>ENSLBEP00000021558 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVVPYTLPGVLALI-GWWWYISRKKDRLIGHDGPE-GAPAAMG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------AS- ------TEGSN-------------------------GLVEKGTESP-TNDTVSSAH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------IP- ------------------------------------------------------------ -TQ--------------GGNP--------RT-------------HVS------------- ----------------------SEVAP--------------------------ICEDA-- ---------------------------APHL----------------D------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------RVPPLSAQTSPGKEEELQLSLKEQKEPERS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------SL-------------------------------------- ------------------------------------------------------------ --------------------------------SEP------------------------- EPAAEEAIVS-------------------------------------------------- -------------------------------------------S---------------- --------------QSTK---V-------------------------------------- ------SSSSS------------------------------------------------- ---------------------------------------LSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVSKHHSTVNAQEEMLV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ TL---------------------------------------------------TPA---- ----------------------------------------------------------RV -QRVTPSEADSLETPPSAQDFHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HVLT-------------------------------------------- ---------------------------------STPA----------------------- ----------------------------------------------------FPST---- -----------------SLASTSLNAIQDSSA---------------------------- ------------------------HLSETTQDDQEP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -DLELLAAGLITEVISAATQEV-------------------------------------- --------------------------LGVTSSQVD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------SGRLCS------------------------------------------- ------------------------------------------------------------ ---------------------QHEP----------------------------------- -IKAEQLHLLTS-----------------------PSQSNKEGMSNGISSAAG------- -----------------------------WEPAELRSHQTLG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AQRGHWP--------------------AAQSSS ---------------------------LLN------------------------------ K----------------------------------------------------------- ------------------------------------------------------LRG-DE AVAL------------------------------AEDSA---CSTCHSEDGVS--SE--D L-------HNSMFDNHTDIIQVTDLS---------------------------------- ----------------------------------------------------VRETSQTP ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLVESAAEETIQAEGDDISVDAAGDI KRLNGMGLRNGAHGACE-ETDQSG----GSDVNSMDSVDSG-CTMGLSDSQ----SNHTA SASSELIIWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQEFQICHVEGT QQQVDKALSLIGKKFKDLDLTNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVEG-AWWRAQVITFYKETNEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSADATSALEEMTRGAALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNMVGEEV------------------------------ -----------------------------ISVNRTLAERGLG-VWVDAF----------- ------------------------------------------------------------ - >ENSSPAP00000006668 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVMSYTLPGVLALI-GWWWYISRKKEQLISHDSPD-GPPTAMG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------SS- ------AEGSN-------------------------GLVERGTVSP-TNESESPIPRTP- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------TVSNQR-THHE--------- -NISQTHVQDTKATQSLEPRSEEGAPHLGKIGREKVYK---------------------- ----------------------------------------------------------PS D--------------------------------------------------STLPTRDKE DS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP--------------VSLKGHKDPERSSS------------ ------------------------------------------------------------ ---------------------------ELEKHPVKN-------LVG---------TL--- -----------EAT---------------------------------------------- ----------VD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ELILPCQSTK---V-------------------------------------- ------------------------------------------------------------ ------------------------------TSSSPTTAYLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAKYHSTINAQNEMVV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ AL---------------------------------------------------TPA---- ----------------------------------------------------------KV -QNLIPSEADSLETPPSAQDLQQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HILT-------------------------------------------- ---------------------------------STPTAMDLTSTA---------LTTVQD STITSVTSQD-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------VQAHIST-------- ------------------------------------------------GEE--------- ------------------------------------------------------------ QDLELLAAGLITEVISAATQEV-------------------------------------- --------------------------LGVTSCQVT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NNSQPSC----------------------------------------- S----------------------------------------------------------- -----SSM----------------------------------------------L----- ---------LTSSRVC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LQ----QD--------------------------------------- ------------------------------------------------------------ ----------------PVTVKQQHHHLLTSPSQVGCECKEATETEE---------QGVPN GCS-----------------------------------------SATVWA---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------PVEVSHRVHQGNNAQRGHWPTPSH---------------QAAQNIP ---------------------------VLN-----------------------------I K----------------------------------------------------------- ------------------------------------------------------LKC-EE PATL------------------------------AEDSA---CSTCHSEDGVS--SE--D L-------QNSMFDNQIDVIQVTDLS---------------------------------- ----------------------------------------------------ASEATQPQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLVETITE-TVLDVTEDNSVAAVCEI KRLNGMGLRNGAHGTCEVETDQSG----GSDVNSMDSVDSG-CTMGAGENQ----SNHAA SSSSELIIWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQEFQICHIEGT QQQVDKALSLIGKKFKDLDLTNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVEG-AWWRAQVITFYKETKEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSAEATSALEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNMVGEEV------------------------------ -----------------------------ISVNRTLAERGLG-VWVDGF----------- ------------------------------------------------------------ - >ENSAPOP00000012893 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVMSYTLPGVLALI-GWWWYISRKKERLISHDSPE-GPPNVLG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------SS- ------TEGSN-------------------------GLVEKGTMPT-TNDTESPAPRPP- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------EFSNQR-TEQG--------- -NISQTHVQDTKATLSLEQRSEEGAPHLGRIRQEKVYK---------------------- ----------------------------------------------------------PS D--------------------------------------------------STLPTCDKD DS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP--------------VSLKGHKEPERSSSPDL--------- ------------------------------------------------------------ -------------------------VAELEKHP--------------------------- ------------------------------------------------------------ -----------DKKSGAAPEVT-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------V------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------EELILPCQSTK---L-------------------------------------- ------------------------------------------------------------ ------------------------------ISSSPTTAYLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAKHHSTINTQNEMVV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ AL---------------------------------------------------APA---- ----------------------------------------------------------RV -QSVVPSEADSPETPPSAQDLHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HIVT-------------------------------------------- ---------------------------------STPTTITSASTA---------LTTIQD STITSVTSQD-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------ILAYNYT-------- ------------------------------------------------EED--------- ------------------------------------------------------------ QDLELLAAGLITDVISAATQEV-------------------------------------- --------------------------LGVTSCKIT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NNSQPSC----------------------------------------- N----------------------------------------------------------- -----SSV----------------------------------------------L----- ---------LTGSGVC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------FQ----QD--------------------------------------- ------------------------------------------------------------ ----------------PVTVKQQHHHLLTSSSQVGCEYKDASEKEE---------QGVPN GCS-----------------------------------------SAPVWE---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------PIEVSHRVRQTYNPQRGHWATASQ---------------QSAQSIP ---------------------------VLN-----------------------------I K----------------------------------------------------------- ------------------------------------------------------LKS-DE STTL------------------------------AEDSA---CSTCHSEDGII--SE--D H-------HSSMFDNQIEEIQVTDLS---------------------------------- ----------------------------------------------------AREATQPQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLVENIAEVTVLGETEDHTVATVCEI KRLNGMGLRNGAHGTCEVETDQSG----GSDVNSMDSVDSG-CTMGAGENQ----SNHTA SSSSELIIWEVEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQEFQICHIEGT QQQVDKALSLIGKKFKDLDLTNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVEG-AWWRAQVITFYKETKEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSAEATSALEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNMVGDEV------------------------------ -----------------------------ISVNRTLAERGLG-VWVDGF----------- ------------------------------------------------------------ - >ENSAPEP00000010072 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVMSYTLPGVLALI-GWWWYISRKKERLISHDSPE-GPLTAMG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------SS- ------TEGSN-------------------------GLVEKGTMPT-TNDTESPAPRLP- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KVSNQR-TEQG--------- -NISQTHVQDTKATPSLEQRSEEGAPHLGRIRLEKVYK---------------------- ----------------------------------------------------------PS D--------------------------------------------------STLPTCDKD GS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP--------------VSLKGHKEPERSSSPDL--------- ------------------------------------------------------------ -------------------------VTELEKRL--------------------------- ------------------------------------------------------------ -----------DKKSAAAPEVT-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------I------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------EELILPCQSTK---I-------------------------------------- ------------------------------------------------------------ ------------------------------TSSSPTTAYLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAKHHSTINTQNEMVV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ AL---------------------------------------------------TPA---- ----------------------------------------------------------RV -QSVIPSEAESPETPPSAQDLHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HIAT-------------------------------------------- ---------------------------------STPTAIALTSTA---------LTTIQD STITSVTSQD-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------ILAHNNT-------- ------------------------------------------------EEE--------- ------------------------------------------------------------ QDLELLAAGLITDVISAAAQEV-------------------------------------- --------------------------LGVTRCQIT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NNSQPSC----------------------------------------- N----------------------------------------------------------- -----SSM----------------------------------------------L----- ---------LTGSSVC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------FQ----QD--------------------------------------- ------------------------------------------------------------ ----------------PVTVKQQHHHLLTSSSQVGCECKDASDKEE---------QGVPN GCS-----------------------------------------SAPVWE---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------PIEVSHRVHQTYNPQRGHWPTPSQ---------------QSAQSVP ---------------------------VLN-----------------------------I K----------------------------------------------------------- ------------------------------------------------------LKC-DE PTTL------------------------------TEDSA---CSTCHSEDGII--SE--D H-------HNSMFDNQVDEIQVTDLS---------------------------------- ----------------------------------------------------AREATQPQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLVENITEVTVLGETEDHTVATVCEI KRLNGMGLRNGAHGTCEVETDQSG----GSDVNSMDSVDSG-CTMGAGENQ----SNHTA SSSSELIIWEVEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQEFQICHIEGT QQQVDKALSLIGKKFKDLDLTNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVEG-AWWRAQVITFYKETKEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSAEATSALEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNMVGDEV------------------------------ -----------------------------ISVNRTLAERGLG-VWVDGF----------- ------------------------------------------------------------ - >ENSAOCP00000026507 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVMSYTLPGVLALI-GWWWYISRKKERLISHDSPE-GPLTAMG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------SS- ------TEGSN-------------------------GLVEKGTTPT-TNDTESPAPRLP- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KVSNQR-TEQG--------- -NISQTHVQDTKATPSLEQRSEEGAPHLGRIRQEKVYK---------------------- ----------------------------------------------------------PS D--------------------------------------------------STLPTSDKD GS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP--------------VSLKGHKEPERSSSPDL--------- ------------------------------------------------------------ -------------------------VTELEKRP--------------------------- ------------------------------------------------------------ -----------DKKSAAAPEVT-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------I------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------EELILPCQSTK---I-------------------------------------- ------------------------------------------------------------ ------------------------------TSSSPTTAYLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAKHHSTINTQNEMVV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ AL---------------------------------------------------TPA---- ----------------------------------------------------------RV -QSVIPSEAESPETPPSAQNLHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HIAT-------------------------------------------- ---------------------------------STPTAIALTSTA---------LTTIQD STITSVTSQD-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------ILAHNNT-------- ------------------------------------------------EEE--------- ------------------------------------------------------------ QDLELLAAGLITDVISAAAQEV-------------------------------------- --------------------------LGVTRCQIT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NNSQPSC----------------------------------------- N----------------------------------------------------------- -----SSM----------------------------------------------L----- ---------LTGSSVC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------FQ----QD--------------------------------------- ------------------------------------------------------------ ----------------PVTVKQQHHHLLTSSSQVGCECKDASDKEE---------QGVPN GCS-----------------------------------------SAPVWE---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------PIEVSHRVHQTYNPQRGHWPTPSQ---------------QSAQSVP ---------------------------VLN-----------------------------I K----------------------------------------------------------- ------------------------------------------------------LKC-DE PTTL------------------------------TEDSA---CSTCHSEDGII--SE--D H-------HNSMFDNQVDEIQVTDLS---------------------------------- ----------------------------------------------------AREATQPQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLVENITEVTVLGETEEHTVATVCEI KRLNGMGLRNGAHGTCEVETDQSG----GSDVNSMDSVDSG-CTMGAGENQ----SNHTA SSSSELIIWEVEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQEFQICHIEGT QQQVDKALSLIGKKFKDLDLTNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVEG-AWWRAQVITFYKETKEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSAEATSALEEMTRGAALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNMVGDEV------------------------------ -----------------------------ISVNRTLAERSLG-VWVDGF----------- ------------------------------------------------------------ - >ENSLCAP00010007484 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSFVPYTLPGVLALI-GWWWYISRKRERLISHDSPD-GAQTAMG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KT---------------SP- ------AEGSN-------------------------GLVEKGTVSS-TNDTECPTHRPP- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KVTNQR-TEHE--------- -NNSHIHV---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QGSEASPSLKPTS EEASP--------------------------HLGRTRTEELLKPLVVTLPSPGEEDSPQV SLKHQ-----ND------------------------------------------------ -----------------TEKS--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------S-------------------------------------------------- -------------------------------------------SLALGRELEKHQIKDSA SAPE-ASEEVILPCHSNK------------------------------------------ ------------------------------------------------------------ -------------------------------------DYLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAKHNSTINTQDKIIV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ AV---------------------------------------------------TPA---- ----------------------------------------------------------KL -QSVNPSESDSLETPPTVQDFHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HILT-------------------------------------------- ---------------------------------STPTTLALTSTA---------LTMVQG SLTNSVTPGDMQI----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------HNSS-------- ------------------------------------------------GKE--------- ------------------------------------------------------------ QDLELLAAGLICEVISAATQEV-------------------------------------- --------------------------LGVTRSQIT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DNSQPSC----------------------------------------- S----------------------------------------------------------- -----SST----------------------------------------------P----- ---------PASSRLC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SQ----QE--------------------------------------- ------------------------------------------------------------ ----------------TFTAAQQHHHLLTSSSQISSESPEATEKEW---------EGMPN GCS-----------------------------------------SAPVWE---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------AAEVSHRVCQTHNAQRGHWPTTSH---------------EAAQSIP ---------------------------LLN-----------------------------M K----------------------------------------------------------- ------------------------------------------------------LKV-DE VALL------------------------------AEDSA---CSTCHSEDGIS--SE--D L-------QNSMFNNQRDVIQITDLS---------------------------------- ----------------------------------------------------ARGAAQPQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLVESASEAMVLAATEENSVDAVCEI KRLNGIGLRNGAHGACELETDQSG----GSDVNSMDSVDSG-CTMGAGESQ----SNHAA SLSSELIIWEIEVP-KHLVGRLIGKQGRFVSFLKQNSGAKIYISTLPYTQEFQICHIEGT QQQVDKALSLIGKKFKDLDLTNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFICYSQPGTPALPSPAEV GVICAAPAVEG-AWWRAQVITFYKETNEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSPEATSALEEMARGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNMVGDEV------------------------------ -----------------------------ISVNRTLAERGLG-TWVDGF----------- ------------------------------------------------------------ - >ENSSLDP00000002298 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVVPYTLPGVLALI-GWYWYISRKKERLITHDSPE-GALTPVG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------SP- ------AEGSN-------------------------GLVEKGTVSSPTNDTERPAHRPP- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KVTNQR-TEHE--------- -NISHIHVPDSEAAPSPEQRSEEAAPPLGRTRGEDVHK---------------------- ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PDVAA------------------------------------- ---------PS-----------------------------------PG-----KD----- -----------DSSQVSSKD-----------------------------------HKAPE ESSSLALETEL--------------------EKQQIRDPVPAPEALV------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------EEVIVPCQSNK---V-------------------------------------- ------------------------------------------------------------ ------------------------------SSSSPATAYLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAKHHGTSNTQDELIV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ SV---------------------------------------------------TPA---- ----------------------------------------------------------KV -QRVMPSEADSLETPPSTQDFHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QITST----------------------------------PNTPG----- ------------------------------------------------------------ -----------------------------------P------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TSTALTT------------------- ------------------------------------------------------------ -----------------------------VE---DSINTTATPESIQTHGSS-------- ------------------------------------------------GEE--------- ------------------------------------------------------------ QDLELLAAGLICEVISAATQEV-------------------------------------- --------------------------LGVTRCQVT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DNSEPTCS---------------------------------------- S----------------------------------------------------------- -----SST----------------------------------------------P----- ---------LASSRLC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SQ----QE--------------------------------------- ------------------------------------------------------------ ----------------AITAAQQRHHLLTSSSQTSCESREATEKEQ---------QGVPN GCS-----------------------------------------SAPVWE---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------PVEVSQRAHQTNNAQRGHWPTASH---------------EAAPSVP ---------------------------LLN-----------------------------A K----------------------------------------------------------- ------------------------------------------------------LKG-DE GAVP------------------------------AEDSA---CSTCHSEDGIS--SE--D L-------QNSMFDNQMDVIQITDLS---------------------------------- ----------------------------------------------------AKEAALPQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLVETAAEATVSSVTEENSVDSVCEI KGLNGMGLRNGAHGTFE-ETDQSG----GSDVNSMDSVDSG-CTMGVGESQ----SNNAA SLSSELIIWEIEVP-KHLVGRLIGKQGRFVSFLKQNSGAKIYISTLPYTQEFQICHIEGT QQQVDKALSLIGKKFKDLDLTNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVEG-AWWRAQVITFYKETNEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSPEATSALEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNMVGEEV------------------------------ -----------------------------ISVNRTLAERGLG-SWVDGF----------- ------------------------------------------------------------ - >ENSSDUP00000026777 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVVPYTLPGVLALI-GWYWYISRKKERLITHDSPE-GAPTPVG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RS---------------SP- ------AEGSN-------------------------GLVEKGTVSSPTNDTERPAHRPP- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KVTNQR-TEHE--------- -NISHIHVPDSEAAPSPEQRSEEAAPPLGRTRGEDVHK---------------------- ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PDVAA------------------------------------- ---------PS-----------------------------------PG-----KD----- -----------DSSQVSSKD-----------------------------------HKAPE ESSSLALETEL--------------------EKHQIKDPVPAPEALV------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------EEVIVPCQSNK---V-------------------------------------- ------------------------------------------------------------ ------------------------------SSSSPATAYLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAKHHGTSNTQDELIV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ AV---------------------------------------------------TPA---- ----------------------------------------------------------KV -QRVMPSEADSLETPPSTQDFHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QMTST----------------------------------PNTPG----- ------------------------------------------------------------ -----------------------------------P------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TSTALTT------------------- ------------------------------------------------------------ -----------------------------VE---DSTTTTATPESIQTHGSS-------- ------------------------------------------------GEE--------- ------------------------------------------------------------ QDLELLAAGLICEVISAATQEV-------------------------------------- --------------------------LGVTRCQVT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DNSQPAC----------------------------------------- S----------------------------------------------------------- -----SST----------------------------------------------P----- ---------LASSRLC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SQ----QE--------------------------------------- ------------------------------------------------------------ ----------------AITAAQQHHHLLTSSSQTSCESREATEKEQ---------QGVPN GCS-----------------------------------------SAPVWE---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------PVEVSQRAHQTNNAQRGHWPTASH---------------EAAPSVP ---------------------------LLN-----------------------------A K----------------------------------------------------------- ------------------------------------------------------LKG-DE GAVP------------------------------AEDSA---CSTCHSEDGIS--SE--D L-------QNSMFDNQMDVIQITDLS---------------------------------- ----------------------------------------------------TKEAALPQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLVETAAEATVSSVTEENSVDSVCEI KGLNGMGLRNGAHGTFE-ETDQSG----GSDVNSMDSVDSG-CTMGVGESQ----SNNAA SLSSELIIWEIEVP-KHLVGRLIGKQGRFVSFLKQNSGAKIYISTLPYTQEFQICHIEGT QQQVDKALSLIGKKFKDLDLTNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVEG-AWWRAQVITFYKETNEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSPEATSALEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNMVGEEV------------------------------ -----------------------------ISVNRTLAERGLG-SWVDGF----------- ------------------------------------------------------------ - >ENSMALP00000001202 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVVPYTLPGVLALI-GWWWYISRKKVRLISHDSPE-GAATIMG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------SQ- ------TNGSN-------------------------GLVEKGNISP-INDIESPTHRCP- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KIINQR-TENK--------- -NISQVHVQDAEAAHSLEQSPEEATPHLATVRQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RE---------------ILKPSVSLTSTGKEDNLQVSL KGHNDSEKTSSLVMATMLQKQQIKGL---------------------------------- ----ASA------PEDTMEEVILPWQSIRDTSSSPTTVHLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAKNHITSNTQDERVV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ AV---------------------------------------------------TPA---- ----------------------------------------------------------KV LPSVIPSEVDSLDSPPLVQDYHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HKLT-------------------------------------------- ---------------------------------STPTALALASTA---------LTMVQD SLTRSVPTDDIQL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------HSSS-------- ------------------------------------------------GEE--------- ------------------------------------------------------------ QDLELLAAGLITEVISAATQEV-------------------------------------- --------------------------LGVTSYQIT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DSTQPTC----------------------------------------- S----------------------------------------------------------- -----SST----------------------------------------------L----- ---------LVNGRLC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SQ----HE--------------------------------------- ------------------------------------------------------------ ----------------PSTSAQQHHHLLTNPCKIGYEYREETQREE---------QGMPN GCS-----------------------------------------SAQEWE---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------PVEVSHRIHQTNNEQRHTWPTLSL---------------QAAQNIP ---------------------------LLN-----------------------------M K----------------------------------------------------------- ------------------------------------------------------LKG-DE AVVL------------------------------AEDSA---CSTCQSEDGIS--NE--D L-------QTSIFDNQMDVIQVTDLS---------------------------------- ----------------------------------------------------VREFTQPR ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLVETTTEETVLAINEKSSVDAVCEI KRLNGKGLRNGAHGTCDVEMDRSG----GSDVNSMDSVDSG-CTMGAAES---------- SSNSELIIWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQEFQICHLEGM QQQVDKALSLIGKKFKDLDLTNLYAPPAPP-LT---LPSLPMTSWLGASINIQLRIDSQK LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGAPALPSPAEV GVICAAPAVEG-AWWRAQVITFYKETNEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GDDHFSPEAILALEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SSYDNTTGLPLVHLWNMVGDEV------------------------------ -----------------------------ISVNRMLAERGLG-SWVDGI----------- ------------------------------------------------------------ - >ENSMAMP00000005867 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVVPYTLPGVLALI-GWWWYISRKKVRLISHDSPE-GVPTTVG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------TP- ------AEGSN-------------------------GIVEKGTVSS-ASDTNSLTHRSQ- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KITNLR-TENK--------- -NIPKLHVQHTDAAPTVEQSPEEATPNLASVRQGEVHKIS-------------------- ---------------------------------------------------------VP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PL---SSYGKAESLHVSLKDHKDPEKTSSPVL--------- ------------------------------------------------------------ -------------------------VTKLEKHV--------------------------- ------------------------------------------------------------ -----------VKDSASAIEVA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------TEEVIFPSQSTK---V-------------------------------------- ------------------------------------------------------------ ------------------------------TSSSPTAVHISDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAKHQSTINTQVEKVG--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ AL---------------------------------------------------TPA---- ----------------------------------------------------------KV -QSVISSEVDSLETPPSVQGYYQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------H-IT-------------------------------------------- ---------------------------------STPAALVLTSTA---------LTPVQD TITRSATSEGTQL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------HSRN-------- ------------------------------------------------GEE--------- ------------------------------------------------------------ QDLELLAAGLITEVISAATQEF-------------------------------------- --------------------------LGVTSYQIS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DNNQPTC----------------------------------------- S----------------------------------------------------------- -----GST----------------------------------------------K----- ---------LVSSRQC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SQ----QE--------------------------------------- ------------------------------------------------------------ ----------------SSTAVQQHQHLLTGSSQIGYESRGATQIEG---------QGMPN GYS-----------------------------------------SAPEWD---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------PFEFSHRVHQTKNAQKDPWPMPPH---------------QSAQSIP ---------------------------LLS-----------------------------M K----------------------------------------------------------- ------------------------------------------------------LKG-GE ALML------------------------------AEDSA---CSTCHSEDGIS--SE--E L-------QTSMFDNQMDVIQVTDLS---------------------------------- ----------------------------------------------------ARKDTHPQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PLVESTKKETVLALPEENSVDVVCE- KSFNGMCLKNGAHGTCEVETDQSG----GSDVNSMDSVDSG-CTMGAAESQ----SKHVV SSNSELIIWEIEVP-KHLVGRLIGKQGRYVGFLKQNSGAKIYVSTLPYTQEFQICHIEGT QQQVDKALSLIGNKFKDLDLTNLYAPPAPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVEG-GWWRAQVITFYKETNEVEIRYVDYGGYDRVKIESLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSPEATSLLEEMTRGMALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNMVGDEV------------------------------ -----------------------------ISVNRTLAERGLG-SWVDGF----------- ------------------------------------------------------------ - >ENSONIP00000018669 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVVPYTLPGVLALI-GWWWYISRKRERLINHDRTE-GTPTTTD----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KT---------------SS- ------ADGSN-------------------------GLVEKDTVSP-TNDTDSPIHRPP- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KASNQR-TQHE--------- -NISQISFQHTEASPSLAQSSE-----------------EFSC----------------- -----------------------------------------NSERMKQGVHRPPQSALP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SLDKDDSLQVSS---KDPERS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --LSLALGTELNLVKDPVSDLEQATSEKITFS---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------YQSTK---V-------------------------------------- ------------------------------------------------------------ ------------------------------TSSFPTTSLLSGAERPD-----------P- ------------------------------------------------------------ -----E---------GEVAKNHSTNNTQDEMVG--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ ML---------------------------------------------------IPA---- ----------------------------------------------------------NV -ESVDPSEADSLDSIPPVQDFHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HILS-------------------------------------------- ---------------------------------STPTAPVLASTS---------LSIVQ- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------NTTAVTPEDILVYGSP-------- ------------------------------------------------GEE--------- ------------------------------------------------------------ HDLENLAAQLITKVISAATQEV-------------------------------------- --------------------------LSVTSCQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------N-----------------------------I K----------------------------------------------------------- ------------------------------------------------------QKG-DD AAPL------------------------------AEDSA---CSTCHSEDGIS--SE--D L-------QSSMFDNQSDVIQLTDIS---------------------------------- ----------------------------------------------------AREAAQGQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VQTESLTEGLVLSATEEDSLDAACEI KGLNAVGVRNGAHGTCEVETDQSG----GSDVNSMDSVDSG-CTMGALESK----GNHAA SSSTELIIWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQEFQICHIEGT QQQVDKALSLIGKKFKDLDLNNLYAAPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEI GVICAAPAVEG-AWWRAQVITFYKESNEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSAEATSELEEMTRGVPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SSYDNNTGLPLVHLWNMVGDEI------------------------------ -----------------------------ISVNRTLAERGLG-VWVDGF----------- ------------------------------------------------------------ - >ENSMZEP00005000686 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVVPYTLPGVLALI-GWWWYISRKRERLINHDRTE-GTPTTTD----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KT---------------SS- ------ADGSN-------------------------GLVEKDTVSP-TNDTDSPIHRPP- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------NASNQR-TQHE--------- -NISQIHFQHTEASPSLAQSSE-----------------KFSC----------------- -----------------------------------------NSERMKQGVHRPPQSALP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SLDKDDSLQVSSKDRKDPERS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --LSLALGTELNLVKDPVSDLERA-----TFS---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------YQSTK---V-------------------------------------- ------------------------------------------------------------ ------------------------------TSSFPTTSLLSGAERPD-----------P- ------------------------------------------------------------ -----E---------GEVAKNHSTNNTQDEMIGWDE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------HASN--------V---------ER------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---VDPSEADSLDTPPPVPDFHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HILS-------------------------------------------- ---------------------------------STPTDPVLASTS---------LSIVQ- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------NTTAVTPEDILVHGSP-------- ------------------------------------------------GEE--------- ------------------------------------------------------------ HDLEDLAARLITKVISAATQEV-------------------------------------- --------------------------LSVTSCQVVD--KSL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PN----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------CS------------------------------------------- ------------------------------------------------------------ ---------------------S-------------------------------------- ------------------------------------------------------------ -----------------------------------------GG----------------- ---------------------------------------------------L-------- ------------YPE----LE--------------------------------------- ------------------------------------------------------------ ----------------PIIATQKHHHLSTSPSQVGCDCREATEKEA---------QAVPN GCS-----------------------------------------SSPVWK---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------SVDVSHINHQKNAVHSSHWSTQLP---------------QEAQTSP ---------------------------VLN-----------------------------I K----------------------------------------------------------- ------------------------------------------------------LKG-DE AAPL------------------------------AEDSA---CSTCHSEDGIS--SE--D L-------QSSLFDNQSDVIQLTDLS---------------------------------- ----------------------------------------------------AGEAAQGQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VQAESLTEGLVLSATEEDSLDAACEI KGLNAVGVRNGAHGTCEVETDQSG----GSDVNSMDSVDSG-CTMGALESK----GNHAA -SSTGLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQEFQICHIEGT QQQVDKALSLIGKKFKDLDLNNLYAAPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEI GVICAAPAVEG-AWWRAQVITFYKESNEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSAEATSELEEMTRGVSLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SSYDNNTGLPLVHLWNMVGDEV------------------------------ -----------------------------ISVNRTLAERGLG-VWVDGF----------- ------------------------------------------------------------ - >ENSACLP00000033089 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVVPYTLPGVLALI-GWWWYISRKRERLINHDRTE-GTPTTTD----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KT---------------SS- ------ADGSN-------------------------GLVEKDTVSP-TNDTDSPIHRPP- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------NASNQR-TQHE--------- -NISQIHFQHTEASPSLAQSSE-----------------KFSC----------------- -----------------------------------------NSERMKQGVHRPPQSALP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SLDKDDSLQVSSKDRKDPERS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --LSLALGTELNLVKNPVSDLERA-----TFS---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------YQSTK---V-------------------------------------- ------------------------------------------------------------ ------------------------------TSSFPTTSLLSGAERPD-----------P- ------------------------------------------------------------ -----E---------GEVAKNHSTNNTQDEMIGWDE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------HASN--------V---------ER------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---VDPSEADSLDTPPPVPDFHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HILS-------------------------------------------- ---------------------------------STPTDPVLASTS---------LSIVQ- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------NTTAVTPEDILVHGSP-------- ------------------------------------------------GEE--------- ------------------------------------------------------------ HDLEDLAARLITKVISAATQEV-------------------------------------- --------------------------LSVTSCQVVD--KSL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PN----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------CS------------------------------------------- ------------------------------------------------------------ ---------------------S-------------------------------------- ------------------------------------------------------------ -----------------------------------------GG----------------- ---------------------------------------------------L-------- ------------YPE----LE--------------------------------------- ------------------------------------------------------------ ----------------PIIATQKHHHLSTSPSQVGCDCREATEKEA---------QAVPN GCS-----------------------------------------SSPVWK---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------SVDVSHINHQKNAVHSSHWSTQLP---------------QEAQTSP ---------------------------VLN-----------------------------I K----------------------------------------------------------- ------------------------------------------------------LKG-DE AAPL------------------------------AEDSA---CSTCHSEDGIS--SE--D L-------QSSLFDNQSDVIQLTDLS---------------------------------- ----------------------------------------------------AGEAAQGQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VQAESLTEGLVLSATEEDSLDAACEI KGLNAVGVRNGAHGTCEVETDQSG----GSDVNSMDSVDSG-CTMGALESK----GNHAA -SSTGLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQEFQICHIEGT QQQVDKALSLIGKKFKDLDLNNLYAAPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEI GVICAAPAVEG-AWWRAQVITFYKESNEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSAEATSELEEMTRGVSLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SSYDNNTGLPLVHLWNMVGDEV------------------------------ -----------------------------ISVNRTLAERGLG-VWVDGF----------- ------------------------------------------------------------ - >ENSPNYP00000026868 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVVPYTLPGVLALI-GWWWYISRKRERLINHDRTE-GTPTTTD----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KT---------------SS- ------ADGSN-------------------------GLVEKDTVSP-TNDTDSPIHRPP- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------NASNQR-TQHE--------- -NISQIHFQHTEASPSLAQSSE-----------------KFSC----------------- -----------------------------------------NSERMKQGVHRPPQSALP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SLDKDDSLQVSSKDRKDPERS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --LSLALGTELNLVKDPVSDLERA-----TFS---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------YQSTK---V-------------------------------------- ------------------------------------------------------------ ------------------------------TSSFPTTSLLSGAERPD-----------P- ------------------------------------------------------------ -----E---------GEVAKNHSTNNTQDEMIGWDE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------HASN--------V---------ER------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---VDPSEADSLDTPPPVPDFHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HILS-------------------------------------------- ---------------------------------STPTDPVLPSTS---------LSIVQ- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------NTTAVTPEDILVHGSP-------- ------------------------------------------------GEE--------- ------------------------------------------------------------ HDLEDLAARLITKVISAATQEV-------------------------------------- --------------------------LSVTSCQVVD--KSL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PN----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------CS------------------------------------------- ------------------------------------------------------------ ---------------------S-------------------------------------- ------------------------------------------------------------ -----------------------------------------GG----------------- ---------------------------------------------------L-------- ------------YPE----LE--------------------------------------- ------------------------------------------------------------ ----------------PIIATQKHHHLSTSPSQVGCDCREATEKEA---------QAVPN GCS-----------------------------------------SSPVWK---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------SVDVSHINHQKNAVHSSHWSTQLP---------------QEAQTSP ---------------------------VLN-----------------------------S K----------------------------------------------------------- ------------------------------------------------------LKG-DE AAPL------------------------------AEDSA---CSTCHSEDGIS--SE--D L-------QSSLFDNQSDVIQLTDLS---------------------------------- ----------------------------------------------------AGEAAQGQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VQAESLTEGLVLSATEEDSLDAACEI KGLNAVGVRNGAHGTCEVETDQSG----GSDVNSMDSVDSG-CTMGALESK----GNHAA -SSTGLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQEFQICHIEGT QQQVDKALSLIGKKFKDLDLNNLYAAPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEI GVICAAPAVEG-AWWRAQVITFYKESNEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSAEATSELEEMTRGVSLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SSYDNNTGLPLVHLWNMVGDEV------------------------------ -----------------------------ISVNRTLAERGLG-VWVDGF----------- ------------------------------------------------------------ - >ENSNBRP00000008244 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVVPYTLPGVLALI-GCWWYISRKRERLINHDRTE-GTPTTTD----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KT---------------SS- ------ADGSN-------------------------GLVEKDTVSP-TNDTDNPIHRPP- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------NASNQR-TQHE--------- -NISQIHFQHTEASPSLAQSSE-----------------KFSC----------------- -----------------------------------------NSERMKQGIHRPPQSALP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SLDKDDSLQVSSKDRKDPERS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --LSLALGTELNLVKDPVSDLERA-----TFS---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------YQSTK---V-------------------------------------- ------------------------------------------------------------ ------------------------------TSSFPTTSLLSGAERPD-----------P- ------------------------------------------------------------ -----E---------GEVAKNHSTNNTQDEMIGWDE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------HASN--------V---------ER------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---VDPSEADSLNTPPPVQDFHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HILS-------------------------------------------- ---------------------------------STPTDPVLASTS---------LSIVQ- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------NTTAVTPEDILVHGSP-------- ------------------------------------------------GEE--------- ------------------------------------------------------------ HDLEDLAARLITKVISAATQEV-------------------------------------- --------------------------LSVTSCQVVD--KSL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------PN----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------CS------------------------------------------- ------------------------------------------------------------ ---------------------S-------------------------------------- ------------------------------------------------------------ -----------------------------------------GG----------------- ---------------------------------------------------L-------- ------------YPE----LE--------------------------------------- ------------------------------------------------------------ ----------------PIIATQKHHHLSTSPSQVGCDCREATEKEA---------QAVPN GCS-----------------------------------------SSPVWK---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------SVDVSHINHQKNAVHSSHWSAQLP---------------QEAQTSP ---------------------------VLN-----------------------------I K----------------------------------------------------------- ------------------------------------------------------LKG-DE AAPL------------------------------AEDSA---CSTCHSEDGIS--SE--D L-------QSSMFDNQSDVIQLTDLS---------------------------------- ----------------------------------------------------AGEAAQGQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VQAESLTEGLVLSATEDDSLDAACEI KGLNAVGVRNGAHGTCEVETDQSG----GSDVNSMDSVDSG-CTMGALESK----GNHAA -SSTGLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQEFQICHIEGT QQQVDKALSLIGKKFKDLDLNNLYAAPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEI GVICAAPAVEG-AWWRAQVITFYKESNEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSAEATSELEEMTRGVPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SSYDNNTGLPLVHLWNMVGEEV------------------------------ -----------------------------ISVNRTLAERGLG-VWVDGF----------- ------------------------------------------------------------ - >ENSACIP00000014543 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVVPYTLPGVLALI-GWWWYISRKKERLISHDCTE-GTPTAVD----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------PS- ------ADSTN-------------------------GLVEKGTVSS-TNDTEGSTHRPP- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KASNQR-TQHE--------- -YISQIHFQNTEATPSLAKSSE-----------------DISP----------------- -----------------------------------------KFGRMGQGIHRPPQSALP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SLGKDDNLEVSLKDHKDPERS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --LPFALSTELSLVKDPASAPKEATLEEITFS---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CHSTK---V-------------------------------------- ------------------------------------------------------------ ------------------------------TSPFPTTSQLSDAERPD-----------P- ------------------------------------------------------------ -----E---------GEVAKNHNTNNTQDEIVG--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ VL---------------------------------------------------TPA---- ----------------------------------------------------------NV -ERVDPSEADSLDTPLPVQDLHQLLS---------------------------------- ------------------------------------------------------------ ------------------------TPPAPALT---------------------------- --STALSIVQDT------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------TTTVTPENIRAHSSP-------- ------------------------------------------------EEE--------- ------------------------------------------------------------ HDLEHLAAGLITKVISAATQEV-------------------------------------- --------------------------LSVTRCQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DNSQPSC----------------------------------------- S----------------------------------------------------------- -----SST----------------------------------------------P----- ---------ETSSRLC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PE----LE--------------------------------------- ------------------------------------------------------------ ----------------PVTATQQHHHLSTSPSQVGCDCREATEKEG---------QAVPN GCS-----------------------------------------SSPVWK---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------SVDVSHRIHQTNADQSGRWSTQSP---------------QAVQTAP ----------------------------LN-----------------------------I K----------------------------------------------------------- ------------------------------------------------------LKG-DE AAPL------------------------------AEDSA---CSTCHSEDGIS--SE--D L-------HSSMFDNQSDVIQLTDLSTR-------------------------------- -------------------------VASQVE--------------GLVLSVT-------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------EDSMDVVCEI KGLNAMGLRNGAHGTCEVETDQSG----GSDVNSMDSVDSG-CTMGAVESK----GNHVA SSSSELIIWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQEFQICHIEGT QQQVDKALLLIGKKFKDLDLNNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVEG-AWWRAQVITFYKEANEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSAEATSALEEITRGVPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNDTGLPLVHLWNMVGEEV------------------------------ -----------------------------ISVNRTLAERGLG-VWVDGF----------- ------------------------------------------------------------ - >ENSLCRP00005053417 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVVPYTLPGVLALI-GWWWYISRKKERLISHDSPE-GPLTTVG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------SP- ------AEGSN-------------------------GLVEKDTLSP-PNDTESPTHITP- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KVSLQR-TPHE--------- -NISQVHVQGTEAEHSLVQSSEEAAPHLDRIRQEEVHK---------------------- ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LVSTLQSRSEKDSLQV TLK--------DL-KDP--------------------------------------DENSS --PALVKKLGKDLVKDAT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------TVEVILPIQSTK---F-------------------------------------- ------------------------------------------------------------ ------------------------------TSSSSTTAHLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAKNYSTVSTQDEIIV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ AA---------------------------------------------------TPA---- ----------------------------------------------------------KV -QRVIPSEADSLETPPSAQDFHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HILT-------------------------------------------- ---------------------------------STPT----------------------- ----------------------------------------------------FPS----- ------------------------------------------------------------ -----------------------------------PA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------WASTALTVVQDSNTT LL---------------------------------------------------------- -----TQDS----------------------IQVR------------------------- ------------------------------------------------------------ ---------------------------------------------------S-------- ------------------------------------------------GED--------- ------------------------------------------------------------ QDLELLASGLITEVISAATQEI-------------------------------------- --------------------------LGFRGCQVT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DHSQPSC----------------------------------------- S----------------------------------------------------------- -----SST----------------------------------------------P----- ---------LGSGRQC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SQ----LE--------------------------------------- ------------------------------------------------------------ ----------------PITTAQQHYHLLTSPSEEGCETKDATEKEE---------TGMPN GCS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------LISHRVQQTNNAQRGHWPRPLY---------------QAAQNSP ---------------------------SFH-----------------------------M K----------------------------------------------------------- ------------------------------------------------------LKG-NE VVML------------------------------TEDSA---CSTWHSEDGIS--SE--D L-------QNSMFDNQVEVIQVTDLS---------------------------------- ----------------------------------------------------AREAMQPQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLVETTTEATILAETQGNSVDAVCEN KRLNGIGFRNGALGTCEVETDQSG----GSDVNSMDSVDSG-CTMGAGETQ----PNHTA SSSSELIIWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQEFQICHIEGT QQQVDKALSLIGKKFKDLDLTNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVEG-AWWRAQVITFYKETNEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSPDATSALEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNMVGDEVRCLNTTVYVAYICSFRIIYCMLCTYTGSFK VLLTSWNKKVLNFTTECFFVCFVCNELAII------------------------------ ------------------------------------------------------------ - >ENSATEP00000006779 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVVPYTLPGVLALI-GWWWYITRKKERLIR------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PD TKDAGP------------KTDGLRSSTAEGRH---------------------------- -------------CVVEKNTNDTEIP-------------TC-----T------------- ---------------P-----------------------LKVTKQR-TGNE--------- -NIFHIHVQNTEAAPLLEQSSEEAMLELGKIREEGVHK---------------------- ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------LVQASGKEDSLQ-KLLTD------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------HKSPEKS----LPSV------ ------------------------------------------------------------ ------------------------IVTELEKHLAKDQVSAAIMLV--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PCKSTK---V-------------------------------------- ------------------------------------------------------------ ------------------------------TQSSPTAVDLTDARRPE-----------P- ------------------------------------------------------------ -----E---------GEVAKHHNNVGTQDEMVV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------S------------------ AV---------------------------------------------------TPT---- ----------------------------------------------------------KM -QRVILSQADYLETPPSMQDSHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HILT-------------------------------------------- ---------------------------------STPTALAQTSTA---------LSIVKN SITTSVNTEDIQI----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------SSRS-------- ------------------------------------------------GEE--------- ------------------------------------------------------------ QDLELLAAGLITEVISAATQEV-------------------------------------- --------------------------LGVSSCQIT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDNHPSC----------------------------------------- N----------------------------------------------------------- -----IST----------------------------------------------A----- ---------LADGRLC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SH----QA--------------------------------------- ------------------------------------------------------------ ----------------PITAVQRHHNLLKNSSVLSYESREAIEKDG---------QQMHN GCS-----------------------------------------SALVWK---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------PAEVSRRVHQTDIVQRGHWPAPSH---------------QAPQSSP ---------------------------LLN-----------------------------M K----------------------------------------------------------- ------------------------------------------------------LKG-DN VAVL------------------------------VEDSV---CSTCPSEDCIS--SE--D F-------ESSMFDNQTDVIQVTDLS---------------------------------- ----------------------------------------------------ARESTQPQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLFKTTTEATVLAASEENSVDSVCEK KRLNGLALKNGAHGICEVETDHSG----GSDVNSMDSVDSG-YNLGAGENQ----SSHVA SSNSAIIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQEFQICHIEGI QQQVDKALSLVGKKFKDLDLTNVYAPSPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVEG-AWWRAQVITFYKETSEVEIRYVDYGGYDRVKIESLRQIRSDFVTLPFQ GAEVLLDNIAPIP------------------------GEDSFSAEATSALEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNSTGLPLVHLWNMVGDEV------------------------------ -----------------------------ISVNRTLVERGLG-SWVDGF----------- ------------------------------------------------------------ - >ENSPRNP00000030465 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVVPYTLPGALALI-GLWWYISRKKERPISHDSPE-EASTAVG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------SP- ------AEGSN-------------------------GLVEKGTVSP-TNDGESPTHRSA- -KD--------------------------------------------------------- ---------------------QTQ------------------------------------ ------------------------------------------------------------ ----QIHVQDNKIAPSLELSSEEAAPHLGRITPVGVHK---------------------- ----------------------------------------------------------PS D--------------------------------------------------STL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SSFGKEDCLQILLKDPH--------------------------GSLS PALVKAPEEHQVKDPASALEVA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------VEDDILSYQATK---L-------------------------------------- ------------------------------------------------------------ ------------------------------TSSSPTTAHLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAKHHSIINIQDDTVV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ AL---------------------------------------------------TPA---- ----------------------------------------------------------KV -QTAIVSEANSLDTPSSMQDLHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HILT-------------------------------------------- ---------------------------------STPNDPAVTPSA---------LSTVQD CTTTAVTTVDVQV----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------HGAI-------- ------------------------------------------------GEE--------- ------------------------------------------------------------ QDLELLAAGLISEVISAATQEV-------------------------------------- --------------------------LGVTSYQVI------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DNSHPSC----------------------------------------- S----------------------------------------------------------- -----DST----------------------------------------------A----- ---------FANSRLC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SQ----QELIT---------------------SQHLCHLT------- ------------------------------------------------------------ ----------SHTYEG--------------------ECREESEKED---------QGMPN GCA-----------------------------------------SVPRWE---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------RVGDCHKVHQT----------------------------------- ------------------------------------------------------------ KS--------------------------------------------EQ------------ ----------------------------SGHCTTPPH-----------QVAQCTVKG-DE AARL------------------------------AEDSA---CSTCHSEDGIS--SD--D L-------HNSLLDNQTDVMQVTDLS---------------------------------- ----------------------------------------------------TTEATQHQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SMAE-TNEATVLALPEDDSMETVCDI KKLNGMGLRNEAHVTCEVETDQSG----GSDVNSMDSVDSG-CTMGVGESQ----SNHTA SSSSELIIWEIEVP-KHLVGRLIGKQGRYVSFLKQASGAKIYISTLPYTQEFQICHIEGT QHQVDKALSLIGKKFKDLDLTNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAGEG-AWWRAQVITFYKETNEVEIRYVDYGGYDRVKIDLLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSAEATSALEEMTRGVALS SVTNWSLYFSSVK-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVRLWNMVGDEV------------------------------ -----------------------------ISVNRTLAERGLG-VWVEGF----------- ------------------------------------------------------------ - >ENSKMAP00000018266 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MQLRFRSVVPYTLPGVLALI-GWWWYTSRKKERLISQESSE-GPPAAEG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KT---------------FQ- ------TEDRN-------------------------GLVEKDTGSS-PHEEDIPTHRPL- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------NLNSQG-TQQE--------- -LIFQIHVEDTEAEPS-------------------------SAKD--------------- ---------CEDAAPVCGRN---------------CGEEVNK----------------PS D--------------------------------------------------LAL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LSFNKED---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----MSEDSWKDL-TDP--------------------------------------DKDSS HVPI-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------RQLEEHLDKDSV GAPEASVEEVDLSCHSTK---V-------------------------------------- ------------------------------------------------------------ ------------------------------ISSSSTAVHLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVATHQSTAQTQEEM----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AL---------------------------------------------------TPA---- ----------------------------------------------------------KV -CRVVQSEADSLETPLSV-DLHK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HLLT-------------------------------------------- ---------------------------------STP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -MALTFTVQDPSTTWRTSEDIHME------------------------------------ ---RSTQ----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------EE--------- ------------------------------------------------------------ HNLELLAAGLITEVISAATQEV-------------------------------------- --------------------------LGVTSCKVT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------QNKQVSS----------------------------------------- S----------------------------------------------------------- -----SSV----------------------------------------------L----- ---------LTSEKPC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SQ----EE-------------------------------TTPAIQQH SWQLR--------------------------------GPGEEAERQGVSN------GSSM AAARADAEATD------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RVHETNGAQSSPWPT------------------------- ------------------------------------------------------------ -----------------------------------------------QLHQATTV----- ---------------------PTTKRRRD------------------------------- -----------------------------------EDST---CSTCHSEDGVS--SE--D L-------QSSVSESQTDLIQVTDLS---------------------------------- ----------------------------------------------------AREAEQVE ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLVETMTE-----AAEDSSVDAVCVI RRPNGISSRDGAHRTCEVDTDQSG----GSDVNSMDSVDSG-CTMSASDNQ----ANSAT SSSSEVIIWEIEVP-KHLVGRLIGKQGRYVSFLKQSSGAKIYISTLPYTQEFQICHIEGV QQQVDKALSLIGKKFKDLDMTNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVEG-AWWRAQVITFYKETDEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSAEATSALEEMTRGVPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLIHLWNMVGEEV------------------------------ -----------------------------ISVNRTLAERNLT-GWVDGF----------- ------------------------------------------------------------ - >ENSGWIP00000025161 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSIIPYTLPGVLALI-GWWWYISRKKDRLVSNDAPE-RTSPAVG----- ---I-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KT---------------SS- ------AEGSN-------------------------GLVEKATVSQ-SNETESPAHRPA- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KVINQS-TQHE--------- -NVSHIPVQDTEAALSLEFNLEEAVP---------------------------------- -------------------NFTRVGQKELFTVSDVT---------------------VP- ------------------------------------------------------------ ------------------------------TFGKEEKLQIFIECHV-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------EPERT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------SLLASETEVGQLVPGLVYEATVE----------------- ------------------------------------------------------------ ----------------------------EPICS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------QSTK---F-------------------------------------- ------------------------------------------------------------ ------------------------------TSSYPMTPLLSEVQRPD-----------P- ------------------------------------------------------------ -----E---------GEVATHHNTICTQEETSC--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ VL---------------------------------------------------TP----- ------------------------------------------------------------ -----------LETPP---------ESK-------------------------------- ------------------------------------------------------------ ---------SLEISPSVPDFTATSTPNA-------------------------------- ------------HVLT-------------------------------------------- ---------------------------------SAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------QGFTTFANPVKSLLHLST------ ------------------------------------------------------------ -------------------KE------QGV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QDLELLAAELITEVISAATQEV-------------------------------------- --------------------------LAVTSCKTLDISRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------C-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GG-ENISLVSNS------- -SRLQSLQESNATMQEHHLAVSVTVDH------------------DCSDVLK-------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KEN---------QGVSN GCA-----------------------------------------TASVWE---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------PLNVNNRLHQTDDTQMGPWP-------------------------- ------------------------------------------------------------ ----------------------------------------------MMLRQALQS----- ---------------------P------------------------------C------- -TVL------------------------------AEDSA---CSTCHSDDVFS--NE--D L-------QNSVLLNQSDTIQGTHLS---------------------------------- ----------------------------------------------------ARDAMRSE ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------CLAETVAEAAISVISEEDSMDAECEI KGLNSMGQRNGAHRMCEAETDQSG----GSDVNSMDSVDSG-CTMGAGESQ----SNH-A SSTSELIVWEIEVP-KHLVGRLIGKQGRYVSLLKQNSGAKIYIFTLPYTQEFQICHIEGT QQQVDKALLLIGKKFKDLDLTNLYAPPPPP-LT---LPSLPITSW--------------- LLLPSGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFMCYSQPGTPALPSPAEV GVICAAPAVEG-AWWRAQVITFYKDTNEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSTEATSALEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNHTGLPLVHLWNMAGDEV------------------------------ -----------------------------ISVNRTLAERGLG-VWVEGL----------- ------------------------------------------------------------ - >ENSHCOP00000010203 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSIVPYTLPGVLALI-GWWWYTSRKKERLISHDDPD-GGPTNGN----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RL---------------SR- ------AVGRN-------------------------GMVEKDTVST-ANNTE-------- -------------------------------HHLTCRHPKDTRKDDEEEQEEY------- ------------IS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ -------------------N------------------------HVADTDTASIMGQTRR EEAVETCGMKLGLDKPTVSTLSSD------------------------------------ -----------------------------------------------D------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------Q------------DKSLNVSLKDHRDLKKSSVP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SCVSEADVDLN------------------------REPRSASY---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------VKEIVLPGQSTR---I-------------------------------------- ------------------------------------------------------------ ------------------------------THSSTMSVCLADAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAKNHSTMTTQDD------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GC------------------ AV---------------------------------------------------IPV---- ----------------------------------------------------------KV -QSVVSSQFESRDIPISLQDFNQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HILT-------------------------------------------- ---------------------------------STPNSLVLTSKAQSASLASQEL----- -----------QV----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------HSGH-------- ------------------------------------------------EEE--------- ------------------------------------------------------------ QDLEILAAGLITEVISAATQQV-------------------------------------- --------------------------FGGPSCPLSDRGQQ-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------C-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------HHPELSNHQKTGCDETQNID-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QGMPN GSF-----------------------------------------PASVWET--------- ------------------------------------------------------------ -----------------------------------------------------------L KVNESAQINTKQKDPM-----------------PKLSH---------------QVADGTP ---------------------------LLN-----------------------------K K----------------------------------------------------------- ------------------------------------------------------LKA-DE SVTQ------------------------------TEDSA---CSTCHSEDGIS--NE--N H-------QHSLTDSQINVSQISDLS---------------------------------- ----------------------------------------------------EKEATQPQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLLETPMEEIIFSLTEENSVDAICGV KLLDGMDLRSGPQG-CEVETDQSG----GSDVNSMDSVDSG-CTMGGRESH----SNPAS SSSSELVIWEIEVP-KLLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQEFQICHIEGM QQQVDKALSLIGKKFKDMDLTNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPTLPSPAEV GVICAAPAVEG-AWWRAQVITFYKESNEVEIRYVDYGGYDRVKIDSLRQIRSDFVTLPFQ GAEVLLDNVAPLP------------------------GEDRFSSEATSVLEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDTNTGLPLVHLWNMVGEEV------------------------------ -----------------------------ISINRTLAERGFG-VWVDGF----------- ------------------------------------------------------------ - >ENSORLP00020025560 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSVVPYTLPGVLVLI-GWWWFTSRKKERLVGQGASE-APPTPVS----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KA---------------CQ- ------AEGSN-------------------------GLVDKGTVHC-PQEADCPTLRPA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GVNDLSSQHEGGSQDS KTAPSLDLGCEDASP-------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PCRMGLGEFEAPDSPLASHEDQEFSERL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------LKEHTEPE---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GGSLFASLERRPDEDSGVASGASRGAYLPPQACD VSISC------------------------------TAAPLTDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAKHQ-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GFVHSQHEFI-----------C------------------ PHTPPKGSGGT----------------------------------PSEADPLETP----- ------------------------------------------------------------ --------------PPSVQNLHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HILT-------------------------------------------- ---------------------------------STPT----------------------- ----------------------------------------------------GPA----- ------------------------------------------------------------ -----------------------------------FSA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----EDALQG----------------------------------GA------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------GE--------- ------------------------------------------------------------ --LELLAAGLITEVISAATQEV-------------------------------------- --------------------------LGVSSCREP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DRGRP------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GEEPRLQEEEAGASLHCQVLTSSS----------PGG-- -VAEEQLH---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------N GCS-----------------------------------------STAGWGAG-------- ------------------------------------------------------------ -------------GASIPRTDEVRSDG--------------------------------- --------------------------------WSSPSH---------------QAP---P ---------------------------PLN-----------------------------T K----------------------------------------------------------- ------------------------------------------------------EKG-GE GVAL------------------------------AEDSA---CSTCHSEDGVS--SE--E L-------QSSAFDRPAEAVQVSHLS---------------------------------- ------------------------------EDGGSSQPDSSTEDSA-------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------L KRLNGLGLKNGAHSTCEADTDQSG----GSDVNSMDSVDSG-CTMGAAEGQ----ASGAA SSSSGLVIWEIEVP-NRFVGRLIGKQGRYVSYLKQSSGAKIYISTLPYTQDFQICHIEGE QQQVDKALSLIGKKFKDLDLTNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAGEG-AWWRAQVITFYKETNEVEIRYVDYGGYDRVKIDALRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSSEATSAFEEITRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNMLGEEV------------------------------ -----------------------------VSVNRTLAERGLA-VWVDGF----------- ------------------------------------------------------------ - >ENSOMEP00000012529 MF---------------------------------------------------------- -----------------------------SDW--------------CWSSS--------- -----TWEGELDSDRSNCGCR--------------------------------------- ---------------------------------SAEE----------------------- ------MPLRLRSVVPYTLPGVLVLI-GWWWFTSRKKERLVSQGAPE-APPTPVS----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KT---------------SQ- ------AEGSN-------------------------GLVEKGTVHF-PPEVDCPSLRPA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------EVNDLSLQYEGGSQFS KTAPSLDLSLEDAIP-------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------LCRASLVEFEPSDSTLPSHEDQEFLAGV------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------LKEHTEPEAVSS------------ ------------------------------------------------------------ --------------------------------------------------------LERR LDEDSVPSGGAD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LPPQASK---I-------------------------------------- -----------------------SGL---------------------------------- ----C------------------------------TAAPLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAKHQ-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GFVHLQHELL-----------C------------------ PH---------------------------------------------------TPS---- ------------------------------------------------------------ -TSSVPSESDTLETPPSVENFHQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------HILT-------------------------------------------- ---------------------------------STPT----------------------- ----------------------------------------------------GPA----- ------------------------------------------------------------ -----------------------------------PSA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----DNALQG----------------------------------GT------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------EE--------- ------------------------------------------------------------ EQLELLAAGLITGVISAASQEV-------------------------------------- --------------------------LGVSSCRVT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DSSRP------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GEEPPPQ-EEAGASLHSQLLMSSS----------PGGCR DVAEEKLL---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------N GCS-----------------------------------------ATPGW----------- ------------------------------------------------------------ --------------------------GTPEA------------------SVPPTDDVQVL -------------------------------CWSSPPH---------------KAP---P ---------------------------TLK-----------------------------A K----------------------------------------------------------- ------------------------------------------------------EKG-GE RVTL------------------------------TEDSA---CSTCHSEDGVS--SE--E L-------QSSAFDRPAEAVQVSHLS---------------------------------- ------------------------------EGGGLPQPNASTEESS-------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KRLNGISL--GTHGTCDADTDQSG----GSDVNSMDSVDSG-FTMGAGEGQ----ASSAI SSGSGLVIWEIEVP-NRFVGRLIGKQGRYVSYLKQSSGAKIYISTLPYTQEFQICHIEGE QQQVDKALSLIGKKFKDLDLTNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAGEG-AWWRAQVITFYKESNEVEIRYVDYGGYDRVKIDALRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSSEATTAFEEITRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNMLGEEV------------------------------ -----------------------------VSVNRTLAERGLA-VWVDGF----------- ------------------------------------------------------------ - >ENSPMEP00000030100 MIQ----------------LITR------------------------------------- ----------------------------CSVW--------------CLI----------- ------------------------------------------------------------ ------------------------------------E----------------------- ------MPVRFRSVVSYTMPGVLVLI-GWWWYTSRKKERPIGQKSPE-VSSTSVR----- ---F-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KD---------------SH- ------QECNN-------------------------GLL--------------------- ----------------------------------------------------YEEESPAF TNHSNENTENEIIS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------T----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------QDLE--- ---------------------------AISLLEQTCNDVHFCGRTIHEEADRPSNIVAPT FRDSDLVEELVKPLKGPECDSTPDFIDELEK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CPATELDPLPEDSVEEVVLLSNDPKDARFSPMAINLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVATHHSAVAAQEEAI---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ LF---------------------------------------------------TST---- ----------------------------------------------------------ET -HRMASSDGDSLENALSIQDLHK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------CILT-------------------------------------------- ---------------------------------STPT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ILSSTVQGTSTSLDTSVDVHFK------------------------------------ ---ENPQ----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------EM--------- ------------------------------------------------------------ SDLELLAAGLITEVLSAATQEV-------------------------------------- --------------------------LGTSSCEIA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ANTKPSN----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------TSVTLAGGTRSSQLDPITEDFPADVPSQRN-------------------- ------------------------------------------------------------ --------------------------H--------------------------------- ----------------------------------------------------------EH ------------------------------------------------------------ -----------------------------------------AEKEV---------QGVPK GGS-----------------------------------------VTPVW----------- ------------------------------------------------------------ ------------------------------------------------------------ -------VET----------RILKTNSAQNAAWPTLPH---------------Q------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RETLLNK--------------------HKC-DD AAVL------------------------------TEDSA---CSTYHSEEGNS--SE--D L-------QSSTLENPAGVLKITDSS---------------------------------- ----------------------------------------------------ANETVPPQ SAAGS------------------------------------------------------- ------------------------------------------------------------ --------------------------ITKEAEGNS-------------------DAACGI KKVNGDDLRNGAHGTCELDTDQSG----GSDVNSMDSVDSG-CTMSLCENQ----GNNST SSTSELVIWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQDFQICHIEGL QQQVDKALSFIGKKFKDLDLTNLYA---PP-LT---LPSLPITSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVDG-AWWRAQVISFYKETDEVEIRYVDYGGYDKVKIDSLRQIRSDFVTLPFQ GAEVLLDNVAPLP------------------------GEDCFSTDATTTLEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNLVGDEV------------------------------ -----------------------------VSVNRTLAERGLT-VWVDGF----------- ------------------------------------------------------------ - >ENSPFOP00000005578 MIQ----------------LITR------------------------------------- ----------------------------CSVW--------------CLI----------- ------------------------------------------------------------ ------------------------------------E----------------------- ------MPVRFRSVVSYTMPGVLVLI-GWWWYTSRKKERPIGQKSPE-VSSTSVR----- ---F-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KD---------------SH- ------QECNN-------------------------GLL--------------------- ----------------------------------------------------YEEESPAF TNHSNENTENEIIS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------T----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------QDLE--- ---------------------------AISLLEQTCNDVHFCGRTLHKEADRPSNIVAPT FRDSDLVEELVKPLKGPECDSTPDFIDELEK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CPATELDPLPEDSVEEVVLLSNDPKDGRFSPMAINLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVATHHSAVTAQEEAV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ LF---------------------------------------------------TST---- ----------------------------------------------------------ET -HRMASSDGDSLENALSIQDLHK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------CILT-------------------------------------------- ---------------------------------STPT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ILSSTVQGTSTSLDTSVDVHFK------------------------------------ ---ENPQ----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------EM--------- ------------------------------------------------------------ SDLELLAAGLITEVLSAATQEV-------------------------------------- --------------------------LGTSSCEIA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ANTKPSN----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MSVTLAGGTRSSQLDPITEDFPADVPSQRN-------------------- ------------------------------------------------------------ --------------------------H--------------------------------- ----------------------------------------------------------EH ------------------------------------------------------------ -----------------------------------------AEKEV---------QGVPK GGS-----------------------------------------VTPVW----------- ------------------------------------------------------------ ------------------------------------------------------------ -------VET----------RILKTNSAQNAAWPTLPH---------------Q------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RETLLNK--------------------HKC-DD AAVL------------------------------TEDSA---CSTYHSEEGNS--SE--D L-------QSSTLENPAGVLKITDSS---------------------------------- ----------------------------------------------------ANETVPPQ SAAGS------------------------------------------------------- ------------------------------------------------------------ --------------------------ITKEAEGNS-------------------DAACGI KKVNGDDLRNGAHGTCELDTDQSG----GSDVNSMDSVDSG-CTMSLCENQ----GNNST SSTSELVIWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQDFQICHIEGL QQQVDKALSFIGKKFKDLDLTNLYA---PP-LT---LPSLPITSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVDG-AWWRAQVISFYKETDEVEIRYVDYGGYDKVKIDSLRQIRSDFVTLPFQ GAEVLLDNVAPLP------------------------GEDCFSTDATTTLEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNLVGDEV------------------------------ -----------------------------VSVNRTLAERGLT-VWVDGF----------- ------------------------------------------------------------ - >ENSPLAP00000003857 MIQ----------------LITR------------------------------------- ----------------------------CSVW--------------CLI----------- ------------------------------------------------------------ ------------------------------------E----------------------- ------MPVRFRSVVSYTMPGVLVLI-GWWWYTSRKKERPIGQKSPE-VSSTSVR----- ---F-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KD---------------SH- ------QDCNN-------------------------GLL--------------------- ----------------------------------------------------YEEESPAF TNHSNENTENEIIS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------T----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------QDLE--- ---------------------------AISLLEQTCNDVHFCGRTLHKEADRPSNIVAPT FRDSDLVEELVKPLKGPECDSTPDFIDELEK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CPATELDPLPEDSVEEVVLLSNDPKDARFSPMAINLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVATHHSAVTAQEEAV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ LF---------------------------------------------------TST---- ----------------------------------------------------------ET -HRMASSDGDSLENALSIQDLHK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------CILT-------------------------------------------- ---------------------------------STPT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ILSSTVQGTSTSLDTSVDVHFK------------------------------------ ---ENPQ----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------EM--------- ------------------------------------------------------------ SDLELLAAGLITEVLSAATQEV-------------------------------------- --------------------------LGTSSCEVA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ANTKPSN----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MSVTLAGGTRSSQLDPITEDFPADVPSQGN-------------------- ------------------------------------------------------------ --------------------------H--------------------------------- ----------------------------------------------------------EH ------------------------------------------------------------ -----------------------------------------AEKEV---------QGVPK GGS-----------------------------------------VTPVW----------- ------------------------------------------------------------ ------------------------------------------------------------ -------VET----------RILKTNSAQNAAWPTLPH---------------Q------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RETLLNK--------------------HKC-DD AAVL------------------------------TEDSA---CSTYHSEEGNS--SE--D L-------QSSTLENPAGVLKITDSS---------------------------------- ----------------------------------------------------ANETVPPQ SAAGS------------------------------------------------------- ------------------------------------------------------------ --------------------------ITKEAEGNS-------------------DAACGI KKVNGDDLRNGAHGTCELDTDQSG----GSDVNSMDSVDSG-CTMSLCENQ----GNNST SSTSELVIWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQDFQICHIEGL QQQVDKALSFIGKKFKDLDLTNLYA---PP-LT---LPSLPITSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVDG-AWWRAQVISFYKETDEVEIRYVDYGGYDKVKIDSLRQIRSDFVTLPFQ GAEVLLDNVAPLP------------------------GEDCFSTDATTTLEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNLVGDEV------------------------------ -----------------------------VSVNRTLAERGLT-VWVDGF----------- ------------------------------------------------------------ - >ENSPREP00000021483 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPVRFRSVVSYTMPGVLVLI-GWWWYTSRKKERPIGQKSPE-VSSTSVS----- ---F-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KD---------------SH- ------QECNN-------------------------GLL--------------------- ----------------------------------------------------YEEESPAF TNHSNENTENEIIS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------T----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------QDPE--- ---------------------------AISLLGQTCNDVNFCGRTIHEEADRPSNIVAAT FRDSDLVEESVKPLKAPECDSTPDFIGELEK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CPATELDPLPEDSVEEVALLSNGSKDTRFSPITINLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVATHHNAVTAQEEAV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ LF---------------------------------------------------TSA---- ----------------------------------------------------------ET -HRMASSDGDYLENALSVQDFHK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------CILT-------------------------------------------- ---------------------------------STPT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ILFSTVQGTSTSLDTSVEVHFK------------------------------------ ---ENPQ----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------M--------- ------------------------------------------------------------ SDLELLAAGLITEVLSAATQEV-------------------------------------- --------------------------LGTSSCEVE------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ANTKPSN----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MSVTLASGTRSSQLDPITEDFPADVPSQRN-------------------- ------------------------------------------------------------ --------------------------H--------------------------------- ----------------------------------------------------------EH ------------------------------------------------------------ -----------------------------------------AEKEV---------QGVPK SGS-----------------------------------------VTPAW----------- ------------------------------------------------------------ ------------------------------------------------------------ -------VET----------RILKTNSSQNAAWPTLPH---------------Q------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RETLLNK--------------------HKC-DD AAVL------------------------------TEDSA---CSTYHSEEGNS--SE--D L-------QSSTLENPAGVLKITDSS---------------------------------- ----------------------------------------------------ANETVPPQ SAAGS------------------------------------------------------- ------------------------------------------------------------ --------------------------IPKEAEGNS-------------------DAACGI KKVNGDDLRNGAHGTCELDTDQSG----GSDVNSMDSVDSG-CTMSLCENQ----GNNST SSTSELVIWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQDFQICHIEGL QQQVDKALSFIGKKFKDLDLTNLYA---PP-LT---LPSLPITSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVDG-AWWRAQVISFYKETDEVEIRYVDYGGYDKVKIDSLRQIRSDFVTLPFQ GAEVLLDNVAPLP------------------------GEDCFSTDATTTLEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNLVGDEV------------------------------ -----------------------------VSVNRTLAERGLT-VWVDGF----------- ------------------------------------------------------------ - >ENSXMAP00000012233 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPVRFRSVVSYTMPGVLVLI-GWWWYTSRKKERPVGPKSPE-VPSTSVS----- ---F-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KD---------------SH- ------QECNN-------------------------GLL--------------------- ----------------------------------------------------YEEESPAF TNHSNENTENEIIS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------T----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------QDPE--- ---------------------------AISLLEQACNDVHFCGRTMHEEADRPSNIITPT FRDSDLVEESMKPLKGPECDSTPDFIGELEK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CPATELDLLPEDLVEEVALLSNDSKDTRFSPMAINLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVATHHSAVTSQEEAV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ LF---------------------------------------------------TSA---- ----------------------------------------------------------ET -HRMASSDGDSLENALSVQDLHK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------CILT-------------------------------------------- ---------------------------------STPT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ILSSEVQGTSTSLDTSVDVHFK------------------------------------ ---ENPQ----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------EM--------- ------------------------------------------------------------ SDLELLAAGLITEVLSAATQEV-------------------------------------- --------------------------LGTSSCEVS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ANTKPSN----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MSVTLAGGTRSSLLDPIMEDFPADVPSQGN-------------------- ------------------------------------------------------------ --------------------------H--------------------------------- ----------------------------------------------------------EH S----------------------------------------------------------- ---------------------------------------EAAEKEV---------QAVPK GFS-----------------------------------------VTPGWG---------- ------------------------------------------------------------ ------------------------------------------------------------ ------NVET----------RILKTKSAQNAAWPTLPH---------------Q------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RETLLN----------------------RS-DD ASVL------------------------------TEDSA---YSTYHSEEGNS--SE--D L-------QSSMLGNPAGVLKITDSS---------------------------------- ----------------------------------------------------ANETVPLQ SAAGS------------------------------------------------------- ------------------------------------------------------------ --------------------------SAKEAGGNS-------------------DAVCGI KKVNGDDLRNGAHGTCELDTDQSG----GSDVNSMDSVDSG-CTMSICENQ----GNNST SSTSELVVWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQDFQICHIEGL QQQVDKALSFIGKKFKDLDLRNLYA---PP-LT---LPSLPITSW--------------- LLLPSGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEM GVICAAPAVDG-AWWRAQVISFYKETDEVEIRYVDYGGYDKVKLDTLRQIRSDFVTLPFQ SAEVLLDNVAPLP------------------------GEDCFSTDATTTLEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDDNTGLPLVHLWNLVGDEV------------------------------ -----------------------------ISVNRTLAERSLT-VWVDGF----------- ------------------------------------------------------------ - >ENSXCOP00000007014 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPVRFRSVVSYTMPGVLVLI-GWWWYTSRKKERPVGPKSPE-VPSTSVS----- ---F-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KD---------------SH- ------QECNN-------------------------GLL--------------------- ----------------------------------------------------YEEESPAF TNHSNENTENEIIS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------T----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------QDPE--- ---------------------------AISLLEQACNDVHFCGRTMHEEADRPSNIITPT FRDSDLVEESMKPLKGPECDSTPDFIGELEK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CPATELDLLPEDLVEEVALLSNDSKDTRFSPMAINLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVATHHSAVTSQEEAV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ LF---------------------------------------------------TSA---- ----------------------------------------------------------ET -HRMASSDGDSLENALSVQDLHK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------CILT-------------------------------------------- ---------------------------------STPT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ILSSEVQGTSTSLDTSVDVHFK------------------------------------ ---ENPQ----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------EM--------- ------------------------------------------------------------ SDLELLAAGLITEVLSAATQEV-------------------------------------- --------------------------LGTSSCEVS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ANTKPSN----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MSVTLAGGTRSSLLDPIMEDFPADVPSQGN-------------------- ------------------------------------------------------------ --------------------------H--------------------------------- ----------------------------------------------------------EH S----------------------------------------------------------- ---------------------------------------EAAEKEV---------QAVPK GFS-----------------------------------------VTPGWE---------- ------------------------------------------------------------ ------------------------------------------------------------ ------NVET----------RILKTKSAQNAAWPTLPH---------------Q------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RETLLN----------------------RS-DD ASVL------------------------------TEDSA---YSTYHSEEGNS--SE--D L-------QSSMLGNPAGVLKITDSS---------------------------------- ----------------------------------------------------ANETVPPQ SAAGS------------------------------------------------------- ------------------------------------------------------------ --------------------------CVKEAGVNS-------------------DAVCGI KKVNGDNLRNGAHGTCELDTDQSG----GSDVNSMDSVDSG-CTMSICENQ----GNNST SSTSELVVWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQDFQICHIEGL QQQVDKALSFIGKKFKDLDLRNLYA---PP-LT---LPSLPITSW--------------- LLLPSGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEM GVICAAPAVDG-AWWRAQVISFYKETDEVEIRYVDYGGYDKVKLDTLRQIRSDFVTLPFQ SAEVLLDNVAPLP------------------------GEDCFSTDATTTLEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNLVGDEV------------------------------ -----------------------------ISVNRTLAERNLT-VWVDGF----------- ------------------------------------------------------------ - >ENSGAFP00000016221 MIQ----------------LITR------------------------------------- ----------------------------CSVW--------------CLV----------- ------------------------------------------------------------ ------------------------------------E----------------------- ------MPVRFRSVVSYTMPGVLVLI-GWWWYTSRKKDRPVGQKSPE-VPSTSVS----- ---F-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KD---------------SH- ------QECNN-------------------------GLL--------------------- ----------------------------------------------------YEEESPAF TNHSNENTENEIIS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------T----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------QDPE--- ---------------------------AISLLEQTCNDVQFCGRTIHEEADRPSDIIAPT FRDSDLVEESMKPLKGPECDSTPDFIGELEK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CPATELDLLPEDSVEEVALLSNGSKDTRFSPMAINLSDAERPE-----------P- ------------------------------------------------------------ -----E---------GEVATHHSAVTAQEEAV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------C------------------ LF---------------------------------------------------TSA---- ----------------------------------------------------------ET -HRMASSDGDSLENALSVQDLHK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------CILT-------------------------------------------- ---------------------------------STPT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --NLSSDVQGTSTSLDTSVDVHFK------------------------------------ ---EDPQ----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------EM--------- ------------------------------------------------------------ ADLELLAAGLITEVLSAATQEV-------------------------------------- --------------------------LGTNSCELA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ANTKTSN----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MSVTLTGGTRSSQLDPIMEDFPADVPSQGN-------------------- ------------------------------------------------------------ --------------------------H--------------------------------- ----------------------------------------------------------ER S----------------------------------------------------------- ---------------------------------------EAAEKVV---------QAVPK GFS-----------------------------------------VTPEWG---------- ------------------------------------------------------------ ------------------------------------------------------------ ------NVET----------RILKTKSAQNAAWPTLPH---------------Q------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RETLLN----------------------RC-DD AAVL------------------------------TEDSA---CSTYHSEEGNS--SE--D L-----------LGNPAGDLKITDSS---------------------------------- ----------------------------------------------------ANETVPPQ SAAGS------------------------------------------------------- ------------------------------------------------------------ --------------------------TTKE-------------------------AVCGI KKVNGDDLRNGAHGTCELDTDQSG----GSDVNSMDSVDSG-CTMSICENQ----GNNST PSTSELVIWEIEVP-KHLVGRLIGKQGRYVSFLKQNSGAKIYISTLPYTQDFQICHIEGL QQQVDKALSFIGKKFKDLDLTNLYA---PP-LT---LPSLPITSW--------------- LLLPSGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVDG-AWWRAQVISFYKETDEVEIRYVDYGGYDKVKIDSLRQIRSDFVTLPFQ GAEVLLDNVAPLP------------------------GEDCFSTDATTTLEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------SNYDNNTGLPLVHLWNLVGDEV------------------------------ -----------------------------ISVNRTLAERGLT-VWVDGF----------- ------------------------------------------------------------ - >ENSHHUP00000071812 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSIVPYTLPGVLALI-GWWWYISRKKERITNHDSEE-GA-AAMG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LT---------------SPA -----LSEGSN-------------------------GLVEKGTVSP-------------- ------------------------------------------------------------ ----------------------------------------C-----STA-TTPTTSSSCR ERTASSRVR-----LP------------------------KAKEQRSTEQE--------- -VVAQIHI---------------------------------------------------- ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ATK AQAVEVQSTSCSPTERLEASHHPDRASA-----------------VTD------------ ---PG------------------------------VDSCQQTP----------------- ------------------------------------------------------------ ----------------------------------R-SSSP-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------AASPLPTQ TREESSGPQGEHWATVQSPP---------------------------------------- ------------------------------------------------------------ ---------------------------------------AAIALVTVPVKSTVTEQV--- ------------------------------------------------------------ ------------------------------------------------------------ ---------PA-----------------------------------PG-----KDAISTA SEG--LSQTAHA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TTSSSIAADLTNAERPD-----------P- ------------------------------------------------------------ -----E---------GEVAAA---------------------QNLLVELVAKDALPVPSS STKDKLPSSPVISAEM-------------------------------------------- ----------------------------------PAQALKVVIHEPLFPETPTSSPGSYH AVVTSTLASPAQ------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GPQ----- ------------------------------------------------------------ ------------------------------QENGAPC----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ST--------- ------------------------------------------------------------ EELEYLAAGLITEVICAATQEV-------------------------------------- --------------------------LSVTSCPETRFGQSAT------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------EQCFR----------------------------------------------- ------------------------------------------------------------ ------ST----------------------------------------------P----- ---------LANGRPC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SE----QEPLTRNMEEGPSPISHAE---MEWRE-------------- ------------------------------------------------------------ -------------------------------------------QQK---------EGMPN GCP-----------------------------------------PSLAWE---------- ------------------------------------------------------------ ------------------------QMGTANVLSNPWAPASSQEGRQEVRGVPSNLD---- ------------------------------------------------------------ ------------------------------------------------------------ K----------------------------------------------------------- ------------------------------------------------------LKG-DE GVML------------------------------AEDSA---CSTCHSEDGVS--SE--D Q-------QSR--ESREDLIQVSGMS---------------------------------- ----------------------------------------------------EGEGGLPQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------APEEVVTEAEVMAALPGHVLGVVGQV KRLNGMGLRNGSHGMSETETDQSG----GSDVNSMDSVDSG-CTMGARD-S----GSPAM ALGSELVVWEIEVP-KHLVGRLIGKQGRYVSFLKQSSGAKIYISTLPYTQEFQICHVEGS QQQVDKALSLIGKKFKDLDLTNLYAPPPLP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHLFVQQHTHPTYHALHSLDQQMFLCYSQPETPTLPSPAEV GVICAAPAVEG-AWWRAQVISFYKDTNEVEIRYVDYGGYDRVKINTLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GENSFSTEATSALEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDNNTGLPLVQMWNMVGEEL------------------------------ -----------------------------LSVNRTLAERALG-TWVDSF----------- ------------------------------------------------------------ - >ENSHHUP00000023385 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSIVPYTLPGVLALI-GWWWYISRKKERITNYDSEE-GA-AAMG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LV---------------SPA -----PSDGSN-------------------------GLVEKGTVSL-------------- ------------------------------------------------------------ ----------------------------------------C-----TTA-TAPTTSSSCR ERTASSRVR-----PP------------------------KAIEQRSTEQE--------- -VVAQIHI---------------------------------------------------- ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ATK AQAVEVQSTSCSPTEKLEASHHPDRANA-----------------VTD------------ ---PG------------------------------VDGCQQTP----------------- ------------------------------------------------------------ ----------------------------------RSSSSP-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------AASLLPTQ TRKESWALHGEHGATGQRPP---------------------------------------- ------------------------------------------------------------ ---------------------------------------AAIAYVTKPLKSTVTEHV--- ------------------------------------------------------------ ------------------------------------------------------------ ---------PA-----------------------------------PV-----KEAIATA SEALVLSQTAHA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TTSSSTAADLMNAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAAAH-------------EAAVAFTQNLQVELVAKDALLVPSS STKDELSSSSVVPAET-------------------------------------------- ----------------------------------PAQALKVVTHEPLFPETPTSSQGSYH AAVTSTSAFLAQ------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GPQ----- ------------------------------------------------------------ ------------------------------QENGAPC----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SS--------- ------------------------------------------------------------ EELEYLAAGLITEVIWAATQEV-------------------------------------- --------------------------LSVTSCPETWLGQSAA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------EPCCR----------------------------------------------- ------------------------------------------------------------ ------ST----------------------------------------------P----- ---------MANGRPC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SE----QEPLTRNKEEGPSPISHAE---KEWRA-------------- ------------------------------------------------------------ -------------------------------------------QQK---------EGMPN GCP-----------------------------------------PAPAWE---------- ------------------------------------------------------------ ------------------------PMGTANALNNPWAAASSQEGRREASSVPVNLD---- ------------------------------------------------------------ ------------------------------------------------------------ K----------------------------------------------------------- ------------------------------------------------------LKG-NE GAMV------------------------------AEDSA---CSTCHSEDGVS--SE--D Q-------QSR--ESQEDLIQVSGMS---------------------------------- ----------------------------------------------------EGEGGLRQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------APEEVVTKAQVMAVLPGHVLGAVGEV KRLNGMGLRNGSHGMSETETDQSG----GSDVNSMDSVDSG-CTMGARDSS----GSPAR TLGSELIIWEIEVP-KHLVGRLIGKQGRYVSFLKQSSGAKIYISTLPYTQEFQICHIEGS QQQVDKALSLIGKKFKDLNLTNLYAPPSLP-LTMPSLPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHLFVQQHTHPTYHALRSLDQQMFLCYSQPETPTLPSPAEV GVICAAPAVEG-AWWRAQVISFYKETNEVEIRYVDYGGYDRVKIETLRQIRSDFVTLPFQ GAEVLLDSIAPLP------------------------GENSFSTEATSALEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDNNTGLPLVQMWNMVGEEL------------------------------ -----------------------------VSVNRTLAERVLG-TWVDSF----------- ------------------------------------------------------------ - >ENSELUP00000036890 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSIVPYTLPGVLALI-GWWWYISRKKERVTKHDSEE-GA-MAMG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LV---------------SPS -----PSEGSN-------------------------GLVEKGNLSP-------------- ------------------------------------------------------------ ----------------------------------------C-----STAVAAPNTVCSRR ERT------------P------------------------KAREQRLTELE--------- -VVAQIHI---------------------------------------------------- ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ASK TQAVELQSTSLSATERL------------------------------DP---VEAVP--- --APG------------------------------LVSCHQIP----------------- ------------------------------------------------------------ ----------------------------------R-TSSPT--------------PV--- ----------------------------------SPLLTQTP------------------ ------------------------QGEHEAIGGGAPADVAVVTEPAKPTVTEQVQDT--- ---------------------------------------------------------PEE ------------------------------------------------------------ ----------------PV-----------------VVAASEALVQSQMVHTSAADP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------ANAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAAAH-------------EAGGSFIQNLQVELMAKDALPVLCS STKDPLPSSLVMPAE--------------------------------------------- ------------------------------------------------------------ ----------AQAVKVTH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ESPISSQDSHR------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------AD---LT-------------------------------------------- ---------------------------------ST--------------LAS-------- --------------FS----------------------------------APGPQ----- ------------------------------------------------------------ ------------------------------QENGE-S----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SS--------- ------------------------------------------------------------ EVLAHLAAGLITEVISAATQEV-------------------------------------- --------------------------LSMTSCPET------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------RHNQPTA----------------------------------------- GP---------------------------------------------------------- ---GYSST----------------------------------------------P----- ---------LTNGRPC-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SQ----QEPITRHMEDGPSPISHSEAGRADWRE-------------- ------------------------------------------------------------ --------------------------------------------QK---------EVLAN GCPVTWEPIGADNTVSHSWAAATPWQEGRRQAGSLDTRKGEEEV---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -VMV------------------------------AEDSA---CSTCHSEDGVS--SE--D Q-------QGT--ESREDLIQVSGIS---------------------------------- ----------------------------------------------------ERKESPPQ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ALEEVVTE----AALSGHSLAAVSEV KRLNSMCLRNGSHGTSETETDQSG----GSDVNSMDSVDSG-CTMGARD------GSPAI AMGSELIVWEIEVP-KHLVGRLIGKQGRYVSFLKQSSGAKIYISTLPYTQEFQICHIEGS QQQVDKALSLIGKKFKDLDLTNLYAPPPMP------LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHLFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVDG-AWWRAQVISFYKETNEVEIRYVDYGGYDRVKIDTLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GENAFSTEATSALEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDNNTGLPLVQMWNMVGEEL------------------------------ -----------------------------VSVNRTLAERALG-TWVEGF----------- ------------------------------------------------------------ - >ENSSFOP00015019004 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSFVPYTLPGVLVLI-GWWWYISRKKGRITSHDKEE---GTAMG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------SP- ------IEGSN-------------------------GLVELCC----------------- -----TTTAAVPNRTTRDR----------------------------------------- ------------------------------------------------------------ ---------------P------------------------KAVGDKPAEQQ--------- -VLAEVHT---------------------------------------------------- ----------------------------------------------------------A- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------AQ- ------------------------------------------------------------ ---P--------------------------------------P----------------- ------------------------------------------------------------ ----------------------------------R-TPSP-------------------- -----------------------------------PLSSGTP------------------ ------------------------------------------------------------ -----------PFLHHTDMVAPE--ECSPEAIRPENTGKTTGPLLLKLSEESRVSRVPEE EVASNPTSSALSESKQTVTSALGPPKQVCKLLPDKK------------------------ ---ETG---------GP------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------AEISNVVRPE-----------P- ------------------------------------------------------------ -----E---------GEVAA--------------DKITVPFMENLQLDLV-KEEL----S T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LPSVGDHGY----------------- ------------------------------------------------------------ ------------KPARQDSPC--------------------------------------- --PEP------------------------------------------------------- --------------------------------------------------TLS------- ---------------------------------SSS-------------------CQA-- -----------TPS--------------------------LTP--QSGVAR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E------NGL---------------LADHAES-------- ------------------------------------------------GTT--------- ------------------------------------------------------------ EEIERLAAGLITEVISAAAQEV-------------------------------------- --------------------------LAVS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------HSGMVAGEEEE--------------------------------- -------GEDQGRT------------------------ARR------------------- ------TSEL-------------------------------------------------- S----------------------------------------------------------- -----SST----------------------------------------------P----- ---------MSNGRPCAARELLRDGGLT-------------------------------- -----------------------------------PVEA--------------------- ------QH---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------LLQEG--------SSPTGCAETG-------------------- ----RDKEALKRKQLSGGT----DE----------------------------------- ----------------------------------------------------------VN GCL-----------------------------------------GSPAWQTAEDSSS--- --------------DTR----------------SRRRAESGQRITCLGL----------- ------------------------------------------------------------ ------------------------------------KH------------------EATP --------------------------------------------------PSL------A K----------------------------------------------------------- ------------------------------------------------------LQS-EE AITG------------------------------AEDSG---CSTCQSEDGIS--SE--D L-LHSTGLSCTPPETKEVVMHISDIS-----------------------------TQGP- ------------------GKQHDGTARS------------------------TSEGAPPQ H--------------GPCVQESK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -ALNDTGLRNGSH-MSETEADHSG----GSDVNSMDSVDSG-CTLGAGDGSH-ASRQATH PQTSELIIWEIEVP-KHLVGRLIGKQGRYVSFLKQSSGAKIYISTLPYTQEFQICHIEGT QQQVDKALALIGKKFKDLDLTNLYAPPPLP-IT---LPSLPMTSW--------------- LLLPNGVTVEVIVVNIVSAGHAFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPVEV GVICAAPAGEG-AWWRAQVISFYKDSGEVEIRYVDYGGYDRVKIDTLRQIRSDFVTLPFQ GAEVLLDNLAPLP------------------------GADRFSPEATAALEEMTRGVPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSNTGLPLVQLWNMVGDEL------------------------------ -----------------------------VSVNRTLAERGFG-TWVDSF----------- ------------------------------------------------------------ - >ENSPKIP00000039990 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPFRFRSLVPYTVPGVLALLGGWWWYTSRKKGRLAGHDGTE---GMTVD----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LV---------------SP- ------SEGSN-------------------------GLMERHC----------------- -----S------------------------------------------------------ ------------------------------------------------------------ ---------------PAV----------AGAPYGSDRDGQKVKGEKPTEQQ--------- -VLVQVHV---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------PA-------------------EAK-------------------- ------------------PPSPA------------------------------QSLETAD SCAAAASPQLGDAADWENSSVVAVTVMAVATL---------------------------- -----LAEEETRESKGPEEDA--------------------------------------- ------------------------------------------------------------ ---------------------ASIQTSSPAPC---------------------------- -------GLPA-----------------------------------PG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------TAVGAVA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------AELPNLVRPE-----------P- ------------------------------------------------------------ -----E---------GEVAA--------------DKTTVPFVESIQPDAV-KEDL----P VAEE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------QACGSSRQVVLCSE---------PV A----------------------------------------------------------- ---------------------------------EAPS----------------------- ------------------------------------------------------------ -----------------------------PPPR--------------------------- ---HAQPP----SLSAPGAKE--------PQENGLPA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EDIESLAAGLVTGVISAAAREV-------------------------------------- --------------------------LA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E--------------------------------- -------GE-------------------------------RD------------------ -EASGGPSEP-------------------------------------------------- S----------------------------------------------------------- -----SST----------------------------------------------P----- ---------VTNGRPFAVQEAMRDASLT-------------------------------- -----------------------------------PVEA--------------------- ------LHP----------SLGERP----------------------------------- --------------------------------------------------AASCAEVETG EGALAG------------------------------------------------------ ------------------------------------------------------------ ----------------LLSQE--------------------------------------- ---------------EGGTATAATE----------------------------------- ----------------------------------------------------------VN GCL--------------------------------------------VWQTPEND----- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HSWTRAENGPESICPAQIREATP --------------------------------------------------PSL------A K----------------------------------------------------------- ------------------------------------------------------LQA-EE AVTL------------------------------AEDSG---CSTCQSEDGIG--GE--D V-LHGAGSVCAGPNGKE------------------------------------------- ---------------------------------------------------------DPR HLSGACGWVPERVAPHPFAHEER------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -SLNDTSLRNGSH-VIETEADQSG----GSDVNSMDSVDSG-CTLGLADGHRGAGSQPPH SQTTELIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQDFQICHIEGT QQQVDKALTLIGKKFKDLDLTNLYAPPPLP-LG---LPSLPMTSW--------------- LMLPNGVTVEVIVVNIVSAGHIFVQQHTHPTYHALRSLDQQMFLCYSQPGTPTLPSPIEV GVICAAPAGEG-AWWRAQVIAYFKDSSEVEIRYVDYGGYDRVKVDTLRQIRSDFVTLPFQ GTEVLMDNLAPLP------------------------GADRFSAEASTALEEITRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSYDSNTGLPFIQMWNMVGDEL------------------------------ -----------------------------VSVNRTLIERGLG-TWLDSF----------- ------------------------------------------------------------ - >ENSAMXP00000028600 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSFVPYTLPGVLALI-GWWWYTSRKKARITSHKSEE---GHAMG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LA---------------SP- ------SEGSN-------------------------GMVDKGC----------------- -----PAASVTHDRSCQDR----------------------------------------- ------------------------------------------------------------ ---------------P------------------------KAKEQRPVEQE--------- -VIAQVHV---------------------------------------------------- ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------AT- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ETSVEEPVCSA VTVTTSRKLGAP--PCSNATTDSHQASTESIRQTTPLSTSTP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SNVVEKCFQYN QPGA--AAVSSESSHLPTEEALGSAMQPQD------------------------------ --------------------------QTTDKRE--------SDS---------------- --------------KKVKPAVVS------------------------------------- ------------------------------------------------------------ -----------------------------------SCVKLAKAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAG--------------NILAVPFAENVQVDLV-KDSL----S CTKDDLSSTTT--AA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------TRTV------------GP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ESPM----------------------- ------------------------------------------------------------ -----------------------------VSV---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SFPLSASTPISNASIEPHHHENGGVSRPAETRDNM EELQRLAAGLITEVISAAKQEV-------------------------------------- --------------------------MAVSSCK--------------------------- -----------------------------------TSEAASSSTPTFNGK---------- -----------------------------------------------------GTTGDED LHVSHVEAPS----QSHT------------------------------------------ ----------------------------------------DDIQ---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------QQAAQIVKEVIN GCL-----------------------------------------SPSVWQKPE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EVPECLVSSRGQLESTPVL------P K----------------------------------------------------------- ------------------------------------------------------LQG-EE TITA------------------------------TEDSG---CSTCQSEDGIS--SE--D L-LLSTGLSSAVPESKEDLIQISGIS-RCSEEKEDGLQES--SDLTELEEPT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------LTREH----------------------VAAVCEA ARLNGTGFRNG---TSEAEADQSG----GSDVNSMDSVDSF-STLGAGDGQL-SGSQASP SQSSELIVWEIEVP-KHLVGRLIGKQGRYVSFLKQSSGAKIYISTLPYTQEFQICHIEGT QQQVDKALALIGKKFKDLDLTNLYAPPPLP-LS---LPSLPMTSW--------------- LLLPNGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVDG-AWWRAQVISFYKDSNEVEIRYVDYGGYDRVKSDTLRQIRSDFVTLPFQ GTEVLLDNVAPLP------------------------GEDRFSSEASSALEEMTRGIPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDNNTGLPLVQMWNMVGEEL------------------------------ -----------------------------VLLNRTLAERGFA-TWVDSF----------- ------------------------------------------------------------ - >ENSPNAP00000001587 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSIVPYIFPGVVALI-GWWWYTSRKKEWITGHNSEE---GQAMG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LA---------------SP- ------GESSN-------------------------GIVDKDC----------------- -----QAISVRHGRTSQER----------------------------------------- ------------------------------------------------------------ ---------------P------------------------KAKEQRPAEQE--------- -VVAQVHA---------------------------------------------------- ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ATK ASSGEPLSSS-------------------AIVEASGKLDSSHSKATTDS---LQSSPEAF RQKP--------------------------------------PV---------------- --------------PTSTSSNVVEKTSHKRPVAAALSDKS-------------------- -------RQLPTVGELDSVRQLQDQTANKQELDTK-EISPAVPWSAELP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KAERPE-----------P- ------------------------------------------------------------ -----E---------GGVAD--------------DILAVAFAENVQADLV-KDSL----S STKDDL------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------PP---- ----------------------------------------------------------KT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------LTVLDQ----------CAQ---------AV FQH---------SFLT-------------------------------------------- ---------------------------------ESPV----------------------- ------------------------------------------------------------ -----------------------------VSA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SFPLSASTPVSDNSIEAKHHENGDVSESAKTSNSM EELHRLATGLITQVITAATQEV-------------------------------------- --------------------------MAVSSCE--------------------------- -----------------------------------ASVATSSITPTFNGKDIMREEEHRE SQVCPSSQSQA-----------------------------NHVEQRTAQTAED------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------VIN GCL-----------------------------------------VPSVWEKSE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------DERQCTLSSQRQLESIPVL------P K----------------------------------------------------------- ------------------------------------------------------IQA-EE AVTG------------------------------TEDSG---CSTCQSEDGIS--SE--D L-LLSTGLSSTVPERKEDLIQISGIS-RSSEEKEDGLQES--SDLTGLEEPT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------LTAEH----------------------VAAVCEV ARLNGAGLRNG---TSEAEADQSG----GSDVNSMDSVDSC-STLGTGDGQQ-SGSQSSQ SQSSELIVWEIEVP-KHLVGRLIGKQGRYVSFLKQSSGAKIYISTLPYTQEFQICHIEGT QQQVDKALALIGKKFKDLDLTNLYAPPPLP-LS---LPSLPMTSW--------------- LLLPNGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVDG-AWWRAQVISFYKDSNEVEIRYVDYGGYDRVKIDTLRQIRSDFVTLPFQ GTEVLLDNIAPLP------------------------GEDRFSTEATSALEEMTRGVPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDNNTGLPLVQMWNMVGDDL------------------------------ -----------------------------VQLNRTLAERGFA-TWVDSF----------- ------------------------------------------------------------ - >ENSDARP00000115383 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSFVPYTLPGVLALI-GWWWYISRKKERITSHDSEE---DSLMG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------SS- ------GEGSN-------------------------GMVDKSC----------------- -----PASSSTHRKTSQDR----------------------------------------- ------------------------------------------------------------ ---------------V------------------------KAKEHRPVEQE--------- -VVAEIHT---------------------------------------------------- ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------VLK ATAGEALGT--------------------------------------------------- ---P--------------------------------------PVVL--------ASGQLS APHSGTKSVPPKSHPETTS----------------------------------------- ------------------------------------------------------------ --------------------------------QTTPVSSSTPTKTVEETPHHKGPDV--- ------------------------------------------------------------ ------ATDARP------------------------------------------------ -------------SSQ---------------LP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PASTDSIKKQVENQTLTSQRS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VELAKAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAT--------------ESLATTCAQNLQADIS-KDEL----A ST---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------ISST--------------------------- ---E-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------SEAVLLETCSPK TPLNL-------------------TSFPNSTSTPLSESSTGAQHHENGDLGLPAETSPDL QELQRLAAGLITEVISAATQEV-------------------------------------- --------------------------MAVSSCESR------YS----------------- -----------KGSEASDDSTLALNGKEESSQLPKSAES--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------RAAQIAEEIVN GCL-----------------------------------------APSLWKMPEN------ ------------EKD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------RGLLSVPSGE----------QLESTPTL------A K----------------------------------------------------------- ------------------------------------------------------LQA-EE AL--------------------------------VEDSG---CSTCQSEDGVS--SE--D --LHSTGLSSTVSESKEDLIQISG---------------------------TCKATEG-- ------------------------------------------------------------ -------------------QEDRLHESLA-------------------------LI---- ------------------------------------------------------------ --------------------APQESPLTAEN----------------------VATVCEA ARLNGTGLRNG--AASEVDADQSG----GSDVNSMDSVDSC-STLGAGDGQL-SASQTCQ SQSSELIVWEIEVP-KHLVGRLIGKQGRYVSFLKQSSGAKIYISTLPYTQEFQICHIEGT QQQVDKALALIGKKFKDLDLTNLYAPPPPP-LT---LPSLPMTSW--------------- LLLPSGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPPLPSPVEV GVICAAPAVDG-AWWRAQVISFYKDSTEVEIRYVDYGGYDRVKIDTLRQIRSDFVTLPFQ GTEVLLDNIAPLP------------------------GEDRFSAEANSALEEMTRGVPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDNNTGLPLVHMWNMVGEEL------------------------------ -----------------------------VLLNRTLAERGFG-TWVDSF----------- ------------------------------------------------------------ - >ENSIPUP00000005293 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSFVPYTLPGVLALI-GWWWYISRKKARLTSHDRDE---EPVAG----- ---V-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LA---------------SP- ------AKGTN-------------------------GMVE-------------------- ---------TTHGRPCLDK----------------------------------------- ------------------------------------------------------------ ---------------P------------------------SAKEPVSAEQE--------- -VVARIYT---------------------------------------------------- ----------------------------------------------------------M- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------AT- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SASVEEPVSSP VVV---KKLGTPPHPCSIATADSQTSSLEVTSEKSPILAMTPSNLVEMSPPHERPDVVVL SNESSQLTAEAELDTSGSLSQSWDQ-----------------------TLDKQETDTKEM APLICQA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VELSKAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAD--------------DVLAVPFAENLQADLA-KDSL----S STKDDLAAAS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MTGDQYTQ-----------------AASQQSLG------------- --------------------------------LDSPL----------------------- ------------------------------------------------------------ -----------------------------VPA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SFPISTSSPVLNDFIQVQNHENGDPCCEVESSDSM VELQRLAAGLITEVILAATQEV-------------------------------------- --------------------------MAVSSSTSQ------LS----------------- -----------EGPEA-------------------------------------------- ----------AFSITSTLNGKEREEDECVSQVDSSSEGCKDHVEQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------HAAQIAKEVIN GCL-----------------------------------------TPSVWEKSETQ----- ---NSFALRDHQE----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------QLESTQIL------P E----------------------------------------------------------- ------------------------------------------------------VQAKEE AVMG------------------------------TEDSG---CSTCQSEDGIS--NE--D L-VISTELSSVVHDCKDDLIQISGIS--TSEEKGDGHQES--SDSAVLEETV-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------LRVEH----------------------ATATCAL AQVNGEAFRNG---TSEAEADQSG----GSDVNSMDSVDSY-SALGTGNDQQ-SGSQA-- SQSSELIVWEIEVP-KHLVGRLIGKQGRYVSFLKQSSGAKIYISTLPYTQEFQICHIEGA QQQVDKALALIGKKFKDLDLTNLYAPPSLP-LS---LPSLPMTSW--------------- LLLPNGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEI GVICAAPAVEG-AWWRAQVISFYKDSNEVEIRYVDYGGYDRVKIDTLRQIRSDFVTLPFQ GTEVLLDNIAPLP------------------------GEDGFSAEANSALEEMTQGLPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDNNTGLPLVQMWNMVGDEV------------------------------ -----------------------------VLLNRTLAERGLA-TWVDSF----------- ------------------------------------------------------------ - >ENSEEEP00000025857 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSFVPYTLPGVLMLI-GWWWYISRKKGRVAGHNSEE---GPAMG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------SP- ------SEGSN-------------------------GVVEKGC----------------- -----PPAGTAHTTILPDV----------------------------------------- ------------------------------------------------------------ ---------------P------------------------DAKEQRPAEQK--------- -VVAPVHA---------------------------------------------------- ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ASR GPAGEP------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PDQPQLAVASGKLGASCYSNSASTDYQP GSPETGRQKAPASASGPADLAEKSSSRKRPEAASLSNEAS-------------------- ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------PA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------AGELGAAA SARQLLDGKPDNREAGAMEKALATCRPTEP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------ARAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAG--------------EVLAVPFAESLQADLV-KDNP----P LTKD-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ERPS----------------------- ------------------------------------------------------------ -----------------------------VPA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ATQEQRAQGGSCQSPSTAAPTLFPLSASAPDMDVPVETQHHENGDLCQSAETTGGM EELHRLAAGLITEVLSAATQEV-------------------------------------- --------------------------MTVGS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RDLQ------------LGES TEV------A-------------------------------------------------- G----------------------------------------------------------- -----CST----------------------------------------------P----- ---------TLNG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------QE--------------------------------------- --------------------TARQQLQWAS------------------------------ -------------------------------------------QSQADQHAAQLAEDVAN GCL-----------------------------------------PSSAWEKPE------- --------------DDR------------------------------------------- ------------------------------------------------------------ -------------------------------------H------GGP---------RAAP I------------------------RG------------------QLHSTPLL------P R----------------------------------------------------------- ------------------------------------------------------VQA-VE AVTT------------------------------TEDSG---CSTGQSEDGVS--SE--D LVLLGTSSPSALPQSKEDLAQISGIS-RSSEGKADELPDSSVSDLVALEQPT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------LTTEH----------------------VAAVCEA ARLNGAGLRNG---TSETEADQSG----GSDVNSMDSMDSC-STLGVGDGQQ-SGSQASQ SQSSEMIVWEIEVP-KHLVGRLIGKQGRYVSFLKQSSGAKIYISTLPYTQEFQICHLEGT QQQVDKALALIGKKFKDLDLTNLYAPPP-S-LS---LPSLPMTSW--------------- LLLPNGVTVEVIVVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPAEV GVICAAPAVEG-AWWRAQVISFYKDSSEVEIRYVDYGGYDRVKIDTLRQIRSDFVTLPFQ GTEVLLDNIAPLP------------------------GEDRFSSEANSAMEEMTQGVPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDNNTGLPLVQMWNMVGDEL------------------------------ -----------------------------VQLNRTLAERGFA-IWVDSF----------- ------------------------------------------------------------ - >ENSDCDP00000039524 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSFAPYTLPGVLALI-GWWWYVSRKKARIGG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AGGGIESDDGKAPGLGSP- ------SEGSN-------------------------GMVEKSC----------------- -----PP--SVHHRTGRDR----------------------------------------- ------------------------------------------------------------ ---------------P------------------------KAREQRPAEQA--------- -VEAQVHV---------------------------------------------------- ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------AA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -APET-------------------------------LAAA-------------------- ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------PSE---RTQSGPEQLTEDSPEPVQHHPALKDGGAPQAPG-----PASIS-- ------------------------------------------------------------ -----------------------------------------------------------S EAV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------EVS--------------- ------------------GEEEVRRSAAAEGSGAAELHVSRTAGVEEAVAAVA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VELAKAERPE-----------P- ------------------------------------------------------------ -----E---------GEVAA--------------DVAAPP--ENLQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VAKDSP-------APS---- ----------------------------------------------------------PT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LTKD------------------------------------------ ---------------------------------EPPA----------------------- ------------------------------------------------------------ -----------------------------EPPR--------------------------- ---QDSPPLRPETLETSGARD-------------LP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------RAED-------- ------------------------------------------------GEA--------- ------------------------------------------------------------ EALEQLAAGLISEVITAATREF-------------------------------------- --------------------------RTAGGCES-------------------------- ---------------------------------P-------------------------- ----PTADRPA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ G----------------------------------------------------------- -----SST----------------------------------------------P----- ---------LVNGRP--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --RLSSDA---------------RSEDGAW------------------------------ --------------------------HSP------------------------------- -------------SQLLVTQE--------------------------------------- --------------------SAA------------------------------------- ------------------------------------------------------SPEVPN GCP-----------------------------------------AAPAWETSENGTRTDT VVGSRF------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GQAEVSPVL------S K----------------------------------------------------------- ------------------------------------------------------LRS-EE GAAG------------------------------PEDSG---CSTCQSEDGVS--GE--D L-LHSTGLSQSMPDSRGDLIRVSGIS--LQAESEGGEEES-------------------- ------------------------------------------------------------ ----------------------------ARKSPAPVPLEEETLAKHTAETNADDL----- ------------------------------------------------------------ ------------------------------------------------------------ -QVNGTALRNGAHAPSEAEADQSG----GSDVNSMDSVDSG-CTLGAGEGQQ-RGSHAQA SQSSELVVWEIEVP-KHLVGRLIGKQGRYVSFLKQSSGAKIYISTLPYTQEFQICHIEGT QQQVDKALSLIGKKFKDLDLTNLYAPPPLP-LT---LPSLPMTSW--------------- LLLPTGVTVEVIVVNIVSPGHMFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPSPTEV GVICAAPAMDGAAWWRAQVISFLKDSNEVEIRYVDYGGYDRVKIDTLRQIRSDFVTLPFQ GTEVLLDNLAPLP------------------------GEDRFSTEGNAALEEMTRGVPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDNNTGLPMVQMWNMVGDEL------------------------------ -----------------------------VLLNRTLAERGFG-SWVDSF----------- ------------------------------------------------------------ - >ENSLOCP00000005638 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRSFFPYTLPGVLALI-GWWWYTSRKKGRLAERTKEE---AAGAGTVLPE ACRL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------PA---------------PS- ------GEGSN-------------------------GIVEKSC----------------- -----P------------------------------------------------------ ------------------------------------------------------------ -------------------------------RQASDRKPQKSKKDAAEEQE--------- -VVAEVHT---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------V MAEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AKE--E---------------------------------- ------------------------------------------------------------ ---------------GPV------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------PS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SETLGASLAPSDESRAVPRLLEAAFPHRPKTAEQSLLLQGPG EAGLSAGAPLLEGMQVATAFISAPGKQTTKKDEGKAAVLPASRS---------------- --------------KETK---IS------------------------------------- ------------------------------------------------------------ -----------------------------------SAAELAEAVRPE-----------P- ------------------------------------------------------------ -----E---------GEVAA--------------DKIAVPFAEELQPGAA-KESL----S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------K-------AP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CSEIPAAFVSSCHV A----------------------------------------------------------- ---------------------------------STPA----------------------- ------------------------------------------------------------ -----------------------------QPP---------------------------- ------------KPGAEGAPEAEGY--SRPQENGLPA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GL------------------------------ ------------------------------------------------------------ -----------------------------------------------------AERRGSI DELERLAAGLITEVISAAAQEV-------------------------------------- --------------------------TLVG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RR------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GDAGNGQGCGAAVGEQHSRSA---------------------------------- ------------------------------------------------------------ -------------------QE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------DGETGGSCLANENGISGNSSRWRAERGQKSHSVGLAE--------- ------------------------------------------------------------ -----------------------------------GKK------------------EAVP --------------------------------------------------QSL------V R----------------------------------------------------------- ------------------------------------------------------LQV-EE LAAG------------------------------AEDSG---CSTCQSEDGIS--SE--D L-LQGTGLSCVVPESKEDLL---------------------------------------- ------------------------------------------------------------ ----------------------------------------------------NDLVVEVA SEGQCTGSGSSS------------------------------------------------ -------EQSPAAAVLPTHRT-----------------------------------TCAG RGLNGSSLRNGGHWTNEAEGDHSG----GSDVNSMDSVDSG-CTLGAGEAKR-GTGQPPH PQKSELTIWEIEVP-KHLVGRLIGKQGRYVSFLKQSSGAKIYISTLPYTQEFQICHIEGT QQQVDKALGLIGKKFKDLDLTNLYAPPPLP-LT---LPSLPITSW--------------- LMLPSGVTVEVIVVNIVSAGHMFVQQHTHPTYHALRSLDQQMFLCYSQPGIPTLPSPVEV GVICAAPAVEG-AWWRAQVIAFYKDSNEVEIRYVDYGGYERVKIDLLRQIRSDFVTLPFQ GAEVLLDNIAPLP------------------------GEDRFSTEADSALEEMTRGVALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSSTGLPLIQLWNMVGDEL------------------------------ -----------------------------ASVNRALVERGLG-TWIENF----------- ------------------------------------------------------------ - >ENSCHAP00000056842 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MPLRFRSFAPYTLPGVLALI-GWWWYISRKKARPASLQAEEEGAAPAMG----- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LS---------------SP- ------TEVSN-------------------------GLLERACCQP-------------- -----TSTSTVHRRPSRDR----------------------------------------- ------------------------------------------------------------ ---------------P------------------------KTIEPKSTEQELLLQQEVVV VVAAQVHS---------------------------------------------------- ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVR AVEAEA------------------------------------------------------ ------------------------------------------------------------ --------------------------------------ESISISRSPSLGLGRTEVPQVS TPHLRKGREAPT-------------------------------------QSSVE------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------CQQKTTEADLATEKSSSESERDALSCSDA QQIHVDTGKPS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --VTPLITAEPTAAKEMSPDVDSEALRLAATH---------------------------- ----------SDR-MDP--------------------------------------D---- -----------------------------------------VE----------------- ---------------------------------------------------VA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VELTKDARPE-----------P- ------------------------------------------------------------ -----E---------GEVAA--------------E------------------------- --------------ET-------------------------------------------- ----------------------------------P------------------------- -----------------H------------------------------------------ ----------TQPAPKTLH-ETLRDATPYPSSSSSISTSSITKEEP-------AP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MT-----------------------LAAKESR-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QEPPFLHPET----------------------PT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------AHHVTSPLFTS TPTGPDEATSE----------------------------------G-------------- ------------------------------------------------------------ ------QDQ----------------------WQV-------------------------- ------------------------------------------------------------ --------------------E------NGI---------------VSQLRED-------- ------------------------------------------------GES--------- -------KHVAQ----------------------------------------------QL QEYERVAAGLITEVISAAAQQV-------------------------------------- --------------------------QMTGSCE--------------------------- -----------------------------------DVAVAVQTTP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ S----------------------------------------------------------- -----QTT----------------------------------------------P----- ---------VPNGRPCSA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------DSSG----------------------------------------------- ------------------------------------------------------------ -------------------QE--------------------------------------- --------------------VAANE--EASMQETQTQGP--------------------- ----------------P-----------------------ATEQSD---------KEMTN GCL-----------------------------------------TAPTWE---------- --------------------------------------------------RYAERMAEKE QTTVTTTPSDSLRE---------------------------------------------- ---------------------------------PAGSH---------------------- -----------------------------------------------------------S K----------------------------------------------------------- ------------------------------------------------------LQA-DE TQTV------------------------------AEDSG---C--CQSEDGIS--GE--D LPLHATGLPQVAPDTKE----------------------------------------GPV QASSSSLLSSKIEEVRPTG----------------------------------------- -------------------------------SPTPVVLEEAVLA---------------- ------------------------------------------------------------ -----------------------------QH----------------------EAATALR PQLTAASLRNGAHLISEAETDQS-----GSDVNSMDSVDSG-CTLGAGEG---SSSLPSA SSSSEVIVWEIEVP-KHLVGRLIGKQGRYVSFLKQSSGAKIYISTLPYTQEFQICHMEGT QQQVDKALALIGKKFKDLDLTNLYAPPPAP-LT---LPSLPMTSW--------------- LLLPNGVTVEVIVVNIVSPGHMFVQQHTHPTYHALRSLDQQMFLCYSQPGTPALPTPIEV GVICAAPAGEG-AWWRAQVISFYKDSNEVEIRYVDYGGYERVKIDTLRQIRSDFVTLPFQ GTEVLLDNLLPLP------------------------GEDRFSTEGNAALEEMTRGVPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDNNTGLPMVQMWNMVGDEL------------------------------ -----------------------------VLLNRTLAERGFG-NWVDNF----------- ------------------------------------------------------------ - >ENSVURP00010017732 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MTIQFRAVFPLALPGVLALI-GWWWFFSRKKEHVSSHDR-Q---------AGAT AKDL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------DTP VEES-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LLREEVY------------------- ----------YTRVVPL------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------PS D----------------------------------------------------------- -----------------GSRP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------S----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEIVTMGKSSME ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LVTIPSQP-------HLVPRKSDSSTTL- ------------------------------------------------------------ ---------SGTTDTKLR----------------------------LS-S---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RK-EDSGK -----------------------------------------LEKAASQE----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETRS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------KESSLPPLKDALFPHEAIELQ-KQDSPFSQISGKGWPGHLEVPSEQ HGP------------LEKV----------------------------------------- -------------KETSGIEGTGDAAMGESVSEEGDLS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------HDLGSESKTRVPRQDAMMEEEKRKEKGRCQGVRSV------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------QKEE C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------L-------- ----GKVLNSFIESTQAELSQEEEALAHQVRG---------------------------- ------------------------------------------------------------ --------------------------------SRSGEGYLDGDH---------------- ----------------------------------LVGELKKGS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------SLEIR--------- ------------------------------------------------------------ EDFEQAAMQIISKVILAAKEEI-------------------------------------- --------------------------LGKTVGDL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------KQH-NCEP---------------------------- ----------------------------------SVSWVEGPVEEESFALASQKLVLEQ- ------------NSSDPSRAEIEA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ---------MAAGE-------------TVELDVA-------------------------- ------------------------------------------------------------ -----------------------SPPSG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PQME-------------DLA------------ ------HKQKTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------KNSL MSSAA-LD------------------------------------------------GK-P KNSAQRISLAACPP---------------------------------------------- ---------------------QA-IHHSE-------------------SF--------EE ASIR------------------------------VEDAS---CVTCMSEDSQR--AQ--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVS SSGNCSDSAVTSGL----------EDSSLEPNLSPSNK-LLTPPLLE-RTVSYSNGVLKG ESSDLGTEDRW------------------------------------------------- --------------TTETEADQSG----GSDVNSMDSVDSG-CGLRKTESHP-SSQAGTE TNKVELTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNFQICHIEGS QHHVDKALSLIGKKFKELNLTNIYAPPLPS-LT---LPSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHMFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEV AVICAAPGVDG-AWWRAQVVAYYKESDEVEIRYVDYGGYKRVKTEILRQIRSDFVTLPFQ GAEVLLDNVTPLS------------------------DEDHFSPEADAAVNEMTRGTPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNY-NSTGLPLIQLWSMIGDEA------------------------------ -----------------------------VSINRTLVERGLA-QWIDSYYTSL------- ------------------------------------------------------------ - >ENSPCIP00000007107 MT---------------------------------------------------------- -------------PP--------------------------------------------- ---------------------------------QSNLERLLVTSGTGTEPLKGYLVLVCA VYVYNY---------------------------RISR----------------------- ------MTIQFRAIFPLALPGVLALI-GWWWFFSRKKEHVSSRDR-Q---------AGAT AKDL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------DTP IEES-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LLREEVY------------------- ----------YTRVVPL------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------PS N----------------------------------------------------------- -----------------GSQP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------D----------------------KEIVTMGKSSVE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LVTIPSQP-------HLVPRKSDSSTTS- ------------------------------------------------------------ ---------SGTTDAKLR----------------------------LS-S---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RK-EDSGR -----------------------------------------LEKAASQQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETRS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------KESSLPPLKDALFPHEAIELQ-KQDSPFSQISGKGWPGHLEVPSEQ HGP------------LEKV----------------------------------------- -------------KETSGIEGTGDAAMGESVSEEGGLS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------HDLGSESKNRVPRQDAMMEEEKGKEKGRSQGVRSV------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------QKEE C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------L-------- ----GKVLNSFIESTQAELSQEEEALAHQVRG---------------------------- ------------------------------------------------------------ --------------------------------SRSGEGYLDGD----------------- ----------------------------------LVGELKKRS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------SLEIR--------- ------------------------------------------------------------ EDFEQAAMQIISKVILAAKEEV-------------------------------------- --------------------------LGKTAGDL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------KQH-NCQP---------------------------- ----------------------------------SVSWVEGPVEEESFALGSQKPVLEQ- ------------NSSDPSRAVIEA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ---------MAAGE-------------TVELDIA-------------------------- ------------------------------------------------------------ -----------------------SPPPG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PQME-------------DFT------------ ------HKQKTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------KNSL VSSAA-LD------------------------------------------------GK-P KNSAQRISLAACPP---------------------------------------------- ---------------------QAIIHHSE-------------------SF--------EE ANIR------------------------------VEDTS---CVTCMSEDNQR--AQ--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVS SSGNCSDSAVTSGL----------EDSSLESNLSPSNK-LLTPPLLE-RTVSYSNGVLKG ESSDLGTEDRW------------------------------------------------- --------------TTETEADQSG----GSDVNSMDSVDSG-CGLRKTESHP-SSQAGTE TNKVELTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNFQICHIEGS QHHVDKALSLIGKKFKELNLTNIYAPPLPS-LT---LPSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHMFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEV AVICAAPGVDG-AWWRAQVVAYYKESDEVEIRYVDYGGYKRVKTEILRQIRSDFVTLPFQ GAEVLLDNVAPLS------------------------DEDHFSPEADSAVNEMTRGTPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNY-NSTGLPLIQLWSMIGDEA------------------------------ -----------------------------VSINRTLVERGLA-QWIDSYYTSL------- ------------------------------------------------------------ - >ENSSHAP00000015580 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRAIFPLALPGVLALI-GWWWFYSRKKEHVSSHDR-Q---------TGAT AKDL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------DTP IEES-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LLREKVC------------------- ----------YTRVMPL------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------PS D----------------------------------------------------------- -----------------GSRH--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEMVTMGKSPME ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LVRKTSQP-------HLPPRKLDSSGTF- ------------------------------------------------------------ ---------SGTTDAKLR----------------------------LN-S---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RK-EDGGK -----------------------------------------LEKAVSQE----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETRS--L-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------KESSLPPLKDALFPHEALELQ-KLDSPFGRIPGKGWPGHLEVPSEQ HGS------------LEKA----------------------------------------- -------------KEASGIEGTGDAAMGESVSEEGGLS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YNLGAESKIRVPKQDTMMEEEKGKEN-RSRGVRAV------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------QKEE C----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------L-------- ----GKVLNSFIESAQAELSQEEQAVAHQVRS---------------------------- ------------------------------------------------------------ --------------------------------NRSGENYIDGGH---------------- ----------------------------------LTRELKKGS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------SLEMR--------- ------------------------------------------------------------ EDFEQAAMQIISKVILAAKEEL-------------------------------------- --------------------------LGKTVGDL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------KQH-NCQP---------------------------- ----------------------------------SVSWIEGPVEEQSFVLDMQKPVLGQ- ------------NASDPSRAVVDT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ---------MASGK-------------TVELEVV-------------------------- ------------------------------------------------------------ -----------------------GLPPG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PEVE-------------DLG------------ ------HKQKTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------KNSL LSSVA-LD------------------------------------------------DK-P KNSAQRISLAAGSP---------------------------------------------- ---------------------QA-VQYSE-------------------SF--------EE ANIR------------------------------VEDTS---CVSCMSEDSQR--AQ--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVS S--NCSDSAGTSGL----------EDSSSELNLSLSNK-PLTSPLLE-RTVSYSNGVLKG ESSDLGTEDRW------------------------------------------------- --------------TTETEADQSG----GSDVNSMDSVDSG-CGLRKTESHP-SPQPGTE TNKVELTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNFQICHIEGS QHHVDKALSLIGKKFKELNLTNIYAPPLPS-LT---LPSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHMFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEV AVICAAPGVDG-AWWRAQVVAYYKESDEVEIRYVDYGGYKRVKTEILRQIRSDFVTLPFQ GAEVLLDNVAPLS------------------------DEDHFSPEADAAVNEMTRGTPLL A-----------QVV--------------------------------------------- ------------------------------------------------------------ --------TNY-NSTGLPLIQLWSMIGDEA------------------------------ -----------------------------VSINRTLVERGLA-QWIDSYYTSL------- ------------------------------------------------------------ - >ENSMODP00000018504 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRAIFPLALPGVLALV-GWWWFFSRKKEHVSSRDR-Q---------AVAA AKDL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RT---------------DTP IEES-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LLREEVC------------------- ----------YTRVVPL------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------PS D----------------------------------------------------------- -----------------GSRP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEIVTMGKNSVE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LVTKPSQA-------YPVPRKSDSTSTF- ------------------------------------------------------------ ---------PVTTDPKLQ----------------------------MG-V---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RK-ED-GK -----------------------------------------LEKAASQQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETRS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------T- --------------KEPSLPPLKDAVFPHEAIELQ-KQESLFSLTPGKGWPDHLEAPSEQ HGP------------LEKI----------------------------------------- -------------KETSGIEGTGDAAPGENMSEEGGLS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------HDLRFESRNRLPSQDTVMEEEKGKES-RSRLVRTV------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------QKEE Y----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------L-------- ----GKVLNSFIASSQAELSQEEEALTHQVRG---------------------------- ------------------------------------------------------------ --------------------------------SRSG-GFLDGDH---------------- ----------------------------------LAGELKKGSPLEIREEKGSPLEIREE --------KGSPLEIREEKGRSLLEI---------------------------------- ------------------------------------------------------------ -------------------REEK------------------------------------- ---------------------------------------------GSLEIR--------- ------------------------------------------------------------ EDIEQAAMQIISKVILAAKEEM-------------------------------------- --------------------------LGKTVGSL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------KQH-NCQPLK-------------------------- YQPETCLGEEEEEEEVEEEEEEEEKEENLIHEQVS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------YVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TNSL MSRAA-LD------------------------------------------------DK-P KNSAHRFSLAACPP---------------------------------------------- ---------------------QA-VHHSE-------------------SF--------EE ANIR------------------------------VEDTS---CVTCMSEDSQR--AQ--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVS SSGHSSDSAGTSGL----------EESSMEPNLSPSNN-PLTSPLLE-RTVSYSNGVLKG ESSDLGTEDRW------------------------------------------------- --------------TTETEADQSG----GSDVNSMDSVDSG-CGLRKTESHS-SSQAGTE SNKVELTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNFQICHIEGS QHHVDKALSLIGKKFKELNLTNIYAPPLPS-LT---LPSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHMFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEV AVICAAPGLDG-AWWRAQVVAYYKESDEVEIRYVDYGGYKRVKTEILRQIRSDFVTLPFQ GAEVLLDNVAPLS------------------------DEDHFSPEADAAVSEMTRGTPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNY-NSTGLPLIQLWSMIGEEA------------------------------ -----------------------------VSINRTLVERGLA-QWIDSYYTSL------- ------------------------------------------------------------ - >ENSVVUP00000015964 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLAVL-GWWWFFSRKK-HVSSQDR-Q---------VEAS AVEL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------SHA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LSMEDPC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVATS-PS IILS--------------------------------------A----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEPSTVSKPPME ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AMLRPHLTCRRSESSGSL- ------------------------------------------------------------ ---------PNTTDPRFR----------------------------PGGT---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LR-DDSAK -----------------------------------------VELALTGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EARS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLPAPKGVPFPHEAAEVC-KQESPFNGTGGLSWQGQAAAL--- ---------------QEKP----------------------------------------- -------------RETNGAEGTGDAVLGENVLEEGVLFQEH------------------- ---------DSESEI--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPSP-----APL-GGA GEKGKGS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------VE EDAAGKLLSSLIESAHTEL----------------------------------------- ------------------------------------------------------------ --------------MENDELLAPRVSSRACD----------------------------- -------------------------ADSM-------GELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------EVVEQD--------- ------------------------------------------------------------ EKIEQAAYQIISRVILEATEEV-------------------------------------- --------------------------LATTMGRIAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVHQASAGQLQGQKEE-SCVPVC-------------------------- ----------------------------------------------------QKTALGQ- ------------DAAEPTPATVEVVEAVKVAETVTEAVAEAVAIS--------------- ------------------------------------------------------------ ------------GQSD--------------------------------------P----- ------------------------------------------------------------ ------------------ALPLPDL----------PTED--------------------- -----------------------LPSP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYMS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------RK-P KNSAHHISLAPSPS---------------------------------------------- ---------------------PA-LPQGE-------------------SP--------DE ASVL------------------------------VGNAG---CITCTSDNSQD--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SE-QCSDSVSTSGL----------EDLCTDTNSSPRGQ-TISPPLPE-STVPFSNGVLKG ELSDLGNEDGW------------------------------------------------- --------------TVEAEADHSG----GSDGNSMDSVDGC-CGPRKTDSFQ-NAQAASS PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVASYEESNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGNEA------------------------------ -----------------------------VLINRSLVERGLA-QW--------IHWRTKG TQDFSTPHIFCKQMLLLQSTAAPASSSCGFLNTGQGIRLASALCHIRK------------ - >ENSCAFP00020032980 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLAVL-GWWWFFSRKK-HVSSQDR-Q---------VEAS AVEL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------SHA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LSMEDPC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVATS-PS IILS--------------------------------------A----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEPSTVSKPPME ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AMLRPHLTCRRSESSGSL- ------------------------------------------------------------ ---------PNTTDPRFR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LR-DDSAK -----------------------------------------VELALTGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EARS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLPTPKGVPFPHEAAEVC-KRESPFNGTGGLSWQGQAAAL--- ---------------QEKP----------------------------------------- -------------RETNGAEGTGDAVLGENVLEEGVLFQEH------------------- ---------DSESEI--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPSP-----APL-GGA GEKGKGS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------VE EDAAGKLLSSLIESAHTEL----------------------------------------- ------------------------------------------------------------ --------------MEDDELLAPRVSSRACD----------------------------- -------------------------ADSM-------GELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------EAVEQD--------- ------------------------------------------------------------ EKIEQAAYQIISRVILEATEEV-------------------------------------- --------------------------LATTMGRIAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVHQASAGQLQGQNEE-SCVPVC-------------------------- ----------------------------------------------------QKTALGQ- ------------DAAEPTPAIAEVVEAEKVVETVTEAMAEAVVIS--------------- ------------------------------------------------------------ ------------GQSD--------------------------------------P----- ------------------------------------------------------------ ------------------ALPLPDL----------PTED--------------------- -----------------------LPSP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYMS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------RK-P KNSAHHISLAPSPS---------------------------------------------- ---------------------PA-LPQGE-------------------SP--------DE ASVL------------------------------VGNAG---CITCTSDNSQD--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SE-QCSDSVSTSGL----------EDLCTDTNSSPRGQ-TISPPLPE-STVPFSNGVLKG ELSDLGNEDGW------------------------------------------------- --------------TVEAEADHSG----GSDGNSMDSVDGC-CGPRKTDSFQ-NAQAASS PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVASYEESNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGNEA------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSCAFP00000025662 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLAVL-GWWWFFSRKK-HVSSQDR-Q---------VEAS AVEL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------SHA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LSMEDPC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVATS-PS IILS--------------------------------------A----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEPSTVSKPPME ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AMLRPHLTCRRSESSGSL- ------------------------------------------------------------ ---------PNTTDPRFR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LR-DDSAK -----------------------------------------VELALTGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EARS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLPTPKGVPFPHEAAEVC-KRESPFNGTGGLSWQGQAAAL--- ---------------QEKP----------------------------------------- -------------RETNGAEGTGDAVLGENVLEEGVLFQEH------------------- ---------DSESEI--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPSP-----APL-GGA GEKGKGS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------VE EDAAGKLLSSLIESAHTEL----------------------------------------- ------------------------------------------------------------ --------------MEDDELLAPRVSSRACD----------------------------- -------------------------ADSM-------GELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------EAVEQD--------- ------------------------------------------------------------ EKIEQAAYQIISRVILEATEEV-------------------------------------- --------------------------LATTMGRIAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVHQASAGQLQGQNEE-SCVPVC-------------------------- ----------------------------------------------------QKTALGQ- ------------DAAEPTPAIAEVVEAEKVVETVTEAMAEAVVIS--------------- ------------------------------------------------------------ ------------GQSD--------------------------------------P----- ------------------------------------------------------------ ------------------ALPLPDL----------PTED--------------------- -----------------------LPSP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYMS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------RK-P KNSAHHISLAPSPS---------------------------------------------- ---------------------PA-LPQGE-------------------SP--------DE ASVL------------------------------VGNAG---CITCTSDNSQD--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SE-QCSDSVSTSGL----------EDLCTDTNSSPRGQ-TISPPLPE-STVPFSNGVLKG ELSDLGNEDGW------------------------------------------------- --------------TVEAEADHSG----GSDGNSMDSVDGC-CGPRKTDSFQ-NAQAASS PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVASYEESNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGNEA------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSMPUP00000015270 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLAVL-GWWWFFSRKK-HVSSQDR-Q---------VEAG AVER-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------GCA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------RAREDPC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSPP-PS IGAL--------------------------------------A----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEPSAVSKPPSE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRPHASCRRSESSGSL- ------------------------------------------------------------ ---------PNITDTRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DDSAK -----------------------------------------VELALTGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAGS--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------PECPLPTPKNVPFPHVATEVC-KQEALFSATGGRGWQGQAAAP--- ---------------QEKP----------------------------------------- -------------RETGGAEGTGD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AVSGESLPEESVLYQEHDSDS EICKA------------------------------PS----------------------- -----------------------------------------------------PGEKRQD -----------------------------RPPQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TE DDAVGKLLSSLIESAHAEL----------------------------------------- ------------------------------------------------------------ --------------MEDDELRAPQVGDRAGD----------------------------- -------------------------ADGA-------GGPG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------EAVEQN--------- ------------------------------------------------------------ EKIEQAAYQIISRVILEATEEV-------------------------------------- --------------------------LATTVGRITD------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVYQASAGQLQGQKEE-SSGPVC-------------------------- ----------------------------------------------------QKSSPGQ- ------------DAGEPAPATVE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PE---- ------------------------------------------------------------ -----------AASGADATLPSPGL----------PTED--------------------- -----------------------LPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYKS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------RK-P KNSAHHISLAPCPL---------------------------------------------- ---------------------PA-VPQGE-------------------SP--------DE ASVL------------------------------VQNAGCVPCVPCTSDSGQD--VR--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SE-QCSDSTSTSGL----------EDLCTDTNSSPRSK-AISPPLPE-STVPFSNGVLKG ELSDLGNEDGW------------------------------------------------- --------------TVDAEADHSG----GSDGNSMDSVDGC-CGPRKTDSFQ-NAQVGSS PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMCLCYSQPGIPTLPTPVEV TVICAAPGVDG-AWWRAQVVASYEESNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGNEA------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSNVIP00000015785 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLAVL-GWWWFFSRKK-HVSSQDR-Q---------VEAG TVER-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------GRA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------RAREDPC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSPP-PS IRAP--------------------------------------A----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEPSAVSKPPSE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRPHASCRRSESSGSL- ------------------------------------------------------------ ---------PNTTDTRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DDSAK -----------------------------------------VELALTGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAGS--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------PECPLPTPKNVPFPHVATEVR-KQEALFSATGGRGWQGQAAAP--- ---------------QEKP----------------------------------------- -------------RETGGAEGTGD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AVSGESLPEEGVLYQEHGSDL EIRRA------------------------------PG----------------------- -----------------------------------------------------PGEKRQD -----------------------------GPPQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TE EDAVGKLLSSLIESAHAEL----------------------------------------- ------------------------------------------------------------ --------------MEDDELRAPRVGDRAGD----------------------------- -------------------------ADGA-------GGPG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------EAVEQN--------- ------------------------------------------------------------ EKIEQAAYQIISRVIVEATEEV-------------------------------------- --------------------------LATTVGRIAD------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVYQASAGQLQGQKEE-SSGPVC-------------------------- ----------------------------------------------------QKSSPGQ- ------------DAGEPAPATME------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PE---- ------------------------------------------------------------ -----------ATSGADAALPSPGL----------PIED--------------------- -----------------------LPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYKS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------RK-P KNSAHHISLAPCPL---------------------------------------------- ---------------------PA-VPQGE-------------------SP--------DE ASVL------------------------------VQNAGCVPCVPCTSDSGQN--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SE-QCSDSTSTSGL----------EDLCTDTNSSPRSK-AISPPLPE-STVPFSNGVLKG ELSDLGNEDGW------------------------------------------------- --------------TVDAEADHSG----GSDGNSMDSVDGC-CGPRKTDSFQ-SAQVGSS PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMCLCYSQPGIPTLPTPVEV TVICAAPGVDG-AWWRAQVVASYEESNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGNEA------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSAMEP00000002844 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QASR----------------------- ------MAIQFRSLFPLALPGMLAVL-GWWWFFSRKK-HVSSQDR-Q---------VEAS AVEL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------GRA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------RPRADPC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSAP-PS LVLQ--------------------------------------A----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEPSTGSKPPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRPHPICRRSESSGSL- ------------------------------------------------------------ ---------PNTTDPRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DDSAK -----------------------------------------VELALTRD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAGS--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLPAPKSVPFPHEAAEVC-KREPPFGATGGRSWQGQAAAP--- ---------------QEKP----------------------------------------- -------------RETGGAEGTGDALSEESMLEEGVLSQEH------------------- ---------DSEPGI--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SEAPSP-----APS-GGA GEKGKDSPTQAEED-------------------------------AVGKLLSGLMESAHT -------------------ELMEDEE---------------------RLAPRV------- --------------------------------------RGRARDA--------------- ------------------------------------------------------------ ----------------------------DCTGEPGQDEVA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------EQN--------- ------------------------------------------------------------ EKIEQAAYQIISRVILEATEEV-------------------------------------- --------------------------LATTMGRIAD------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVYQASAGQLPGQKEE-SCVPVC-------------------------- ----------------------------------------------------QKTAPGR- ------------DAGEPALATVE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PE---- ------------------------------------------------------------ -----------AASGADAALRSPDL----------PADG--------------------- -----------------------LPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYRS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPS-KD------------------------------------------------RK-P KNSAHHISLAPCPL---------------------------------------------- ---------------------PA-APQGG-------------------SL--------DE ASVL------------------------------AEKAG---CTPCTSDNSRD--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SE-PCSDSISTSGL----------EDSCTDTSSSPRSK-AISPPLPE-STVLFSNGVLKG ELSDLGNEDGW------------------------------------------------- --------------TVDAEADHSG----GSDGNSMDSVDGC-CGPRKTDSFQ-NAQAGSS PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVASYEESNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS-----------------------EDDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGNEA------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSFCAP00000006348 MS------------------------LC---------SSGLGKHVGERPRRSGAGRLGPG VGGRRRRRRARTLPPDCRGGLGHENIPVCGNWQPN----------SCLLSSQDTCLTLGP RSSVGQWQ------------RVAATDPLKKKV---------------------------- ------------------------------SFLQASR----------------------- ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKK-HVSSQDR-Q---------VEAS TVEL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------GHA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDPR------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VASTP-PS VALP--------------------------------------A----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTLSQPPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPACRRSESSGSL- ------------------------------------------------------------ ---------PNSTDVRFR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DDSTK -----------------------------------------VELALTGDE---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------PECPLLTPKGVPFPHEAAEAC-KQESPFSGPAGRGGQGQAAAP--- ---------------QEKP----------------------------------------- -------------RETGGAEGTGDAVSAENVPEESVLCQER------------------- ---------GSGSQT--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKLPTL-----APL-GGS GEKGKGR----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AE EDAAGQLLSSLVGSAHVEL----------------------------------------- ------------------------------------------------------------ --------------TEDGEPPVPRASGRACDAHRTG-------EPGTG------------ -----------------------GAA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------EQN--------- ------------------------------------------------------------ EKIEQAAYQIISKVILEATEEV-------------------------------------- --------------------------LATTMGRIAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVYQASAGQLHGQKEG-SRAPAC-------------------------- ----------------------------------------------------QKTAPGR- ------------EAEEPAPAAME---------------------AEAA---------SRV S----------------------------------------------------------- VSES-DATLLLPG-----------------------------------------P----- ------------------------------------------------------------ -----------------------------------PAED--------------------- -----------------------LPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYAS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPS-KE------------------------------------------------KK-P KNSAHHISLAPCPL---------------------------------------------- ---------------------PA-IPQGE-------------------LL--------DG ARVL------------------------------VEDTG---CVTCTSDSSQN--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVV SE-QCSDSISVSGL----------EDLCTDTNSSPRDK-AITPLLPE-STVPFSNGVLKG ELSDLGNEDGW------------------------------------------------- --------------TADAEADHSG----GSDRNSMDSVDGC-CGPRKTDGFQ-NAQAGSS PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVASYEESNEVEIRYVDYGGYKRVKVDALRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGNEA------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSRROP00000002767 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQLRSLFPLALPGMLALL-GWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DSA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSTP-LS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPPHRRSESSGSL- ------------------------------------------------------------ ---------PNTIDVRFR----------------------------PG-P---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------HR-DNSAK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGVLFPHKSAEVC-KQESPFSRVPGRGQPGSPAAPPEK HGS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGEKMLEEGLLSQEH------------------- ---------VVELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPNL-----ASL-EGE EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQ-VGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIESAHTELPKDDA------------------------------------ -----------APAPPITDGK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRDVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE-----------------------------ESLDRN-E-S LDRNEEGL-------------------DRNEEGLDRNGEGLDRNGEGLDRN--------- ------------------------------------------------------------ EEIEQAAFQIISQVISEASEQV-------------------------------------- --------------------------LATAVGKVAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CVYQ--ASQLQGQEEE-SCVPVH-------------------------- ----------------------------------------------------QQTVLGS- ------------HTGEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------IAEAAAA----------P----- ------------------------------------------------------------ ---------------SDAALPSPGL----------PAEG--------------------- -----------------------SAPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSSPI-KD------------------------------------------------SK-P KISAHHISLAPCLP---------------------------------------------- ---------------------PT-TPGEE-------------------SP--------DR AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSLSTSGL----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDVEADHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSRBIP00000018249 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQLRSLFPLALPGMLALL-GWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DSA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSTP-LS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPPHRRSESSGSL- ------------------------------------------------------------ ---------PNTIDVRFR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------HR-DNSAK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGVLFPRKSAEVC-KQESPFSRVPGRGQPGSPAAPPEK HGS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGEKMLEEGLLSQEH------------------- ---------VVELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPNL-----ASL-EGE EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQ-VGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIESAHTELPKDDA------------------------------------ -----------APAPPITDGK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRDVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE-----------------------------ESLDRN-E-S LDRNEEGL-------------------DRNE-------EGLDRNGEGLDRN--------- ------------------------------------------------------------ EEIEQAAFQIISQVISEASEQV-------------------------------------- --------------------------LATAVGKVAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CVYQ--ASQLQGQEEE-SCVPVH-------------------------- ----------------------------------------------------QQTVLGS- ------------HTGEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------IAEAAAA----------R----- ------------------------------------------------------------ ---------------SDAALPSPGL----------PAEG--------------------- -----------------------SAPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSSPI-KD------------------------------------------------SK-P KISAHHISLAPCLP---------------------------------------------- ---------------------PT-TPGEE-------------------SP--------DR AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSLSTSGL----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDVEADHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSPTEP00000043272 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DSA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDIC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSMP-PS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPPRRRSESSGSL- ------------------------------------------------------------ ---------PNTIDMRLQ----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-HNSTK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGVLFPHKSAEVC-KQESPFSRVPGRGQPGYPAAPPEE HGS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGEKVLEEDLLSQER------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPNL-----ASL-EGE EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQ-VGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIESAYTELPKDDV------------------------------------ -----------APAPPIIDAK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRDVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NEESLDR---NESLDR-------------NEESLDRNEE-S LDRNEESL-------------------DRNEEGLDRNGEGLDRNGEGLDRN--------- ------------------------------------------------------------ EEIEQAAFQIISQVISEASEQV-------------------------------------- --------------------------LATAVDKVAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CVYQ--ASQLQGQEEE-SCVPVH-------------------------- ----------------------------------------------------QQTVLGS- ------------DTGEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------IAEAAAA----------L----- ------------------------------------------------------------ ---------------LDAALPSPGL----------PAEG--------------------- -----------------------SAPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSSPI-KD------------------------------------------------SK-P KISAHHISLAPCLP---------------------------------------------- ---------------------PT-TPGEE-------------------SP--------DR AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSLSTSGL----------EDSCTETSSSSRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDVEADHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSMFAP00000022427 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DSA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSMP-PS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTMSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPPRRRSESSGSL- ------------------------------------------------------------ ---------PNTIDMRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-DNSAK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETKL--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGVLFPHKSAEVC-KQESPFSRVPGRGQPGYPAAPPEK HGS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGEKVLEEDLLSQEH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPNL-----ASL-EGE EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQ-VGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIKSAHTELPKDDA------------------------------------ -----------APAPPITDAK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRDVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE-----------------------------ESLDRNEE-N LDRNEESL-------------------DRNEEGLDRNEEGLDRNGEGLDRN--------- ------------------------------------------------------------ EEIEQAAFQIISQVISEATEQV-------------------------------------- --------------------------LATAVGKVTG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CVYQ--ASQLQGQEEE-SCVPVH-------------------------- ----------------------------------------------------QQTVLGS- ------------DTGEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAAAA----------P----- ------------------------------------------------------------ ---------------SDAALPSPGL----------PAEG--------------------- -----------------------SAPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSSPI-KD------------------------------------------------SK-P KISAHHISLTPCLP---------------------------------------------- ---------------------PT-TPGEE-------------------SP--------DR AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSLSTSGL----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDVEADHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSMNEP00000000292 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DSA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSMP-PS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTMSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPPRRRSESSGSL- ------------------------------------------------------------ ---------PNTIDMTLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DNSAK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETKL--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGVLFPHKSAEVC-KQESPFSRVPGGGQPGYPAAPPEK HGS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGEKVLEEDLLSQEH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPNL-----ASL-EGE EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQ-VGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIKSAHTELPKDDA------------------------------------ -----------APAPPITDAK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRDVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE-----------------------------ESLDRNEE-N LDRNEESL-------------------DRNEEGLDRNEEGLDRNGEGLDRN--------- ------------------------------------------------------------ EEIEQAAFQIISQVISEATEQV-------------------------------------- --------------------------LATAVGKVTG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CVYQ--ASQLQGQEEE-SCVPVH-------------------------- ----------------------------------------------------QQTVLGS- ------------DTGEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAAAA----------P----- ------------------------------------------------------------ ---------------SDAALPSPGL----------PAEG--------------------- -----------------------SAPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSSPI-KD------------------------------------------------SK-P KISAHHISLTPCLP---------------------------------------------- ---------------------PT-TPGEE-------------------SP--------DR AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSLSTSGL----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDVEADHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSCATP00000042803 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DSA IKES-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSVP-PS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPPRRRSESSGSL- ------------------------------------------------------------ ---------PNTIDMRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DNSAK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGVLFPHKSAEVC-KQESPFSRVPGRGQPGYPAAPPEK HGS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGEKVLEEDLLSQEH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPNL-----ASL-EGE EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQ-VGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIKSAHTELPKDDV------------------------------------ -----------APAPPITDAK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRDVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE-----------------------------ESLDRNEE-S LDRNEESL-------------------DRNEEGLDRNEEGLDRNGEGLDRN--------- ------------------------------------------------------------ EEIEQAAFQIISQVISEATEQV-------------------------------------- --------------------------LATAVGKVTG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CVYQ--ASQLQGQEEE-SCVPVH-------------------------- ----------------------------------------------------QQTVLGS- ------------DTGEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAAAA----------P----- ------------------------------------------------------------ ---------------SDAALPSPGL----------PAEG--------------------- -----------------------SAPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSSPI-KD------------------------------------------------SK-P KISAHHISLTPCLP---------------------------------------------- ---------------------PT-TPGEE-------------------SP--------DR AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSLSTSGL----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDVEADHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSPANP00000020342 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DSA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSMP-PS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRTHPPRRRSESSGSL- ------------------------------------------------------------ ---------PNTIDMRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DNSAK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGVLFPHKSAEVC-KQESPFSRVPGRGQPGYPAAPPEK HGS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGEKVLEEDLLSQEH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPNL-----ASL-EGE EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQ-VGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIKSAHTELPKDDA------------------------------------ -----------APAPPITDAK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRDVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------IE-----------------------------ESLDRNEE-N LDRNEESL-------------------DRNEEGLDRNEEGLDRNGEGLDRN--------- ------------------------------------------------------------ EEIEQAAFQIISQVISEATEQV-------------------------------------- --------------------------LATAVGKVTG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CVYQ--ASQLQGQEEE-SCVPVH-------------------------- ----------------------------------------------------QQTVLGS- ------------DTGEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAAAA----------P----- ------------------------------------------------------------ ---------------SDAALPSPGL----------PAEG--------------------- -----------------------SAPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSSPI-KD------------------------------------------------SK-P KISAHHISLTPCLP---------------------------------------------- ---------------------PT-TPGEE-------------------SP--------DQ AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSLSTSGL----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDVEADHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSTGEP00000029438 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRLLFPLALPGMLALL-GWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DSA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSMP-PS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPPRRRSESSGSL- ------------------------------------------------------------ ---------PNTIDMRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DNSAK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGVLFPHKSAEVC-KQESPFSRVPGRGQPGYPAAPPEK HGS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGEKVLEEDLLSQEH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPNL-----ASL-EGE EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQ-VGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIKSAHTELPKDDA------------------------------------ -----------APAPPITDAK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRDVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------IE-----------------------------ESLDRNEE-N LDRNEESL-------------------DRNEEGLDRNEEGLDRNGEGLDRN--------- ------------------------------------------------------------ -EIEQAAFQIISQVISEATEQV-------------------------------------- --------------------------LATAVGKVTG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CVYQ--ASQLQGQEEE-SCVPVH-------------------------- ----------------------------------------------------RQTVLGS- ------------DTGEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAAAA----------P----- ------------------------------------------------------------ ---------------SDAALPSPGL----------PAEG--------------------- -----------------------SAPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSSPI-KD------------------------------------------------SK-P KISAHHISLTPCLP---------------------------------------------- ---------------------PT-APGEE-------------------SP--------DQ AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSLSTSGL----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDVEADHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSMLEP00000024234 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DSA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSMP-PS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPPRRRSESSGSL- ------------------------------------------------------------ ---------PNTIDMRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DNSAK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGVLFPHKSAEVC-KQESPFSRVPGRGQPGYPAAPPEK HGS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGEKVLEEDLLSQEH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPNL-----ASL-EGE EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQ-VGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIKSAHTELPKDDA------------------------------------ -----------APAPPITDAK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRDVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE-----------------------------ESLDRNEE-S ---------------------------------LDRNEEGLDRNGEGLDRN--------- ------------------------------------------------------------ EEIEQAAFQIISQVISEATEQV-------------------------------------- --------------------------LATAVGKVTG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CVYQ--ASQLQGQEEE-SCVPVH-------------------------- ----------------------------------------------------QHTVLGS- ------------DTGEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAAAA----------P----- ------------------------------------------------------------ ---------------SDAALPLPGL----------PAEG--------------------- -----------------------SAPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSSPI-KD------------------------------------------------SK-P KISAHHISLTPCLP---------------------------------------------- ---------------------PT-TPGEE-------------------SP--------DR AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSLSTSGL----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDVEADHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSCSAP00000001939 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DSA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSMP-PS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLWAHPPRQRSESSGSL- ------------------------------------------------------------ ---------PNTIDMRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GR-DNSAK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGILFPHNSAEVC-KQESPFSRVPGRGQPGYPAAPPEK HGS------------GERA----------------------------------------- -------------RETGGAKGTGDAVLGEKVLEEDLLSQEH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPNL-----ASL-EGE EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQ-VGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIKSAYTELPKDDA------------------------------------ -----------APAPPITDAK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRDVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE-----------------------------ESLDRNEE-S LDRNEES--------------------------LGRNEESLDRNGEGLDRN--------- ------------------------------------------------------------ EEIEQAAFQIISQVISEATEQV-------------------------------------- --------------------------LATTVGKVAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CVYQ--ASQLQGQEEE-SCVPVH-------------------------- ----------------------------------------------------QQTVLGS- ------------DTGEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAAAA----------P----- ------------------------------------------------------------ ---------------SDAALPSPGL----------PAEG--------------------- -----------------------SAPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSSPI-KD------------------------------------------------SK-P KISAHHISLTPCLP---------------------------------------------- ---------------------PT-TPGEE-------------------SP--------DR AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSLSTSGL----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDVEADHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSCANP00000003168 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DSA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPVEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSMP-PS VTEL--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPPRRRSESSGSL- ------------------------------------------------------------ ---------PNTVDMRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-DNSAK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LACPLSSPKGVLFPHKSAEVY-KQESPFSRVPGRGQPGYPAAPPEE HGS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGEKVLEEDLLSQER------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPNL-----ASL-EGE EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQ-VGPAQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIESAYTELPRDDA------------------------------------ -----------APAPPITDAK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRDVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE-----------------------------ESLDRN---- -------------------------------ESLDRNEEGLDRNGEGLDRN--------- ------------------------------------------------------------ EEIEQAAFQIISQVISEASEQV-------------------------------------- --------------------------LATAVGKVAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CVYQ--ASQLQGQEEE-SCVPVH-------------------------- ----------------------------------------------------QQTALGS- ------------DTGEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------IAEAAAA----------P----- ------------------------------------------------------------ ---------------SDAALPSPGL----------PAEG--------------------- -----------------------SAPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSSPI-KD------------------------------------------------SK-P KISAHHISLAPCLP---------------------------------------------- ---------------------PT-TPGEE-------------------SP--------DR AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSLSTSGL----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDVEADHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSNLEP00000032899 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKGHVSSHDG-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DPA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPVEDIC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSTP-PS VTEL--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRTHPPCRRSESSGVL- ------------------------------------------------------------ ---------PNTTDMRSR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DDSTK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------S- --------------LECPLSSPKGVLFPHKSAEVC-KQDSLFSRVPRRVQPGYPAVPTEK RSS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLREKVLEEALLSQEH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPSL-----ASL-DGE EDKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQVVGPVQEEEYVAEKLPGG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIESAHTELAKDDA------------------------------------ -----------APAPPVTDAK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRGVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE------------------------------------E-S LDRNEEGL-------------------DRNEESLDRNEESLDRNVESLDRN--------- ------------------------------------------------------------ EEIEQAAFQIISQVISEATEQV-------------------------------------- --------------------------LATTVGKVAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVYQ--ASQLQGQKEE-SCVPVH-------------------------- ----------------------------------------------------QKTVLGP- ------------DTAEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAAAA----------P----- ------------------------------------------------------------ ---------------PDAALPLPGL----------PAEG--------------------- -----------------------SPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSSPT-KD------------------------------------------------GK-P KISAHHISLAPCLA---------------------------------------------- ---------------------PT-TPSEE-------------------SP--------DR AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSVSTSGL----------EESCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDAEADHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSPPYP00000009263 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-SWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DPA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSTP-PS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRTHPPCRRSESSGIL- ------------------------------------------------------------ ---------PNTTDMRSR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DNSTK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGVLFPNKSAEVC-KQDSPFSRVPGRVQPGYPAVPAEK RSS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGRTVVEEALLSQEH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKGPSL-----ASL-EGE EDKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQVVGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIESAHTELAKDDA------------------------------------ -----------APAPPVTDTK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRGVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE------------------------------------ERS LDRNEEGL-------------------DRNEEGLDRNE-------EGLDRN--------- ------------------------------------------------------------ EEIEQAAFQIISQVISEATEQV-------------------------------------- --------------------------LATTVGKVAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVYQ--ASQLQGQKEE-SCVPVH-------------------------- ----------------------------------------------------QKTVLGP- ------------DTAEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------PVEAAAA----------P----- ------------------------------------------------------------ ---------------PDAALPLPGL----------PAEG--------------------- -----------------------SPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSSPT-KD------------------------------------------------SK-P KISAHHISLAPCLA---------------------------------------------- ---------------------PT-TPSEE-------------------LP--------DR AGIL------------------------------VEDAT---CATCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSFSTSGL----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDAEADHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSPPAP00000015965 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKGHVSSHDEQQ---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DPA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PK ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSTP-PS VTGP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLQTHPPCRRSESSGIF- ------------------------------------------------------------ ---------PNTTDMRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DDSTK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGVLFSSKSAEVC-KQDSPFSRVPRKVQPGYPAVPAEK HSS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGEKVLEEALLSREH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKGPSL-----ASL-EGE EDKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQVVGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIESAHTELAKDDV------------------------------------ -----------APAPPVADAK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRGVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE------------------------------------E-S LDRNEEGL-------------------DRNEEGLDRNEESLDRNEEGLDRN--------- ------------------------------------------------------------ EEIERAAFQIISQVISEATEQV-------------------------------------- --------------------------LATTVGKVAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVCQ--ASQLQGQKEE-SCVPVH-------------------------- ----------------------------------------------------QKTVLSP- ------------DTAEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAAAA----------P----- ------------------------------------------------------------ ---------------PDAGLPLPGL----------PAEG--------------------- -----------------------SLPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KSL LSSPT-KD------------------------------------------------SK-P NISAHHISLASCLA---------------------------------------------- ---------------------PT-TPSEE-------------------SP--------DR AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSFSTSGL----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDAEGDHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYTSL------- ------------------------------------------------------------ - >ENSPTRP00000016025 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKGHVSSHDEQQ---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DPA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PK ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSTP-PS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLQTHPPCRRSESSGIF- ------------------------------------------------------------ ---------PNTTDMRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DDSTK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGVLFSSKSAEVC-KQDSPFSRVPRKVQPGYPAVPAEK HSS------------GERA----------------------------------------- -------------RETVGAEGTGDAVLGEKVLEEALLSREH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKGPSL-----ASL-EGE EDKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQVVGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIESAHTELAKDDV------------------------------------ -----------APAPPVADAK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRGVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE------------------------------------E-S LDRNEEGL-------------------DRNEEGLDRNEESLDRNEEGLDRN--------- ------------------------------------------------------------ EEIERAAFQIISQVISEATEQV-------------------------------------- --------------------------LATTVGKVAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVCQ--ASQLQGQKEE-SCVPVH-------------------------- ----------------------------------------------------QKTVLSP- ------------DTAEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAAAA----------P----- ------------------------------------------------------------ ---------------PDAGLPLPGL----------PAEG--------------------- -----------------------SLPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KSL LSSPT-KD------------------------------------------------SK-P NISAHHISLASCLA---------------------------------------------- ---------------------PT-TPSEE-------------------SP--------DR AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSFSTSGL----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDAEGDHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYTSL------- ------------------------------------------------------------ - >ENSP00000478212 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKGHVSSHDEQQ---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DPA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPVEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PK ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSTP-PS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLQTHPPCRRSESSGIL- ------------------------------------------------------------ ---------PNTTDMRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DDSTK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGVLFSSKSAEVC-KQDSPFSRVPRKVQPGYPVVPAEK RSS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGEKVLEEALLSREH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKGPSL-----ASL-EGE EDKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQVVGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIESAHTELAKDDA------------------------------------ -----------APAPPVADAK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRGVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE------------------------------------E-S LDRNEEGL-------------------DRNEEGLDRNEESLDRNEEGLDRN--------- ------------------------------------------------------------ EEIKRAAFQIISQVISEATEQV-------------------------------------- --------------------------LATTVGKVAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVCQ--ASQLQGQKEE-SCVPVH-------------------------- ----------------------------------------------------QKTVLGP- ------------DTAEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAAVA----------P----- ------------------------------------------------------------ ---------------PDAGLPLPGL----------PAEG--------------------- -----------------------SPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KSL LSSPT-KD------------------------------------------------SK-P NISAHHISLASCLA---------------------------------------------- ---------------------LT-TPSEE-------------------LP--------DR AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSFSTSGL----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDAEADHSG----GSDRNSMDSVDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYTSL------- ------------------------------------------------------------ - >ENSGGOP00000023166 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKGHVSSHDEQQ---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DPA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------SK ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSTP-PS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRTHPPCRRSQSSGIL- ------------------------------------------------------------ ---------PNTTDMRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DDSTK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGVLFSSKSAEVC-KQDSPFSRVPGKVQPGYPAVPAEK RSS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGEKVLEEVLLSREH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKGPSL-----ASL-EGE EDKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQVVGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIESAHTELAKDDA------------------------------------ -----------APAPPVADAK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRGVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE------------------------------------E-S LDRNEEGL-------------------DGNEEGLDRNEESLDRNEESLDRN--------- ------------------------------------------------------------ EEIERAAFQIISQVISEATEQV-------------------------------------- --------------------------LATTVGKVAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVCQ--ASQLQGQKEE-SCVPVH-------------------------- ----------------------------------------------------QKTVLGP- ------------DTAEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAAAA----------P----- ------------------------------------------------------------ ---------------PDAGLPLPGL----------PAEG--------------------- -----------------------SPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KSL LSSPT-KD------------------------------------------------SK-P NISAHHISLASCLA---------------------------------------------- ---------------------PT-TPSEE-------------------SP--------DR AGIL------------------------------VEDAT---CVTCMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSFSTSGL----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TVDAEADHSG----GSDRNSMDSMDSC-CSLKKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDQFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYTSL------- ------------------------------------------------------------ - >ENSCANP00000036945 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFHSLFSLALLGMLALL-VWWWFLSRKKGHVSRHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DSA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSMP-PS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTVSKMPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPPRQRSESSGSL- ------------------------------------------------------------ ---------PNAIDMRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-DNSAK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGVLFPHKSAEVC-KQESPFSRVPGRGQPGYPAAPPEE HGS------------GERA----------------------------------------- -------------RETGGAEGTGHAVLGEKLLEEGLLSQEH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPNL-----ASL-EGE EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SSQ-VGPVQEEEYVAEKLPSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FIESAHTELPKDDA------------------------------------ -----------APAPPITDAK----------------------------A---------- ------------------------------------------------------------ ------------------------------QDRDVEGQLG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE-----------------------------ESLDRN---- -----QSL-------------------DRNEESLDRNEEGLDRNGEGLDRN--------- ------------------------------------------------------------ GEIEQAAFQIIFQVISEASEQV-------------------------------------- --------------------------LATVVGKVAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CVYQ--ASQLQGQEEE-SCVPVH-------------------------- ----------------------------------------------------QQTVLGS- ------------DTGES--A---------------------------------------- ------------------------------------------------------------ -------------------------------------IAEAAAA----------P----- ------------------------------------------------------------ ---------------SDAALPSPGL----------PAEG--------------------- -----------------------SAPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NGP LSSPI-KD------------------------------------------------SK-P KISAHHISLAPRLP---------------------------------------------- ---------------------PT-TPDEE-------------------SP--------DR AGIL------------------------------VEDAT---CVTGMSDSSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSLRTSGL----------EDSCTETSSSPRGK-AVTPPLPE-STVPFSNGALKG ELSDLGAEDGR------------------------------------------------- --------------TMDVDADRSG----GSDRSSMDSVDSC-CSLKKTESFQ-NAQADSN PQKIDLIIWEIVVP-KHLVGQLIGKHGWYVSFLRQASGAKIYISTLPYIQSIQICHIEGS QNHVDKALYLIGKKFKELNLTNIYAPPLPS-LA---LPSLPVTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPAFHALHSLDQQMSLCYSQPGIPTLPTPVEI AVICAAPGADG-AWWRAQVIASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DNDQFSPEADAAMREMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASVLP----- -----------------------------------------------QFPMLFPESLFLQ C >ENSCJAP00000025727 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLVLL-GWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DPA IREP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVH------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VASTT-PS VTQP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTLNKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRTHPPCQKSESSGSL- ------------------------------------------------------------ ---------PNTADMRLR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DDSAK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSAKGLLFPHEATEAC-KQESPFSRVPGRGQPGYAAAPAEK HGS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGETVLEEGLLSREH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPSL-----APL-AGE EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVVGLMCKEEYVVEKLPSS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------LIKLAHTGLAKGDE------------------------------------ -----------VPAPPVTDSK----------------------------V---------- ------------------------------------------------------------ ------------------------------QDRDVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE--------------------------------------- ---------------------------------------------DSLDRN--------- ------------------------------------------------------------ EEIEQAAFQIISQVISEATEQV-------------------------------------- --------------------------LTTAVSEVSG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------HVHQASASQLQGQKEE-SCVPTH-------------------------- ----------------------------------------------------QKTVLGP- ------------NTAEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAAAA----------L----- ------------------------------------------------------------ ---------------SDAALPSPGL----------RAEG--------------------- -----------------------SPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSSPT-KD------------------------------------------------SK-P KNSAHHISLAPCPP---------------------------------------------- ---------------------PT-TPGGE-------------------SL--------DG VSIL------------------------------VEDAT---CVSCMSDSSQD--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSLSTSGI----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKE ELSDLGAEDGW------------------------------------------------- --------------TVDAEADHSG----GSDRNSMDSVDSC-CGLKKTESVQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALTLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSSBOP00000004809 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLVLL-GWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DPA IREP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVH------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PK ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VASTP-PS VTQP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEPSALNKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRTHPPCRKSESSGSL- ------------------------------------------------------------ ---------PNTTDMRSR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DDSAK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSAKGLLFPHEATKVC-KQESPFSRVPGRGQSGHPATPAQK HGS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGENVLEEGLLSQEH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKASSL-----APS-AGE EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVVELVQKEAYVAEKLPSS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------LVELAHTELVKGDE------------------------------------ -----------VPAPPVRDGK----------------------------V---------- ------------------------------------------------------------ ------------------------------QERDVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE--------------------------------------- ---------------------------------------------ESLDRN--------- ------------------------------------------------------------ EKIEQAAFQIISQVISEATEQV-------------------------------------- --------------------------LATTVSEVAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------HVHQASASQLQGQKEE-SCVLIH-------------------------- ----------------------------------------------------QKTVLGP- ------------DTAEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------AAEAAAA----------P----- ------------------------------------------------------------ ---------------LDAALLSPDL----------PAED--------------------- -----------------------SPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSS LSSPT-KD------------------------------------------------SK-P KNSAHHISLAPCPP---------------------------------------------- ---------------------PT-TPGGE-------------------SP--------DG VSIL------------------------------VEDAT---CVTCMSDSSQD--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSLSTSGI----------EDSCTETSSSPRDK-AITPPLPE-STVPFSNGVLKE ELSDLGAEDGW------------------------------------------------- --------------TVDAEADHSG----GSDRNSMDSVDSC-CGLKKTESVQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALTLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSCCAP00000011572 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAVQFRSLFPLALPGMLVLL-GWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DPA IRKP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDVH------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VASTA-PS VTQL--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEPSTLNKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRTHPPCRKSESSGSL- ------------------------------------------------------------ ---------PNTTDMRSR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DDSAK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSAKGLLFPHEATEVC-KQESPFSRVPGRGRPGHPTAPAEK HGS------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGENVLEEGLLSREH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPSL-----APL-AGE EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVVELVQKEEYVVEKLPSS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------LIELAHTQLVKGDE------------------------------------ -----------APAPPVTDGK----------------------------V---------- ------------------------------------------------------------ ------------------------------QDRDVEGELGN------------------- ------------------------EESLD------------------------------- ------------------------------------------------------------ ------------------RNE--------------------------------------- ---------------------------------------------ESLDRN--------- ------------------------------------------------------------ EKIEQAAFQIISQVISEATEQV-------------------------------------- --------------------------LATAVSEVAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------HVHQALASQLQGQKEE-SCVLIH-------------------------- ----------------------------------------------------QKTVLGP- ------------DTAEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAAAA----------P----- ------------------------------------------------------------ ---------------SDAALLSPGL----------PAEG--------------------- -----------------------SPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSL LSSPT-KD------------------------------------------------SK-P KNSAHHISLAPCPP---------------------------------------------- ---------------------LT-TPGGE-------------------SP--------DG VSIL------------------------------VEDAT---CVTCMSDSSQD--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LVA SPGHCSDSLSTSGI----------EDSCTETSSSPRDK-AVTPPLPE-STVPFSNGVLKE ELSDLGAEDGW------------------------------------------------- --------------TVDAEADHSG----GSDRNSMDSVDSC-CGLKKTESVQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALTLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSANAP00000028878 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLMLL-GWWWFFSRKKGHVSSHDE-Q---------VEAG AVQL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DPA IREP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEDAH------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSTA-PS VTQP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEPSTLNKLPAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLQTHPPCRKSESSGSL- ------------------------------------------------------------ ---------PNTTDMRSQ----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LR-DESAK -----------------------------------------LELALTGG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LGCPLSSAKGLLFPHEATEVC-KQESPISRVRGRAQPGHPAAPAET HGS------------GERA----------------------------------------- -------------RETGGAEGTSDAVLGENALEEGLLSREH------------------- ---------VLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPSL-----APL-AGK EEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVV-LVQKEEYVVEKLPSS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------PIELAHTELAKGDE------------------------------------ -----------APAPPVTDGK----------------------------V---------- ------------------------------------------------------------ ------------------------------QDRGVEGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE--------------------------------------- ---------------------------------------------DSLDRN--------- ------------------------------------------------------------ EKIEQAAFHIISQVISEATEQV-------------------------------------- --------------------------LATAVSEVAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------HVHQASASQLQGQKEE-SFVPIH-------------------------- ----------------------------------------------------QKTVLGP- ------------DTAEP--A---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAAAA----------L----- ------------------------------------------------------------ ---------------SDAAFLSSGL----------PAEG--------------------- -----------------------SPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSNPT-KD------------------------------------------------SK-P KNSAHHISLAPCPP---------------------------------------------- ---------------------LT-TPGGE-------------------SP--------DG VSIL------------------------------VEDAT---CVTCMSDSSQD--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------FVT SPGHCSDSLSTSGI----------EDSCTETSSSPRDK-AITPPLPE-NTVPFSNGVLKE ELSDLGAEDGW------------------------------------------------- --------------TMDAEADHSG----GSDRNSMDSMDSC-CGLKKTESVQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGS QHHVDKALTLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI MVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASLR------ ------------------------------------------------------------ - >ENSOGAP00000009857 Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ASR----------------------- ------MVLQFRSLFPLALPGMLALL-GWWWFFSRKKD---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ DD--------GDISRQ-----------------HEQVEAGAVELRTDSAIKESL------ ----------------------PGEGVF-------------------------------- ------------------------------------------------------------ --------------------------------------------------STVVSTP-AS VTEP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEPSTASKPPVE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRTHPARRRSESSSSL- ------------------------------------------------------------ ---------PNSIDTRSR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RK-DDSVK -----------------------------------------VELAPAGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------PECPLLSPKGVPFPHEAAEVC-KQESTFVRTPGRGWSGQFVGPTEK HGP------------GERA----------------------------------------- -------------RETRGAEGTGDAVLGENVLEEVLLSQEH------------------- ---------VSELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPCL-----ATV-GGG GEKGRSG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SPQLV-----------------QPVQQREE CVV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----EKLLSSF-ESAHTELAKDAE------------------------------------ -----------MPAPHVRGGK----------------------------A---------- ------------------------------------------------------------ ------------------------------WDRDLAGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------ESLDRN--------- ------------------------------------------------------------ EKIEQAAFQIISQVILEATEEV-------------------------------------- --------------------------LATTVGKIAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RMHQASADQLQGQKEE-SYAPGG-------------------------- ----------------------------------------------------PKTDLGR- ------------DTMEPALA---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAASS----------P----- ------------------------------------------------------------ ---------------SDAASPSPGL----------LAGD--------------------- -----------------------LPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------NK-P KNSAYPISLAPCPP---------------------------------------------- ---------------------PD-TPLGE-------------------SL--------DG ASILVEDA------------------------------------TCVSDNCQG--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SLGHCSDSLSTSGL----------EDSGTETNSSPRDK-AITPPLPE-STVPFSNGVLKE ELSDLGADDGW------------------------------------------------- --------------TLDAEGDHSG----GSDRNSMDSVDSC-GSLRKTESFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSIQICHIEGS QQHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSMICP00000038093 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALQFRSLFPLALPGMLALL-GWWWFFSRKKDHVSRHSE-Q---------VEAS AVEL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DSA IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPLEDIY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSTA-PS VTQP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEPSTMSKPSAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRIQPARRRSESSGSL- ------------------------------------------------------------ ---------PNATDARPR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RK-DDSGK -----------------------------------------LELAPTGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------DAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLSSPKGIPFPHEAAEVC-KQESMFSRTPGRGWPGQSAAPAEK HGP------------GERA----------------------------------------- -------------RETGGAEGTGDAVLGENVLEEGLLSQES------------------- ---------VSELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPRL-----APL-GGG GKKGRSG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------LPQVV-----------------VPTQQKEE YVV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GKLLSSFIESAHTELAKDDE------------------------------------ -----------TPAPSVRGGK----------------------------A---------- ------------------------------------------------------------ ------------------------------WDRDLAGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------ESLDRN--------- ------------------------------------------------------------ DKIEQAAFQIISQVILEATEEV-------------------------------------- --------------------------LATTVGKIAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RIYQASAGQLQGQKEE-SCVPGS-------------------------- ----------------------------------------------------PKTVLGQ- ------------DAAEPTLA---------------------------------------- ------------------------------------------------------------ -------------------------------------VAEAATS----------P----- ------------------------------------------------------------ ---------------SGAAPPSPGL----------PAED--------------------- -----------------------LPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------NK-P KNSAHPISLASCPL---------------------------------------------- ---------------------PA-APLRE-------------------SL--------DG -----EDA------------------------------------ICMSDNSQG--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SLGHCSDSLSTSGL----------EDSGTETNSSPRDK-AISPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TLDAEADHSG----GSDGNSMDSVDSC-GSLRKTESFQ-NAQAGSS PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVASYEDTNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GTEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYANL------- ------------------------------------------------------------ - >ENSPCOP00000004604 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALQFRSLFPLALPGMLALL-GWWWFFSRKKDHVSRHSR-Q---------AEAS AAEL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SA---------------DSA VKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------PPVEDVC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSAP-PS VTQP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEPSAASKPSAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRIQAARRRSESSGSL- ------------------------------------------------------------ ---------PNATDTRPR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RK-DDSAK -----------------------------------------LDLALTGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------DAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------PECPLSS----PFPHEAAEVC-KQESVFSRTPGRGWPGQSAAPAEK HGP------------GDRA----------------------------------------- -------------RETGGAEGTGDAVLGENVLEEGLLSQER------------------- ---------VSELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKAPRL-----APL-GGG GEKGRSG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------LPQVL-----------------VPTQQKEE YVV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GKLLSSFIESAHTELAKDDE------------------------------------ -----------TPAPSVRGGK----------------------------A---------- ------------------------------------------------------------ ------------------------------WDRDLAGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------NE--------------------------------------- ---------------------------------------------ESLDRS--------- ------------------------------------------------------------ DKIEQAAFQIISQVILEATEEV-------------------------------------- --------------------------LATTVGKIAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RIYQASAAQLQGQKEQ-SCVPGS-------------------------- ----------------------------------------------------PKTVLGQ- ------------NAAEPTLA---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAATS----------P----- ------------------------------------------------------------ ---------------LDAAPPAPAL----------LAED--------------------- -----------------------LPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------NK-P KNSAHPIALAPCPP---------------------------------------------- ---------------------PA-APLRE-------------------SL--------DG -----EDA------------------------------------TCMSDNSQG--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SSGHCSDSLSTSGL----------EDSGTETNSSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TLDAEADHSG----GSDGNSMDSVDSC-GSLRKTEGFQ-NAQAGSS PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GTEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYGSL------- ------------------------------------------------------------ - >ENSOPRP00000015055 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQLRSLFPLALPGMLALL-GWWWFFSRKKEQVSSHDR-Q---------AETS AVEL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DPA IQDP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMGEACG------------------ --------RMST---PLSVTL-------------------------PAEKESR------- ------------------------------------------------------------ ---------------------------------------------------------KP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------AVE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALPRMHPTRHRSESSGSL- ------------------------------------------------------------ ---------LNATDARSP----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-DDSAK -----------------------------------------VEFTLISD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKL--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------PACPLPSTKDVQFLHEAAEVC-KQESVTSRVPRRSWPDQSVPSAEK HSP------------EEKA----------------------------------------- -------------KEMGGTEGTGDAVLGENVLEEGLLPQEQ------------------- ---------RSELES--------------------------------------------- ------------------------------------------------------------ ------------------------------------------CKAPSL-----ASL-GGD GEKGQSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVA---------------VSVPV-QKEE CTV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GKLLSSFVESAPIELAKDDE------------------------------------ -----------LPATQVRGGQ----------------------------V---------- ------------------------------------------------------------ ------------------------------QDKELIGELS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------GALDTN--------- ------------------------------------------------------------ EKIEQAAFQIISQVILEATEEV-------------------------------------- --------------------------LATTVGKIAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RIYQASATQLPGQKEE-DCAPIS-------------------------- ----------------------------------------------------QRTVLGQ- ------------EAAEPTLA---------------------------------------- ------------------------------------------------------------ -------------------------------------TAKAAVE----------P----- ------------------------------------------------------------ ---------------LDTAFPLPGL----------PMED--------------------- -----------------------QSSP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -SL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPI-KD------------------------------------------------GK-P KISAHHISLTPCPV---------------------------------------------- ---------------------PA------------------------------------- -------ASL--------------GEAQDDSCDSVEDTT---CDTCTSDDGQG--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SMT SLGQCSDSVSTSGL----------GDSCTETTSTPRDK-SITPPLPE-NTVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDAEADHSG----GSDGNSMDSADSC-CSLQKTNGSH-NIQAGSS PNKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGLDG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDELRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNAALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVSGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYANL------- ------------------------------------------------------------ - >ENSOCUP00000015087 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQLRSLFPLALPGMLALL-GWWWFFSRKKEQVSSHDR-Q---------AEAG AVEL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------DPA IQEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PR ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSTS-PS VTLP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KE---LSK-PVE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRTHPTRRRSESSGSL- ------------------------------------------------------------ ---------PNATDARSQ----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CK-GDGAK -----------------------------------------VELALMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------PECPLPSPKGVQFPHEAAEVC-KRESVLSKAPGKGWPDQSMASTEK HGP------------GERA----------------------------------------- -------------RETGGTEGTGDAVLGENVLEEGLLSHEH------------------- ---------VSELES--------------------------------------------- ------------------------------------------------------------ ------------------------------------------CKAPGL-----APL-GGG GEKGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------LPQVL-----------------VPL-EKEE CAA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GKLLSSFVESAPMELGKDDE------------------------------------ -----------MPASRVRGGK----------------------------V---------- ------------------------------------------------------------ ------------------------------WDRDLMGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------ETEDKN--------- ------------------------------------------------------------ EKIEQAAFQIISQVILEATEEV-------------------------------------- --------------------------LATTVGKIAD------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RIYQASAAQLQGQKDE-GCAPVS-------------------------- ----------------------------------------------------QKTVLGQ- ------------EAAEPTLA---------------------------------------- ------------------------------------------------------------ -------------------------------------SVEAAAE----------P----- ------------------------------------------------------------ ---------------SDTALPLPGL----------PAED--------------------- -----------------------LPTP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPS-KD------------------------------------------------GK-P KNSAHHISLAPCPA---------------------------------------------- ---------------------LA------------------------------------- -------ASL--------------GGVQDDACILVEDTV---CDTCMSDDGQGCSVA--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVT SSGQCSESVSTSGL----------GDSCTETTSSPRDK-AITPPLKE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDAEADHSG----GSDGNSMDSADSC-CSLQRTDSSH-NAQAGCN PNKVDLIVWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPVTSW--------------- LMLPDGVTVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGLDG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVAGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYANL------- ------------------------------------------------------------ - >ENSEASP00005003940 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKEHISSHDE-Q---------VEAS AVEL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RP---------------DPA LSEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPGEDAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSTP-PS VTQP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTASSPSTE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRVHPACRRSESSGSL- ------------------------------------------------------------ ---------PNATDMRFR----------------------------PG-M---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RK-DDSTR -----------------------------------------VELALTGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------PECPSPSLKGVLFPHEAVEAC-KRESTFSRTAGRGQQG-------- ---GAAPTEKLG--LGEKA----------------------------------------- -------------RETGGAEGTGDAVLGENLPEEGMLSQEH------------------- ---------GSELQN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------GKAPGP-----APL-GGG GEEGKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------PVE EDAAGKLLSSF-KSAHVELAKDDE------------------------------------ -----------TPAPQVRGGR----------------------------A---------- ------------------------------------------------------------ ------------------------------RDGDFTGELR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------ETLDKN--------- ------------------------------------------------------------ EKIEQAAFEIISKVIVEATEEV-------------------------------------- --------------------------LATTMGKIAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVYQASAGQLQGQKEE-SCALVS-------------------------- ----------------------------------------------------QKTSLGQ- ------------DAGEPTLA---------------------------------------- ------------------------------------------------------------ -------------------------------------TAEAATG----------P----- ------------------------------------------------------------ ---------------SDAALPSPGL----------PAED--------------------- -----------------------LSPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------TSP LSSPT-KD------------------------------------------------GK-P KSSAYHISLAPCPPSATL-------------------PRESLDEANVLVEDAGCVTCMSD NCQG----------------GPT------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SSGQCSDSVSTSGL----------EDSCAETNLSPRDK-AITPPLPE-STVPFSNGVLKG ELSDLGTEDGW------------------------------------------------- --------------PVDAEADHSG----GSDGNSMDSVDGC-CGLRKTDGFQ-NAQAGST PNKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGLDG-AWWRAQVVASYEETNEFEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPNGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYSSL------- ------------------------------------------------------------ - >ENSSSCP00000057370 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKDPIGSHDK-Q---------MEAS TVEL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------SPA TEEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPREDTC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VAAMP-PG LTQP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEPTPASKPSVE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHAARRRSESSGSL- ------------------------------------------------------------ ---------LNSTDTRFR----------------------------PG-A---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LK-EDSAR -----------------------------------------VELALAGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKP--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLPSPKGVPFPHEAVEEC-KQESELARTVGQGQQGQSAAPVEP PSP------------GEKA----------------------------------------- -------------REMGGAEGTGDAVLGENRLEEGSLSQEP------------------- ---------G-ELQS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SRAPGL-----APL-GGG GERGRSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPA--------------------------- -AVD--------------------------QE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------AVGKLLSGFVESAHVELATADGPA- ------------------------------------------------------------ -------------APRVRGGR----------------------------ACH-------- ----------GDVPRE-------------------------------------------- ----------------------------LGR----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ---------------------------------------------ETLDRN--------- ------------------------------------------------------------ EKIEQAAFQIISKVILEATEEV-------------------------------------- --------------------------LATTMGRITD------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RIYQASAGQLQKKEEE-SCALAS-------------------------- ----------------------------------------------------QKTARGH- ------------DASEPALA---------------------------------------- ------------------------------------------------------------ -------------------------------------AAEAAVG----------R----- ------------------------------------------------------------ ---------------ADAVLPAADL----------PAGD--------------------- -----------------------LPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------TSP LSSPT-KD------------------------------------------------RK-P KNSAYHMSLAPCPP---------------------------------------------- ---------------------PA-APLGE-------------------AP--------DE AGVL------------------------------GEDAA---CVTCVSNTSQG--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SSGQCS-SISMSGL----------EDSCPETTSSPRDK-ALTPPLPE-SAMPFSNGVLKG ELSDLGTEDGW------------------------------------------------- --------------TVDVEADHSG----GSDGNSMDSVDGC-CGPRKPDGFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVIGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSMLUP00000009868 L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LQASR----------------------- ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKEHVSSHDK-Q---------VEAS AVEL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------GPA IEEL-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------APVENAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------RA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSTP-PS VTQP--------------------------------------A----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------EELATVYKPPTE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRSHPACRRSESSGSL- ------------------------------------------------------------ ---------SNTTDTRVR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-DDSAR -----------------------------------------VEPAQMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKP--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECALPSPKAIRFPHEATEVC-RHEA------GWGQQGQSAAPTEK HGP------------GEKA----------------------------------------- -------------REM-GAEGTGDAVLGESGLEEGVLSLEH------------------- ---------GSALQS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------IKAPSM-----TPL-GGG GEERKSS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------VE GGTAGKLMTSFNELAHVEQAKDDE------------------------------------ -----------TVAPCVQGGR----------------------------A---------- ------------------------------------------------------------ ------------------------------WD----GKLS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------ESLDKN--------- ------------------------------------------------------------ EEIEQAAYQIISKVILDATEEV-------------------------------------- --------------------------LATTVGKMAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------CMYQASAGQLQGQKEE-RCAPIC-------------------------- ----------------------------------------------------QNTALRQ- ------------DALEPTQA---------------------------------------- ------------------------------------------------------------ -------------------------------------TVEAATAL--------GP----- ------------------------------------------------------------ ---------------SNAALPLPGL----------PAED--------------------- ----------------------LLPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------TSP LSSPT-KD------------------------------------------------TK-P KNSVHHIALAPCPP---------------------------------------------- ---------------------PA-APLRE-------------------SL--------DN TSVL------------------------------VEDAG---CVTCMSDNSQG--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SES SSGQCSDSVSTSGL----------EDSCTEINSSPRDN-ATTSPLPQ-STVPFSNGVLKE ELSDLGTEDGW------------------------------------------------- --------------TMDAEADHSG----GSDGNSMDSVDGC-CGLRKTDGFQ-NAQGGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISALPYTQNVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDEHFSPEADAAVSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNY-SPTGIPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSBIXP00000003342 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MTIQFRSLFPLALPGVLALL-GWWWFFSRKKEPLDSHDR-A---------AEAG AVAL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------GPE AQE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VLPV---E DSRPGAASPPPERELCGGGRPSP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E ------------------------------------------------------------ ------------------------------------------------------------ ------------------PA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPACRRSESSGSL- ------------------------------------------------------------ ---------PNPADTRLR----------------------------PG-A---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RK-E---- -----------------------------------------VELTLAGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKA--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLPAPKGLPFPHEAVEVC-KREAVLGRPGGRGRQGQPAAPAEK PAP------------EEKA----------------------------------------- -------------RETGGAEGTGDAVLGENVLEEG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PAAWE--------------------------- ----------------------PAPELELQSSRAAGAGEKDPGRLLEEAVVEAAPEEETL APRGLAGRAWDGAFPQEQGGE--------------------------------------- ---------------------------------------------ETWDRS--------- ------------------------------------------------------------ EKIEQAAFQIISKVILEATEEV-------------------------------------- --------------------------LATTMGRIAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVYQASATQPQGLKEE-SCAPAS-------------------------- ----------------------------------------------------QKTPLGL- ------------EASEPTLT---------------------------------------- ------------------------------------------------------------ -------------------------------------AVEAA------------------ ------------------------------------------------------------ ----------------------PGLRDTALPSTEPPAGD--------------------- -----------------------LPAP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------RK-P KNSAHHISLAPCPL---------------------------------------------- ---------------------PA-APLRE------------------------------- ---------LLDEAGGTGEETTHVP--------------------CVSDGGQA--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------CGA ASGQCSDSASTSGL----------EDCCLETSPSPRGE-AATPPLPE-STVPVSNGVLKG ELSDLGTEDGW------------------------------------------------- --------------TVDAEADHSG----GSDGNSMDSVDSC-CGFRKPDDFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQVCHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVAAYEDTNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSCYSSL------- ------------------------------------------------------------ - >ENSBTAP00000046086 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MTIQFRSLFPLALPGVLALL-GWWWFFSRKKEPLDSHDR-A---------AEAG AVAL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------GPE AQE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VLPV---E DSRPGAASPPPERELCGGGRPSP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E ------------------------------------------------------------ ------------------------------------------------------------ ------------------PA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPACRRSESSGSL- ------------------------------------------------------------ ---------PNPADTRLR----------------------------PG-A---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RK-E---- -----------------------------------------VELTLAGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKA--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLPAPKGLPFPHEAVEVC-KREAVLGRPGGRGRQGQPAAPAEK PAP------------EEKA----------------------------------------- -------------RETGGAEGTGDAVLGENVLEEG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PAAWE--------------------------- ----------------------PAPELELQSSRAAGAGEKDPGRLLEEAVVEAAPEEETL APRGLAGRAWDGAFPQEQGGE--------------------------------------- ---------------------------------------------ETWDRS--------- ------------------------------------------------------------ EKIEQAAFQIISKVILEATEEV-------------------------------------- --------------------------LATTMGRIAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVYQASATQPQGLKEE-SCAPAS-------------------------- ----------------------------------------------------QKTPLGL- ------------EASEPTLT---------------------------------------- ------------------------------------------------------------ -------------------------------------AVEAA------------------ ------------------------------------------------------------ ----------------------PGLRDTALPSTEPPAGD--------------------- -----------------------LPAP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------RK-P KNSAHHISLAPCPL---------------------------------------------- ---------------------PA-APLRE------------------------------- ---------LLDEAGGTGEETTHVP--------------------CVSDGGQA--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------CGA ASGQCSDSASTSGL----------EDCCLETSPSPRGE-AATPPLPE-STVPVSNGVLKG ELSDLGTEDGW------------------------------------------------- --------------TVDAEADHSG----GSDGNSMDSVDSC-CGFRKPDDFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQVCHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVAAYEDTNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSCYSSL------- ------------------------------------------------------------ - >ENSBIXP00005043650 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MTIQFRSLFPLALPGVLALL-GWWWFFSRKKEPLDSHDR-A---------AEAG AVAL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------GPE AQE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VLPV---E DSRPGAASPPPERELCGGGRPSP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPACRRSESSGSL- ------------------------------------------------------------ ---------PNPADTRLR----------------------------PG-A---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RK-E---- -----------------------------------------VELTLAGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKA--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLPAPKGLPFPHEAVEVC-KREAVLSRPGGRGRQGQPAAPAEK PAP------------EEKA----------------------------------------- -------------RETGGAEGTGDAVLGENVLEEE------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PAAWE--------------------------- ----------------------PAPELELQSSRAAGAGEKDPGRLLDEAVVEAAPEEETL APRGLAGRAWDGAFPQEQGGE--------------------------------------- ---------------------------------------------ETWDRS--------- ------------------------------------------------------------ EKIEQAAFQIISKVILEATEEV-------------------------------------- --------------------------LATTMGRIAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVYQASATQPQGLKEE-SCAPAS-------------------------- ----------------------------------------------------QKTPLGL- ------------EASEPTLA---------------------------------------- ------------------------------------------------------------ -------------------------------------AVEAA------------------ ------------------------------------------------------------ ----------------------PGLRDTALPSTEPPAGD--------------------- -----------------------LPAP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------RK-P KNSAHHISLAPCPL---------------------------------------------- ---------------------PA-APLRE------------------------------- ---------LLDEAGGTGEETTHVP--------------------CVSDGCQA--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------CGA ASGQCSDSASTSGL----------EDCCLETSPSPRGE-AATPPLPE-STVPVSNGVLKG ELSDLGTEDGW------------------------------------------------- --------------TVDAEADHSG----GSDGNSMDSVDSC-CGFRKPDDFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQVCHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVAAYEDTNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSCYSSL------- ------------------------------------------------------------ - >ENSBMUP00000033563 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MTIQFRSLFPLALPGVLALL-GWWWFFSRKKEPLDSHDR-A---------AEAG AVAL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------GPE AQE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VLPV---E ASRPGAASPPPERELCGGGRPSP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPACRRSESSGSL- ------------------------------------------------------------ ---------PNPADTRLR----------------------------PG-A---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RK-E---- -----------------------------------------VELTLAGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKA--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLPAPKGLPFPHEAVEVC-KREAVLGRPGGRGRQGQPAAPAEK PAP------------EEKA----------------------------------------- -------------RETGGAEGTGDAVLGENVLEEG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PAAWEHA---------PAVALXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXX-------------------------------------L APRGLAGRAWDGAFPQEQGGE--------------------------------------- ---------------------------------------------ETWDRS--------- ------------------------------------------------------------ EKIEQAAFQIISKVILEATEEV-------------------------------------- --------------------------LATTMGRIAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVYQASATQPQGLKEE-SCAPAS-------------------------- ----------------------------------------------------QKTPLGL- ------------EASEPTLA---------------------------------------- ------------------------------------------------------------ -------------------------------------AVEAA------------------ ------------------------------------------------------------ ----------------------PGLRDTALPSTEPLAGD--------------------- -----------------------LPAP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------RK-P KNSAHHISLAPCPL---------------------------------------------- ---------------------PA-APLRE------------------------------- ---------LLDEAGGTREETTHVP--------------------CVSDGGQA--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------CGA ASGQCSDSASTSGL----------EDCCLETSPSPRGE-AATPPLPE-STVPVSNGVLKG ELSDLGTEDGW------------------------------------------------- --------------TVDAEADHSG----GSDGNSMDSVDSC-CGLRKPDDFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQVCHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVAAYEDTNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSCYSSL------- ------------------------------------------------------------ - >ENSCHIP00000029393 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MTIQFRSLFPLALPGVLALL-GWWWFFSRKKEPLDSHDR-A---------AEAG AVAL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------GPA AQE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------ALTA---E DVRPGVASPPPETELCGSGRPSP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPACRRSESSGSL- ------------------------------------------------------------ ---------PNPADMRLR----------------------------PG-A---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RK-E---- -----------------------------------------VELALAGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKA--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLPAPKGLPFPHEAVEVC-KREAVLGRPGGRGLQGQPAAPVEK PCI------------GEKA----------------------------------------- -------------WETGGAEGTGDAVLGENVLEEG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PAAWE--------------------------- ----------------------PAPELELQSGQAAGAGEKGPGCPLDEAVAEAVP-EETL APRGQAGRAWDGAFPQEQGGE--------------------------------------- ---------------------------------------------ETWDRS--------- ------------------------------------------------------------ EKMEQAAFQIISKVILEATEEV-------------------------------------- --------------------------LATTMGRIAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RVYQASAAQPQEPKEE-SCAPAS-------------------------- ----------------------------------------------------QKTPLGL- ------------EASEPTLAEAE------------------------------------- ------------------------------------------------------------ ---------------APV----------------SLG----------------------- ------------------------------------------------------------ --------------------------DTAVPSAEPLAGD--------------------- -----------------------LPAP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------RK-P KNSAHHISLAPCPP---------------------------------------------- ---------------------PA-APLRE------------------------------- ---------LLDKAGGPGEEATRVP--------------------CVSDGGQA--VPGGD ------SA----------------------------------------------VTSGQ- ------------------------------------------------------------ --------------------------------------------------------H--- -----SDSASNSGL----------EDCCPETAPSPRGE-AATPPLPE-STVPISNGVLKG ELSDLGTEDGW------------------------------------------------- --------------TVDAEADHSG----GSDGNSMDSVDSC-CGLRKPDGFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQVCHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVAAYEDTNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSCYSSL------- ------------------------------------------------------------ - >ENSUPAP00010018095 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIHFRSLFPLALPGMLALL-GWWWFFSRKKEQVSSNDK-K---------VDAG SVVL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------SPD IKKS-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPIQEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------IASTP-CS VTQP--------------------------------------L----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEQSTASKPSVE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ASLRTHPTCRRSESSGCL- ------------------------------------------------------------ ---------PNPTDTRSQ----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------HK-DDTAK -----------------------------------------VELALMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTRS--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLPSPKDVVFPHEAIEVC-KQEVVFSKAPGRGWPSQSVCAAEK HSP------------GEKA----------------------------------------- -------------RETRGAEGTGDAMLGENVLEEGLLSQEC------------------- ---------VSELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKALSL-----APX-GGG GEKG-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------SGGPFSPLREESAVGK LLSSSGKLAHAE------------------------------------------------ --------------LTKDEEMQASEVQDDST----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------WDRDMAAELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KK--------------------------------------- ---------------------------------------------ESLDKN--------- ------------------------------------------------------------ ERIEQAAFQIISQVILEATEEV-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------QAGSGDKMADQLYQASGS-------------------PTVGQA ESSAPASQKT-----------------------VLGQ-----------DTAQAAP----- ------AVVGAAAGAVDSALPLPGP----------PAEN--------------------- -----------------------LPSP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-ED------------------------------------------------SK-P KNSTHHNSLAPCPP---------------------------------------------- ---------------------PA-SPLRE-------------------SV--------DE ASIL------------------------------AEDAT---CATCVS-XSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SAA SSGQCSDSVSTSGL----------EDSCTETNSSPRDK-AITPPLPD-STVPFSNGVLKG ELSDLGTEDGW------------------------------------------------- --------------TADAEADHSG----GSDGNSMDSVDSC-CGLKKTDSFQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYSSL------- ------------------------------------------------------------ - >ENSDORP00000019339 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIHFRTLLPLALPGMLVIL-GWWWFFSRKKEQISSSDK-S---------AEAG AVAR-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------SPV IKKQ-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEESS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVIAP-HS VTQS--------------------------------------L----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEQSPAGMPSGE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AVLRMHVVCRRSETSSSL- ------------------------------------------------------------ ---------PNTIDTRLQ----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LR-DDSAK -----------------------------------------VELSLMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EVKP--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------PEHPFPPPKDVPFPHEAADMG-KQEPELGKASGNGWPSQS------ ----------M------KA----------------------------------------- -------------RETGGAEGTGDAAWGENVHEEGLLSQER------------------- ---------VPELES--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKVLGL-----APL-GGG GEKGSSG----------------------------------------------------- ----------------------------------------------------FHRAGRHS QKEERVVGKTLSNVESAHPELVKEETQVTQIRNGKVCDR--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EVG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------ETVGKN--------- ------------------------------------------------------------ EQIEKAAFQIISQVILEATEEV-------------------------------------- --------------------------LASTEGKMAD------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QVHQAFPIQAQGQEEE-SWASAS-------------------------- ----------------------------------------------------QKTLLGQ- ------------DATKP------------------------------------------- ------------------------------------------------------------ ------AT----------------------------------------------PTAGTA TT---------------------------------------------------------- -------------------------------------ED--------------------- -----------------------LLPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KE------------------------------------------------GK-P KNSAHHISLAACLP---------------------------------------------- ---------------------PA-TPSVE-------------------SV--------EE TSIL------------------------------GRDAT---CVTCMSGNTQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SSGQCSDSLSPSGL----------DGSFTENNSSPRDK-AISPPLPD-STGPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDAEGDHSG----GSDRNSMDSVESG-CGLKKADSLQ-NAQADSN PKKVDLIVWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALSLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYANL------- ------------------------------------------------------------ - >ENSLAFP00000013356 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGVLALL-GWWWFFSRKKERISSHDK-Q---------VEAS AVEL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GT---------------DPP IKD--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LLLT----------------------------- -------------------------------------------------------E---- -----------------------------------------------DTSSSVVPIP-PS VTQP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KELSTMSKPSVE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAQPAPRRSESSGSL- ------------------------------------------------------------ ---------LNTTDTRFR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RR-DDSAK -----------------------------------------LELALTCD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------VECPLASPKGVPFPHEAVEVC-KQEPMFSRMPGRAWPGQSVALTEK HGP------------GEKT----------------------------------------- -------------RETGWAEGTGDAVLGENVLEEGVLSQEH------------------- ---------GSELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKVASL-----APS-GG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------REEKEVTS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQEAGPVQEEEYVAR-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----KLLSSFTESAHTELPNGEE------------------------------------ -----------VSAPGIRGGK----------------------------P---------- ------------------------------------------------------------ ------------------------------QDGDLAGEVG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------EMVARN--------- ------------------------------------------------------------ EELEQAALQIISKVILDASEEVRA------------------------------------ --------AAVDKITTGQVCQASDNEL--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------QGPEEE-SCAPVS-------------------------- ----------------------------------------------------QEPVLGQ- ------------GAVEPTPA---------------------------------------- ------------------------------------------------------------ -----TAT--TTG-----------------------------------------P----- ------------------------------------------------------------ -------LV----------------------------ED--------------------- -----------------------PSPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NSP LSSPT-KD------------------------------------------------SKPP RNSAHHISLASCPS---------------------------------------------- ---------------------RA-TSLGE-------------------SL--------DE ASIL------------------------------VEDAS---CVTCTLDNSQC--DP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVG SLGRCSDSASMSGL----------EDSRTDTNSSPRDK-DITPPLPE-STVPFSNGVLKE ELSDLGAEDGW------------------------------------------------- --------------SMDAETDHSG----GSDGNSMDSVDSC-CSLRKTDGFQ-SAQAGSD PKKVNLIIWEIEVPKKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQDIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPNGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI AVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDGLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDEHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRWLVERGLA-QWVDSCYTNL------- ------------------------------------------------------------ - >ENSDNOP00000022500 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------FCQASG----------------------- ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKEHVSSHSK-Q---------VEAS AVGL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------ST---------------DPA IEDP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPTEDAG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG --------------------------------------AGSASL---------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S VTQL--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEPFTVSKPCAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRAHPAPRRSESSGSL- ------------------------------------------------------------ ---------PNTTDTRFR----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RK-DDSAK -----------------------------------------LEIALTCD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EVKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LECPLPSTKGVPFPHEAVEACSKRESTLGRAPGRGWPALSAAPTEK RGP------------GEKA----------------------------------------- -------------RETGGAEGTGDAVLGESLPEEGVMSWEH------------------- ---------GSELER--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SKVPSL-----APL-GGG ------------------------------------------------------------ ------------------------EENEKTSLAQVVGPAQKEGYGIRK------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------LSSFLEPAHTELVRDDE------------------------------------ ---------------------------------------------------MLEA----- ---------QA------------------------------------------------- --------------------------------RDLVGERG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AD-------------------------- ---------------------------------------------ESLERN--------- ------------------------------------------------------------ EKIEQAAIQIISKVLLEATEEVRATVAEKSSGHKPQASADRQPGHKEEGCALDRQTPVTE QGTTAPALA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------TAEAATAEAAMGALGAVP----- ----PSSD---------------------------------------------------- -----------------------------------PAEG--------------------- -----------------------LSLP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------DSP MSSPT-KD------------------------------------------------TT-P KHSAHPISLVTCPL---VTPLGMPLDGAGVLAEGAGGP---------------------- ---------------------P-------------------------------------- ---------------------------------------------CMSDSSQG--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVV SSGPCSDSASTSGL----------EDSCPETNSSPRDK-ASTPPLPE-STVPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDAEADHSG----GSDGNSMDSMDSC-CGLRKTEGFQ-SVQAGSD AKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALKLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPNGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI AVICAAPGADG-AWWRAQVVASYEETGEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPAGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSCPOP00000011998 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAVQFRSLFPLALPGMLALL-GWWWFFSRKKQQVSSNKE-Q---------AESG AVAL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SA---------------GPT TKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPTEEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ST ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSVP-LS VTQL--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R----------------------NKESAPSKPSTE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------APLWMHLPHHRSESSGSL- ------------------------------------------------------------ ---------QNTTDVRSQ----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RK-DNTTK -----------------------------------------VELAVMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KAKP--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LGCPLTFPKDLLFSQEAAEVC-KQEPTLSGMP----------TTEK RGA------------GEKAR---------------------------------------- ------------EREMGGTEGNGDAVLGETVLAKGLLPQERALDPENGKAFGLAPSGGKI AKGSGSL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------PLVVGPVRALPK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------EE------------------------------------ ---------------------YPLGKLPGVLVQSAKEEATQTPWVTSGNA---------- ------------------------------------------------------------ ------------------------------RDKDPVGELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------EALDEN--------- ------------------------------------------------------------ EKLEQAAFQIISQVILEATEEV-------------------------------------- --------------------------LATT------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------DQAAANQPQGRKEEENCAPVS-------------------------- ----------------------------------------------------QETLMGR- ------------DIIEPTLA---------------------------------------- ------------------------------------------------------------ -------------------------------------TAGAAAS----------S----- ------------------------------------------------------------ ---------------QDTALPSPGP----------LAAD--------------------- -----------------------LPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------RK-P KNSAHPISLAPCPA---------------------------------------------- ---------------------PD-TPLRE-------------------SL--------DQ ASSL------------------------------AGDAT---CVTCMLDKSQS--VS--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------PVT TSGQCSDSVSMSGL----------GDSCTETNSSPKDN-NRTPPLPA-STQPFSNGVLKG ELSDVGTEDGW------------------------------------------------- --------------SVDAEADHSG----GSDANSMDS-ENC-WERRKTDDLQ-NAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVKI MVICAAPGVDG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYLSL------- ------------------------------------------------------------ - >ENSCLAP00000022254 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAVQFRSLFPLALPGMLALL-GWWWFFSRKKQQVSSNEE-Q---------AESS AVAL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GA---------------STA TKEA-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPKEEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSMP-PS VTQP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------G----------------------QEESAPSKPSVE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRMHLPHRRSESSGSL- ------------------------------------------------------------ ---------PSTTDMRSQ----------------------------LG-M---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------HK-DNSTK -----------------------------------------VELAVMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LGCPLAFPKDVLFPHEAVEVC-KQEPALGRVP----------ATEK RGP------------GEKAR---------------------------------------- ------------EREMGGAEGTGDAVRGETLLEEGLLPQGRILGPENGKAVSLASSGGRE EKGSGGL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------PLVVGPVGALPK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------EEH----------TGGKLLRSVM--------------E SAATELVEEEKTRRPQATGGK----------------------------A---------- ------------------------------------------------------------ ------------------------------RDKDPVGERG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------EAVDEN--------- ------------------------------------------------------------ QKLEQAAFQIISQVILGATEEV-------------------------------------- --------------------------LATA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SQAAASQPHGQEEEENSAPVS-------------------------- ----------------------------------------------------QETVLGR- ------------DTVEPPLA---------------------------------------- ------------------------------------------------------------ -------------------------------------LGGTAAS----------P----- ------------------------------------------------------------ ---------------LDTALPSPGL----------PAED--------------------- -----------------------LPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------RK-P KNSAYPISLAPCPP---------------------------------------------- ---------------------PD-TPVRE-------------------SL--------DK ASSP------------------------------VEEAT---CVPCMSDKSQS--VS--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SSGQCSDSVSMSGL----------EDSCPETNSSLRDK-AMTPPLPD-STEPFSNGVLKG ELSDVGTEDGW------------------------------------------------- --------------SVDAEADHSGEALTGSDGNSMDS-ESC-CGPRKTDNLQ-STQASSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYSSL------- ------------------------------------------------------------ - >ENSHGLP00000020088 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAVQFRSLFPLALPGMLALL-GWWWFF-LRKKQVSSSEE-Q---------AESG AVAL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RA---------------GPA TVEL-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPMEEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------PT-------VVFM----- ------------------------------------------------------------ ------------------------------------PPSVI------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QLTG----------------------QDESTASEPSME ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLQTNLPHRRAESSGSL- ------------------------------------------------------------ ---------PDSTDSRSQ----------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------NSPK -----------------------------------------VELAVMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EARS--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LACPLTFP------HETVQVY-KREPALGRVP----------ATEK HGP------------GEKAR---------------------------------------- ------------DREMGGAEGTGDAVLGGEVLDEGLLPQE-------------------- --------CVLELEN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------NKA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----LGPPLVVGAVGALSKGECAVWKSLSGV--VEPA----------------------- -----------------------------------------------------P------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------AELAREEE------------------------------------ -----------TPAPQITGGK----------------------------A---------- ------------------------------------------------------------ ------------------------------RDKDLV-ERG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------EALDDN--------- ------------------------------------------------------------ KKIEQAASQIISQVILKATEEV-------------------------------------- --------------------------LATTVGKTAE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LVDQAAAVQPQGQQEEKNCAPVS-------------------------- ----------------------------------------------------QETVSGQ- ------------DGVEPTPA---------------------------------------- ------------------------------------------------------------ -------------------------------------TAGEAAS----------P----- ------------------------------------------------------------ ---------------LSAALPSPGP----------LAGD--------------------- -----------------------LPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------RK-P KNSAHPISLAPCLP---------------------------------------------- ---------------------PD-TPLRE-------------------PL--------DE ASTP------------------------------VEDAT---CVTCM-SDSQN--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SSGQCSDSVSTSEL----------EDCCTETNSSPRDKAIITPQLPD-STEAFSNGLLKG ELSDVGTEDGW------------------------------------------------- --------------SVDAEADHSG----GSDGNSMDS-ESCGGGGRKTDSL--STQAGSD PKKVDLIVWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVSQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGLDG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDRFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYSSL------- ------------------------------------------------------------ - >ENSFDAP00000005944 ------------------------------------------------------------ ----------------------------------EATASLGTVLRSC------------- ------------------------------------------------------------ -------------------------------MLHTSR----------------------- ------MAVQFRSLFPLALPGMLALL-GWWFFS-RKKQQVSSSEE-Q---------AE-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------A---------------GPP TKEL-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------VPVEEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------HT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VVSTL-PT VTQP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------G----------------------KDEPTAGKPSME ------------------------------------------------------------ ------------------------------------------------------------ ------------------PS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALLRTHLPHRRAESSGSL- ------------------------------------------------------------ ---------PDTTEARSR----------------------------AG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------SK-ENSAK -----------------------------------------TELAVMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--A-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LGCPLAFP------HEAVQVC-KWEPTRGGMP----------ATEK RDP------------GEKAR---------------------------------------- ------------DGETGGAEGTSSAVLGEDMLEEGLLPQEHVLDPENDKPCSPARSGGRE EKGSGGLS---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------LVVGAVGALPKGECAVRKLLSGG--VEPA----------------------- -----------------------------------------------------P------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------TELAREEE------------------------------------ -----------TPAPQVTDGK----------------------------A---------- ------------------------------------------------------------ ------------------------------RDRGLV-ELG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------RE--------------------------------------- ---------------------------------------------DALDVN--------- ------------------------------------------------------------ KKIEQAAFQIISQVILEATEEV-------------------------------------- --------------------------LATTVGKPAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LVDQATASQPQGQQEEENCAPVS-------------------------- ----------------------------------------------------QETVPGQ- ------------DDVDPTPA---------------------------------------- ------------------------------------------------------------ -------------------------------------TAGQAAR---------------- ------------------------------------------------------------ ------------------------P----------LAED--------------------- -----------------------LPPP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------RK-P KNSAHPISLAPCPP---------------------------------------------- ---------------------PD-AHLGD-------------------PL--------DE ASTL------------------------------VEDAT---CVTCMSSDSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SSGRCSDSVSTSGF----------EDCCTETNSSPRDK-VITPPLPD-STEPFSNGVLKG ELSDVGTEDGW------------------------------------------------- --------------SVDAEADHSG----GSDGNSMDS-ESC-CGGRKTDNLQ-SAQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGVDG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRLLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSMSIP00000026972 MGCKTGPKPFGCG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------DTIRPIRIGRCSYF TSTDSKMAIQLRSLFPLALPGMLALL-GWWWFFSRKKDRLSSRDKQQ---------VET- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KV---------------GPA IKDR-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------RLSEEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VLSVA-PT VTQP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------REEQRSVDKPSTEPLALPRTRQVRRRSESSGNL- ------------------------------------------------------------ ---------PSVADTRSQ----------------------------PG-P---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-DENAK -----------------------------------------VELSLMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LGCPLL-PKDASFPYEAVERC-KQESALGKTPGRGWPSPYAAS--- ---------------GEKA----------------------------------------- -------------RETGGTEGTGDAVLGENVSEEGLLSQEC------------------- ---------VSEVEK--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SEFPIL-----APG-GGG GEEVSHG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVAELLKKEEYIVGKLP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SSFVEPVHSEPLKDEDALEPQVKD-SNT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SDRDLAGELD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KD--------------------------------------- ---------------------------------------------ETLPEN--------- ------------------------------------------------------------ DQIKQAAFQLISQVILEATEEL-------------------------------------- --------------------------RATTVGKTVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QVHPTSATQPKGKEE--SGVPAS-------------------------- ----------------------------------------------------QETALGQ- ------------DTPDP------------------------------ASTRTG-ATAS-- ------------------------------------------------------------ ------------------------------------------------------P----- -------------------------------------------------SAEAL------ ------------------------------------------------------------ -------------------------PP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSGPT-KD------------------------------------------------QK-P KNSARHISLAPCPP---------------------------------------------- ---------------------PL-TPQRQ-------------------SL--------EG ASNPRGD---------------------------------DNFVTCMANNSQS--VL--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVS SLGQCSDPVSTSGL----------EDSCTETISSSGDK-AITPPLPV-STQPFSNGVLKE ELSDLGTEDGW------------------------------------------------- --------------TMDTEADHSG----GSDGNSMDSVDSC-CGLTKPDSPQ-SVQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVVPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SATGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >MGP_SPRETEiJ_P0030554 MGCKTGPKPFGGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ETIRPIRIGRCSYF TSTDSKMAIQLRSLFPLALPGMLALL-GWWWFFSRKKDRLSSSDKQQ---------VET- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KV---------------GPA IKDR-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------RLSEEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VLSVA-PT VTQP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------REEQRSVDKPSTEPLALPRTRQVRRRSESSGNL- ------------------------------------------------------------ ---------PSVADTRSQ----------------------------PG-P---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-DENAK -----------------------------------------VELSLMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LGCPLL-PKDASFPYEAVERC-KQESALGKTPGRGWPSPYSAS--- ---------------GEKA----------------------------------------- -------------RETGGTEGTGDAVLGENVSEEGLLSQEC------------------- ---------VSEVEK--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SEFPIL-----APG-EGG GEEVGHG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVAELLKKEENIVGKLP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SSFVEPVHSEPLKDEDALESQVKD-SNT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SDRDLAGELD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KD--------------------------------------- ---------------------------------------------ETLPEN--------- ------------------------------------------------------------ DQIKQAAFQLISQVILEATEEL-------------------------------------- --------------------------RATTVGKTVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QVHPTSATQPKGKEE--SCVPAS-------------------------- ----------------------------------------------------QETGLGQ- ------------DTPDP------------------------------ASTRTG-ATAS-- ------------------------------------------------------------ ------------------------------------------------------P----- -------------------------------------------------SAEAL------ ------------------------------------------------------------ -------------------------PP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSGPT-KD------------------------------------------------QK-P KNSARHISLAPCPP---------------------------------------------- ---------------------PV-TPQRQ-------------------SL--------EG ASNPRGD---------------------------------DNFVTCMANNSQS--VL--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVS SLGQCSDPVSTSGL----------EDSCTETISSSGDK-AITPPLPV-SAQPFSNGVLKE ELSDLGTEDGW------------------------------------------------- --------------TMDTEADHSG----GSDGNSMDSVDSC-CGLTKPDSPQ-SVQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVVPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SATGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >MGP_CAROLIEiJ_P0029140 MGCKTGPKPFGGG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------ETIRPIRIGRCSYF TSTDSKMAIQLRSLFPLALPGMLALL-GWWWFFSRKKDRLSSSDK-Q---------VET- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KV---------------GPA IKDR-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------RLSEEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VLSVA-PT VTQP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------REEQRSVDKPSTEPLALPRTRQVRRRSESSGNL- ------------------------------------------------------------ ---------PSIADTRSQ----------------------------PG-P---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-DENAK -----------------------------------------VELSLMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LGCPLL-PKDASFPYEAVEGC-KQESALGKTPGRGWPSPYAAS--- ---------------GEKA----------------------------------------- -------------RETGGTEGTGDAVLGENISEEGLLSQEC------------------- ---------VSEVEK--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SEFPIL-----APG-GGG GEKVSHG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVAELLKKEEYIVGKLP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SGFVEPVHSELVKDEDALEPQVKDSSNT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SDRDLAGELD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KD--------------------------------------- ---------------------------------------------ETLPEI--------- ------------------------------------------------------------ DQIKQAAFQLISQVILEATEEL-------------------------------------- --------------------------RATTEGKTVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QVHPTSATQPKGKEE--SCVPAS-------------------------- ----------------------------------------------------QETGLGQ- ------------DTPDP------------------------------ASTRTG-ATAS-- ------------------------------------------------------------ ------------------------------------------------------P----- -------------------------------------------------SAEAL------ ------------------------------------------------------------ -------------------------PP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSGPT-KD------------------------------------------------QK-P KNSARHISLAPCPP---------------------------------------------- ---------------------PV-TPQRQ-------------------SL--------EG ASNPRGD---------------------------------DNFVTCMANNNQS--VL--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVS SLGQCSDPVSTSGL----------EDSCTETISSSGDK-AITPPLPV-STQPFSNGVLKE ELSDLGTEDGW------------------------------------------------- --------------TMDTEADHSG----GSDGNSMDSVDSC-CGLTKPDSPQ-SVQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVVPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SATGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSMUSP00000018572 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQLRSLFPLALPGMLALL-GWWWFFSRKKDRLSSSDK-Q---------VET- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KV---------------GPA IKDR-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------RLSEEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VLSVA-PT VTQP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------REEQRCVDKPSTEPLALPRTRQVRRRSESSGNL- ------------------------------------------------------------ ---------PSVADTRSQ----------------------------PG-P---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-DEIAK -----------------------------------------VELSLMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LGCPLL-PKDASFPYEAVERC-KQESALGKTPGRGWPSPYAAS--- ---------------GEKA----------------------------------------- -------------RETGGTEGTGDAVLGENVSEEGLLSQEC------------------- ---------VSEVEK--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SEFPIL-----APG-GGE GEEVSHG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVAELLKKEEYIVGKLP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SSFVEPVHSEPVKDEDALEPQVKGSSNT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SDRDLAGELD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KD--------------------------------------- ---------------------------------------------ETVPEN--------- ------------------------------------------------------------ DQIKQAAFQLISQVILEATEEF-------------------------------------- --------------------------RATTVGKTVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QVHPTSATQPKGKEE--SCVPAS-------------------------- ----------------------------------------------------QETSLGQ- ------------DTSDP------------------------------ASTRTG-ATAS-- ------------------------------------------------------------ ------------------------------------------------------P----- -------------------------------------------------SAEAL------ ------------------------------------------------------------ -------------------------PP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSGPT-KD------------------------------------------------QK-P KNSAHHISLAPCPP---------------------------------------------- ---------------------PV-TPQRQ-------------------SL--------EG ASNPRGD---------------------------------DNFVACMANNSQS--VL--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVS SLGQCSDPVSTSGL----------EDSCTETISSSGDK-AMTPPLPV-STQPFSNGVLKE ELSDLGTEDGW------------------------------------------------- --------------TMDTEADHSG----GSDGNSMDSVDSC-CGLTKPDSPQ-SVQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVVPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SATGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >MGP_PahariEiJ_P0035852 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQLRSLFPLALPGMLALL-GWWWFFSRKKDQLSSSDK-Q---------AET- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KV---------------GPT IKDR-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPSEEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VLSVA-PT VTQP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------KEEQRSVDKPSTEPLALPRTRQVQRRSESSGNL- ------------------------------------------------------------ ---------PSIADTRSQ----------------------------PG-P---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-DENAK -----------------------------------------VELSLMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KARS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LGCPLL-PRDASFPYEAVEGC-KQESALGKTPGRGWPSLYAAS--- ---------------GEKA----------------------------------------- -------------RETGGTEGTGDAVLGENVSEEGLLSQEC------------------- ---------VSEVEK--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SEFPIP-----ATGIGGG GEEVSHG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVAELLKKEDYIVGKLP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SSFVEPVHSELVKDEDALVPQVRG-SST------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SDRDLAGELD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------RD--------------------------------------- ---------------------------------------------EPLPEN--------- ------------------------------------------------------------ DQIKQVAFQLISQVILEATEEI-------------------------------------- --------------------------RATTVGKTVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QVHPTSATQPKRKEG--SCVPAS-------------------------- ----------------------------------------------------QETGLGQ- ------------DAPDP------------------------------ASTSTG-ATAS-- ------------------------------------------------------------ ------------------------------------------------------P----- -------------------------------------------------SAEAL------ ------------------------------------------------------------ -------------------------PP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RSP LLGPT-KE------------------------------------------------QK-P KNSAHHISLAPCPP---------------------------------------------- ---------------------PV-TPQRQ-------------------SL--------DG ASNPRGD---------------------------------DTFVTCMASNSQS--VL--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVS SLGQCSDPVSTSGL----------EDSCAETLSSSGDK-AITPPLPV-GTEPFSNGVLKE ELSDLGTEDGW------------------------------------------------- --------------TVDTEADHSG----GSDGNSMDSVDSC-CGLTKPDSPQ-SVQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEDTNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVVPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SATGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSRNOP00000052543 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKDRLSSNGK-Q---------VGT- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KV---------------GPA IEDR-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPTEEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VLSVT-PS VTQP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------KEEQRSMDRPLTDPPALPRTRQVRRRSESSGNL- ------------------------------------------------------------ ---------PSIVDTRLQ----------------------------AG-Q---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-DENSK -----------------------------------------VVLSLMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LGRPLF-PKDLSFPYEAVEGC-KQESALGRTPGRGWLSQCAAS--- ---------------GENA----------------------------------------- -------------RETGGAEGTGDAVLGESVLEEGLLPQEC------------------- ---------VSEVEK--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SEFPIL-----APG-GGG GEKVRSG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVDELLKKEEYIVGKLP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SSFVGPVHSELVKDEGALVPQVKG---S------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QDRSLARELD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KD--------------------------------------- ---------------------------------------------KTLPEK--------- ------------------------------------------------------------ DQIEQTAFQIISQVILEATEEI-------------------------------------- --------------------------RATTVGKTVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QVHPTPGTQPQGQEE--SCVPAS-------------------------- ----------------------------------------------------QETSLGQ- ------------EIPDP------------------------------ASTRTG-ATAS-- ------------------------------------------------------------ ------------------------------------------------------P----- -------------------------------------------------SAGAP------ ------------------------------------------------------------ -------------------------PP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSGPT-KD------------------------------------------------QK-P KNSAHHISLAPCPP---------------------------------------------- ---------------------PV-TPQRQ-------------------SL--------DG ASNPRGD---------------------------------DTFVTCTSNNSQS--VL--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVT SLGLCSDPVSTSRL----------EDSCTETISSSGDK-AVTPPLPD-STEPFSNGVLKE ELSDLGTEDGW------------------------------------------------- --------------TMDTEADHSG----GSDGNSMDSVDSC-CGLTKPDSPQ-TVQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVVPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SATGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSCYASL------- ------------------------------------------------------------ - >ENSMUGP00000013686 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLIPLALPGMLALL-GCWWFFSRKKGRLSSKEK-Q---------VET- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KI---------------SPA IKDR-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPSEEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VLSVP-PR VTQP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEQLFVVRSSAE ------------------------------------------------------------ ------------------------------------------------------------ ------------------TP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALPRARQVRRRSESSGNL- ------------------------------------------------------------ ---------PSNIDTRLQ----------------------------PG-P---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-SENSK -----------------------------------------VELSLIGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------HGYPLF-PKDVPFPCEAVEGC-KQGSALGKGPGRGRLSQCAAS--- ---------------GEKT----------------------------------------- -------------RETGGTEGTGDAVLGEGVPEEGLLSQEC------------------- ---------FSEVKK--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SEVPSL-----APW-GAG GEKVSSA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVAELAKKEEYVVEKL------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PVHSELVKDEDALVPQVRG---S------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------STQDLARELD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KD--------------------------------------- ---------------------------------------------ETVPEN--------- ------------------------------------------------------------ DPIEQAAFQIISQVILKATKEV-------------------------------------- --------------------------EATTVGTTVT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QVHPTSATQPQGQEE--SCVPDS-------------------------- ----------------------------------------------------QGTGLGQ- ------------DTPDP------------------------------ASTTTG-ATAS-- ------------------------------------------------------------ ------------------------------------------------------P----- -------------------------------------------------SAEAL------ ------------------------------------------------------------ -------------------------PP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSGPT-KD------------------------------------------------QK-P KNSARHISLAIFPP---------------------------------------------- ---------------------PV-TPQRP-------------------SL--------DG ASDLGGD---------------------------------DTFVTCTSNNGQS--VL--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVT TSGRCSDSVSTLGL----------EDSCTETISSPGDK-AVSLPLAD-STEPFSNGLLKE GLSDLGADDGW------------------------------------------------- --------------TVDTEADHSG----GSDGNSMDSVDSC-CGLTKPDSPQ-NVQADAN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVKQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVVPLS------------------------DDDHFSPEADAAMSEMTGNAALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SATGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYASL------- ------------------------------------------------------------ - >ENSMOCP00000010427 MGGKTGPKPIGGGGTLRTKLAIRECSLCNQTQTH-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKDRLSRSDE-Q---------IET- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KV---------------GPA IKVR-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPSEEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TK ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VLSVP-LS VAQP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------LEQLSVGKSSIE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALPRTRQVRRRSESSGCL- ------------------------------------------------------------ ---------PSNVDTRSQ-------------------------------P---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-DDNSK -----------------------------------------MELSLMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--V-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LGCSLL-PKEVPFPLEAVEGY-KQDSALGKTPGRGWLGQCAAS--- ---------------GEKA----------------------------------------- -------------RETGRAEGTGDAVLGESVPEEVLLSQEC------------------- ---------ISEAKK--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SEVPSL-----APW-GGG GEKVSRG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVTELAKKEECVVGKLP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------GSFAEPVHSELVKDEDVLVPQVRG-SNT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------WNRDLASEQV-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------ETLPKN--------- ------------------------------------------------------------ DQIEQAAFQIISQVILEATEEM-------------------------------------- --------------------------RATTMGKTMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QVHPTPATQPQELEE--SSVPAS-------------------------- ----------------------------------------------------QETGLGQ- ------------DTPDP------------------------------ASGTN--ATDS-- ------------------------------------------------------------ ------------------------------------------------------P----- -------------------------------------------------LAEAL------ ------------------------------------------------------------ -------------------------PP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------QK-P KNSAHHISLAPCPA---------------------------------------------- ---------------------PV-PLRRQ-------------------SL--------DG AGSPGGD---------------------------------DTFVTCMSNNRQG--VL--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVT TSGPCSDSLSTSGF----------EDSCTETNSSPGDK-AVTPPLPD-STEPFSNGVLKE EFSDLGTEDGW------------------------------------------------- --------------TMDTDADHSG----GSDGNSMDSVDSC-CGLTNPDSLQ-NAQASSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQI---------- ------------SSLQVTRLFCPSECLNTPFSFSSLQDDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TRY-STTGLPLIRLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYANL------- ------------------------------------------------------------ - >ENSCGRP00015007545 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKDQLSSNDK-Q---------VET- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KV---------------GPV IKDQ-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPSDEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PR ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VLSMP-PS VAQP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------TEQLSVGKSST- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALPRIRQVRRRSESSGNL- ------------------------------------------------------------ ---------PSNVDTRSQ-------------------------------P---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-DNNSK -----------------------------------------VELSLMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EVKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LGCPLL-PKEVPFPYEAVEGY-KQESALGKIPGRGWLDQCAAS--- ---------------GEKA----------------------------------------- -------------RETGGAEGTGDAVLGENIPEEGLLSQEY------------------- ---------ISEVEK--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SGVPNL-----APW-GGG GEKMSSG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVAELAKKEEFVVGKLP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SSFVEPVRSEMVKDEDALVPQVRG-GIT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QDRDLAREQI-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------DTLPEK--------- ------------------------------------------------------------ DQIEQAAFQIISRVILEVTEEM-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------GAGKTVVQVYPTSVAQPQGLEESSVP A--------------------------------------------------SQETGLGR- ------------DIPDP------------------------------VSTTTG-ATAS-- ------------------------------------------------------------ ------------------------------------------------------P----- -------------------------------------------------PAEAL------ ------------------------------------------------------------ -------------------------PP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CF--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------QK-P KTSAHHISLAPCPL---------------------------------------------- ---------------------PV-TRLRQ-------------------SL--------DA ASSPGGD---------------------------------DTFVTCMSYNKQS--VL--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVT SSGQRSHSLTTSGL----------EDSCTKTISSPGDK-AVTPPLPD-STEPFSNGVLKE ELSDVGTEDGW------------------------------------------------- --------------TMDAEADHSG----GSDRNSMDSVDSC-CGLPKPDSLQ-NVQASSN PKKVDLIVWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVVPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SETGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYANL------- ------------------------------------------------------------ - >ENSCGRP00001004233 M----------------------------SSQLHYVKS---------------------- ------------------------------------------------------------ -------------------------------ICR-------------------------- ----NCPSP--------------------------AETLVPLLHLAS------------- -----KMAIQFRSLFPLALPGMLALL-GWWWFFSRKKDQLSSNDK-Q---------VET- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KV---------------GPV IKDQ-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPSDEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PR ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VLSMP-PS VAQP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------TEQLSVGKSST- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALPRIRQVRRRSESSGNL- ------------------------------------------------------------ ---------PSNVDTRSQ-------------------------------P---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-DNNSK -----------------------------------------VELSLMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EVKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LGCPLL-PKEVPFPYEAVEGY-KQESALGKIPGRGWLDQCAAS--- ---------------GEKA----------------------------------------- -------------RETGGAEGTGDAVLGENIPEEGLLSQEY------------------- ---------ISEVEK--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SGVPNL-----APW-GGG GEKMSSG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVAELAKKEEFVVGKLP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SSFVEPVRSEMVKDEDALVPQVRG-GIT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QDRDLAREQI-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------DTLPEK--------- ------------------------------------------------------------ DQIEQAAFQIISRVILEVTEEM-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------GAGKTVVQVYPTSVAQPQGLEESSVP A--------------------------------------------------SQETGLGR- ------------DIPDP------------------------------VSTTTG-ATAS-- ------------------------------------------------------------ ------------------------------------------------------P----- -------------------------------------------------PAEAL------ ------------------------------------------------------------ -------------------------PP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CF--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPT-KD------------------------------------------------QK-P KTSAHHISLAPCPL---------------------------------------------- ---------------------PV-TRLRQ-------------------SL--------DA ASSPGGD---------------------------------DTFVTCMSYNKQS--VL--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVT SSGQRSHSLTTSGL----------EDSCTKTISSPGDK-AVTPPLPD-STEPFSNGVLKE ELSDVGTEDGW------------------------------------------------- --------------TMDAEADHSG----GSDRNSMDSVDSC-CRLPKPDSLQ-NVQASSN PKKVDLIVWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNVQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVVPLS------------------------DDDHFSPEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SETGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYANL------- ------------------------------------------------------------ - >ENSPEMP00000027675 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKDRLSSNDK-Q---------VET- ---L-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KV---------------GPA IKDR-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LPSEEAC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PK ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VLSVP-LT VTQP--------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------TEQLSMSKSSTE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALPRSRQVRRRSESSGSL- ------------------------------------------------------------ ---------PSNIDTRSQ-------------------------------P---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CR-DDNSK -----------------------------------------VELSLMGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKS--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------P- --------------LGCPLL-PKDVPFPFEAAEEC-KQESALGKTPGRGWLGQCAAS--- ---------------GEKA----------------------------------------- -------------RETGGVEGNGDAVLGENVPEEGLLSQEC------------------- ---------GSEVEK--------------------------------------------- ------------------------------------------------------------ ------------------------------------------SEIPSL-----APW-GGG GEEVSNG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PPQVAELAKKKEYVVGKLP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SSFVEPVHSELVKDEHALVPQVRG-SDT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------WDRDLPREQV-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------KE--------------------------------------- ---------------------------------------------ETLPKN--------- ------------------------------------------------------------ DEIEQAAFQIISQVILEATEEM-------------------------------------- --------------------------RATTMGKAMA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QVHPTSATRPQELKE--TCVPAI-------------------------- ----------------------------------------------------QETGLGQ- ------------DPPDP------------------------------VSTTPG-AAAS-- ------------------------------------------------------------ ------------------------------------------------------P----- -------------------------------------------------LAEAL------ ------------------------------------------------------------ -------------------------PP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LTSPT-KD------------------------------------------------QK-P KISAHHISLAPCPS---------------------------------------------- ---------------------PV-TRLRQ-------------------SL--------DG ASSPGGD---------------------------------DTFVTCMSNNRPS--VL--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVT SSGPCSDSLSTSGL----------EDSCTETISSPGGK-GITPPLPD-STEPFSNGVLKE EFSDLGTEDGW------------------------------------------------- --------------TMDTEADHSG----GSDGNSMDSVDSC-CGLTKPDSLE-NVQASSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVVPLS------------------------DDEHFSAEADAAMSEMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-STNGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSYYANL------- ------------------------------------------------------------ - >ENSJJAP00000005371 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------PIPSYLALVTPLSSPLALPRHSYITHTSE----------------------- ------MAIQFRSLFPLALPGMLALL-GWWWFFSRKKERVSSTD---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PQTEAGGVALMAGPAIKDPLLKEEVCLRGTSMVSSVAQLP----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------E----------------------KEQLCASKPSEE ------------------------------------------------------------ ------------------------------------------------------------ ------------------PP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ALSRTRTVPRRSESSGSL- ------------------------------------------------------------ ---------PNASDARSQ----------------------------PG-Q---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GR-DHSMK -----------------------------------------VEFALIGD----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EAKP--I-------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------T- --------------LECPLQPPKDVLFPHEA-EVC-KQESSLGRVPGRGWPGHSAAP--- ---------------GEKA----------------------------------------- -------------RETGRAEGTGDAVLGENVLEEDRLSQDC------------------- ---------VSELEKNKAQSPAPLGGRGEERSGSPLHMVK-------------------- ---------PAQ-------------KEEQVAGKAL------------------------- ------SSFAESG-----HPELAKDAE--------------TS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------VPLVRG-SNG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------WDRELG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------RE--------------------------------------- ---------------------------------------------ETWDKN--------- ------------------------------------------------------------ KQIEQTAFQLISQVILEATEEV-------------------------------------- --------------------------RATAVDRTVG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QVHSASAMQPHTQEE--SCASAS-------------------------- ----------------------------------------------------QKTVLGQ- ------------DTTEP------------------------------ASATAGLATGP-- ------------------------------------------------------------ ------------------------------------------------------P----- ---------------------------------------------------EDL------ ------------------------------------------------------------ -------------------------PP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KTYVS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -CL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP LSSPS-KD------------------------------------------------EK-P KNSAHHISLAPCPP---------------------------------------------- ---------------------PA-SPVEG-------------------SL--------DG ASTVEGDT--------------------------------STSVSCMSHHSQS--VP--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SVA SLEQCSDSVSTSGL----------EDSCTETSSSPREK-AISPPLPD-STEPFSNGVLKG ELSDLGAEDGW------------------------------------------------- --------------TMDTDADHSG----GSDGNSMDSVDGC-CGLRKPDSLQ-NVQAGSN PKKVDLIIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQNIQICHIEGS QHHVDKALNLIGKKFKELNLTNIYAPPLPS-LA---LPSLPMTSW--------------- LMLPDGVTVEVIVVSQVDAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGTPTLPTPVEI TVICAAPGADG-AWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQ GAEVLLDSVMPLS------------------------DDDHFSPEADAAMREMTGNTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TSY-SPTGLPLIQLWSVVGDEV------------------------------ -----------------------------VLINRSLVERGLA-QWVDSCYASL------- ------------------------------------------------------------ - >ENSCCEP00000023509 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRNFVPYAIPGVLALL-GCWWIYSWRKKHSGYRNK-Q---------AIAI EREKREEVSESDSCPKPEACVPRR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LPPL-----------------------------LEEVC-------- ------------------------------------------------------------ ----------------------------------------------------------LE KPAPTSLLSAGPMT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SLLHP----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------AHE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GPDLSRDL- ------------------------------------------------------------ ---------PDLSATTAG----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RE-DDSEQ -----------------------------------------LESIGSRGGSGVRACASL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LLAESTEC----------DQNAVLSH TL--GQGLGANQ---------------------------------------------G-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QQP-------------------LLTQE S----------------------------------------------------------- -LGAREDIYNTEQSDESSF----------KPPK--------------------------- -------------------------------EKQMSG----------------------- ----------------------IVQSDSGSVTACSLGLEKEANAPQAFLS-EA-EVVSGH KDSAVSALPVS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------SESACPKQSREEE--------------------MSKSITGTIPVCQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---KDTQTKGDELE---------------------------------------------- ------------------------------------------------------------ -------------------RE----KI-EV-----------------------------S LDK----------------------------------------------EV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LSGSVGSASP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------WLCQATASQ---------------------------------------- --------------------------------------AEA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------L----------------------- -----------------------GMESVA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ASGQEL ------------------------------------------------------------ ------------------------------------------------------------ --------------VEG--ATAADG--------SVAAGSSAEEQGQGATD---------- --------------------------------------------------------CSSH GCW--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ASP VQGNT-ED------------------------------------------------CQ-V KSWVC------------------------------------------------------G ESQGVDRTHVEN------------------------------------SL--------EE SPLT------------------------------MEDSG---YGTHTPGGGTS--VE--E P-LQSTV----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV TSDQHSDSLSTSSA----------PETSAEQSLVPREP-PSAPGLPKGSTVPYSNGILKE DGPDLSQECSS------------------------------------------------- --------------APGTDGDHSE----GSDVNSVDFVDSG-SAMRKTVARQ-NAKLEGG SSKPDFVIWEIEVP-KELVGRLIGKQGRFMSYLRQASGAKIYVSTLPYFRDSQVCHIEGT SHQVEKVLSLIGKKFKELCLTNIYTLPPPMPLP---LHSLLVSAW--------------- LFLPDGVTVEVVVAHQVDAGHMFLQQHTHPTFHVLRSLDQQMFACYSQPEIPTLPTPVEV GIICAAPGLDG-AWLRAQVISYFEETDEVELKYVDYGGYDKVKVDTLRQIRSDFLTLPFQ GAEVLLDNVVPLP------------------------DEDHFSPEADSAVSEMTRGAVLV A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSVTGLPLIQLWSLMGDEV------------------------------ -----------------------------VSINRTLVERGFA-RWLD-Y----------- ------------------------------------------------------------ - >ENSPMJP00000027287 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRNFVPYAIPGVLALL-GCWWIYSWRKKHSGYRNK-Q---------AIAI EREKREEVSESDSCPKPEACVPQR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LPPL-----------------------------LEEVC-------- ------------------------------------------------------------ ----------------------------------------------------------LE KPAPTSLLSAGPMT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SLLHP----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------ADE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GPDLSRDL- ------------------------------------------------------------ ---------PDLSAATAG----------------------------PG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RE-DDSEQ -----------------------------------------LESIGSRGGSGVPACASL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LLAESTEC----------DRNAVLSH TL--GQGLGAKQ---------------------------------------------G-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QQP-------------------LLTQE P----------------------------------------------------------- -LGAREGICNTEQSDESSF----------KPPK--------------------------- -------------------------------EKQMSG----------------------- ----------------------IVQSDSGSVTACCLGLEKEANAPQAFLS-EA-EVVSGH KDSAVSALPVS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------SESACPKQSREEE--------------------MSKSITGTIPVCQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---KDTHPKGDELE---------------------------------------------- ------------------------------------------------------------ -------------------RE----KI-EV-----------------------------S LDK----------------------------------------------EV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LSGSVGSTSP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------WLCQATASQ---------------------------------------- --------------------------------------AEA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------L----------------------- -----------------------GMESVA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ASGQEL ------------------------------------------------------------ ------------------------------------------------------------ --------------VEG--ATAADV--------SVAAGSSAEEQGQGATD---------- --------------------------------------------------------CSSH GCW--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ASP VQGNT-ED------------------------------------------------CQ-V KSWVC------------------------------------------------------G ESQGVDRTRVEN------------------------------------SL--------EE SPFT------------------------------MEDSG---YGTHTPGGGTS--VE--E P-LQSTV----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV TSDQHSDSLSTSSA----------PDTSAEQSLVPREP-PSAPGLPEGSTVPYSNGILKE DGPDLSQECSS------------------------------------------------- --------------APGTDGDHSE----GSDVNSVDFVDSG-SAMRKTVARQ-NAKLEGG SSKPDFVIWEIEVP-KELVGRLIGKQGRFMSYLRQASGAKIYVSTLPYFRDSQVCHIEGT SHQVEKVLSLIGKKFKELCLTNIYTLPPPMPLP---LHSLLVSAW--------------- LFLPDGVTVEVVVAHQVDAGHMFLQQHTHPTFHVLRSLDQQMFACYSQPEIPTLPTPVEV GIICAAPGLDG-AWLRAQVISYFEETDEVELKYVDYGGYDKVKVDTLRQIRSDFLTLPFQ GAEVLLDNVVPLP------------------------DEDHFSPEADAAVSEMTRGAVLV A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSVTGLPLIQLWSLMGDEV------------------------------ 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--------------LPLL-----------------------------SEEEF-------- ------------------------------------------------------------ ----------------------------------------------------------LE KPAP-------LTT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SLLHP----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------AQE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------RPDLSWEP- ------------------------------------------------------------ ---------SDLSATTAG----------------------------PS-P---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------CE-DDSEK -----------------------------------------LESVGSREGSDSPAPASL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LLSGSAEY----------DQNVVLSH AL--GQGSGANQ---------------------------------------------G-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QQP-------------------SLTPE S----------------------------------------------------------- -LGVTEDISNTEQSDESSC----------KPPK--------------------------- -------------------------------EKQMPG----------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ASP VQGNT-ED------------------------------------------------CQ-A KSWVC------------------------------------------------------R ESQGVGRTRVEN------------------------------------SL--------EK SPLS------------------------------MEDSG---YGTHTPGGGTS--AE--E P-LQSTV----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV TSDQHSDSLSTSSA----------PDTSAEQSLVPRET-PCAPGLPEGSTVPYSNGILKE DGPDLSQECSS------------------------------------------------- --------------APGTDGDHSE----GSDVNSVDFVDSG-SAMRKTVARQ-NAKLEGG SSKPDFVIWEIEVP-KELVGRLIGKQGRFMSYLRQASGAKIYVSTLPYLRDSQVCHIEGT SHQVEKVLSLIGKKFKELCLTNIYSLPP--PMP---LHSLLVSAW--------------- LFLPDGVTVEVVVAHQVDAGHMFLQQHTHPTFHVLCSLNQQMFACYSQPDIPTLPTPVEV 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VPLL-----------------------------SEEEC-------- ------------------------------------------------------------ ----------------------------------------------------------LE QPAPSSLLPVGLTM---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SALHP----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------AHE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GPELSRDP- ------------------------------------------------------------ ---------PDLPATAAG----------------------------PS-P---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------K--DDSEQ -----------------------------------------LESVGSGEGSGVPARASL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VLAGSSEC----------DQSV---- AL--GQGSGTNQ---------------------------------------------G-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QQP-------------------PLTQE S----------------------------------------------------------- -LGVTEDTSNTEQSDESSF----------KPPK--------------------------- -------------------------------EKQMPG----------------------- ----------------------IVQSATGSVTACCLGLEKEAGAPQAFLN-EG-E-VSGH EVSAVSVLPGS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------LESTCPKQSREEE--------------------MSESITGTVPVCQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---KDTQPKGDELE---------------------------------------------- ------------------------------------------------------------ -------------------RE----KIGGV-----------------------------S LDK----------------------------------------------EV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LSGSAGDASP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------WLCQ--ASR---------------------------------------- --------------------------------------AEA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------L----------------------- -----------------------GMESVA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ASAQVP ------------------------------------------------------------ ------------------------------------------------------------ --------------VEG--ATAADE--------GVAAG----EHGQGVTD---------- --------------------------------------------------------CSSH GCW--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ASP VQGRT-ED------------------------------------------------CQ-V KSCVC------------------------------------------------------R ESQGVGRTHVEN------------------------------------SL--------EK SPLS------------------------------MEDSG---YGTHTPGGGMS--VE--E P-LQSTV----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV TSEQHSDSLSTASA----------PDTSAEQSLLPRET-PSAAGLPEGSTVPYSNGILKE 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------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SPLHP----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------AHE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GPELSRGP- ------------------------------------------------------------ ---------PDLPATAAG----------------------------PS-P---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------K--DDSEQ -----------------------------------------LESVGSGEGSGVPARASL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VLAGSSEC----------DQSV---- 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------------------------------------------------------------ ------------------------------------------------------------ ---KDTQPKRDELE---------------------------------------------- ------------------------------------------------------------ -------------------RE----KIGGV-----------------------------S LDK----------------------------------------------EV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LSGSAGDASP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------WLCQ--ARR---------------------------------------- --------------------------------------AEA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- 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SPLS------------------------------MEDSG---YGTHTPGGGMS--VE--E L-LQSTV----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV TSEQHSDSLSTASA----------PDTSAEQSLVPREA-PSAAGLPEGSTVPYSNGIPKE DGPDLSQECGS------------------------------------------------- --------------APGTDGDHSE----GSDVNSVDFVDSG-SAMRKTVARQ-NAKLEGG SSKPDFVIWEIEVP-KELVGRLIGKQGRFMSYLRQASGAKIYVSTLPYFRDSQVCHIEGT SQQVEKVLSLIGKKFKELCLTNIYTLPPPMPMP---LHSLLVSAW--------------- LFLPDGVTVEVVVAHQVDAGHMFLQQHTHPTFHVLRSLDQQMFACYSQPEIPTLPTPVEV GIICAAPGLDG-AWLRAQVISYFEETDEVELKYVDYGGYDKVKVDTLRQIRSDFLTLPFQ GAEVLLDNVVPLP------------------------DEDHFSPEADAAVSEMTRGAVLV A-----------Q-VQPLSGEALLLVALLVSSALHCVLHKPTARAWLLASAGAGNSHQHC LELEGMCSLLFVVQAGGREPGYGYRAQQGLVPSRSGVPWVCTALPVLPGFAPWTCGIWLQ LARGSTVW---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ - >ENSSCAP00000015971 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRNFVPYAIPGVLALL-GCWWIYSWRKKHSGYYNK-Q---------AIAI AREKQEEVSESGARPKPEACVPRR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VPLL-----------------------------SEEEC-------- 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------------------------------------------------------------ ---------------------------------------------------RPHLSRDP- ------------------------------------------------------------ ---------PDLSATTAG----------------------------PS-P---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RE-DDSEQ -----------------------------------------LELVGSREGSGVPARASL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LLSGSSEC----------DQNM---- VL--GQGSAANQ---------------------------------------------G-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QQP----------------------QE S----------------------------------------------------------- -LGVTEDISSTEQSDESSF----------KPPK--------------------------- -------------------------------EKQMPG----------------------- ----------------------IVQSDTGSVTACCLGLEKEASTPQASLS-EA-E-VSGH 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------------------------------------------------------------ ---------------------------------------------------------ASP VQGST-ED------------------------------------------------CQ-V KSCVC------------------------------------------------------S ESQGVGRTHVEN------------------------------------SL--------EK SPLS------------------------------MEDSG---YGTHTPGGGTS--VE--E P-LQSTV----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV TSEQHSDSLSTSSA----------PDTSAEQSLVPGET-PSAPGLPEGSTVPYSNGILKE DGPDMSQECSS------------------------------------------------- --------------APGTDGDHSE----GSDVNSVDFVDSG-NAMRKTVARQ-NAKLEGG SSKPDFVIWEIEVP-KELVGRLIGKQGRFMSYLRQASGAKIYVSTLPYFRDSQVCHIEGT SHQVEKVLSLIGKKFKELCLTNIYTLPPPMPLP---LHSLLVSAW--------------- LFLPDGVTVEVVVAHQVDAGHMFLQQHTHPTFHVLRSLDQQMFACYSQPEIPTLPTPVEV GIICAAPGLDG-AWLRAQVISYFEETDEVELKYVDYGGYDKVKVDTLRQIRSDFLTLPFQ GAEVLLDNVVPLP------------------------DEDHFSPEADAAVSEMTRGAVLV A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSVTGLPLIQLWNLMGDEV------------------------------ -----------------------------VSINRTLVERGFA-RWLD-Y----------- ------------------------------------------------------------ - >ENSFALP00000005173 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRNFVPYAIPGVLALL-GCWWIYSWRKKHSGYCSQ-Q---------AIAI EREKQEAVPESGSRPKAEACVPRR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LPAL-----------------------------SEQEC-------- ------------------------------------------------------------ ----------------------------------------------------------LQ KPAPS------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------PA-PSPAP------ ------------------------------SPAPSPP---------TTPSPL-------- ---------------------------------------RPA--------LERPDLP--- ------------------------------------------------------------ ----------RDLPRDPPGLSAA-----------------------TATPCPRQ-DDSEK -----------------------------------------LESIGCGEGSAVPARASLP LPSEST---------------------------------ER------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DHGVLGP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AL--GQGSGANP---------------------------------------------G-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QQP-------------------PLARE T----------------------------------------------------------- -LGVREDSSSTEQLDESSF----------KPPK--------------------------- -------------------------------EKQMPG----------------------- ----------------------IVQSDAGSVTACCLGLEKEASAPQAFLN-EA-EIVSGH EDSAVSVLPGS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------SESACPKQSREEE--------------------MSESITGTVPVCQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---KDTQPKGDELE---------------------------------------------- ------------------------------------------------------------ -------------------RE----KIGGV-----------------------------S LDK----------------------------------------------EV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LSGSAGDASS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------WLCQAAASQ---------------------------------------- --------------------------------------AEA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------L----------------------- -----------------------GMESVA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ASAQVL ------------------------------------------------------------ ------------------------------------------------------------ --------------VEG--ATAADE--------SAAAGSSAEEQGQGVTD---------- --------------------------------------------------------CSSH GCG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ASP VQENM-ED------------------------------------------------CG-V KSQAC------------------------------------------------------R ESPGVGRTHVEN------------------------------------SL--------EK SPVA------------------------------LEDSG---YGTHTPGGETS--VE--E P-LQSTV----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV TAEQHSDSLSTSSA----------PDTSAEQSLVPGES-PCAPGLPEGSTVPYSNGILRE EGPEPSQECSS------------------------------------------------- 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------------------------------------------------------------ ----------------------------------------------------HE-DDSEK -----------------------------------------LERIGSQEESGAPARAPLP ----------------------------------------R----------VP------- ------------------ESAELSQAQ--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------GSSPS--AD------------------------------------- ------------------------------------------------------------ ---------------------------------------------------RD------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QQPS-----------------APLAQE S----------------------------------------------------------- -LGAKVEISNAEQSDESAF----------KPPE--------------------------- -------------------------------EKQMPE----------------------- ----------------------IVQSDTGSVTAHCLGLEKETNAPQAFVSKEA-EVVSSH EDSAVKMLPGS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------LEPACLKQSRDEE--------------------MPESI-ASVPVGR--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EDTQPKGDELE---------------------------------------------- ------------------------------------------------------------ -------------------RE----KIGGV-----------------------------S LDK----------------------------------------------EV--------- ------------------------------------------------------------ EKIEQVAIQFISKVILAATEEV-------------------------------------- --------------------------LSGSAGEVSPRTYQATAGRAEAALGAGSGAAPGA GSGAALGWGLAEGAAA------------EGTPLP---------TP--------------- ----PQAE---------------EQDQGATG----------------------------- ---------SS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------CPAH GCA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ASS GQGDT-GD------------------------------------------------CG-V KSCEG------------------------------------------------------R ESQGVDRTRVENHRG---------------------------------PL--------KK SSVA------------------------------LEDSG---YSTHTSEGGTS--VE--D 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LVSKSAQCHSSAVISPQQDS------ ------SSAATE---------------------------------------------G-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRPSA---------------LVTLTRE S----------------------------------------------------------- -SGILEEVSNAEQSNDSLF----------KPPK--------------------------- -------------------------------ENQMPE----------------------- ----------------------TVLADPGSVTALHLGLEKEASTPLAFHGNEV-EAVASH RDSAVGMLSDS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------CMKSTCLEPSREEE--------------------MSESIDSSVPVCQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EDTQPKGD------------------------------------------------- ------------------------------------------------------------ --------------------E----RIEGV-----------------------------G LDK---------------------------------------------EEV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LSGSVSDVSS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RICQAAASR---------------------------------------- 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---------------------------------------------------------SSP VQGDP-EE------------------------------------------------RQ-V KNCVH------------------------------------------------------S GSPGVARTPIASHGG---------------------------------SL--------GE SHVV------------------------------MEDSG---CSTCASEDGTS--IE--D P-LQNTM----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSG TSGEHLDSLSTSAT----------QDTSAEQSSVPSEK-PPTPKLPEDSQVLYSNGMLKE DSSDLRHESNW------------------------------------------------- --------------TAETDGDHSG----GSDVNSMDSVDSG-CALGKMETRQ-NSKPGGE ASKSELTIWEIEVP-KHLVGRLIGKQGRYVSYLKQTSGAKIYISTLPYTQDFQICHIEGS QHHVDKALSLIGKKFKELSLTNIYAPPPPS-LM---FHPLPMTSW--------------- LLLPDGVTVEVIVVNQINAGHMFVQQHTHPTFHVLRSLDQQMYVCYTQPGIPTLPTPVKV GVICAAPGLDG-AWWRAQVVGYFKESNEVEIRYVDYGGYDRVKVDTLRQIRSDFVTLPFQ GAEVLLDNVVPLP------------------------DEDHFSSEADTAVSEMTRGTALL 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LPLS-----------------------------SEEER-------- ------------------------------------------------------------ ----------------------------------------------------------PE NETSTSVLSAGSTT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SLLHQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------THE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------RLDFSQDL- ------------------------------------------------------------ ---------PAPAVMTIQ----------------------------PS-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LE-DDSEK -----------------------------------------LERIDSQDESSVPACVSL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LVSKSAKCHSSAVISPKQDS------ ------SSSATE---------------------------------------------G-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QWPSA---------------SVTLTRE 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------------------------------------------------------------ --------------------------------------------------------CLTH GRL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP AQGDP-KD------------------------------------------------RQ-V KNCVH------------------------------------------------------S ESPGVGRTPTANHGG---------------------------------SL--------GE SHVV------------------------------MEDSG---CSTCASEDGTS--VE--D P-LQNTM----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV TSGQHSDLLSTSAT----------QDTSAEQSSVPSEK-PSTPKLPEDSKVPYSNGMLKE DSPDLRHESNW------------------------------------------------- --------------MTETDGDHSG----GSDVNSMDSVDSG-CALGKTETRQ-NSKPAGE 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QWPSA---------------SVTLTRE S----------------------------------------------------------- -SGIMEEVSNAEQSNDSSF----------KPPK--------------------------- -------------------------------ESQMPE----------------------- ----------------------TVLSDTGSVTALHLGLEKEASTPLAFLNNEVEEAVSGH KDPVIGMLSDS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------CMKSACLEQSREEE--------------------MSKSIDSTVPVCQE-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------WGGDEHVDTKNDA------- -------------------------------------------------------VVPTT PQAEERDQCVTYSS---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------CLTH GRL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP AQGDP-KD------------------------------------------------RQ-V KNCVH------------------------------------------------------S ESPGVGRTPTANHGG---------------------------------SL--------GE SHVV------------------------------MEDSG---CSTCASEDGTS--VE--D P-LQNTM----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV TSGQHSDLLSTSAT----------QDTSAEQSSVPSEK-PSTPKLPEDSKVPYSNGMLKE DSPDLRHESNW------------------------------------------------- --------------MTETDGDHSG----GSDVNSMDSVDSG-CALGKTETRQ-NSKPAGE SSKSELTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQDFQICHIEGS QHHVDKALSLIGKKFKELSLTNIYAPPPPS-LT---LHSLPMTSW--------------- LMLPDGVTVEVIVANQVNAGHMFVQQHTHPTFHVLRSLDQQMYVCYSQPGIPTLPTPVEV GVICAAPGLDG-AWWRAQVVGYFKESSEVEIRYVDYGGYERVKIDTLRQIRSDFVTLPFQ GAEVLLDNVVPLP------------------------DEDHFSSEADTAVSEMTRGAALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSATGLPLIQLWSMMGDEV------------------------------ -----------------------------VSINRALVERGFA-QWIDSY----------- ------------------------------------------------------------ - >ENSARWP00000008727 ------------------------------------------------------------ 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------------------------------------------------------------ ----------CMKSACLEQSREEE--------------------MSKSIDSTAPVCQE-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EDAQPKGDELE---------------------------------------------- ------------------------------------------------------------ -------------------RE----KIGGV-----------------------------S LDK---------------------------------------------EEV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LSGSVSDVSS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RICQAAASR---------------------------------------- --------------------------------------AER------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------LERASTAASDQMLAVEP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------WGGDEHVDTKNDA------- -------------------------------------------------------VVPTT PQAEERDQCVTYSS---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------CLTH GRL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP AQGDP-KD------------------------------------------------RQ-V KNCVH------------------------------------------------------S ESPGVGRTPTANHGG---------------------------------SL--------GE SHVV------------------------------MEDSG---CSTCASEDGTS--VE--D P-LQNTM----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV TSGQHSDLLSTSAT----------QDTSAEQSSVPSEK-PSTPKLPEDSKVPYSNGMLKE DSPDLRHESNW------------------------------------------------- --------------MTETDGDHSG----GSDVNSMDSVDSG-CALGKTETRQ-NSKPGGE SSKSELTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQDFQICHIEGS QHHVDKALSLIGKKFKELSLTNIYAPPPPS-LT---LHSLPMTSW--------------- LMLPDGVTVEVIVANQVNAGHMFVQQHTHPTFHVLRSLDQQMYVCYSQPGIPTLPTPVEV GVICAAPGLDG-AWWRAQVVGYFKESSEVEIRYVDYGGYERVKIDTLRQIRSDFVTLPFQ GAEVLLDNVVPLP------------------------DEDHFSSEADTAVSEMTRGAALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSATGLPLIQLWSMMGDEV------------------------------ -----------------------------VSINRALVERGFA-QWIDSY----------- ------------------------------------------------------------ - >ENSDNVP00000020856 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRTFLPYALPGVLALL-GWWWFFSRKKEHGNNHDR-Q---------AIAI AEEQQIELPVNGSSSQTEEHAPQG------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LPLS-----------------------------SEEER-------- ------------------------------------------------------------ ----------------------------------------------------------PE NETSXSVLSAGSTT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SLLHQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------THE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------RLDFSQDL- ------------------------------------------------------------ ---------PAPAIMTIQ----------------------------PS-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------HE-DDSEK -----------------------------------------LERIDSQDESSIPACISL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LVSKSAKCHSSAVISPEQDS------ ------SSXATE---------------------------------------------G-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QWPSA---------------SVTLTQE S----------------------------------------------------------- -SGIMEEVSNVEQSNDSSC----------KPPK--------------------------- -------------------------------ESQMPE----------------------- ----------------------TVLSDTGSVTALHLGLEKEASTPLAFLNNEVEEAVSGH KDSVVGMLSDS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------CMKSARLEQSREEE--------------------MSQSIDSTVPTCQG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EDTQPEGDESE---------------------------------------------- ------------------------------------------------------------ -------------------RE----RIGGV-----------------------------S LDK---------------------------------------------EEV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LSGSVSDVSS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RICQAAASR---------------------------------------- --------------------------------------AET------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------PERAGTAASDQVLAVEP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RGGDEHVTTENDA------- -------------------------------------------------------VVPTS PQAEEHDQCVTYSS---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------CLTH GRL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP VQGDP-KD------------------------------------------------RQ-V KNCAH------------------------------------------------------S ESPGVGRTPVESHGG---------------------------------SL--------GE LHMV------------------------------MEDSG---CNTCASEDGTS--VE--D P-LQNTM----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV TSGQHSDLLSTSAT----------QDTSAEQSLVXSEK-PPTPKLPEDSKVPYSNGMLKE DSPDLRHESNW------------------------------------------------- --------------TTETDGDHSG----GSDVNSMDSVDSG-CALGQTETRQ-NLKPGGE SSKSELTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQDFQICHIEGS QHHVDKALSLIGKKFKELSLTNIYAPPPPS-LT---LHSLPMTSW--------------- LMLPDGVTVEVVVVNQVNAGHMFVQQHTHPTFHVLRSLDQQMYVCYSQPGIPTLPTPVEV GVICAAPGLDG-AWWRAQVVGYFKESSEVEIRYVDYGGYERVKIDTLRQIRSDFVTLPFQ GAEVLLDNVVPLP------------------------DEDHFSSEADAAVSEMTRGTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSATGLPLIQLWSMMGDEV------------------------------ -----------------------------VSINRALVERGFA-QWIDSY----------- ------------------------------------------------------------ - >ENSABRP00000020470 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRTLFPYAIPGVLALL-GCWWIYSNRKKHPSNHNR-Q---------VIAV AEEQQKELPENDSSPKTEARVSQR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LPLS-----------------------------SEEER-------- ------------------------------------------------------------ ----------------------------------------------------------PE NETSTSLPPAGSMT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SLLRQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------PHE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GLDFSRDL- ------------------------------------------------------------ ---------PAPAITTTQ----------------------------PS-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VK-DDSEK -----------------------------------------LEIIGSQDESSVPACVSL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LISKSSKCHSSAAVSPKQDS------ ------GSSSTQ---------------------------------------------D-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QWPSA---------------SVTLTQE S----------------------------------------------------------- -LGITEEISNAEQSDDSSF----------KPPK--------------------------- -------------------------------ESQMPE----------------------- ----------------------IVLSDAGCVTALHLGLEKEANIPQAFLNNEV-EVVSSH KDSVIRMLPDS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------SESACLEQSREEK--------------------MSELSDSTVPVCQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EGTQPKGDELE---------------------------------------------- ------------------------------------------------------------ -------------------RE----RIGGV-----------------------------S LDK---------------------------------------------EEV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LSGSVSDVSS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RICQAAASR---------------------------------------- --------------------------------------VER------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------LERASTVPSDQVLAAEAVG----- -----------------------GGENAA------AKSAVV------------------- ------------------------------------------------------------ ------LT---------------------------------------------------- --------------------------SP-----------QV------------------- ------------------------------------------------------------ ---EERNQCVTYSS---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------CLTH SCL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP VQGDT-KE------------------------------------------------CQ-V KNCVR------------------------------------------------------G ESQGVDRTPVASHGG---------------------------------SL--------GK SHLV------------------------------TEDSG---CSTCASDGATS--AE--D P-LQNTT----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV TSGQHSDLLSTSAT----------QDTSVEQSSVPSEK-PPTPKLPEDSKVPYSNGMLKE DGPDLRQESNW------------------------------------------------- --------------AAEIDGDHSG----GSDVNSMDSVDSG-CALGKTATRQ-NSKPGGE SSKSDLTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYSHDFQICHIEGS QHHVEKALSLIGKKFKELSLTNIYAPPPPS-LT---LHSLPMTSW--------------- LMLPDGVTVEVVVANQVNAGHMFLQQHTHPTFHVLRSLDQQMYVCYSQPGIPTLPTPVEV GIICAAPGLDG-AWWRAQVVGYFKESSEVEIRYVDYGGYERVKIDTLRQIRSDFVTLPFQ GAEVLLDNVVPLP------------------------DEDHFSSEADAAVSEMTRGAALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDNATGLPLIQLWSMMGDEV------------------------------ -----------------------------VSINRTLVERGFA-QWVDNY----------- ------------------------------------------------------------ - >ENSAPLP00000014357 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRTLFPYAIPGVLALL-GCWWIYSYRKKHPSNHNR-Q---------VVAI AEEQQKELPENDSSPKTEARVPQR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LPLS-----------------------------SEEER-------- ------------------------------------------------------------ ----------------------------------------------------------PE NEPSTSLLPAGSMT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SLLHQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------SHE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GLDFSRDL- ------------------------------------------------------------ ---------PAPAITTTQ----------------------------PS-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VK-DDSEK -----------------------------------------LEILGSQDESSVPACVSL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LVSKSSKCHSSAAVSPEQDS------ ------GSSSNQ---------------------------------------------D-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QQPSA---------------SVTLTQE S----------------------------------------------------------- -LGTTEEISNAEQSDDSSF----------KPPK--------------------------- -------------------------------ESQMPE----------------------- ----------------------IVLSDAGRVTALHLGLEEEANTPQAFLNNEV-EVVSGH QDSAIRMLPDS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------SESACLEQSREEK--------------------MSELSGSTVPVCQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EDTQPKGDELE---------------------------------------------- ------------------------------------------------------------ -------------------RE----RIGGV-----------------------------S LDK---------------------------------------------EEV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LSGSVSDVSS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RICQAAASR---------------------------------------- --------------------------------------VER------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------LERASTVPSDQVLAAEAVG----- -----------------------GGE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SA--------------------------------------------- --AAKSAAVLTATQVE---------------------------------ECDQHVTCS-- -------------------------------------------------------RCLTR SCL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP VQGDM-KE------------------------------------------------CQ-V KDCVH------------------------------------------------------G ESQGVDRTPVASHGG---------------------------------SL--------GK SHLV------------------------------MEDSG---CSMCASDGATS--AE--D P-LQNTT----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV TSGQHSDLLSTSAA----------QDTSVEQSSVPSEK-PPTPKLPEDSKVPYSNGMLKE DGPDPRQDSNW------------------------------------------------- --------------TAEIDGDHSG----GSDVNSMDSVDSG-CALGKTATRQ-NSKPGGE SSKSDLTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYSHDFQICHIEGS QHDVEKALSLIGKKFKELSLTNIYAPPPPS-LT---LHSLPMTSW--------------- LMLPDGVTVEVVVANQVNAGHMFLQQHTHPTFHVLRSLDQQMYVCYSQPGIPTLPTPVEV GIICAAPGLDG-AWWRAQVVGYIKESSEVEIRYVDYGGYDRVKIDTLRQIRSDFVTLPFQ GAEVLLDNVVPLP------------------------DEDHFSSEADAAVSEMTRGAALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDNATGLPLIQLWSMMGDEV------------------------------ -----------------------------VSINRTLVERGFA-QWVDNY----------- ------------------------------------------------------------ - >ENSCJPP00005023541 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRTFIPYAIPGVLALL-GCWWIYSHRKKHPSNHKR-K---------AIAI VEEKQKELPENDSPPKTEACVPQR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LPLS-----------------------------PEEER-------- ------------------------------------------------------------ ----------------------------------------------------------PE NETSTSLLPAGPMT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SLTRQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------TRE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------RLDFSRDL- ------------------------------------------------------------ ---------SAPAIRTTQ----------------------------PS-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------IE-DDSEK -----------------------------------------LEIKDSQDENSVPACVSL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LISKSAKCHSGAAVSPEEDS------ ------GSSANQ---------------------------------------------A-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KCPSA---------------SVVLTQG P----------------------------------------------------------- -FGIAEEISNAEQSDESSF----------KSPK--------------------------- -------------------------------ESQMPE----------------------- ----------------------IALSDTGCVTALHLGLEKEANTPQALLTN---EVVLSH QDSAVRMLPDS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------LQSACLEQCREEK--------------------ISESNDSTVPVCHG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EDTHAKGNELE---------------------------------------------- ------------------------------------------------------------ -------------------RG----RIRGV-----------------------------S LDK---------------------------------------------EEV--------- ------------------------------------------------------------ EKIEQVAIQIISNVILAATEEV-------------------------------------- --------------------------LSGSVSDVSS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RICQAAASR---------------------------------------- --------------------------------------VER------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------QERASTVSSDELLVAEA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GGGDKNTALKSDA------- -------------------------------------------------------AVPTS LPTEECDQCVTYSS---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------CSAL GHL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP VQRDA-QD------------------------------------------------HQ-E KNCVS------------------------------------------------------S ESQGGDRTLVASHGE---------------------------------SL--------GK SHLT------------------------------VEDSG---FSTCASEGGTS--VE--D L-LQNTM----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV ASGQHSDSLSTSAT----------QDTSAEQSSEAGEK--PTTKLPEDSKVPYSNGMLKE DGSESRHESNW------------------------------------------------- --------------VAETDGDHSG----GSDVNSMDSVDSG-CALGKTETHQ-NSKPGGE SSKSDLTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYSHDFQICHIEGS QHHVEKALSLIGKKFKELSLTNVYAPPPPS-LA---LHSLPITSW--------------- LMLPDGVTVEVVVANQVNAGHMFLQQHTHPTFHVLRSLDQQMYVCYSQPGIPTLPTPVEV GIICAAPGLDG-AWWRAQVVGYFKDSGEVEIRYVDYGGYERVKIDTLRQIRSDFVTLPFQ GAEVLLDNVVPLP------------------------DEDHFSSEADAAVSEMTRGAALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSATGLPLIQLWSMMGDEV------------------------------ -----------------------------VSINRTLVERGFA-QWVDNY----------- ------------------------------------------------------------ - >ENSMGAP00000008497 VNLKQ------------------------------LESS--------------------- --------------PD-------------------------------------------- -------------------------------------------------------VLT-- --------------------------------ENSSR----------------------- ------MALRFRTFFPYAIPGVLALL-GCWWIYSHRKKHPSNRNR-Q---------AIAI VEEKQKELPENDSPPKTEACVPQR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LPLS-----------------------------PEEER-------- ------------------------------------------------------------ ----------------------------------------------------------PE NETSTSLLPAGPMT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SLTRQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------TRE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------RLDFSRDL- ------------------------------------------------------------ ---------SAPAIRTTQ----------------------------PS-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------IE-DDSEK -----------------------------------------LEIKCSQDESSVPACVSL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LISKSAKCRSGAAVSPEEDS------ ------GSSANQ---------------------------------------------A-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KCPSA---------------PVVLTQG S----------------------------------------------------------- -LGITEEISNAEQSDESSF----------KPPK--------------------------- -------------------------------ESQMPE----------------------- ----------------------IALSDTGCVTALHLGLEKEADTPQALLIN---EVVLSH QDSAVRMLSDS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------LESACLEQSREEK--------------------IPESNESTVPVCQG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EDTHAKGNELE---------------------------------------------- ------------------------------------------------------------ -------------------RE----RIRGV-----------------------------S LDK---------------------------------------------EEV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LSGSVSDVSS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RICQAAASQ---------------------------------------- --------------------------------------VER------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------QERASTVSSDQLLAAEA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GGVDENTALKSDA------- -------------------------------------------------------AIPTS LPTEEHDQCVTYSS---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------CLAL GHL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP VQGDT-QD-------------------------------------------------Q-E KNCVH------------------------------------------------------S ESQRVDRTLVASHGG---------------------------------SL--------GK SCLV------------------------------MEDSG---CSTCASEGGTS--VE--D P-LQNAM----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV ASGQHSDLLSSSAT----------QDPSAEQSSEPSEK-PPALKLPEDSKVPYSNGTLKE DGSDSRHEGNW------------------------------------------------- --------------AAEMDGDHSG----GSDVNSMDSVDSG-CALGKTETRQ-NSKPGGE SSKSDLTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYSHDFQICHIEGS QHHVEKALSLIGKKFKELSLTNIYAPPPPS-LA---LHSLPMTSW--------------- LMLPDGVTVEVVVANQVNAGHMFLQQHTHPTFHVLRSLDQQMYVCYSQPGIPTLPTPVEV GIICAAPGLDG-AWWRAQVVGYFKESGEVEIRYVDYGGYERVKIDTLRQIRSDFVTLPFQ GAEVLLDNVVPLP------------------------DEDHFSSEADAAVSEMTRGAALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSATGLPLIQLWSMMGDEV------------------------------ -----------------------------VSINRTLVERGFA-QWVDNY----------- ------------------------------------------------------------ - >ENSGALP00000008930 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRTFFPYAIPGVLALL-GCWWIYSHRKKHPSNRNR-Q---------AIAI AEGKQKELPENDSPPKTEACVPQR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LPLY-----------------------------PEEER-------- ------------------------------------------------------------ ----------------------------------------------------------PE NETSASLLPAGPMT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SPTRR----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------TRE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------RLDFSRDL- ------------------------------------------------------------ ---------SAPAIRTTQ----------------------------PS-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VE-DDSEK -----------------------------------------LEIKGSQDESSVPACVSL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------S- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LISKSTKCRSGAAVSPEEDS------ ------GSSTNQ---------------------------------------------A-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KCPSA---------------SVVPTQR S----------------------------------------------------------- -LGITEEISNAEQSDESSL----------KPPK--------------------------- -------------------------------ESQMPE----------------------- ----------------------IALSDTGCMTALHLGLEKEADAPQALLTN---EVVLSH QDSAVRVLSGS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------LESACLEQSREEK--------------------IPESNDSTVPVCQG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EDAHAKGNELE---------------------------------------------- ------------------------------------------------------------ -------------------RE----RIRGV-----------------------------S LDK---------------------------------------------EEV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LAGSVSDVSS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RICQAAASR---------------------------------------- --------------------------------------VER------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------QERASTAASDQLLAAEA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GGGDKNTALKSDA------- -------------------------------------------------------AVPTS LPTEERDQCVTYSS---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------CSAL GHL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP VQGDT-QD------------------------------------------------HQ-E KNCVH------------------------------------------------------S ESQGVDRTLVASHGG---------------------------------SL--------GK SHLV------------------------------MEDSG---CSTCASEGGTS--VE--D P-LQNTM----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV ASGQHSDLLSTSAT----------QDTSAEQSSEPSEK-PPTLKLPEDSKVPYSNGMLKE DGSDSRHEGNW------------------------------------------------- --------------AAEMDGDHSG----GSDVNSMDSVDSG-CALGKTETHQ-NSKPGGE SSKSDLTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYSHDFQICHIEGS QHHVEKALSLIGKKFKELSLTNIYAPPPPS-LA---LHSLPMTSW--------------- LMLPDGVTVEVVVANQVNAGHMFLQQHTHPTFHVLRSLDQQMYVCYSQPGIPTLPTPVEV GIICAAPGLEG-AWWRAQVVGYFKDSGEVEIRYVDYGGYERVKIDTLRQIRSDFVTLPFQ GAEVLLDNVVPLP------------------------DEDHFSSEADAAVSEMTRGAALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDNATGLPLIQLWSMMGDEV------------------------------ -----------------------------VSINRTLVERGFA-QWVDNY----------- ------------------------------------------------------------ - >ENSNMEP00000012403 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRTFFPYAIPGVLALL-GCWWIYSHRKKHPSNRNR-Q---------AIAI VEEKQKELPENDSPPKTEARVPQR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LPLS-----------------------------PEEER-------- ------------------------------------------------------------ ----------------------------------------------------------PE NETSTSLLPAGSMT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SLMRQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------THE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------RLDFSRDL- ------------------------------------------------------------ ---------SAPAIRTTQ----------------------------PR-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VE-DDSEK -----------------------------------------LEIKGSRDESNVPACVSL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LISKSAKCHSGAAVSPKEDS------ ------GSSANQ---------------------------------------------A-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KCPSA---------------SVVLTQG S----------------------------------------------------------- -LGIMEEISNAEQSDESSF----------KPPK--------------------------- -------------------------------ESQVPE----------------------- ----------------------IALSDAGCVTALHLGLEKEVNTPQALLTN---EVVLSH QDSAVRMLSDS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------LESACLEQSREEK--------------------MSESNNSSVPVCQE-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EDTHAKGNELE---------------------------------------------- ------------------------------------------------------------ -------------------RE----RIRGV-----------------------------S LDK---------------------------------------------EEV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LSGSVSDVSS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RICQAAVSR---------------------------------------- --------------------------------------VER------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------LERASTVSSDQVLAAEA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GGEDKNTDLKSDA------- -------------------------------------------------------EVPTS LQTEERDQCVTYSS---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------CLAL GCL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSP IQGDV-QD------------------------------------------------HQ-V KNCVH------------------------------------------------------S ESQGVDRTLVASHGG---------------------------------SL--------GK SHLV------------------------------TEDSG---CSTCASEGGTS--VE--D P-LQNTM----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV ASGQYSDLLSTSAT----------QDTSAEQSSEPSEK-PPTPKLPEDSKVPYSNGMLKE EGSDSRHEGNW------------------------------------------------- --------------AAEMDGDHSG----GSDVNSMDSVDSG-CALGKTETHQ-NSKPGGE SSKSDLTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYSHDFQICHIEGS QHHVEKALSLIGKKFKELSLTNIYAPPPPS-LA---LHSLPMTSW--------------- LMLPDGVTVEVVVANQVNAGHMFLQQHTHPTFHVLRSLDQQMYVCYSQPGIPTLPTPVEV GIICAAPGLDG-AWWRAQVVGYFKDSGEVEIRYVDYGGYERVKIDTLRQIRSDFVTLPFQ GAEVLLDNVVPLP------------------------DEDHFSSEADAAVSEMTRGAALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSATGLPLIQLWSMMGDEV------------------------------ -----------------------------VSINRTLVERGFA-QWVDNY----------- ------------------------------------------------------------ - >ENSCPGP00000023207 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALCFRSFTLYAIPGVLALV-GCWWIYSHRKKHAGYHDK-Q---------APAT EEEQQEEVPENDSAPKTEVCVPRR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LPLS-----------------------------SEEEC-------- ------------------------------------------------------------ ----------------------------------------------------------PE NKASTSLLPAGPTT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SLLCQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------AQE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------RPDLSQDL- ------------------------------------------------------------ ---------PDLSVTTAQ----------------------------PS-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LE-DDSEK -----------------------------------------LETIGSQDESGVPACVPL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LVSRSP-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------TQG SS-------------SSA-----------------------------NQDQQRPAVMTQE PLGITEEISHAEQSDDSSF----------KPPK--------------------------- -------------------------------ESQMPE----------------------- ----------------------IVPSDAGPVTALCLGLEKEANTPQAPLNNGV-EVVSSH KDSVASVLPDS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------LESACVERSREEE--------------------MPESIASTVPVCQE-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EDIWLKGHELE---------------------------------------------- ------------------------------------------------------------ -------------------RE----KTEGM-----------------------------S LDK---------------------------------------------EEV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LSGSASDVSS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------WICQTAASR---------------------------------------- --------------------------------------AER------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------LETASIVSSDGMPAEEA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------TGADENVAAESNA------- -------------------------------------------------------AGLTS LHTEEQHQCVTGSS---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------CLTH NCL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SAP VQGDT-KD------------------------------------------------CQ-K KNRVC------------------------------------------------------S QSQGADRTPVENHGE---------------------------------SL--------ER SSLV------------------------------MEDSG---CSTYASEGGTS--VE--D P-LQNTM----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV SSGQHSDSLSISAT----------QDTSAEQSSVPSEK-PPTPKLPENSVVPYSNGILKE DSPDLPHECGR------------------------------------------------- --------------AAGVDGEHSG----GSDVSNMDFVDSG-CALRKTVTRQ-NSKLGGE SSKSDFVIWEIEVP-KELVGRLIGKQGRFMSFLRQASGAKIYVSTLPYFHDSQVCHIEGS SHQVEKVLSLIGKKFKELCLTNIYALPPPTPLT---LHSLLMTAW--------------- LFLPDGVTVEVVVANQVDAGHMFLQQHTHPTFHVLRSLDQQMYACYSQPEIPTLPTPVEV GIICAAPGLDG-AWLRAQVVSYFEETNEVELRYVDYGGYDKVKVDTLRQIRSDFLSLPFQ GAEVLLDNVVPLP------------------------DEDHFSSEADAAVSEMTRGAVLV A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSVTGLPLIQLWNLMGDEV------------------------------ -----------------------------LSINRTLVERGFA-QWLD-Y----------- ------------------------------------------------------------ - >ENSCPUP00000017240 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALCFRSFTLYAIPGVLALV-GCWWIYSHRKKHAGYHDK-Q---------APAT EEEQQEEVPANESAPKTEACVPRR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LPLS-----------------------------SEEEC-------- ------------------------------------------------------------ ----------------------------------------------------------PQ NKAATSLLPAGPTT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SLLCQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------AQE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------RPDLSQDL- ------------------------------------------------------------ ---------PDLSVTTAQ----------------------------PS-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LE-DDSEK -----------------------------------------LETIGSQDESGVPACVPL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LVSRSP-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------TQG SS-------------SSA-----------------------------NQDQRRPAATRQE PLGITEEISHAEQSDDSSF----------KPPK--------------------------- -------------------------------ESQMPE----------------------- ----------------------IVPSDAGPVTALCLGLEKEANTPQASLNNGV-EVVLSH KDSAASVLPDS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------LESACVERSREEE--------------------KPESIASTVPVCQE-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EDIQLKGHELE---------------------------------------------- ------------------------------------------------------------ -------------------RE----KTEGM-----------------------------S LDK---------------------------------------------EEV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LSGSASDVSS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------WICQTAASR---------------------------------------- --------------------------------------AER------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------LETASVVSSDGMPVEEA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MGADENVAAESDA------- -------------------------------------------------------AGPTS LQTEEQHQCVTGSG---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------CLTH NCL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SAP VQGDT-KD------------------------------------------------CQ-K KNRVC------------------------------------------------------S QSQGADRTPVEKHGE---------------------------------SL--------ER SSLV------------------------------MEDSG---CSTYTSEGGTS--VE--D P-LQNTM----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSV SSGQHSDSLSISAT----------QDTSAEQSSVPSEK-LPTPKLPEDSVVPYSNGILKE DGPDLSQECSR------------------------------------------------- --------------AAGVDGEHSG----GSDVSNMDFVDSG-CALRKTVTRQ-NSKLGGE SSKSDFVIWEIEVP-KELVGRLIGKQGRFMSFLRQASGAKIYVSTLPYFHDSQVCHIEGS SHQVEKVLSLIGKKFKELCLTNIYALPPPTPLT---LHSLLMTAW--------------- LFLPDGVTVEVVVANQVDAGHMFLQQHTHPTFHVLRSLDQQMYACYSQPEIPTLPTPVEV GIICAAPGLDG-AWLRAQVVSYFEETNEVELRYVDYGGYDKVKVDTLRQIRSDFLSLPFQ GAEVLLDNVVPLP------------------------DEDHFSSEADAAVSEMTRGAVLV A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSVTGLPLIQLWNLMGDEV------------------------------ -----------------------------LSINRTLVERGFA-QWLD-Y----------- ------------------------------------------------------------ - >ENSCPBP00000013467 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRTFFPYALPGVLALI-GWWWFFSRKKERTSNHDR-Q---------ALAG VEDQ-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RI---------------EPP IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LSREEVN------------------- ----------ATKELPVP-----------------------------SEEDC-------- ------------------------------------------------------------ ----------------------------------------------------------PE NETLTSQLSVGLMT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SLACD----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------AQQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------RLDSSRDH- ------------------------------------------------------------ ---------PATAVTTVE----------------------------LG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------FE-DDSEK -----------------------------------------LERAASRDETGSLAQVSP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PS APKS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VECSDNGVLVTR--------------QESV--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------FSGIPAQQP------------------------ -----------------LACSVVESLQESLGKTGESGEAEKTHNSLEN------------ ------------------------------PSK--------------------------- -------------------------------EIQCLAATSSDTGCLPALGSEPEDSATAQ PAILAEDDSKEVEGTVPRQ----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------R------ ESVVGKLLNNCVESAGLDLSREEE--------------------MSEMTVSTVLKCHGRE ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E KCYRDTQSKEDSLE---------------------------------------------- ------------------------------------------------------------ -------------------RE----RIGGV-----------------------------S LDK---------------------------------------------EEV--------- ------------------------------------------------------------ EKIEQAAIQIISKVILAATEEV-------------------------------------- --------------------------LSSSVSDVSS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RICEVAVSR---------------------------------------- --------------------------------------VDR------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------LERVSI-SSDEMLAVES------- ----------------------------------------SRGNEAVSTENVATIPVSL- ------------------------------------------------------------ --SEEKL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------HRYVSYSS---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------CLKY GRL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SNP VQIDP-KD------------------------------------------------HR-P KKSVH------------------------------------------------------T ETQGDNRTLITNNGE---------------------------------SF--------EE SHAV------------------------------TEDSG---CSACTSEDGTN--VE--D P-LQSTS----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSL LSGQRSDLLSMSVI----------QDASTEQNVAQSEK-PQTPILGE-DKVPYSNGVLKG DSADLRHEKHW------------------------------------------------- --------------TAETDADHSG----GSDVNSMDSVDSG-CALGKTESCQ-NSKPGVE SNKSELTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQDVQICHIEGS QHHVDKALSLIGKKFKELSLTNIYAPPAPS-LM---LHSLPMTSW--------------- LMLPDGVTVEVIVVNQIDAGHMFVQQHTHPTFHVLRSLDQQMYVCYSQPGIPTLPTPVEV GVICAAPGLDG-AWWRAQVVDYFKDNNEVEIRYVDYGGYERVKIDTLRQIRSDFVTLPFQ GAEVLLDNVVPLS------------------------DEDHFSSEADSSVSEMTRGTPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSATGLPLIQLWSMMGDEV------------------------------ -----------------------------VSINRALVERGFA-QWIDSY----------- ------------------------------------------------------------ - >ENSGAGP00000022541 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRTFFPYALPGVLALI-GWWWFFSRKKERTSNHDR-Q---------ALSG VEDQ-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RI---------------EPP IKEP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LSRAEVN------------------- ----------ATKELPVP-----------------------------SEEDC-------- ------------------------------------------------------------ ----------------------------------------------------------PE NETLTSQLSVGLMT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SLACD----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------AQQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------RLDSSRNH- ------------------------------------------------------------ ---------PATTVTTVK----------------------------LG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------FE-DDSEK -----------------------------------------LERAASRDETGSLAQVSP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PS APKS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------IECGDNGVLVTK--------------QESA--- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------FSGIPEQQP------------------------ -----------------LVCSVVESVQESLGKTGESGEAEMTHDSLEN------------ ------------------------------PSK--------------------------- -------------------------------EIQCPAATSSD------LGSEPEDSATAQ PAILDDDDSKEVKDIVPGQ----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------R------ ESVVGKLLNNSVESAGLDLSREEE--------------------MSEMTVSTVLKCHGRE ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E KCYRDVQSKGECLE---------------------------------------------- ------------------------------------------------------------ -------------------RE----RIGGV-----------------------------S LDK---------------------------------------------DEV--------- ------------------------------------------------------------ EKIEQAAIQIISKVILAATEEV-------------------------------------- --------------------------LSSSVSDVSS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RICEVAVSR---------------------------------------- --------------------------------------VDR------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------LERVSI-SSDEMLAVES------- ----------------------------------------SGGKEAVSTESVATIPVPL- ------------------------------------------------------------ --SEEKL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------HRYVSYSS---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------CLKY GRL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SNP VQVDP-KD------------------------------------------------RR-P KKSVH------------------------------------------------------S ETQGDNRTLVTNNGE---------------------------------SF--------KE SHAV------------------------------MEDSG---CSASTSEDGMN--VE--D P-LQSTS----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSL LSSQHSDLLSMSVI----------QDASTEQNMAQSAK-PQTPILGE-DKVPYSNGVLRG DSADLRHETHW------------------------------------------------- --------------TAETDADHSG----GSDVNSMDSVDSG-CALGKTESCQ-NSKPGVE SNKSELTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQDVQICHIEGS QHHVDKALSLIGKKFKELSLTNIYAPPAPS-LM---LHSLPMTSW--------------- LMLPDGVTVEVIVVNQIDAGHMFVQQHTHPTFHVLRSLDQQMYVCYSQPGIPTLPTPVEV GVICAAPGLDG-AWWRAQVVDYFKDNNEVEIRYVDYGGYERVKIDTLRQIRSDFVTLPFQ GAEVLLDNVVPLS------------------------DEDHFSSEADSSVSEMTRGTPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSATGLPLIQLWSMMGDEV------------------------------ -----------------------------VSINRALVERGFA-QWIDSY----------- ------------------------------------------------------------ - >ENSPSIP00000008455 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRTFFPYALPGVLALI-GWWWFFSRKKERASNHDR-Q---------TLAG VEDQ-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RF---------------EPP IKKP-------------------------------------------------------- ------------------------------------------------------------ ----------------------------------LSREEAN------------------- ----------ANQDLPVT-----------------------------SEEDC-------- ------------------------------------------------------------ ----------------------------------------------------------PE NETVTSQLSVGLMT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ --------------------------------------SLAWE----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------APP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------RLVPSRDL- ------------------------------------------------------------ ---------PATAVTTVE----------------------------SG-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------FEDDDSEK -----------------------------------------LEGAASEDETGSLAQVSP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP APKSEGCCDNSVVGA---------------------KPESTFSGIP-------------- -------DQQLLSSVVESE----------------------------------------- -------------RES-------------------------------------------- ------------------------------------------------------------ ----------------------------------L------------------------- ---------------------------------------------------------GK- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------TRENSAV-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EMTHDSSEN------------ ------------------------------PSR--------------------------- -------------------------------EIQCPEATSSETDCLPALGSGPENSATAQ PTVLDEDDSEDVEGTVPGQGELIV------------------------------------ ----------EKSP---------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------S------- ---------NCVESACSDLSGEEE--------------------ISEMTISTVLKCQGRE ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E KCYRDTQAKGDSLE---------------------------------------------- ------------------------------------------------------------ -------------------RE----RIEGV-----------------------------S LDK---------------------------------------------NEV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATEEV-------------------------------------- --------------------------LSNSVSEVSG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RLCQVTASR---------------------------------------- --------------------------------------VET------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------LDRVSI-SSNEMLVVES------- ----------------------------------------SQGNKTVPTENVAVMP---- ------------------------------------------------------------ ---EEKL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------NRYASYSS---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------CLKY GRL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SNP VPGDP-KD------------------------------------------------RR-P QKSAQ------------------------------------------------------S ESQGDNRTLVTNHGE---------------------------------AL--------EE SHVA------------------------------TEDSG---CSACTSEDGTS--VE--D P-LQSTS----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSR LSSQRSDLLSTSGI----------QDASMEQDMAQSEE-LQTPILGD-EEVPYSNGMLKG DSADLRHEKPW------------------------------------------------- --------------TAETDADHSG----GSDVNSMDSVDSG-CALGKTESCL-NSKPGGE SHKSELTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQDVQICHIEGS QHHVDKALSLIGKKFKELSLTNIYAPPAPS-LM---LHSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHMFVQQHTHPTFHVLRSLDQQMFVCYSQPGIPTLPTPVEV GVICAAPGLDG-AWWRAQVVGYFKENSEVEIRYVDYGGYERVKIDTLRQIRSDFVTLPFQ GAEVLLDNVVPLP------------------------DEDHFSSEADTSVSEMTRGTPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDGATGLPLIQLWSMMGDEV------------------------------ -----------------------------VSINRALVERGFA-QWIDSY----------- ------------------------------------------------------------ - >ENSCPRP00005014203 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRRFLPYALPGVLALI-GWWWFFSRKKERESNHDR-Q---------VLVG VQEQ-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RI---------------EPP KKEPSSGEEPNVLRVLPVLVAEGRPENETFPPKPSLGSVT-----------------PP- ------------------------------------------------------------ -------------------------LSLRTLEGS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DSSENL- ------------------------------------------------------------ ---------PATVMTAVE----------------------------LD-T---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LD-DDSDK -----------------------------------------LERAVSREESGSPAQVSP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LVLESVES------------------ ------TSSATL---------------------------------------------G-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QQP------------------------ -----------------LVCPALESAQEPFGKTGRLGEVETTRDALKR------------ ------------------------------PPR--------------------------- -------------------------------ETQCPETTSVD------------------ ------------------------------------------------------------ -------------PSLSPAPC--------------------------------------- --PEP--------------------------------GKEADTQPIASDEEDQKEVGEVD SKQRESEVGMFPNSCVESVCSEPSGKEMSESTDQHA---------------LC------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----TQSKGDGLQ---------------------------------------------- ------------------------------------------------------------ -------------------KE----RTGGV-----------------------------S LDK---------------------------------------------DEV--------- ------------------------------------------------------------ EKIEQVAIQIISKVILAATGEV-------------------------------------- --------------------------LSGSVSDVSS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RLCQ--------------------------------------------- --------------------------------------ADR------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------QERVS------------------- ---------------------------------------------------------TLL SDPTPAAEPSRESKAAAAQSATAIPAPG-------------------------------- --AEEKL----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------DSCTTYSS---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------YLKH GCL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SHP VQ---------------------------------------------------------- ------------------------------------------------------------ -------------GETSKDPQPKRSAHGEV-----PGACRTLVAKCQASL--------EE SPPA------------------------------MEDSG---CSACTSEDGMS--ME--D P-LQSTS----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSL LAGQHTDSLSTSAI----------QDTSIEQSLVPSEK-PVTPKLPEDDKVPYSNGMLKE DSPDLRHERNW------------------------------------------------- --------------ATETDADHSG----GSDVNSMDSVDSG-CALGKTETRQ-NSKPGVD SNKSELTIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQDFQICHIEGS QHHVDKALSLIGKKFKELNLSNIYAPPPPS-LA---LHSLPMTSW--------------- LMLPDGVTVEVVVVNQVNAGHMFVQQHTHPTFHVLRSLDQQMYVCYSQPGIPTLPTPVEV GVICAAPGMDG-AWWRAQVVGYFKDSSEVEIRYVDYGGYERVKIDTLRQIRSDFVTLPFQ GAEVLLDNVVPLP------------------------DEDHFSSEADAAVGEMTRGMALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSATGLPLIQLWSMMGDEV------------------------------ -----------------------------VSINRALVERGFA-QWIDSY----------- ------------------------------------------------------------ - >ENSSMRP00000016986 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRTLLPFAIPGVLALI-GWWWFSSRKRERVS-HDR-R---------GLAG LEGK--------------------------DGARSAEDNLLPDTLSSPLETKPLARPTST AAASSAEPRARAQGLSSSKDPAVVTETTGSRPSVLRGDGQKLEAGERRGVFGPQTCNFFL PRPHVANDVGGEETPMEGKLDPSRVGHQVSQMPPATAVLPEALHLEKSEEMSKGTEVQST LSEETLQKE--------------------------SSLAAG------------------- --------SLEEAAQPTSPSAVPDGAVSEGPPSATKTGKSSSAIAGELETVAEVVTKHVQ SASSEFSPGEEPSGPTANHISKRHGC---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GEVGYRGG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AE---------------------------------------------- ------------------------------------------------------------ -------------------AE----QLGGI-----------------------------S LDK---------------------------------------------GEV--------- ------------------------------------------------------------ EKIEQVALHIISNVIRAATEEV-------------------------------------- --------------------------LSGSAGDVSD------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RICQI-AGR---------------------------------------- --------------------------------------VSK------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------PEK--------------------- ------------------------------------------------------------ -------------------------PPS----GASGQAESIMGTECSAKKAVEVTP---- -LLEENVH---------------------------------------------------- -----------------------RHTM--------------------------------- ------------------------------------------------------------ -----------YSS---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------HLTH GVL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------VRP GHGRP-RDSPGQLAGTLPEAS--------------------------------------- ------------------------------------------------------------ -----------NHDE---------------------------------EF--------ED AQTV------------------------------TEDSG---CSACTSEDGVS--AE--D L-LKSTS----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LPA LE-QHSDLLDAPAI----------KDS--QHKLAFGRK-PPSPPLGE-PKLPYSNGLLKE ECPHLRHEQSW------------------------------------------------- --------------QTEADGDNSG----GSDVNSMDSVDIG-C-VRKNDSFQ-KSKLGAD SKNTELVIWEIEVP-KHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQDFQICHIEGS QQNVDKALTLIGKKFKDLSLTNIYAPPPPP-LP---LHSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHLFVQQHTHPTFHVLRSLDQQMYLCYSQPGIPTMPTPVEV GVVCAAPGVEG-AWWRAQVVAYFRDADEVEIRYVDYGGYERVKIETLRQIRSDFVTLPFQ GAEVLLDNVVPLP------------------------DDDHFSTEADTAVGEMTRGTPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSATGLPLIQLWSMIGDEL------------------------------ -----------------------------VSINRTLVERGFA-QWIESY----------- ------------------------------------------------------------ - >ENSPVIP00000029234 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRFRTLLPFAIPGVLALI-GWWWFSSRKKERVSNHDR-R---------DPAG LE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EC--------------RI---------------GSP EDFPSNSE-------------------LSLPPEAK------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------LPV------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------ESAVA-- ----------------------LEPLLERQAPPPPPPEHREWSLGSSTREP--------- ----------------------------------------PA--------LAKPAVK--- ------------------------------------------------------------ ----------SDV---------------------------------------HQ-DDSEK -----------------------------------------LEVMGCQGAFGSPA----- --LQSSLPGAPGKAHSCAGEATVERKLDA----------SR----------VA------- ------------------EEALLTAA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------SLELP- ------------------------------------------------------------ --------------CVEKS----------------------------------------- -------------RE--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SREGRGVQ------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------NSPS----------------------- -----------------------ESL---------------------------------- --------------------------------K--------------------------- -------------------------------EGPCPMTTASS------------------ ------------------------------------------------------------ -------------PGCVPTRCSEVAHDAVAEGPMLANKEMNEFNGGVLGAVEPEVRGAAD QRPEPQSVDVAQETVTSSSNAGNMLLKHQGVGEAGCKGS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LE---------------------------------------------- ------------------------------------------------------------ -------------------KK----KLGGI-----------------------------S LDK---------------------------------------------EEV--------- ------------------------------------------------------------ EKIEQVAIHIISNVIRAATEEV-------------------------------------- --------------------------LSGSADCVSG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RMCQM-AGR---------------------------------------- --------------------------------------TDR------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------PEKASA------------GAVGQG ESGKENE---------------PGAEKVA------PAE---------------------- -----------------------LPPP--------------------------------- --VEENIS---------------------------------------------------- -----------------------RPAV--------------------------------- ------------------------------------------------------------ -----------FSS---------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------HLTH GLL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------ANP GHGQPTRD------------SVGHDR------------------------PVGDPAT--- ------------------------------------------------------------ ---------VTNHEE---------------------------------EL--------ED IHGV------------------------------TEDSG---CSACASEDGAS--AE--D L-LKSTS----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------SPP LQ-QRLDLLNMPAVTGLERHSASSK------------K-PPSPTLME-DKVPYSNGMLKE DGPPLGHEQAW------------------------------------------------- --------------PGEADTDHSG----GSDVNSMDSVDSG-CAVQKNGSCQ-KS--GLD SSKTELVIWEIEVP-KHLVGRLIGKQGRYVSFLKQVSGAKIYISTLPYTQDFQICHIEGS QQNVDKALSLIGKKFKDLSLTNIYAPPPPP-LP---LHSLPMTSW--------------- LMLPDGVTVEVIVVNQVNAGHLFVQQHTHPTFHVLRSLDQQMYLCYSQPGIPTMPTPVEV GVVCAAPGVEG-AWWRAQVVGYFKDTNEVEIRYVDYGGYERVKIDTLRQIRSDFVTLPFQ GAEVLLDNVVPLP------------------------DDDQFSSEADTVVSEMTRGTPLL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDSATGLPLIQLWSMIGDEL------------------------------ -----------------------------VSINRTLVERGFA-QWVESY----------- ------------------------------------------------------------ - >ENSXETP00000020784 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MALRMRLIFPYAVSGVLALI-GCWWLFSRKKDQRSKKHK-S---------ITAP SDKVQ------------------------------VDDE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------QKEFVLTQDIVSCLREQPVHLNRTDTPNASSLASEELGNFLIECSSLETIESEP MTENIVECSLNEIVDPS------------------------------------------- ------------------------ECYTTGNTKATKGTA--------------------- ------------------------------------GSV--------------------- ------------------------------------------------------------ -------------------------------------EDLCICSSDSTQ----------- -----TLLS-----LPIGTNVAVPHDDTSW----------------SSEETSNI------ ------------------------------------------------------------ --------------------------------------------------------LSPG ---------------EFVCESKLDTGSLKIAAVNEE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------IVS----- -----------------------LHEQTT-------------PTHLDALSCI-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TE----------------------K----IDKPTED ------------------------------------------------------------ ------------------------------------------------------------ ------------------KPLH-------------------------------------- --------------------------------------------------------VAPV TNES---EEQV------------------------------------------------- ------------------------ILL--------------------------------- ------------------------------------------------------------ ----------------------------------------------PG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QECSGLVELITTEVCSHPLDFPEITLT------DDS-- ------------------------------------------------------------ -NVQST------------DNESVEADIE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EVEA--VVQMSVSVPFSLSTNEGQIILGSVSGTQ----------- ------------------------------------------------------------ ----------------------------------------------EFQQQND-SL--P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DTNSI--- --------------------ELVKVI-------------------------------GGG --------TL---------------------EQKRMEA---------------------- --------------------LEQDKENKRNT----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------HGGD- ---------------------------------SEPV----------------------- -------------------------------------------------------VLKET ------------------------------EPQVLDL----------LPTT--------- --------------------------------------------CI-------------- ------------------------------------------------------ETVS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------A---------- ---------------------------------------------GT------------- ------------------------------------------------------------ ------------------------------------------------L----------- ------------------------------------------------------------ -------------------RE---DKCAAVISAYS-------------H----------C LEKAEKFVASGDVVADSLKGNAKQIFGDY--------------------DT--------- ------------------------------------------------------------ KMVEQLAINIISKVIVAAKQEI-------------------------------------- --------------------------LSGKVSDILE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------NSCQ----------------------------------------E---- ----------------------------------------------------QDTGIGE- ------------------------------------------------------------ SLLLETQSSEESQQVIQEQNGLACGLQSDSFTVNDLACESLQTEQKDAENINSCSVDIQD IC----------------------------------------------------P----- ------------------------------------------------------------ ------------------------------------------------------------ -----------EQQ---------------------------------------------- --SEE------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------VEYIE---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------KD--------LAHRT-----------------------------------KK-- ------------------------------------EPDFS------------------- ---------------------PV--------------------HKVVDSF--------DE VHEI------------------------------IDDSN---ISSCTSEDGIC--IE--E P-LQSTV----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------LSG VGVGSYDSLSTSGI----------ETTQEQLSMSSDQV-KKSSPVET-KNLPYSNGDLKR MSPDLKSDGQW------------------------------------------------- --------------IPDIEVDHSG----GSDVNSMDSVDSG-CAL-KTEQLQ-NVK-RAD AKKAELVIWEIEVP-KHLVGRLIGKQGRFVSFLKESSGAKIYISTLPYTQDFQICHIEGS RQQIDRALVLIGKKFKELNLTNIYAPP-PC-LA---LHSFPMTSW--------------- LMLPDGVTVEVIVVNVVNAGHMFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEA GVICAAPAEDN-AWWRAQVVAYFKDEEEVEIRYVDYGGYERVKVDTLRQIRSDFVTLPFQ GAEVLLDNVIPLA------------------------EEDHFSTEADEAATEMTRGTALL A-----------Q-V--------------------------------------------- ------------------------------------------------------------ --------TNYDGPTGLPLIQLWSMMADEV------------------------------ -----------------------------VSVNRTLVERGFA-QWMDSF----------- ------------------------------------------------------------ -