -----------------------I--FF---SEP-------------------------- -------------AFSARFFLVVVELTQTGRSLLHMW----------------------- --------------------------------QLHLAALPV--------I---------- --------L--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EETPTPKDLTTPSPMYNSQFLFDIPS------------------SPVIP R-----------------RKPSTTNLQTACRLSLTTRKLFSQELSLPPEVEAISFTPSAG HLSASCSLPAGRVPYLLASSCSDGKVRFWQCSVSAPE----------------------- ---PTSTDDFVYQWEEWTLLVDERLPNCSAVSVPGRPINVSCCHTGRIAVAY-------- ---------RQTPNA------------------------PLNSTPH--------SSSNGL PAFPPTLASSPY--------------------------------------------GFRN YTHPNQTPN-IQPVP----SLSVSPNPAKAREPL-----------------------VY- --------------------------ISIFQCDSTGGSQWILEQTIFLD----------- ------------------------------------------------------------ ----STDPTAG--------------------------SSAVKGVNLS------------- ----------------SNY----------------------------------------- ---------------------------DLS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---MPNDNCPGSANRAMVHLDWVSQEDGSHILTVGIGTRIYMYGRLSGKPPELVLSSDAK RDQC----LSRLVLLRSVSLVSSVDGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -VPPKPAFTTFQDTDTSSSVSSIVSAVRQFQEDGVTFAAPTPLLA--------------- -----------------------------------P------------------------ -------------------PKKALTRSMMSLAQKLS---GKKTV-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVTLKEST-T-------- ---NQEKRIRSRTIS---VGGSTARDEKIFSK-SESSSPDYTEISSVPPLPLYALLAAD- EDT-PQL-----EKG-----------GSVSGD-----------------SGHGSS----- ------------------------------------------QTDAYDELFH--TTNTVD --------------------LNLL-NEEQEETGS-------------------------- --------------------------------------KVIDLSKYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDNQAKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLCQG-------------LSTCHYAWAFHSEAEEELLNMLPAMQKG EPTWPELRSMGLGWWLRSTDKLRRCIEKVAKASFQKSNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETSSTYKKILQK------------HVLGQDKQ--------- ----------------------------------IPTHPDPFLRSIAYWVLEDYCRALDT LILQ---------PSNLK-----SSGTSQIKCDTD------------------------- -------------SSSK-----------------------------------------PL CNP---------------------EVFNFYIYLRTHPLLLRRHFASCD---RAKVG---- ------LTTEGRRADSISLDERRLFFTTAYAHLQTGCPMLALEVLSKMPKVHKRSKLPNQ DDSSISA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSKNGPAS DPGWSRSALNGFDSAGN---SLS-----NSQSDSLLSFDWSQPSLNLPDEPLELKWDSDK DD---ED-AD-EDEE--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PQMTKEEKDCKTT ENS----------------------------------------------VFQD------- ------------------IPNAFPAGTESSRQGDFKDE---------------------- DDC-------------------------------------IVPS---------------- --------------D--------------------------------------------- --------DILVCQLKFTACLKIMANELRTLSTGYELEGGKLRYQLCQWLERE------- ---------------------V-------------------------------------- LALQRCCSYKPRL----------------PKASFQDDQSVSGLVEEDQ------------ ------------------------------------------------------------ ------------PQS--------------------------------------------- ----------------PHADS--------------------------------------- ---------------------------H-----------------------------KS- ---------RRQWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSVKSVKP LGSQ-------------------------------------------------------- ------------------------------------------------------------ -HTSIPLLMACTASVKTVVANPIVYLTNLAHDILQTINALDSPPHPDIVNNEIYVMHTLA ASLSACIYQCL----CDGHTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQLLRAVSTDESAQPNTSPAQWPG--- -----IASLIRLLN-SAGEDSQPGLAVLLCEILTAVYLSLFIHGMATHSSNELFRIVTHP LHGKLWVSVFGGGARIP------------------------------------VMGKPSS PTRTPP------P--------------------------------ASPSGS--------- ------------------------------------------------------------ EKKARRFRLLSSRGGSKEESGIE------------------REGPSSPK---FGSVVE-- --------------------------------HGVTSVFKDQFVPPELSIWDYFIAKPVL SPLEIRVEYDSEESLSSQ-E--E-D----DDD-----D-ECDDVFEPSSPQKEHANNNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLEIFG GPPPKYISTHLQDESITPGPALLRHKALFEPCNTPFRASHSSALPVKRLWQYLVKQEELQ ETFIRNIFTKKHGTNQS--DQADNMKCSGMDETGNNQ-------------------TESD QNSGGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDE- EPEAKG-VGGDDFLVVHARDDFAALHGTTPYTHSSPGTPINVPWLGAMQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQITCFRSPGNSRVTRIRFNHQ GNKFGVADADGALSLWQTSTSGNTPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLIH--------------------AFCCHDSGATVLSVAPKRQLL ITGGRKGWISVLELPNRHQRQSFQAHDSPVKALAVDSVEDCFISGSAEGNIKVWSLASQS LLYSFPNEHARQSLFRNLGTGVMQIEVGPANHVFSCGADGTMKMRSLPNRF--------- ---SV--V-NSSH-----------SNAGNNVKFFI >ENSORLP00000004343 MNLHQVLTGAVNPGDNCFSVGSINNMPFTAYASGCDVVILGSNFERLQIIPGAKHGNIQV GCVDCSLQGGQV------------------------------------------RIRRCS AFCNLLKMQ------------------------------------TFTFFLYPQYKES-- ------------------------------------------------------------ ---GQFVLETMVRNLAWHPT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GICRDTKYVFPPVSFLQDDCLVKVWYSTNKWKSGV PTLFTPPDASVSVQGDLAFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------A--------------AVCNVL LTCCKDNVCRLWAETMLPGDSFLYG----------------------------------- -------------------------HF--------------------------------- ------------------------------------------------------------ ---------------------------------------NS------------------- ------------------------------------------------------------ --------------------P--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----FNFQESWHSGSYRDIP---------------------------------------- ----------------------------------------------VPSLTGCLPNHQSQ -HFTHKTS---SNEMP-HANALCHFHIAASINPATDIPLLPSISSLGAVNDEEPGGLFTV HWLNNKELHFTLSMEVFLQQLRSTLDE--------------------------------- ------------ENECSN------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EDEDTYDEEDNHSSPNDPKGDEGVE ---------------------------------------------------------LPV AALEHQVNVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQTQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GTLLSQTK STLISYGCQVKA-----------AS--------------------------NNSLRLSIF TPNVLMISKHDDGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNELACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEAESILTPAEGHRI-SVSHST----------------------------- ------------------------------------------SLNCGSRPSRVSLGGVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISR--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------R-KETQLLHVFEENLILG------------------------ --------------------------------------SL-------------------- ----------------------------------------------RAEGPQETPDS--- -----------------------ICNIF---SES-------------------------- -------------AFSARFFLVVVELTQTGRSLLHMW----------------------- --------------------------------QLHLAALPV--------ILGGYVRHKIP HFSFFFNSL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------VIP R-----------------RKPSTTNLQTACRLSLTTRKLFSQELSLPPGVEAISFTPSAG HLSASCSLPAGRVPYLLASSCSDGKVRFWQCSVSAPE----------------------- ---PTSTDDFVYQWEEWTLLVDERLPNCSAVSVPGRPINVSC------------------ ------------------------------------------------------------ -SFPPTL----------------------------------------------------- ------------------------------------------------------------ -------------------------------CDSTGGSQWILEQTIFLD----------- ------------------------------------------------------------ ----STDPTAG--------------------------SSAVKGVNLS------------- ----------------SNI----------------------------------------- ---------------------------DLS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---MPNDNCPGSANRAMVHLDWVSQEDGSHILTVGIGTRIYMYGRLSGKPPELVLSSDAK RDHS----LSRLVLLRSVSLVSSVDGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQP-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------QFQEDGVTSAAPTPLLA--------------- -----------------------------------P------------------------ -------------------PKKALTRSMMSLAQKLS---GKKTV-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVTLKEST-T-------- ---NQEKRIRSRTIS---VGGSTARDEKIFSK-SESSSPDYTEISSVPPLPLYALLAAD- EDT-PQL-----EKG-----------GSVSGD-----------------SGHGSS----- ------------------------------------------QTDAYDELFH--TPNTVD --------------------LNLL-NEEQEETGS-------------------------- --------------------------------------KVIDLSKYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDNQAKSKGGETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLCQG-------------LSTCHYAWAFHSEAEEELLNMLPAMQKG EPTWPELRSMGLGWWLRSTDKLRRCIEKVAKASFQKSNDPLDAAIFYLALKKKAVVWGLY RSQKNAKMTEFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETSSTYKKILQRTEKKLFIKCFFP-------Q--------- ----------------------------------IPTHPDPFLRSIAYWVLEDYSRALDT LI---------------------------------------------------------- ----------------------------------------------------------PL CNP---------------------EVFNFYIYLRTHPLLLRRHFASCD---RAKVG---- ------LTTEGRRADSISLDERRLFFTTAYAHLQTGCPMLALEVLSKMPKVHKRSKLPNQ DDSSISA----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSVGSKNGPAS DPDWSRSALNGFDSAGN---SLS-----NSQSDSLLSFDWSQPSLNLPDEPLELKWDSDK DD---ED-AD-EDEE--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PQMTKEEKDCKTT ENS----------------------------------------------VFQD------- ------------------IPNAFPAGTESSRQGDLKDE---------------------- DNC-------------------------------------IVPS---------------- --------------D--------------------------------------------- --------DILVCQLKFTACLKIMANELRTLSTGYELEGGKLRYQLCQWLERE------- ---------------------VQIKI------------------YFFFFFHKSNEACNVF -----------------------------------------------Q------------ ------------------------------------------------------------ ------------PQS--------------------------------------------- ----------------PHADS--------------------------------------- ---------------------------H-----------------------------KS- ---------RRQWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ---------------------------------------------------DDSVKSVKP LGSQ-------------------------------------------------------- ------------------------------------------------------------ -HTSIPLLMACTASVKTVVANPIVYLTNLAHDILQTINALDSPPHPDIVNNEIYVMHTLA ASLSACIYQCL----CDGHTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQLLRAVSTDESAQPNTSPAQWPG--- -----IASLIRLLN-SAGEDSQPGLAVLLCEILTAVYLSLFIHGMATHSSNELFRIVTHP LHGKLWVSVFGGGARVP------------------------------------VMGKPTS PTRTPP------P----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VTSVFKDQFVPPELSIWDYFIAKPVL SPLENRVEYDSEESLSSQEE--E-D----DDD-----D-ECDDVFEPSSPQKEHANNNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLEIFG GPPPKYISTHLQDESITPGPALLRHKALFEPCNTPFRASHSSALPVKRLWQYLVKQEELQ ETFIRNIFTKKHGS---------------------NQ-------------------TESD QNSGGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDE- EPEAKG-YEGDDFLVVHARDDFAALHGTTPYTHSSPGTPINVPWLGAMQTGRGAA----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQITCFRSPGNSRVTRIRFNHQ GNKFGIVDADGALSLWQTSTSGNTPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLIH--------------------AFCCHDSGATVLSVAPKRQLL ITGGRKGWISVLELPNRHQRQSFQAHDSPVKALAVDSVEDCFISGSAEGNIKVWSLASQS LLYSFPNEHARQSLFRNLGTGVMQIEVGPANHVFSCGADGTMKMRSLPNRF--------- ---SV--V-NSSH-----------SNAGNNVKFFI >ENSOMEP00000018057 MNLHQVLTGAVNPGDNCFSVGSINNMPFTAYASGCDVVILGSNFERLQIIPGAKHGNIQV GCVDCSSQGGQVR-----------------------------------------RVRKCS AFCHLLKMQNFIFFLFTLQQMFKHPFSLRKENRKTQIHILTASAIS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------FLKFSPDGEFFATAG---------------QDDCLVKVWYSTNKWKSDV PRLFTPPDASVSVQGDLAFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------A--------------AVCNVL LTCCKDNVCRLWAETMLPGDSFLSG----------------------------------- -------------------------HF--------------------------------- ------------------------------------------------------------ ---------------------------------------SN------------------- ------------------------------------------------------------ --------------------PVSGHNGETVRCAD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------QSWHSSSYRDIP---------------------------------------- ----------------------------------------------VPSLTGCLPNRQSQ -HYTHKMS---SNEMP-HANALCHFHIAASINPATDIPLLPSISSLGAVNDEEPGGPFTV HWLNNKELHFTLSMEVFLQQLRSTLDE--------------------------------- ------------QNECSN------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EDEDTYDEEDDRSSPNDPKGHEGAE ---------------------------------------------------------LPV AALEHQVNVLLEEWNKGADMLFSIHPMDGSLLVWHVDWLDEYQPGMFRQTQVSFVSRIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GTSLSQTK STLISYGCQVKA-----------AS--------------------------SNSLRLSIF TPNVLMISKHDDGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNELACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEAESILTPAEENRI-SVSHST----------------------------- ------------------------------------------SLNCGSRPSRVSLGGVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGQSLRLYQAVIEAKKLLSELSNPEISR--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEENLILG------------------------ --------------------------------------SL-------------------- ----------------------------------------------RTEGLQETPDS--- -----------------------ICN---------------------------------- -------------TFSARFFLVVVELTQTGRSLLHMW----------------------- --------------------------------QLHLAALPV--------T---------- --------L--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EETPTPKDLTTTSPMYNSQFLFDIPS------------------SPVIP R-----------------RKPSTYNLQTACRLSLTTRKLFSQELPLPAGVKAISFTPSAG HLSASCSLPAGRVPYLLASSCSDGKVRFWKCSVSAPE----------------------- ---PTSAEDFIYQWEEWTLLVDERLPNCSAVSVPGRPINVSCCHTGRIAVAY-------- ---------RQTSNS------------------------PLNSTPH--------S----- ------------------------------------------------------------ -------------------------------EPL-----------------------VY- --------------------------ISIFQCDSTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----SADPTAT--------------------------SPAVKGANLS------------- ----------------SNI----------------------------------------- ---------------------------NLS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---VPTDNCLGSANRTMVHLDWVSQEDGSHVLTVGIGTKIYMYGRLSGKPPELVLSSDAK RDHS----LARLVLLRSVSLVSSVDGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQP-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------QFQEEGITSAAPTPLLA--------------- -----------------------------------P------------------------ -------------------PKKALTRSMMSLAQKLS---GKKTV-YDLPVEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVTLKEST-I-------- ---NQEKRIRSRTIS---VGGSTARDEKIFSK-SESSSPDYTEISSVPPLPLYALLAAD- EDT-PQL-----EKG-----------GSVSGD-----------------SGHGSS----- ------------------------------------------QTDAYDELFH--TPNIVD --------------------LNPL-NEDQEETGN-------------------------- --------------------------------------KVIDLSKYSPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDNQAKR--GETLDECGLKFLLAVRLH TFLSTSLPPAHRAQLLCQG-------------LSTCHYAWAFHSEAEEELLNMLPAMQKG EPTWPELRSMGLGWWLRSTDKLRRCIEKVAKAAFQKSNDPLDAAIFYLALKKKAVVWGLY RSQKNVKMTEFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETSSTYKKILQRTEKKPLIICFIF-------Q--------- ----------------------------------IPTHPDPFLRSIAYWVLEDYSRALDT LIEQ---------PSNLK----------------N------------------------- -------------SSSK-----------------------------------------PL CNP---------------------EVFNFYIYLRTHPLLLRRHFASSD---RAKVG---- ------LTTEGRRADSISLDERRLFFTTAYAHLQTGCPMLALEVLSKMPKVHKHSKLPNQ DDTSISG----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-L---SKNGPAS DPDWSQSALNGFDSAGN---SLS-----NSQSDSLLSFDWSQPSLNLPDEPLELKWDSDK DD---ED-ED-GDEE--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PQAAKEGKDGKTT DNS----------------------------------------------VFQD------- ------------------IHSAFPAGMETSRQSDLKDE---------------------- DDC-------------------------------------IVPS---------------- --------------D--------------------------------------------- --------DILVCQLKFTACLKIMTNELRTLSTGYELEGGKLRYQLCQWLERE------- ---------------------V-------------------------------------- LALQRCCSYKPCL----------------PKASFQDDQSVSGLVEEDQVGVDT------- ------------------------------------------------------------ -----------R------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------S- ---------RRQWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------QVNK----------------------------------- ------------------PC------------------------------------SVKP LGSQ-------------------------------------------------------- ------------------------------------------------------------ -QTSIPLLMACTANVKTVVANPIVYLTNLAHDILQTINALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDGHTY-------------------------------------S- --HVNHFTGTVYQ--------------SVLLSQKQLLRAVSTDESAQPNTSPAQWPG--- -----IASLIRLLN-SAGEDSQPGLAVLLCEILTAVYLSLFVHGMATHSSNELFRIVTHP LHSKLWVSVFGGGARIP------------------------------------VIGK--- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SKSGIE------------------REGPSSPK---FGSVVE-- --------------------------------HGVTSVFKDQFVPPDLSIWDYFIAKPVL SPLENRVEYDSEESLSSQ-E--E-D----DDD-----D-ECDDVFEPSSPQKEHANNNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPVASPLCHAVLKTLQRWEQVLQKRLEIFG GPPPKYISTHLQDESITPGPALLRHKALFEPCNTPF--SHSSALPVKRLWQYLVKQEELQ ETFIRNIFTQKHGT---------------------NQ-------------------AESD QNSAGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDE- EPEAKG-YEGDDFLVVHARDDFAALHGTTPYTHSSPGTPINVPWLGGMQTGRGAAMVSW- ---------RRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQITCFRSPGNSRVTRIRFNHQ GNKFGIVDADGALSLWQTNTSGITPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFCCHDSGATVLSVAPKRQLL ITGGRKGWISVLELPNRHQRQSFQAHDSPVKALAVDSVEDCFISGSAEGNIKVWSLASQS LLYTFPNEHARQSLFRNLGTGVMQIEVGPANHIFSCGADGTMKMRSLPNRF--------- ---SA--V-NSSH-----------GSAGNNVKFFI >ENSTRUP00000042924 MNLHQVLTGAVNPGDNCFSVGSINNVPFTAYASGCDVVILGSDFERLQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------VAASYGSTVCIFEPVQHQDQK----------DTSL------------------W QKTGQFILKSVVRNLAWHPS---------------------------------------- ------------------------------------GRS-LLTGSDSLQLWSN------- --------V-AGEDDE-------------------------------------------- -------------------------------------------AEE-------------- ------------------------------------------------------------ ---EKTASPVSLMKFSPDGEFFATAG---------------QDDCLVKVWYSTSKWRVGV SGLFTPPEPSIAVRGELSFSFVYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDGVCRLWAETLLPGDGHLSG----------------------------------- -------------------------YH--------------------------------- ------------------------------------------------------------ ---------------------------------------SNLTASQHSDT---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VKCAVAL- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------KPSLTGCLPHHQNR -HYSHKKS---GNKVP-HANALCHFHIAASINPATDIPLLPSISSLSCGDDEEPGGLFTV HWLNNKELHFTLAMEVFLQQLQGSLEQ--------------------------------- ------------QNESSQE----------------------------------------- --------------------------------------------D--------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------DEDGDSFDGEDDNSRP---------- -IDLEGSENLEHS----------------------------------------------L SAVKHQVDVLLEEWNKSADMLFSIHPIDGSLLVWHVDWLDEYQPGMFRQAQVSFVSCIPV AFPTGDAISLSHSVVMYACNKNVDLAIQHGRK----RPP-------------GSMMPQAK SALISYGGQRKI-----------AT--------------------------CSSLRLSIF TPNVLMISKHSDGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALK-------------------------- --------TPEVD-------------------IIRAQDTLFPSFFDSTSQ---------- ------------------P-------NR--------SIQ------------------VSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDTITE--------------------F------------ ------------------QGKETQLLHVFEEDLI------------------IVNSSIGV CCFLL------------------------------------------------------- ------------------------------------------------------------ --------------------VS---------SEP-------------------------- -------------AFSARFFLVVVELTPTGRSLLHMW----------------------- --------------------------------HLQLAARPV--------T---------- --------L--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EETAPDKEINTASPMNSSQFTFDMFG-SPG--------------TPV-M K-----------------NKPRTSNLQSACRLSLTTHRVYSQELALPEGVEAITVTPSAG HLSSSCSLPAGRVPYLLATSCSDGKVRFWRCNMSAVD----------------------- ---ACTKDNLLNQWEEWPLLVEETLPSSSAVSVPGCPIKVSCCHTGRIAVS--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------A-----------------------VH- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----RDDPTANH------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GSSNSSAGSADIPHVMGLMP KEYCQGPP-----------------------------T---------------------- ------------------------------------------------------------ --------------KNLVHLDWVSQENGSHILTVGIGTKIFMYGRLSGKPPELCLPSDAS RDRS----SPCLVLLRSVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APPK---TTAQDTDITSSFSSIISAVRQSQDDG---AGPGSLLS--------------- -----------------------------------L------------------------ -------------------PKRAVTRSMMSLAQKLS---GKRTA-YDLPVEMEDSGLFEA AQQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVTLVDST-A-------- ---SAEKRMRSRTIS---AGGSTA--AKMFNK-AEKSTSDYTEISSIPPLPLYALVAAD- ED--------------------------IAHD-----------------SGHDSS----- ------------------------------------------HTDTYDELFK--TISMAD --------------------LDPL-DSDQEETGC-------------------------- --------------------------------------KVIDLSQYCPTYFGPEHAQVLS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDL-----DSQGGETLDECGLKFLLAVRLH TFLSTSLPPAHRVQLLRQG-------------LSTCHYAWAFHSEAEEELLNMLPALQKE ETTWPELRSMGVGWWLRSTNKLRRCIEKVARASVQRNNDPLDAAIFYLAMKKKAVVWGLY RSQKNAKMTAFFRNNFSEDRWRKAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCLE KMQDLQLALVISRLYESEFETASTFKKILQR------------HVLGHDKQV-------- R------LLIISGN----------------------AHKDPFLRSIAYWVLEDYSKALDT LLEQ---------PY--------------------------------------------- -------------GSPV-----------------------------------------SS CNP---------------------EVFNFYTYLRTHPLLLRRHFASSD---KAKVG---- ------LTAEGRRADSISLEERRLFFTAAYAHLQAGCPMLALEVLSKMPRVCKHSILP-- ------------------------------------------------SHKNAGISTNLI T----------------------------------------------------------- ----------------------------------------------------GSRNQQTS DSDWSHSALNGYESDSH---SIS-----NSRSDSVLSFDWSQPSLTLPDESLELKWDSDK DD---EE----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------EVDQQDEDESEKNQSRRNADSSQIFRETHDSMSTVVGM-------------- -----------------------------------------------------GDDSEDS DDF-------------------------------------ITPS---------------- --------------N--------------------------------------------- --------DILAAQLKFTACLKIMTNELRTLSTGYELEGGKLRYQLYQWLERE------- ---------------------V-------------------------------------- LALQHCCSYKPCL----------------PELCIQ------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----EED--------PH-DN--------------------------------------- ---------------------------Q-----------------------------KS- ---------RRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------Q-------------------------------------- ------------------------------------------------------------ -VIQ-------------------------------------------------------- ------------------------------------------------------------ -QTSFPLLMACTANVKTVVANPIVYLTNLTHDILQTIIALDSPPHPDVVTNEV------- -------------MSC-----------------TLSVVIISCLAQCRFSTVEYS----P- --HVNNFTGTVYQ--------------SVLLSQKQHGRTFSMEESVQPNTSPAQWPG--- -----IASLCRLLS-SAGDENQPGLAVLLCEILTAVFLSLFVHGLATHSSNELFRIVGHP LNSKLWVTVFGGGARIP------------------------------------VVAKANS HTKSPP------P----------------------------------------------- ------------------------------------------------------------ ------------------------------------------EGPSSPK---PQPVVE-- --------------------------------QEAASIFKERFIHPDLSIWDYLITKPLL PPSESRIEYDSEESQSSQ-D--E------DDD-----D-EYEDPFDPNTPQREHSNHNSY SWCLMRLAMVQLVLVNLRSFFPMAGYDLLDLPACSPLCHAALKTLQRWEQVLQKRLQIFG GPPLKYISTPLQDE--APGPALLRHKALYEPSNTPFRTGHPSALPVKRLWQFLVKQEEVQ ETFIRYIFTKKRDP---------------------NQ-------------------IESD LSCPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDD- EVETKG-VGTDDFLVVHTRDDCAALHGTTPYTHSSLGTPINMPWLGGVQTGRGAS----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQILCFRSPGNSRVTRIRFNHQ GNKFGIVDADGALSLWQTNTSGNTPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPGSSLVH--------------------AFCCHDSGATVLAMAPRHQLL ITGGKKGWISILDLPHKHQRQSFQAHESPVKALAVDPTEDCFISGSSEGNIRVWSLATQS PLYTFPNEHARQSLFRNLGTGVMQIEVGPADHIFSCGADGTMKMRILPNRF--------- ---SV--AHSNNQ-----------DHLKNSVKFYI >ENSHCOP00000003733 MNLHQVLTGAVNPGDNCFSVGSINNVPFTAYASGCDVVILGSDFERVQIIPGAKHGNIQV GCVDCSLQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGSIVCIFEPVQHPDQK----------DTSLT-------------LNCQW QKTGQFVLQSVVRNLAWHPK---------------------------------------- ------------------------------------GSM-LLTGSTCLQLWSHFDDDAEG GQRAE------------------------------------------------------- ------------------------------------------------------------ -----------IRDCH-CAWKC-----------IW------------------------- --QSKTASPVSLMKFSPDGEFFATAG---------------QDDCLVKVWYSTNKWKSGS FRLFTPSESSVNSQGEIAFSFVYLAHPRSVIGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------SVCNVL LTSCKDSVCRLWAETLLPGNTLLSG----------------------------------- -------------------------HH--------------------------------- ------------------------------------------------------------ ---------------------------------------GN------------------- ------------------------QQSDIQRSASSSRICNGRSQAGTLQEVSNNI----- ------------------KPP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------FYPDAP---------------------------------------- ----------------------------------------------QPSHTGGLSHNQSR -HYNHKKS---SSNLP-HANALCHFHIAASINPATDIPLLPSISSLSAGEDAEPGGLFTV HWLNNKELHFTLAMEVFLQQFR-------------------------------------- ------------------------------------------------------------ ---------------------NSNNEENSEDEVT-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SRPSGPQGPDVAE ---------------------------------------------------------LPL AAMEHQVDVLLDEWNKGADMLFSIHPTDGSLLVWNVDWLDEYHPRMFRQAQVSFVSRIPV AFPAGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GNTLPQTK SALISYGRQVKV-----------AP--------------------------CSSLRLSIF TPNVLMISKHDDGSLNQWGVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPEVDSILALPEVFSG------------------------------------ --------------------------------------------SHGSRPSRLSLGSVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GAY CNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIVSQQSTAKPGCIIELDAVTD--------------------F------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------VSIHCCILGEISINRVEEENKFSQ----------------- -------------------------------NKP-------------------------- -------------TFAASFFLVVVELTPSGQSLLQMW----------------------- --------------------------------HLHLAAKPV--------T---------- --------MG-----------------------------MSASI---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------NHSQFNFDPFS------------------SPIIQ K-----------------SKPCTSNLQSACRLGLTTQRLYSQELPLPAGVEAISVTPSAG HLSASCSLPAGRVPYLIATSCSDGKVRFWRCNAMASETCGNA------------------ --K------LVYQWEEWPLLVEERLPNCSAVSVPGRPVQVSCCHAGRMAVAY-------- ---------RQT------------------------------------------------ ------------------------------------------------------------ ----------------------------TARDQL-----------------------VY- --------------------------IGIFQCESTGGSQWILEQTIVLD----------- ------------------------------------------------------------ ----KTDPNST--------------------------TSP-------------------- ------------------------------------------------------------ ---------------------------DLT------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---LPNEHCLGSTHKSLVHLDWVSQEDGSHVLTVGIGTKIYMFGRLSGKPPELCLTSDGS RDQS----LSRLVVLRSVDLISSVEGSPPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APPKPNAAIPQDTDICSSVSSIVSAVRQSQEDGLTLGPPTSLLA--------------- -----------------------------------P------------------------ -------------------PKKALTRSMMSLAQKLS---GKRTV-YDLPLEMEDSGLFEA AHQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEIVPLKDNT-T-------- ---NPEKRIRSRTIS---AGGSTARERKMFGK-DENSTPDYTEISSIPPLPLYALLAAD- EDTPPKP----------------------------------------------------- -------GQYSLCGNLFIIA---------------------------------------D --------------------LDPLGQDEQEETGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQILS SHLLHSSLPGLTRMEQMSLMALADTIATTSTDLKDSQDHSKGGETLDDCGLKFLLAVRLH TFLSTSLPPAHRAQLLRQG-------------LSTCHYAWAFHSEAEEELLHMLPALHQG EPTWPELRSMGVGWWLRSPNKLRRCIEKVAKATFQRSNDPLDVAIFYLAMKKKALVWGLY RSQKNAKMTEFFRNNFSEDRWRKAALKNAFSLLGKQRFHHSAAFFLLAGSLKDAVEVCLE KLQDLQLALVISRLYESEFETASTYKKILQR------------HVLGHDKQS-------- ---------------------LCTFQ--------IPMHPDPFLRSMAHWVLEDYSKALDT LLEQ-------------------------------------------------------- ------------------------------------------------------------ -TP------SKAKSGSSSASSSNAEVFNFYTFLCTHPLLLRRHFGSSD---KAKVG---- ------LTAEGRRADSISLDERRLFFTAAYAHLQAGCPMLALEVLSKMPKVRKSSKL--- ---------------NQESP---------------------------------------- ------------------------------------------------------------ -----------------------------------------------E-LSAGSKNGPTS DQDWSEPALNGYESGGG---SLS-----NSRSDSVLSFDWSQPSLTHPDEPLELKWDSDR DD---KD-DDNDDEEE-SKSGKSGRTVHNSN----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VFHDMRDSMLP ATETVI-----------------------------------------------SEDSEEG GDF-------------------------------------IHPP---------------- --------------D--------------------------------------------- --------DVFAAQLKFTACLKILTNELRTLSTGYELDGGKLRYQLYQWLERE------- ---------------------VIFKMFIFALTPQMILKHFGEDSYL-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PAS--------------------------------------------- ----------------PSTDR--------------------------------------- ---------------------------Q-----------------------------RS- ---------RRHWLKSN----QPLLRMFLSYCSLYGSHGGGLASVRMELILLLQESH--- ---------------------QV------------------IAIYP-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -HTSFPLLMACTANVKTVVANPIVYLTNLTHDILQTINALNSPPHPDIVNNEIYVMHTLA ASLSACIYQCL----CDGH-Y-------------------------------------S- --HMNNFTGMVYQ--------------SVLLSQKQQARVPSTDGSIQPNTSPAQWPG--- -----IASMIRLLS-SAGDESQPGLAVLLCEILTAVYLSLFAHGMATHSSNELFRIMAHP LSSNLWVTVFGGGARTP------------------------------------VIEKASS PAKTPP------------------------------------------------------ ------------------------------------------------------------ --------------GSKEESSTE------------------KEPPSSPK---PEPVVD-- --------------------------------HEAASIFKECFVPPELSIWDYFIAKPFL PPSENRVQYDSEESQGSE-D--E-E----EDE-----D-DYDNIFDPNSPQKEHTNYNSY SWCLMRLAMVQLVLVNLKSFYPMAGYDLLDLPGASPLCHSVLKTLQRWEQVLQKRLELFG GPPSKYITTQFQEEAVTPGPALLKHKALFEPSNTPF--SRHSALPVKRLWQFLVKQDEVQ ETFIKNIFTKKHDA---------------------GE-------------------TESD LGCPGGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILATQILTWIDDE- EVEAKG-VGTDDFLVIHAHDDFVTLHGTTPYTRSSPGTPINMPWLGGHQTGRGAS----V MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNHQ GNKFGIVDADGGLSLWQTNTSGAAPKPYL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPINSLVH--------------------AFCCHESGATVLLMAPRQQLL ITGGRKGWISVLELPHRHQRQSFQAHDSPVKALAVDPTEDCFISGSAEGSLKVWNLATQC LLYCFPNEHARQSLFRNLGTGVMQVEVGPANHVFSCGADGTMKMRILPNRF--------- ---S------HHH-----------GNFKSDVKFIL >ENSCSEP00000028882 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MKFSLDGEFFATAG---------------QDDCLVKVWYSPSKWKFSI PRVFTPQDPNPSVQGKLSFSFVYLAHPRSVTGFSWRKTSMYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWSETLLPGDTLVSK----------------------------------- -------------------------AH--------------------------------- ------------------------------------------------------------ ---------------------------------------NNRASGQHS------------ --------------------------------------------AG-------------- --------------------P---------------------GKK--------------- ------------------------------------------------------------ --------------------------------------------------HTCNG----- ------------------------------------------------------------ -----RMSGFAL---------------------------------------GWLPQHQSR -HYKHRKS---SSNLP-HAIGLCHFHIAASINPVTDIPLLPSISSLSTADDEEPGGPFTV HWLNNKELHFTLAMDVFLQQLRRSLEQ--------------------------------- ------------QMECSHE----------------------------------------- ------------------------------------E----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SEDEDSF-EEDVASRPCDHQGPERME ---------------------------------------------------------LTL AAVQHQVDVLLEEWNKGADMLFSIHPMDGSLLVWNVDWLDEYQPGMFRQAQVSFVSRIPV AFPAGDAISLSHSVVMYACNKNVDLAIQHGRQ----RPP-------------GTTLPQTK SALISYRGQGKV-----------MP--------------------------SNSLRLSIF TPNVLMISKHADGSLNQWAVSFAEDSAFSTVLSVSHKSRYCGHRFHLNDLACHSLLPLLL TTSHHN-------------------------ALR-------------------------- --------TPDAD-ILAPPEAYYS------------------SF---------------- ------------------------------------------SVSRGSRASRASLGVVSQ DPNAIYSELILWRVDPVGPLSLSGGVSELARINSLHASAFANVAWLPTLIPSSCL--GVY CNSPSACFVASDGHSLRLYQAVIEAKKLLSELSNPEISK--------------------Y VGEVFNIISQQSTAKPGCIIELDAITD--------------------F------------ ------------------QGKETQLLHVFEENLILG------------------------ --------------------------------------NQ-------------------- ----------------------------------------------RAESSQDPPDSPHT -------------------------------GEQ-------------------------- -------------PFSARFFLVVVELTHKGRSLLHMW----------------------- --------------------------------HLHLAACPV--------T---------- --------M--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------E-----------APFNSSPF-------------DMLTFI-----SPVTQ T-----------------SKTCTSNLQSACRLSLSTRLLYSQEMLLPEGVEIINVTPSAG HLSASCSLPAGCVPYLIATSCSDGIVRFWRCNVVAME----------------------- ---PFSMDSLLYQWEEWPFLVDERLPSSSAVNVPGRPIEVSCCHAGRFAV---------- ---------------------------NSLNISQCPDQ---------------------- ------------------------------------------------------------ ---------------------------------------------------------VY- --------------------------IAIFQSESTGGSQWVLEQTIVLD----------- ------------------------------------------------------------ ----SIDATAHY------------------------------------------------ ------------------------------DSDSESSMGQGASVQNNR------------ ---------------------------DLS---------------------LPNLV---- ------------------------------------------------------------ ------------------------------------------------------------ -------NCLGSTSRSLVHLDWVSEEDGSHVLTVGIGTKIYMYGRLTGKPPELGLSSDAA KEQR----LSRLVLLRSVDLVSSVEGSLPIPVSLSWVRDGILVVGMDSEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -KPQRPGAALGQDTDISSSVSSITSAVRQSQDDGPTTG---PLLA--------------- -----------------------------------P------------------------ -------------------PKKGMTRSMMSLAQKLS---GKKTA-YDLPIEMEDFGLFEA AQQLFPTLPQYHPVQLLELMDLGKVHRAKAILSHLVKCIAGEVVTLKDNN-T-------- ---NPEKRVRSRTIG---AGGSTARDPMMFNL-TESSTPGYTEISSIPPLPLYALLAAD- DDTSAKH-----DKV-----------SSVSGD-----------------SGHGST----- ------------------------------------------HTDAYDELFH--TPSIMD --------------------VDPL-NHDKEEAGN-------------------------- --------------------------------------KVIDLSQYSPTYFGPEHAQVLS SHLLHSSLPGLTRLEQMSLMALADTIATTSTDLKVSQDKSKGGETLDECGLKFLLAVRLH TFLSTSLPTAHRAQLLRQG-------------LSTCHYAWAFHSESEEELLNMLPSLQKN DPTWPELRSMGVGWWLRSTNKLRRCIEKVAKTSFQRSNDPLDAAIFYLALKKKAVVWGLY RSQKNTKMTDFFHNNFTEDRWRKAALKNAFSLLGKRRFQHSAAFFLLAGSLKDAVEVCIE KLQDLQLALVISRLYESEYEMGTTYKRILQR------------HILGRDKQN-------- ---------------------LCMFQ--------ISAHQDPFLRSMAYWVLEDYSKALDT LLEH---------GTK---S---------------------------------------- -------------SSFM-----------------------------------------AT CNP---------------------DVFNFYTYLRTHPLLLRRHFGSSD---KGKVG---- ------LTAEGRRADSISLEERRLFFTAAYAHLQAGCPMLALEILSKMPKVCRHSKLP-- ------------------------------------------------------------ TREVQGNSPKHSV----------------------------------------------- -----------------------------------------------E-----SKEGQTS DPDWSQPSLNGYESDGN---SF-------SKSESVLSFDWSQPSLALPDEPLELKWDSDK EN---ND-DD-----------------------EE------------------------- ------------------------------------------------------------ -----------------------------------------------GDRGIKNAQTSGM ADNVS------------------------------------------------------- -------------------------------------------------VFHDTQDTMSP MMDIMT-----------------------------------------------EEDTEDS SDF-------------------------------------IAPI---------------- --------------D--------------------------------------------- --------DVFVAQLKFAACLKMLTNELRTLSTGYEVDGGKLRYQLYQWLERE------- ---------------------V-------------------------------------- ITLQHCCNYKPCL----------------PDLSVHSDASVFGLEEEEE------------ ------------------------------------------------------------ -----QLMFVSQLGS--------------------------------------------- ----------------PRSDS--------------------------------------- ---------------------------Q-----------------------------RS- ---------GRHWLQSN----QPLLRMFLSYCSLHGSHGGGLASVRMELILLLQESH--- ---------------------QV------------------------------------- ------------------------------------------------------IKTSVT SSAQ-------------------------------------------------------- ------------------------------------------------------------ -PTSIPLLMACTAGVKTVVASPIVYLTNLTHDILETINALDSPPHPDVVNNEIYVMHTLA ASLSACIYQCL----CDKHTY-------------------------------------S- --HVNHFTGIVYQ--------------SVLLSQKQSVRHFSVDELVQPNTSPAQWPG--- -----IASMVRLLS-SAGEESQPGLTVLLCEILTAVFLSLFVHGMASHSSPELFRIMAHP LSSKLWVAVFGGGARTP------------------------------------VIEKLNS PARTPP------PGE--------------------------------------------- ------------------------------------------------------------ --------LLSSRSASKEESCHE------------------REGLSSPK---NVTIVD-- --------------------------------QEAPSIFKEQFVPPDLSIWDYFIAKPSL PPSENRIEYDSEENQGSQ-D--E-D----ED--------DYDYMFDPNSPLREHSNHNSY SWCLMRLAMVQLVMVNLKSFYPMAGYDLLDLPVASPLCHAALRTLQRWEQVLQKRLEIFG GPPSKYISTHLHDETTPPGPALLRHKALFEPSNTPFRTTHHSALPVKRLWQFLVKQEEVQ ETFIRNIFTKKNDP---------------------NE-------------------TGSD LGSPVGKARIIHKESDIITAFAINKANRNCLVMASTHDIQELDVSSILSTQVFAWIDDD- EADVKG-VGGDDFLVVRAHDDSANVHGTTPYTHSSLGTPINVPWLGGLQTGRGAS----T MIKRNINNVRRMTSHPTLPYYLTGAQDGSVRMFEWGHSQQIICFRSPGNSRVTRIRFNYQ GNKFGIVDADGALSLWQTNTSGNAPKPYL--TLQCHNKTAHDFVFVGSSSLVATA----- -----------------VYSLFPRELFPSHLTLCSSVSSAFCCHESGATVLAVAQRQQLL ITGGRKGWISVLELAPRHQRKSFQAHDSPIKALAVDVIEDCFISGSAEGTIKVWSLDTQT LLFSFANEHARQSLFRNLGTGVMQIEVGPANHLFSCGADGTLKMRVLPNRF--------- ---SV--I-NNNNNNNNNNNNNQNGNLQNDVKFFI >ENSCHAP00000041119 MNLHQVLTGAVNPGDNCFSVGSLNNVPFTAYASGCDIVILGSDFERLQIIPGAKHGNIQV GCVDCSQQGGQ------------------------------------------------- ------------------------------------------------------------ ------IAASYGNTVCVFEPVPLLNPE-KTQT----------------------RFGYQW QKSGQFVLQSIAHNLAWNPA---------------------------------------- ------------------------------------GMQ-LLTGSSSLQLWSN------- ------------------------------------------------------------ ----------ESPPWGPTEEGPRPSTEG-------------------------------- ---------------H-SSWTC-----------IW------------------------- --QCKTASSIHFLKFSPGGEFFATAG---------------QDDCLVKVWYGTSSWQWDA GKLFTPPE--QSSLGGLDFSFIYLAHPRSVTGFSWRKTSKYMP-R--------------- ---------------------------------------G--------------AVCNVL LTCCKDSVCRLWAETLLPSDCLLSGLKHN------------------------------- -------------------NPGNHQHH--------------------------------- ------------------------------------------------------------ -----GDPNRLARDNKKLPANGRSPNPLE------------------------------- ------------------------------------------------------------ -----------LNLQESW-----------------------------GGSQRGVLAH--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------TSPLPQQQGK -HYSHKPTQA-------HANALCHFHIAASINPATDIPLLPSISSLNGTDEEEPGGPFTV HWLNNKELQFTLAMEVLLQMLRSA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------Q-------------------------------------------- ------------------------------------------------------------ -------------------DNSPSGVNTTDNSGTAGTEHTHTHTHTLTHTHTHTEAGMDV VAMEQQVELLLEDWNSSADMLYSIHPTDGSLLVWHVDWLDEYQPGMFRQAQVSFVSRIPV AFPTGDANSLSRSVVMYACNKNVDLAIQQGRQQQQ-RPS-------------GGGLPR-- -----------------------SPSLISCYGLGKPTSCSSSSG-------SVGLRLSIF TPSVLMISKHADGSLNQWTVSFGEDSAFSTVLSVSHRSRYCGHRFHLNHLACHSLLPLLL TTSHHN-------------------------ALRPQQPANAAAAATATLRPAPAPVPAHP SRGSSLSAPP-------------------------------------------------- -----------------------------------------------------------Q DANAVYSELILWRVEPVGPLSFSGGVSELARINSLHASAFANVAWLPALIPSNCL--GQY GSSPSACFVANDGHSLRLYQAVIEAKKLLSEVSNPDNSK--------------------S VGEAFNIISQQSTARPGCIIELDGITD--------------------FVR---------- ------------------------------------------------------------ -------------------------------------------------------NDSDS LDLTQKRLHTTLENAC-------------------------------------------- -------------------------------GQP-------------------------- -------------VFSARFFLVVMEAMPTGRSLLHMWLLTSFVSLLFCNSWLSVSGGVST GVGRDQSGSGSSSEMSGCPAGPQRSGSIPCGLH--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SACRLALHSTRVFSQELELPSGVEVITVTPAAG HLSSSSLQPAGRAPYLLATSCSDGQVRFWRCGLV---------PEPQPESQS-------- ----------AYEWEEWPLSVEEGSANSSAISIPSKPSAVCCCHTSRVAVAY-------- ---------R-------------------------------------------------- ------------------------------------------------------------ -------------------------------EPG-----------------------GH- --------------QEVRAKDAPPLLVSIFQCESTGGSQWVLEQTLQLD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------AP-----------------------------T---------------------- -------------------------------------EGAWEGSLSAGPDEGKQGGAEEC QF----------SGRSAVHLDWVSREDGSHVLTVGVGSRLHMYGSLLVKPPELGL-FDGG RDGR--RDASRLVLLRAVDLVSSVEGSLPIPVSLSWVRDGILVVGMDCEMHVYSQWQPP- ------------------------------------------------------------ ------------------------------------------------------------ -APAR-------------------------------------------------SASVSR GTDSGSVSSLVATLKQDGHTPS-------------P------------------------ ----------------VT-SRKPLTRSLNSVAQKLNAGGGKRCAGLELSAQLEDSGLFEA AHQLSPTLPQYHPVQLLELMDLGRVQRAKAILSHLVKCVAGEVVVLK----GDGGSGGGG GS-----RLRSRTFSGGGGGGSTARDAKLFQR-PE-ATSDYTEIESIPPLPLYALLAAD- HDSS--------------------------------GITKDEPASVGPDSGKGSS---PR SDPPST----------------------------------------YDQLFQ-------- -SSGVPSGADEPPDLFR--------DDEEDEEKA-------------------------- --------------------------------------KVIDLSQYGPTAFGPEHAQVLS SHLQQASLPGLTRMEQMSLMALADTVASTRTDLGEGQGESQGGETLDECGLRFLLAVRLH TFLLTSLPPAHRAQLLHQG-------------LSTSHYAWAFHSEAEEELLNMLPALQKG DPAWPELRAMGLGWWLRSTPRLRRCIEKVAKATFQRNNDPLDAALFYLAMKKKAVVWGLY RSQRNTKMTEFFSHNFNEDRWRRAALKNAFSLLGKQRFQHSAAFFLLAGSLKDAVEVCIE NLQDLQLALVITRLYESEFESSSSYKRILQR------------HVLGHDPH--------- ----------------------------------LPPHADPFLRSMACWVLDRYSRALDT LLEQ---------PT--------------------------------------------- ------------------------------------------------------------ --PAVDQSQS--------------KVFNFYTYLRTHPLLLRRHLGSRE---R-RGG---- ------LSTEGREEDSVTLVERRLFFTAAYSHLQAGCPLLALEVLSRLPRTIK------- -------------------P---------------------------------------- -----------------GGP---------PGPDSPAHTPTSGAELSS------------- ----------------------------------------------------------VA EPDWSQPLFNGFGSACDTPSSAN-----HSRSDSALSLDWSQPSVSMVDEPLDLKWDKD- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NKQADMDVKKVDEAPD------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------PS---------------- -----SPGTFP---D-----------------------P--SSASSPAHPSSSSEAVSSP GPEAPAGVDIQAAQLKFRACLKLLTSELRTLASGGPLDGGRLRHQLAVWLQRE------- ---------------------V-------------------------------------- EALERCCGYSPCA----------------P------------------------------ ---------------------------IPEGLQGDGDSHLSLSPVAETLSGGVESGRAGA EA---------------------------------------------------------- ------------------------------------------------------------ ---------------------------QG------------------------------- ---------RRQWLQRN----QQLLRIFLSYCSLHGSHGGGLASVHMELILLLQESQ--- ---------------------Q-------------------------------------- ---------------------------------------------------DESV----- -------------CPGGVSP-------QP------------------------------- ------------------------------------------------------------ -PATIPLLLSCMGCSRTVVANPVSHLTSLTHDILRTINALDSPPHPD----SIYVMHALA ASLSSCVYQCL----CDGHPY-------------------------------------S- --QVNGLMGTVYQ--------------SALHSQHAPGRGVSTEETFLPNTPPAQWPG--- -----VGALVRLLSVCGGDEGRTGLGVLLCEVLTAVFLSLFVHGLATHSSAQLFRVLAHP LNSKLWFAVFGGGARLPTSKVEGREKYLGVSWSMAVAHE--------------------- -------------------------------------------------GA--------- ------------------------------------------------------------ ERKPKRFRLLSSRSGSR------------------GEAP--PESPPSPR----------- SPPSEPHPSSVT----------------------------ERFVPPELSIWDYFIAKPFL LPSESRFEYDSEESLGSE-D---------DDE-----D-EYSDAFDSSSPQREHSNPNSY SWCLMRLAMVQMVLANLRSFYPMAGHDLMDLPVGSPLCHAVLKTLQRWEQVLLKRLEIFG GPPPKYISTHTNDDSSTPGPALLRHKALFEPSNTPFRSQQHAALPVRRLWQYLVKQEEVQ ETFIRNIFTKKRDQNESFEDCRDYGKCSGTEEANPNQ-------------------IEAD LGYPGGKARIIHKESDIITAFAINKANRNCLVIASTHDIQELDVSAILATQILTWIDDEA ENETK---GGDEFLVVHARDDFATLHGTTPYTHSSPGTPINLPWLGSMQTGRGAA----V LIKRNINNVRRMASHPTLPYYLTGAQDGSVRMFEWGHSQQITCFRSPGNSRVTRIRFNYQ GNKFGIVDADGALSLWQTNTTGNTHKPFL--TLQCHNKTAHDFVFVGSSSLIATAGLSTD NRNVCLWDTLVTPANSLVH--------------------AFSCHETGATVLAISPKQQLL LAGGRRGWISVLDLTQRLQRQSFQAHDSPVKALAVEPAEACFISGSAEGNIKVWSLLTQT LLHSFPNEHARQSLFRNLGTGVMQIEAAPAHQVFSCGADGTMKLRVLPDRL--------- ---SV-----------------QASRARNNVKFII