>ENSMZEP00005038204 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GK-------------GRFDAGA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGP---------ERGVAATAGPSDACEYGSGR-------- ------------------------------------------------------------ ------------------------------------------------------------ -------VNTGGFLDRTS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LAE LPPELLVEIFSLLPGTTLSNVALVCKKFRQLLKTETIW-------------------RRR CI---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMREDLRKVEAR-GVTSQDLYVK-------------------------------LL--- -----------------------------YPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFQIHMMESNKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAKPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGMSARATKLTGDPNVPAGQLTLDVNLCRPVVLPDLEQQCN IEELSRLVMGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------KE------------- ------------------------------------------------------------ ----------------------------------------------NGTSATGRCAAEGA CGGSSAAEE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I ESDHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SC------------------------------------- ------------------------------------------------------------ ---------------------------------------------DSSHSSRSN-PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TQ----------------- -----------------------PFVLPMGVMARNEEYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDKDRFGFIWLE LKSFSLYSRLTDNLPHAHAPDL------------ERF-----------------EAMLRN MQS-WTS >ENSACLP00000040896 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GK-------------GRFDAGA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGP---------ERGVAATAGPSDACEYGSGR-------- ------------------------------------------------------------ ------------------------------------------------------------ -------VNTGGFLDRTS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LAE LPPELLVEIFSLLPGTTLSNVALVCKKFRQLLKTETIW-------------------RRR CI---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMREDLRKVEAR-GVTSQDLYVK-------------------------------LL--- -----------------------------YPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFQIHMMESNKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAKPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGMSARATKLTGDPNVPAGQLTLDVNLCRPVVLPDLEQQCN IEELSRLVMGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------KE------------- ------------------------------------------------------------ ----------------------------------------------NGTSATGRCAAEGA CGGSSAAEE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M ESDHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SC------------------------------------- ------------------------------------------------------------ ---------------------------------------------DSSHSSRSN-PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TQ----------------- -----------------------PFVLPMGVMARNEEYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDKDRFGFIWLE LKSFSLYSRLTDNLPHAHAPDL------------ERF-----------------EAMLRN MQS-WTS >ENSPNYP00000018430 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GK-------------GRFDAGA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGP---------ERGVAATAGPSDACEYGSGR-------- ------------------------------------------------------------ ------------------------------------------------------------ -------VNTGGFLDRTS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LAE LPPELLVEIFSLLPGTTLSNVALVCKKFRQLLKTETIW-------------------RRR CI---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMREDLRKVEAR-GVTSQDLYVK-------------------------------LL--- -----------------------------YPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFQIHMMESNKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAKPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGMSARATKLTGDPNVPAGQLTLDVNLCRPVVLPDLEQQCN IEELSRLVMGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------KE------------- ------------------------------------------------------------ ----------------------------------------------NGTSATGRCAAEGA CGGSSAAEE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M ESDHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SC------------------------------------- ------------------------------------------------------------ ---------------------------------------------DSSHSSRSN-PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TQ----------------- -----------------------PFVLPMGVMARNEEYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDKDRFGFIWLE LKSFSLYSRLTDNLPHAHAPDL------------ERF-----------------EAMLRN MQS-WTS >ENSACLP00000041162 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GK-------------GRFDAGA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGP---------ERGVAATAGPSDACEYGSGR-------- ------------------------------------------------------------ ------------------------------------------------------------ -------VNTGGFLDRTS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LAE LPPELLVEIFSLLPGTTLSNVALVCKKFRQLLKTETIW-------------------RRR CI---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMREDLRKVEAR-GVTSQDLYVK-------------------------------LL--- -----------------------------YPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFQIHMMESNKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAKPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGMSARATKLTGDPNVPAGQLTLDVNLCRPVVLPDLEQQCN IEELSRLVMGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------KE------------- ------------------------------------------------------------ ----------------------------------------------NGTSATGRCAAEGA CGGSSAAEE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M ESDHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SC------------------------------------- ------------------------------------------------------------ ---------------------------------------------DSSHSSRSN-PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TQ----------------- -----------------------PFVLPMGVMARNEEYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDKDRFGFIWLE LKSFSLYSRLTDNLPHAHAPDL------------ERF-----------------EAMLRN MQS-WTS >ENSHBUP00000028944 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GK-------------GRFDAGA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGP---------ERGVAATAGPSDACEYGSGR-------- ------------------------------------------------------------ ------------------------------------------------------------ -------VNTGGFLDRTS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LAE LPPELLVEIFSLLPGTTLSNVALVCKKFRQLLKTETIW-------------------RRR CI---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMREDLRKVEAR-GVTSQDLYVKRVNPRVKSGRFMKLLP--DYEHMDYKDVYTHLL--- -----------------------------YPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMMESNKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAKPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGMSARATKLTGDPNVPAGQLTLDVNLCRPVVLPDLEQQCN IEELSRLVMGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------KE------------- ------------------------------------------------------------ ----------------------------------------------NGTSATGRRAAEGA CGGSSAAEE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M ESDHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SC------------------------------------- ------------------------------------------------------------ ---------------------------------------------DSSHSSRSN-PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TQ----------------- -----------------------PFVLPMGVMARNEEYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDKDRFGFIWLE LKSFSLYSRLTDNLPHAHAPDL------------ERF-----------------EAMLRN MQS-WTS >ENSNBRP00000005785 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GK-------------GRFDAGA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGP---------ERGVAATAGPSDAYEYGSGR-------- ------------------------------------------------------------ ------------------------------------------------------------ -------VNTGGFLDRTS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LAE LPPELLVEIFSLLPGTTLSNVALVCKKFRQLLKTETIW-------------------RRR CI---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKVEAR-GVTSQDLYVKRVNPRVKSGRFMKLLP--DYEHMDYRDVYTHLL--- -----------------------------YPYRHILGLWQPDIG---------------- ---------------PYGGLLNVVVGSFPLLHKTATYSKYWYKGTYHLGSAGKFFKIFFI QV-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMMESNKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAKPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGMSARATKLTGDPNVPAGQLTLDVNLCRPVVLPDLEQQCN IEELSQLVMGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------KE------------- ------------------------------------------------------------ ----------------------------------------------NGTSATGRCAAEGA CGGSSAAEE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M ESNHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SC------------------------------------- ------------------------------------------------------------ ---------------------------------------------DSSHSSRSN-PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TQ----------------- -----------------------PFVLPMGVMARNEEYPR----ACRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDKDRFGFIWLE LKSFSLYSRLTDNLPHAHAPNL------------ERF-----------------EAMLRN MQS-WTS >ENSONIP00000018536 ------------------------------------------------------------ ------------------------------------------------------------ ----------MK-------------------------HRQICFQTNFLPSQRLENMVKHI FPL--------------------------------ASQVP-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GK-------------GRFDAGA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGP---------ERGVAATAGPSDAYEYGSGR-------- ------------------------------------------------------------ ------------------------------------------------------------ -------VNTGGFLDRTS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LAE LPPELLVEIFSLLPGTTLSNVALVCKKFRQLLKTETIW-------------------RRR CI---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKVEAG-GVTSQDLYVK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMMESNKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAKPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTSARATKLTGDPNVPAGQLTLDVNLCRPVVLPDLEQQCN IEELSRLVMGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------KE------------- ------------------------------------------------------------ ----------------------------------------------NGTSATVRCAAEGA CGGSSTAEE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M ESDHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SC------------------------------------- ------------------------------------------------------------ ---------------------------------------------DSSHSSRTN-PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TQ----------------- -----------------------PFVLPMGVMARNEEYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDKDRFGFIWLE LKSFSLYSRLTDTLPHAHAPNL------------ERF-----------------EAMLRN MQS-WTS >ENSMALP00000031590 ------------------------------------------------------------ ------------------------------------------------------------ ----------M------------------------------------------------- ---------------------------------------TFDTADPPK------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KKM--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--E--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GQ-------------KQGDVPG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GGP---------ESGV-ATAGPSDACEYGRGH-------- ------------------------------------------------------------ ------------------------------------------------------------ -------VNRGGFLDRTS------------------------------------------ ---------------------------SGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LTE LPPELLVEIFSLLPGTALPAVALICKKFRQILNTETIW-------------------RRR CV---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMNEDLRKMEAG-GVSSRDLYVKRVNPRVKSGRFMKLLP--DYEHMDYRDVYTHLL--- -----------------------------HPYRYILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWESKKATVE-----------CMYG -HKGPHKGDIQTVKMDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTSARATKLTGDPNVPAGQLTLDIDLSQPVVLPDLEHQHN IEELSRLVLGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QAK------------ ------------------------------------------------------------ ----------------------------------------GPSAPVIG-------AAEGA CGGASGAEG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------IAED-------------------------- ------------------------------------------------------------ -----------------------QPGP--------------------------------- ---------------G-SSTTP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDHFGFIWLE LKSFSLYSRLTDHLAHAHAPNM------------ERF-----------------EAMLHN MQS-WTS >ENSAOCP00000013003 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GQ-------------RLGDAGG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGP---------DRGV-ATAGPSDA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ----GEYVNRGGFLDHRS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPES------------------- ---------------------------------------------------------LVE LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RRR CM---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKMEAG-GVSSQDLYVK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWESNKATVE-----------CMYG -HKGPHKGDIQTGKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGNSARATKLTGDPNVPAGQLTLDVDLSRPVVLPELEQQRN IEELSRLVLGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QA------------- ------------------------------------------------------------ ----------------------------------------------NGTPATVRQAAEGA CGGASGAEE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M EADHVACVD--------------------------------------------------- ------------------------------------------------------------ ---------------------NCQSGPSG------------------------------- --------------SS-SSSNP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AL----------------- -----------------------PFILPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLAHAHAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSAPEP00000010924 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GQ-------------RLGDAGG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGP---------DRGV-ATAGPSDA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ----GEYVNRGGFLDRRS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPES------------------- ---------------------------------------------------------LVE LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RRR CM---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKMEAG-GVSSQDLYVKRVNPRVKSGRFMKLLP--DYEHMDYRDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWESNKATVE-----------CMYG -HKGPHKGDIQTGKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGNSARATKLTGDPNVPAGQLTLDVDLSRPVVLPELEQQRN IEELSRLVLGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QA------------- ------------------------------------------------------------ ----------------------------------------------NGTPATVRQAAEGA CGGASGAEE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M EADHVACVD--------------------------------------------------- ------------------------------------------------------------ ---------------------NCQSGPSG------------------------------- -----------------SSSNP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AL----------------- -----------------------PFILPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLAHAHAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSAPOP00000025829 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GQ-------------RLGDAGG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGP---------DRGV-ATAGPSDA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ----EEYVNRGGFLDRRS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LVE LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RRR CM---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKMEAG-GVSSQDLYVKRVNPRVKSGRFMKLLP--DYEHMDYRDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGNSARATKLTGDPNVPAGQLTLDVDLSRPVVLPELEQQRN IEELSRLVQGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QA------------- ------------------------------------------------------------ ----------------------------------------------NGTPATVRQAAEGA CGGASGAEE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M EADHAACVD--------------------------------------------------- ------------------------------------------------------------ ---------------------SCQSGP--------------------------------- ---------------S-SSSNP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AL----------------- -----------------------PFILPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLAHAHAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSSPAP00000009794 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEEQIV---------------------------------- ----------------------------------GQ-------------RLGDAGGS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SSSGGP---------ERGA-ATAGPSDAG-------------- ------------------------------GEY--------------------------- ------------------------------------------------------------ -GSSGGHVNRGGFLDRRS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LAE LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RRR CM---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKMEAG-GVSSQDLYVKRVNPRVKSGRFMKLLP--DYEHMDYRDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTSARATKLTGDPNVPAGQLTLDVDLSRPVVLPELEQQRN IDELSRLVLGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QA------------- ------------------------------------------------------------ ----------------------------------------------NGTPATVRRPAEGA CGGAGGAEE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------V VAGDAACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SCHSGN--------------------------------- ---------------S-SSNNP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AL----------------- -----------------------PFVLPFGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLD LKSFSLYSRLTDHLPHAHAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSPRNP00000021200 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------AQ-------------RQTDAGG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGP--------AERGV-ATAGPSDACEHGSGH-VN----- -----------------RG------RSLDCS----------------------------- ------------------------------------------------------------ -----------------S------------------------------------------ ---------------------------TGPT----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LAE LPPELLVEIFSLLPGTVLPSVALVCKKFRQILNTETIW-------------------RRR CM---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKMEAG-GVSSQDLYVKRVNPRVKSGRFMKLLP--DYEHMDYRDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMFSFHGKFARATKLTGDPNVPAGQLTLDVDLSRPVVLPELDQQRN IEEVSRLVLGIHEQAQR------------------------------------------- ------------------------------------------------------------ --------------------------------------EM---------------EPQSS GTS-------------ATVKTAEGACDDAGASGGDGMETDHGAC----SE---------- --------------------------------------------------GCL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGPS-------------------------------- ---------------S-SKTNP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLAHAHAPSM------------ERF-----------------EAMLRN MQS-WTS >ENSSDUP00000024280 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEGERIV---------------------------------- ----------------------------------GK-------------RQGDVCG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GGGP---------ESGV-ATAGPSDACEYGSGH-------- ------------------------------------------------------------ ------------------------------------------------------------ ------HVNRGGSLNRTS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQT------------------- ---------------------------------------------------------LAE LPPELLVEIFSLLPGTALPNVALICKKFRQILSTETIW-------------------RRR CI---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKMEVG-GVSSRELYVK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWETKKASVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PTLPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTSARATKLTGDPNVPAGQLTLDVDLSRPVVLPDLEHQRK IEELSRLVLGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------RAK------------ ------------------------------------------------------------ ----------------------------------------DSSATVNG-------AAEGA CGGASGAEG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M DIDHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SCEPGPSS------------------------------- --------------SS-SSSSP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLAHAHAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSSLDP00000028555 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEGERIV---------------------------------- ----------------------------------GK-------------RQGDVCG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------GGGP---------ESGV-ATAGPSDACEYGSGH-------- ------------------------------------------------------------ ------------------------------------------------------------ ------HVNRGGSLNRTS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQT------------------- ---------------------------------------------------------LAE LPPELLVEIFSLLPGTALPNVALICKKFRQILSTETIW-------------------RRR CI---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKMEVG-NVSSRELYVKRVNPRVKSGRFVKLLP--DYKHMDYRDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWETKKASVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PTLPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGMSARATKLTGDPNVPAGQLTLDVDLSRPVVLPDLEHQRK IEELSRLVLGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------RAK------------ ------------------------------------------------------------ ----------------------------------------DSSATVNG-------AAEGA CGGASRAEG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M DIDHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SCEPGP--------------------------------- ---------------S-SSSSP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLAHAHAPNM------------ERF-----------------EAMLCN MQS-WTS >ENSLCAP00010035855 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEGERIV---------------------------------- ----------------------------------GQ-------------RQGNV------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GGGSLSRTS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LVE LPPELLVEIFSLLPGTALPNVALVCKKFRQILNTETIW-------------------RRR CI---------------------------------------------------------- ---------------K-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKMEVG-GVSSRDLYVK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-MFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PLMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTSARATKLTGDPNVPAGQLTLDVDLSRPVVLPDLEQQRQ IEELSRLVLGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QAK------------ ------------------------------------------------------------ ------------------------------------------------------------ --------GGS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------AAVS---- ---GAAVG------------------------ACGG-----------------AGGGT-- ---------------------------------------------------------EAM DVDHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------GCQPGPSS------------------------------- --------------SS-SSSTST---------------------------------TT-- ------------------------------------TTT----TTT-------NLPE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLAHAHAPNM------------ERF-----------------EAMLQN MQS-WTS >ENSORLP00000030466 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNEQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEGERIV---------------------------------- ----------------------------------GQT-----------QRRAEAGC---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------SGGP---------DSAV-ASAGPSDAGEDGSGH-VNTA--- --------------ASSRG----NPRP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PQS------------------- ---------------------------------------------------------LAD LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RKR CM---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMNEDLRKMEAG-GVCSQDLYVKRVNPRVKSGRFMKLLP--DYEHMDYRDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLLESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PARPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSSARATKLTGDPNVPAGQLTLDIDLRRPVVLPDLEQQRN IEELSRLVLRIHEEVQG------------------------------------------- ------------------------------------------------------------ --------------------------------------DAGQHDSVAPPTVKSAEE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------EGA CGG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSGPE PEEG-------------------------------------------------------- ------------------------------------------------------------ --DHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SCQPGP--------------------------------- ---------------S-RSSSP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLPHAHAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSORLP00020034399 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNEQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEGERIV---------------------------------- ----------------------------------GQT-----------QRRADAGC---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------SGGP---------DSAV-ASAGPSDAGEDGSGH-VNTA--- --------------ASSRG----NSRP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PQS------------------- ---------------------------------------------------------LTE LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RKR CM---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMNEDLRKMEAG-GVCSQDLYVKRVNPRVKSGRFMKLLP--DYEHMDYRDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLLESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PARPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSSARATKLTGDPNVPAGQLTLDIDLRRPVVLPDLEQQRN IEELSRLVLRIHEEVQG------------------------------------------- ------------------------------------------------------------ --------------------------------------DAGQHDSVAPPTVKSAEE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------EGA CGG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSGPE PEEG-------------------------------------------------------- ------------------------------------------------------------ --DHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SCQPGP--------------------------------- ---------------S-RSSSP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLPHAHAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSORLP00015010536 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNEQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEGERIV---------------------------------- ----------------------------------GQT-----------HRRADAGC---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------SGGP---------DSAV-ASAGPSDAGEDGSGH-VNTA--- --------------ASSRG----NSRP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PQS------------------- ---------------------------------------------------------LAE LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RKR CM---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMNEDLRKMEAG-GVCSQDLYVKCVNPRVKSGRFMKLLP--DYEHMDYRDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLLESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PARPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSSARATKLTGDPNVPAGQLTLDIDLRRPVVLPDLEQQRN IEELSRLVLRIHEEVQG------------------------------------------- ------------------------------------------------------------ --------------------------------------DAGQHDSEAPPTVKSAEE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------EGA CGG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSGPE HEEG-------------------------------------------------------- ------------------------------------------------------------ --DHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SCQPGP--------------------------------- ---------------S-RSSSP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLPHAHAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSOMEP00000010118 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEGERIV---------------------------------- ----------------------------------GQ-------------RRTDAGC---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGP---------DSAV-ASAGPSDAGEYGNGH-VN----- -----------------RGASGDNSRP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PQS------------------- ---------------------------------------------------------LAE LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RKR CM---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMNEDLRKMEAG-GVCSQDLYVKRVNPRVKSGRFMKLLP--DYEHMDYRDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLWESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSSARATKLTGDPNVPAGQLTLDIDLRRPVVLPDLEQQRN IEELSRLVLRIHEEVQS------------------------------------------- ------------------------------------------------------------ --------------------------------------DAEQQDSEAPPVVKSAEE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------EGA CGG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSGPE PEEV-------------------------------------------------------- ------------------------------------------------------------ --DHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SCQPGP--------------------------------- ---------------S-SSSSP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLPHAHAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSLCRP00005008453 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RQNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GQKQ-------------GDVGGRAG- ------------------------------------------------------------ --------------------------------------------------GA-------- -------------------GGAG----------------------------------GAG GPNS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GAD--------------------TAGPSD----GSGH-VN----- -----------------RGGCL-------------------------------------- ------------------------------------------------------------ ----------------RS------------------------------------------ ---------------------------TGPA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LAD LPPELLVEIFSLLPGTALPNVALVCKKFKQILTTETIW-------------------RRR CM---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKDDLRKMEVG-GVSSQDLYVKRVNPRVKSGRFMKLLP--DYEHMDYKDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PVMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHEATARATKLTGDPNVPAGQLTLDVDLNRAVVLPDLEQQRN IEELSRLVLGVHKEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------AE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QAM------------ ------------------------------------------------------------ ----------------------------------------VTSA--------VRGAAEGA CG--------SD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GAA---------------EGVEADW------- ------------------------------------------------------------ ------------------------------------------------------------ ----GACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SCQPGP--------------------------------- ---------------SNSTTNH-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------EQ----------------- -----------------------PFVLPLGVTARNEVYPR----TCRQCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDQDRFGFIWLE LKSFSLYSRLTDHLAHAHAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSCGOP00000046153 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RQNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GQKQAD----R--SYRQ--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---ELLVEIFSLLPGTALPNVALVGKKFRQILNTETIW-------------------RRR CM---------------------------------------------------------- ---------------A-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKMEVG-GVSSRDLYVKRINPRVKSGRFMKLLP--DYEPMDYRDVYAHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWESNNASVE-----------CMYG -HKGPHKGDIQTGKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PVMPSDLLHPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTSARATKLTGDPNVPAGQLTLDVDLSRSVVLPDLEHQRN IEELSRLVLGVHEDVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QAM------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------DTS----ATVRGAAEVACGDASAAEGVE------------------------ -------------------AGHV------------------------------------- -----------------TGSGSCQPGP--------------------------------- ---------------S-STTSP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDNLAHSHAPTM------------ERF-----------------EAMLCN MQS-WTS >ENSMAMP00000008049 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNNLQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--E--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GQ-------------RQ--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SGVS----VGVGGGGGPV------------SGAANAGL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SDACEYGSGH-------- ------------------------------------------------------------ ------------------------------------------------------------ -------------MNRAG------------------------------------------ ---------------------------SGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LPQS------------------- ---------------------------------------------------------LAE LPPELLVEIFSRLPGTALPVVALVCKKFRQILNTETIW-------------------RTR CV---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKMEAG-GVSSRDLYVKRVNPRVKSGRFMKLLP--DYEHMDYRDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAMPSALLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTCARATKLTGDPNVPAGQLTLDVDLSRPVVLPDLEQQRS IEELSRLVLGIHEEVES------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------AQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QAK------------ ------------------------------------------------------------ ----------------------------------------SPSVTVKG-------AAEGA CGGGSGEEE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M EADHGSCSG--------------------------------------------------- ------------------------------------------------------------ ---------------------SEQPGP--------------------------------- ---------------S-SITNP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFILPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLAHAHAPNI------------ERF-----------------EAMLHN MQS-WTS >ENSPFOP00000015484 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MDEEEEERIV---------------------------------- ----------------------------------GQ-------------RRSDAGS---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGPGRVAAAAAA-----ATAEPSDACEYGSGHNTN----- -----------------RGG---------------------------------------- ------------------------------------------------------------ ----------------SN------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPES------------------- ---------------------------------------------------------LME LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RRR CV---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMREDLRKMEAT-GVSSQDLYVKRVVPRVKSGRFMKLLP--DYEHMDYRDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLLESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PLMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGMSARATKLTGDPNVPAGQLTLDVDLSQPVDLPELDQQRN IDVLSRIILGIHEKVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ -------------------------------------------------PA--------- ----------SD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------ASACVGRAEEEADGAAAEET EVDHGACAD--------------------------------------------------- ------------------------------------------------------------ ---------------------ACQSGP--------------------------------- ---------------S-GSSSS-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLPHAHAPSM------------ERF-----------------EAMLRN MQS-WTS >ENSPLAP00000014395 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNDQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GQ-------------RRSDAGS---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGPGRVAAAAAA-----ATAEPSDACEYGSGHNTN----- -----------------RRG---------------------------------------- ------------------------------------------------------------ ----------------SN------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPES------------------- ---------------------------------------------------------LME LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RRR CV---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMREDLRKMEAT-GVSSQDLYVK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLLESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PLMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGMSARATKLTGDPNVPAGQLTLDVDLSQPVDLPELDQQRN IDVLSRIILGIHEKVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ -------------------------------------------------PA--------- ----------SD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------ASACVGRAEEEADGAAAEET EVDHGACAD--------------------------------------------------- ------------------------------------------------------------ ---------------------ACQSGP--------------------------------- ---------------S-GSSSS-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLPHAHAPSM------------ERF-----------------EAMLRN MQS-WTS >ENSPMEP00000005031 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNDQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GQ-------------RRSDAGS---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGPGRVAAAAAA-----ATAEPSDACEYGSGHNTN----- -----------------RRG---------------------------------------- ------------------------------------------------------------ ----------------SN------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPES------------------- ---------------------------------------------------------LME LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RRR CV---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMREDLRKMEAT-GVSSQDLYVKRVVPRVKSGRFMKLLP--DYEHMDYRDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLLESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PLMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGMSARATKLTGDPNVPAGQLTLDVDLSQPVDLPELDQQRN IDVLSRIILGIHEKVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ -------------------------------------------------PA--------- ----------SD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------ASACVGRAEEEADGAAAEET EVDHGACAD--------------------------------------------------- ------------------------------------------------------------ ---------------------ACQSGP--------------------------------- ---------------S-GSSSS-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLPHAHAPSM------------ERF-----------------EAMLRN MQS-WTS >ENSPREP00000027158 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNDQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GQ-------------RRSDAGS---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGPGRVAAAAAA-----ATAEPSDACEYGSGHNTN----- -----------------RGG---------------------------------------- ------------------------------------------------------------ ----------------SN------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPES------------------- ---------------------------------------------------------LME LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RRR CV---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMREDLRKMEAT-GVSSQDLYVKRVIPRVKSGRFMKLLP--DYEHMDYRDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLLESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PLMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGMSARATKLTGDPNVPAGQLTLDVDLSQPVDLPELDQQRN IDVLSQIILGIHEKVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ -------------------------------------------------PA--------- ----------SD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------TSACVGRAEEETDGAAAEAT EVDHGACAD--------------------------------------------------- ------------------------------------------------------------ ---------------------ACQSGP--------------------------------- ---------------S-GSSSS-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AL----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLPHSHAPSM------------ERF-----------------EAMLRN MQS-WTS >ENSGAFP00000032323 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MDEEEEERIV---------------------------------- ----------------------------------GQ-------------RRSDAGS---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGPGRV--AAAA-----ATAEPSDACEYGSGHNAN----- -----------------RGG---------------------------------------- ------------------------------------------------------------ ----------------SN------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPES------------------- ---------------------------------------------------------LME LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RRR CA---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMREDLRKMEAT-GVSGQDLYVKRVIPRVKSGRFMKLLP--DYEHMDYKDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLLESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PLMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHEMSARATKLTGDPNVPAGQLTLDVDLSQPVDLPELDQQRN IDVLSRIILGIHEKVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ -------------------------------------------------PA--------- ----------SD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------TSACVGHAEEEADDAAAEAT EVDHGACGD--------------------------------------------------- ------------------------------------------------------------ ---------------------ACQSGP--------------------------------- ---------------S-GSSSS-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDKDRFGFIWLE LKSFSLYSRLTDHLPHAHAPSM------------ERF-----------------EAMLRN MQS-WTS >ENSXCOP00000027475 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNDQQ------------------- ------------------EQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEEKIV---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GG---------------------------------------- ------------------------------------------------------------ ----------------SN------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPES------------------- ---------------------------------------------------------LME LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RRR CA---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMREDLRKMEAT-GVSSQDLYVK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLLESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PLMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHEMSARATKLTGDPNVPAGQLTLDVDLSQPVDLPELDQQRN IDVLSRIILGIHEKVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ -------------------------------------------------PA--------- ----------SD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------TSACVEHAEEEADDAAAEET EVDHGACVD--------------------------------------------------- ------------------------------------------------------------ ---------------------ACQSGP--------------------------------- ---------------S-GSSSS-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLMDHLPHAHAPSM------------EPF-----------------EAMLRN MQS-WTS >ENSXMAP00000028886 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RSDQQ------------------- ------------------EQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEEKIV---------------------------------- ----------------------------------GQ-------------RRSDAGS---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------RGGPGRVAAVAAA-----ATAEPSDTCEYGSGHNTN----- -----------------RGG---------------------------------------- ------------------------------------------------------------ ----------------SN------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPES------------------- ---------------------------------------------------------LME LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RRR CA---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMREDLRKMEAT-GVSSQDLYVKRVIPRVKSGRFMKLLP--DYEHMDYKDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLLESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PLMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHEMSARATKLTGDPNVPAGQLTLDVDLSQPVDLPELDQQRN IDVLSRIILGIHEKVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ -------------------------------------------------PA--------- ----------SD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------TSACVEHAEEEADDAAAEET EVDHGACVD--------------------------------------------------- ------------------------------------------------------------ ---------------------ACQSGP--------------------------------- ---------------S-GSSSS-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLPHAHAPSM------------EPF-----------------EAMLRN MQS-WTS >ENSCVAP00000004664 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRCRRR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNDQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MEEEEEERIV---------------------------------- ----------------------------------GQ-------------RRSEAGS---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------SGGPGRV-AAADA-----ATAGPSDACEYGSGH-VN----- -----------------RGE---------------------------------------- ------------------------------------------------------------ ----------------SN------------------------------------------ ---------------------------TKPL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPES------------------- ---------------------------------------------------------LIE LPPELLVEIFSLLPGTVLPNVALVCKKFRQILKTETIW-------------------RRR CV---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKMEAG-GVTSQDLYVKRVIPRVKSGRFMKLLP--DYEHMDYKDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLLESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSMPSDLLEPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTSARATKLTGDPNVPAGQLTLDVDLSQPVDLPELDQQKN IDVLSRIISGIHEKVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------H--------------------------------------- ------------------------------------------------------------ -------------------------------------------------PA--------- ----------SDSSAS-------------------------AGHP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AEEAG------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AAAAAKVV--------------------------ED-------------------- --DHGACED--------------------------------------------------- ------------------------------------------------------------ ---------------------ASQSEP--------------------------------- ---------------S-SSSHP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLPHADAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSFHEP00000007873 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNDQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GQ-------------RRSDAGT---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------AGGPGRV-AAAAA-----ATAGPSDACEDGSGH-IN----- -----------------RGG---------------------------------------- ------------------------------------------------------------ ----------------SN------------------------------------------ ---------------------------RGPL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPES------------------- ---------------------------------------------------------LME LPPELLVEIFSLLPGTVLPNVALVCKKFRQILNTETIW-------------------RRR CV---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKMEAG-GVSSQDLYVK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLMESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PVMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTSARATKLTGDPNVPAGQLTLDVDLSQPVDLPELDKQRN IDELSRIILEIHGKVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------AE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ -------------------------------------------------PA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------CGPS---------- ---------AN-----------VGRAAEGA------------------------------ -------------------------------------------------------GGVER AAEEAM------------------------------------------------------ EVDHGACTD--------------------------------------------------- ------------------------------------------------------------ ---------------------ACQSGP--------------------------------- ---------------S-SSSPP-------------------------------------- -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AK----------------- -----------------------PFVLPLGVIARNEVYPR----TCRKSFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDNLPHAHAPNM------------ERF-----------------EAMLCN MQS-WTS >ENSTNIP00000015122 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RQNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEGEERIV---------------------------------- ----------------------------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GGGGPENGVVVTAGPSD-- ----------------------------------------------------PLPRSLAD LPPELLVEIFSLLPGTALPNVALVCKKFKQILKTETIW-------------------RRR CV---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKDDLRKVEVG-GVSSHDLYVK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLWESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTGHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAAPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHQKSARATKLTGDPNVPAGQLTLEINLSRPVVLPDLEQQCN IEELSRLVLGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------AE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QA------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GDTGEGACGSDASGDEAQA------ ------------------------------------------------------------ --DHAAC----------------------------------------------------- ------------------------------------------------------------ -------------------AGNCQPGPNR------------------------------- --------------TS-------------------------------------------- --------------------------------------AHRHED---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------Q----------------- -----------------------PFVLPLGVTARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDQDRFGFIWLE LKSFSLYSRLTDQLAHAHAPNV------------ERF-----------------EAMLRN MQS-WTS >ENSTRUP00000000759 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RQNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEGEERIV---------------------------------- ----------------------------------GLRQ---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------VGGGI------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GGP---------DSGV-VTAGPSDACDCGGGH-------- --------------------------------VSRR------DCL--------------- ------------E--------------------------------------------RTA KGF--------------------------------------------------------- ------------------------------P----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQF------------------- ---------------------------------------------------------LAD LPPELLVEIFSLIPGTALPNVALVCKKFKQILKTETIW-------------------RRR CV---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKDDLRKLEVG-GVSSHDLYVK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLWESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PATPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHHKSARATKLTGDPNVPAGQLTLEINLSRPVVLPDLEQLCN IEELSRLVLGIHEEVHR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------AE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QA------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NHTKEGACGSDSAEDEVDA------ ------------------------------------------------------------ --DHGAC----------------------------------------------------- ------------------------------------------------------------ -------------------PGNCQPGPSS------------------------------- --------------TS-------------------------------------------- --------------------------------------AHQHDD---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------Q----------------- -----------------------PFVLPLGVTARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDQDRFGFIWLE LKSFSLYSRLTDQLAHAHAPNM------------ERF-----------------EDMLRN MQS-WTS >ENSGACP00000015374 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MEEEEEEQIV---------------------------------- ----------------------------------GP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TAGALDRGG------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RPQS------------------- ---------------------------------------------------------LAD LPPELLVEIFSLLPGTALPSVALVGKKFRQILNTETIW-------------------RRR CM---------------------------------------------------------- ---------------A-------------------------------------------- -----------------------------------------------------------E FDMKEDLRRMEVG-GVSSRDLYVK-------------------------------LL--- -----------------------------HPFRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMLESNEATVE-----------CMYG -HKGPHKGDIQTGKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PLMPSDLFHPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGIYLRATKLTGDPNVPAGQLTLDVDLSRPVVLPDLEHQRN IEELSRLVLGVHAEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- -------------------------------------------------EQ--------- ---------------------------------------EQAKDAPAAGRG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AAEGA CG---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------NASAADWVEEGRV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----ACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SCQPGP--------------------------------- ---------------S-TSTSP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDHFGFIWLE LKSFSLYSRLTDQLAHAHAPNM------------ERF-----------------EAMLFN MQS-WTS >ENSGWIP00000008223 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RNNQQ------------------- ------------------DQ-CSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEGERIV---------------------------------- ----------------------------------GQ-------------RQAE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------N------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LAE LPPELLVEIFSLLPGTVLSNVALVCKKFRQILNTETIW-------------------RRR CM---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKEDLRNIEAG-GVSSQDLYTKRVDPRLKSGRFVKVLPDHDHEHMDYRDVFTRLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLGESKKATVE-----------CMYG -HKGPHKGDIQTGKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSLPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIIMLSFHGTSARATKLTGDPNVPAGQLTLDVNLSRPMVLPELEQQRS IEELSRLVLGIHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------AA----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QA------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------SGTSATGLRGTDRVSGSASESEGMDVT------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EHGACADSSQSAPTT------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------S-TTTSP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VQ----------------- -----------------------PFILPMGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDQLVHAHAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSKMAP00000005088 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRSC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RSNQQ------------------- ------------------DQGGSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEGEQIV---------------------------------- ----------------------------------GARKSETGGRR--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GGPGGVVA---------ATAGPSDAREYGSGR-------- --------------A--------------------------------------------- ------------------------------------------------------------ ---------------RTS------------------------------------------ ---------------------------SGPQ----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPES------------------- ---------------------------------------------------------LAE LPPELLVEIFSLLPGTVLPNVALVCRKFRQILNMETIW-------------------RRR CM---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMNEDLRKMEAG-GVSSQDLYVKRVSLRVKSGRFMKLLP--DYENMDYKDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLLDSKKATVE-----------CMYG -HRGPHKGDIQTVKKDEFSTKCNQTDYHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSMPSDLLEPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTSARATKLTGDPNVPAGQLTLDIDLSRPVVLPDLEQQRK IEELSRIIMRIHDEEQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------VE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QA------------- ------------------------------------------------------------ ----------------------------------------------NGA------SADGA CGGASEGEE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M EEDHGASSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SCQLGP--------------------------------- ---------------S-GSSSS-------------------------------------- -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AL----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDHLEHAHAPSM------------ERF-----------------EAMLRN MQS-WTS >ENSPMGP00000018422 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RQNQQ------------------- ------------------DQ-CSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------ALRQSDV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CGGP------------------------------------- ------------------------------------------------------------ ------------ES----------------------------ARTVTAGPRDAPGPLR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------PRALSE LPPELLVEIFSTLPGTVLPNVALVCKKFRQILNTETIW-------------------RRR CV---------------------------------------------------------- ---------------A-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKMEVG-AVSSRDLYVK-------------------------------LL--- -----------------------------HPYRHILGIWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLWESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PPLPSALLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTSARATKLTGDPNVPAGQLTLDVDLSRPVVLPDLESQRS IEELSRLVLGVHAEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------ME----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QAKE----------- ------------------------------------------------------------ -------------------------------ASTAASTSTE----------------EGA CGG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EE----------------------- ----RSPDQSASSENCQPES---------------------------------------- ------------------------------------------------------------ ---------------S-GSSNP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDQDRFGFIWLE LKSFSLYSRLTDHLPHAQAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSATEP00000030451 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------PHNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--E--- ----------------MDEEEEERIV---------------------------------- ----------------------------------AQ-------------RQ--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------VDVDGGSKSSVAAA-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------AIAGPSDACEYGSGR-------- ------------------------------------------------------------ ------------------------------------------------------------ -------VNRGGFPDRAG------------------------------------------ ---------------------------TAPV----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QPQT------------------- ---------------------------------------------------------LSD LPPELLVEIFSLLPGPALADVALVCKKFRRILNTETIW-------------------RRR CV---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKIEAG-GISSRDLYVKRVNPRVKSGRFMKLLP--DYEHMDYKDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLWESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-DEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAMPSDLLQAGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTFAKATKLTGDPNVPAGQLTLDVDLSRPVVLPDLEQQRN IEELSRLVMGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------AE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GASATGKGAAERACGSGEEG------------ ------------------------------------------------------------ -----------------------------------------------------------I EAEHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------SCQPSS--------------------------------- ---------------S-TSTNP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GQ----------------- -----------------------PFVLPLGVMARNDVYPR----TCRKSFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLMDHLEHAHAPNM------------ERF-----------------EAMLQN MQS-WTS >ENSCSEP00000022378 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGHSRRC-RR------------------R------------------K------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RPNQQ------------------- ------------------GQ-ASD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MEEEEEERIV---------------------------------- ----------------------------------GP-------------RPGD------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------T------------------- ---------------------------------------------------------LVE LPPELLVEIFSLLPGTVLPNVALVCKKFRHLLNTETIW-------------------RRR CI---------------------------------------------------------- ---------------D-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKMEVG-QVSSRDLYVK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRVHLWDNQKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSMPSNLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTSARATKLTGDPNVPAGQLTLDVDLRRPIILPDLEQQCR IEKLSRLVIQVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------AE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QAK------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GLVVTSSGGEDGCCSDASRGEGMKAD--------------------------- ------------------------------------------------------------ ----GACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------NCQPGPSSSS----------------------------- -------------SSS-SSSVP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPVGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDQDRFGFIWLE LKSFSLYSRLTDYLPHAHAPNM------------ERF-----------------EAMLHN MQS-WTS >ENSSMAP00000012222 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RQNQQ------------------- ------------------GQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEGERIV---------------------------------- ----------------------------------GQ-------------RPGDGGG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GGGGP---------EGGV-ATAGPSDAGEYGCGH-FN----- -----------------RGGCAN------------------------------------- ---------------------------------------------------------RT- ----------------AS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQT------------------- ---------------------------------------------------------LVE LPPELLVEILSRLPGTALPSVALVCKKLRQLLNTETIW-------------------RRR CI---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FDMKEDLRKMEVG-GVSSQELYVKRVDPRVKSGRFMKLLP--DYEHMDYRGVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-RFIIGWMYLPPHDPRVEDAMRRRPLFRVHMLESQKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAMPSALLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHRNSARATKLTGDPNVPAGQLTLDVDLNRPVVLPDLEQQCK IEELSRLVLGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- --SVRRAESASSAVSGA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AAEAA CG---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------ASGAEG------------ ------------------------------------------------------------ -----------------------------------------------------------M EVDHGACSD--------------------------------------------------- ------------------------------------------------------------ ---------------------ACQPGPSSSS----------------------------- ---------------S-SSTSP-------------------------------------- -------------------------------------------------------LD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPMGVMARNKVYPH----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDNLAHAHAPNM------------DRF-----------------EAMLHN MQS-WTS >ENSHCOP00000022888 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------P------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RQNQQ------------------- ------------------VQ-ASD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GQ-------------RRGDA------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------CCGGP---------ESGV-NTAGPS----------------- -----------------------------------RVHRGVVD----------------- ------------------------------------------------------------ -----------------G------------------------------------------ ---------------------------TGHP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQA------------------- ---------------------------------------------------------LSE LPPELLVEIFSLLPGTALPNVALVCKTFRQILNTETIW-------------------RRR CM---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FHMKEDLRKMEVG-GVSSRDLYVK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWETKKATVE-----------CMYG -HKGPHKGDIQTVRKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PAMPSDLIQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHRTSARATKLTGDPNVPAGQLTLDIDLSQPLVLPDLEHQRN IEELSRLVLGVHEQVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------Q--------------------- ------------------VR---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------EGTPATVR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------APAEGAPGDAN VAEADHGVGSN------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GCQPGP--------------------------------- ---------------S-ADTCP-------------------------------------- -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDQDRFGFIWLE LKSFSLYIRLTDHLAHAHAPNL------------ERF-----------------EAMLRN MQS-WTS >ENSMMOP00000023044 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSQRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHNQQ------------------- ------------------DQ-GSN------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GQ-------------RQ--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAESSV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ATSGPSDA-----------HKDG SGHVRRRDRAERQSA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LVD LPPELLVEIFSLLPGTALPEVALVCKKFKQILNTETIW-------------------RRR CA---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMTDDLRKMEAG-GVSSHDLYAK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-HVIIGWMYLPPHDPRVEDPMRRRPLFRIHMLESKNATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EEIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--LAMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHENSARATKLTGDPNVPAGQLTLDVDLSRPIVLPDLEQQRS IEDLSRLVLGIHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------AD----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------QAK------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------VASATARDIAEGAYGSASAAEEVEVDND--------------------- -----ACSDSSH------------------------------------------------ ------PD---------------------------------------------------- ------------------------------------------------------------ ---------------------P-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPLGITARNEVYPR----TCRKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDQDRYGFIWLE LKSFSLYSRLTDHLAHAHAPCV------------ERF-----------------EAMLHN MQS-WTS >ENSELUP00000027076 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHNQP------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---T-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------VISNG---------------------------CGPEILSAAA GPSVAHNAIGEFGSSNVKRLSYEAVVNTGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NPQS------------------- ---------------------------------------------------------LLH LPPELLVEIFSSLPGTELPTLALVCKKFRQILNTETVW-------------------RRR CT---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMREDLRKMEVV-GVSSRELYAK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVE------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWESNRAVVE-----------CMYG -HKGPHKGDIQIGKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PRLPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSRFRATKLTGDPNVPAGQLTLDVDLNRPVRLPDLEHQRS VEELSRLVLGMHEEAQQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----QSPD--------------VAPQ-----------------------RAPNGDGAVAG DAGVESLEAAIDAQSESP-----RPGP--------------------------------- --------------SS-SSSAP-------------------------------------- -------------------------------------------------------SD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFILPLGVMARNEVYPR----TCKMCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDRFGFIWLE LKSFSLYSRLTDRLAHAYAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSHHUP00000014813 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDDEEGVRIV---------------------------------- ----------------------------------GK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TQ------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AVTG---CGGP------------------------------------- ------------------------------------------------------------ ------------ENPSAAAGPSVAHEATAECGRANVRLSYGQS----------------- ----------------AS------------------------------------------ ---------------------------TGQP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NPKS------------------- ---------------------------------------------------------LLD LPPELLVGIFSSLPGTELPNLALVCKTFRQILNTETIW-------------------RRR CT---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMREDLRKIEVV-GVSSRELYAK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFILGWMYLPPHDPRVEDPMRRRPLFRIHMWESNKAAVE-----------CMYG -HKGPHKGDVQTGKNDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PRLPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIIMLSFHGPRARATKLTGDPNVPAGQLTLDVDLNRPVRLPDLEHQRS VEELSRLVLGVHEEAQQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------A--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----QSPD--------------VAPQGVAAGKGAVAGG-GAEGLELAME----------- ------------AQSESP-----QPGPSS------------------------------- --------------SS-SSSAP-------------------------------------- -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------AFVLPLGVMARNEVYPR----TCKMCFYG---TGLIA --------------------GHGFTSPERT------------PGLFILFDEDRFGFIWLE LKSFSLYSRLTDQLAHAYAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSHHUP00000005654 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHNQQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEGERIV---------------------------------- ----------------------------------GE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TQ------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AVT-----GSP------------------------------------- ------------------------------------------------------------ ------------EN-SAVAGPSVAHEAIAECGRAN---SYGDS----------------- ----------------AS------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NPQS------------------- ---------------------------------------------------------LLD LPPELLVEVFSSLPGTELPNLALVCKKFRQILNTETIW-------------------RRR CT---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMREDLRKMEVV-GVSSRELYAKRVNPRVKSGRFMKLLP--DYEHMDYRDVYRHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWESNKVAVE-----------CMYG -HKGPHKGDIQTGKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PRMPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGPCARATKLTGDPNVPAGQLTLDVDLNRPVCLPDLEHQRS MEELSRLVLGVHEEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------V--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----QSPD--------------VAPQG-AASEGAVAGGAGAAGLELAME----------- ------------AQSESP-----QPGP--------------------------------- --------------SS-SSSAP-------------------------------------- -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVMTRNEIYPR----TCKMCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDEDHFGFIWLE LKSFSLYSRLTDRLAHAYAPDM------------ERF-----------------EAMLRN MQS-WTS >ENSPNAP00000037294 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHGQH------------------- ------------------DQHGSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEMD--- ----------------MDEEEGEKIV---------------------------------- ----------------------------------GE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TR------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GSGS------------- ------------------------GGGWPQ------------------------------ ----------SRA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TGPSEA--------------------------- ------------------------------------------------------------ --------------------------------------------AAASAGT--------- ------------------------------------QSPQS------------------- ---------------------------------------------------------LLD LPPELLVEIFSTLPGIALPNLALVCKKFRQILSTETIW-------------------RRR CI---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKDDLRKMEVV-GVSSRELYVKRVNPRVKSGRFMKLLP--DYEHMDYRDVYTHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWERNKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PCLPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIIMLSFHGSRAKATKLTGDPNVPAGQLTLDIDLSHSVQLPDLEHQRS IEELSRLVMGVHEEVQRGSQG---------------------------PAAASA------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------N-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------A---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EEGSSGAEGSDATPACDAEAGEAGA GAASSSP----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------E--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFILPLGVMARNEVYPR----TCKMCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDDDRFGFIWLE LKSFSLYSRLTDQLEHAQAPSM------------ERF-----------------EAMLRN MQS-WTS >ENSAMXP00005023419 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RH---------------------- ------------------DQHGSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEMD--- ----------------MDEEEGERIV---------------------------------- ----------------------------------GE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---ARGG----------------------------------------------------- ------------------------------------------------------------ -------------------WHQSRTAGPSEAAT--------------------------- --------------------------------------AARVAG---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SPQS------------------- ---------------------------------------------------------LVD LPPELLVEIFSSLPGTVLPNLALVCKKFRQILSTETIW-------------------RRR CT---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMRDDLRKMEVM-GVSSRELYVKRVNPRVKSGRFMKLLP--DYEHMDYRDVYAHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWESKKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PCLPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIIMLSFHGSRAKATKLTGDPNVPAGQLTLDIDLSRPVQLPDLEHQRS IEELSRLVMGVHEEVQRGSQD---------------------------PAAASAEAEECS TGAEGSENTP-----------------------------ADEAEEAGAGATSSRT----- --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------Q----------------- -----------------------PFVLPLGVMARNEVYPR----TCKMCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDDDRFGFIWLE LKSFSLYSRLTDQLEHAQAPNM------------ERF-----------------EAMLRN MQS-WTS >ENSEEEP00000046312 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRG-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RSGQH------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPES----------------DSD TDMDGEEEEKIVGEMEACQKTYAAGPGSTNDAGRADERATGLGCGDTACARPSKPRALLD LPPELLVEIFSSLPGTALPNLALVCKKFRQILSTETIW-------------------RRR CT---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKDDLRKMEVL-GVSSRELYVKRVNPRVKSGRFMKLLP--DYEHMDYRDAYIHLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWESNRATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-DEEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PCLSSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIIMLSFHGSRAKATKLTGDPNVPAGQLTLDVDLSRPVRLPDLEHQRN IEELSRLVMSVHEEVQR------------------------------------------- ------------------------------------------------------AAPGPD APPAGADEVSSGAEGSDVSPVAEAEDARGGATTSGPPLE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------Q----------------- -----------------------PFILPLGVMARNEVYPR----TCKMCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDGDRFGFVWLE LKSFSLYSRLTDQLEHAQAPSL------------ERF-----------------EAMLRN MQS-WTS >ENSDARP00000084075 ------------------------------------------------------------ ------------------------------------------------------------ ----------M-----------------------------------LL------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------RM--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHSQA------------------- ------------------DQ-DSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MEMEEGE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EEERVVGKAKDEPDGSGIGGGCHSSCGAGPS GAGSGASASGS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HPQS------------------- ---------------------------------------------------------LLD LPPELLVEIFASLPGIALPNLALVCKKFRQILNTETIW-------------------RRR CT---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMRDDLRKMEIV-GISSRDLYVK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWEKNKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PCLPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIIMLSFHGSKAKATKLTGDPNVPAGQLTLEIDLQRPVRLPDLEQQRS MEELSRLVLGVHEEIQRASQSQGVQAEAAESEVEASDSAPPAGAEDEEPAAA-------- ------------------------------------------------------AAP--- --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------Q----------------- -----------------------AFVLPLGVMARNEVYPR----TCKMCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDDDRFGFIWLE LKSFSLYSRLTDQLTHAQAPSM------------QRF-----------------ENMLRN MQS-WTS >ENSDCDP00000055325 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHREQ------------------- ---------------------GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEAD--- ----------------MDEEE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EEERIVGK----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PKADAGCHDGSGAADRLEDPG--------- ------------------------------------------------------------ -----------------------------C---------AGRRRR--------------- -------------------------------------HPQS------------------- ---------------------------------------------------------LLD LPPELLVEIFASLPGTALPSLALVCKKFRQILSTETIW-------------------RRR CT---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKLELV-GVSSREIYVKRVNPRVKSGRFTKLLP--DYEHMDYRDVYARLL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDTMRKRPLFRIHMWESSKATVE-----------CMYG -HRGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PCLPTDLLPPGLFK-------------------------------- ---GTYGSHGL-EIIMLSFHGPCAKATKLTGDPNVPAGQLTLDIDLRRPVCLPDLDSQRN VEELSRLVLGVHEQAQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------A--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------QGPCPPTERAEACDRPEA AASAAPSASQASSSLSGTSPSLHPFILPLGVIARNEEYPR----TCKLCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDDNRFGFIWLE LKSFSLYSRVTDRLAHAHAPTM------------ERF-----------------EAMLQN MQS-WTS >ENSCHAP00000043899 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RPSHQ------------------- ------------------DQ-GSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SDSD--- ----------------MDEEEEEKIV---------------------------------- ----------------------------------GK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LKAEAGKDCQ ESLGAVRPMLELDASAKPCSTNVNRLGYEETNCAVRQKPQS------------------- ---------------------------------------------------------LLD LPPELLVEIFSSLPGTALPNLALVCKKFRQILNTETIW-------------------RRR CT---------------------------------------------------------- ---------------K-------------------------------------------- -----------------------------------------------------------E FGMKEDLRKMELV-GVSSRELYVKRVSPRVKSGRFMKLLP--DYEHMDYRDVYARLL--- -----------------------------HPFRNILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHMWESNRASVE-----------CMYG -HKGPHKGDVQIVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PHLPSDLLRPGLFK-------------------------------- ---GTYGSHGL-EIIMLSFHGSSAKATKLTGDPNVPAGQLTLVVHLNRPVRLPDLERQCT VEDLSRLVLGHHEEMQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AQGEEAQ--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GQGAEGDEGTAAAE------APAVEASTTSGATRAARAA---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SD--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AQ----------------- -----------------------PFVLPLGVIARNEEYPR----SCTKCFYG---TGLIA --------------------GHGFTSPERT------------PGLFILFDENRFGFIWLE LKSFSLYSRLTDPLAQALAPSM------------ESF-----------------EVMLQN MQS-WTS >ENSGMOP00000008682 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHGGQ------------------- ------------------DQPVSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SDVD--- ----------------MDDEEDERIV---------------------------------- ----------------------------------GQ------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------NA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GP------------------------------------- -----------------------------LG----------------------------- ---------------------------------------------------------RAI ------------------------------------------------------------ ---------------------------TGPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NPQS------------------- ---------------------------------------------------------LLD LPPELLVEIFSLLPGTALPTVALVCKQFKQILNTETIW-------------------RRR CA---------------------------------------------------------- ---------------A-------------------------------------------- -----------------------------------------------------------E FGVNEDLRKMEVG-GVSSRDFYVK-------------------------------LL--- -----------------------------HPYKSVLGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-EG-LFVVGWMYLPPHDPRVEDPMRRRPLFRITMSEDRKASVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EDIFHEHTQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PLLPTDLLRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGASARATKLTGDPNVPAGQLTLEVDLSRPVVLPDLERQRS IEELSRLVLGVHAEVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GP---APAACRGSPGGAVGVASGGPPEGVGGGRGG SEASGGAEASGASRGS-SAPSP-------------------------------------- -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFILPLGVMARNEVYPR----TCKKCFYG---TGQIA --------------------GHGFTSPERT------------PGLFVLFDKDRFGFIWLE LKSFSMYSRLTDRLGHAHSPDM------------ECF-----------------EAMLRN MQS-WTS >ENSLOCP00000004146 ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------V------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------RM--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------REDPA------------------- ------------------DQ-DTD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------T--DP-- -------------ELEMDEEEEERIV---------------------------------- ----------------------------------GK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MQAEAGPRC------------------- ------------------------P----------GDGAAR------------------- ------------------------------------------------------------ ---------------------GP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GVTSDPGAAAAPVRAAAGPTRLSCQPQAC--------- ---------------------------KGPG----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SPNS------------------- ---------------------------------------------------------LLD LPPELLVEIFASLPGTTLPNLALVCKKFRHILNTETIW-------------------RRR CT---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMLEDLRKVEVV-GMSSRELYVK-------------------------------LL--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVDDPMRRRPLFRIHMWENNKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-EEEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PPQPSDLLRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHSNSAKGTKLTGDPNVPAGQLTLDIDLSRPIQLPDLEKQRS VEELSRLVMGEHEQVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RAQGEE----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------GP--------------------------------- ---------------------------------------------------------QAG RGRREQGAEGGAGGGDPGDEPPPAEGGAVPQVPSGRG------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------PQ----------------- -----------------------PFVLPLGVMARTEVYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGMFVLFDDDRFGFIWLE LKSFSLYSRITDRLPYAQAPSL------------KAF-----------------EEMLKN MQS-WTS >ENSSFOP00015023004 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AAC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RQSQQ------------------- ------------------DK-DSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIV---------------------------------- ----------------------------------GR------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------VRIEAAP--------------------- ------------------------------------------------------------ ----------------------------------------------------------P- ---------------------GP------------------------------------- --------------------------------------------TGPADLGTVDITANDH RVWCGSTATGSPEQ---------------------------------------------- ------------------------------------------------------------ -----------------------------PS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NPQS------------------- ---------------------------------------------------------LVE LPPELLVEIFALLPGAALPNLALVCKKFRQILNTETIW-------------------RRR CA---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMKGEPRKMEEV-GVSSRELYAKRVNLRMESRRFIKVLP--DNERTDFRSLYTQML--- -----------------------------HPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-EG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIHLLDGSKATVE-----------CMYG -HKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PRLPSDLLEPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTRARGTKLTGDPNVPAGQLTLDVDLSCPVCLPDLDSQKS MDVLSRLVQEVHEQVQRG----------------------------------------C- --------TPRSPTCHTEAGAEQNERPGAASASGSGVTTA-------------------- --------------------------------------DP-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------PS------------------------------------- --------------------------------------------------------E--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LQ----------------- -----------------------PFVLPLGVMARNEVYPR----TCKMCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDDDRFGFIWLE LKSFSLYSRLTDNLPYAQAPSV------------ERF-----------------EEMLRS MQS-WTS >ENSPKIP00000035974 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AAC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RHSQQ------------------- ------------------DQ-DSD------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S--D--- ----------------MDEEEEERIVCNTQAEAAAGHPDTRLSASGPAVVGDLGTVT--- ---------------AGANANRHSV----GSSGSG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------EQ---------------------------------------------- ------------------------------------------------------------ -----------------------------P------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NSQS------------------- ---------------------------------------------------------LVE LPPELLVEIFGLLPGTALPNLALVCKKFRQILNTETIW-------------------RRR CI---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGLKGDPCMMEQV-GVSSWELYTRRVHPSMASRRYVKVLP--DCERTDYRKLYTRIL--- -----------------------------HPYRHVLGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVEDPMRRRPLFRIRMLGEDKAAVE-----------CMYG -HRGPHRGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PRQPSDLLQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGPWARGTKLTGDPNVPAGQLTLDVDLSRPVHLPDLESQWS MDELSRLVLAVHEQVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------DA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------PSDPSSLDVELGAGGKEGQMSGASAQGSEVPPAGAP--- -------------------------------------------------------QE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------RQ----------------- -----------------------NFVLPLGVMARNEVYPR----TCKMCFYG---TGLIA --------------------GHGFTSPERT------------PGLFVLFDDDRFGFIWLE LKSFSLYSRLTDSLPYAQAPSM------------ERF-----------------EDMLRS MQS-WTS >ENSECRP00000010475 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRRC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RQQRG------------------- ------------------DP---------------------------------------- ------------------------------------------------------------ --------------------------------------------------------DSNP GLELDDDDDEEENEGVMD----ERIV---------------------------------- ------------------------IKRQDASKASGK------------------------ ------------------------------------------------------------ ---------------------------------------------------AVVSTAPVT SASSTSAILNGLSNRNPEHK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GSP------------------------------------- -----------------------------------R------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LLD LPPELLVEIFSSLPGTALPNLSLVCKKFRQIINTDTIW-------------------RRR CI---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGMCEDLRKLEVE-GLPSRELYVK-------------------------------LL--- -----------------------------YPYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPRVNDPMRRRPLFRIHMWESSKATVE-----------CMYG -YKGPHKGDIQTVKKDEFSTKCNQTDHHRMPGGRQ---------EEFRTWL-EEEWGRTL --------------------EDIFHEHMQELILMKFIYTCQYD----------------- -NCLTYHRIYLP--PHHPGDVMKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHVNRAKGTKLTGDPNVPAGQLTLDIDLSRTIQLPDIDKQRS IDELSRLVMEVHEQVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- -------------------------------------------------QQLAQREDADI GNENSRAPLASANIPLMNGSQDVEEDDHVENEMEQPLHEEAA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------AHH--------------QE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPGGVMARNEVYPR----TYRMCFYG---TGLIA --------------------GHGFTSPERT------------PGIFILFDDDCFGFIWLE LKSFSLYSRVKDTLQYAEAPSA------------EAF-----------------EEMLKN MQS-WTS >ENSHGLP00100016806 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRGGPA------------------E-- ------------T--TAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SELD--- --------------------------------------------------------TDP- -EEERIEA-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------P------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------S-PP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLD LPPELLVEIFASLPGTDLPSLAQVCSKFRRVLHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKMEIT-GLSCRDIYAKRVNPHVKSGRFMRILP--DYKHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGHRARGTKITGDPNIPAGQQTVEVDLRHRIQLPDIENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------EPSEGPA-------- --------------------LPQEQAAREADA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------APAEDSRKPADGAAAA EQL------AQ---------------------------SGKGQ----------------- -----------------------PFVLPMGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFLLFDEDRFGFIWLE LKSFSLYSRVRASFRHADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSHGLP00000018843 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRGGPA------------------E-- ------------T--TAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SELD--- --------------------------------------------------------TDP- -EEERIEA-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------P------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------S-PP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLD LPPELLVEIFASLPGTDLPSLAQVCSKFRRVLHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKMEIT-GLSCRDIYAKRVNPHVKSGRFMRILP--DYKHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKLATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGHRARGTKITGDPNIPAGQQTVEVDLRHRIQLPDIENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------EPSEGPA-------- --------------------LPQEQAAREADA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------APAEDSRKPADGAAAA EQL------AQ---------------------------SGKGQ----------------- -----------------------PFVLPMGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFLLFDEDRFGFIWLE LKSFSLYSRVRASFRHADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSCLAP00000000922 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQVVKKDEFSTKCNQTDHHRMAGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPGDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGHRARGTKITGDPNIPAGQQTVEIDLRYRIPLPDVENLRN FNELSRIVLEVGEQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------EADEGPA-------- --------------------LAQEQPAREAEA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------VPAEDSRKPEDGAAAA EQA------AQ---------------------------SGKGQ----------------- -----------------------PFVLPMGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFIWLE LKSFSLYSRVQAAFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSCPOP00000015598 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRGGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------P------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLD LPPELLVEIFGSLPGTDLPSLAQVCSKFRRVLHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGHHARGTKITGDPNIPAGQQTVEIDLRYRIQLPDVENLRN FNELSRIVLEVGEQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------EAGEGPS-------- --------------------QAQDPPPREADT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------VPAEGSGKPADGEAAA EQP------AQ---------------------------SGKGQ----------------- -----------------------PFVLPMGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFIWLE LKSFSLYSRVRAAFRNADAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSFDAP00000011164 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ YGVSENLRKMEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKQDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGHRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDVENLRN FNELSRIVLEVREQLRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------EVAEGPA-------- --------------------LPEEQPAREADT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------VPAGDSWKPAAGVAAA EQQ------AQ---------------------------SGKGQ----------------- -----------------------PFVLPMGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFIWLE LKSFSLYSRVRASFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSCAPP00000003815 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------ALVPGLVLHPVTQEGPR---------------------ALFPSLV HSLPGICCDLASVL---------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGHHARGTKITGDPNIPAGQQTVEIDLRYRIQLPDVENLRN FNELSRIVLEVGEQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------EAGEGPS-------- --------------------QAQDPPPREADT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------VPAEGSGKPADGEAAA EQP------AQ---------------------------SGKGQ----------------- -----------------------PFVLPMGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFIWLE LKSFSLYSRVRAAFRNADAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSODEP00000004676 GKRCLGARVRSLGKLGPDLPPPGLHLSLPPCHSPVCLCGFVMSDL--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------L--------------RVC ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGHRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDVENLRN FNELSRIVLEVGEQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------R------------------------EAGEDPV-------- --------------------LAQEQPAREAEAGPGEDGGGKPS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------DG---------ADGAAAA EQP------DQ---------------------------SSKGQ----------------- -----------------------PFVLPMGVSSRNEDYPR----SCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFIWLE LKSFSLYSRVQAAFRNADAPSL------------QAF-----------------DEMLKN IQS-LTS >ENSCGRP00015029380 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEAD--- --------------------------------------------------------TDP- -EEERIEA-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------P------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLHRRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E-------------------------AGEDPAPLREPSAK GPDGPHAADSKEPG-SGAE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAEPSASSGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQATFQNADAPSP------------QAF-----------------DEMLRN IQS-LTS >ENSCGRP00001002420 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEAD--- --------------------------------------------------------TDP- -EEERIEA-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------P------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLHRRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E-------------------------AGEDPAPLREPSAK GPDGPHAADSKEPG-SGAE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAEPSASSGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQATFQNADAPSP------------QAF-----------------DEMLRN IQS-LTS >ENSCGRP00000021383 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------A-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------P------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLHRRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E-------------------------AGEDPAPLREPSAK GPDGPHAADSKEPG-SGAE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAEPSASSGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQATFQNADAPSP------------QAF-----------------DEMLRN IQS-LTS >ENSMAUP00000011656 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEAD--- --------------------------------------------------------TDP- -EEERIEA-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------P------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLHRRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E-------------------------AGEDPAPPREPSAK GPDGPHAGDSKEPG-SGAE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAEQSASSGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQATFQNADAPSP------------QAF-----------------DEMLRN IQS-LTS >ENSMOCP00000007258 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEAD--- --------------------------------------------------------TDP- -EEERIEA-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------P------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLHRRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E-------------------------AGEDPAPPREPSAK GPDGPPAEGSREPG-SGAE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAGQSASSGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQATFQNADAPSP------------QAF-----------------DEMLRN IQS-LTS >ENSPEMP00000010157 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEAD--- --------------------------------------------------------TDP- -EEERIEA-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------P------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------T------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLHRRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E-------------------------AGEDPAPPREPSAK GPEGPPAGDSKEAG-SGAEAA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AAA-------------------AAEQSASTGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQATFQNADAPSP------------QAF-----------------DEMLRN IQS-LTS >ENSMSIP00000019117 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEAD--- --------------------------------------------------------TDP- -EEERIEA-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------P------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLQRRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------Q----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E-------------------------AGEGPAPPREPSAK AADGPPAKDGKEPG-GGAE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAEQSASSGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQATFQNAAAPSP------------QAF-----------------DEMLRN IQS-LTS >ENSMUSP00000057573 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEAD--- --------------------------------------------------------TDP- -EEERIEA-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------P------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLQRRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------Q----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E-------------------------AGEGAAPPREPSAK AADGPPAKDGKEPG-GGAE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAEQSASSGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQATFQNAAAPSP------------QAF-----------------DEMLRN IQS-LTS >MGP_SPRETEiJ_P0089817 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEAD--- --------------------------------------------------------TDP- -EEERIEA-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------P------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLQRRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------Q----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E-------------------------AGEGPAPPLEPSAK AADGPPAKDGKEPG-GGAE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAEQSASSGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQATFQNAAAPSP------------QAF-----------------DEMLRN IQS-LTS >MGP_PahariEiJ_P0054547 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEAD--- --------------------------------------------------------TDP- -EEERIEA-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------P------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLQRRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------Q----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E-------------------------AGEGPAPPREPSAK APDGPPAKDSKEPG-SGAE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GAEQSASSGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQATFQNADAPSP------------QAF-----------------DEMLRN IQS-LTS >MGP_CAROLIEiJ_P0086296 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPS------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEAD--- --------------------------------------------------------TDP- -EEERIEA-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------P------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLQRRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------Q----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E-------------------------AGEGPVPPREPSAK APDGLPAKDGKESGHGGAE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAEQSASSGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQATFQNAAAPSP------------QAF-----------------DEMLRN IQS-LTS >ENSMUGP00000009915 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEAD--- --------------------------------------------------------TDP- -EEERIEA-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------P------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRVMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLQRRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E-------------------------AGEGPAPPREPAAK GPAGPPARDSKEPG-GGAE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAEQSGSSGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQATFQNADAPSP------------QAF-----------------DEMLRN IQS-LTS >ENSRNOP00000063581 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEAD--- --------------------------------------------------------TDP- -EEERIEA-G-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------P------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLQRRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------Q----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E-------------------------AGEGPAPHREPAVK DPEGPPAKASKEAG-PGAE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AAEQSSTSGQGQ----------------- -----------------------PFVLPAGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQATFQNADAPSP------------QAF-----------------DEMLRN IQS-LTS >ENSCCNP00000020481 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-GV-AAPAGP----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGP--------------------------------- -------------------GAGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGWRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDVENLRN FNELSRLVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E-------------------------ASEGPA-------- --------------------LPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQ---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PS-----------------AQVPSG---AAA -----------------------------------------------EDSGEPGSGVAAV EQP------AQ---------------------------SGQGQ----------------- -----------------------PFVLPVGVSSRSEDYPR----TCRTCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQAAFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSMNEP00000043319 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-SA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CSGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRLVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGRGQQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESQPSPAQPRVEAPSRGPDGTPGEDSGKPGDASAAA EPP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSCATP00000044398 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-SA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRLVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGRGQQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESQPSPAQPRVEVPSRGPDGTPGEDSGKPGDASAAA EPP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSTGEP00000024316 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-SA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFVKILP--DYEHMAYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRLVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGRGQQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESQPSPAQPRVEAPSRGPDGTPGEDSGKPGDASAAA EPP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSPANP00000007841 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-SA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFVKILP--DYEHMAYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRLVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGRGQQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESQPSPAQPRVEAPSRGPDGTPGEDSGKPGDASAAA EPP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSCSAP00000014905 ------------------------------------------------------------ ------------------------------------------------------------ ----------M------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------ATARGLRGRRPTGRGWCGRGGAPA RGGAGLSRGRGGLCGGAVARRWRGGAALERAQRRRQGPSLGGM--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-SA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFVKILP--DYEHMAYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRLVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGHGQQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESQPSPAQPRVEAPSRGPDGTPGEDSGKPGDASAAA EPP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSMMUP00000061573 ------------------------------------------------------------ ------------------------------------------------------------ ----------M------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------ATARGLRGRRPAGRGWRGRGGAPA RGGAGLSRGRGGLCGGAVARRWRGGAALERAQRRRQWPSLGGM--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-SA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFVKILP--DYEHMAYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRLVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGRGQQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESQPSPAQPRVEAPSRGPDGTPGEDSGKPGDASAAA EPP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSMFAP00000038227 ------------------------------------------------------------ ------------------------------------------------------------ ----------M------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------ATARGLRGRRPAGRGWRGRGGAPA RGGAGLSRGRGGLCGGAVARRWRGGAALERAQRRRQWPSLGGM--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-SA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFVKILP--DYEHMAYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRLVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGRGQQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESQPSPAQPRVEAPSRGPDGTPGEDSGKPGDASAAA EPP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSRBIP00000017219 KRQ-----------------------------------------LPT------------- ---------------------HGQ------------------------------------ ------AGHSF------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------GC-RK------------------R------------------G------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRGGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-SA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRLVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGRSRQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESQPSPAQPRAEAPSRGPDGTPGEDSGEPGDASAAA EQP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSCANP00000019380 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------P------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRLVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGRSRQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESQPSPAQPRAEAPSRGPDGTPGEDSGEPGDASAAA EQP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSRROP00000008159 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRLVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGRSRQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESQPSPAQPRAEAPSRGPDGTPGEDSGEPGDASAAA EQP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSPTEP00000014078 ------------------------------------------------------------ ------------------------------------------------------------ ----------M------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------ATARGLRSHRPAGKWWCGRGGAPA RGGAGLSRGRGGLCGGAVARRRRGGAALERAQRRRQWPSLGGM--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-SA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRLVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGRSRQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESPPSPAQPRAEAPSRGPDGTPGEDSGEPRDASAAA EQP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSGGOP00000009172 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-SA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRIVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGRGRQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESQPSPAQPRAEAPSKGPDGTPGEDGGEPGDAVAAA EQP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSP00000310841 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-S-----AGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRIVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGRGRQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESQPSPAQPRAEAPSKGPDGTPGEDGGEPGDAVAAA EQP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSPTRP00000039253 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-SA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRIVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGRGRQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESQPSPAQPRAEAPSKGPGGTPGEDGGEPGDAVAAA EQP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSPPAP00000040839 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-SA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFVKILP--DYEHMAYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRIVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGRGRQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESQPSPAQPRAEAPSKGPDGTPGEDGGEPGDAVAVA EQP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSPPYP00000008604 ------------------------------------------------------------ ------------------------------------------------------------ ----------M------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAGRGLGGHRPAGRGWRGQGGAPG RGGAGLSRGRGGLCGGGVARRWRGGAALERAHRRRQWPSLGGM--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-SA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRHILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRN FNELSRIVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGHEAGEGRGRQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GPRESQPSPAQPRAEAPSKGPDGTPGEDVGEPGDAVAAA EQP------AQ---------------------------CGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSCJAP00000008141 ------------------------------------------------------------ -----------------------MVAAWGLGGRSWGCGRGGARPSGGRGGLCGEGVAWRW LSGAALA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------RAQKRRHRPSLGGM--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-GA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGM--------------------------------- -------------------CPGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPSP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVNDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHQIQLPDLENQRN FNELSRIVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------EQ-------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGYEAGEGRGRQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GLRESQPSPAQPRAEAPSRGPDGTPAEDGGEPGDAAAVA EQP------AQ---------------------------SGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSCCAP00000030872 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-GA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CTGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVNDPMRFKPLFRIHLMERKAATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHQIQLPDLENQRN FNELSRIVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGYEAGEGRGRQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GLRESQPSPAQPRAEAPSRGPDGTPAEDGGEPGDAVAVA EQP------AQ---------------------------SGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSANAP00000028270 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-GA-AVLAGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGL--------------------------------- -------------------CTGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVNDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHQIQLPDLENQRN FNELSRIVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------EQ-------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGYEAGEGRGRQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GLRESQPSPAQPRAEAPSRGPDGTPAEDGGEPEDAAAVA EQP------AQ---------------------------SGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSPSMP00000011398 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRGGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-GA-ATLAGL----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------DGP--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------A-PP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDVENLRN FNELSRIVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGGREAGEGHGQQDSREPPPPG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GEL---------------------DGAPAEDGGKPGDAAAEA EQP------GQ---------------------------AGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDENRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQA-LTS >ENSOGAP00000021241 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-GE-ATQAGA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGP--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPSP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMRILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLLERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSGPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGQRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDAEGLRD FNELSRIVLEVRERVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EDGREAGGSRGQQGSRELQPPGRGL--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------G------------------------GVPAEDGGEPGDVAAAA EQP------VQ---------------------------SGPGQ----------------- -----------------------PFVLPAGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQVTFRNAEAPSP------------QAF-----------------DEMLKN IQA-LTS >ENSUPAP00010018973 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-GS-APPSGT----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGP--------------------------------- -------------------CAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPSP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMRILP--DYEHMGYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRVHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRCARGTKITGDPNIPAGQQTVEIDLRHRIQLPDVENLRN FNELSRLVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------EQ-------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q-----------------------QQDGEGPAPPQEP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------L SARGPPGAPAEEGGDPRGG-------------------------------------AAAA EQP------AQ---------------------------S--GQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSSTOP00000010925 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-GS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRVHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRCARGTKITGDPNIPAGQQTVEIDLRHRIQLPDVENLRN FNELSRLVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q-----------------------QQDGEGPAPPQEP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------L SARGPPGAPAEEGGDPRGG-------------------------------------AAAA EQP------AQ---------------------------SGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFVWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSOPRP00000014101 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DC-L-IIGWMYLPPHDPHVDDPMRFKPLFRVHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIQPGLFK-------------------------------- ---GTYGSHGL-EVVMLSFHGWLARGTKITGDPNIPAGQQTVEIDLRHRVQLPDIENLRS FNELSRLVLEVREQVRL------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EG-------------------------------------- ----------------------Q-------------------LEGKQ------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------PR---------------PR K----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------AAA EQP------AQ---------------------------SGQGQ----------------- -----------------------PFVLPVGVSSRSEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGLFILFDEDRFGFIWLE LKSFSLYSRVRAAFRNAEAPSP------------QAF-----------------DDMLKS IQA-VSC >ENSJJAP00000023019 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--STA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-GA-A-PAWP----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGP--------------------------------- -------------------EAAG------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPSS------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGPHARGTKITGDPNIPAGQQTVEIDLRYRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------R--------------------------------------- ----------------------------------------------ETGGSPDPPQEPPS FRGPDELPAED------------SEKSSNGAA---------------------------- --------------------------------------------AAEQ------------ ------------------------------------------------------------ ---------------------------------------PAP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP------VT---------------------------SGHGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRLCYYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSBIXP00000008298 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-GS-AALSGA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GDR--------------------------------- -------------------SAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------S-SP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMRILP--DYEHMKYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HRGPHNGHVQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKHARGTKITGDPNIPAGQQTVEIDLRHRIQLPDAESLHD FNELSRVVLEVREQVRK------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------EQEGGPEDAEGLGQ -----------------------------------------QSP---------------- ---------------QPREEPPAEPAQAPGDGGAAAVA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EPP------AQ---------------------------S--GQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFIWLE LKSFSLYSRVQAAFRNADAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSBTAP00000059299 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-GS-AALSGA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GDR--------------------------------- -------------------SAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------S-SP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HRGPHNGHVQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKHARGTKITGDPNIPAGQQTVEIDLRHRIQLPDAESLHD FNELSRVVLEVREQVRK------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------EQEGGPEDAEGLGQ -----------------------------------------QSP---------------- ---------------QPREEPPAEPAQAPGDGGAAAVA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EPP------AQ---------------------------S--GQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFIWLE LKSFSLYSRVQAAFRNADAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSBIXP00005030099 ------------------------------------------------------------ ------------------------------------------------------------ ----------M------------------------------------------------- -----------------------------------------------NPEGRSRRGAFRL RQPKTF---------------RVPSGGLDQAPDRDFGNVLEAWLSCREGRGLESRGGWGG GALVSPP-----------PRGAGLGSLKGRGEQGSPRGGARLPRGAGLRAPGDGDKAPWR GRNKAPWRGVAWSGGAGLSGRAGGARLSGGACARAAA----------------------- ------------------ARR----------------PSVAGM--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-GS-AALSGA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GDR--------------------------------- -------------------SAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------S-SP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HRGPHNGHVQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKHARGTKITGDPNIPAGQQTVEIDLRHRIQLPDAESLHD FNELSRVVLEVREQVRK------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------EQEGGPEDAEGLGQ -----------------------------------------QSP---------------- ---------------QPREEPPAEPAQAPGDGGAAAVA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EPP------AQ---------------------------S--GQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFIWLE LKSFSLYSRVQAAFRNADAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSCHIP00000010183 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEELIEA-GS-AALSGA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------DDR--------------------------------- -------------------SAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------S-SP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMRILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HRGPHNGHVQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKHARGTKITGDPNIPAGQQTVEIDLRHRIQLPDAESLHD FNELSRVVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------K--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------EQEGGPEDAEGLGR -----------------------------------------QSP---------------- ---------------QPCEEPPAEPAQAPGDGGAAAAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EPP------AQ---------------------------SGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFIWLE LKSFSLYSRVQAAFRNADAPSP------------QAF-----------------EEMLKN IQS-FTS >ENSOARP00000012578 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M----------------- ----------GC-SE------------------R-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMRILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HRGPHNGHVQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKHARGTKITGDPNIPAGQQTVEIDLRHRIQLPDAESLHD FNELSRVVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------K--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------EQEGGPEDAEGLGR -----------------------------------------QSP---------------- ---------------QPCEEPPAEPAQAPGDGG--AAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EPP------AQ---------------------------SGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFIWLE LKSFSLYSRVQAAFRNADAPSP------------QAF-----------------EEMLKN IQS-FTS >ENSFCAP00000040029 ------------------------------------------------------------ ------------------------------------------------------------ ----------MLGGIVFPCPVRARDLGVRSRLGRGGLNRS-------------------- -PLGGRGRAAWGRGPSCSRGRGPADRRRVRTGGGGAAAV-------PR------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------AGM--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-GA-AALVGA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGR--------------------------------- -------------------GAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------S-PP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLDIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRVHLMERKSATVE-----------CMYG -HRGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKRARGTKITGDPNIPAGQQTVEIDLMHRIQLPDVESLRS FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QEDGAEDGDGRAP -----------------------------------------QSPREPQRGPAQPSVELPA EK----------GGG-------------PADGEAAAAAAPAP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP------AQ---------------------------SGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFIWLE LKSFSLYSRVRATFRNAEAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSCAFP00020005294 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-G------------------------GA----------------------L- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------S----------------------------------- -------------------GA--PGGR--------------------------------- -------------------GAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P-PP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLDIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRVHLMERKSATVE-----------CMYG -HRGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKCARGTKITGDPNIPAGQQTVEIDLMHRIQLPDVESLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QENGPEDGEGRGQ -----------------------------------------QSPREPQRGPAQPSAELPA EK----------GGE-------------SRDGEAEAAAPPAP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP------AQ---------------------------SGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFIWLE LKSFSLYSRVQATFQNAEAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSAMEP00000019297 ------------------------------------------------------------ ------------------------------------------------------------ ----------L------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGR--------------------------------- -------------------GAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------Q-PP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIF-SLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLDIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRVHLMERKSATVE-----------CMYG -HRGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PGRPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTRARGTKITGDPNIPAGQQTVEIDLMRRIQLPDVESLRN FNELSRIVLEVREQLRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QEDGLGGGEGGGQ -----------------------------------------QSPREPQRGPAQPSVELPP EK----------VGQ-------------PGDGEAAAAAAPAP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP------AQ---------------------------SGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFIWLE LKSFSLYSRVQATFRNAEAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSECAP00000043521 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEECIEA-GA-AALSGA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGR--------------------------------- -------------------SAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------S-PP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVNDPMRFKPLFRIHLMERKSATVE-----------CMYG -HRGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKHARGTKITGDPNIPAGQQTVEIDLMHRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QEDGPEDAEGCSR -----------------------------------------QSPQEPQRGPAQPTVEPPA EK----------GSE-------------PGDGGAAAAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP------VE---------------------------SGQGQ----------------- -----------------------PFVLPLGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFIWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSEASP00005020088 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEECIEA-GA-AALSGA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGR--------------------------------- -------------------SAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------S-PP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRVNPRVKSGRFMGILP--DYEHMEYRDVYACLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVNDPMRFKPLFRIHLMERKSATVE-----------CMYG -HRGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKHARGTKITGDPNIPAGQQTVEIDLMHRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QEDGPEDAEGCSR -----------------------------------------QSPQEPQRGPAQPSVEPPA EK----------GSE-------------PGDGGAAAA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------PFVLPLGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFIWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSSSCP00000066991 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRGPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-GA-ATLCGV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGR--------------------------------- -------------------SAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------S-SP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPNLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-FFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HRGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSRPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGQRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDVESLRD FSELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QEDGPEDTEGRGQ -----------------------------------------QSPREPQLGPAPPCKEPPA KL----------GGE-------------PGDGGAAAEA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQL------AH---------------------------SGQGQ----------------- -----------------------PFVLPAGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFIWLE LKSFSLYSRVQAAFRNADAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSTTRP00000008340 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FCTKSRILHTDTIARCR-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HRGPHNGHVQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKHARGTKITGDPNIPAGQQTVEIDLRHRIHLPDIESLRD FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QEGGPEDAAGLGR -----------------------------------------QSP---------------- ---------------SP-AEPPAE-GQGPGDGGAEAAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EPP------AQ---------------------------SGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFIWLE LKSFSLYSRVQAAFRNADAPSP------------QAF-----------------EEMLKN IQS-LAS >ENSMPUP00000008487 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------FLV A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E YGVCENLRKLDIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRVHLMERKSATVE-----------CMYG -HRGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDVESLRN FSELSRLVLDVRERLRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q ESGL-----------------------------EDGGAGGRQSPREPQQGPAQPGAELPA EKVGEAGGAEAAG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AQ---------------------------PGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFIWLE LKSFSLYSRVQATFRNAEAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSVVUP00000000929 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M----------------- A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -R---------------------------------------------------------- ---------------E-------------------------------------------- -------------ARRRRRGGGSWLLQAVATVAAVTAAAEAPTVATATSLVSLQPAAASE YGVCENLRKLDIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRVHLMERKSATVE-----------CMYG -HRGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKCARGTKITGDPNIPAGQQTVEIDLMHRIQLPDVESLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QENGPEDGEGRGQ -----------------------------------------QSPREPQRGPAQPSAELPA EK----------GRE-------------SRDGEAEAAAPPAP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP------AQ---------------------------SGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFIWLE LKSFSLYSRVQATFQNAEAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSUAMP00000019821 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC AR---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------PAV----WRRRGD-----AGRAARRPAETAAADSRA GKRTLRGDASRRELLGALSGA--LGGR--------------------------------- -------------------GAGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------Q-PP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLDIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRVHLMERKSATVE-----------CMYG -HRGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PGRPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTRARGTKITGDPNIPAGQQTVEIDLMRRIQLPDVESLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QEDGLGGGEGRGQ -----------------------------------------QSPREPQRGSAQPSVEPPP EK----------VGE-------------PGDGEAAAAAAPAP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP------AR---------------------------SGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFIWLE LKSFSLYSRVQATFRNAEAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSLAFP00000011586 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------HRRGPA------------------E-- ------------A--ASA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIEA-GA-A----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LA GSR--------------------------------------------------------- ----------------------P------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GPSA------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRRARGTKITGDPNIPAGQQTVEVDLRHRIQLPEAENLRN FNELSRVVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------R--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QQEG--------- ------------------------------------------------------------ ------------------------------------------------------------ EQEDGQDPASPTGEPPAKGAAAGPAEGTAEGHQEPEGSSGAAAQQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----P----------------------TEP------------------------------ ------------------------------------------------------------ -----------------------------------------GQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDDDRFGFIWLE LKSFSLYSRVKAAFQNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSMLUP00000014201 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRRDPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDL- -EEERIEA-GA-A----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ELCSEW---------------------------- ------------------------SGR--------------------------------- -------------------SSSP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------S-PP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFCRILHNDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HRGPHNGHIQIVKKDEFSTKCNQTEYHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKHARVTKITGDPNIPAGQQTVEIDLMHRIQLPNVENLCN FNELSRIVLEAQEQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------R--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QEDRTEDGEGSGP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PTEVREPGNEGAAPLKEEPVQ---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------FVLPVGVSSRNENYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFIWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSSHAP00000019895 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ CF---------------------------------------------------------- ---------------S-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PRRPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKCAKGTKITGDPNIPAGQQTVEIDLMHRIQLPDVENLRN FNELSRIILEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------Q------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EG-------QEE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -GQSRARPSTREGPP-GPAYQKPEPPMPTPSRAAEGGGETEKGVEASGGVPPAA------ PDPAP----------------------SEA------------------------------ ------------------------------------------------------------ -----------------------------------------GQ----------------- -----------------------PFVLPAGVISRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGIFILFDEDRFGFIWLE LKSFSLYSRIKATFQNAEPPSP------------EAF-----------------DEMLKN IQS-LTT >ENSVURP00010027356 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGGGQSRGG-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRKGPA------------------E-- ------------AAGAAA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIE---------------------------------------------------GA P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------P----------------------------------- ------------------------------------------------------------ ----------------------P------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------A-AP------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILNTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PRRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKCAKGTKITGDPNIPAGQQTVEIDLMHRIQLPDVENLRN FNELSRIILEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------Q------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EG-------QEE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -GQGRARPSTRECPP-GPAHQKPEQPVAAAARGAEGGGGTEKSVEAVGGVSRAA------ PEPAP----------------------SEA------------------------------ ------------------------------------------------------------ -----------------------------------------GQ----------------- -----------------------PFVLPAGVISRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGIFILFDEDRFGFIWLE LKSFSLYSRIKATFQNAEPPSP------------EAF-----------------DEMLKN IQS-LTT >ENSPCIP00000012417 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSRGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRKGSA------------------E-- ------------AAGAAA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIE---------------------------------------------------GA PAMPKPSGACGAAGD---------------------------PGAS-------------- -----------------------------LAT----------------GGP--------- -------------------------------AGAG------------------------- ------------------------GSGG-------------------------------- ------------------------------------------------------------ ---------------------------------------PASA--------SACPQA--- ----------------------PQP----------------------------------- ------------------------------------------------------------ ----------------------P------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------A-AP------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILNTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMRILP--DYEHMGYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PRRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKCAKGTKITGDPNIPAGQQTVEIDLMHRIQLPDVENLRN FNELSRIILEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------EQ-------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------Q------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EG-------QEE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -GQGRARPSARECPP-GPAYQKPEQPVPAPARGAEGGGGTEKSVEAVGGVPRAA------ PEPAP----------------------SEA------------------------------ ------------------------------------------------------------ -----------------------------------------GQ----------------- -----------------------PFVLPAGVISRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGIFILFDEDRFGFIWLE LKSFSLYSRIKATFQNAEPPSP------------EAF-----------------DEMLKN IQS-LTT >ENSMODP00000044030 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQARGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRKGPA------------------E-- ------------AAGAAA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SEPD--- --------------------------------------------------------TDP- -EEERIE---------------------------------------------------GV PVMARPVGACG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------ASGH GGAGDPGAGLAAGGAGSPVSTCPQP----------------------------------- ------------------------------------------------------------ ----------------------P------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------Q-PP------------------AR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLE LPPELLVEIFASLPGTDLPSLAQVCTKFRRILNTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PTRPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKCAKGTKITGDPNIPAGQQTVEIDLMHRIQLPDVENLRN FNELSRIILEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PEG-------QEE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -GPGQAPPSARECPPEPPAYQKPEQPAPAPSWGAEGGGGTEKGLEASGDGPPAA------ PEPAP----------------------SEG------------------------------ ------------------------------------------------------------ -----------------------------------------GQ----------------- -----------------------PFVLPAGVISRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFIWLE LKSFSLYSRIKATFQNAEPPSP------------EAF-----------------DEMLKN IQA-LTT >ENSOANP00000005932 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIFLP--PSNPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKCAKGTKITGDPNIPAGQQTVEIDLMHRIQLPDVENLRN FNELSRIILEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQRDGQE ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AEQGRPRQNSREPQPGPSHQRPEHPARGAEGGR AESRAEAEGGAAAAAKEPGR---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SEA------------------------------ ------------------------------------------------------------ -----------------------------------------GQ----------------- -----------------------PFVLPVGVISRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGIFILFDEDRFGFIWLE LKSFSLYSRIKATFQNAEPPSP------------EAF-----------------DEMLKN IQS-LTT >ENSNGAP00000017144 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------V-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GVQGGVGAPAHPPHPSSPASLPSLPARPPHPSF PASLPGLPAHPLRPPCPSSPPILPGLPAQPPRSSSPPIFPGLPARPPHPSSPASLPGLPA RPPHLSCPAFPPVLPTHPAW------------------PPC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------P YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERQSATVE-----------CMYG -HKGPHSGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYT-EAP----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGPRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDVENLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------EAGEGPASPQEP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------QSARGSDGSLAEDSREPGRGVAAA KQP------AS---------------------------SGQGQ----------------- -----------------------PFVLPVGVSSRNEDYPR----TCRLCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDEDRFGFLWLE LKSFSLYSRVQAAFQNADAPSP------------QAF-----------------DEMLKN IQS-LTS >ENSCPGP00000007146 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------G------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AAREQRRG----------------------- ---------------GAG------------------------------------------ -DSEPDTDTDPEEAGGGGGTEDEEAAERIEGG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------RPAPHPAEAGPAGR--------------- -------------------------------------APLS------------------- ---------------------------------------------------------LLE LPPELLVQIFGSLPGTDLPSLARVCTTFRRILRTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKCATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKKAKGTKITGDPNIPAGQQTVEIDLAHPLQLPDIENLRD FSELSRIVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEQR--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QEEENRSQQAASQPAA KPL-GGEGAEGEETAAGAEGTTQNKA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPMGVISRNEDYPR----TCRICFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVSFQNAEAPSR------------EAF-----------------DEMLKN IQS-LAT >ENSGALP00000069407 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------G------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AAREQRRG----------------------- ---------------GGG------------------------------------------ -DSEPDTDTDPEEAGGGG-------------GASVEDD---------------------- ------ELTERIE----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------CSRPAPHPAEVGPNGR--------------- -------------------------------------APMS------------------- ---------------------------------------------------------LLE LPPELLVQIFGSLPGTDLPSLARVCTTFRRILRTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRKAKGTKITGDPNIPAGQQTVEIDLAHPLQLPDIENLRD FSELSRIVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEQQQ-------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GEDEDRSQQAASSPAA QPQ-GGEGAEVEETAAGAEWATQDKT---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPMGVISRNEDYPR----ACRICFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVSFQNAEAPSR------------EAF-----------------DEMLKN IQS-LAT >ENSCJPP00005018125 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------G------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AAREQRRG----------------------- ---------------GGA------------------------------------------ -DSEPDTDTDPEETGGGG-------------GASVEDD---------------------- ------ELTERIE----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------CAGPAPHPAEVGPNGR--------------- -------------------------------------APLS------------------- ---------------------------------------------------------ILE LPPELLVQIFGSLPGTDLPSLARVCTTFRRILRTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRKAKGTKITGDPNIPAGQQTVEIDLAHPLQLPDIENLRD FSELSRIVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EQQR--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GEDEDRSQQAASSPAA QPQ-GGEGAEGEETAAGAERAAQDKA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPMGVISRNEDYPR----TCRICFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVSFQNAEAPSR------------EAF-----------------DEMLKN IQS-LAT >ENSMGAP00000007506 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRKAKGTKITGDPNIPAGQQTVEIDLAHPLQLPDIENLRD FSELSRIVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEQR--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------REDEDRFQQAASSPAA QPQ-GGEGAEGEETTAVAELAAQDKA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPMGVISRNEDYPR----TCRICFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVSFQNAEAPSR------------EAF-----------------DEMLKN IQS-LAT >ENSPMJP00000018514 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPTRGC-RR------------------R------------------G------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------SAREQRRG----------------------- ---------------AA------------------------------------------- -DSEPDTDTDPEEAGGGGVTEDDEAAERIEGG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------RPLPPSVEAGPAGR--------------- -------------------------------------APLS------------------- ---------------------------------------------------------LLE LPPELLVQIFGSLPGTDLPSLARVCTTFRRILRTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKCATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPNDLIQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGNKAKGTKITGDPNIPAGQQTVEIDLAHPLQLPDIENLRD LSELSRIVLEVQEQIRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------REQR--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QEEEEHSQ----QPAS -PL-AGEGAEGEETAAGAEGKTQDKA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPMGVISRNEDYPR----TCRICFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVSFQNAQAPSR------------EAF-----------------DEMLKN IQS-LAT >ENSLSDP00000024014 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------G------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------SAREQRCG----------------------- ---------------TA------------------------------------------- -DSEPDTDTDPEEAGGGGVTEDDEAAERIEGG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------RPLPPSVVACPAAR--------------- -------------------------------------APLS------------------- ---------------------------------------------------------LLE LPPELLVQIFGSLPGTDLPSLARVCTTFRRILSTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCQDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKCATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPEDLIQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKKAKGTKITGDPNIPAGQQTVEIDLAHPLQLPDIEILRD FSELSRIVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------REQR--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QDEKEHSQQAASQPAS -PL-GGEGAEGEETAAGAEGTTQDKA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPMGVISRNEDYPR----TCRVCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVSFQNAQAPSR------------EAF-----------------DEMLKN IQP-MAT >ENSJHYP00000005649 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------G------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AAREQRRG----------------------- ---------------NA------------------------------------------- -DSEPDTDTDPEEAGGGAVTEDDEAAERIEGG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------RPLPPSVEAGPAGR--------------- -------------------------------------TPLS------------------- ---------------------------------------------------------LLE LPPELLVQIFGSLPGTDLPSLARVCTTFRRILRTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKCATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPQDLIQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKKAKGTKITGDPNIPAGQQTVEIDLAHPLQLPDIETLRD FSELSRMVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------REQR--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QEEQEHSQQAASQPAS -PL-GGEGAEGEETAAGAEGTTQDKA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPTGVISRNEDYPR----TCRVCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVSFQNAQAPSQ------------EAF-----------------DEMLKN IQF-LTT >ENSSCAP00000009006 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RVCTTFRRILSTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKCATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPEDLIQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKKAKGTKITGDPNIPAGQQTVEIDLAHPLQLPDIETLRD FSELSRIVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------REQR--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QEEEEHSQQAASQPAS -PL-GGEGAEGEETAAGAEGRTQDKA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPMGVISRNEDYPR----TCRVCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVSFQNAQAPSR------------EAF-----------------DEMLKN IQS-LAT >ENSFALP00000006880 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GGG----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GRRRSAAREQRRG----------------------- ---------------AA------------------------------------------- -DSEPDTDTDPEEAGGGGVTEDEEGAERIEGG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------RPLPPSVEAGPAGR--------------- -------------------------------------APLS------------------- ---------------------------------------------------------LLE LPPELLVQIFGSLPGTDLPSLARVCTTFRRILRTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPEDLIQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRKAKGTKITGDPNIPAGQQTVEIDLAHPLQLPDIENLRD FSELSRIVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QEQEEHSQQAASQPAS -PL-AGEGAEGEETAAGAEGLTQNKA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPMGVISRNEDYPR----TCRICFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVPFQNAQAPSR------------EAF-----------------DEMLKN IQS-LAT >ENSTGUP00000007817 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------G------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------A------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------VRYLRCVTS---DSE---------------------------------- -------------------------------------PD--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SDS---------------------------------YS EEVE-----------------------SFCGRPLPPS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ LPPELLVQIFGSLPGTDLPSLARVCTTFRRILSTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCQDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKCATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPEDLIQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKKAKGTKITGDPNIPAGQQTVEIDLAHPLQLPDIENLRD FSELSRIVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------REQR--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QEEKEHSQQAASQPAS -PL------RGEETAAGAQGTTQDKA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPMGVISRNEDYPR----TCRVCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVSFQNAQAPSR------------EAF-----------------DEMLKN IQP-LAT >ENSCPUP00000013651 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TPNLIWLQCLLCEVCILPIL--------------- ------------------------------------WP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKCATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRKAKGTKITGDPNIPAGQQTVEIDLAHPLQLPDIENLRD FSELSRIVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEQR--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QEEEDRSQQAASQSAA KPL-GGEGAEGEETAAGAEGTTQSKA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPMGVISRNEDYPR----TCRICFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVSFQNAEAPSR------------EAF-----------------DEMLKN IQS-LAT >ENSAPLP00000026204 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------A-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------TSEHPAMLFLSDTLPW LPQSTLPCSLSETPAMAASECPTMFFCDTP-----PWPPQ-------------------- -------------SAPCCSSATHHHVPLQLHPAMAASVSLHVPLQR-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------RPAMATSWCP STSPPSNTQLQSPQKQSALFVYQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKCATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRKAKGTKITGDPNIPAGQQTVEIDLAHPLRLPDIENLRD FSELSRIVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEQR--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QEGEDRSQQAASQPAA QPQGGGEGAEGEETAAGAEGAAQDKA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPMGVISRNEDYPR----TCRVCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVSFQNAEAPSR------------EAF-----------------DEMLRN IQS-LAT >ENSABRP00000025665 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------S-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PLSNTPPWPPQGVPPCPLSATHHHGHLRVSH HVPPQRHTTMATSE---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------CP TTSPLSNAQLQPPRRQSAMFVYQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKCATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRKAKGTKITGDPNIPAGQQTVEIDLAHPLRLPDIENLRD FSELSRIVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEQR--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QEGEDRSQQAASQPAA QPLGGGEGAEGEETAAGAQGAAQDQA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPMGVISRNEDYPR----TCRVCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVSFQNAEAPSR------------EAF-----------------DEMLKN IQS-LAT >ENSDNVP00000006498 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RWSYCPNNLTLFFGDRLLSSILMLLL------------------TLFLVFPLMYQFPPL SKGVCRARWTAASIER-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKCATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHTQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKKAKGTKITGDPNIPAGQQTVEIDLAHPLQLPDIENLRD FSELSRIVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEQR--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QEEEDCSQQAASQPAA QAL-GGEGAKGEETAAGAEGAAQDKA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPMGVISRNEDYPR----TCRICFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVSFQNAEAPSR------------EAF-----------------DEMLKN IQS-LAT >ENSCCEP00000006751 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ALQESA GILPQPLAVFGEGQCVCCVPCPPHLRCPCLSQSVQDVGSLEKENTNQVSVADVKTLAPNI FVPGLTLFSC-------------------------------------------------- ----------------------VVA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKCATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPGDLIQPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGNKAKGTKITGDPNIPAGQQTVEIDLAHPLQLPDIENLRD FSELSRIVLEVQEQIRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------REQR--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QEEEEHSQQPAS---- -PL-GGEGAEGEETAAGAEGKTQDKA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPMGVISRNEDYPR----TCRICFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVSFQNAQAPSR------------EAF-----------------DEMLKN IQS-LAT >ENSNMEP00000000395 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------S-- ------------------------------------------------------------ ------------------------------------------------------------ ---------ASVTSLRGVFLRWDCCRHGLENTGFPTCSAVTSSFSFALQQSSKILRLMAQ LGTISKDRGWQGLSTRADVVIRVVA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGRKAKGTKITGDPNIPAGQQTVEIDLAHPLQLPDVENLRD FSELSRIVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------DEQQ--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QGEEDRSQQAASSPAA QPQ-GGEGAEGEETAAGAERATQDKA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPMGVISRNEDYPR----TCRICFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDDRFGFIWLE LKSFSLYSRIKVSFQNAEAPSR------------EAF-----------------DEMLKN IQS-LAT >ENSGAGP00000017489 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PAP------------------------- -------------------------------------APLS------------------- ---------------------------------------------------------LLE LPPELLVQIFGFLPGTDLPSLARVCSTFRRIL---------------------------- -R---------------------------------------------------------- ---------------X-------------------------------------------- -----------------------------------------------------------S YGVCENLRKLEIT-GVSCRDVYAKRINPRVRSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-FFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSNADDLLKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKKAKGTKITGDPNIPAGQQTVEIDLAHPIQLPDIENLCN FNELSRIVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEG--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QEEEE----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------GHSR QG---------------------------------------------------------- -----------------------------------------------------DSQQV-- ------------------------------------------------------------ EQP------VQRDDAEAEGTEAAGVAATQESAL-------TLQ----------------- -----------------------PFVLPVGVISRNKDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGIFILFDDDRFGFIWLE LKSFSLYSRIKVSFQNAEAPSR------------EAF-----------------DEMLKN IQS-MTT >ENSCABP00000006384 ----------------------------------------------EVFREGKLYPGALW TSKNLFTQSLILLPLNPFLSVT-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TE----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRVHLMERKSATVE-----------CMYG -HKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSNADDLLKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKKAKGTKITGDPNIPAGQQTVEIDLAHPIQLPDIENLHN FNELSRIVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------E--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEG--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QDEEE----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------GRSQ QG---------------------------------------------------------- -----------------------------------------------------DSQQV-- ------------------------------------------------------------ EQP------AQRDDAGAEGTEAAGAAAAQESAL-------TSQ----------------- -----------------------PFVLPVGVISRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGIFILFDDDRFGFIWLE LKSFSLYSRIKVSFQNAEAPSR------------EAF-----------------DEMLKN IQS-MTT >ENSCPRP00005009546 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGAGTARGC-RR------------------R------------------G------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------A------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------RPGP------------------------- -------------------------------------A-RS------------------- ---------------------------------------------------------LLE LPPELLVHIFGYLPGPDLPCLAQVCGAFRRLLRTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-FFIIGWMYLPPHDPHVDDPMRFKPLFRVHLMERTSATVE-----------CMYG -HKGPHSGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSSPNDLIKPGLFK-------------------------------- ---GTYGSHGL-EIIMLSFHGKKAKGTKITGDPNIPAGQQTVEIDLLHPIQLPDIENQHN FNELSRIILEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ---QQ QE---------------------------------EEEG--------------------- -----------------AGCSRQSTTPQAEQPAQEGDAGAEETADRA------------- ------------------GAAAQGSEPA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SQ----------------- -----------------------PFVLPPGVISRNKDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGAFVLFDDDRFGFIWLE LKSFSLYSRIKVAFQNAEAPSQ------------EAF-----------------EEMLKN IQS-LAT >ENSACAP00000014300 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPVRGC-RR------------------R------------------G------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------A------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QRKGTSGDSSEPD--- --------------------------------------------------------TDP- -EE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------GGGC-----DGG---------------- ------GGGGEEASEDEAREERIEG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PT------------------PR--------- ------------------------------------------------------------ --------------------------------------------R--------------- -------------------------------------APLS------------------- ---------------------------------------------------------LLE LPPELLVQIFGSLPGPDLPSLARVCTAFHRLLRTDTIW-------------------RRR CK---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAKRINPRVKSGRFMKILP--DYEHMEYRDVYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHSGHIQIVKRDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PQSPDDLIEPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKKAKGTKITGDPNIPAGQQTVEIDLAHPIRLPDIESLSN FSELSRIVLEVEERVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ---QQ QQ---------------------------------EEEGVQGEKGQEEVLQPGAAVPEGD GAEAPEEEEGAVAAQTPSPC---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------PFVLPGGIASRNEDYPR----TCRACFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDNDRFGFIWLE LQSFSLYSRIKVSFQNAEAPSQ------------DAF-----------------DEMLKN IQL-LTS >ENSPVIP00000015777 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------VCRAFRRLLRTDTIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHSGHVQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PQSSEDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKKAKGTKITGDPNIPAGQQTVEIDLAHPIQLPDIENLSN FSELSRLVLEVQQQVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------RRQDAEEEG--------------------- ----------------------------------------------AAQEGQAPPHEEPQ LEVPCPGRGGEGLAVDEPGSAAQGSP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------PC----------------- -----------------------PFVLPGGIASRNEDYPR----TCRACFYG---MGLIA --------------------GHGFTSPEQT------------PGVFVLFDEDRFGFIWLE LQSFSLYSRIKVAFQNADPPSR------------EAF-----------------DEMLKN LQL-LTS >ENSSMRP00000008360 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGPARGC-RR------------------R------------------G------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------A------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QRKGAAGDSSEPD--- --------------------------------------------------------TDP- -EE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------GGG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---GGCEASGDATVVSAEAAATAWSEGA-------------PRGR--------------- -------------------------------------APLS------------------- ---------------------------------------------------------LLE LPPELLVQIFGSLPGTDLPNLALVCSAFRRLLRTDTIW-------------------RRR CK---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKSATVE-----------CMYG -HKGPHSGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYVP--PRSADDLIEPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGKKAKGTKITGDPNIPAGQQTVEIDLAHPIQLPDIENLSN FSELSRLVLEVQEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ---QQ EEKGQEDEPPPPPEPSPQGEDDTEAPGAAE------------------------------ ------------------------------------------------------------ ------------------GAAAQGSP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SY----------------- -----------------------PFVLPSGIASRNEDYPR----TCRACFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDDNRFGFIWLE LQSFSLYSRIKDSFQNAEAPSP------------EAF-----------------DEMLKN IQL-LTS >ENSDORP00000002827 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------PLQPSLRTALLSP----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------RGC-RR------------------R-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LRSWGGPVQALFQNGSRG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------C------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------RGPSPTPVSVWFSGVGTHVFLVA------ -----------------------------------------------------------E YGVCENPRRLESP-GVSFRHVYAQ-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIVGWMYLPPHDPHVDDPMRSKPLFRIHLMERRSATVE-----------CMYG -HKGPHNGHVQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-KEEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PSHPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGQYARGTKITGDPNIPAGQQTVEIDLRHRIQLPDVENLCN FNELSRIVLEVHEQVRR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q------------------------EAGDGPAPPREQ--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------LAARGPDGAAAQDSKEPGD----- --------------------EAA------------SAPAGQGQ----------------- -----------------------PFVLPVGVSSRNEKYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFVLFDENRFGFLWLE LKSFSLYSRVQATFRNADAPSP------------QAF-----------------DEMLKN IQS-LSS >ENSUMAP00000010379 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------KNHTHFLCHIIYSDA CAHLSPGCHSSRVPESPPSPPGKEPREAEL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------C------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------LLGFPAVGREREKTSNPLPPT-------------- ---------------E----------TDQ------------------------------- -----------------------------------------------------------K YGVCENLRKLDIT-GVSCRDVYAK-------------------------------LL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDPMRFKPLFRVHLMERKSATVE-----------CMYG -HRGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQ---------EEFRTWL-REEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--PGRPDDLIRPGLFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTRARGTKITGDPNIPAGQQTVEIDLMRRIQLPDVESLRN FNELSRIVLEVREQVRQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QEDG--------- ---LGGEXXXXXXXXXXXXXXXXXXXXXXXXXXX-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------PFVLPVGVSSRNEDYPR----TCRMCFYG---TGLIA --------------------GHGFTSPERT------------PGVFILFDEDRFGFIWLE LKSFSLYSRVQATFRNAEAPSP------------QAF-----------------EEMLKN IQS-LTS >ENSXETP00000045366 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AVC ARLCGVGQSGGC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRKG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AGNGPELEDEEEEDEVRIEAEVIGGQAAEAP----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------R--------------- -------------------------------------RPRS------------------- ---------------------------------------------------------LLH LPPEILVEIFSSLPGTELPSLAQVCRKFRQILTTDTIW-------------------KRR CK---------------------------------------------------------- ---------------Q-------------------------------------------- -----------------------------------------------------------E YGVCENLRKLEVT-GVSCRDVYVKRINPRVKSGRFMKILP--DYEHMEYRDIYTCLL--- -----------------------------HQYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDEAMRLKPVFRIHLMERNDATVE-----------CMYG -HKGPHNGQIQIVKKDEFSTKCIQTDYHRMSGGRQ---------EEFRTWL-REDLGRTL --------------------EDIFHEHMQELILMKFIYICQYD----------------- -NCLTYRRIYHP--PSRPDDLLNPGFFK-------------------------------- ---GTYGSHGL-EIVMLSFHGTIAKVTKITGDPNVPAGQQTLEVDLTRPVQLPDVEHLRN FDEMSRLILDVQAQIHR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QR----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ---------------TGNE----------------------------------------- ---------EDDGRGAGPDKAEHSQQ---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------PAPVLRPANEDANKVDGGDGE EQ---------------------------------------------------------- ------------------------KP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PN--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VQ----------------- -----------------------SFVLPTGVMARNEEYPR----SCKMCFYG---TGLIA --------------------GHGFSSPERT------------PGLFILFDEDRFGFIWLE LKSFSLYSRMRDRFQQSEAPSV------------EAF-----------------EEMLQN MQS-WTT >ENSLACP00000010901 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AMC ARLCGVGQSRSC-RR------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------Q-------------------------- ------------------------------------------------------------ -------------------------------------QQQQRDADPEVEEHIVSRMPAAA AAEAEAETT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TDP- -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------ADGNGRIVTS-------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PP------------------PT--------- ------------------------TTSGRGGGEPGGAAGATTAGYQVPPEAGTEPPTLH- ------------------------------------------------------------ ----------------------------------------R------------------- ---------------------------------------------------------LLD LPPELLVEIFASLPGTELPSLSLVCKKFRQILNTDTIW-------------------RRR CG---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCDNLRKLESV-GASCQDLYIKRVDPRVRSGRFVKVLP--DYNHTEYQDIYTCLL--- -----------------------------HRYRHILGLWQPDIG---------------- ---------------PYGGLLNVV------------------------------------ -V-DG-LFIIGWMYLPPHDPHVDDQMRCKPLFRIHLME-KLATVK-----------CMYG -HKGPHNGHIQIVKKDEFSTKCIQTDFHRMPGGRQ---------EEFRTWL-GEEWGRTL --------------------EDIFHEHMQELILMKFIYTSQYD----------------- -NCLTYRRIYLP--LCAPDDLIKPGLFK-------------------------------- ---GTYGSHGL-EIIMLSFHGMRAKATKLTGDPNVPAGQLTFDVDLTRSVQLPDIENQHN FDELSRIVLEIHEQVQR------------------------------------------- ------------------------------------------------------------ --------------------------------------D--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------H--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PERR--------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------EE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------RAEQGAGE PQPGPSHHREPERRVENGQPAAGSATGSEA------------------------------ ------------------------------------------------------------ -----------------------------------------GQ----------------- -----------------------PFVLPIGVMARNESYPR----TCRMCFYG---IGQIA --------------------GHGFTSPEQT------------PGVFILFNDDCFGFIWLE LKSFSLYSRIKETLQNAEAPSR------------EAF-----------------EEMLKN MQS-WTT >ENSMLUP00000017667 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EES ACLCGVGSSRGC----------------------------------------R------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQRPA------------------E-- ------------K--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKP---- ---------------------------------------------------------AP- -AEKHVEA-DA-AVRCCA----------------D------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------TLSP------------------------------------- --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PS--------------LQAPR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPLEILVEIFASLPGTDLSSLAQTCTKFHHILHIDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGVCENLQNLETI-GMSYREVYAK-------------------------------LF--- ------------------------------PYRNILGLWQLDTE---------------- ---------------HYRTLVNVV------------------------------------ -L-DG-LCITGWTYRPSLHTHVGGPIHFKPSFRIRLTERRSATVE-----------CMEG PNSSPHYSHMQI-QKDRFTTQCKKTDHRTDLPTQL-----------------REEGGLVL --------------------ED----------------RQWYD----------------- --CLTYRRLYLP--PNHPDDLIRPGLFQ-------------------------------- ---DYYDDFGL-KIAMLSFHGKYARVTKITGLSKK-----TLEIHLMRRIQLRDGEIFRN FNELSRVVQEMDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- --------------------------------------------------Q--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------K------------- ------------------------------------------------------------ -----------------------------------------------QEEGTEESEGHGW -----------------------------------------QSP-------AQPRV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVRSRDQNYPR----TCRMCFYA---VDTVT --------------------LLGSAYPRRF------------PAIFILFDENHFGFIWLE VKYFFLYNRVQETFQNVEAPSP------------QAF-----------------LEMLKN IKA-STK >ENSMLUP00000022392 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EAS ACLCDVGSSRGC-WS------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQRPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKP---- ---------------------------------------------------------AP- -AENYVEG-DA-AARCCA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IGSP------------------------------------- --------------------------------ML-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PPPP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVKIFASLPGSDLPSLAQACTKFHHILHIDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGFRENLQNLEMI-GMSYREVYAK-------------------------------LF--- ------------------------------PYRNILGLWQLNTE---------------- ---------------HYRTLVNVV------------------------------------ -V-DG-LCITGWTYRPSLHTHVGGPIDFKPSFRIRLTERTSTMVE-----------CMEG LDSRPHNRHMQI-RKDRFTTQCKNTDHRTDSPTRL-----------------REEWGLVL --------------------ED----------------RPWYD----------------- --WLTYRRLYLP--PSHPDDLIRPGLFQ-------------------------------- ---YYYDVFGL-MIAMLSFHGKYARVTKITGISKK-----TLEIHLMRRIQLRDGELFRN FNELSRVVQEIDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- --------------------------------------------QQQQQQQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEENQGHGW -----------------------------------------QSP-------AQPSD---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVHSIDQNYPR----TCRMCFYG---VDTVT --------------------LLGFPYPRRF------------PGVFILFDENHFGFIQLE AKYFFLYGRVQNTFQNVESPSP------------QAF-----------------LEVLKN IQS-NLT >ENSMLUP00000017679 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCSVGSSRGC-RC------------------P------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQRPV------------------E-- ------------M--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKR---- ---------------------------------------------------------AP- -AKKHIEG-DV-AAWCCA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IASP------------------------------------- --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------P-----------------APH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVEIFAWVPGTHLPRLSQACTKFHHILHIDSIW-------------------RRR CH---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGVRENLQNLEMM-GMSYREVYAK-------------------------------LF--- ------------------------------PYRNILGLWQLDNE---------------- ---------------YYRTLVNVV------------------------------------ -V-DG-FCITGWKYRPSLHTHVGGPIHFKPSFRIRLTERKSATVE-----------CMEG LDSRPHNRHMQI-QKDRFTTRCKNTDHGTDLPTWL-----------------REEGGPVL --------------------ED----------------RQQYD----------------- --WLTYRRLYLP--PRHPDDLIRPGLFQ-------------------------------- ---YYYDAFGL-KIAMLSFHGKYARVTKITGVSKK-----TLEIHLMRRIQLRDGEIFHN FNELSRVVQEIDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- -----------------------------------------------QQQQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESQGHGW -----------------------------------------QSP-------AQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVRSRDQNYPQ----TCRMCFYG---VDTVT --------------------LPGLAYHRRF------------PGVFILFDENHFGFIWLE AKYFFLCGRVQNSFQNVEAPSP------------QAF-----------------LEMLKN IQS-WFT >ENSMLUP00000017533 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCGVGSSRGC-RC------------------P------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQRPA------------------E-- ------------K--AAA------------------------------------------ -A---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKP---- ---------------------------------------------------------AP- -AEKHVQG-DA-AA---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------G--------------------------------- -------------------AVEP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PPP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVEIFAWVPATDLPSLAQACTKFHHILHIDSNW-------------------RRC CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGIRENLQNLEMM-GMSYREVYAK-------------------------------LF--- ------------------------------PYRNILGLWQLDTE---------------- ---------------RYRILVNVV------------------------------------ -V-DG-LCITGWTYRASLHTHVGGSIHFKLSFRIRLTERKSATVE-----------CMEG LDSRPHNRHMQI-LKDRFTTRCKKKDHGTDSPTRL-----------------REEGGLVL --------------------ED----------------RQRYD----------------- --WLTYRRLYLP--PSHPDDLIRPGLFQ-------------------------------- ---DYYDGFGL-KIAMLSFHGKYARVTKITGDPIR-----TLEIHLMRRIQLRDGEIFRN FNELSRVVQEIAEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------EQQQQ----------------- -------------------------------------------QQQQQQQQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESEGHGW -----------------------------------------QSP-------AQPSV---- -----------------------------GESRAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVLSRDQNYPG----TCRMCFYG---VDTVT --------------------LPGLAYHECF------------PGVFILFDENHFGFIRLE AKYFFLWGRVQNTFQNVEAPSPAGFPGDAQEHSP-------------------------- ----WTS >ENSMLUP00000018749 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCGVGSSRGC-RC------------------P------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KHQHPA------------------E-- ------------M--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKP---- ---------------------------------------------------------AP- -AEKHVEE-DA-AAGCCA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IASP------------------------------------- --------------------------------MP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PPPP------------------QH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEVLVEIFAWVPATDLPSLAEACTKFHHTLHIDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGIRENLQNLEMI-GMSYREVYAK-------------------------------LF--- ------------------------------PYRNILGLWQLD-H---------------- ---------------SYRTLLNVV------------------------------------ -V-DG-LCITGWKYRPSFHTHVSGPIHFKPVFRIRLTERKSATVE-----------CMEG LHSRPHNRQVLI-QKDRFTTHCNQTYHRKD-----------------------------L TASLRDEWV------QVLMGED----------------RQRYD----------------- --FLTYRRLYLP--LSHPDDLIRPGLFQ-------------------------------- ---YYLDDFGL-KIAMLSFHGKYAQVTDITGYSKM-----TLEIHLMRCIQLRDGEIFSN FNELSRVVQETDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESEGHGW -----------------------------------------QSP-------AQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVRSRVQNYPQ----TCRMCFYG---VDTLA --------------------IIGSSYRKSF------------PGVFILFDENHFGFIWPK AKHFFLYSRVQNTFQNVEAPSP------------QAF-----------------LEMLKS IQS-KNN >ENSMLUP00000018046 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLWVIGSLQGC-RC------------------P------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQRPA------------------E-- ------------R--TGA------------------------------------------ -Y---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EKHIEA-DR-AVGCCA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------MANP------------------------------------- --------------------------------IP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PSPP------------------PH--------- ------------------------------------------------------------ -----------------------------G------------------------------ ----------------------------------------L------------------- ---------------------------------------------------------LQD LPVEMLVEIFALLPGTDLPNLALACTKFHRILQTDSIW-------------------RQH CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGLCENLQNLETI-SMSYREVYAK-------------------------------LF--- -----------------------------HPYRHILGLWQLDTE---------------- ---------------GYRTLLNVV------------------------------------ -V-DG-LCITGWKNGPWLNTDVDGSMQFKPVFRIRLTERTSATVE-----------SMEG RHSRPHNRHATI-QKDRFTTQCNKTDHIKDLPRRL-----------------MDELGRLL ------------------IHED----------------RQQYD----------------- --CLTYRRLYLP--PSHPDDLIRPGLFQ-------------------------------- ---ANCNVFGL-SIAMLSFHGKYARLTKVTGDSNP-----SLEIHLMRRIQLPNGEMFSN FNELSRVVQEIDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- -------------------------------------------------QQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESEGHGW -----------------------------------------QGP-------AQQSV---- -----------------------------RESRAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFFLPVGVLSVDQNYPR----TCRMCFYA---VDTVT F----------------TVTLHGFACTGRF------------PGVFILFDENHFGFIWQK VNYFILFSRVQNTFQNVEAPSP------------QAF-----------------LEMLKN IQS---- >ENSMLUP00000019502 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLWVIGSLQGC-WC------------------P------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KHQRPA------------------E-- ------------S--TGADVRRADSTSDREHVPLGKDPSGCSGLPIPPDTE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------VEIFALLPGTDLPNLALACTKFHHILQTDSIW-------------------RQR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGLCENLQNLETI-SMSYLEVYAK-------------------------------LF--- -----------------------------HPYRHCLGLWQLDTE---------------- ---------------DYRTLLNVV------------------------------------ -V-DG-LCITGWTYRPCLNTHIDGPMQFKPAFRIRLTESKSATVE-----------CLEG HHSRPHNRRMQI-QKDRFNTQCNKTDHLKDVPRWL-----------------KDEWGRVL ------------------VQED----------------RQQYD----------------- --CLTYRRLYLP--PSHPDDLIRPGLFQ-------------------------------- ---ANCNAYGL-SIAMLSFHGKYARVTKVTGDSNP-----SLEIHLMRRIQLPDGEMFNN FNELSHVVQEIDKQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESEGHGW -----------------------------------------QSP-------AQQTV---- -----------------------------RESRAAT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFFLPVGVLSRDQNYPR----TCRMCFYA---VDTVT F----------------TVTLRGFAYTGRF------------LGVFILFDENHFGFIWQD VNYFILFSRVQNTFQNVEAPSP------------QAF-----------------LEMLKN IQS---- >ENSMLUP00000019336 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCVVGSSRGC-QC------------------C------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EGQGPV------------------E-- ------------T--AAA------------------------------------------ -Y---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EKHIEVDES-ADECCV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------FSSP------------------------------------- --------------------------------ML-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PPPP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVELLVEIFSSLPVTDLPSLALACIKFHHILHIDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGVCENLQNLEKI-SMSYREVYAK-------------------------------LL--- -----------------------------HPYRHILGLWQLDTE---------------- ---------------GYRGLLNVV------------------------------------ -V-DG-LCITGWTFRPCLNAHVDCPMLFEPTFRIRLTERKSATVE-----------CMEG RHSRPHNCHMQI-QKDRLTTQCKKTDHRKDSPARL-----------------RDEWGRVL ------------------VQKV----------------RQRYD----------------- --CLTYRRLYLP--PSQPDDLIRPGLFQ-------------------------------- ---CNCSAYGL-SIAMLSFHGKYARLTKVTGDSNH-----SLEIHLMRRIQLPDGEIFRN FNELSRVVQEIDKQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------RQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESEGHGW -----------------------------------------QSP-------AQPSV---- -----------------------------RESLAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ELP---------------------------------------V----------------- -----------------------PFVLPVGVLSMDQTYPR----TCRMCFYG---VDTFT Y----------------TVTLNGLACTGRH------------PGVFILFDENHFGFIWPE MNYFILFSRVQNTFQNVEAPSS------------RAF-----------------LEMLKN IQS-GPP >ENSMLUP00000018098 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACPCVMGSSRGC-RC------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQRPA------------------E-- ------------M--AAA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EKHVEA-EA-AARCCA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IASP------------------------------------- --------------------------------MT-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SPMP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVEISASLPGTDLPSLALACTKFHHILHIDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLQNLEAI-GISYREVYAK-------------------------------IF--- ------------------------------PYRHILGLWQLDTE---------------- ---------------DYRTLLNVV------------------------------------ -V-DG-LCITGWTYRPSLNTHVDGPMPFKPAFRICLTERESATVE-----------CMEG RHSRPHSRHLQI-QKDRFTTQCKKTDHRKDSPTWH-----------------RDEFGRWL ------------------VRED----------------RQQYD----------------- --CLTYRRLYLP--PSHPDDLIRPGLFQ-------------------------------- ---ANCNAYGL-SIAMLSFHGKYARLTTVTGDSNP-----SLEIHLRRRIQLRDGEIFRD FNELSREVQEIDEQVIW------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- -----------------------------------------------QQQQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESEGHGW -----------------------------------------QSP-------AQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVRSMDQNYPR----TCRMCFYG---RDTVT F----------------NVTLHGFAYTGRV------------PGVFILFDENHFGFLWLE AKYLVLFGRVQNTFQNVEAPSP------------QAF-----------------LEMLKN IQS-RPP >ENSMLUP00000022421 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCVVGSSRGC-RCH-----------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQRPA------------------E-- ------------M--AAAD-------------------------------SKRCRQECQG Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IASP------------------------------------- --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------QL------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVEIFASLPGTDLPSLALTCTKFHHILQTDSIW-------------------RQR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGLCENLQNLETI-GMSYREVYVK-------------------------------LF--- -----------------------------HPYRHILGLWQLDTE---------------- ---------------GCRTLLNVV------------------------------------ -V-DG-LCITGWTCRPCLNTHVDGPMQFKPAFRIRLTERTSATVE-----------CMEG CHSRPHNRHIQI-QKGRFTTQCNKTDHLKDVPTRL-----------------RDEWGRVL ------------------VQED----------------RHQYD----------------- --CLTYRRLYLP--PSHPDDLIRPGLFQ-------------------------------- ---AHCNVYGL-SIAMLSFHGNYARVTKVTGDSNP-----SLEIHLMRRIQLSDGEFFRN FNELSRLVQEIDEQVIL------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------Q----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESEGRGW -----------------------------------------QSP-------AQPSV---- -----------------------------REYRAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVHSRDQNYPR----TCRMCFYG---VDTVT F----------------TVTLNGFAHTGRE------------PGVFILFDENHFGFLWVE LKYFILFGRVQNTFQNVEAPSP------------QAF-----------------LEMLKN IQS-RPP >ENSMLUP00000017792 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCVLTSSRGC-PC------------------S------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ECQGPA------------------E-- ------------T--AVA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EKHIEA-DK-AAGCCA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IASP------------------------------------- --------------------------------MP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------FPPP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVELLVEIFALLPSTDLPSLALACTKFYHILHTDSIW-------------------RRR YR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGLCENLQNLETI-GMSYREVYWK-------------------------------LF--- -----------------------------HPYRHILGLWQLDTE---------------- ---------------GYRTLLNVV------------------------------------ -V-DG-LCITGWTYRPCLNTHVDGPMQFKPAFRIRLTERKSATVE-----------CMEG RISRPHSRHVQI-QKDRFSIQCIKTDHQKDSPTRL-----------------REAWGLVL ------------------VQED----------------RQQYD----------------- --CLTYRRLYLP--PSHPDDLIRPGLFQ-------------------------------- ---CKCNAYDL-SIAMLSFHGNYARVTKVTGDSKP-----SLEIHLMRRIQLPDGEIFRN FNELSRVVQEIDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- -------------------------------------------------QQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDRTVESEGHGW -----------------------------------------QSP-------AQTSV---- -----------------------------RVSGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVLSRDQNYPR----TCRVCFYG---VDTHT Y----------------TVALHGFAYTRHF------------PGVFILFDENHFGFISLP VKQFILFGRVQNTFQNVEAPSP------------QAF-----------------LEMLSN IQS-GPP >ENSMLUP00000022411 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCGVGSSPGC-RC------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QCQGPA------------------E-- ------------M--AAA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EKHVEA-NA-AARCCA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IESP------------------------------------- --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PP------------------LH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLMEIFASLPGNALPSLAQACTKFHHILHTDRIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVRETLQNLEKI-GMSYREVYVK--------------------------------L--- -----------------------------FPYRHILGLWQLDTE---------------- ---------------DYRTLLNVV------------------------------------ -V-DG-LCITGWTYGPSLDTHVDGPLQFEPSFRIRLTERKSATVE-----------CMEG RLRRPHNRHMQI-QKDRLTIHCNKTDHRKDLTARL-----------------REDRELVL ------------------GRED----------------RYQYD----------------- --CLAYRRLYLP--PSHPDDLIRPGLFQ-------------------------------- ---GNYDAFGL-KIVMLSFHGKYARVTKITGDSIG-----MLEIHLMRRIQLLEGKIFRN FKQLCRVVHEIDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------QQQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESEGHGW -----------------------------------------QRP-------AQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVRSIDQNYPR----TCRMCFYG---VDTVT --------------------LSGSAYRKRF------------PGVFILFDENHFGFTWLE LKYFILYGRVQNTFQNVEAPSP------------QAF-----------------LEMLKD IHS-EPP >ENSMLUP00000021644 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EKC AGLCDVGSSRGC-RC------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QCQGPA------------------E-- ------------I--EAA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKL---- ---------------------------------------------------------AP- -AEKHVEA-DA-A----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------H--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVEIFAWVPGTDLPSLAQACTKFHHILHTDSIW-------------------RRR CR---------------------------------------------------------- ---------------K-------------------------------------------- -----------------------------------------------------------E YGVRENLQNLETI-GMSYREVYAK-------------------------------VL--- -----------------------------HPYRHILGLWQLDTE---------------- ---------------HYRTLLNVM------------------------------------ -V-DG-LCITGWTYGPSFNTHENGPLQFKPSFRIRLTERKSATVE-----------CMEG LHIRPHKRHVQI-QKDRFTLQCNKTDHQKDLTARF-----------------REELALVL R----------------LGQED----------------RYQYD----------------- --CLAYRRLYLP--SSHPDDLIRPGLFQ-------------------------------- ---GIYDSFSL-KIVMLSFHGNYARVTKITGVSKG-----LLEIHLMCRIQLPDGEFFRN FNELSLVIQEIDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------QQQ--------- -----------------------------------------------------Q------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DGIEESEGHGW -----------------------------------------QSP-------AQPNV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGTLTRDQNYPQ----TCRMCFYG---VDTVI --------------------SPVLAYPKRF------------PGVFILFDENHFGFIWLE LKYFILFGRVQNTFQNVEAPSP------------QAF-----------------LEML-- ------- >ENSMLUP00000019025 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC AGLCSVGSSWGC-RCGQQYQGPAETAAAEAKRCP------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRHRPA------------------E-- ------------T--AAA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IASP------------------------------------- --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------SP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVEIFASLPGTDLPSLALACTKFHHILYTDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGIRENLENLEMI-GMSYREVYAQ-------------------------------LF--- ------------------------------PYRHILGLWQLDTE---------------- ---------------GYRTLLNVV------------------------------------ -V-DG-LCITGWTYGLSLNTHVDGPLQFKPGFRIRLTERKPATVE-----------CLEG LHSRPHHRHMQI-QKDRLTLWCNNRDHRKVLTMRL-----------------RGERGRVL ------------------VRED----------------RYQYD----------------- --CLTYRRLYLP--PSHLGNLIRPGLFQ-------------------------------- ---GNYDVFGL-MIAMLSFHGKYARVTKITGNSNG-----TLEIHLMRRIPLPGGEIFRN FNELSHVVQEIDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- -------------------------------------------------QQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QENGTEESEGHGW -----------------------------------------QNR-------AQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPEGVRSRNQNYPG----TCRMCFYA---VDTVT SYG------------SVSI---------RF------------PGVFILFDENHFGFICLE VKYFILFSRVQNTFQNVEAPSP------------QAF-----------------LEMLKD IHS-RTP >ENSMLUP00000016906 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC TCLCGLGSSRGC-RC------------------H------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ECQGPA------------------E-- ------------T--ATA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------ISSP------------------------------------- --------------------------------RP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PTPP------------------LH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEVLVEIFGSLPGTDLPSLALACTKFHHILHTDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGLRENLQNLEMM-GMSYREVYAK-------------------------------LF--- -----------------------------HPYRGILGLWQLDTE---------------- ---------------HYRTLLNVV------------------------------------ -V-DG-LRITGWTYGPCLNLHVDGPMQFKPSFRIRLTERKSATVE-----------CMEG RHSRPHSRHIQI-RKNRFSTQCNKTDHLKDLPARL-----------------REDWGRVL ------------------VGKD----------------RLRYD----------------- --CLTYRRLYLP--PSHPEDLIRPGLFQ-------------------------------- ---GKYHRFGL-IIAMLSFHGKYARVTKITGDFTQ-----TLEIHLMRRIQLGDGKIFRN FNKLYRLVLEIDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QEDGTEESGGHGW -----------------------------------------QSP-------AQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVRSRHQNYPR----TCRMCCYG---VDIVT --------------------PCGSGRPWRF------------PGVFILFDENHLGFICLE TKYFILFGRVQNTFQNVEAPSP------------QAF-----------------LKMLKN IQS-RPR >ENSMLUP00000020731 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC TCLCGLGSSRGC-RC------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ERQGPA------------------E-- ------------T--ATA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EKPLEA-DA-AALCCA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IASP------------------------------------- --------------------------------RP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PPPP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVELLVEIFGLLPGTDLPSLALACTKFHHILHTDSIW-------------------RRR CW---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGLRENLQNLETM-GMSYREVYAK-------------------------------LF--- -----------------------------HPYRGILGLWQLDTE---------------- ---------------GYKTLLNVV------------------------------------ -V-DG-LLITGWTYGPCLNLHVDGPMQFKPSFRICLTERKSATVE-----------CMEG RHSRPHSRHIQI-GKNRFSTQCNKTDHLKDLPTRL-----------------REDWARVL ------------------VQKD----------------RLQYD----------------- --CLTYRRLYLP--PSHPDDLIRPGLFQ-------------------------------- ---GKYHRFGL-MIAMLSFHGKYARVTKITGNFTQ-----TLEIHLMRRIQLGDGKIFRN FNTLYRVVLEIDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QEDGTEESGGHGW -----------------------------------------QSP-------AQPSV---- -----------------------------GESGAVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------KFVLPVGVSSRHQNYPR----TCRMCCYG---VDTVT --------------------TCGSGCPWRF------------PGVFILFDENHFGFISLE TKYFILFGRVQNTFQNVEAPSP------------QAF-----------------LKMLKN IQS-RPV >ENSMLUP00000017492 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C ACLCGLGSSRAC-QC------------------H------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ECQGPA------------------EKA APQGKPAPAEKH------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----LEA-DA-AALCCA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------D LPVEVLVEIFGSLPGTDLPSLALACTKFHHILHTDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGLRENLQNLEMM-GMSYREVYAK-------------------------------LF--- -----------------------------HPYRGILGLWQLDTE---------------- ---------------GYKTLLNVV------------------------------------ -V-DG-LLITGWTYGPCLNLHVDGPMQFKPSFRICLTERKSATVE-----------CMEG RHSRPHSRHIQI-GKNRFSTRCNKTDHLKDLPTRL-----------------REDWARVL ------------------VQKD----------------RLQYD----------------- --CLTYRRLYLP--PSHPDDLIRPGLFQ-------------------------------- ---GKYHRFGL-MIAMLSFHGKYARVTKITGNFTQ-----TLEIHLMRRIQLGDGKIFRN FNTLYRVVLEIDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QEDGTEESGGYGW -----------------------------------------QSP-------SQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVSSRLQNYPR----TCRMCFYG---VDIVT --------------------TCGSGCPWRF------------PGVFILFDENHFGFISLE TKYFILFGRVQNTFQNVEAPSP------------QAF-----------------LKMLKN IQS-RPV >ENSMLUP00000016723 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------FTKCQRPAEMANAEGK-- -------------RC------------------P------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQSPA------------------E-- ------------T--ATA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IASP------------------------------------- --------------------------------RP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PPPP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEVLVEIFGSLPGTDLPSLALACTKFHHILQTDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGLRENLQNLETI-GMSYREVYAK-------------------------------FF--- -----------------------------HPYRGILGLWQLDTE---------------- ---------------GYKTLLNVV------------------------------------ -V-DG-LCVTGWTYGPCLNLHVDGPMQFKPSFRIRLTERKSATVE-----------CMEG RHSRPHSRHIQI-RKNRFSTRCNKTDHLKDLPAQQ-----------------REDWGRVL ------------------VQKD----------------RLRYD----------------- --CLTYRRLYLQ--PNHPEDLIRPGLFQ-------------------------------- ---GKYHRFGL-MIAMLSFHGKYARVTKITGDFTQ-----TLEIHLRRRIQLGDGKIFRN FNKLYRVVLEIHEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------QEDGTEESGAHGW -----------------------------------------QSP-------AQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVRSRNQNYPR----TCRMCCYG---VDTVT --------------------TCCSGYPWRF------------PGVFILFDENHLGFICLE TKYFILFGRVQNTFQNVEAPSP------------QAF-----------------LKMLKN IQS-RPH >ENSMLUP00000016632 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCGVGSSRRC-WC------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQRPA------------------E-- ------------T--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKP---- ---------------------------------------------------------APA LAEKQVEA-DV-A----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------H--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVEIFASLPGTDLPRLAQACTKFHHILHIDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGVPETLQNLAMI-GMSYREIYAK-------------------------------LF--- -----------------------------HPYRHILGLWQLDNS---------------- ---------------N-RTLLNVV------------------------------------ -A-DG-LCITGWTYRPSLNTHGDGPLQFKPSFRIRLTERKSATVE-----------CMEG LHRRPHNHHMQI-RKDRFSIQCNKTDHRTDSPTRL-----------------RGERGLVL ------------------VQED----------------RQVYD----------------- --WLTYRRLYLP--PRHPDDLIRPGLFQ-------------------------------- ---SKYQIFRLKKIAMLSFHGKYARVTKIMGKSIA-----MLEIHLKRRIQLRDGEIFRN FNELSRVVQEIDEQVFR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QENGTEESEGHGW -----------------------------------------QSP-------VQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPANMLSIEQNYPR----TCRMCFYG---VDTVT --------------------RHGFPSTRRC------------PGVFILFDENHFGFICLE MRYFILFGRVQDTFQNVEAPSP------------QAF-----------------LEMLKD IQS-GPP >ENSMLUP00000018179 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCGVGSSREC------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------QRPA------------------E-- ------------M--AAA------------------------------------------ -N---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKP---- ---------------------------------------------------------AP- -AEKHVEA-DA-AARCCV----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IASP------------------------------------- --------------------------------ML-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------APPP------------------PC--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVEIFASLPGTDLPSLAQACTKFHHILHTDSIW-------------------RWR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGVRENLQDLKMI-GMSYRELYAK-------------------------------MF--- ------------------------------PYRNILGLWQLD-H---------------- ---------------GYRTLLNVV------------------------------------ -V-DG-LCITGWTCRPSLNTHVDGPMQFEPSFRIRLTERTSATVE-----------CMEG LHSRPHNSHMQI-QKDRFSIQCIKTDHRKDSPTRP-----------------WEERGRVL ------------------VQED----------------GQQYD----------------- --CLIYCRLYLP--P-DPDDLIRPGLFQ-------------------------------- ---GKYDAYGL-TIAMLSFHGKYARVTKVTGIAKTL----ALEIHLMRRIQLRDGEIFRN FNELSRVVQEIDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESQGHGW -----------------------------------------QSP-------ALPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVHSRDQNYPR----TCRMCFYG---VHMVT --------------------FHGFSYPRRF------------PGVFILFDENHFGFIWLE VKYFILNSRVQNTFQNVEAPSP------------QAFTSLLQ------FLYKQKL----- ------- >ENSMLUP00000021269 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC AFLCGVGSSR-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------GC--------RCPQKRQ--------- ------------------------------------------------------------ -----------------------------------------------RP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------AER------------------- ----------------AAANAKRWSGG--------------------------------- -------------------IASP------------------------------------- --------------------------------ML-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------APPP------------------PR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVEIFASLPGTDLPSLALACTKFHHILHTDSIW-------------------RRR CW---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGFRENLQDLKMI-GMSYRELYAK-------------------------------MF--- ------------------------------PYRNILGLWQLD-H---------------- ---------------GYRTLLNVV------------------------------------ -V-DG-LCITGWTCRPSLNTHVDGLMQFEPLFRIRLTERKSATVE-----------CMEG RHSRPHNRHMQI-QKDRFSIQCIKTDHQKDSPTRP-----------------WDERGRVL ------------------VQED----------------GQQYD----------------- --CLTYRRLYLP--PRHPDDLIRPGLFQ-------------------------------- ---GKYNAYCL-TIAMLSFHGKYARVTKIMGITKTL----ALEIHIMRRIQLRDGEISRS FNELSLAVQEIDQQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------Q----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESQGHGW -----------------------------------------QSP-------ALPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVQSRDQNYPR----TCRMCFYG---VHMVT --------------------FHGFTYPRRF------------PGVFILFDENHFGFIWLE VKYFILYSRVQNTFQNVEAPSP------------QAF-----------------LEMLKN I------ >ENSMLUP00000010216 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ASIGGLGSSRGH-RC------------------P------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQRPA------------------E-- ------------T--AAA------------------------------------------ -H---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SKP---- ---------------------------------------------------------SP- -AEKHVEA-AA-SARCC------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED LPVEMLVKIFASLPGSDLPRLAQACTQFHHILHIDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGVRENLRNPEMR-GMSYREVYAK-------------------------------LF--- ------------------------------PYRHILGLWQLNY----------------- ---------------SYRTLLNVA------------------------------------ -V-DG-LCITGRPYRPSLHTHGDDPIDFKPSFRIRLTERKPAAVE-----------CMAG LLGRPHNGHMQI-QEDRLTIQCKRTDHRTDSPTRLGE-------------RGRG-RGRGR ------------------VQED----------------GQQYD----------------- --CLTYRRLYLP--PRHPDDLIRPGLFQ-------------------------------- ---GKYSAFGP-TTVMLSFHGEYARVTRLMGIGTK-----ALEIHLMHRIQLRGGEIFHN INELSHVVLEIDEEVTW------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------EEDGSEESEGHGW -----------------------------------------QSP-------AQPSD---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVRSVDQNYPR----TCRMCFYG---MD--- -------------------------------MDPFAYPRHCCPGVFILFDEDHFGFIWLE EKYFFWYSRVQDTFQNVEAPSP------------QAF-----------------LEMLKD IHS-SFI >ENSMLUP00000020825 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC AGLCGVGSSRGH-RC------------------H------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQRPAEMAAADGKRCRQGCQRPTE-- ------------T--AAA------------------------------------------ -H---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SKP---- ---------------------------------------------------------AP- -AEKHVE----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------D LPVEMLVEIFASLPGTDLASLALTCTKFHHILHIDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGFRENLQNLEMI-GMSYREFYAK-------------------------------LF--- ------------------------------PYRHILGLWQLNY----------------- ---------------SCRTLLNVV------------------------------------ -V-DG-SCITGGTYRPSLNTHVRGPIHFKLSFRIRLTERKPAAVE-----------CMAG LLGRPHSGHMQI-QKDRLTIQCKRTDHRTDSPTRL-----------------RGERGRGR ------------------VQED----------------RQQYD----------------- --CLTYGRLYLP--PRHPDDLIRPGLFH-------------------------------- ---GKYNAFGP-TTVMLSFHGKYARVTRLMGIGTK-----TLEIHLMRRIQLRDGEIFRN FNELSRVVQEIDEQVTR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------QQQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTE------- ------------------------------------------SP-------AQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVRSSDQNYPR----TCRMCFYG---VD--- -------------------------------IDPFAYPRHCCPGVFILFDEEHFGFIWLE EKYFFWYGRVQDTFQNVEAPSP------------QAF-----------------LEMLKD IQS-SFI >ENSMLUP00000016709 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ASIGGLGPSRGH-RC------------------H------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQRRA------------------E-- ------------K--AAA------------------------------------------ -H---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SKP---- ---------------------------------------------------------SP- -AEKQVEA-DA-EARCS------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------LQD LPLEMLVKIFAWLPGTDLPSLAQACTKFHHILHIDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGVRENLQNLEMM-GMSYREVYAK-------------------------------LF--- ------------------------------PYRHILGLWQLNY----------------- ---------------SYRTLLNVG------------------------------------ -V-DG-SCITGWAYRPPLNTHARGPVHFKPWFRIRLTERKSAAVE-----------CMAG HLGRPHSGHMQI-QKDRLTIQCKKTDHRTDSPTRL-----------------RGERGRGR ------------------VQED----------------GQQYD----------------- --CLTYRRLYLP--PRHPDDLIRPGLFH-------------------------------- ---GKFNAFGP-TTVMLSFHGKYARVTRLMGIGTK-----ALEIHLMRRIQLRDGEIFRN FNELSRVVQEIDEQVTR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- -------------------------------------------------QQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESQGHGW -----------------------------------------QSP-------AQPSA---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVRSSDQNYPR----TCRMCFYG---VD--- -------------------------------IDPFAYPRHCCSGVFILFDEDHFGFIWLE EKYFFWYGRVQDTFQNVEAPSP------------QAF-----------------LEMLKD IQS-SFR >ENSMLUP00000017539 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCGVDSSRGC-RC------------------H------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQSPA------------------E-- ------------T--SAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKQ---- ---------------------------------------------------------AP- -AGEQVEA-DA-AARCC------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AD FPVEMLVEIFAWLPGTDLPSLAQACTKFHHILHIDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGVHENLQNLEMM-GMSHREVYAK-------------------------------LF--- -----------------------------HPYRHILGLWQLDTE---------------- ---------------GSRTLLNVA------------------------------------ -V-DG-SCITGWAYRPSLNTHARGPVHFKPWFRIRLTERKSAAVE-----------CMAG RISRPHNHHMQI-QKDRLTIQCK-TDHRTDSPRWL-----------------RGERGRGG ------------------VQED----------------GQQYD----------------- --CRTYRRLYLP--PRHPDDLIRPGLFQYYQDPFDLKIAMLSFHGKC-----AQVTDITG DSSGR------------------------------------LEIHLMRRIQLRDGEIFRN FNELSCVVQEIDEQVTR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ----------------------------------------------QQQQQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESQGHGW -----------------------------------------QSP-------AQPSA---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVRSIDRNYPR----TCRMCFYG---VDTVT ------------------VSFRGFSYTWRHA------------GVFILFDEDHFGFIWLE AKYFFLFRRVQDTFQNVEAPSP------------QAF-----------------LEMLKD IQS-GPP >ENSMLUP00000018502 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ASLCRVGSSRGR-RR------------------H------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQRPA------------------E-- ------------K--AAA------------------------------------------ -K---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKPA--- --------------------------------------------------------LAP- -AEQQVKT-DS-AAGCCA----------------E------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IPSP------------------------------------- --------------------------------MP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PPLA------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVEIFALLPGTDLPSLAQACTKFHHILHIDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGFCENLQNLEKI-GMSYQEVYVK-------------------------------LF--- -----------------------------HPYRHILGLWQLDND---------------- ----------------YRTLVNVV------------------------------------ -V-DG-LGITGWMYRPSLNTHVDGPMQFNPSFRICLTERKSAAVE-----------CMEG RHSRPHNCDMQI-RKDRFTTQCKKTDHRTDSPTRI-----------------REAWEQVL ------------------VQKG----------------RRQYD----------------- --CLTYRRLYLP--PSYPDDLIRPGLFQ-------------------------------- ---YNYDPFGL-KIAMLSFHGKYARVTKITGDSN------KLEIHLMHRIQLRDGEIFRN FNELALVVQEIDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QGDGTEESEGHGW -----------------------------------------QSP-------AQPSM---- -----------------------------EESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVPLVGMRSRDQHYPR----TCRMCFYG---VDTVT ------------------VTLCDFTFTRRL------------PGVFILFDENHFGFIWLE LKYFILFGRVQNTFRNVEAPSP------------QAF-----------------LEMLKN IQS-IRT >ENSMLUP00000018873 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCGVGSSREC-RC------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------GRQGPA------------------E-- ------------T--AAA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKP---- ---------------------------------------------------------AP- -AEKPLEA-EA-AAWCCA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------D LPVELLVEIFASLPGTNLPSLAQACTKFHHILHTDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVREKLQNLEMI-GMSYREVYTK-------------------------------LL--- -----------------------------HPYRNILGLWQPDQD---------------- ----------------YGTLLYVA------------------------------------ -A-DG-LCITGWTYGPCLNTHEDGPLQFKPSFRIRLTERKSATVE-----------CLEG RISRPHNCHVQI-RKDRLTLQCRKTDHRTDSPTRL-----------------RGERGWVL P-------------------QD----------------GQQYD----------------- --WVTYRRLYLP--PGHPGDLIRPGLFQF----------------KCEMCRRK------- ------------KIAMLSFHGKYARVTEIRGGLIW-----TLEIHLRRRIQLRDGGFFHD FNELSRVVREIGEQVIW------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESEGHGW -----------------------------------------QSP-------AQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPEGVRSSDQNYPR----TCRMCFYG---RDSVT --LGVFTRRRRHRGPD--------------------------HGVFILFDESHFGFIWLE RKYFILFGRVQNTFQNVEAPSQ------------QGF-----------------LEML-- ------- >ENSMLUP00000019596 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------AEC ACICGMGSLQGC-RC------------------P------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRQGPA------------------E-- ------------M--A-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -PEKNLEA-DR-AARCCL----------------E------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IENP------------------------------------- --------------------------------ML-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PRPP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVEIFAQLPGTDLLSLAQVCTKFHHILHTDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGVHENSQNLEMM-GMSYPEVYVK-------------------------------LF--- -----------------------------HPYRHILGLWQLDTDC--------------- --------------RGYRGLLNVV------------------------------------ -V-DG-LCITGWIYRPCLNTHVHGPIHFQPSFRIRLKERKSAVVE-----------CMEG RLSRPHHRHMQI-WKDRFTMQCKKTDRQTYLPRWL-----------------RRDRGLGL ------------------LQKD----------------RHEYD----------------- --CLTYRRLYLP--PSHPDDLIRPGLFQ-------------------------------- ---GNCDFYGL-TTVMLSFHGKYARVTQIMGNSIE-----RLEIHLMRRIQLPDGEFFRN FKELSRIVRKIDKQVIQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------L------------- ------------------------------------------------------------ -----------------------------------------------QEEGTEESEGHGW -----------------------------------------QSP-------AQPSI---- -----------------------------RESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ DQP---------------------------------------V----------------- -----------------------RFVLPVGVESGDQNYPR----TCRMCFYG---MDTVT --------------------SDGFAYPRGF------------PGVFILFDENHFGFICLD MKFFMLYGRVQNTFQNVEAPSP------------QAF-----------------LEMLKN IQS---- >ENSMLUP00000022672 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCRVGSSRGC-RC------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ECQGPA------------------E-- ------------R--AAA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKP---- ---------------------------------------------------------AP- -AEKHMEA-EA-AWRCCA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------ISSP------------------------------------- --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------RP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPPELLVEIFASLPGTDLPSLAQACTKFHHILHTDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGVPDNLPDQERR-GMSYREVYAK-------------------------------LFHPY RHILGLWQKSLPDQERRGMSYREVYAKLFHPYRHILGLWQLD-H---------------- ---------------HYRILLKVV------------------------------------ -V-DG-LCITGSKCWPPLMTDMEGPLQFPPSFRIRLTERKSATVE-----------YMDS FYSLSHSRHMQI-QKDRFSIQWIKRDQQKDSPTRL-----------------RGERGRVL ------------------LEED----------------RLPYY----------------- --CETYHRVYLP--PSHPDDLIRPGLFQ-------------------------------- ---GAFYDVRL-MIAVLSFHGKYARVTSVMGGFMW-----TLEIHLMRRIQPPDGEIFRN FNELSHVVQEIEEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------QQQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESEGHGW -----------------------------------------QSP-------AQPSV---- -----------------------------VESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVRTRDQNYPQ----TCRMCFYG---VNIVT --------------------SDGLAYPSRC------------PGVFILFDENHFGFIWLE LKYFFLFGRVQNTFQNVEAPSP------------QAF-----------------LEMLSN IQS-GPP >ENSMLUP00000022448 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACFCGLCSSRGC-RC------------------L------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KCQGPA------------------E-- ------------K--AAA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKP---- ---------------------------------------------------------AP- -AEKHLE----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVEIFTFLPGTDLASLAQACTKFRHILHNDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVREILQNLDMI-GMTYREVYAK-------------------------------IF--- ------------------------------PYRNILGLWQLDN----------------- ---------------SYGTLLNVV------------------------------------ -L-DG-FCITGWTYRPSLNTHLHGPIQSSPSFRIRLMAGKSATVE-----------YMDA IYSSSHSRHMQI-QKDRVSIQWIRRDHRKDSPTRL-----------------RGERVLVL ------------------LEKD----------------RRPHDCRAFGRVVLLSEENKVY GYCLTYRRFYLP--PSHPDDLIRPGLFH-------------------------------- ---GKFDGFSP-TIAMLSFHGKYARVTKITGESIE-----ILEIHLRRRIQLRDGEIFRN FKELSHVVQEIDKQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------G--------------------- -----------------------------------------------QQQQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QENGTEESEGHGW -----------------------------------------QSP-------AQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ELS---------------------------------------V----------------- -----------------------SFVLPVGVRSKDQNYPR----TCRMCFYG---VYSVR --------------------FHRITYSRRF------------PGVFILFDDNHLGFISLE EKFFNLFGRVQKTFQNVEAPS------------------------PTAF-----LEVLSN IQS-RPF >ENSMLUP00000018491 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EKHLEV-DT-EAQCCA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------ITSP------------------------------------- --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVEIFASLLGTDLASLAQACTKFYHILHNDSIW-------------------RRR CS---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGFRENLQNLDMN-GMSYREVYVK-------------------------------IF--- ------------------------------PFRNILGLWQLDN----------------- ---------------SYGTLLNVV------------------------------------ -L-DG-FCITGWTFKSDRNTPVHGPMQFKPSFRIRLTERKSATVE-----------YMDD IYSFSHSRHMQI-QKDRVSIQWIRRDQRKDSPTWL-----------------RGERGLVL ------------------LEKD----------------RRPHD-------------SQWY DYCLTYSRVYLP--PSHPDDLIRPGLFH-------------------------------- ---GKSDNFGP-MIAMLSFHGKYARVTKITGETME-----TLKIHLMRRIQLRDGEIFCN FKELSRVVQEIDKQVI-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QE--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QENGTEESEGHGW -----------------------------------------QSP-------AQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPMGVTSMYQNYPR----TCRMCFYG---VHSVT --------------------DLSITYSRRF------------PGVFILFDENHFGFISLE MEYFILFGRVQNTFQNVEAPSS------------QAFLDALQHSVPT------------- ------- >ENSMLUP00000022214 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCGLGSSRGC-RC------------------C------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQDPA------------------E-- ------------T--AKA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EKHLEA-DG-AARCWA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IASP------------------------------------- --------------------------------R--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLD LPVEMLVEICSSLPGTELPNLAQVCTKFHRILHSNSVW-------------------RRR CQ---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGLRENLQELEMI-ATSYREVYAK-------------------------------LF--- -----------------------------HPYRHILGLWQEDTEDYKTLLSYREVYAKLF HPYRHILGLWQEDTEDYKTLLYVA------------------------------------ -V-DG-LGITGWTYGPRLNTHVDGPMQFKPAFRIRLTEGKSATVE-----------CMEG CHRRPHSRHLQI-RRNMFSTHCNQRDHRKDSPGRL-----------------REEWGRGL ----RGD--------------------------------HRYD----------------- --WLTYRRLYLP--PSHPDDLIRPGLFQ-------------------------------- ---SKNLPFGL-MIAVLSFHGKYARVTKITGFSFG-----TLEIHLMRRIQLREGEIFRD FFELCCVVQEIQEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESEGRGW -----------------------------------------QSP-------GQPSV---- -----------------------------GESRAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ DQP---------------------------------------V----------------- -----------------------PFVLPVGTRLRDRDYPR----TCRMCFYG---VVTVT --------------------LHGLPW--RH------------PGVFILFDENHFGFIWLE VKSFILYGRVQNTFQNMEAPSP------------QAF-----------------QELLKS VQSCWVG >ENSMLUP00000021577 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCGLVSSWRF-RC------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQGPA------------------E-- ------------M--AAA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKL---- ---------------------------------------------------------AP- -AEKQLEA-DGAAARCWA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IASP------------------------------------- --------------------------------R--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LLD LPVEMLVEICASLPGTDLASLAQVCTKFRHILHIDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGVCENLQNPEMI-GTSYREVYAK-------------------------------LF--- -----------------------------HPYRHILGLWQLDNR---------------- ----------------YRELLYVA------------------------------------ -V-DG-LGITGWTYGPRLNTHVDGPMQFKPAFRIRLTERKSATVE-----------CMEG CHRRPHSRHLQI-QRNMFSTHCNKRDPRKGSPARL-----------------REDWGRGL ----RGD--------------------------------HRYD----------------- --WLTYRRLYLP--PSHPDDLIRPGLFQ-------------------------------- ---SKNLRFGL-MIAMLSFHGKYARVTEITGKLIQ-----TLEIHLMRCIQLPDGGFFRD FNELSRVVQEIDEQVLR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- --------------------------------------------------Q--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESEGHDW -----------------------------------------Q------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGTRSRDHNYPR----TCRMCFYG---VNTVT --------------------SYGVAW--RH------------PGVFILFDENHFGFIWLE VKSFVLYGRVQNTFQNVEAPSP------------QAF-----------------LEMLKS IQS-WVS >ENSMLUP00000020253 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCGVGSSRGC-WC------------------S------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------KRQGPA------------------E-- ------------K--AVA------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKP---- ---------------------------------------------------------AP- -AEKHLEA--A-AAWCCA----------------E------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------IASP------------------------------------- --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVEIFALLPGTDLLNLAQVCTKFDHILHIDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVRENLQNLDMI-GMSYREVYAK-------------------------------IF--- ------------------------------PYRNLLGLWQLDS----------------- ---------------SYRELLNVV------------------------------------ -M-DG-LGITGWIEHSYLYNHVDDQMQLVPAFRIRLRKRKSATLEYKNGHFRSFHLC--- --------RMQI-QKDRFSIQCNERDHQKDTPMRC-----------------RGKQRLVL ------------------SQED----------------R--------LRCV--------- -YCLTYRRVYLP--PSHPDDLIRPGLFQ-------------------------------- ---GKCDAFGL-TISMLSFHGKYARVTNITGFSFG-----TPEIHLMRRIPLRDGEIFRD FNELSRVVQEIDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- -------------------------------------------------QH--------- -----------------------------------------------------HQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESQGHGW -----------------------------------------QSP-------AQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVHSRDQNYPR----TCRTCFYG---VDTVT --------------------SYGSVW--RD------------PGIFILFDDNHFGFIWLE TKHFFLFGRVQNTFQNVEAPSP------------QAF-----------------LDMLSN IQG-WVG >ENSMLUP00000022114 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C ACLCGVGSSLGC-RC------------------H------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ECQGPA--------------------- -------------------------------------------------T---------- -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GKP---- ---------------------------------------------------------AL- -AKKHLDA-DT-EAQCCA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGG--------------------------------- -------------------ISSP------------------------------------- --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PP------------------PY--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVKIFALLLGTNLPSLAQACTKFHHILHTYSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVREILQNLKMI-SMSYGEVYAK-------------------------------LL--- -----------------------------HPYRNIWGLWQLDKD---------------- ----------------YGTLLNVV------------------------------------ -V-DG-LCITGGTCRPSHNTHVDDPMQFKPSFRIRLTERKSATLE-----------YLDD FYSFSHSRHLQI-RKDRFSILWIQRDHRMGLPPHI-----------------RREWGLEL ------------------VRED----------------RQQYD----------------- --WVTYCRLYLP--PRHP-NLIRPGLFQF----------------KDESFRPK------- ------------KIAILSFHGKYARVTEIRGGLIW-----TFEIHLRRRIQLRDGQIFRN FNELSRVVREIDEQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------Q----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESQGHGW -----------------------------------------QSP-------AQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------A----------------- -----------------------PFVLPVGVSSRDQSYPQ----TCRMCFYG---VHNVI --------------------LSGFHNLMRL------------PGVVILFDENHLGFISLE EKYFILLGRVQNTFQNVEAPSP------------QAF-----------------LEMLSN IQS-RHP >ENSMLUP00000021770 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACICGLGSSPGH-RC------------------R------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QSQGPA------------------E-- ------------T--AAA--EQAGS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------AP- -PEKHLRS---------------------------------------RSRQ--------- ------------------------------------------------------------ -----------------------------------------------RG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------AVR------------------- ----------------ELK-------G--------------------------------- -------------------IGSP------------------------------------- --------------------------------C--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------CP------------------TH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQ- --------------------------------HIDSIW-------------------RRR CR---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E FGVGENLQNLETI-GLSYREVYAK-------------------------------LF--- -----------------------------HPYRHILGLWQLGHD---------------- ----------------YRRLLNVM------------------------------------ -V-DG-LCITGWTYRPSLNTHLDGPLQFEPAFRIHLMERKSAAVE-----------CLEG RHSRPHHRHMQI-EKDRFTTQCDKTDHLTDSPTRL-----------------RGGRGLVL ------------------SQED----------------TQGFD----------------- --FLVYHRLYLP--PSHPDDLIRPGLFQ-------------------------------- ---GKYDRFGL-SIVMLSVHGKYSRVTKITGYSNE-----ILEIHLKHRIQLRDGEIFRD FDELSRVVQEIDKQVIR------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QKNGTEESEGHGW -----------------------------------------QSP-------AQPSV---- -----------------------------GESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGVSSLDQNYPR----TCRMCLYASVDTDTVT --------------------HYGFPYCMHY------------PGVFILFDEDHFGFICLE LKYFILYGRVQNTFQNVEAPSP------------QAF-----------------SEML-- ------- >ENSMLUP00000020891 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCSVGSSRGC-RC------------------L------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------QRQGPD------------------E-- ------------M--AAA------------------------------------------ -D---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SKP---- ---------------------------------------------------------AP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------APAR---------PRPRQKTPR--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEILVEIFASLPGTDLSSLAQACTKFHHILHIDSIW-------------------RRR CW---------------------------------------------------------- ---------------E-------------------------------------------- -----------------------------------------------------------E YGVCENLQNLETI-GMSYREVYAK-------------------------------LL--- -----------------------------HPYRNILGLWQLSNE---------------- ---------------LYGRLLNVA------------------------------------ -V-DGLLCITGWTNEPYHNPHVGGPMQFKPAFRIRLTERKSTMVA-----------CLEG -HSRPHSCFMQI-LKDRISIKCHPTHH---------YVMFGCIRERIPWWR-REERGLAL --------AQEYRPEP-------------------------------------------- -YCLTYRRLYLP--PSHRDDLFRPGLFQ-------------------------------- ---GNCDTNGL-KIAMLSFHGKYARVTKITGDASAAAWQETLEIHLMHSIQLPDGEFFRN FNELSRLVQEIHEQVIQ------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- -------------------------------------------------QQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEDGTEESESHGW -----------------------------------------QSP-------AQPSV---- -----------------------------RESGAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EPP---------------------------------------V----------------- -----------------------PFVLPVGVRSRDQNYPR----TCRLCFYA---LDTVT --------------------FYGSAYPRRF------------PAVFILFDENHFGFIRLE SRWLILYSRVQETFQNAEAPSP------------QAF-----------------LEMIKN FQS-GVH >ENSMLUP00000016240 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCGLGSSRGC-LC------------------P------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ECQGPA------------------E-- ------------T--AAA-------------------------------A---------- -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GRA---- ------------------------------------------------------------ ------------AAQGCA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------NGG--------------------------------- -------------------ISSS------------------------------------- --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVDIFASLPGTDLASLAQACTKFRDILHTDSIWRHAVTRSLAFLENCRNEDDR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------SYREVYTK-------------------------------MF--- ------------------------------PYRNLLCLWQLDY----------------- ---------------GYRRLLNVM------------------------------------ -VNDG-LCITDWMYGPRLNTHVDGPMQFEPSFRIHLMQRKSATVE-----------YMDD LYSFFHSRHMQI-QKDRFSIRWIQRDPRQDSPTRL-----------------RVGPGLEM ------------------SQED----------------RQLYD----------------- --RLTYRRLYLP--PSHPGDLISPGLFQ-------------------------------- ---GKSDGFGP-MIAMLSFHGKYARVTKIRGDLIW-----TLEVHLMHRIHLPDGETFHN FNELSHIVQEIEEQVIC------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ----------------------------------------------QQQQQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEKRTEESEGHGW ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---LAEPCAAQR--RGVLGCTFG------------------GV----------------- -----------------------SFVLHVGVRSGDQNYPR----ICRMCFYG---VHVDT --------------------LHGSAYPRRC------------PGVFILFDENHFRFIWLE MKYFILLGRVQNTFQHVEAP-P------------QAF-----------------LEMLSN IQP-GPP >ENSMLUP00000020993 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------M--------------EEC ACLCGLGSSRGC-LC------------------P------------------Q------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ECQGPA------------------E-- ------------T--AAA-------------------------------A---------- -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GRA---- ------------------------------------------------------------ ------------AAQGCA----------------G------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------NGG--------------------------------- -------------------ISSS------------------------------------- --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PP------------------PH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVDIFASLPGTDLASLAQACTKFRDILHTDSIWRHAVTRSLAFLENCRNEDDR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------SYREVYTK-------------------------------MF--- ------------------------------PYRNLLCLWQLDY----------------- ---------------GYRRLLNVM------------------------------------ -VNDG-LCITDWMYGPRLNTHVDGPMQFEPLFQIHLMQRKSATVE-----------YMDD LYSFFHSRHMQI-QKDRFSIRWIQRDPRQDSPTRL-----------------RVGPGLEM ------------------SQED----------------RQLYD----------------- --RLTYRRLYLP--PSHPGDLISPGLFQ-------------------------------- ---GKCDGFGP-MIAMLSFHGKYARVTKITGDLIW-----TLEVHLMHRIHLPDGETFHN FNELSHVVQEIEEQVIC------------------------------------------- ------------------------------------------------------------ --------------------------------------E--------------------- ---------------------------------------------QQQQQQ--------- -----------------------------------------------------QQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QEKRTEESEGHGW -----------------------------------------QSP-------VQPSV---- -----------------------------GESWAAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------SFVLHVGVRSGDQNYPR----ICRMSFYG---VHVDT --------------------LHGSTYPRRC------------PGVFILFDENHFRFIWLE MKYFILLGRVQNTFQHVEAP-P------------QAF-----------------LEMLSN IQP-GPP >ENSMLUP00000019666 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ACLCGLGSSRRC-RC------------------PQKRQRPAEMAAAEGKQCLQ------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ECQGPA------------------K-- ------------K--AA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------P----------------KTPH--------- ------------------------------------------------------------ -----------------------------C------------------------------ ----------------------------------------S------------------- ---------------------------------------------------------LQD LPVEMLVEIFASLQGTDLASLAQACTKFRHILHTDSIW-------------------RLC CH---------------------------------------------------------- ---------------Q-------------------------------------------- -----------------------------------------------------------E FGVQENLQKPEMIDGMSYREVYAK-------------------------------MF--- ------------------------------PYKNLLGLWQLDY----------------- ---------------GYRRLLNVV------------------------------------ -VDDG-LCITGWMYGPRLNTHVAGPMQFEPLFRIHLTQRKSAMVE-----------YMDH FYSFSHSRHMQI-QKDRFSNRWIQRDPRQDSPTRL-----------------RGGRWLEM ------------------SQED----------------RRLYD----------------- --RLTYRHLYNPHSPSHQDDLLRPGLFL-------------------------------- ---GKSDGFGL-MIAMLRFHGKYAWVTKIMGDLIW-----TLEIHLMRRIHLPDGKTFHN FKELSHVVQEIEEQVI-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------R--------- -----------------------------------------------------EQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ----------------------------------------------Q------------- ------------------------------------------------------------ -----------------------------------------------QENRTEESEGHGS -----------------------------------------QSP-------AQPH----- -----------------------------RESWAAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EQP---------------------------------------V----------------- -----------------------PFVLPVGLRSRDQNYPSPLPPTCRMCYYG---VHIVT --------------------LHGSAYPRRC------------PGVFILFDENHFGFIWLE MKYFILLGRVQNTFQHVEAPYL------------QAF-----------------LEMLSN IQP-GPP