>ENSBIXP00000021988 ------------------------------------------------------MT-DA- KYVLCRWKKRLWPAKVLAGTEKSAKN--KRKKGYFLNVQILSLDKKIKVKSAEAKVLRKV HIEDIASSL---ASQDGTPAAPLEELTYRRSLRVALDVLNE------------------- RQG-----------------------SSSREGTTPRPPRVK------------------- ------------------------------------------------------------ -------------------PMEPAS--------------------WPPK----------- -----------------------------------------------PSLSPSFLEDTAG SPGPTRRERMSQR----------------------------------------------- ------------------------------------------------------------ -----------------LSGLPAGEED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- --------EYGVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------EGLKRSG------------------------------------------- ---------------------------------------GLDA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PAMCSASGGAQDREASR KQQ-ADWMTPLGKQGRNPAQGPHSGQRVAPSS----EGAGQE------------------ ---DGETGAGPAALCS-----PPGGRDLSPLDG------CPA-EHLGLDSGQRP------ ------------------------------------------RAHMSPHS---------- ------------------------------------------------------------ -------------------------------------------------PAQ-------- ------------------------------------------------------------ ---------------------------------LGP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AEEAADTR-PLE--E-ARP----L------- -----------------------------------------------SEEFMEPSAVN-S LL-------EED------------------------------------------------ EDDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWHKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPR-GRGISV LLRRLKHFDCKEKQALLDEAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDVQGTRFPQLSGGDP-E--EPVAGSPQGR-RPAY--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------SHLRAILRNRKPSRWLKTFLSSGQYMTCVETYLEDE EQLDLVVKYLQGV-Y-KQAGCQLLARGHGDGIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYIRGPA------------------------- -------------------LSSR----EKEIFDNQLLEERN---RRC------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSBTAP00000009840 ------------------------------------------------------MT-DA- KYVLCRWKKRLWPAKVLAGTEKSAKN--KRKKGYFLNVQILSLDKKIKVKSAEAKVLRKV HIEDIASSL---ASQDGTPAAPLEELTYRRSLRVALDVLNE------------------- RQG-----------------------SSSREGTTPRPPRVK------------------- ------------------------------------------------------------ -------------------PMEPAS--------------------WPPK----------- -----------------------------------------------PSLSPSFLEDTAG SPGPTRRERMSQR----------------------------------------------- ------------------------------------------------------------ -----------------LSGLPAGEED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- --------EYGVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------EGLKRSG------------------------------------------- ---------------------------------------GLDA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PAMCSASGGAQDREASR KQQ-ADWMTPLGKQGRNPAQGPHSGQRVAPSS----EGAGQE------------------ ---DGETGAGPAALCS-----PPGGRDLSPLDG------CPA-EHLGLDSGQRP------ ------------------------------------------RAHMSPHS---------- ------------------------------------------------------------ -------------------------------------------------PAQ-------- ------------------------------------------------------------ ---------------------------------LGP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AEEAADTR-PLE--E-ARP----L------- -----------------------------------------------SEEFMEPSAVN-S LL-------EED------------------------------------------------ EDDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWHKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPR-GRGISV LLRRLKHFDCKEKQALLDEAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDVQGTRFPQLSGGDP-E--EPVAGSPQGR-RPAY--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------SHLRAILRNRKPSRWLKTFLSSGQYMTCVETYLEDE EQLDLVVKYLQGV-Y-KQAGCQLLARGHGDGIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYIRGPA------------------------- -------------------LSSR----EKEIFDNQLLEERN---RRC------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSBIXP00005002592 ------------------------------------------------------MT-DA- KYVLCRWKKRLWPAKVLAGTEKSAKN--KRKKGYFLNVQILSLDKKIKVKSAEAKVLRKV HIEDIASSL---ASQDGTPAAPLEELTYRRSLRVALDVLNE------------------- RQG-----------------------SSSREGTTPRPPRVK------------------- ------------------------------------------------------------ -------------------PMEPAS--------------------WPPK----------- -----------------------------------------------PSLSPSFLEDTVG SPGPTRRERMSQR----------------------------------------------- ------------------------------------------------------------ -----------------LSGLPAGEED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- --------EYGVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------EGLKRSG------------------------------------------- ---------------------------------------GLDA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PAMCSASGGAQDREASR KQQ-ADWMTPLGKQGRNPAQGPHSGQRVAPSS----EGAGQE------------------ ---DGETGAGPAALCS-----PPGGRDLSPLDG------CPA-EHLGLDSGQRP------ ------------------------------------------RAHMSPHS---------- ------------------------------------------------------------ -------------------------------------------------PAQ-------- ------------------------------------------------------------ ---------------------------------LGP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AEEAADTR-PLE--E-ARP----L------- -----------------------------------------------SEEFMEPSAVN-S LL-------EED------------------------------------------------ EDDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWHKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPR-GRGISV LLRRLKHFDCKEKQALLDEAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDVQGTRFPQLSGGDP-E--EPVAGSPQGR-RPAY--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------SHLRAILRNRKPSRWLKTFLSSGQYMTCVETYLEDE EQLDLVVKYLQGV-Y-KQAGCQLLARGHGDGIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYIRGPA------------------------- -------------------LSSR----EKEIFDNQLLEERN---RRC------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSBMUP00000004989 ------------------------------------------------------MT-DA- KYVLCRWKKRLWPAKVLAGTEKSAKN--KRKKGYFLNVQILSLDKKIKVKSAEAKVLRKA HIEDIASSL---ASQDGTPAAPLEELTYRRSLRVALDVLNE------------------- RQG-----------------------SSFREGTTPRPPRVK------------------- ------------------------------------------------------------ -------------------PMEPAS--------------------WPPK----------- -----------------------------------------------PSLSPSFLEDTAG SPGPTRRERMSQR----------------------------------------------- ------------------------------------------------------------ -----------------LSGLPAGEED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- --------EYGVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------EGLKRSG------------------------------------------- ---------------------------------------GLDA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PAMCSASGGAQDREASR KQQ-VDWMTPLGKQGRNPAQGPHSGQRVAPSS----EGAGQE------------------ ---DGETGAGPAALCS-----PPGGRDLSPLDG------CPA-EHLGLDSGQRP------ ------------------------------------------RAHMSPHN---------- ------------------------------------------------------------ -------------------------------------------------PAQ-------- ------------------------------------------------------------ ---------------------------------LGP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AEEAADTR-PLE--E-ARP----L------- -----------------------------------------------SEEFMEPSAVN-S LL-------EED------------------------------------------------ EDDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWHKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPR-GRGISV LLRRLKHFDCKEKQALLDEAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDVQGTRFPQLSGGDP-E--EPVAGSPQGR-RPAY--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------SHLRAILRNRKPSRWLKTFLSSGQYMTCVETYLEDE EQLDLVVKYLQGV-Y-KQAGCQLLARGHGDGIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYIRGPA------------------------- -------------------LSSR----EKEIFDNQLLEERN---RRC------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSCHIP00000024640 ------------------------------------------------------MT-DA- KYVLCRWKKRLWPAKVLAGTEKSAKN--KRKKGFFLNVQILSLDKKIKVKSAEAKVLRKV HIEDIASSL---ALQDGTPTAPLEELTYRRSLRVALDVLNE------------------- RQG-----------------------SSSREGTTPQPPRVK------------------- ------------------------------------------------------------ -------------------PTEPAS--------------------WPPK----------- -----------------------------------------------PGLSPSFLEDTAG SPGPTRRERVSQR----------------------------------------------- ------------------------------------------------------------ -----------------LSGLPAGEED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- --------ECRVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------EGLKRSG------------------------------------------- ---------------------------------------GLDA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PAVCSASGAVQDREASR KQR-ADWMTPLSKQGRNPAQGPRSGQRVGPSS----EGAGQE------------------ ---DGETGAGLAALCS-----PLGGRDLSPLDS------CPA-ERLGLDGGQRP------ ------------------------------------------RAHMGPHS---------- ------------------------------------------------------------ -------------------------------------------------PAQ-------- ------------------------------------------------------------ ---------------------------------LGP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AEEAADIR-PLK--E-ARP----S------- -----------------------------------------------SEEFMEPSAVN-S LL-------EED------------------------------------------------ EDDEE------------------------------------------------------- ---------------------------------------------PPRILLYRE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PPSFEVGMLVWHKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPR-GRGISV LLRRLKHFDCKEKQALLDEAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDVQGTRFPQLSGGDP-E--EPVAGNPQGR-RPAY--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------SHLWAILRNKKPSRWLKTFLSSGQYMTCVETYLEDE EQLDLVVKYLQGV-Y-EQAGCQLLARGHGDGIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYETAEKKYIRGPV------------------------- -------------------LSSR------------------------------------- -----------------------------------ADVHLPLVLPR-------------- ---------HLAATAV-------------------------------------------- ----------------------------------------------- >ENSOARP00000012384 ------------------------------------------------------MT-DA- KYVLCRWKKRLWPAKVLAGTEKSAKN--KRKKGFFLNVQILSLDKKIKVKSAEAKVLRKV HIEDIASSL---ASQDGTPTAPLEELTYRRSLRVALDVLNE------------------- RQG-----------------------SSSREGTTPRPPRVK------------------- ------------------------------------------------------------ -------------------PTEPAS--------------------WPPK----------- -----------------------------------------------PGLSPSFLEDTAG SPGPTRRERVSQR----------------------------------------------- ------------------------------------------------------------ -----------------LSGLPAGEED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- --------ECRVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------EGLKRSG------------------------------------------- ---------------------------------------GPDA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PAVCSASGAVQDREASR KQR-ADWMTPLSKQGRNPAQGPCSGQRVGPSS----EGAGQE------------------ ---DGETGAGLAALCS-----PLGGRDLSPLDS------CPA-ERLDLDGGQRL------ ------------------------------------------RAHMGPHS---------- ------------------------------------------------------------ -------------------------------------------------PAQ-------- ------------------------------------------------------------ ---------------------------------LGP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------AEEAADIR-PLK--E-ARP----S------- -----------------------------------------------SEEFMEPSAVN-S LL-------EED------------------------------------------------ EDDEE------------------------------------------------------- ---------------------------------------------PPRILLYRE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PPSFEVGMLVWHKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPR-GRGISV LLRRLKHFDCKEKQALLDEAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDVQGTRFPQLSGGDP-E--EPVAGNPQGR-RPAYRKVLHPACRKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------SHLWAILRNKKPSRWLKTFLSSGQYMTCVETYLEDE EQLDRVVKYLQGV-Y-EQAGCQLLARGHGDGIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYETAEKKYIRGPV------------------------- -------------------LSSR----EKEIFDNQLLEERN---RRC------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSTTRP00000010436 ------------------------------------------------------ITMDA- KYVLCRWKKRLWPAKVLAGTEKSAKN--KRKKEFFLHVQILSLDKKIKVKSTGAQILKKS HIEGIASSL---ALQNEVAATPLEELAYRRSLRVALDVLNERT---------------RP RQG-----------------------RSSREERTTQSLRVK------------------- ------------------------------------------------------------ -------------------PTEPASSLCHSS--------PSPLLH--------------- -------------------------------------------------------EDASG SPGHTRRERAPQR----------------------------------------------- ------------------------------------------------------------ -----------------LSGLPARKED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------GCRVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLGRSG------------------------------------------- ---------------------------------------GLRA----------------- ------------------------------------------------------------ ---------------RAVSLA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GSGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGRGSRKH RANRTV------------------------------NR---------------------- -------------------TTTPSKRE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNLARGPS------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------WGQE------------------- --------------------------------------------A--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------P-PS--SEGAREEEDGGGLAALRSSPGGGAEGPRGG- ---------------------------PPVATPA-------------------------- ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------------------------------ -------------------VDSPEAGAPHGSAQLSSAPQRR------------PETPG-- GRKPRRGGG--------------------CAGEGAASASPVAHP---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------RP----P------- -----------------------------------------------SEESVELDAVN-S LL-------AED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRILLYRE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VRSVRRRDKKASVLFIEGNMNPK-GRGITV SLRRLKHFDCKEKQALLDEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQRDVQGTRFPPLSGVGP-E--QALAGNPRGR-RPAC--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------SHLRAILKNRKPSRWLKTFLSSGQYVTCVETYLEDE EQLDLVVKYLQGV-Y-QEAGSRLLARRHADGIRFVLDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYIRGPS------------------------- -------------------LSYR----EKEIFDTQLLEERS---R--------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSMLEP00000020020 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEYFLDVQILSLEEKIKVKSTEVEILEKS QIEAIASSL---ASQSEVPAAPLEELAYRRSLRVALDVLSEGPIWSQ-ESSAGTGRADQS LREKPTEHVSSPCDSNFSSLPRGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GPHRRSQC------------------------------------ ------------------------------------------------------------ -------------VQQSLSGSFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------ECKAD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSE------------------------------------------- ---------------------------------------NPRG----------------- ------------------------------------------------------------ ---------------LSVLSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DESGSRIH RKNW-------------------------------------------------------- --------------------TLASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSVQKSSLCRNGSSLS-EG----D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AERDMGSKGGSW- ------------------------------------------------------------ ---AAPSSPSGVREDDPCANAEGRDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTVP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------EPSACS--------EPRE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RPAKKRLRLDGSQRPPAAQLE PR---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGDAPV----------PGP-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RESMTLRSTTRLGPPPSHA S----------------------------------------------------------- ----------------------VDETRRPP------------------------------ --------------------------------------------CPDSQ----------- --------------------------------------KLE--E-DCQ----S------- -----------------------------------------------SEASMGPNSVR-S VL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYKKYPFWPAV------ ------------------------------VKSVRQREKKASVLYIEGHMNPK-KKGFTV SLKSLKHFDCKEKQTLLNQARVDYDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVPGTRFPQLSKGSP-E--EPVVGRPLGQ-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDLVVKYLQGV-Y-QEVGAKVLRRTNGDRIRFILDVLLP-------E----------- ------VSRRLVSRALDPCAETE----------PCQHQGVRTPSPP-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------W----------- ------------------------------------------------------------ ------------------------------------AHRCSPASVGYHLCDLCSGRGGLQ D-G-------------------------------------------- >ENSCATP00000015381 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEYFLDVQILSLEEKIKVKSTEVEILEKS QIEAIAASL---ASQSEVPAAPLEELAYRRSLRVALDVLSEGPIWSQ-ESSAGTGRADQS LREKPTEHVSSPCDSNFSSLPRGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GPHRRRQC------------------------------------ ------------------------------------------------------------ -------------VQQSLSGSFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------ECKAD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSE------------------------------------------- ---------------------------------------NPRG----------------- ------------------------------------------------------------ ---------------LSVLSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DESVSRIH RKNW-------------------------------------------------------- --------------------TLASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSVQKSSLCRNGSSLS-EG----D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AERDMGSKGGSW- ------------------------------------------------------------ ---AAPSSPSGVREDDPCANAEGRDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTVP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------EPSACS--------EPRE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RPAKKRLRLDGSQRPPAAQLE PR---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGDAPA----------PRP-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RESMTLRSTTRLGPPPSHT S----------------------------------------------------------- ----------------------VDETRRPP------------------------------ --------------------------------------------CPDSQ----------- --------------------------------------KLE--E-DCQ----S------- -----------------------------------------------SEASMGPNSVR-S VL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYKKYPFWPAV------ ------------------------------VKSVRQRDKKASVLYIEGRMNPK-RKGFTV SLKSLKHFDCKEKQTLLNQARVDYDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVPGTRFPQLSKGSP-E--EPVVGRPLGQ-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDLVVKYLQGV-Y-QEVGAKVLRRTNGDRIRFILDVLLP-------E----------- ------VSRRLVSHALDPCAETE----------PCQHQGVRTPSPP-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------W----------- ------------------------------------------------------------ ------------------------------------AHRCSPASVGYHLCDLCSGRGGLQ D-G-------------------------------------------- >ENSPANP00000045539 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLSRTETSTKN--KRKKEYFLDVQILSLEEKIKVKSTEVEILEKS QIEAIASSL---ASQSEVPAAPLEELAYRRSLRVALDVLSEGPIWSQ-ESSAGTGRADQS LREKPTEHVSSPCDSNFSSLPRGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GPHRRRQC------------------------------------ ------------------------------------------------------------ -------------VQQSLSGSFTCEED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------EYKAD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSE------------------------------------------- ---------------------------------------NPRG----------------- ------------------------------------------------------------ ---------------LSVLSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DESGSRIH RKNW-------------------------------------------------------- --------------------TLASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSVQKSSLCQNGSSLS-EG----D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AERDMGSKGGSW- ------------------------------------------------------------ ---AAPSSPSGVREDDPCANAEGRDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTVP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------EPSACS--------EPRE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RPAKKRLRLDGSQRPPAAQLE PR---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGDAPA----------PGP-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RESMTLRSTTRLGPPPSHA S----------------------------------------------------------- ----------------------VDETRRPP------------------------------ --------------------------------------------CPDSQ----------- --------------------------------------KLE--E-DCQ----S------- -----------------------------------------------SEASMGPNSVR-S VL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYKKYPFWPAV------ ------------------------------VKSVRQRDKKASVVYIEGHMNPK-RRGFTV SLKSLKHFDCKEKQTLLNQARVDYDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS CPVRKSIQQDLLGTRFPQLSKGSP-E--EPVVGRPLGQ-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDLVVKYLQGV-Y-QEVGAKVLRRTNGDRIRFILDVLLP-------E----------- ------VSRRLVSRALDPCAETE----------PCQHQGVRTPSPP-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------W----------- ------------------------------------------------------------ ------------------------------------AHRCSPASVGYHLCDLCSGRGGLQ D---------------------------------------------- >ENSMFAP00000041768 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEYFLDVQILSLEEKIKVKSTEVEILEKS QIEAIASSL---ASQSEVPAAPLEELAYRRSLRVALDVLSEGPIWSQ-ESSPGTGRADQS LREKPTEHVSSPCDSNFSSIPRGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GPHRRRQC------------------------------------ ------------------------------------------------------------ -------------VQQSLSSSFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------ECKAD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSE------------------------------------------- ---------------------------------------NPRG----------------- ------------------------------------------------------------ ---------------LSVLSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DESGSRIH RKNW-------------------------------------------------------- --------------------TFASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSVQKSSLCRNGSSLS-EG----D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AERDMGSKGGSW- ------------------------------------------------------------ ---AAPSSPSGVREDDPCANAEGRDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTVL-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------EPSACS--------EPRE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RPAKKRLRLDGSQRPPAAQLE PR---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGDAPA----------PGP-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RESMTLRSTTRLGPPPSHA S----------------------------------------------------------- ----------------------VDETRRPP------------------------------ --------------------------------------------CPDSQ----------- --------------------------------------KLE--E-DYQ----S------- -----------------------------------------------SEASMGPNSVR-S VL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYKKYPFWPAV------ ------------------------------VKSVRQRDKKASVVYIEGQMNPK-RKGFTV SLKSLKHFDCKEKQTLLNQARVDFDQAIGWCISLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDAPGTRFPQLSKGSP-E--EPVVGRPLGQ-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDLVVKYLQGV-Y-QEVGAKVLRRTNGDRIRFILDVLLP-------E----------- ------VSRRLVSRALDPCAETE----------PCQHQGVRTPSPP-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------W----------- ------------------------------------------------------------ ------------------------------------ANRCSPASVGYHLCDLCSGRGGLQ D-G-------------------------------------------- >ENSMNEP00000003974 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEYFLDVQILSLEEKIKVKSTEVEILEKS QIEAIAASL---ASQSEVPAAPLEELAYRRSLRVALDVLSEGPIWSQ-ESSAGTGRADQS LREKPTEHVSSPCDSNFSSLPCGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GPHRRRQC------------------------------------ ------------------------------------------------------------ -------------VQQSLSGSFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- --------ECKAD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSE------------------------------------------- ---------------------------------------NPRG----------------- ------------------------------------------------------------ ---------------LSVLSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DESVSRIH RKNW-------------------------------------------------------- --------------------TLASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSVQKSSLCRNGSSVS-EG----D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AERDMGSKGGSW- ------------------------------------------------------------ ---AAPSSPSGVREDDPCANAEGRDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTVP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------EPSACS--------EPRE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RPAKKRLRLDGSQRPPAAQLE PR---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGDAPA----------PGP-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RESMTLRSTTRLGPPPSHA S----------------------------------------------------------- ----------------------VDETRRPP------------------------------ --------------------------------------------CPDSQ----------- --------------------------------------KLE--E-DCQ----S------- -----------------------------------------------SEASTGPNSMR-S VL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYKKYPFWPAV------ ------------------------------VKSVRQRDKKASVVYIEGHMNPK-RKGFTV SLKSLKHFDCKEKQTLLNQARVDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDAPGTRFPQLSKGSP-E--EPVVGRPLGQ-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDLVVKYLQGV-Y-QEVGAKVLRRTNGDRIRFILDVLLPRVFTSHQ------------ ------------SRALDPCAETE----------TCQHQGVRTPSPP-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------W----------- ------------------------------------------------------------ ------------------------------------AHRCSPASV--------------- ----------------------------------------------- >ENSCANP00000020965 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEYFLDVQILSLEEKIKVKSTEVEILEKS QIEAIASSL---ASQNEVPVAPLEELAYRRSLRVALDVLSEGPIWSQ-ESSAGTGRANQS LREKPTEHVSSPCDSNFSSLPRGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GPHRGRQC------------------------------------ ------------------------------------------------------------ -------------VQQSLSSLFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------ECKAD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSE------------------------------------------- ---------------------------------------NPRG----------------- ------------------------------------------------------------ ---------------LSVLSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GESGSRIH RKNW-------------------------------------------------------- --------------------TLASKKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSVQKSSLCRNGSSLS-EG----D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AERDMGSKGGSW- ------------------------------------------------------------ ---AAPSSPSGVREDDPCANAEGRDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTVP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------EPSACS--------EPRE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CPAKKRLCLDGSQRPPAAQLE PG---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGETPS----------PGP-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RESMTLRSTARLGPPPSHA S----------------------------------------------------------- ----------------------VDESRRPP------------------------------ --------------------------------------------CLDSQ----------- --------------------------------------KLE--E-DCQ----S------- -----------------------------------------------SKASMGSNSMR-S VL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PHSFEVGMLVWLKYKKYPFWPAV------ ------------------------------VKSVRQRDKKASVLYIEGHMNPK-RKGFTV SLKSLKHFDCKEKQTLLNQAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPPLSKGSP-E--EPVVGRPLGQ-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDLVVKYLQGI-Y-QEVGAKVLRRTNGDRIRFILDVLLP-------E----------- ------VSRRPVSRALDPCAETEPRGHCPKLSAP----GVRTPSPP-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------W----------- ------------------------------------------------------------ ------------------------------------AHRCSPASVGYHLRDRCSGRGGLQ D-G-------------------------------------------- >ENSRBIP00000025387 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLARTETSTKI--KRKKEYFLDVQILSLEEKIKVKSTEVEILEKS QIEAIASSL---ASQNEVPAAPLEELAYRRSLRVALDVLSEGPIWSQ-ESSTGTGTADQS LREKPTEHVSSPCDSNFSSLPRGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GPHTGRQC------------------------------------ ------------------------------------------------------------ -------------VQQSLSSSFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------ECKAD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSE------------------------------------------- ---------------------------------------NPRD----------------- ------------------------------------------------------------ ---------------LSVLSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GESGSRIH RKNW-------------------------------------------------------- --------------------TLASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSVQKSSLCRNGSSLS-EG----A-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AERDMGSKGGSW- ------------------------------------------------------------ ---AAPSSPSGVREDDPCANAEGRDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTVP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------EPSACS--------EPRE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RPAKKRLRLDGSQRPRAAQLE PR---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGDAPS----------PGL-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RESMTLRSTTRLGPPPSHA S----------------------------------------------------------- ----------------------VDESRRPP------------------------------ --------------------------------------------CPDSQ----------- --------------------------------------KPE--E-DCQ----S------- -----------------------------------------------SEASMGSNSMR-S VL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYKKYPSWPAV------ ------------------------------VKSVRQRDKKASVLYIEGHMNPK-RKGFTV SLKSLKHFDCKEKQTLLNQAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGSP-E--EPVVGHPLGQ-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDLVVKYLQGV-Y-QEVGAKVLRRTNGDRIRFILDVLLPRVFTSHQ------------ ------------SRALDPCAEMEPRGSCPKLSAP----GVRTPSPP-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------W----------- ------------------------------------------------------------ ------------------------------------VHRCSPASVGYHLCDLCSGRGGLQ D---------------------------------------------- >ENSRROP00000018387 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLARTETSTKI--KRKKEYFLDVQILSLEEKIKVKSTEVEILEKS QIEAIASSL---ASQNEVPAAPLEELAYRRSLRVALDVLSEGPIWSQ-ESSTGTGTADQS LREKPTEHVSSPCDSNFSSLPRGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GPHTGRQC------------------------------------ ------------------------------------------------------------ -------------VQQSLSSSFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------ECKAD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSE------------------------------------------- ---------------------------------------NPRD----------------- ------------------------------------------------------------ ---------------LSVLSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GESGSRIH RKNW-------------------------------------------------------- --------------------TLASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSVQKSSLCRNGSSLS-EG----A-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AERDMGSKGGSW- ------------------------------------------------------------ ---AAPSSPSGVREDDPCANAEGRDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTVP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------ESSACS--------EPRE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RPAKKRLRLDGSQRPRAAQLE PR---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGDAPS----------PGP-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RESMTLRSTTRLGPPPSHA S----------------------------------------------------------- ----------------------VDESRRPP------------------------------ --------------------------------------------CPDSQ----------- --------------------------------------KPE--E-DCQ----S------- -----------------------------------------------SEASMGSNSMR-S VL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYKKYPSWPAV------ ------------------------------VKSVRQRDKKASVLYIEGHMNPK-RKGFTV SLKSLKHFDCKEKQTLLNQAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGSP-E--EPVVGHPLGQ-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDLVVKYLQGV-Y-QEVGAKVLRRTNGDRIRFILDVLLPRVFTSHQ------------ ------------SRALDPCAEMEPRGSCPKLSAP----GVRTPSPP-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------W----------- ------------------------------------------------------------ ------------------------------------VHRCSPASVGYHLCDLCSGRGRLQ D---------------------------------------------- >ENSTGEP00000013346 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLSRTETSTKN--KRKKEYFLDVQILSLEEKIKVKSTEVEILEKS QIEAIASSL---ASQSEVPAAPLEELAYRRSLRVALDVLSEGPIWSQ-ESSAGTGRADQS LREKPTEHVSSPCDSNFSSLPRGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GPHRRRQC------------------------------------ ------------------------------------------------------------ -------------VQQSLSGSFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------EYKAD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSE------------------------------------------- ---------------------------------------NPRG----------------- ------------------------------------------------------------ ---------------LSVLSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DESGSRIH RKNW-------------------------------------------------------- --------------------TLASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSVQKSSLCRNGSSLS-EG----D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AERDMGSKGGSW- ------------------------------------------------------------ ---AAPSSPSGVREDDPCANAEGRDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTVP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------EPSACS--------EPRE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RPAKKRLRLDGSQRPPAAQLE PR---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGDAPA----------PGP-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RESMTLRSTTRLGPPPSHA S----------------------------------------------------------- ----------------------VDETRRPP------------------------------ --------------------------------------------CPDSQ----------- --------------------------------------KLE--E-DCQ----S------- -----------------------------------------------SEASMGPNSVR-S VL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYKKYPFWPAV------ ------------------------------VKSVRQRDKKASVVYIEGHMNPK-RKGFTV SLKSLKHFDCKEKQTLLNQARVDYDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS CPVRKSIQQDLLGTRFPQLSRGSP-E--EPVVGSPLGQ-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDLVVKYLQGV-Y-QEVGAKVLRRTNGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDEVDYKTAEEKYIKGPS------------------------- -------------------LSYR----EKEIFDNQLLEERK---RRR-W----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSCSAP00000008342 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEYFLDVQILSLEEKIKVKSTEVEILEKS QIEAIASSL---ASQSEVPAAPLEELAYRRSLRVALDVLSEGPIWSQ-ESSAGTGRADQS LREKPTEHVSSPCDSNFSFLPRGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GPHRRRQC------------------------------------ ------------------------------------------------------------ -------------VQQSLSSSFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------ECKAD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSE------------------------------------------- ---------------------------------------NPRG----------------- ------------------------------------------------------------ ---------------LSVLSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DESGSRIH CKNW-------------------------------------------------------- --------------------TLASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSVQKSSLCRNGSSLS-EG----D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AERDMGSKGGSW- ------------------------------------------------------------ ---AAPSSPSGVREDDPCANAEGRDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTVP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------ETSASS--------EPRE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RPAKKRLRLDGSQRPPAAQLE PR---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGDAPS----------PGP-------- ------------------------------------------------------------ ----------------------------------EP------------------------ -----------------------------------------RESMTLRSITRLGPPPSHA S----------------------------------------------------------- ----------------------VDETRRPP------------------------------ --------------------------------------------CPDSQ----------- --------------------------------------KLE--E-DCQ----S------- -----------------------------------------------SEASMGSNSVR-S VL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYKKYPVWPAV------ ------------------------------VKSVRQRDKKASVLYIEGHMNPK-RKGFTV SLKSLKHFDCKEKQTLLNQAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDRLGTRFPQLSKGSP-E--EPVVGRPLGQ-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDLVVKYLQGV-Y-QEVGAKVLRRTNGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDEVDYKTAEEKYIKGPS------------------------- -------------------LSYR----EKEIFDNQLLEERK---RRR-W----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSPTEP00000034771 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEYFLDVQIVSLEEKIKVKSTEVEILEKS QIEAIASSL---ASQNEVPAAPLEELAYRRSLRVALDVLSEGPIWSQ-ESSAGTGRVNQP LREKPTEHVSSPCDSNFSSLPRGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GPHRGRQC------------------------------------ ------------------------------------------------------------ -------------VQQSLSSSFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------ECKAD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSE------------------------------------------- ---------------------------------------NPRG----------------- ------------------------------------------------------------ ---------------LSVLSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GESGSRIH RKNW-------------------------------------------------------- --------------------TLASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSVQKSSLCRNGSSLS-EG----D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AERDMGSKGGSW- ------------------------------------------------------------ ---AAPSSPSGVREDDPFANAEGRDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTVP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------EPSACS--------EPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RPAKKRLRLDGSQRPPAAQLE PR---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGDAPS----------PGP-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RESMTLRSTTRPGPPPSHA S----------------------------------------------------------- ----------------------VDESRRPP------------------------------ --------------------------------------------CPDSQ----------- --------------------------------------KLE--E-ACQ----S------- -----------------------------------------------SAASMGSDSMR-S VL-------EED------------------------------------------------ DEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWHKYKKYPFWPAV------ ------------------------------VKSVRQRDKKASVLYIEGNMNPK-KKGFTV SLKSLKHFDCKEKQTLLNQAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDVLGTRFPQLSKGSP-E--EPVVGRPLGQ-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDLVVKYLQGV-Y-QEVGAKVLRRTNGDRIRFILDVLLP-------ERRSRVGAVLSC QHWGCKL-------------------------------------PPHRGRTDAPRPRWVS LGKPTA------------------------------------------------------ ----------IICAISAVDEVDYKTAEEKYIKGPS------------------------- -------------------LSYR----EKEIFDNQLLEERK---RCR-W----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSPTRP00000061864 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLARTATSTKN--KRRKEYFLAVQILSLEEKIKVKSTEVEILEKS QIEAIASSL---ASQNEVPAAPLEELAYRRSLRVALDVLSEGSIWSQ-ESSAGTGRADRS LRGKPTEHVSSPCDSNSSSLPRGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------RPHRRRPC------------------------------------ ------------------------------------------------------------ -------------VQQSLSSSFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------ECKVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSE------------------------------------------- ---------------------------------------NPRG----------------- ------------------------------------------------------------ ---------------PLVLPA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DESGSRIH HKNW-------------------------------------------------------- --------------------TLASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSAQKASLCPNGSSLS-ED----D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TERDMGSKGGSW- ------------------------------------------------------------ ---AAPSLPSGVREDDPCANAEGHDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTAP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------EPSACS--------EPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CPAKKRPRLDGSQRPPAVQLE PM---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGAAPSP--------GPGP-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RESMTLRSTARLGPPPSHA S----------------------------------------------------------- ----------------------ADATRCLP------------------------------ --------------------------------------------CPDSQ----------- --------------------------------------KLE--K-ECQ----S------- -----------------------------------------------SEESTGSNSMR-S IL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWHKYKKYPFWPAV------ ------------------------------VKSVRQRDKKASVLYIEGHMNPK-MKGFTV SLKSLKHFDCKEKQTLLNQAREDFNQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTKFPQLSKGSP-E--EPVVGCPLGQ-RQPC--------RKMLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDVVVKYLQGV-Y-QEVGAKVLQRTNGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------CWEMRVRALDPVR RRSRLLDPCAEMELLRSCQHQG-------------------------------------- ---------------VRT-----------P--SPLRAHRCSPASVGHHLCDLCGGRGGLQ DG--------------------------------------------- >ENSPPAP00000006424 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLARTATSTKN--KRRKEYFLAVQILSLEEKIKVKSTEVEILEKS QIEAIASSL---ASQNEVPAAPLEELAYRRSLRVALDVLSEGSIWSQ-ESSAGTGRADRS LRGKPTEHVSSPCDSNSSSLPRGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------RPHRRRPC------------------------------------ ------------------------------------------------------------ -------------VQQSLSSSFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------ECKVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSE------------------------------------------- ---------------------------------------NPRG----------------- ------------------------------------------------------------ ---------------PLVLPA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DESGSRIH HKNW-------------------------------------------------------- --------------------TLASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSAQKASLCPNGSSLS-ED----D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TERDMGSKGGSW- ------------------------------------------------------------ ---AAPSLPSGVREDDPCANAEGHDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTAP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------EPSACS--------EPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CPAKKRPRLDGSQRPPAVQLE PM---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGAAPSP--------GPGP-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RESMTLRSTARLGPPPSHA S----------------------------------------------------------- ----------------------ADATRCLP------------------------------ --------------------------------------------CPDSQ----------- --------------------------------------KLE--K-ECQ----S------- -----------------------------------------------SEESTGSNSMR-S IL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWHKYKKYPFWPAV------ ------------------------------VKSVRQRDKKASVLYIEGHMNPK-MKGFTV SLKSLKHFDCKEKQTLLNQAREDFNQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTKFPQLSKGSP-E--EPVVGCPLGQ-RQPC--------RKMLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDVVVKYLQGV-Y-QEVGAKVLQRTNGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------CWEMRVRALDPVR RRSRLLDPCAEMELLRSCQHQG-------------------------------------- ---------------VRT-----------P--SPLRAHRCSPASVGHHLCDLCGGRGGLQ DG--------------------------------------------- >ENSGGOP00000021977 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLARTATSTKN--KRRKEYFLAVQILSLEEKIKVKSTEVEILEKS QIEAIASSL---ASQNEVPAAPLEELAYRRSLRVALDVLSEGSIWSQ-ESSAGTGRANRS LRGKPTEHVSLPCDSNSSSLPCGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------RPHRRRPC------------------------------------ ------------------------------------------------------------ -------------VQQSLSSSFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------S------- --------ECKVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSE------------------------------------------- ---------------------------------------NPRG----------------- ------------------------------------------------------------ ---------------PLVLPA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DESGSRMH HKNW-------------------------------------------------------- --------------------TLASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSAQKASLCPNGSSLS-ED----D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TERDMGSKGGSW- ------------------------------------------------------------ ---AAPSLPSGVREDDPCANAEGHDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTAP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------EPSACS--------EPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CPAKKRPRLDGSQRPPAVQLE P----------------------------------------------------------- ------------------------------------------------------------ -----------------------------------TAPSP--------GPRP-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RESMTLRSTARLGPPPFHA S----------------------------------------------------------- ----------------------ADATRCLP------------------------------ --------------------------------------------CPDSQ----------- --------------------------------------KLE--K-ECQ----S------- -----------------------------------------------SEESMGSNSMR-S ML-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWHKHKKYPFWPAV------ ------------------------------VKSVRQRDKKASVLYIEGHMNPK-MKGFTV SLKSLKHFDCKEKQTLLNQAREDFNQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTKFPQLSKGSP-E--EPVVGCPLGQ-RQPC--------RKMLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDLVVKYLQGV-Y-QEVGAKVLQRTNGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------CWEI-VRALDPVR RRSRLLDPCAEMELLRSCQHQG-------------------------------------- ---------------VRT-----------P--SPPPAHRCSPASVGHHLCDLCGGRGGLQ DGR-------------------------------------------- >ENSP00000498656 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLARTATSTKN--KRRKEYFLAVQILSLEEKIKVKSTEVEILEKS QIEAIASSL---ASQNEVPAAPLEELAYRRSLRVALDVLSEGSIWSQ-ESSAGTGRADRS LRGKPMEHVSSPCDSNSSSLPRGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------RPHRRRPC------------------------------------ ------------------------------------------------------------ -------------VQQSLSSSFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------ECKVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSE------------------------------------------- ---------------------------------------NPRG----------------- ------------------------------------------------------------ ---------------PLVLPA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DESGSRIH HKNW-------------------------------------------------------- --------------------TLASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GNSAQKASLCLNGSSLS-ED----D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TERDMGSKGGSW- ------------------------------------------------------------ ---AAPSLPSGVREDDPCANAEGHDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTAP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------EPSACS--------EPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CPAKKRPRLDGSQRPPAVQLE PM---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGAAPSP--------GPGP-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RESVTPRSTARLGPPPSHA S----------------------------------------------------------- ----------------------ADATRCLP------------------------------ --------------------------------------------CPDSQ----------- --------------------------------------KLE--K-ECQ----S------- -----------------------------------------------SEESMGSNSMR-S IL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWHKHKKYPFWPAV------ ------------------------------VKSVRQRDKKASVLYIEGHMNPK-MKGFTV SLKSLKHFDCKEKQTLLNQAREDFNQDIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTKLPQLSKGSP-E--EPVVGCPLGQ-RQPC--------RKMLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDLVVKYLQGV-Y-QEVGAKVLQRTNGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDEVDYKTAEEKYIKGPS------------------------- -------------------LSYR----EKEIFDNQLLEERN---RRR------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSNLEP00000032204 M-----------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEHFLDVQILSLEEKIKVKSTEAEILEKS QIEAIASSL---ASQNEVPAAPLEELAYRRSLRVALDVLSDGPVWSQ-ESPAGTGRANRS LRGKPMEHVSSPCDSNSSPLPRGDVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------RPHRRRPC------------------------------------ ------------------------------------------------------------ -------------VQQSPSSSFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------ECIVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRRSE------------------------------------------- ---------------------------------------NPRG----------------- ------------------------------------------------------------ ---------------PSVLPA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGAQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DESGSRIH HRNW-------------------------------------------------------- --------------------TPASKKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GNSAQKASLCPSGSSLS-ED----D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AERDVGSKGGSW- ------------------------------------------------------------ ---AAPSLPSGVREDDPCANAEGRDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTVL-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------EPLACS--------EPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CPAKKRLRLDGSQRPPAGQLE PR---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGAAPSP--------GPGS-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RECMTLRSTARLGPPPSHT S----------------------------------------------------------- ----------------------VGETRCPP------------------------------ --------------------------------------------CPDSQ----------- --------------------------------------KLE--K-DCQ----S------- -----------------------------------------------SEESMGSNSMR-S IL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRVLLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYKKYPSWPAV------ ------------------------------VKSVRQRDKKASVLYIEGHMNPK-MKGFTV SLKSLKHFDCKEKQTLLSQAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTKFPQLSKGSP-E--EPVVGWPLGQ-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQSFLNSSQYVTCVETYLEDE GQLDLVVKYLQGV-Y-QEVGAKVLRRTNGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDEVDYKTAEEKYIKGPS------------------------- -------------------LSYR----EKEIFDNQLLEERN---RRR------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSANAP00000018047 M-----------------------------------------------------MA-DA- KFVLCRWEKRLWPAKVLARTKTSTKN--KRKKEYFLDVQILSLEEKIQVRSTEVEILEKS HIEAIASSL---ASQNEVPAAPLEELAYRRSLRVALDVLSEGLVWSQ-ESSRDTGRAERS RRGKPTEPISSPCDSSSWS-PGGGVLGSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GPHGRREC------------------------------------ ------------------------------------------------------------ -------------VQQSLSRPFTCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------T------- --------KCKVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSD------------------------------------------- ---------------------------------------NPRG----------------- ------------------------------------------------------------ ---------------LSVFSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGSQSRMH RKNR-------------------------------------------------------- --------------------TLTSKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNLAQKSSLRPSGSSLS-ES----D-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AEEDSGSKAGRW- ------------------------------------------------------------ ---AAPASPSRVREDDPCANAEGRNP---------VLPS--------------------- ------------------------------------------------------------ ------------------GSLTVP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------EPSACS--------EPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CPAKKRPRLDGSQRLPAVQLE PR---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGAAPS----------PGPE------- ------------------------------------------------------------ ---------------------------------VGP------------------------ -----------------------------------------RESVTLRNTASLRPPPSHA P----------------------------------------------------------- ----------------------VDETRRPR------------------------------ --------------------------------------------L-ESQ----------- --------------------------------------ELE--E-DCQ----S------- -----------------------------------------------SEASMRSNSMR-S IL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGDMNPK-GKGITV SLRRLKHFDCKDKQTLLNQAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTKFPQLSKGSP-E--EPVLGSPLGQ-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDE GQLDLVVKYLQGV-Y-QEVGAKALRRTNGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDEVDYRTAEEKYMKGPS------------------------- -------------------LSYR------------------------------------- ---------------------GLMFAFGTVLPSVCS------------------------ ------------AMAV-------------------------------------------- ----------------------------------------------- >ENSPCOP00000007780 I-----------------------------------------------------ME-DA- KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEFFLDVQILSLEEKIKVKSTDAEVLRKS QIEAIASSL---ASQNEAPAAPLEELTYRRSLRVALDVLSERASSSQ-E----------- --------------------------GSSRTG---------------------------- -------------------------------------------------------GTAL- ------------SR-RGKQPTELAPSLCD------------------------------- ------------------------------------------------------------ ------------ADCCPPQGRKEY------------------------------------ ------------------------------------------------------------ -------------APQSLSGPSPCEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------QCRVN-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLRKSA------------------------------------------- ---------------------------------------YPGG----------------- ------------------------------------------------------------ ---------------LPAPAA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GDGSS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGSRARVH GRDW-------------------------------------------------------- --------------------TVTSKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSAQKPSPCQKVPLPS-E-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GEN------------------- --------------------------------------------GRESER----KAGGW- ------------------------------------------------------------ ---AAPSPPCRVREDDPCARAEGRDP---------GLPS--------------------- ------------------------------------------------------------ ------------------GSLTVP-AA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------DHLSCS--------EAGE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CPT-KRPCLDGCQRPPATRLE MG---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAGPELS----------PRQ-------- ------------------------------------------------------------ ----------------------------------GL------------------------ -----------------------------------------RERMTLRSAARPGQPPPHA P----------------------------------------------------------- ----------------------AEDTRSLR------------------------------ --------------------------------------------LPDSR----------- --------------------------------------KLE--E-DLQ----S------- -----------------------------------------------SEESMEFSSIN-S IL-------EED------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVKRRDKKASVLFIEGDMNPK-GRGITV SLRRLKHFDCKEKQTLLNKAREDFDQAIGWCVSLITDYRVRLGCGSFTGSFLEYYAAHIS YPVRKSIQQDALGTRFPKLSLGDP-K--EPEVDSALGW-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------SHLRAVLKSKRPSRWLETFLSSSQPVTCVETYLEDE EQLDLVVKYLQGV-C-QEMGSTVLTRTHGDRIRFVLDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYIKGPS------------------------- -------------------LSYR----EKEIFDNQLLEERS---RRC------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSMICP00000003552 ------------------------------------------------------ME-DA- KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEFFLDVQILSLEEKIKVKSTDVEVLRKS QIEAIAASLVCAASQNEVPAAPLEELTYRRSLRVALDVLSERASLSQ-E----------- --------------------------GSSRTG---------------------------- -------------------------------------------------------GTAP- ------------SQ-WRKPPTEPAPSLCD------------------------------- ------------------------------------------------------------ ------------ADCPPPQGRREC------------------------------------ ------------------------------------------------------------ -------------ALQSLSGPSPCKKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------QCSAN-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLGKSA------------------------------------------- ---------------------------------------HPGG----------------- ------------------------------------------------------------ ---------------LPAPAA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------RDGSR----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------AGSGATVH GRDR-------------------------------------------------------- --------------------TLASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNTVQKPSLCQKVPSPS-E-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GEN------------------- --------------------------------------------GKESER----KAGSW- ------------------------------------------------------------ ---TAPSPPCRVREDDPCARAEGRDP---------GLPS--------------------- ------------------------------------------------------------ ------------------GSLTVP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------ARSACS--------ETGE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------HPA-KRPCLDGSQRPPATPLE MG---------------------------------------------------------- ------------------------------------------------------------ --------------------------------TTGPELS----------PRQ-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RERMTLRSAARPGQPAPHA P----------------------------------------------------------- ----------------------AEDARSLR------------------------------ --------------------------------------------LSDSR----------- --------------------------------------KLE--E-DLQ----S------- -----------------------------------------------SEESMEFSSIN-S IL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGDMDPK-GRGITV SLRRLKHFDCKEKQALLNKAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAAHIS YPVRKSIQQDALGTRFPQLSRGDP-K--EPEVDSALGW-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------SHLRAVLKSRRPSRWLETFLSSSQPVTCVETYLEDE EQLDLVVKYLQGV-C-QEMGSTVLTRTHGDRIRFVLDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYIKGPS------------------------- -------------------LSYR----EKEIFDNQLLEERS---RRC------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------W >ENSOGAP00000003037 ------------------------------------------------------MA-DA- KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEFFLDVQILSLEEKIKVRSTEVEVLKKS QIEAIAASLVLSASQNEVPAAPLEELTYRRSLRVALDVLNERTSVSQ-E----------- --------------------------GSSRTE---------------------------- -------------------------------------------------------GTAL- ------------SQ-REKQPVEPNSLLCD------------------------------- ------------------------------------------------------------ ------------SNCTGPQGRREC------------------------------------ ------------------------------------------------------------ -------------TPQSPSGLSTYEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------NYKVN-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KELRKSA------------------------------------------- ---------------------------------------RPRG----------------- ------------------------------------------------------------ ---------------LSVSST--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------FDGSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGSGSRVH GENY-------------------------------------------------------- --------------------TIASKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSAQKSSLCQNVPSLS-EA----DY------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------EKKASSCTTLFL----------------- ------------------------------------------------------------ ---PT------------------------------CVSGE-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------DPCARAREWNP---------GLPS--------------------- ------------------------------------------------------------ ------------------GSVTIP-AA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------VHLAYS--------EAGE------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CPV-KRPC--------TKQLE TG---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAEPELS----------PRH-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RECMTLRSTTRLGPPP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------LQASTDS------- -----------------------------------------------SEESMEFNSIN-S IL-------DED------------------------------------------------ EDDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGDMNPK-GRGITV SLRRLKHFDCKEKQTLLNKAREDFDQAIGWCVSLITDYRVRLGCGSFSGSFLEYYAADIS YPVRKSIQQDALGTRFPQLSKGSS-E--EPEAVSALGR-RLPC--------RKVLPDRSR AARDRANQKLVEYIVKARGTE--------------------------------------- ------------------------SHLRAILKSRRPSRWLETFLSSSQAMTCVETYLEDE EQLDLVVKYLQGF-C-QELGGPVLTRAHSDRIRFVLDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYIKGPS------------------------- -------------------LSYR----EKEMFDNQLLEERN---RRH------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSSDAP00000006833 I-----------------------------------------------------MT-DA- KYVLCRWERRLWPAKVLARTETSTKN--KRKKEFFLDVQILSLEEKLSVKSTEVEALQKS QIENIASFL---ASQEEVPAAPLEELTYRRSLRVALDVLNERDRICQ-E----------- --------------------------GPSRREQLP-----TGVASL-------------- -----------P-----RDILSPSFLPERRWE----------------------YA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------QHDLSGLFTCEKA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------NCKVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KELRKSE------------------------------------------- ---------------------------------------NPRA----------------- ------------------------------------------------------------ ---------------QSVSPT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SDGCQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGSRSRNH RSSR-------------------------------------------------------- --------------------MRASKRR--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSAPKSTWC----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------HGVPALPGAGLEEESQG- ------------------------------------------------------------ --EP-------------------------------------------------------- --------------------------------------------------------GCW- ------------------------------------------------------------ ---MALSSPSRAREDDPCARAEGRDP---------GLPS--------------------- ------------------------------------------------------------ ------------------GSLTVP-PA--QEEA------------------------GGH LMKRLCLDGGRRLQTAQPEPAASGAALPPS------------------------------ ------------------------------------------------------------ ----QGPCA------------DPCAER--------------SRGDSLISLLADPP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------S------- -----------------------------------------------SEESMECGSIN-S IL-------DAD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PSSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSIRRRDKKASVLFIEGDMNPK-GRGITV PLRRLKHFDCEEKQALLDKAKEDFDRDIGSCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDILGTRFPQLNKGDL-E--EPVEGSTAGR-RQPC--------RKVLPDRSR AARDRANQRLVEYIVKTRGAE--------------------------------------- ------------------------SHLQAILRSRRPSRWLKTFLSSSQYVTCVETYLEDE EQLDLVVKYLQGL-Y-QQMDGEVLAGVNGDSIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYIKGPS------------------------- -------------------LSYR----EKEIFDNQLLEERN---RR-------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSUPAP00010016854 ------------------------------------------------------MT-DA- KYVLCRWERRLWPAKVLARTETSTKN--KRKKEFFLDVQILSLEEKIQVKSTEVEALQKS QIENIASFL---ASQEEVPAAPLEELTYRRSLRVALDVLNERDRICQ-E----------- --------------------------GPSRREQLP-----TGVASL-------------- -----------P-----RDILSPSFLPERRWE----------------------YA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------QRDLSGLFTCEKA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------NCKVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KELRKSE------------------------------------------- ---------------------------------------NPRA----------------- ------------------------------------------------------------ ---------------QSVSPA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SDGCQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGSRSRNH RSSR-------------------------------------------------------- --------------------TRASKRR--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSAPKSTWC----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------QGVPALPGSGLEEESQG- ------------------------------------------------------------ --EP-------------------------------------------------------- --------------------------------------------------------GCW- ------------------------------------------------------------ ---MALSSPSRAREDDPCARAEGRDP---------GLPS--------------------- ------------------------------------------------------------ ------------------GSLTVP-PA--QEGA------------------------GGC LMKRLCLDGGRRLQTAQLEPAASGAALPPSSTPAEEA----------------RHPGLQA -----------------------------------------------------------H GQLEQ-----------------------------------------------DPP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------S------- -----------------------------------------------SEESMECGSIN-S IL-------DAD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PSSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSIRRRDKKASVLFIEGDMNPK-GRGITV PLRRLKHFDCEEKQALLDKAKEDFDRDIGSCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLNKGDL-E--EPVEGSTXGR-RQPC--------RKVLPDRSR AARDRANQRLVEYIVKTRGAE--------------------------------------- ------------------------SHLQAILRSRRPSRWLKTFLSSSQYVTCVETYLEDE EQLDLVVKYLQGL-Y-QQMDGEVLAGVNGDSIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYIKGPS------------------------- -------------------LSYR----EKEIFDNQLLEERN---RR-------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSUAMP00000018502 ------------------------------------------------------MT-DA- QYVLCRWEKRLWPAKVLARTEMSTKN--KRKKEFFLSVQILSLDEKIEVRSTDVETLKTA HIERIASSL---ASENEVPAEPLEELAYRRSLRVALDVLNQRSSLPQ-E----------- --------------------------TSSGEE---------------------------- -------------------------------------------------------RTAL- ------------SS-GER-PMKLASSLCDPSSSGLREDVPS------------------- ------------------------------------------------------------ NCGPPRRERVRPR----------------------------------------------- ------------------------------------------------------------ -----------------LSGSPPCRKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------KCKVD-------------------------------HR-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KALGKNE------------------------------------------- ---------------------------------------SPRA----------------- ------------------------------------------------------------ ---------------LVVPSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------RGGSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGSGSRMC RRRR-------------------------------------------------------- --------------------MAPSKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RHLAQEPSWCQRGPSLS-EG----DS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ETES----------------- --------------------------------SPA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APRSPPCVREEGLW--AKGRDP---------GLPL--------------------- ------------------------------------------------------------ ------------------SGPTVL-PT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------S----- -----------------------------------GRPTC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PDARGRPA-KRLCPDGSQRPPATQLG PG---------------------------------------------------------- ------------------------------------------------------------ --------------------------------VA---------------PRQ-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------GGGMTLRSAAKRS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------LPAPRASTEETRNLRFLPEEGE-DRQ----S------- -----------------------------------------------SGESVEFSPIR-S IL-------EED------------------------------------------------ EDDEE------------------------------------------------------- ---------------------------------------------PPRILFYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKHQKYPFWPAV------ ------------------------------VKSVRRREKKASVLFIEGHMDPK-GRGITV SLKRLKHFDCKEKQALLNEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGDP-E--EPVVGSPQRK-RRPY--------RKVLPDRSR AARDRANQKLVEYIVKARGTE--------------------------------------- ------------------------GHLRAILKNRKPSRWLKTFLNSGQYMTCVETYLEDE EQLDLVVKYLQGV-Y-QETGSRTLARINGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAIAAVDAVDYKTAEEKYLKGPS------------------------- -------------------LSYR----EKEIFDNQLLEERS---QRC------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSAMEP00000003492 ------------------------------------------------------MT-DA- QYVLCRWEKRLWPAKVLARTETSTKN--KRKKEFFLSVQILSLDEKIEVRSTDVETLKTA HIERIASSL---ASENEVRAEPLEELAYRRSLRVALDVLNQRSSLPQ-E----------- --------------------------TSSGEE---------------------------- -------------------------------------------------------RTAL- ------------SS-GEK-PMELASSLCDPSSSGLREDVPS------------------- ------------------------------------------------------------ SCGPPRRERVRPR----------------------------------------------- ------------------------------------------------------------ -----------------LSGSPACRKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------KCKVD-------------------------------HR-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KALGKNE------------------------------------------- ---------------------------------------SPQA----------------- ------------------------------------------------------------ ---------------LVVHSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------RGGSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGSGSRMC RRRR-------------------------------------------------------- --------------------TAPSKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RRLAQEPSWCQRELSLS-EG----DS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ETES----------------- --------------------------------SPA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APRSPPCVREEGLW--AEGRDP---------GLPL--------------------- ------------------------------------------------------------ ------------------SGPTVL-PT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------GRPTC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PDARGRPA-KR---------PATQLG PG---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AA---------------PRQ-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------GGGMTLRSAAKRS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------LPAPRASTEETRNLRFLLE--E-DRQ----S------- -----------------------------------------------SGESVDFNPIR-P TL-------EED------------------------------------------------ EDDEE------------------------------------------------------- ---------------------------------------------PPRILFYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKHQKYPFWPAV------ ------------------------------VKSVRRREKKASVLFIEGHMDPK-GRGITV SLRRLKHFDCKEKQALLNEAKVDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGDP-E--EPVVGSPQGR-RRPY--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------GHLRAILKNRKPSRWLKTFLNSGQYLTCMETYLEDE EQLDLVVKYLQGV-Y-QETGSRTLARINGDRVRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAIAAVDAVDYKTAEEKYLKGPS------------------------- -------------------LSYR----EKEIFDNQLLEERS---QR-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSVVUP00000031405 ------------------------------------------------------MT-DA- QYVLCRWEQRLWPAKVLARTEMSTKN--KRKKGVFLSVQILSLDEKIEVRSTEVEILKTA HIERIASSL---ASQGEVPAEPLEELAYRRSLRVALDVLNQRTGLPP-E----------- --------------------------SSSREE---------------------------- -------------------------------------------------------RTAL- ------------SS-REK-PTELASSLCDPGSSCLREDVPS------------------- ------------------------------------------------------------ SSGPQRRDRVHPR----------------------------------------------- ------------------------------------------------------------ -----------------LSGSPTCRKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------KGKVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KELGKSG------------------------------------------- ---------------------------------------SLQA----------------- ------------------------------------------------------------ ---------------LVVPSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------RGGSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGGGSRTC CRSR-------------------------------------------------------- --------------------TTPSKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNLAQEPSLCQRAPSLS-EG----DG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KSLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TSGSPPRVREKGLC--AKGEDP---------GLPW--------------------- ------------------------------------------------------------ ------------------CGPAVL-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------GRPAC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PDARGRPA-KRPCPDGSQRLPATQLE PG---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAP-------------CPRQ-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RGRMTLRSAAKLG------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------LPAPCASTEET-NLHILVE--E-DRQ----S------- -----------------------------------------------SGDSMEFNPIH-S IL-------EED------------------------------------------------ EDDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKHQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGHMDPK-GRGITV SLKRLKHFDCKEKQELLNEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKEDP-E--EPVAGSPQGR-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------GHLRAILKNRKPSRWLNTFLSSGQYMTCVETYLEDE EQLDLVVKYLQGV-Y-QETGSRTLARVNGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAIAAVDAVDYKTAEEKYLRGPS------------------------- -------------------LGYR----EKEIFDKQLLEERS---QRC------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSCAFP00000028879 ------------------------------------------------------MT-DA- QYVLCRWEQRLWPAKVLARTETSTKN--KRKKGVFLSVQILSLDEKIEVRSTEVEILKTA HIERIASSL---ASQGEVPAEPLEELAYRRSLRVALDVLNQRTGLPP-E----------- --------------------------SSSREE---------------------------- -------------------------------------------------------RTAL- ------------SS-REK-PTELASSLCDPSSSCLREDVPS------------------- ------------------------------------------------------------ SSGPQRRERVHPR----------------------------------------------- ------------------------------------------------------------ -----------------LSGSPTCRKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------KGKVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KELGKSG------------------------------------------- ---------------------------------------SPQA----------------- ------------------------------------------------------------ ---------------LVVPSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------RGGSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGGGSRTC CRSR-------------------------------------------------------- --------------------TTPSKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RSLAQEPSLCQRAPSVS-EG----DG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- --------------------------------SLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TSGSPPRVREKGLC--AKGEDP---------GLPW--------------------- ------------------------------------------------------------ ------------------CGPAVL-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------GRPAC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PDAQGRPA-KRPCPDGSQRLPATQLE PG---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AAP-------------CPRQ-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RGRMTLRSAAKLG------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------LPAPCASTEET-NLHILVE--E-DRQ----S------- -----------------------------------------------SGDSMEFNPIH-S IL-------EED------------------------------------------------ EDDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKHQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGHMDPK-GRGITV SLKRLKHFDCKEKQELLNEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKEDP-E--EPVAGSPQGR-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------GHLRAILKNRKPSRWLNTFLSSGQYMTCVETYLEDE EQLDLVVKYLQGV-Y-QETGSRTLARVNGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAIAAVDAVDYKTAEEKYLRGPS------------------------- -------------------LGYR----EKEIFDKQLLEERS---QRC------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSPPRP00000018805 V-----------------------------------------------------MT-DA- KYVLCRWEKRLWPAKVLARTEVATKN--KRKKEFFLSVQILSLDEKIEVRSTEVEALRVA HIERIASTL---ASQNEVPAEPLEELAYRRSLRVALDVLNESTGLPQ-E----------- --------------------------SPSREE---------------------------- -------------------------------------------------------RTAL- ------------CS-REK-PMELASLLCGPASSCVQEAVPG------------------- ------------------------------------------------------------ RSGPERRERVHPR----------------------------------------------- ------------------------------------------------------------ -----------------LSGSPTCQKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------KCKVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KELRKSG------------------------------------------- ---------------------------------------SPQA----------------- ------------------------------------------------------------ ---------------LVVPPA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------RGGSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------HGSGSRTC CASR-------------------------------------------------------- --------------------TTPSKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RSSAREPAVGQSAPSLS-EG----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------E-ES----------------- --------------------------------RLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APRSPPTVKEEGLW--AKGRDP---------SLPL--------------------- ------------------------------------------------------------ ------------------PGPTGS-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------GRPAC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PDAQGLPA-KRPCPDSGQRPPAARLE PG---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AVA-------------SPRQ-------- ------------------------------------------------------------ ----------------------------------GP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GK------ ---------CRALPGAARLHLPAPL-----------SNLMPLAARPTSGESVERVPIR-S VL-------DEE------------------------------------------------ EDEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKHQKYPFWPAV------ ------------------------------VKSVRRREKKASVLFIEGHMDPK-GRGITV SLRRLKHFDCKEKQELLNEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGDP-E--EPVTGSPQGR-RRPR--------RKVLPDRSR AARDRANQKLVEYIVKARGAEGHLRAILRNRKPSRWLKTFLNSGQYVTCVETYLEDEEQL DLVVKYLQGVYQETGSRALARGAGGHLRAILRNRKPSRWLKTFLNSGQYVTCVETYLEDE EQLDLVVKYLQGV-Y-QETGSRALARINADRIRFVLDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAIAAVDAVDYETAEAKYLRGPS------------------------- -------------------LSYR----EKEMFDNQLLEERS---QRC------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSFCAP00000008744 V-----------------------------------------------------MT-DA- KYVLCRWEKRLWPAKVLARTEVATKT--KRKKEFFLSVQILSLDEKIKVRSTEVEALKMA HIERIASTL---ASQNEVPAEPLEELAYRRSLRVALDVLNESTGLPQ-E----------- --------------------------SPSREE---------------------------- -------------------------------------------------------RTAL- ------------GS-REK-PVELASLLRDPASSCVQEAVPD------------------- ------------------------------------------------------------ RSGPERRERVHPR----------------------------------------------- ------------------------------------------------------------ -----------------LSGSPTCQKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------RCKVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KELRKSA------------------------------------------- ---------------------------------------SPQA----------------- ------------------------------------------------------------ ---------------LVVPPA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------RGGSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGRGSRTC CASR-------------------------------------------------------- --------------------TTPRKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RSVAREPAVGQSAPSVS-EG----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------E-ES----------------- --------------------------------RLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APGSPPTVKEEGLW--ARGRDP---------SLPL--------------------- ------------------------------------------------------------ ------------------PGPTGP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------GRPAC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PDAQGLPA-KRPRPDSGQRPPAARLE PGGSGVPQA-------------------------------GAR------EMQGSARRC-- ---------------------------------------------------------QTP PACPPVS------------------------S---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------LMPLAARPTSGESVERAPVR-S VL-------EEE------------------------------------------------ EDEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKHQKYPFWPAV------ ------------------------------VKSVRRREKKASVLFIEGHMDPK-GRGITV SLRRLKHFDCKEKQELLNEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSNGDP-E--EPVAGSPQGR-RRPR--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------GHLRAILRNRKPSRWLKTFLNSGQYVTCVETYLEDE EQLDLVVKYLQGV-Y-QETGSRALARINADRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAIAAVDAVDYETAEAKYLRGPS------------------------- -------------------LSYR------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSMPUP00000008267 ------------------------------------------------------MT-DA- QYVLCRWEQRLWPAQVLARTETSTGS--KRKKEFSLSVQILSLDEKIEVRSTDVETLKTA HIERIASSL---ASQDAVRAEPLEELAYRRSLRVALDVLNQRAALPR-E----------- --------------------------SSSREG---------------------------- -------------------------------------------------------RTAL- ------------SS-GGK-SADPASSLCDPGSSGLQEAVPS------------------- ------------------------------------------------------------ SSGLQRRERAHPR----------------------------------------------- ------------------------------------------------------------ -----------------LVAAPACRQDSRRQVAHKEELGKSESL---------------- -----------------------------------------RAVAGPSARAASRQGSGSR ARCR---------------RRT-------------------------------------- ------------------APRPRGRKLAPEPGLGERARALSEGAGGK-ESSPP------- --------R--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----PRSPPGVREEGLW--AKARDP---------GLPLHSPD----------------- ------------------------------------GLP--------------------- ---------------TLE------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RPA-KRLCPDGSQRLPAPQLE PG---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AV---------------PRQ-------- ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RGCTGLRSAGELG------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------LPGPRAAEEPR-DLHILVE--E-DRQ----S------- -----------------------------------------------SGESVELNPIR-S VL-------EED------------------------------------------------ EDDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKHQKYPFWPAV------ ------------------------------VKSVRRREKKASVLFIEGHMDPK-GRGITV SLRRLKHFDCKEKQALLNEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGDP-E--EPVAGSPQGR-RRPY--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------GHLRAILKNRKPSRWLKTFLASGQYVTCVETYLEDE QQLDVVVKYLQGL-Y-QEAGGRAPARASGDTIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAIAAVDAVDYKTAEEKYLRGPS------------------------- -------------------LSYR----EKEIFDNQLLEERN---QRC------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSEASP00005031817 ------------------------------------------------------MT-DA- KYVLCRWKKRLWPAKVLARPEASTKN--KRKKEFFLNVEIISLDKKIRVKSTRVKILKKF HIEDIASSL---ASQHEVPAEALEELAYRRSLRVALDVLNERTSCHR-E----------- --------------------------SSSREA---------------------------- -------------------------------------------------------RT-V- ------------SP-REK-PTELVSLLCDSS--------PSSLLH--------------- -------------------------------------------------------KGMSG SFGPHRRERGCQR----------------------------------------------- ------------------------------------------------------------ -----------------LSGSPAHEED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------KCQVD-------------------------------PK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLGKSE------------------------------------------- ---------------------------------------SPRA----------------- ------------------------------------------------------------ ---------------PAASSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGRGSRIR QGDP-------------------------------------------------------- --------------------MTPRKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSAHSP--CQNAPSLP-EG----DP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------ETRA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APCSPSRVKEEGPG--AEGRDP---------ALPA--------------------- ------------------------------------------------------------ ------------------GGPTLL-LA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------G---C-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PQARGCPS-RQQCPDGSQRP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RGCMSLRSTAKPS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PPPPRVPTEEAGSLQ-PLE--E-DRP----S------- -----------------------------------------------SEESVQFNSVN-S IL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPK-GKGITV CLRRLKHFDCKEKHALLSEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGHE-E--EPAAGSPQGR-RPPC--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------SHLRAILRDRKPSRWLQTFLNSGQYMTCMETYLEDE EQLDLVVKYLQGL-F-QETGSRMLARINGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----ASGWPGRFCAARVGVCSEGPGTGQLGAGTSVSVEPGHPVGLNLLAVVGGQELHAP PACSRGTRSGI------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSECAP00000020407 ------------------------------------------------------MT-DA- KYVLCRWKKRLWPAKVLARPEASTKN--KRKKEFFLNVEIISLDKKIRVKSTRVKILKKF HIEDIASSL---ASQHEVPAEALEELAYRRSLRVALDVLNERTSCHR-E----------- --------------------------SSSREA---------------------------- -------------------------------------------------------RT-V- ------------SP-REK-PTELVSSLCDPS--------PSSLLH--------------- -------------------------------------------------------KGMSG SFGPHRRERGCQR----------------------------------------------- ------------------------------------------------------------ -----------------LSGSPAHEED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------KCQVD-------------------------------PK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLGKSE------------------------------------------- ---------------------------------------SPRA----------------- ------------------------------------------------------------ ---------------PAASSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGRGSRIR RGDP-------------------------------------------------------- --------------------MTPRKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSAHSP--CQNAPSLP-EG----DP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ERES----------------- -------------------------------EARA------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APCSPSRVKEEGPG--AEGRDP---------ALPA--------------------- ------------------------------------------------------------ ------------------GGPALL-LA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------G---C-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PQARGCPS-RQQCPDGSQRP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------GP------------------------ -----------------------------------------RGCMTLRSTAKPG------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------LPPPRVPTEEAGSLQ-PLE--E-DRP----S------- -----------------------------------------------SEESVQFNSVN-S IL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPK-GKGITV CLRRLKHFDCKEKHALLSEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGHE-E--EPAAGSPQGR-RPPC--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------SHLRAILRDRKPSRWLQTFLNSGQYMTCMETYLEDE EQLDLVVKYLQGL-F-QETGSRMLARINGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYIKGPS------------------------- -------------------LSYR----EKQIFDNQLLEERS---RRS------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSMLUP00000003101 I-----------------------------------------------------MT-DA- KYVLCRWKERLWPAKVLARTEMST-T--KKKKRFFLNVQILSLDKKVRVKSTEAKILRKS HIEDIAALL---ASQNKVSAKPVEELTYRRSLRVALDILNEKTHSHQ-E----------- --------------------------NSSREE---------------------------- -------------------------------------------------------RTAV- ------------SA-GEK-HMELASSLCDPN--------PSSLLH--------------- -------------------------------------------------------EGVLG SSGSERRLRGHQK----------------------------------------------- ------------------------------------------------------------ -----------------LSGSSTSENE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------I------- --------KCQMD-------------------------------NK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGVGENE------------------------------------------- ---------------------------------------SPLI----------------- ------------------------------------------------------------ ---------------RVV-SA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GGGSR----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DRSGSRIH LKNG-------------------------------------------------------- --------------------TTLSKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNLAQEPSRCQNGSSLS-VG----DQ------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ERES----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EEKTDSSAVLSSPSAAM- ----------------------------------EQGL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------CA--------KGRH------- ------------------SV-SP------------------------------------- ------------------------------------SGSPTVHP---------------- ------------------------------------------------------------ --------------------------------AYPDVHGPPG-KQLCSGGSQRS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------GL------------------------ -----------------------------------------RGCMTLGSTSRLGP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------SILLTP------ -----------------SDNTSLP--------------VLE--E-DHQ----S------- -----------------------------------------------SEESMEFDPVN-S IL-------EED------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PSSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKNVKRREKKASVLFIEGHMDPK-GRGITV PLKRLKHFDCKEKQALLNEAKEDFDQAIGWCVSLITDYRVRLGCGSFSGSFLEYYAANIS YPVRKSIQQDVLGTRFPRLCHEDP-E--MPLAGSPWGR-RQPC--------RKVLPDRSR AARDRANQKLVEYIVKTRGAE--------------------------------------- ------------------------NHLRAILKNRKPSRWLQTFLNSGQYVTCVETYLEDE EQLDLVVKYLQGV-Y-RETGSRMLTQINGDQIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDKVDYKTAEKKYIKGPL------------------------- -------------------LSYR----EKEMFDNQLLEERN---QR-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSDNOP00000032964 I-----------------------------------------------------MM-DA- KYVLCRWKKRLWPAKVLFRSEMSTKN--KRKKEFFLDVQILSLDEKIKVKSTEVKILKKS QIEDIASLL---ATQNKVTASPLEELAYRRSLRVALDVLNERARSNQ-E----------- --------------------------SSSREE---------------------------- -------------------------------------------------------RTAL- ------------SQ-SEK-PVEPASSLSNSH--------FSSFFH--------------- -------------------------------------------------------EDRSG SSG--------------------------------------------------------- ------------------------------------------------------------ -------------------------------------------LEGGESGQQSLSSSPAC KEELPGRACLRKERGERDTPRALLFSSVGDGPRDSIGSGILQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KNW-------------------------------------------------------- --------------------TNSSKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSAQKSGLCQNVPSLS-GGTCEIDR------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKET----------------- ----------------------------------------------------------GN SAAAS--------------------------------------SPPEAGEEAARAEVGGD PVRPS------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSLAVL-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RRRKADDPHHGTRACPRW----------P----- ---------------------------------------C-------------------- ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ -----------------------GARARSP-------------KRLCPDSSQRPPAWEGE MG---------------------------------------------------------- ------------------------------------------------------------ --------------------------------AARP-------------PRR-------- ------------------------------------------------------------ ----------------------------------GS------------------------ -----------------------------------------RGRMTLRSVSRRG-PPLHT P----------------------------------------------------------- ----------------------ADRTGDLR------------------------------ --------------------------------------------CLGSE----------- --------------------------------------RAE--E-DHQ----S------- -----------------------------------------------SGESVEFNSMN-S LL-------EED------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVKRREKKASVLFIEGNMNPK-GKGFTV SLRRLKHFDCKEKQILLDKAREAFSQAIGWCISLITDYRVRLGCASFTGSFLEYYAADIS YPVRKSIQQDVLGTKFPQLSKGDP-N--EPVEGTPLGKGRQPH--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILRSRKPSRWLTTFLNSSQYVTCVETYLEDE EQLERVVKYLQGV-Y-QETDSRVLTRINGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDEVDYKTAEEKYIRGPS------------------------- -------------------LSYR----EKEIFDNQLLEERS---RRR------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSODEP00000016891 ------------------------------------------------------MT-DA- KYVLCRWEERLWPAKVLDGPKTSTND--KGRKEFFLDVQILSLDEKLSVKSTEVETLNKS QIESIASSL---ALQTEVPTAALQELTYRRSLRVALDVLNEGSGLSW-E----------- --------------------------STSRRN---------------------------- -------------------------------------------------------GSAW- ------------WR-REKEPTEAASSL---------------------RNTLHSSFREDV SAHPG------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EKE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------EVKVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KRPGKSE------------------------------------------- ---------------------------------------TPGA----------------- ------------------------------------------------------------ ---------------LLAP----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------AGPQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGS----- -------------------------------------EWD-------------------- -----------------AGHTLTRKRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RSLAQRSGQCQE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------APAPSGAQSEEQCVGQ A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------SLPQAQEDDLCAQAEGHDP---------GLPL--------------------- ------------------------------------------------------------ ------------------GSLTVV-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------L----- -----------------------------------DR----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGGPPA-KRMHL----RLPATQLE PELS-------------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------PKP-------- ------------------------------------------------------------ ----------------------------------RP------------------------ -----------------------------------------WGYMTLRST---------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------STSPCPS DTAVEDT----------------------------------------Q----A------- ------------------------LVVSSGVWGPTLS----------SQELVEFNSNN-S IM-----EEEEE------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVKRREKKASVLFIERDMNPK-GRGITV SLRRLKHFDCKEKQALLDKAREDFDQAIGCCVSLITDYRVRLGCGSFAGSFLEYFAADIS YPVRKSIQQNAEGTRFPQLSRGDP-E--EPEGSSPLEW-RLPC--------RKVLPDRSR AARDRANQRLVEYIVKARGAE--------------------------------------- ------------------------SHLHAILKHGKPSRWLKMFLSSGQYVMCLETYLEDE EQLDRVVKYLQGV-Y-QDVDGDELVQASGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDSVDYKTAEEKYIRGPS------------------------- -------------------LGYR----EKQIFDNQVLEERS---RRH------------- ------------------------------------------------------------ ------------------------------------------------------------ --Q-------------------------------------------- >ENSFDAP00000018917 ------------------------------------------------------MT-DA- KYVLCRWEERLWPAKVLDGPKTSTND--KGEKEFFLDVQILSLDEKIKVKSTEVETLKKS QIENIASLL---ASQREVPTAPLKELTYRRSLRVALDILNERSSLSL-E----------- --------------------------STSRQN---------------------------- -------------------------------------------------------RSAR- ------------CG-RENEPTEAASSL---------------------RNTLCSPVREDV SASSGRS-------------------------------------------A--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------CEKH--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------ELKVD-------------------------------HE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLGRSE------------------------------------------- ---------------------------------------TPGA----------------- ------------------------------------------------------------ ---------------LSAASA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GAGPQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGS----- -------------------------------------GWRSR------------------ -----------------TGHTVTRRRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KSAAQRSSQCQE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------APALLGVQSEEQNTGR A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------SLPQAREDDPCARAEGHDP---------GLPS--------------------- ------------------------------------------------------------ ------------------GSLT-V-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------ER----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AEGHLA-KRLCL----KPPATQLE LELS-------------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------PRL-------- ------------------------------------------------------------ ----------------------------------RP------------------------ -----------------------------------------QGYMILRSA---------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------ASSPCPS DTLVEDSQPPRLLDSG-GN-------------------SLE--E-DPQ----A------- -----------------------------------------------SQERTEFNSHN-S TL-------DEE------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRILFYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVKRREKKASVLFIEKDMNPK-GRGITV SLRRLKHFDCKEKQALLDKAKEDFDQAIGCCISLITDYRVRLGCGSFAGSFLEYFAADIS YPVRKSIQQDAEGTRFPQLSSGDP-E--EPEGSSPLGW-RRPC--------RKVLPDRSR AARDRANQKLVEYIVKARGTE--------------------------------------- ------------------------SHLHAILKSGKPSRWLKMFLSSGQYVTCMETYLEDE EQLDHVVKYLQGV-Y-QDMDGEKLVRASGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYLKGPS------------------------- -------------------LGYR----EKQIFDNQVLEERS---RRH------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSHGLP00100001773 ------------------------------------------------------MT-DA- KYVLCRWEERLWPAKVLDGPKTS-ND--EGEKEFFLDVQILSLDEKIKVKSTEVETLKKS QIENIASLL---ASQTEVPTAPLKELTYRRSLRVALDILNERSSSSLEE----------- --------------------------STSRRN---------------------------- -------------------------------------------------------RSAQ- ------------CR-RENEPTEAASSL---------------------RNSLCSSFREDV SASSGSS-------------------------------------------A--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------CEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------EFKVD-------------------------------HE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------EGLGKSK------------------------------------------- ---------------------------------------SPGA----------------- ------------------------------------------------------------ ---------------LSAAPA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GAGPQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGS----- -------------------------------------GWRSH------------------ ----------------GTGHSLAKRKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNVAQRSSQCQE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------APALLGAQSEEQSTGQ A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------SPPQAREDDPCARAEGHDP---------GLPS--------------------- ------------------------------------------------------------ ------------------GSLT-V-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------ER----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------ARGHPV-KRLCL----RPPSTQLE LELS-------------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------PSL-------- ------------------------------------------------------------ ----------------------------------RP------------------------ -----------------------------------------GGYMTLRSA---------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------AASPCPS DTRVEDSQPPRLQDSG-DD-------------------RLE--E-DPQ----A------- -----------------------------------------------SQECTEFNSNN-S IL-------DEE------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRILFYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVKRREKKASVLFIERDMNPK-GRGITV SLRRLKHFDCKEKQALLDKAKEDFDQAIGCCISLITDYRVRLGCGSFTGSFLEYFAADIS YPVRKSIQQDAEGTRFPQLSRADP-E--EPEGNSPLGW-RRPC--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------SHLHAILKSGKPSRWLKMFLSSGQYVTCMETYLEDE EQLDRVVKYLQGV-Y-QDMDGDKLARASGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYLKGPS------------------------- -------------------LGY-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --RSFNPAELIELEGPLGMVAHTCDPAFWEAEPGRYQIQAQPGQLTT >ENSHGLP00000010078 ------------------------------------------------------MT-DA- KYVLCRWEERLWPAKVLDGPKTS-ND--EGEKEFFLDVQILSLDEKIKVKSTEVETLKKS QIENIASLL---ASQTEVPTAPLKELTYRRSLRVALDILNERSSSSLEE----------- --------------------------STSRRN---------------------------- -------------------------------------------------------RSAQ- ------------CR-RENEPTEAASSL---------------------RNSLCSSFREDV SASSGSS-------------------------------------------A--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------CEKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------EFKVD-------------------------------HE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------EGLGKSK------------------------------------------- ---------------------------------------SPGA----------------- ------------------------------------------------------------ ---------------LSAAPA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GAGPQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGS----- -------------------------------------GWRSH------------------ ----------------GTGHSLAKRKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNVAQRSSQCQE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------APALLGAQSEEQSTGQ A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------SPPQAREDDPCARAEGHDP---------GLPS--------------------- ------------------------------------------------------------ ------------------GSLT-V-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------ER----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------ARGHPV-KRLCL----RPPSTQLE LELS-------------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------PSL-------- ------------------------------------------------------------ ----------------------------------RP------------------------ -----------------------------------------GGYMTLRSA---------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------AASPCPS DTRVEDSQPPRLQDSG-DD-------------------RLE--E-DPQ----A------- -----------------------------------------------SQECTEFNSNN-S IL-------DEE------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------PPRILFYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVKRREKKASVLFIERDMNPK-GRGITV SLRRLKHFDCKEKQALLDKAKEDFDQAIGCCISLITDYRVRLGCGSFTGSFLEYFAADIS YPVRKSIQQDAEGTRFPQLSRADP-E--EPEGNSPLGW-RRPC--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------SHLHAILKSGKPSRWLKMFLSSGQYVTCMETYLEDE EQLDRVVKYLQGV-Y-QDMDGDKLARASGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYLKGPS------------------------- -------------------LGY-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --RSFNPAELIELEGPLGMVAHTCDPAFWEAEPGRYQIQAQPGQLTT >ENSCLAP00000011444 ------------------------------------------------------MT-DA- KYVLCRWEERLWPAKVLDGPKTSTNN--KGEKESFLIVQILSLDEKIKVKSAEVETLKKS QIESIASSL---ASQNEVPTAPLKELTYRRSLRVALDILNEGSSLNQ-E----------- --------------------------STSRRN---------------------------- -------------------------------------------------------GSAW- ------------CQ-REKEPTEAASSL---------------------RDALCSFFREDV SASSG------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EKV--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- --------EFKVD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGPGNSE------------------------------------------- ---------------------------------------TPGA----------------- ------------------------------------------------------------ ---------------RSVAPS--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GAGPQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DAS----- -------------------------------------EWGHR------------------ -----------------TGHAPTRRRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNLAQRSSRCQE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------APALSGAQSEEQSTGR A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------SLPRAREEDPCARAEGHDP---------GLPS--------------------- ------------------------------------------------------------ ------------------GSLTVV-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------ER----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGGPPA-KRLCL----RPPATQLE PVLS-------------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------PRL-------- ------------------------------------------------------------ ----------------------------------RP------------------------ -----------------------------------------QGYMTLRSA---------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DTSPCPS DTPVEDTRPPFLQDSD-SD-------------------RLE--E-DAQ----A------- -----------------------------------------------FQEHMEFNSNN-S IV-------DEE------------------------------------------------ DDDEE------------------------------------------------------- ---------------------------------------------PPRILFYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVKRREKKASVLFIERDMNPK-GRGITV SLKRLKHFDCKEKQALLDKAREDFDQAIGCCVSLITDYRVRLGCGSFAGSFLEYFAADIS YPVRKSIQQDAEGTRFPQLSGGDP-K--EPEGDSPLGW-SLPC--------RKVLPDRSR AARDRANQKLVEYIVKARGAE--------------------------------------- ------------------------SHLHAILKNGKPSRWLKMFLGSGQYATCMETYLEDE EQLDRVVKYLQGV-Y-QDMDGDRLARASGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYLKGPS------------------------- -------------------LGYR----EKQIFDNQVLEERS---RRH------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSCAPP00000003349 ------------------------------------------------------MT-DA- KYVLCRWEERSWPAKVLDGPKTSTND--KGEKETFLDVQILSLDEKLSVKSTEVETLKKS QIEKIASCL---ASQHEVPAAPLEELTYRRSLRVALDVLNEDSS---------------- ------------------------------------------------------------ ----------------------------------------------------------WS RQSPARRSGSNECR-REKQPTEAASSL---------------------RN---------- ------SPSFFREDA---------------------------SAGSRPSTA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EKD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------EFKVD-------------------------------PK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLGKSE------------------------------------------- ---------------------------------------APGT----------------- ------------------------------------------------------------ ---------------LSAAPA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GASPR----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGS----- -------------------------------------EWGHR------------------ -----------------TGHTLAKRRG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KNLAQRSGRCQEE-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------ASALCGPPSEEPGTGQ T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------SPPRAREDDPCARAEGHDP---------GLPS--------------------- ------------------------------------------------------------ ------------------GSLTVV-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- -----------------------------------ER----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AAEPPA-KR--------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------PRL-------- ------------------------------------------------------------ ----------------------------------RPPVTPLER----------------- -----------------------ELSLGT---------ATG------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------PCSP DTAVEDTQPPCLQDGGSSD-------------------RLE--E-DLQ----A------- -----------------------------------------------SQEQPEFNSSN-P TV--------EE------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVKRREKKASVLFIERDMNPK-GRGITV SLRRLKHFDCKEKQALLDKAREDFDQAIGCCVSLITDYRVRLGCGSFAGSFLEYFAADIS YPVRKSIQQDAKGTRFPQLSRGDP-E--EPEGNSPLGW-QRPC--------KKVLPDRSR AARDRANQKLVEYIVKTRGAE--------------------------------------- ------------------------SHLHAILKNGKPSRWLKMFLSSGQYVTCMETYLEDE EQLERVVKYLQGV-Y-QDMDGDKLARARGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYIKGPS------------------------- -------------------LGYR----EKQIFDNQVLEERS---RRH------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSLAFP00000011261 ------------------------------------------------------MM-DA- KYVLCRWKKRLWPAKVLARTERSTKN--KRKKEFFLDVQILSLDEKMKVKSTGVEILKKS RIEDIASLL---ASQNEALATPLQELTYRRSLRVALDVLNEGASSSQ-E----------- --------------------------SPSREE---------------------------- -------------------------------------------------------REAL- ------------SP-SRK-PTDSASSLCGSDSA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------TFHHGDTSGSPRAGRRGRAQHSRLSSPTPGKDLKCPVES EQGPGCGRNPEAPPAPPAAP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GCR----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGSRSQTH RKAW-------------------------------------------------------- --------------------TCPRKRE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RNSAQTSSLHQDVPS------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SVS---GR--------------EEEK------ESEEKAGSPPDLA----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------SPSNVREDEECARADG------------------------------------- ------------------------------------------------------------ ------------------GSL-------------------------VSPAG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------------------------------ ---------------------------------L-------------------------- -------------------------------------------PAL-------------- -----------------------------PASRKMAE----------------------- ---------------------------------------LPA-KRRRLGGRQRP------ ---------------------------------------------------------CVG E----------------------------------------------PGMGPAGPVLH-- -------------------------------------------------PRQ-------- ------------------------------------------------------------ ----------------------------------GP----VEQAPATHTLS-------PH FPDP--E-----EA--------EE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------E-GRQ----A------- -----------------------------------------------SEGSVELGSLH-S IL-------DED------------------------------------------------ -EDEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSLRRRDKKASVLFIEGNMNPK-GRGITV SLRRLKHFDCKEKQTLLDKAKQDFEQDVGWCVSLITDYRVRLGCGSFSGSFLEYYAAAIS YPVRKSIQQDVLGARFPQLSGGDP-E--EPEAESPLGR-SHRC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILKSRKPSRWLKTFLNSGQYVTCVETYLEDE EQLDLVVKYLQGV-Y-QETGSTVLTRVNGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVDAVDYKTAEEKYIKGPS------------------------- -------------------LSYR----EKEIFDNQVLEERS---RRH------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSMUSP00000020365 ------------------------------------------------------MT-DA- KYVLCRWGKRLWPAKVLARTETSAKN--KKKKEFFLDVQILSLKEKIQVKSSAVEALQKS HIENIAAFL---ASQNEVPATPLEELTYRRSLRVALDVLNERTSLS-------------- ------------------------------------------------------------ -----------PESHPIED------------------------------------GITL- ------------SQ-KEK------------------------------------------ --------------TDADVASQVSS----------------------------------- ------------------------------------APSPSLLGEDGQAVVAQCASKRRS EYSSKSLLP-SSALEDHLRCQVGPKTGLSESGA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GDKSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DDSGLQ-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HGQESTTKKRQRNLGEKPTRRRR SESGLSKGESVLKSQGQASSCVAL------------------------------------ ------------------------------------------------------------ ---ASPRPPSQTRDEEPCAGVKGCD----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------WVKSSG---------NIR------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------------------------------ ---------------------------------L-SASER-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------SRGCPT-KRPRLDGGQNPPTRQL- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GTRTVGAAPC----------PRS-------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CSGEVTMLCSA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GAGD-------------------KPE--E-DPV----S------- -----------------------------------------------SEESTGFKSTH-S LL------EEEE------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPK-GRGITV SLRRLKHFDCKEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-E--EPVGDSQLGQ-WRPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILHSRKPSRWLKTFLSSSQCVTCMETYLEDE AQLDEVVEYLQGV-C-RDMDGQVPERGSGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVEAVDYKTAEQKYIRGPT------------------------- -------------------LSYR----EKEIFDNELLEERN---RRR------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >MGP_SPRETEiJ_P0025035 ------------------------------------------------------MT-DA- KYVLCRWGKRLWPAKVLARTETSAKN--KKKKEFFLDVQILSLKEKIQVKSSAVEALQKS HIENIAAFL---ASQNEVPATPLEELTYRRSLRVALDVLNERTSLS-------------- ------------------------------------------------------------ -----------PESHPIED------------------------------------GTTL- ------------SQ-KEK------------------------------------------ --------------TDADVASQVSS----------------------------------- ------------------------------------APSPSLLGEDGQAVVAQCASKRRS EYSSKSLLP-SSALEDHLRCQVGPKTGLSESGA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GDKSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DDSGLQ-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HGQESTTKKRQRNLGEKPTRRRR SEAGLSKGESVLKSQGQASSCVAL------------------------------------ ------------------------------------------------------------ ---ASPRLPSQTRDEEPCAGVKGCD----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------WVKSSG---------NIR------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------------------------------ ---------------------------------L-SASER-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------SRGCPT-KRPRLDGGQNPPTSQL- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GTRTVGAAPC----------PRS-------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CSGEVTMLCSA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GEGD-------------------KPE--E-DPV----S------- -----------------------------------------------SEESTGFKSTH-S LL------EEEE------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPK-GRGITV SLRRLKHFDCKEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-E--EPVGDSQLGQ-WRPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILHSRKPSRWLKTFLSSSQCVTCMETYLEDE AQLDEVVEYLQGV-C-RDMDGQVPERGSGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVEAVDYKTAEQKYIRGPT------------------------- -------------------LSYR----EKEIFDNELLEERN---RRR------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSMSIP00000007736 ------------------------------------------------------MT-DA- KYVLCRWGKRLWPAKVLARTETSAKN--KKKKEFFLDVQILSLKEKIQVKSSAVEALQKS HIENIAAFL---ASQNEVPATPLEELTYRRSLRVALDVLNERTSLS-------------- ------------------------------------------------------------ -----------PESHPIED------------------------------------GTTL- ------------SQ-KEK------------------------------------------ --------------TDADVASQVSS----------------------------------- ------------------------------------APSPSLLGEDGQAVVAQCASKRRS EYSSKSLLP-SSALEDHLRCQVGPKTGLSESGA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GDKSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DDSGLQ-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HGQESTTKKRQRNLGEKPTRRRR SESGLSKGESVLKSQGQASSCEAL------------------------------------ ------------------------------------------------------------ ---ASPRLPSQTRDEEPCAGVKGCD----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------WVKSSG---------NIR------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------------------------------ ---------------------------------L-SASER-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------SRGCPT-KRPRLDGGQNPPTRQL- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GTRTVGAAPC----------PRS-------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CSGEVTMLCSA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GEGD-------------------KPE--E-DPV----S------- -----------------------------------------------SEESTGFKSTH-S LL------EEEE------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAVPEAERH RQGRGLLLRDQDGSLAWWHTPVILSHMEFKVKSVRRRDKKASVLFIEGNMNPK-GRGITV SLRRLKHFDCKEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-E--EPVGDSQLGQ-WRPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILHSRKPSRWLKTFLSSSQCVTCMETYLEDE AQLDEVVEYLQGV-C-RDMDGQVPERGSGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVEAVDYKTAEQKYIRGPT------------------------- -------------------LSYR----EKEIFDNELLEERN---RRR------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >MGP_CAROLIEiJ_P0023880 ------------------------------------------------------MT-DA- KYVLCRWGKRLWPAKVLARTETSAKN--KRKKEFFLDVQILSLKEKIQVKSSAVEALQKS HIENIAAFL---ASQNEVPATPLEELTYRRSLRVALDVLNERTSLS-------------- ------------------------------------------------------------ -----------PESHPIED------------------------------------GTTL- ------------SQ-KEE------------------------------------------ --------------TDADVASQVSS----------------------------------- ------------------------------------APSPSLLGEDGQAVVTQCASKRRS ECSPKSLLP-SSAFEDHLRCQVCPKTGLSESGV--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GDGSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GDSGLQ-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HGQESTTKKRQRNLGEKPTRRRR SEAGLSKGESVLKSQGQATSCVAL------------------------------------ ------------------------------------------------------------ ---ASPRLPSQTRDEESCAGVKGCD----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------WVKSSG---------NIR------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------------------------------ ---------------------------------L-TASER-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------SRGCPT-KRPRFDGGQNPPTRQQ- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GTRTVGAAPC----------PRS-------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CSGEATMLCSA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GERD-------------------KPE--E-DPV----S------- -----------------------------------------------SEESTGFKSTH-S LL------EEEE------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPK-GRGITV SLRRLKHFDCKEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-E--EPVGDSQLGQ-WRPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILHSRKPSRWLKTFLSSSQCVTCMETYLEDE AQLDEVVEYLQGV-C-RDMDGQVPERGSGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVEAVDYKTAEQKYIRGPT------------------------- -------------------LSYR----EKEIFDNELLEERN---RRR------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >MGP_PahariEiJ_P0087034 ------------------------------------------------------MT-DA- KYVLCRWEKRLWPAKVLARTETSAKN--KRKKEFFLDVQILSLKEKIQVKSSAVEALQKS HIENIAAFL---ASQNEVPATPLEELTYRRSLRVALDILNERTSLS-------------- ------------------------------------------------------------ -----------PESHPIED------------------------------------GTTL- ------------SQ-KEK------------------------------------------ --------------TDADVASQVSS----------------------------------- ------------------------------------APSPSFLGEDGQAVVAQCASKRRW ECSPKSLSP-SPAFED-LGCKVGPKTGLSESGAPGAQVPA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GDRSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DDSGLQ-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HGQESTTKKRQRNLGEKPTRRRR SESGLSKGESVLESQGQASSCVAL------------------------------------ ------------------------------------------------------------ ---ASPRLPSQTWDEEPCAGVKGRD----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------WVESSG---------NIG------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------------------------------ ---------------------------------L-SASER-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------SRGCPT-KRPRLDGGQNPPTRQL- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GTRPVGAASC----------PRS-------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CSGEVMMLCSA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GEGD-------------------KPE--E-DPV----S------- -----------------------------------------------SEEPTGFKSTH-S LL-------EEE------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPK-GRGITV SLRRLKHFDCKEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-X--EPVGDSQLGQ-WRPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILHSRKPSRWLKTFLSSSQCVTCMETYLEDE AQLDEVVEYLQGV-C-RDMDGQVPERGSGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVEAVDYKTAEQKYIRGPT------------------------- -------------------LSYR----EKEIFDNELLEERN---RRR------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSRNOP00000057438 ------------------------------------------------------MT-DA- KYVLCRWEKRLWPAKVLARTETSAKN--KRKKEFFLDVQILSLKEKIQVKSSAVEALQKS HIENIAAFL---ASQNEVPATPLEELTYRRSLRVALDVLNERTSLS-------------- ------------------------------------------------------------ -----------PESHPVEN------------------------------------GSTP- ------------SQ-KGK------------------------------------------ --------------PDADMASQVSS----------------------------------- ------------------------------------APSPSFLSEDDQAVAAQCASKRRW ECSPKSLSPLSASEED-LRCKVDPKTGLSESGALGTEVPA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GDESQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------NGSGSQ-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------HGQESTTKKRQRNSGEKPARRGK AESGLSKGDSVAESGGQASSCVAL------------------------------------ ------------------------------------------------------------ ---ASPRLPSQTWEGDPCAGVEGCD----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------PVESSG---------NIR------ ------------------------------------------------------------ ------------------------------------------------------P----- ------------------------------------------------------------ ---------------------------------L-LDSER-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------SKGRLT-KRPRLDGGRNPLPRHL- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GTRTVGAVPS----------RRS-------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------CSGEVTTLRRA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GDSD-------------------RPE--EADPM----S------- -----------------------------------------------SEESTGFKSVH-S LLEEEEEEEEEE------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPK-GRGITV SLRRLKHFDCKEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-E--EPMGDSRLGQ-WRPC--------RKVLPDRSR AARDKANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILHSRKPSRWLKTFLSSNQYVTCMETYLEDE AQLDEVVEYLQGV-C-RDMDGEMPARGSGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVEAVDYKTAEQKYLRGPT------------------------- -------------------LSYR----EKEIFDNELLEERN---RRR------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSMUGP00000024715 ------------------------------------------------------MT-DA- KYVLCRWEKRLWPAKVLARTETSAKN--KRKKELFLDVQILSLKEKIQVKSSAVEALQKS HIENIAAFL---ASQNEVPATPLEELTYRRSLRVALDVLNERGSLS-------------- ------------------------------------------------------------ -----------PESRLMED------------------------------------GTTL- ------------SQ-KEK------------------------------------------ -------------------------AL--------------------------------- -------------------------ADSASPVSASRAPSPSVLGEDGQDVVAQCAPKRRW GCM--------------------------------------------------------- --------------PQSLSGLSAFEEK--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------GCKAD-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------TALSKSG------------------------------------------- ---------------------------------------TPRT----------------- ------------------------------------------------------------ ---------------PAPSRT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------ADGSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DGSGSR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RGQEGTTNKRRRNLGEKPTRHRR TGSSLSKGEGVAESEGQA-SCVSP------------------------------------ ------------------------------------------------------------ ---ASPRLPPQTQEEGPCASVKGCDR---------VMSS--------------------- ------------------------------------------------------------ ------------------GSG-LP-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SDR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GRERSA-KRPRLDSGQNPPTRQL- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GTRTVGAAPS----------PGS-------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------RSGEVTMLRSA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GDSD-------------------KAE--E-DPV----S------- -----------------------------------------------SEESTGLKSVQ-S LL------EEEE------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPK-GRGITV SLRRLKHFDCKEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-E--APAGDSQPGQ-WRPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILHSRKPSRWLKMFLSSGQYVTCVETYLEDE AQLDEVVGYLQGI-C-RDMDGEVPASGSGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAIAAVESVDYKTAEQKYIRGPT------------------------- -------------------LSYR----EKEIFDNELLEERS---RRR------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSCGRP00015006556 ------------------------------------------------------MT-DA- KYVLCRWEKRLWPAKVLAITETSVKN--RRKKELFLDVQILSLKEKIQVKSSAVEALQKS HIENIAAFL---ASQNEVPAAPLEELTYRRSLRVALDLLNERTNLS-------------- ------------------------------------------------------------ -----------PESHLMKD------------------------------------ETTL- ------------SQ-KEK------------------------------------------ --------------PHADMASWIPS----------------------------------- ------------------------------------AP---------------------- -------------------------------------------------SLSFHGEDGED VAAQRISKSRWEYVPQSLSGLSASEED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------RCKVD-------------------------------RK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------TGLSKNG------------------------------------------- ---------------------------------------TPRA----------------- ------------------------------------------------------------ ---------------ALLSPT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GDGSR----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DSSGSR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RGQEDTTSKRRRDLGEKPTRRHK TESRLSKGESVVENEGQASSCVTP------------------------------------ ------------------------------------------------------------ ---ASPRLLSQTWEEDPCAGVKGFDR---------VVPS--------------------- ------------------------------------------------------------ ------------------GSSRLL-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SER-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GRRHPT-KRPRLDGGQNPQARQL- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GTGTVGAVPS----------LRS-------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------WSGEAMVLRSA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GDND-------------------KPE--E-DPV----S------- -----------------------------------------------SEESTGFKSIH-S LL------EDEE------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPK-GRGITV SLRRLKHFDCKEKHTLLERAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS HPVRKSIQQDVLGTRFPQLGKGD-AE--EPVGDSRPGQ-WRPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILHSRKPSRWLKTFLSSGQYVTCVETYLEDE AQLDEVVEYLQGI-C-RDMDGEVPARGSGDRIRFVLDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVESVDYKTAEQKYIRGPT------------------------- -------------------LSYR----EKEIFDNELLEERN---RRR------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSCGRP00001014056 ------------------------------------------------------MT-DA- KYVLCRWEKRLWPAKVLAITETSVKN--RRKKELFLDVQILSLKEKIQVKSSAVEALQKS HIENIAAFL---ASQNEVPAAPLEELTYRRSLRVALDLLNERTNLS-------------- ------------------------------------------------------------ -----------PESHLMKD------------------------------------ETTL- ------------SQ-KEK------------------------------------------ --------------PHADMASWIPS----------------------------------- ------------------------------------AP---------------------- -------------------------------------------------SLSFHGEDGED VAAQRISKSRWEYVPQSLSGLSASEED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------RCKVD-------------------------------RK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------TGLSKNG------------------------------------------- ---------------------------------------TPRA----------------- ------------------------------------------------------------ ---------------ALLSPT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GDGSR----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DSSGSR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RGQEDTTSKRRRDLGEKPTRRHK TESRLSKGESVVENEGQASSCVTP------------------------------------ ------------------------------------------------------------ ---ASPRLLSQTWEEDPCAGVKGFDR---------VVPS--------------------- ------------------------------------------------------------ ------------------GSSRLL-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SER-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GRRHPT-KRPRLDGGQNPQARQL- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GTGTVGAVPS----------LRS-------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------WSGEAMVLRSA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GDND-------------------KPE--E-DPV----S------- -----------------------------------------------SEESTGFKSIH-S LL------EDEE------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPK-GRGITV SLRRLKHFDCKEKHTLLERAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS HPVRKSIQQDVLGTRFPQLGKGD-AE--EPVGDSRPGQ-WRPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILHSRKPSRWLKTFLSSGQYVTCVETYLEDE AQLDEVVEYLQGI-C-RDMDGEVPARGSGDRIRFVLDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVESVDYKTAEQKYIRGPT------------------------- -------------------LSYR----EKEIFDNELLEERN---RRR------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSCGRP00000018891 ------------------------------------------------------MT-DA- KYVLCRWEKRLWPAKVLAITETSVKN--RRKKELFLDVQILSLKEKIQVKSSAVEALQKS HIENIAAFL---ASQNEVPAAPLEELTYRRSLRVALDLLNERTNLS-------------- ------------------------------------------------------------ -----------PESHLMKD------------------------------------ETTL- ------------SQ-KEK------------------------------------------ --------------PHADMASWIPS----------------------------------- ------------------------------------AP---------------------- -------------------------------------------------SLSFHGEDGED VAAQRISKSRWEYVPQSLSGLSASEED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- --------RCKVD-------------------------------RK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------TGLSKNG------------------------------------------- ---------------------------------------TPRA----------------- ------------------------------------------------------------ ---------------ALLSPT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GDGSR----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DSSGSR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RGQEDTTSKRRRDLGEKPTRRHK TESRLSKGESVVENEGQASSCVTP------------------------------------ ------------------------------------------------------------ ---ASPRLLSQTWEEDPCAGVKGFDR---------VVPS--------------------- ------------------------------------------------------------ ------------------GSSRLL-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SER-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GRRHPT-KRPRLDGGQNPQARQL- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GTGTVGAVPS----------LRS-------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------WSGEAMVLRSA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GDND-------------------KPE--E-DPV----S------- -----------------------------------------------SEESTGFKSIH-S LL------EDEE------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPK-GRGITV SLRRLKHFDCKEKHTLLERAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS HPVRKSIQQDVLGTRFPQLGKGD-AE--EPVGDSRPGQ-WRPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILHSRKPSRWLKTFLSSGQYVTCVETYLEDE AQLDEVVEYLQGI-C-RDMDGEVPARGSGDRIRFVLDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVESVDYKTAEQKYIRGPT------------------------- -------------------LSYR----EKEIFDNELLEERN---RRR------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSMAUP00000016093 ------------------------------------------------------MT-DA- QYVLCRWEKRLWPAKVLAITETSVKN--RRKKELFLDVQILSLKEKIQVKSSAVEALQKS HIENIAAFL---ASQNEVPAAPLEELAYRRSLRVALDLLNERTSLG-------------- ------------------------------------------------------------ -----------PESHPIED------------------------------------ETTL- ------------SQ-KEK------------------------------------------ --------------PHTDMASWVPS----------------------------------- ------------------------------------APPPSSLGEDGEDAAAQRTPRRRW ECVPQSLS-------------------------------AWSSSGEDRE----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------TPRA----------------- ------------------------------------------------------------ ---------------ALPSPT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------EDGSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DSSGSR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RGQEDKTNKRRRNLGEKPTQHHK AESRLSKGESVVDSEGQGSSYTTP------------------------------------ ------------------------------------------------------------ ---ASPRLLSQTRDEDPCAGVKGCDR---------VVPS--------------------- ------------------------------------------------------------ ------------------GSSRLL-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SQR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GKGHPT-KRPRLDGGQNPPASQL- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GPGTVGAVPS----------PRS-------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------WSGEAMVPHS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------DTD-------------------KPE--E-DPV----S------- -----------------------------------------------SEESTGFKSVQ-S LP------EEEE------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGTMNPK-GRGITV SLRRLKHFDCKEKHTLLERAKEDFSQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDPEE--EPVGDSQPGQ-WRPC--------RKVLPDRSR AARDKANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILHSRKPSRWLKTFLSSGQYVTCVETYLEDE AQLDEVVGYLQGV-C-RDMDGEVPARGSGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVESVDYKTAEQKYIRGPT------------------------- -------------------LSYR----EKEIFDNELLEERS---RRR------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSPEMP00000027994 ------------------------------------------------------MT-DA- KYVLCQWEKRLWPAKVLARTETSAKN--KRKKELFLEVQILSLKEKIQVKSSAVEKLQKS HIENIAAFL---ASQNDVPATPLEELAYRRSLRVALDILNERTSLS-------------- ------------------------------------------------------------ -----------PEGHVTED------------------------------------ETSP- ------------SR-NEK------------------------------------------ --------------ADAEAASWVPS----------------------------------- ------------------------------------AP---------------------- -------------------------------------------------SPSFCGEDGED VAARRTPKGRWECAPQSLAGSCAAEED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------PK------ -ADLPENAA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GDGSQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DSSGSR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RGQEDTSNKRQRNLGEKPTRRRR TESRL------------------PKGES---------LSGSEGPA------------GS- -----------------------------------------------------------P AALASPRPLSQTWGEDPCAGVKGCDQ---------LVPS--------------------- ------------------------------------------------------------ ------------------GSSKLL-PA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SER-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GRGRTT-KRPRLDGGQNPPARQL- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GTGTGGAAPS----------PGS-------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------WSGEAMALCSA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GDSE-------------------KPE--E-DLV----S------- -----------------------------------------------SEESTGFKSIH-P LL------EEEE------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------PPRILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDRKASVLFIEGNMNPK-GRGITV SLRRLKHFDCKEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-E--EPVGDSRPGQ-WRPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAVLCSRKPSRWLKTFLTSGQYVTCVETYLEDE AQLDEVVEYLQDI-C-RDMDGEVPARGGGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAISAVESVDYKTAEQKYIRGPT------------------------- -------------------LSYR----EKEIFDNELLEERN---RRR------------- ------------------------------------------------------------ --------------------------------------RC-------------------- --R-------------------------------------------- >ENSNGAP00000023751 ------------------------------------------------------MS-DA- QYVLCKWEKRLWPAKVLSRTEMATKN--KTKKEFFLEVQILSLKEKIQVKSSAVEVLQKS HIENIATFL---ASQNEVPAAPLEELTYRRSLRVALDILNQTTSLSQ-E----------- --------------------------SQS----------------LNQDGAV-------- ---------LSP------------------------------------------------ ---------------KEK------------------------------------------ --------------LCTDVASWVPSSLFPSFLPEGDKDGKVQS----------------- ----------------GPKKRQECKA---------------------------------- ------------------------------------------------------------ ---------------QSLPGLSAHKED--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------S------- --------ECRVA-------------------------------HK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------TGLGKSGT------------------------------------------ ----------------------GNGSRDGPASQQGHRHET-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------TANKRWRNSGEKPT---- ----------------------------------------------------------WP RRRGSNLSQGERIGEIQRRADSCMTPTSTRLPSGIQEEDLHVNVKGSDPSMPLGMGLKLP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PER-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GRGRPP-KRPRPDAGQNPPTMQLR ------------------------------------------------------------ ------------------------------------------------------------ ------TETRRAAAAPRKETKEAPTVRSIG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------DVD-------------------RPE--EEDPP----S------- -----------------------------------------------PEKSEEFSSIR-S LL-----EDEDE------------------------------------------------ DEDEE------------------------------------------------------- ---------------------------------------------PPQILLYRE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEVGMLVWLKYQKYPFWPAV------ ------------------------------VKSVRRRDKKASVLFIEGNMNPK-GRGITV SLRRLKHFDCSEKHMLLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDLLGTRFPQLGKGNP-E--KPLGDSPLGQ-WRPC--------RKVLPDRSR AARDRANQKLVEYIVKAKGAE--------------------------------------- ------------------------SHLRAILHSRKPSRWLKTFLSSGQYVTCVETYLEDE GQLDEVVEYLQGV-C-RDMDGEVPAQGSGDRIRFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAIAAVDAVDYKTAEQKYIQGPT------------------------- -------------------LSYR----EKEIFDNELLEERS---RRR------------- ------------------------------------------------------------ ------------------------------------------------------------ --R-------------------------------------------- >ENSSHAP00000016424 ------------------------------------------------------MM-DT- QYVLCRWKKRLWPAKVLPQTGLSTRKHIQKMRSAFLNVEILSLDKKIKVKKTETKILEKS QIEEIAAEL---TTQVEIKTTPKEELIYRRSLKFGLDVLSQKADAIE------------- ---------------------------------------------------ANSLSKSLT TPVLHKLKQTRPA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------HAVSESDSSPFVCEEVVG GSGPFKKENVLQR----------------------------------------------- ------------------------------------------------------------ -----------------LSSSPIEENK--------------------------------- ------------------------------------------------------------ --C--------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------K-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLKRSVRIYGNKTEPLASPARNIFGTQKLQHQKSEIPKSWSRTGKNQKQ KKDDSSQNLQLNLKKKLEIKDSG------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------KKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RK------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --RPRISNRYS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SPFNAREED-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------D TNTELGELSPVLSSSNSIHLMA--------LEKKTSSSSRKALDFSTNRSFVESECENEL GKV---------------------------------------------------P----- -----------------------------------SLKYC-------------------- -------------------------------KVL-------------------------- -------NGIKQ----------SSVSECHC-----------LEP---------------- ------------------------------------EEIG-------------------- -------------LCTNGSDTPPG------------------------------------ ------------------------------------------------------VSNC-- -----------------------------------------------------------S LVC----------------------------------------------PNY-------- ------------------------------------------------------------ ---------------------------------FAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------KTRTLK------------------------------ --------------------------------------------LPDFE----------- --------------------------------------DDE--E-ELQ----S------- -----------------------------------------------SEQSLEFSSVNTT VV-------DEE------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPSILSRPE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCSIEAGMLVWCKYQKYPYWPSV------ ------------------------------VKSVKRKDKKASILYIEGNMNPE-KRGFTV SLRRLKHFDCEEKQELMDKAKEDYSQGVDWCIMLISDYRIRIGCGSFVGSFLEYYSADIS CPVRKVIQQAPIKTVFPILNKEEP-E--DGLSDTSLNK-KQSF--------KKVLPDRRR AARDKANEKLVEYIVNEKGAE--------------------------------------- ------------------------NHLLAILKSRKKSRWLKEFLNSSQYMTCVETYLEDD EQLYLVVKYLQEV-Y-QEIDSKMLTLINGDGIKFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYAISAIDEIDYQTAEKKYIEGPS------------------------- -------------------VSKR----EREMFDKELLEEKK---KEL------------- ------------------------------------------------------------ -----------------TLL---KTETSFPEMS--------------------------P DVSK------------------------------------------L >ENSPCIP00000014324 -------------------------------------------------------M-DT- QYVLCRWRERLWPAKVLSQTGISRRQHIRKRKAAFLEVEILSLDEKIKVKKTETRILEKS QIEDIAAEF---STQVKIKTTPIEELIYRRSLKVALDILSQKADASQ------------- ---------------------------------------------------VNCLDESLT TPILRKVKQTRPA----------------------------------------------- ------------------------------------------------------------ ------------------------------------------HAVSESDSSPFVCEEIVG GSGPFKKENVLQR----------------------------------------------- ------------------------------------------------------------ -----------------LSSSPIEENK--------------------------------- ------------------------------------------------------------ --F--------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------K-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLKKSNRIYSNETEPLASQTRNIFGTRKQQHQNCEISKSRSRTWKNQKQ KKNDSSQNSQRNLKKKLEVKDNR------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------KKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RN------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KPRTSHRNS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SPFKARGCN-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G TDTELGELSPVLSSS-SIQLVT--------LEEKASSAVQKALDFSTSLSFVKSECANEH GRM---------------------------------------------------P----- -----------------------------------SQKCC-------------------- -------------------------------KVL-------------------------- -------GGIKQ----------SSVSECCC-----------VEP---------------- ------------------------------------EGTG-------------------- -------------LCTSGSD---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------PSC-------- ------------------------------------------------------------ ---------------------------------FAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------KSRALK------------------------------ --------------------------------------------LPDFE----------- --------------------------------------EDE--E-ELQ----A------- -----------------------------------------------SEWSLEFSTVNTT MV-------DEE------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPSILSHPE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCSIEAGMLVWCKYQKYPYWPAV------ ------------------------------VKSIKRKDKKASILYIEENMNPE-KKGFIV CLRRLKYFDCEEKRELVDKAKEDYSQAVDWCIKLISDYRIRIGCGSFAGSFLEYYSADIS VPVRKGMRQAPIKTVFPILNKEDP-E--DGLPDTSLNK-KLLF--------KKVLPDRRR AARDKANEKLVEYIVNEKGAE--------------------------------------- ------------------------NHLLAILKSRKKSRWLKEFLDSSQYMKCVETYLEDD EQLDLVVKYLQGI-Y-QEIDSKMLKLINGDGIKFILNVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------VIYAISATDEIDYQTAEEKYIKGPS------------------------- -------------------VSKR----EREMFDKELLEKKQ---GT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSMODP00000006402 ------------------------------------------------------MM-DT- EYVLCRWEKRLWPAKVLPQTGISRRHHIQKRKAAFLDVEILSLDKKIKVKKTEIKALEKS HIEEIASEF---ITQVAINTPVTEELIYRRSLKAAMDILDQKADASQ------------- ---------------------------------------------------INSLGKRLT TPQLHKVKQMRPE----------------------------------------------- ------------------------------------------------------------ ------------------------------------------NAVSES----FVCEEVIG GSGPFKKENVPQR----------------------------------------------- ------------------------------------------------------------ -----------------LSSSPTEENK--------------------------------- ------------------------------------------------------------ --C--------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------K-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------KGLKRSNRIHGNKTEPLASPIRNIFDTQKPQPKNCEILKSQSKTWNNRKQ KKDDSSQNSQLNLTKKLKVKETG------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------RK------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --RPRTSNSNSS----------------------LC------------------------ ----------------------------------------------KAKKD--------- -------------GD--------------------------------------------- ------RSP--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EIGEISPVLSTSSSILLIA--------LEEKARNPVQKALDFSSNCSFVESECENEH GKM---------------------------------------------------P----- -----------------------------------SQKYC-------------------- -------------------------------KVL-------------------------- -------GGIKQ----------SAVSECRC-----------VEP---------------- ------------------------------------EGTG-------------------- -------------LCNSGSHTPLG------------------------------------ ------------------------------------------------------VSNC-- -----------------------------------------------------------S LDY----------------------------------------------PGY-------- ------------------------------------------------------------ ---------------------------------VAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------KTRILK------------------------------ --------------------------------------------LPDFK----------- --------------------------------------EDE--E-ELQ----S------- -----------------------------------------------SEESLEFSTINTA VV-------DEE------------------------------------------------ DEDEE------------------------------------------------------- ---------------------------------------------LPSILLYHE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCSIEAGMLVWCKYQKYPYWPAV------ ------------------------------VKSVMRKDKKASILYIEENMNPK-KRGFTV GLRRLKHFDCEEKQELMDKAKEDYSQAVDWCITLISDYRVRIGCGSFTGSFLEYYSADIS CPVRKVIQQESNKTMFPIPNKEDS-E--DGLPETPTNK-KQPF--------KKVLPDRMR AARDKANEKLVEYIVNEKGAE--------------------------------------- ------------------------NHLLAILKSRKESKWLKEFLNSSQYVTCVETYLEDD EQLDLVVKYLQGV-Y-QEIDSKMLTLINGDRIKFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYAISVIDQIDYQKAEEKYIKGPS------------------------- -------------------LSER----EREIFNKELLEKKK---GTF------------- ------------------------------------------------------------ -----------------T------------------------------------------ DAD-------------------------------------------- >ENSMUSP00000109754 ------------------------------------------------------M--DSS EYVLCGWKSQLCPARVLSRPRTPAHS--KRRGVPFLEVQILPVGEKRRVRSSKVRPLAKS EIISINSLA---GKESRGRGSPGQTRASRRALKVALDGLGEGSSF--------------- ------------------------------------------------------------ ---------------------------------------------FQGGRAGS-RRTSTL ------------A---PKVPKEQASS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SSSSLGQRL RLRLR-------QLLPLSLCQRLHLH---LRLR------LH--LHMH------LCLQGRN QKGQGLSQRSP-------------GKRVRPD----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------PGPVMMGSQNVP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVPVGEAQAHTAAGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PRS-------------- ------------------------------------------------------------ ---------------------------------------EVEGDVLRG------------ ----------TRVWPSYSKKTPLGKAGGNPGKRKPGTGK--------------------- RKLRSLS---------APASRKGTRSKTEQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QAAS----------------------------GPPR--------------------- ------------------------------------------------------------ ------------------HISISP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKQRVRC----------------------- --------AGLEIRAAGAQRKTAL------------------------------A----- --------------------------------------------E-NKDHPGL------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GTPKPDSKRASAACMPPVLRL RRSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIASRKKKTHVLCAL------------------------- ----CGLPEWEPQVHSKVTNTRFKRRGARV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QKDAK------------------------------------------------------- ---------------------------------------------ATNVVSAQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PSTIEQGTLVWFKFQDLPFWPAV------ ------------------------------VKSVSKIDKMARVLLIEGNMQFE-RRGIRV PLRKLKHLDCGEKVSLVRRASRLYAQGINWCFSVIDHYREGLSRGSLLGSFMDYYTTQAS YPLRRAVQEGDLHIDFPKVSYAEL-E--DWEEETALGG-KGPY--------KKLLPDRMR AAWDRANQKLVDFIVKRKGAD--------------------------------------- ------------------------QHLLDIVKGRKPSRWLDDLWKSKREVFCIETYLEDD DQLHLVARHLQEV-A-KEADEALLSLARGDKVRFTMEVLFP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYSIAALDELSYKEAEEKYLRGPP------------------------- -------------------VHYR----EKELFDKTILKAAR---KRS------------- -------------------------------------------AAR-------------- ----------IRA-------------ARDPPVP--------------------------- -TP-------------------------------------------- >ENSMUSP00000109751 ------------------------------------------------------M--DSS EYVLCGWKSQLCPARVLSRPRTPAHS--KRRGVPFLEVQILPVGEKRRVRSSKVRPLAKS EIISINSLA---GKESRGRGSPGQTRASRRALKVALDGLGEGSSF--------------- ------------------------------------------------------------ ---------------------------------------------FQGGRAGS-RRTSTL ------------A---PKVPKEQASS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SSSSLGQRL CLRLR-------QLLPLSLCQRLHLH---LRLR------LH--LHMH------LCLQGRN QKGQGLSQRSP-------------GKRVRPD----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------PGPVMMGSQNVP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVPVGKAQAHTAVGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PRS-------------- ------------------------------------------------------------ ---------------------------------------EMEGDVLRG------------ ----------TRVWPSYSKKTPLGKAGGNPGKRKPGTGK--------------------- RKLRSLS---------APASRKGTRFKTEQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QAAS----------------------------GPPR--------------------- ------------------------------------------------------------ ------------------HISISP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKQRVRC----------------------- --------AGLEIRAAGAQRKTAL------------------------------A----- --------------------------------------------E-NKDHPGL------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GTPKPDSKRASAACMPPVLRL RRSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIASRKKKTHVLCAL------------------------- ----CGLPEWEPQVHSKVTNTRFKRRGARV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QKDAK------------------------------------------------------- ---------------------------------------------ATNVVSAQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PSTIEQGTLVWFKFQDLPFWPAV------ ------------------------------VKSVSKIDKMARVLLIEGNMQFE-RRGIRV PLRKLKHLDCGEKVSLVRRASRLYAQGINWCFSVIDHYREGLSRGSLLGSFMDYYTTQAS YPLRRAVQEGDLHIDFPKVSYAEL-E--DWEEETALGG-KGPY--------KKLLPDRMR AAWDRANQKLVDFIVKRKGAD--------------------------------------- ------------------------QHLLDIVKGRKPSRWLDDLWKSKREVFCIETYLEDD DQLHLVARHLQEV-A-KEADEALLSLARGDKVRFTMEVLFP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYSIAALDELSYKEAEEKYLRGPP------------------------- -------------------VHYR----EKELFDKTILKAAR---KRS------------- -------------------------------------------AAR-------------- ----------IRA-------------ARDPPVP--------------------------- -TP-------------------------------------------- >ENSMUSP00000085806 ------------------------------------------------------M--DSA EYVLCGWKGQLWPARVLSRPRTPANS--KRRGAPFLEVQILPVGEKMRVRSSEVRPLDKS EIISIASLA---GKESRGRGSPGQTRAYRRALKVALDVLGEGTSL--------------- ------------------------------------------------------------ ---------------------------------------------FQGGRAGG-QRTSTV ------------A---PKVPKEQASS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SSSSLGQR- -----------------------------------------------------LCLQGRN QKGQGLSQRSP-------------GKRGRPG----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------QSPAMMGSQNVP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVRAGEAQAHTAVGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PRS-------------- ------------------------------------------------------------ ---------------------------------------EMQGDVLRG------------ ----------TRVWPSYS-ETPLGKAGGNPGKRKPGTS---------------------- -KLRSLS---------APASREGTRAKNEQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QAAS----------------------------GPLR--------------------- ------------------------------------------------------------ ------------------HISISP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKKRVQC----------------------- --------AGLEIRATGAQRKTAL------------------------------A----- --------------------------------------------E-NKDHPGP------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GTPKPDSKGASAAYTPPVPKL RRSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIASQKKKPHVLCAL------------------------- ----CGLPEREPQVHSKVTNTRFKRRGARV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QKDAK------------------------------------------------------- ---------------------------------------------ATNVASAQG------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PSTIERGTLVWFKFQDLPFWPAV------ ------------------------------VKSVSENDKMARVLLIEGNMQFE-RRGIRV PLRKLKHLDCGEKVSLVRRASRLYAQGINWCFSVIDHYREGLAHGSFLGSFMDYYTTQAS YPLRRAVQEGDLHIDFPKVSYAEL-E--DWEEETALGG-KGPY--------KKLLPDRMR AAWDRANQKLVDFIVKRKGAD--------------------------------------- ------------------------QHLLDIVKGRKPSRWLDDLWKSKREVFCIETYLEDE DQLHLVARHLQEV-A-KEADEALLSLARGDKVRFTMEVLFP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDELTYKEAEEKYLRGPP------------------------- -------------------VHYR----EKELFDKTILKAAR---KRS------------- -------------------------------------------AAR-------------- ----------IRA-------------ARDPPVP--------------------------- -TP-------------------------------------------- >ENSMUSP00000079200 ------------------------------------------------------M--DSA EYVLCGWKGQLWPARVLSRPRTPANS--KRRGAPFLEVQILPVGEKMRVRSSEVRPLDKS EIISIASLA---GKESRGRGSPGQTRAYRRALKVALDVLGEGTSL--------------- ------------------------------------------------------------ ---------------------------------------------FQGGRAGG-QRTSTV ------------A---PKVPKEQASS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SSSSLGQR- -----------------------------------------------------LCLQGRN QKGQGLSQRSP-------------GKRGRPG----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------QSPAMMGSQNVP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVRAGEAQAHTAVGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PRS-------------- ------------------------------------------------------------ ---------------------------------------EMQGDVLRG------------ ----------TRVWPSYS-ETPLGKAGGNPGKRKPGTS---------------------- -KLRSLS---------APASREGTRAKNEQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QAAS----------------------------GPLR--------------------- ------------------------------------------------------------ ------------------HISISP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKKRVQC----------------------- --------AGLEIRATGAQRKTAL------------------------------A----- --------------------------------------------E-NKDHPGP------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GTPKPDSKGASAAYTPPVPKL RRSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIASQKKKPHVLCAL------------------------- ----CGLPEREPQVHSKVTNTRFKRRGARV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QKDAK------------------------------------------------------- ---------------------------------------------ATNVASAQG------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PSTIERGTLVWFKFQDLPFWPAV------ ------------------------------VKSVSENDKMARVLLIEGNMQFE-RRGIRV PLRKLKHLDCGEKVSLVRRASRLYAQGINWCFSVIDHYREGLAHGSFLGSFMDYYTTQAS YPLRRAVQEGDLHIDFPKVSYAEL-E--DWEEETALGG-KGPY--------KKLLPDRMR AAWDRANQKLVDFIVKRKGAD--------------------------------------- ------------------------QHLLDIVKGRKPSRWLDDLWKSKREVFCIETYLEDE DQLHLVARHLQEV-A-KEADEALLSLARGDKVRFTMEVLFP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDELTYKEAEEKYLRGPP------------------------- -------------------VHYR----EKELFDKTILKAAR---KRS------------- -------------------------------------------AAR-------------- ----------IRA-------------ARDPPVP--------------------------- -TP-------------------------------------------- >ENSRNOP00000060281 ------------------------------------------------------M--DSA EYVLCGWKGQLWPARVLSRPRTPAHS--KRRGTPFLEVQILPVGEKMRVRSTEVRPLTKS EIISIASLS---RKEP--RGSPGQSRAYRRALKVALDVLGEGTCL--------------- ------------------------------------------------------------ ---------------------------------------------FQGGRPGG-RRTSTV ------------A---PKIPKEQA-S---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SSSSLGQRL CLR----------------------------------------------------LQGRN QKGQGPSQRSP-------------GKRGRP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GPVLMDSQSVP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVQGGEAQAHTAVGP----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PRL-------------- ------------------------------------------------------------ ---------------------------------------VMQGRVLRG------------ ----------TRVWPSNS-EAPLGNAGGDPRKRKPVTS---------------------- -KPRSLS---------APASREGTRAKNQQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QAAS----------------------------GPPR--------------------- ------------------------------------------------------------ ------------------RISVSP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKQRVRC----------------------- --------PGLEIRAIGAQRKTAL------------------------------P----- --------------------------------------------E-NKDHPAP------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GTPKPDSKGASAACMPPIPTL RRSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIASRKRKVRVLCTQ------------------------- ----CGLPKLGPQVHSKVTNTRFKRRRAGV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PKDAQ------------------------------------------------------- ---------------------------------------------ATNVASAQG------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PSTIERGTLVWFKFQDLPFWPAV------ ------------------------------VKSVSTIDKMARVLLIEGNMQFE-RRGIRV PLRKLKHLDCGEKISLLRRARRLYAHGINWCFSVIDHYREELACGSFLGSFIDYFTTQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETTPGG-KGPH--------KKFLPDRMK AAWDRANQKLVDFIVKRKGAD--------------------------------------- ------------------------QHLMDIVKGRKPSKWLDALWKSKREVLCIETYLEDE DQLHLVARHLQEV-A-KEADKALLSLARGDIVRFTMEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIANLDELSYKEAEEKYLRGPP------------------------- -------------------VHYR----EKELFDKNILKAAR---KRS------------- -------------------------------------------AAR-------------- ----------IQA-------------ARHPPVH--------------------------- -TP-------------------------------------------- >ENSRNOP00000023222 ------------------------------------------------------M--DSA EYVLCGWKGQLWPARVLSRPRTPAHS--KRRGTPFLEVQILPVGEKMRVRSTEVRPLTKS EIISIASLS---RKEP--RGSPGQSRAYRRALKVALDVLGEGTCL--------------- ------------------------------------------------------------ ---------------------------------------------FQGGRPGG-RRTSTV ------------A---PKIPKEQA-S---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SSSSLGQRL CLR----------------------------------------------------LQGRN QKGQGPSQRSP-------------GKRGRP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GPVLMDSQSVP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVQGGEAQAHTAVGP----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PRL-------------- ------------------------------------------------------------ ---------------------------------------VMQGRVLRG------------ ----------TRVWPSNS-EAPLGNAGGDPRKRKPVTS---------------------- -KPRSLS---------APASREGTRAKNQQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QAAS----------------------------GPPR--------------------- ------------------------------------------------------------ ------------------RISVSP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKQRVRC----------------------- --------PGLEIRAIGAQRKTAL------------------------------P----- --------------------------------------------E-NKDHPAP------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GTPKPDSKGASAACMPPIPTL RRSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIASRKRKVRVLCTQ------------------------- ----CGLPKLGPQVHSKVTNTRFKRRRAGV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PKDAQ------------------------------------------------------- ---------------------------------------------ATNVASAQG------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PSTIERGTLVWFKFQDLPFWPAV------ ------------------------------VKSVSTIDKMARVLLIEGNMQFE-RRGIRV PLRKLKHLDCGEKISLLRRARRLYAHGINWCFSVIDHYREELACGSFLGSFIDYFTTQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETTPGG-KGPH--------KKFLPDRMK AAWDRANQKLVDFIVKRKGAD--------------------------------------- ------------------------QHLMDIVKGRKPSKWLDALWKSKREVLCIETYLEDE DQLHLVARHLQEV-A-KEADKALLSLARGDIVRFTMEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIANLDELSYKEAEEKYLRGPP------------------------- -------------------VHYR----EKELFDKNILKAAR---KRS------------- -------------------------------------------AAR-------------- ----------IQA-------------ARHPPVH--------------------------- -TP-------------------------------------------- >ENSCGRP00015001742 ------------------------------------------------------M--DSA EYVLCSWKGQMWPARVLSRPRTSSHS--KRRGASFLEVQILPVGEKTRVRSTEVRPLTRS EIVTIASLA---GKESQGNGSPRQTRAYRRALKVALDVLGEGTCL--------------- ------------------------------------------------------------ ---------------------------------------------HQRGRAGGQRRTSTA ------------T---LKVPEEQANS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SSH------ --------------------QRLH-------------------------------LQEHN QKGQGLSHRSP-------------GKRGRL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GPVLMGSQNEP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVQGGKAQAHTAVGP----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PHF-------------- ------------------------------------------------------------ ---------------------------------------EMQGNLLRG------------ ----------TRLWPSSY-KPPAGNAGDNPNKRKLSTS---------------------- -KLRSLS---------TPASREGARAKNEQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QAAS----------------------------GPPR--------------------- ------------------------------------------------------------ ------------------HASTSP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LQQQVRC----------------------- --------GGLEIRAIGAQRKTTL------------------------------P----- --------------------------------------------E-NKQDPGP------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RTPKPDSKGASAACTPPIPRL RRSV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIASRKRKVHVLCAQCMLPDLEIPVHSKVTSTRGKRRVAG VEEVC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----Q------------------------------------------------------- ---------------------------------------------ATNVASAQG------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PNTIERGMLVWFKFQDLPFWPAV------ ------------------------------VKSVNKNDKMARVLLIEGNMQFE-HKGVRV PLRKLKHLDCGEKSVLLRRASRVYGQAINWCLSVINHYREVLACGSFLGSFMDYYTAQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETALGG-KGPR--------KKLLPDRMR AAWDRANQKLVDFIVKRKGAD--------------------------------------- ------------------------QHLLDIVKGRKPSRWLDNLWKSKREVFCIETYLEDE DQLHLVARHLQEI-S-NEADEALLSLARGDKVRFTMEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDELSYKEAEEKYLRGPP------------------------- -------------------VHHR----EKELFDKTILKAAR---KRS------------- -------------------------------------------AAR-------------- ----------IWA-------------AKDPSAP--------------------------- -IP-------------------------------------------- >ENSCGRP00000026564 ------------------------------------------------------M--DSA EYVLCSWKGQMWPARVLSRPRTSSHS--KRRGASFLEVQILPVGEKTRVRSTEVRPLTRS EIVTIASLA---GKESQGNGSPRQTRAYRRALKVALDVLGEGTCL--------------- ------------------------------------------------------------ ---------------------------------------------HQRGRAGGQRRTSTA ------------T---LKVPEEQANS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SSH------ --------------------QRLH-------------------------------LQEHN QKGQGLSHRSP-------------GKRGRL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GPVLMGSQNEP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVQGGKAQAHTAVGP----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PHF-------------- ------------------------------------------------------------ ---------------------------------------EMQGNLLRG------------ ----------TRLWPSSY-KPPAGNAGDNPNKRKLSTS---------------------- -KLRSLS---------TPASREGARAKNEQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QAAS----------------------------GPPR--------------------- ------------------------------------------------------------ ------------------HASTSP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LQQQVRC----------------------- --------GGLEIRAIGAQRKTTL------------------------------P----- --------------------------------------------E-NKQDPGP------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RTPKPDSKGASAACTPPIPRL RRSV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIASRKRKVHVLCAQCMLPDLEIPVHSKVTSTRGKRRVAG VEEVC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----Q------------------------------------------------------- ---------------------------------------------ATNVASAQG------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PNTIERGMLVWFKFQDLPFWPAV------ ------------------------------VKSVNKNDKMARVLLIEGNMQFE-HKGVRV PLRKLKHLDCGEKSVLLRRASRVYGQAINWCLSVINHYREVLACGSFLGSFMDYYTAQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETALGG-KGPR--------KKLLPDRMR AAWDRANQKLVDFIVKRKGAD--------------------------------------- ------------------------QHLLDIVKGRKPSRWLDNLWKSKREVFCIETYLEDE DQLHLVARHLQEI-S-NEADEALLSLARGDKVRFTMEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDELSYKEAEEKYLRGPP------------------------- -------------------VHHR----EKELFDKTILKAAR---KRS------------- -------------------------------------------AAR-------------- ----------IWA-------------AKDPSAP--------------------------- -IP-------------------------------------------- >ENSCGRP00015003500 ------------------------------------------------------M--DSA EYVLCSWKGQMWPARVLSRPRTSSHS--KRRGASFLEVQILPVGEKTRVRSTEVRPLTRS EIVTIASLA---GKESQGNGSPRQTRAYRRALKVALDVLGEGTCL--------------- ------------------------------------------------------------ ---------------------------------------------HQRGRAGGQRRTSTA ------------T---LKVPEEQANS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SSH------ --------------------QRLH-------------------------------LQEHN QKGQGLSHRSP-------------GKRGRL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GPVLMGSQNEP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVQGGKAQAHTAVGP----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PHF-------------- ------------------------------------------------------------ ---------------------------------------EMQGNLLRG------------ ----------TRLWPSSY-KPPAGNAGDNPNKRKLSTS---------------------- -KLRSLS---------TPASREGARAKNEQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QAAS----------------------------GPPR--------------------- ------------------------------------------------------------ ------------------HASTSP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LQQQVRC----------------------- --------GGLEIRAIGAQRKTTL------------------------------P----- --------------------------------------------E-NKQDPGP------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RTPKPDSKGASAACTPPIPRL RRSV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIASRKRKVHVLCAQCMLPDLEIPVHSKVTSTRGKRRVAG VEEVC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----Q------------------------------------------------------- ---------------------------------------------ATNVASAQG------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PNTIERGMLVWFKFQDLPFWPAV------ ------------------------------VKSVNKNDKMARVLLIEGNMQFE-HKGVRV PLRKLKHLDCGEKSVLLRRASRVYGQAINWCLSVINHYREVLACGSFLGSFMDYYTAQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETALGG-KGPR--------KKLLPDRMR AAWDRANQKLVDFIVKRKGAD--------------------------------------- ------------------------QHLLDIVKGRKPSRWLDNLWKSKREVFCIETYLEDE DQLHLVARHLQEI-S-NEADEALLSLARGDKVRFTMEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDELSYKEAEEKYLRGPP------------------------- -------------------VHHR----EKELFDKTILKAAR---KRS------------- -------------------------------------------AAR-------------- ----------IWA-------------AKDPSAP--------------------------- -IP-------------------------------------------- >ENSCGRP00015003495 ------------------------------------------------------M--DSA EYVLCSWKGQMWPARVLSRPRTSSHS--KRRGASFLEVQILPVGEKTRVRSTEVRPLTRS EIVTIASLA---GKESQGNGSPRQTRAYRRALKVALDVLGEGTCL--------------- ------------------------------------------------------------ ---------------------------------------------HQRGRAGGQRRTSTA ------------T---LKVPEEQANS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SSH------ --------------------QRLH-------------------------------LQEHN QKGQGLSHRSP-------------GKRGRL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GPVLMGSQNEP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVQGGKAQAHTAVGP----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PHF-------------- ------------------------------------------------------------ ---------------------------------------EMQGNLLRG------------ ----------TRLWPSSY-KPPAGNAGDNPNKRKLSTS---------------------- -KLRSLS---------TPASREGARAKNEQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QAAS----------------------------GPPR--------------------- ------------------------------------------------------------ ------------------HASTSP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LQQQVRC----------------------- --------GGLEIRAIGAQRKTTL------------------------------P----- --------------------------------------------E-NKQDPGP------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RTPKPDSKGASAACTPPIPRL RRSV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIASRKRKVHVLCAQCMLPDLEIPVHSKVTSTRGKRRVAG VEEVC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----Q------------------------------------------------------- ---------------------------------------------ATNVASAQG------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PNTIERGMLVWFKFQDLPFWPAV------ ------------------------------VKSVNKNDKMARVLLIEGNMQFE-HKGVRV PLRKLKHLDCGEKSVLLRRASRVYGQAINWCLSVINHYREVLACGSFLGSFMDYYTAQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETALGG-KGPR--------KKLLPDRMR AAWDRANQKLVDFIVKRKGAD--------------------------------------- ------------------------QHLLDIVKGRKPSRWLDNLWKSKREVFCIETYLEDE DQLHLVARHLQEI-S-NEADEALLSLARGDKVRFTMEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDELSYKEAEEKYLRGPP------------------------- -------------------VHHR----EKELFDKTILKAAR---KRS------------- -------------------------------------------AAR-------------- ----------IWA-------------AKDPSAP--------------------------- -IP-------------------------------------------- >ENSCGRP00015005143 ------------------------------------------------------M--DSA EYVLCSWKGQMWPARVLSRPRTSSHS--KRRGASFLEVQILPVGEKTRVRSTEVRPLTRS EIVTIASLA---GKESQGNGSPRQTRAYRRALKVALDVLGEGTCL--------------- ------------------------------------------------------------ ---------------------------------------------HQRGRAGGQRRTSTA ------------T---LKVPEEQANS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SSH------ --------------------QRLH-------------------------------LQEHN QKGQGLSHRSP-------------GKRGRL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GPVLMGSQNEP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVQGGKAQAHTAVGP----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PHF-------------- ------------------------------------------------------------ ---------------------------------------EMQGNLLRG------------ ----------TRLWPSSY-KPPAGNAGDNPNKRKLSTS---------------------- -KLRSLS---------TPASREGARAKNEQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QAAS----------------------------GPPR--------------------- ------------------------------------------------------------ ------------------HASTSP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LQQQVRC----------------------- --------GGLEIRAIGAQRKTTL------------------------------P----- --------------------------------------------E-NKQDPGP------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RTPKPDSKGASAACTPPIPRL RRSV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIASRKRKVHVLCAQCMLPDLEIPVHSKVTSTRGKRRVAG VEEVC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----Q------------------------------------------------------- ---------------------------------------------ATNVASAQG------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PNTIERGMLVWFKFQDLPFWPAV------ ------------------------------VKSVNKNDKMARVLLIEGNMQFE-HKGVRV PLRKLKHLDCGEKSVLLRRASRVYGQAINWCLSVINHYREVLACGSFLGSFMDYYTAQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETALGG-KGPR--------KKLLPDRMR AAWDRANQKLVDFIVKRKGAD--------------------------------------- ------------------------QHLLDIVKGRKPSRWLDNLWKSKREVFCIETYLEDE DQLHLVARHLQEI-S-NEADEALLSLARGDKVRFTMEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDELSYKEAEEKYLRGPP------------------------- -------------------VHHR----EKELFDKTILKAAR---KRS------------- -------------------------------------------AAR-------------- ----------IWA-------------AKDPSAP--------------------------- -IP-------------------------------------------- >ENSCGRP00001004164 ------------------------------------------------------M--DSA EYVLCSWKGQMWPARVLSRPRTSSHS--KRRGASFLEVQILPVGEKTRVRSTEVRPLTRS EIVTIASLA---GKESQGNGSPRQTRAYRRALKVALDVLGEGTCL--------------- ------------------------------------------------------------ ---------------------------------------------HQRGRAGGQRRTSTA ------------T---LKVPEEQANS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SSH------ --------------------QRLH-------------------------------LQEHN QKGQGLSHRSP-------------GKRGRL------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GPVLMGSQNEP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVQGGKAQAHTAVGP----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PHF-------------- ------------------------------------------------------------ ---------------------------------------EMQGNLLRG------------ ----------TRLWPSSY-KPPAGNAGDNPNKRKLSTS---------------------- -KLRSLS---------TPASREGARAKNEQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QAAS----------------------------GPPR--------------------- ------------------------------------------------------------ ------------------HASTSP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LQQQVRC----------------------- --------GGLEIRAIGAQRKTTL------------------------------P----- --------------------------------------------E-NKQDPGP------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RTPKPDSKGASAACTPPIPRL RRSV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIASRKRKVHVLCAQCMLPDLEIPVHSKVTSTRGKRRVAG VEEVC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----Q------------------------------------------------------- ---------------------------------------------ATNVASAQG------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PNTIERGMLVWFKFQDLPFWPAV------ ------------------------------VKSVNKNDKMARVLLIEGNMQFE-HKGVRV PLRKLKHLDCGEKSVLLRRASRVYGQAINWCLSVINHYREVLACGSFLGSFMDYYTAQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETALGG-KGPR--------KKLLPDRMR AAWDRANQKLVDFIVKRKGAD--------------------------------------- ------------------------QHLLDIVKGRKPSRWLDNLWKSKREVFCIETYLEDE DQLHLVARHLQEI-S-NEADEALLSLARGDKVRFTMEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDELSYKEAEEKYLRGPP------------------------- -------------------VHHR----EKELFDKTILKAAR---KRS------------- -------------------------------------------AAR-------------- ----------IWA-------------AKDPSAP--------------------------- -IP-------------------------------------------- >ENSPEMP00000035164 ------------------------------------------------------M--DSA EYVLCGWKGQLWPARVLSRPGTSAHR--KRRGASFLEVQILPVGEKTRVRSTEARPLTKS ETVTIASLA---GKESQGKSSPRQTRAYRKALKVALDVLGEGTCL--------------- ------------------------------------------------------------ ---------------------------------------------YQGGRAGG-RRTSTA ------------A---PKVPKEQASS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SPR------ --------------------QRLH-------------------------------LQGRN QKGQGLSHRSP-------------GKWGRP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GSVWMGSPNMP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVQGGKARAHSAVGH----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------AHF-------------- ------------------------------------------------------------ ---------------------------------------EMQGNMPRR------------ ----------TRVWPGSC-KTPAGNAGDNPSKRKLSTS---------------------- -KLRSLS---------APASREGARDKNEQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QAAS----------------------------GPPR--------------------- ------------------------------------------------------------ ------------------HVSTLP-RA--------------------------------- ------------------------------------------------------------ ------------------------------PKQQVRC----------------------- --------GSLEIRAIGAQRKTTL------------------------------P----- --------------------------------------------E-NEEDPGR------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GTPKPDSKGASAACMPPIPRL RRSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIATRKRKIHVLCAQ------------------------- ----CGLPELATKMHSKATNTGVKRRAAGV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEDRQ------------------------------------------------------- ---------------------------------------------ATNVASAQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PSTIERGMLVWFKFQDLPFWPAV------ ------------------------------VKSVSKNGKMARVLLIEGNMQFE-HRGVRV PLRKLKHLDCGAKLSLLRRASRVYSQGISWCLSVIDHYKEDLACGSFLGSFMDYYTSQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETALGG-KGPR--------KKLLPDRMR AAWDRANQKLVDFIVKRKGAD--------------------------------------- ------------------------QHLRDIVKGRKPSRWLDDLWKSKREVFCIETYLEDE DQLHLVARHLQEI-S-KEADEALLSLARGDKVRFTMEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDELSYKEAEEKYLRGPP------------------------- -------------------VHYR----EKELFDKTILKAAR---MRS------------- -------------------------------------------ASR-------------- ----------IRA-------------ARNPSAP--------------------------- -SP-------------------------------------------- >ENSMUGP00000029457 ------------------------------------------------------M--DSA EYVLCGWKGQLWPARVLSRPRISAHS--KRRGAPYLEVQILPMGEKTRVRSTEVRPLTKS EIVTIASTA---GKESQGSSFPGQTRAYKRALKVALDILGEGDSL--------------- ------------------------------------------------------------ ---------------------------------------------FQGGRADG-QRTSTM ------------AL--EKVPEKQASS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SPR------ --------------------QCLR-------------------------------LQGHN QKGQGLSQRGPVKQDCHPDPVLPVG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------SQKVP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----LVQGGKAQTHTAVGP----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PHF-------------- ------------------------------------------------------------ ---------------------------------------EMQGNVLRGIKEGSRYSATAG NAGHNLGMKR------------------------LSTS---------------------- -KLGPLS---------APTSQEGAQAKNEQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QAAS----------------------------RPPR--------------------- ------------------------------------------------------------ ------------------RLSTLP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKQQTGC----------------------- --------AGLEIWVTGVQGKTTL------------------------------P----- --------------------------------------------E-NKEDPCL------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GTLRPAANRATTACMPPIPRL RRSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIASKKRKMHVTCPQ------------------------- ----CRFPGVQPQVHSKVTNTRFKRWGTGI------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ QEGGQ------------------------------------------------------- ---------------------------------------------ATKVVSAQL------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PNTIEQGMLVWFKFQDLPFWPAV------ ------------------------------VKSVSQKDKMASVLLIEGNMQFE-HRGVRV PLHKLKHLDCGEKISLMKRASRMYKHGISWCFSVIDHYREGLACGSFLGSFMDYYTAQAS YPLRRAIQNGDLHIDFPKVSYADL-E--DWEEETALGG-KRPH--------KKLLPDRMR AAWDRANQKLVDFIVKRKGAD--------------------------------------- ------------------------QHLRDIMKGRKQSRWLDKLWKSKKEVFCIETYLEDE EQLHLVARHLQEI-A-KEADEALLSLTRGDKVRFTMEVLFP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDELSYKKAEEKYLRGPP------------------------- -------------------VHYR----EKELFDKTILKAAR---KRP------------- -------------------------------------------AAR-------------- ----------IQA-------------SRNPPAP--------------------------- -TP-------------------------------------------- >ENSOARP00000006721 ------------------------------------------------------M--DT- RYVLCVWKGRFWPAKVLSRPSVSPQQ--KRKRALSREVQILSVDEKVRVKKTKMKTLKES MIESISTSL---AAQPEPSAPEEEEMAYICAITMAWDLLHKNGNVTP-A----------- --------------------------RVTGDPESKT------------------------ ---------QSP----------------RRLQKQHRSRCQEPSRGL--------R----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------RSVRKRK------------------------------------------- ---------------------------------------SSKS-PVVPSERE-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GPDGDKPQVCTPIAPIPSEMQ----------------------------------- ------------------------------------------------------------ ---------TESSQSSGVHPNFPSLS-ED----DH------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEG----------------- -------------------------------KEKGDAS---------------------- -KVMSLP---------CTVEEVGVDVRGGC------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---VLPS----------------------------FTPG--------------------- ------------------------------------------------------------ ------------------FILTVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LEEGAH------------------------ ---------------------NTC------------------------------P--KSL AVSPERAT----------------------------------SSV-NV-DRGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GTCNSGSEGAAASSSAPNL-- --SL---------------------------------------CN--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SFRLANSKRKLQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------APGCEEEWQESQPSAGSKAIKPTNAIKEGGG KEAGQ------------------------------------------------------- ---------------------------------------------LTSMAFPEE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LCPIERGMLVWFKFQNHPFWPAV------ ------------------------------VTSVSPTEQTARVLLIEANMHCE-KSGIQV PLRRLKHLDYNGKEKLMKRASKVYGESVNWCFSLISSYREGLVRGSFVGSFLDYYAADLS YPMRKAIQEGDLQMDFPKVNYSDL-E--DSEEETPVAA-KRHC--------KRILPDRMR AARDRANQKLVDFIVKTKGAD--------------------------------------- ------------------------PHLLDIVKGRKESKWLESFLNSERYVICVETYLEDD NQLDAVVRHLREI-Y-RHIDKRALALTRDDPVSFLLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIATVDGLDYKEAEAKYRQGPP------------------------- -------------------VHYR----EKELFDKKILKKIR---KRS------------- -------------------------------------------AER-------------- ----------NKA-------------KPYPCAQ--------------------------- -QG-------------------------------------------- >ENSBBBP00000012806 M-----------------------------------------------------M--DT- RYVLCVWKGRFWPAKVLSRPSVSPQQ--KRKRALSLEVQILSIDEKIRVKKTKIKTLKES MIESISTSL---AAQPEPIAPEEEEMAYICAITMAWDVLNKNGNFTP-A----------- --------------------------RVAGDPESKM------------------------ ---------QSP----------------RRLQKQHCRRCQKPKRGL--------R----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------RSVRKSK------------------------------------------- ---------------------------------------SSKS-PVVPSERE-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GPYGDKPQVCTPIAPIPTEMQ----------------------------------- ------------------------------------------------------------ ---------TESPQSSGVHPSFLSLS-ED----DR------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEG----------------- -------------------------------KEKQDAS---------------------- -KVMSLP---------CTVKEVGVDVRGER------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---VLPS----------------------------LTPG--------------------- ------------------------------------------------------------ ------------------FILTVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------PEEGVH------------------------ ---------------------NTC------------------------------P--KSL AVSPERAT----------------------------------SSV-NV-DPEE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GTCNSGSEGAEASSNASNLGL RYSL---------------------------------------C---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------LANRKRKLQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------APGCEEEQQESQPSAGSKAIKPTGAIKKGGG KEVGQ------------------------------------------------------- ---------------------------------------------LTSMACPEE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LCPIERGMLVWFKFQNHPFWPAV------ ------------------------------VKSVSPTEQTARVLLIEANMHCE-KSGIQV PLRRLKHLDYNGKEKLMKRASKVYGASVNWCFSLISSYREGLVRGSFVGSFLDYYAADIS YPMRKAIQEGDLQMDFPKVNYSDL-E--DSEEETP----QRHC--------KRILPDRMR AAWDRANEKLVDFIVNRKGAD--------------------------------------- ------------------------PHLLDIVKGRKESKWLESFRNSERYVICVETYLEDD DQLDAVVRHLQEI-Y-KHIDKKALALTRDDPVSFLLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIATMDGLDYKEAEAKYRQGPP------------------------- -------------------VRYR----EKELFDKKILKKIK---KRS------------- -------------------------------------------AERYKFARLPYPSPTPG ACSNSCPSSQ-------------------------------------------------- ----------------------------------------------- >ENSBTAP00000032621 ------------------------------------------------------M--DT- RYVLCVWKGRFWPAKVLSRPSVSPQQ--KRKRALSLEVQILSIDEKIRVKKTKIKTLKES MIESISTSL---AAQPEPIAPEEEEMAYICAITMAWDVLNKNGNFTP-A----------- --------------------------RVAGDPESKM------------------------ ---------QSP----------------RRLQKQHCRRCQKPKRGL--------R----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------RSVRKSK------------------------------------------- ---------------------------------------SSKS-PVVPSERE-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GPYGDKPQVCTPIAPIPTEMQ----------------------------------- ------------------------------------------------------------ ---------TESSQSSGVHPSFLSLS-ED----DR------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEG----------------- -------------------------------KEKQDAS---------------------- -KVMSLP---------CTVKEVGVDVRGER------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---VLPS----------------------------LTPG--------------------- ------------------------------------------------------------ ------------------FILTVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------PEEGVH------------------------ ---------------------NTC------------------------------P--KSL AVSPERAT----------------------------------SSV-NV-DPEE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GTCNSGSEGAEASSNASNLGL RYSL---------------------------------------C---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------LANRKRKLQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------APGCEEEQQESQPSAGSKAIKPTSAIKKGGG KEVGQ------------------------------------------------------- ---------------------------------------------LTSMACPEE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LCPIERGMLVWFKFQNHPFWPAV------ ------------------------------VKSVSPTEQTARVLLIEANMHCE-KSGIQV PLRRLKHLDYNGKEKLMKRASKVYGASVNWCFSLISSYREGLVRGSFVGSFLDYYAADIS YPMRKAIQEGDLQMDFPKVNYSDL-E--DSEEETPVAA-KRHC--------KRILPDRMR AAWDRANEKLVDFIVNRKGAD--------------------------------------- ------------------------PHLLDIVKGRKESKWLESFLHSERYVICVETYLEDD DQLDAVVRHLQEI-Y-KHIDKKALALTRDDPVSFLLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIATMDGLDYKEAEAKYRQGPP------------------------- -------------------VRYR----EKELFDKKILKKIK---KRS------------- -------------------------------------------AERYKFARLPYPSPTPG ACSNSCPSSQ-------------------------------------------------- ----------------------------------------------- >ENSBMUP00000031371 M-----------------------------------------------------M--DT- RYVLCVWKGRFWPAKVLSRPSVSPQQ--KRKRALSLEVQILSIDEKIRVKKTKIKTLKES MIESISTSL---AAQPEPSAPEEEEMAYICAITMAWDVLNKNGNFTP-A----------- --------------------------RVAGDPESKM------------------------ ---------QSP----------------RRLQKQHCRRCQKPKRGL--------R----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------RSVRKSK------------------------------------------- ---------------------------------------SSKS-PVVPSERE-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GPYGDKPQVCTPIAPIPTEMQ----------------------------------- ------------------------------------------------------------ ---------TESPQSSGVHPSFLSLS-ED----DR------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEG----------------- -------------------------------KEKQDAS---------------------- -KVMSLP---------CTVKEVGVDVRGER------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---VLPS----------------------------LTPG--------------------- ------------------------------------------------------------ ------------------FIFTVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------PEEGVH------------------------ ---------------------NTC------------------------------P--KSL AVSPERAT----------------------------------SSV-NV-DPEE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GTCNSGSEGAEASSNASNLGL RYSL---------------------------------------C---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------LANRKRKLQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------APGCEEEQQESQPSAGSKAIKPTSAIKKGGG KEVGQ------------------------------------------------------- ---------------------------------------------LTSMACPEE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LCPIERGMLVWFKFQNHPFWPAV------ ------------------------------VKSVSPTEQTARVLLIEANMHCE-KSGIQV PLRRLKHLDYNGKEKLMKRASKVYGASVNWCFSLISSYREGLVRGSFVGSFLDYYAADIS YPMRKAIQEGDLQMDFPKVNYSDL-E--DSEEETPVAA-KRHC--------KRILPDRMR AAWDRANEKLVDFIVNRKGAD--------------------------------------- ------------------------PHLLDIVKGRKESKWLESFLNSERYVICVETYLEDD DQLDAVVRHLQEI-Y-KHIDKKALALTRDDPVSFLLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIATMDGLDYKEAEAKYRQGPP------------------------- -------------------VRYR----EKELFDKKILKKIK---KRS------------- -------------------------------------------AERYKFARLPYPSPTPG ACSNSCPSSQ-------------------------------------------------- ----------------------------------------------- >ENSVVUP00000002542 ------------------------------------------------------M--DA- NYVLCNWKGHLWPARVLSRSGVSPRN--KRKGALSLEVEILSVVEKIKVKSTDVKILNES QIESITSLL---TAQSKASVPAGQEAPYRNALTMPLEILKERADVRP-G----------- --------------------------GASDGPE--------------------------- --------------------------------------------------------TTTP ------------SR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RGP-------------RKRSLKNYRKAKGI---------------------- ------------------------------------------------------------ --------LLRRLRKRR------------------------------------------- ---------------------------------------NLKS-RLVHSQRP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APDGGQSQAHTTITPLPRKRR----------------------------------- ------------------------------------------------------------ ---------AKSSPSSSRHPNLLALS-EA----GG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEG----------------- -------------------------------KEKRDTS---------------------- -RVRSSH---------GIAKEEGTGAEDGG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---ILPS----------------------------PPPG--------------------- ------------------------------------------------------------ ------------------LNLTVPEEA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEAP------------------------ ---------------------DTH------------------------------A--QTP AASSERSA----------------------------------SSG-NVEDHGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPWEPGLEGVAPSSSAPNLRP RCSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RLANRRRKLQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VPEFEKGLQESRPSASSKAVNPTTAIKKDVS QEMGQ------------------------------------------------------- ---------------------------------------------VTSTLSPQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCPIEGGMMVWFKFQNHPFWPAV------ ------------------------------VKSVSQAEQTARVLLIEANMHAE-MSGIRV PLRRLKPLDCIEKETLMKRARKVYEQSVNWCFSLISHYREGLTCGSFAGSFLDYYSADVS YPVRKAIQDGDLEADFPKVNYADL-E--DYEEETSVGG-KRPP--------KKILPDRMR AAWDRANQRLVDFIVKTKGAD--------------------------------------- ------------------------HHLLDIVKGRKQSRWLTSFLNSNRYTLCIETYLEDE DQLDVVVGHLQEI-Y-KQIDKKRLSLAREDKVSFVVEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDGLGYKEAEAKYLRGPP------------------------- -------------------VHYW----EKELFDKSILKKMR---KRS------------- -------------------------------------------APR-------------- ----------RKA------------NK--------------------------------- ----------------------------------------------- >ENSVVUP00000041787 ------------------------------------------------------M--DA- EYVLCNWKGHLWPARVLSRPGVSPRN--KRKGALSLEVEILSVDEKIKVKSTDVKILNES QIESITSLL---TAQSKASVPAGQEAPYRNALTMPLEILKERADVRP-G----------- --------------------------GASDGPE--------------------------- --------------------------------------------------------TTTP ------------SR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RGP-------------RKRSLKNYRKAKGI---------------------- ------------------------------------------------------------ --------LLRRLRKRR------------------------------------------- ---------------------------------------NLKS-RLVHSQRP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APDGGQSQAHTTITPLPRKRR----------------------------------- ------------------------------------------------------------ ---------AKSSPSSSRHPNLLALS-EA----GG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEG----------------- -------------------------------KEKRDTS---------------------- -RVRSSH---------GIAKEEGTGAEDGG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---ILPS----------------------------PPPG--------------------- ------------------------------------------------------------ ------------------LNLTVPEEA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEAP------------------------ ---------------------DTH------------------------------A--QTP AASSERSA----------------------------------SSG-NVEDHGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPWEPGLEGVAPSSSAPNLRP RCSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RLANRRRKLQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VPEFEKGLQESRPSASSKAVNPTTAIKKDVS QEMGQ------------------------------------------------------- ---------------------------------------------VTSTLSPQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCPIEGGMMVWFKFQNHPFWPAV------ ------------------------------VKSVSQAEQTARVLLIEANMHAE-MSGIRV PLRRLKPLDCIEKETLMKRARKVYEQSVNWCFSLISHYREGLTCGSFAGSFLDYYAADVS YPVRKAIQDGDLEAEFPKVNYADL-E--DSDEETSVGG-KRPR--------QKILPDRMR AARDRANQRLVDFIVKRKGAD--------------------------------------- ------------------------HHLLDIVKGKKQSRWLTSFLNSKRYTLCIETYLEDE DQLDVVVGHLQEI-Y-KQIDRKRLTLARDDKVSFVVEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDGLGYKEAEEKYLQGPP------------------------- -------------------VHYR----EKQLFDNNILKQMR---KRS------------- -------------------------------------------APG-------------- ----------LKA------------NK--------------------------------- ----------------------------------------------- >ENSCAFP00000040849 ------------------------------------------------------M--DA- EYVLCNWKGHLWPARVLSRSGVSPRN--KRKGALSLEVEILSVDEKMKVKSTDVKILNES QIESITSLL---TAQSKASVPAGQEVPYRNALSVALEILKERADVRP-A----------- --------------------------GASDDPE--------------------------- --------------------------------------------------------TTTP ------------SR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RGP-------------RKRSLKDYRKAKGI---------------------- ------------------------------------------------------------ --------LLRRLRKRR------------------------------------------- ---------------------------------------NLKS-RLGHSQRP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TTEGGQSQAHTTLTPLPRKRQ----------------------------------- ------------------------------------------------------------ ---------AKSSPSSSRRPNLPSLS-ED----GG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEG----------------- -------------------------------KEKRDTS---------------------- -RVRSLH---------RIAKEAGTGAEDGG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---ILPS----------------------------PPPG--------------------- ------------------------------------------------------------ ------------------FNLTVPEEA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEAP------------------------ ---------------------DTH------------------------------A--KNP AASSERSA----------------------------------SSR-NVEDHGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPWEPGMEGAAASSSAPNLRP RCSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RLANRRRKLQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VPEFEKGLQESRPSASSKAVNPTTAIKKDVS QEMGQ------------------------------------------------------- ---------------------------------------------LTSTLSPQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCPIEGGMMVWFKFQNHPFWPAV------ ------------------------------VKSVSQAEQTARVLLIEANMHAE-MSGIRV PLRRLKPLDFKEKETLMKRARKMYEQSVNWCFSLISHYREGLTCGSFAGSFLDYYAADVS YPVRKAIQDGDLEADFPKVNYADL-E--DSEEETSVGG-KRPR--------KKILPDRMR AARDRANQRLVDFIVKTKGAD--------------------------------------- ------------------------HHLLDIVKGRKQSRWLTSFLNSNRYTLCVETYLEDE DQLDVVVGHLQEI-Y-KQIDKKRLTLARDDKVSFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDGLGYKEAEEKYLRGPP------------------------- -------------------VHYR----EKELFDKNILKKMR------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSCAFP00000035555 ------------------------------------------------------M--DA- EYVLCNWKGHLWPARVLSRSGVSPRN--KRKGALSLEVEILSVDEKIKVKSTDVKILNES QIESITSLL---TAQSKASVPAGQEVPYRNALSVALEILKERADVRP-A----------- --------------------------GASDDPE--------------------------- --------------------------------------------------------TTTP ------------SR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RGP-------------RKRSLKDYRKAKGI---------------------- ------------------------------------------------------------ --------LLRRLRKRR------------------------------------------- ---------------------------------------NLKP-RLVHSQRP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TTEGGQSQAHTTITPLPRKRR----------------------------------- ------------------------------------------------------------ ---------AKSSPSSSRRPNLPSLS-ED----GG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEG----------------- -------------------------------KEKRDTS---------------------- -RVRSLH---------RIAKEGGTGAEDGG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---ILPS----------------------------PPPG--------------------- ------------------------------------------------------------ ------------------FNLTVPEEA--------------------------------- ------------------------------------------------------------ ------------------------------LKDEAP------------------------ ---------------------DTH------------------------------A--KNP AASSERSA----------------------------------SSR-NVEDHGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPWEPGMEGAAASSSAPNLRP RCSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RLANRRRKLQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VPEFEKGLQESRPSASSKAVNPTTAIKKDVS QEMGQ------------------------------------------------------- ---------------------------------------------LTSTLSPQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCPIEGGMMVWFKFQNHPFWPAV------ ------------------------------VKSVSQAEQTARVLLIEANMHAE-MSGIRV PLRRLKPLDCKEKETLMKRARKMYEQSVNWCFSLISHYREGLTCGSFAGSFLDYYAADVS YPVRKAIQDGDLEADFPKVNYADL-E--DSEEETSVGG-KRPR--------KKILPDRMR AARDRANQRLVDFIVKTKGAD--------------------------------------- ------------------------HHLLDIVKGRKQSRWLTSFLNSNRYTLCVETYLEDE DQLDVVVGHLQEI-Y-KQIDKKRLTLARDDKVSFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDGLGYKEAEEKYLRGPP------------------------- -------------------VHYR----EKELFDKNILKKMR------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSCAFP00000031828 ------------------------------------------------------M--DA- EYVLCNWKGHLWPARVLSRSGVSPRN--KRKGALSLEVEILSVDEKIKVKSTDVKILNES QIESITSLL---TAQSKASVPAGQEVPYRNALTVALEILKERADVCP-A----------- --------------------------GASDDPE--------------------------- --------------------------------------------------------TTTP ------------SR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RGP-------------RKRSLKDYRKAKGI---------------------- ------------------------------------------------------------ --------LLRRLRKRR------------------------------------------- ---------------------------------------NLKP-RLVHSQRP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TTEGGQSQAHTTITPLPRKRR----------------------------------- ------------------------------------------------------------ ---------AKSSPSSSRRPNLPSLS-ED----GG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEG----------------- -------------------------------KEKRDTS---------------------- -RVRSLH---------RIAKEGGTGAEDGG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---ILPS----------------------------PPPG--------------------- ------------------------------------------------------------ ------------------FNLTVPEEA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEAP------------------------ ---------------------DTH------------------------------T--KNP AASSERSA----------------------------------SSR-NVEDHGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPWEPGMEGAAASSSAPNLRP RCSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RLVNRRRKLQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VPEFEKGLQESRPSASSKAVNPTTAIKKDVS QEMGQ------------------------------------------------------- ---------------------------------------------LTSTLSPQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCPIEGGMMVWFKFQNHPFWPAV------ ------------------------------VKSVSQAEQTARVLLIEANMHAE-MSGIRV PLRRLKPLDFKEKETLMKRARKMYEQSVNWCFSLISHYREGLTCGSFAGSFLDYYAADVS YPVRKAIQDGDLEADFPKVNYADL-E--DSEEETSVGG-KRPR--------KKILPDRMR AARDRANQRLVDFIVKKKGAD--------------------------------------- ------------------------HHLLDIVKGRKQSRWLTSFLNSKRYTLCIETYLEDE DQLDVVVGHLQEI-Y-KQIDKKRLTLARDDKVSFVVEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDGLGYKEAEEKYLRGPP------------------------- -------------------VHYR----EKQLFDKNILKKMR---KRS------------- -------------------------------------------APG-------------- ----------LKA------------NK--------------------------------- ----------------------------------------------- >ENSCAFP00020014518 IT----------------------------------------------------M--DA- EYVLCNWKGHLWPARVLSRSGVSPRN--KRKGALSLEVEILSVDEKMKVKSTDVKILNES QIESITSLL---TAQSKASVPAGQEVPYRNALSVALEILKERADVRP-A----------- --------------------------GASDDPE--------------------------- --------------------------------------------------------TTTP ------------SR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RGP-------------RKRSLKDYRKAKGI---------------------- ------------------------------------------------------------ --------LLRRLRKRR------------------------------------------- ---------------------------------------NLKS-RLVHSRRQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APDGGQSQAHTTLTPLPRKRQ----------------------------------- ------------------------------------------------------------ ---------AKSSPSSSRRPNLPSLS-ED----GG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEG----------------- -------------------------------KEKRDTS---------------------- -RVRSLH---------RIAKEAGTGAEDGG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---ILPS----------------------------PPPG--------------------- ------------------------------------------------------------ ------------------FNLTVPEEA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEAP------------------------ ---------------------DTH------------------------------A--KTP DASSERSA----------------------------------SSG-NVEDHGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPWEPGMEGAAASSSAPNLRP RCSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RLANRRRKLQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VPEFEKGLQESRPSASSKAVNPTTAIKKDVS QEMGQ------------------------------------------------------- ---------------------------------------------LTSTLSPQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCPIEGGMMVWFKFQNHPFWPAV------ ------------------------------VKSVSQAEQTARVLLIEANMHAE-MSGIRV PLRRLKPLDCKEKETLMKRARKMYEQSVNWCFSLISHYREGLTCGSFAGSFLDYYAADVS YPVRKAIQDGDLEADFPKVNYADL-E--DSEEETSVGG-KRPR--------KKILPDRMR AARDRANQRLVDFIVKTKGAD--------------------------------------- ------------------------HHLLDIVKGRKQSRWLTSFLNSNRYTLCVETYLEDE DQLDVVVGHLQEI-Y-KQIDKKRLTLARDDKVSFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDGLGYKEAEEKYLRGPPVVRTLSLLECHVCLRHPLKRADMPR TCISSPPQRSHVNQDHIRDV---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSMPUP00000018864 ------------------------------------------------------M--DA- EYVLCNWKGHVWPAKVLSRARTSPRH--KRKGALFLEVEILSVDEKIKVKTADTKILNES QIEYVASLL---IAEPKASVPPGQEVPYRNALAVALEILNERANLGP-A----------- --------------------------RASDDPETT------------------------- ------------------------------------------------------KGTTKA ------------SQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RGP-------------QKRSRRKFRKPKGS---------------------- ------------------------------------------------------------ --------LLRRLRRSK------------------------------------------- ---------------------------------------TLRS-LLVCSQAE-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APGGGQPQAHRAVTPIPRKTR----------------------------------- ------------------------------------------------------------ ---------AEPSQSSSVYPNFPSRA-EE----DY------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEG----------------- -------------------------------KGKRHTL---------------------- -RVRALH---------RPVKEEGTGAKDGG------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TLRS----------------------------PPPG--------------------- ------------------------------------------------------------ ------------------FNLTVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEAH------------------------ ---------------------DTY------------------------------P--KTL AVSSEGSA----------------------------------LSG-NVEDHGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPRKPGLEGAAAPSSAPPPTL RYSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RLANKKRKLQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VLEFEKGLQGLQPSVNSKAINPTTAIRKDVG KEMGQ------------------------------------------------------- ---------------------------------------------PISMAFPQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCPIEGGMMVWFKFQNHPFWPAV------ ------------------------------VKSVSQTEQTARVLLIEANMPCE-TSGIQV PLRRLKHLDCKEKEKLMKRAGKVYEHSVNWCFSLISHYREGLGRGSFAGSFLDYYAADIS YPIRKAIKDGDVEIDFPKVNYADL-E--DSEEEASLGG-RRPH--------KKILPDRMR AARDRANQKLVDFIVKRKGAD--------------------------------------- ------------------------HHLLDIVKGRKQSRWLASFLNSSRYVICIETYLEDE DQLDVVVRHLQEI-Y-KQIDKKTLTLARDDKVSFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDGLGYEEAEQKYLKGPP------------------------- -------------------VHYR----EKELFDKNIVKGMR---KRA------------- -------------------------------------------ATR-------------- ----------GKA-------------K--------------------------------- ----------------------------------------------- >ENSMLUP00000021546 ------------------------------------------------------M--DS- EYVLCNWKGRFWPARVLSRSETSPKS--KGKKICSLEVQILSVGKKVKVKNRDIKILDES QIESITASL---GAQTTARVPPGEGEAYKSALTIALEILKERANLGA-A----------- --------------------------RASDDPE--------------------------- --------------------------------------------------------TPTM ------------SQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------KGT-------------QKRSHKKFPKPKGN---------------------- ------------------------------------------------------------ --------SPRSLRKSK------------------------------------------- ---------------------------------------NPKS-LLVGSEGE-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEGDKSQVHTPLAPAPKRRR----------------------------------- ------------------------------------------------------------ ---------GRPPQSRSMCSNFPPLS-ED----ER------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ETEG----------------- -------------------------------QAKTGTS---------------------- -RVRSQH---------VTAKEEAAGAQEGS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---ILPS----------------------------QPPG--------------------- ------------------------------------------------------------ ------------------LSVTVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------RKRKAP------------------------ --------------------RSTC------------------------------P--KTL AVSSEGSP----------------------------------SSG-NIEDPEE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GVQASGSEGAAASSSAPKPSL RSSS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RLAGKVRMHW------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GPVFKKEWKKRQPSVDSKAVHPTTTVKKKVA KGVGQ------------------------------------------------------- ---------------------------------------------PTSMAFPQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCPIETGMMVWFKFQNHPFWPAV------ ------------------------------VKSVNHTERTARVLPVEADMHHD-QSGLRV PLRRLKHLECNAKEKLLKRARKVYEQSVDWCFSLISHYREELARGSFAGSFLDYYAADIS YPLRRAVQEGELYIAFPKVNYADL-E--DSEEESSPGG-RRPR--------KKILPDRMK AARDRDNQKLVDFIVKRKGAD--------------------------------------- ------------------------HHLLDIVKGRKQSRWLTSFLNSSRYVICVETYLEDE DQLDVVMQHLQEI-Y-KHIDKNKLSLTRDDKVSFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDGVDYKKAEEKYLRGPP------------------------- -------------------VHYR----EKELFDKNILKKIN---KRP------------- -------------------------------------------AIR-------------- ----------GRA-------------R--------------------------------- ----------------------------------------------- >ENSMLUP00000013067 ------------------------------------------------------M--DS- EYVLCNWKGHFWPARVLSRSETSPKS--KGKKICSLEVQILAVGKKVKVKNRDIKILDES RIESITSLL---GAQTTARVPPGEGEAYKSALAIALEILKDRANLGA-A----------- --------------------------RASDDPE--------------------------- --------------------------------------------------------TPMM ------------SQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------KGT-------------QKRSHKKFPKPKGN---------------------- ------------------------------------------------------------ --------SPRSLRKSK------------------------------------------- ---------------------------------------NPKS-LLVGSEGE-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEGDKSQVHTPLAPAPKRRR----------------------------------- ------------------------------------------------------------ ---------GRPPQSHSMCSNFPPLS-EE----ER------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ETEG----------------- -------------------------------QAKTGTS---------------------- -RVRSQH---------VTAKEEAAGAQEGS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---ILPS----------------------------QPPG--------------------- ------------------------------------------------------------ ------------------LSVTVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------RKRKAP------------------------ --------------------RSTC------------------------------P--KTL AVSSEGSP----------------------------------SSG-NIEDPEE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GVQASGSEGAAASSSAPKPSP RSSS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RLAGKVRKQW------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GPVFKKEWKKRQPSVDSKAVHPTTTVKKKVA KGVGQ------------------------------------------------------- ---------------------------------------------PTSMAFPQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCPIETGMMVWFKFQNHPFWPAV------ ------------------------------VKSVNHTERTARVLPVEADMHHD-QSGLQV PLRRLKHLECNAKEKLLKRARKVYEQSVDWCFSLISHYREELARGSFAGSFLDYYAADIS YPLRRAVQEGELYIAFPKVNYADL-E--DSEEESSPGG-RRPR--------KKILPDRMK AAWDRDNQKLVDFIVKRKGAD--------------------------------------- ------------------------HHLLDIVKGRKQSRWLTSFLNSSRYVICVETYLEDE DQLDVVMQHLQEI-Y-KHIDKNKLSLTRDDKVSFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDGVDYKKAEEKYLRGPP------------------------- -------------------VHYR----EKELFDKNILKKIS---KRP------------- -------------------------------------------AIE-------------- ----------G---------------W--------------------------------- ----------------------------------------------- >ENSCJAP00000072495 ------------------------------------------------------M--DS- EYVLCSWKGRLWPAKVLCTRATSPKT--MRQVAPSLEVQILAVDEKIKVSSTDVRTPTKS EMEDIAASA---AAQRMVGAPPGEKLGYRGTLQVALEMLNERTNLRG-G----------- --------------------------RKPHEQE--------------------------- --------------------------------------------------------STTP ------------SQPSQKVPEKPASS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------LPR------ ----EDDWRRTLD----------------------------------------------- -------FR--------------------------------------------------- ------------------------------------------------------------ ----------KSLEKRE------------------------------------------- ---------------------------------------NPRS-PTVPSES--TLHGDRS PARTPTALTPGALCGDSSGELTATAPTPGA------------------------------ ------------------------------------------LCGDSS------------ ----------------GELT---------------------------------------- ----ATAPTPGALCGDSSGELTAT------------------------------------ APTPGALCGDSSGELTATAPTPGALHGDGSQAHTAIAPTPGTKCSDSSTTCTATTPSPGA LHGDRSPTHVAIASNPGALHSDGSQARTAIAPTLGAPGSDSSTAGTAISPPPGALRGGMS DRSEKRKDVAPPPGT--------------------------------------------- ---------------------------LRVDKSPARRAIAPTPGALGGDSSPAPTGIAPT PGALGGDRSLVHMAVASTQGALQGGSSQTHTNIAPTPGA--------------------- ------------------------RHSDSSTPRMAVAPSPGALRGDRSRKHKAITPTPGT PRVDSSAARKAIAPT--------------------------------------------- ---------------------------LGALGSDGSPARMAIASTPGTLRGDRTDRSRKH ------------------------------------------------------------ ------------------------------------------------------------ ------KAIALTPGTLGSDSSPAPTGIAPSPGALHDDRSPGHVAIASTPGALQSDGFQVC TTIAPTPGAMHGDSSTACTATAPTPDALPSDRSDRSGKRKATAPTPGPLRTDSSPVPT-- --------------------------------GIAPSPGTLHGDRSPAHKAIASTPGALH SDNTDRSRKRKAIALTPGTLRVDGSPACRAIAPTPGALGSDSSPAHMNIARAPGALHGDS SPAHTAIASTPGAPHSDGSQAHTAVAPTPGTMRSDSAMVRMAIDPTRGTLRGD------- ------------------------------------------------------------ ---------------------------------------RSDRSQKPKAVAPTPGTLRGD RTDRSRKRKSIALTPGTLRVDRSPARRDIAPTPGTLGSDRSPAHTNTTPTPGPLGGDRSL AHMAIASTPGALQGDGSQVHTAIAPTPGAIRSDSSTMCMAIAPTPGALHGDRSRKHKAIA PTPGAPRTDRSQIHTAIAPTPGAQR----------------------------------- ------------------------------------------------------------ ---------V-----------------------DRSTACKAIAPIPGALGGDGSPARTAM APTPHALRGDRSRKRKAIAPTPGTLCGDSSPAGRAIAPTPGTLGGDGSP----------- -------------------------AHTAIAPTPGDMRGHSSPSCMAIGPISGTLRGDRS QKRK-------------------AFAPTPGALHSDRPQTHMAIAPIPGVLCSDSSPAHMA IDPTPGAMDSDSSTARTAIVPTPGALRGDRSRKRKAIAPTPGTPQGDRSEMHMAISPTAG TQHSDRSPAHRAFAPTPGALHCDSSGEGMAIGPTRCTAGTLHGEGSQAHKDIAPTPGALR GERSQTRMAIAPTPGGMQAQALQSCRAGQDSLTHSWRGCEIKG----------------- -------------------------------KKRAKAS---------------------- -TLTSLP---------PTVKGKGA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------S----------------------------RPPG--------------------- ------------------------------------------------------------ ------------------LTSPVP-PA--------------------------------- ------------------------------------------------------------ ------------------------------LKEDTL------------------------ ---------------------DSR------------------------------PKKKTL AASPECSP----------------------------------FSG-DIQDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GAWKPGWAGLAPSSGSPQHRL PSSP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIAERKRKLP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GPDFQRRPRRPQPPGDAKAANPVTAIQRAGR KQDGR------------------------------------------------------- ---------------------------------------------PAGLALRRE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRPIERGTLVWFKFQDHPFWPAV------ ------------------------------VKSVSNTDKTARVLLLDDNLHHG-NRGIQV PLQRLKHLDCKEQEKLLKRAQKAYKQSVDWCFSLISHYREGLVRGSFRGSFLDYYAADVS YPVRRAVQEGDLQIDFPKVNYADL-E--DWEEETSLGG-KRPC--------KKILPDRMR AARDRDNRKLVDFIVREKGAD--------------------------------------- ------------------------PHLLDILQGRKQSRWLTMFLTPHRDLLCFETYLEDD DQLEVVTKHLQEI-YNKQMDKTMLTRIRDDKVNFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAIAATDGLDYKAAEEKYLRGPP------------------------- -------------------VHYR----EKELFDRNVLKKRR---RKP------------- -------------------------------------------ATT-------------- ----------REA-------------N--------------------------------- ----------------------------------------------- >ENSCJAP00000077871 ------------------------------------------------------M--DS- EYVLCSWKGRLWPAKVLCTRATSPKT--MRQVAPSLEVQILAVDEKIKVSSTDVRTPTKS EMEDIAASA---AAQRMVGAPPGEKLGYRGTLQVALEMLNERTNLRG-G----------- --------------------------RKPHEQE--------------------------- --------------------------------------------------------STTP ------------SQPSQKVPEKPASS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------LPR------ ----EDDWRRTLD----------------------------------------------- -------FR--------------------------------------------------- ------------------------------------------------------------ ----------KSLEKRE------------------------------------------- ---------------------------------------NPRS-PTVPSES--TLHGDRS PARTPTALTPGALCGDSSGELTATAPTPGA------------------------------ ------------------------------------------LCGDSS------------ ----------------GELT---------------------------------------- ----ATAPTPGALCGDSSGELTAT------------------------------------ APTPGALCGDSSGELTATAPTPGALHGDGSQAHTAIAPTPGTKCSDSSTTCTATTPSPGA LHGDRSPTHVAIASNPGALHSDGSQARTAIAPTLGAPGSDSSTAGTAISPPPGALRGGMS DRSEKRKDVAPPPGT--------------------------------------------- ---------------------------LRVDKSPARRAIAPTPGALGGDSSPAPTGIAPT PGALGGDRSLVHMAVASTQGALQGGSSQTHTNIAPTPGA--------------------- ------------------------RHSDSSTPRMAVAPSPGALRGDRSRKHKAITPTPGT PRVDSSAARKAIAPT--------------------------------------------- ---------------------------LGALGSDGSPARMAIASTPGTLRGDRTDRSRKH ------------------------------------------------------------ ------------------------------------------------------------ ------KAIALTPGTLGSDSSPAPTGIAPSPGALHDDRSPGHVAIASTPGALQSDGFQVC TTIAPTPGAMHGDSSTACTATAPTPDALPSDRSDRSGKRKATAPTPGPLRTDSSPVPT-- --------------------------------GIAPSPGTLHGDRSPAHKAIASTPGALH SDNTDRSRKRKAIALTPGTLRVDGSPACRAIAPTPGALGSDSSPAHMNIARAPGALHGDS SPAHTAIASTPGAPHSDGSQAHTAVAPTPGTMRSDSAMVHMAIDPTRGTLRGD------- ------------------------------------------------------------ ---------------------------------------RSDRSQKPKAVAPTPGTLRGD RTDRSRKRKSIALTPGTLRVDRSPARRDIAPTPGTLGSDRSPAHTNTTPTPGPLGGDRSL AHMAIASTPGALQGDGSQVHTAIAPTPGAIRSDSSTMCMAIAPTPGALHGDRSRKHKAIA PTPGAPRTDRSQIHTAIAPTPGAQR----------------------------------- ------------------------------------------------------------ ---------V-----------------------DRSTACKAIAPIPGALGGDGSPARTAM APTPHALRGDRSRKRKAIAPTPGTLCGDSSPAGRAIAPTPGTLGGDGSP----------- -------------------------AHTAIAPTPGDMRGHSSPSCMAIGPISGTLRGDRS QKRK-------------------AFAPTPGALHSDRPQTHMAIAPIPGVLCSDSSPAHMA IDPTPGAMDSDSSTARTAIVPTPGALRGDRSRKRKAIAPTPGTPQGDRSEMHMAISPTAG TQHSDRSPAHRAFAPTPGALHCDSSGEGMAIGPTRCTAGTLHGEGSQAHKDIAPTPGALR GERSQTRMAIAPTPGGMQAQALQSCRAGQDSLTHSWRGCEIKG----------------- -------------------------------KKRAKAS---------------------- -TLTSLP---------PTVKGKGA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------S----------------------------RPPG--------------------- ------------------------------------------------------------ ------------------LTSPVP-PA--------------------------------- ------------------------------------------------------------ ------------------------------LKEDTL------------------------ ---------------------DSR------------------------------PKKKTL AASPECSP----------------------------------FSG-DIQDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GAWKPGWAGLAPSSGSPQHRL PSSP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RIAERKRKLP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GPDFQRRPRRPQPPGDAKAANPVTAIQRAGR KQDGR------------------------------------------------------- ---------------------------------------------PAGLALRRE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRPIERGTLVWFKFQDHPFWPAV------ ------------------------------VKSVSNTDKTARVLLLDDNLHHG-NRGIQV PLQRLKHLDCKEQEKLLKRAQKAYKQSVDWCFSLISHYREGLVRGSFRGSFLDYYAADVS YPVRRAVQEGDLQIDFPKVNYADL-E--DWEEETSLGG-KRPC--------KKILPDRMR AARDRDNRKLVDFIVREKGAD--------------------------------------- ------------------------PHLLDILQGRKQSRWLTMFLTPHRDLLCFETYLEDD DQLEVVTKHLQEI-YNKQMDKTMLTRIRDDKVNFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAIAATDGLDYKAAEEKYLRGPP------------------------- -------------------VHYR----EKELFDRNVLKKRR---RKP------------- -------------------------------------------ATT-------------- ----------REA-------------N--------------------------------- ----------------------------------------------- >ENSP00000498408 ------------------------------------------------------M--DS- EYVLCSWKGRLWPAKVLCTRGTSPKT--KPEKAISLEVQILAVDEKIKVKSTDVKTPTKF EMEDIAASA---AAQTKLGAPLREKMGYRGTLRVALEILKERTNLGG-G----------- --------------------------RKPHELE--------------------------- --------------------------------------------------------STTP ------------SQLSQKVPEKPASS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------VPR------ ----EDDWRCKGD----------------------------------------------- -------LR--------------------------------------------------- ------------------------------------------------------------ ----------RSLGKRE------------------------------------------- ---------------------------------------NPSS-PTVPSESKRALRDDRS QEPTAIAPTPGALPGDRSGAPRAIAPTPGAMLSGRSRARRAIAPTPSALRGYRSWAHRAI APTPGCLYSDRSRAHRAIAPARGTKHGGRSWACRSIAPKPGSLCGDRSQASRAIDPTLGA RRGGRSRAHRAIAPTPGSLCGNRSRACGAIALTPGVLCGVRSRVPKDITPTPGALRGYKS WVCRAIAPTPGALRGDRSAARTAVVRTPGALGRDRSRARSAIASTPGTLQGNRSSVSKAI APTPGALRGDRSAARTAFVPTPGALHRDRSRARSAIASTPGTLRGNTSSACKAIAPTPGA LRGYKSWARRAIAPNPGAWRGYRSTTGTAIAPNLGALGGNRSAARTDIAPTPGALRG--- YRSWTRRAIAPTPGTLSSYRSRSRRTIASTPATLRGEKSRAHTSLAPTPGALRGDGSRAR RAIVPTTCPLCEIWSRVGIGIAPIADALRRDRSPVRRAIAPTPGTLSGYRSRARTAIAPT PGTLRGYRPRSRRAIASTPATLRGEKSRAHTSLAPAPGALRGDGSRARRAIVPTTCPLCE IWSRVGIGIAPIADALRRDRPPVRR---------AIAPTPGALRCDRSRELTAIDPTPGA LCSDRSGASRAIAPTPGTLCSERSRVRRAIAPTPCALCGKGSQVGMGVAPTPGALRRDRS QAGRAIAPTPSALFRVGSRVGTGIALPAGALHRDRSPVRRAVAPTPGTL----------H CDGSRKCTATGSTPGALPGDRSGVSKATAPAPGALCSERSRARRSIAPTPCLLCGDRSWV GMGIAPTPGALLGGKS-----------RKCRAIAITPGALRGGRSQKRRVVAPTPEALHG DGSWTYMAIAPTPGALHGDSSPAHTSIIPSPGALHGDGPPAHMAFPSTPGTLHGDASHAH MAIAPTPGTMRGDSSTARTAT--------------------------------------- ----------------------------------APSPGALRGDRSWKRKAIASTPGALH GNRSDRSRKCKAIASTPGTLHVERSPALRAIVPTPGTLGRDSSPGRTSIIPSPGALHGDR SPAHLDIASTPGALHGDSSQAHTAIAPTPGTMRGDSSTARMAIAPSAGALRGDRS----- --------------------------------------W--------------------- ------------------------KRKAIASTPGALRGNRSDRSRKRKAIASTPGALLGN RSDRSRKHKAIAPTPGAPRIDRSPACRAIAPTPGALGDDSS---TAIAPTPGTPRGDSSP ANTAIASTPGALHGDTSQTHKAIAPTPGDLGGGSSSAHKAITPSPGALHGDRSPAHTAIA STPGALHGDSSQVHTTIAPTPG-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----ALRDDKSWKRKAIAPTPGTLHCDSSRTCTAFAPTPGALHADRSPAHQDITLTSGA LHCDSSRESRAVAPILGALHRVGSQAHKAIASTPGPLRGDSSPFHTAIAPMPGALHGTRS WKREAISQTPFVTLCGDSSGERMAIAPTPGALHSDRSQTHTAIDPTPSVLRSDSSPACMA IDPTPGALGRD------------------------------------------------- ------------------------------------------------------------ --RSQALMAIAPTPVGMQAHVLQSPRACQDSLTLSRHVCEKKG----------------- -------------------------------KKRANAS---------------------- -TLMSLP---------PTVTEEGA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------S----------------------------LPPG--------------------- ------------------------------------------------------------ ------------------LTSPAP-PA--------------------------------- ------------------------------------------------------------ ------------------------------LKEETQ------------------------ ---------------------DSR------------------------------P-KKAL AASPESSP----------------------------------FSG-NIQDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GAWKPGWAGMAASSGSRQHRL PSSL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RLANRKRKRP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GPDFQRRPQGPQTPGDAKLANPVTTIQRAGG KQDGQ------------------------------------------------------- ---------------------------------------------PPSLAFPQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PHPIERGTMVWFKFQDHPFWPAV------ ------------------------------VKSVSNTDKTARVLLLEANLHHG-KRGIQV PLRRLKHLDCKEKEKLLKRAQKAYKQSVNWCFSLISHYREGLVRGSFRGSFLDYYAADIS YPIRRAIQEGDLQIDFPKVNYGDL-E--DWEEETSLGG-KRPC--------KKILPDRMR ASWDRDNQKLVDFIVRRKGAD--------------------------------------- ------------------------PHLLDILQGRKQSRWLTAFLKPHRDLHCIETYLEDD DQLEVVAKHLQEI-Y-KQIDKARLTLIRDDKVNFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------MICTIAALDGLDYKAAEEKYLRGPP------------------------- -------------------VHYR----EKELFDRNILKKAR---REP------------- -------------------------------------------ATT-------------- ----------HTA-------------N--------------------------------- ----------------------------------------------- >ENSLAFP00000025198 I-----------------------------------------------------M--DG- EYVLCNWKGRLWPAKVLSRSGTSPKS--KREVARHLEVQILSLDEKIKVKSKQIQMLTES QMEAMASSW---VARSKFRAPTGEERAHRKALNVALEILEERARLGH-S----------- --------------------------SAFHKEE--------------------------- --------------------------------------------------------TNSL ------------SQ---RVPQETSRA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------LPP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------RKFGKR-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------TGEGSRSH------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------GKNIEFSKFPVVSLVRC------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ALCGDEPQKHAAPGPVLSETE----------------------------------- ------------------------------------------------------------ ---------PKSSPSSRVGHRFPSLS-EG----GD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEG----------------- -------------------------------KKKADTS---------------------- -AVMSSH---------PTVVTEGA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------CAKHQEGIP------------VWPSG--------- ------------------------------------------------------------ ---------------------TLRTGLKALVKAEVQ------------------------ ---------------------DAC------------------------------P--KTR ARSRGSSA----------------------------------FSE-NTEGPRE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSKPSSAGAATRSSSSNL-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------RLTNRKRKLQIQGAQ------------------------- ----NGLKKRPP-----------------V------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------DDSEAT-----GPVKSKSRHGP----------------------------- -RQGQ------------------------------------------------------- ---------------------------------------------SRCVARPQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCPTERGMVVWFKFQDYPYWPAV------ ------------------------------VVSVQSVEKTARVLLIEAYMSQE-RRGIRV PLRRLKPLDCEQKPKLMNRARKLYGQSVDWCCSLVAHYREAVGHRSFVGSFLEYFAADIS YPIRKAVQEGEVDSDFPRVNYNDL-E--ESEEEPHLGG-KGRY--------KKLLPDRMK AARDRGNQKLLDFIVKRKGAE--------------------------------------- ------------------------RHLLDIVDGRKQSTWLDSFLGSARRMACIETYLEDE DQLDVLVRYLQEI-Y-EQIDQRMLTRIKNDKVNFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISALEGLDYKDAEAKYLNGPP------------------------- -------------------VHYR----EKELFDRKALVERR---RRL------------- -------------------------------------------V---------------- ------------------------------------------------------------ ----------------------------------------------- >ENSCHIP00000003017 ------------------------------------------------------M--DA- EYVLCNWQDQLWPAKVLSRSEASSDS--KRKKVFFLEVQILSLDEKIQMESTETKILTKS QVEAIASSL---ATQSEVGDPPGEETAYARSLKMALDILNARTNLIQ-V----------- --------------------------SSSDEEE--------------------------- --------------------------------------------------------TTIL ------------SQ---NIPQKPSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KKYRKHEGEG--------------------- ------------------------------------------------------------ -------DLPKCLEENE------------------------------------------- ---------------------------------------NSTT-LLVSSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLYDDKSQVHAVIDSIPNEME----------------------------------- ------------------------------------------------------------ ---------TKSSQNLSWCQTFPSLS-ED----ED------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KKKIDLS---------------------- --ILPLL---------STIKEEDVYVKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FSS-----------------------------TLPS--------------------- ------------------------------------------------------------ ------------------DGFIVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEDPE------------------------ ---------------------DIY------------------------------P--EAP ATSSECFA----------------------------------LSE-NIDDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------DPCSVANQNQPTVESE MGAEA------------------------------------------------SPQPSSR E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----HQVSFSASSHSGDYS-LLGSNERNFQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------EFE--E-EFQ----A------- -----------------------------------------------SDKSARASSIAAS IL-------DDD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFLFHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QRSFETGMIVWFKYQKYPFWPSV------ ------------------------------IKSIRRKERKASVIFVEANMNPE-KRGVRV PFRRLKKFDCKEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFFEYYAADIS YPVRKIIKQDTFRNLFPKLQNENT-G--RSMSVISQTK-KMSF--------QKILPDRMK SARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------SHLLAILNGTKGSRWLKSFLNAHRFTPCIETYFEDE DQLDEVVKYLQEV-Y-KQIDEKMLTRIRDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYQAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDSKILFEKR---RKP------------- -------------------------------------------LTK-------------- -----------ED----------------------------------------------- --H-------------------------------------------- >ENSBMUP00000026600 ------------------------------------------------------M--DA- EYVLCNWQDQLWPAKVLSRSEASSNS--KRKKVFSLEVQILSLDEKIQMESTETKILTKS QVEAIASSL---ATQSEVSDPPGEETAYARSLKMALDILNERTNLIQ-V----------- --------------------------SSSDEEE--------------------------- --------------------------------------------------------TTIL ------------SQ---NIPQKPSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KKYRKHEGEG--------------------- ------------------------------------------------------------ -------DLPKCLEENE------------------------------------------- ---------------------------------------NSTI-LLVSSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLDDDKSQVHAMIDNIPNETE----------------------------------- ------------------------------------------------------------ ---------TKSSQNLSWCQTFPSLL-ED----ED------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KKKIDLS---------------------- --ILPLL---------STIKEEDVYVKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FSP-----------------------------TLPS--------------------- ------------------------------------------------------------ ------------------DGFIVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEPE------------------------ ---------------------DIY------------------------------P--EAL AASSECSA----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------DPCSVASQNQPTVESE MDAEA------------------------------------------------FPQPSSQ E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----QQVSFSASSHSGDYS-LLGSNERNLQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------EFE--E-EFQ----A------- -----------------------------------------------SDKSARISSIAAS IL-------DDD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFLFNYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QRSFETGMIVWFKYQKYPFWPSV------ ------------------------------IKSIRRKERKASVVFVEANMNPE-KRGVRV PFRRLKKFDCKEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFFEYYAADIS YPVRKIIKQDTFRNLFPKLQNENT-G--GSMSVTSQTK-KMSF--------QKLLPDRMK SARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------SHLLAILNGTKGSRWLKSFLNAHRFTPCIETYFEDE DQLDEVVKYLQEV-Y-KQIDEKMLTRIRNDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGYR------------------------------------- ------------------------------------------------------------ ------------DFFLENYLIQKSCLKR---GG--------------------------- -NH-------------------------------------------- >ENSBIXP00005012855 ------------------------------------------------------M--DA- EYVLCNWQDQLWPAKVLSRSEASSNS--KRKKVFSLEVQILSLDEKIQMESTETKILTKS QVEAIASSL---ATQSEVSDPPGEETAYARSLKMALDILNERTNLIQ-V----------- --------------------------SSSDEEE--------------------------- --------------------------------------------------------TTIL ------------SQ---NIPQKPSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KKYRKHEGEG--------------------- ------------------------------------------------------------ -------DLPKCLEENE------------------------------------------- ---------------------------------------NSTI-LLVSSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLDDDKSQVHAMIDNIPNETE----------------------------------- ------------------------------------------------------------ ---------TKSSQNLSWCQTFPSLL-ED----ED------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KKKIDLS---------------------- --ILPLL---------STIKEEDVYVKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FSP-----------------------------TLPS--------------------- ------------------------------------------------------------ ------------------DGFIVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEPE------------------------ ---------------------DIY------------------------------P--EAL AASSECSA----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------DPCSVASQNQPTVESE MDAEA------------------------------------------------FPQPSSQ E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----QQVSFSASSHSGDYS-LLGSNERNLQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------EFE--E-EFQ----A------- -----------------------------------------------SDKSARISSIAAS IL-------DDD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFLFNYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QRSFETGMIVWFKYQKYPFWPSV------ ------------------------------IKSIRRKERKASVVFVEANMNPE-KRGVRV PFRRLKKFDCKEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFFEYYAADIS YPVRKIIKQDTFRNLFPKLQNENT-G--GSMSVTSQTK-KMSF--------QKLLPDRMK SARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------SHLLAILNGTKGSRWLKSFLNAHRFTPCIETYFEDE DQLDEVVKYLQEV-Y-KQIDEKMLTRIRNDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDSKILFEKR---RKP------------- -------------------------------------------LTK-------------- -----------ED----------------------------------------------- --H-------------------------------------------- >ENSBTAP00000048597 ------------------------------------------------------M--DA- EYVLCNWQDQLWPAKVLSRSEASSNS--KRKKVFSLEVQILSLDEKIQMESTETKILTKS QVEAIASSL---ATQSEVSDPPGEETAYARSLKMALDILNERTNLIQ-V----------- --------------------------SSSDEEE--------------------------- --------------------------------------------------------TTIL ------------SQ---NIPQKPSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KKYRKHEGEG--------------------- ------------------------------------------------------------ -------DLPKCLEENE------------------------------------------- ---------------------------------------NSTI-LLVSSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLDDDKSQVHAMIDNIPNETE----------------------------------- ------------------------------------------------------------ ---------TKSSQNLSWCQTFPSLL-ED----ED------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KKKIDLS---------------------- --ILPLL---------STIKEEDVYVKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FSP-----------------------------TLPS--------------------- ------------------------------------------------------------ ------------------DGFIVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEPE------------------------ ---------------------DIY------------------------------P--EAL AASSECSA----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------DPCSVASQNQPTVESE MDAEA------------------------------------------------FPQPSSQ E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----QQVSFSASSHSGDYS-LLGSNERNLQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------EFE--E-EFQ----A------- -----------------------------------------------SDKSARISSIAAS IL-------DDD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFLFNYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QRSFETGMIVWFKYQKYPFWPSV------ ------------------------------IKSIRRKERKASVVFVEANMNPE-KRGVRV PFRRLKKFDCKEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFFEYYAADIS YPVRKIIKQDTFRNLFPKLQNENT-G--GSMSVTSQTK-KMSF--------QKLLPDRMK SARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------SHLLAILNGTKGSRWLKSFLNAHRFTPCIETYFEDE DQLDEVVKYLQEV-Y-KQIDEKMLTRIRNDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDSKILFEKR---RKP------------- -------------------------------------------LTK-------------- -----------ED----------------------------------------------- --H-------------------------------------------- >ENSBBBP00000028086 ------------------------------------------------------M--DA- EYVLCNWQDQLWPAKVLSRSEASSNS--KRKKVFSLEVQILSLDEKIQMESTETKILTKS QVEAIASSL---ATQSEVSDPPGEETAYARSLKMALDILNERTNLIQ-V----------- --------------------------SSSDEEE--------------------------- --------------------------------------------------------TTIL ------------SQ---NIPQKPSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KKYRKHEGEG--------------------- ------------------------------------------------------------ -------DLPKCLEENE------------------------------------------- ---------------------------------------NSTI-LLVSSDSD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLDDDKSQVHAMIDNIPNETE----------------------------------- ------------------------------------------------------------ ---------TKSSQNLSWCQTFPSLL-ED----ED------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KKKIDLS---------------------- --ILPLL---------STIKEEDVYVKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FSP-----------------------------TLPS--------------------- ------------------------------------------------------------ ------------------DGFIVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEPE------------------------ ---------------------DIY------------------------------P--EAL AASSECSA----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------DPCSVASQNQPTVESE MDAEA------------------------------------------------FPQPSSQ E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----QQVSFSASSHSGDYS-LLGSNERNLQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------EFE--E-EFQ----A------- -----------------------------------------------SDKSARISSIAAS IL-------DDD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFLFNYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QRSFETGMIVWFKYQKYPFWPSV------ ------------------------------IKSIRRKERKASVVFVEANMNPE-KRGVRV PFRRLKKFDCKEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFFEYYAADIS YPVRKIIKQDTFRNLFPKLQNENT-G--GSMSVTSQTK-KMSF--------QKLLPDRMK SARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------SHLLAILNGTKGSRWLKSFLNAHRFTPCIETYFEDE DQLDEVVKYLQEV-Y-KQIDEKMLTRIRNDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDSKILFEKR---RKP------------- -------------------------------------------LTK-------------- -----------ED----------------------------------------------- --H-------------------------------------------- >ENSAMEP00000019688 ------------------------------------------------------M--DA- EYVLCNWKDRLWPAKVLSRSEMSSDS--KRKKTFSLEVQILSLDEKINVESTETKILNKS QIEAIASSL---AAQSEVSDPPRRETAYERSLKVALDILNERTNLSQ-A----------- --------------------------SSSDEEG--------------------------- --------------------------------------------------------TTTL ------------SQ---DDPQKLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------RPR------ ------------------------------------------------------------ -----------------------------KKYRKHEGDE--------------------- ------------------------------------------------------------ ------GDLSKCLEESE------------------------------------------- ---------------------------------------NATSLLVANLENN-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLCDDKSQVRATIDSLTSEME----------------------------------- ------------------------------------------------------------ ---------TKSSENSGWYETFPSLS-ED----ED------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KKKIDIS---------------------- -AVMPLY---------STIKEEDVCVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FTP-----------------------------TWPS--------------------- ------------------------------------------------------------ ------------------DTFIVP-KV--------------------------------- ------------------------------------------------------------ ------------------------------EKEEAK------------------------ ---------------------DIC------------------------------P--ETL AVSSECPT----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCSSTSQNQP-VESE AGAAA------------------------------------------------SPRRCSW E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSHSASNRVLDYSLLLMNNETNLQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELG--E-ELQ----A------- -----------------------------------------------SDKSAQLNPIDTS IL-------DDN------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFVFNYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPAV------ ------------------------------VKSIRRKERKASVIFVEVSMNPE-KRGIRV PFRRLKKFDCKEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFLEYYAADIS YPLRKVIKQDTFRNLFPKLHNENS-G--EQMAVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------NHLLAILKGTKGSRWLKSFLNANRFSPCIETYFEDE DQLDEVVKYLQEV-Y-KQIDEKMLTLIRDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDAKILFEKR---RKP------------- -------------------------------------------LTN-------------- -----------EA----------------------------------------------- --Q-------------------------------------------- >ENSUAMP00000013072 ------------------------------------------------------M--DA- EYVLCNWKDQLWPAKVLSRSEMSSDS--KRKKTFSLEVQILSLDEKINVESTETKILNKS QIETIASSL---AAQSEVSDPPRKETAYERSLKVALDILNERTNLSQ-A----------- --------------------------SNSDEEA--------------------------- --------------------------------------------------------TTTL ------------SQ---NDPQKLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KKYRKHEGDG--------------------- ------------------------------------------------------------ ------DDLSKCLEESE------------------------------------------- ---------------------------------------NATSLLVANLGNN-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLCDDKSQVRATIDNLTSEME----------------------------------- ------------------------------------------------------------ ---------TKSSENSGWYETFPSLS-ED----ED------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KKKIDIS---------------------- -AVMPLY---------STIKEEDVCVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FTP-----------------------------TWPS--------------------- ------------------------------------------------------------ ------------------DTFIVP-KV--------------------------------- ------------------------------------------------------------ ------------------------------EKEEAK------------------------ ---------------------DIG------------------------------P--ETL AVSSECPT----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCSSTSQNQP-VESE AGAAA------------------------------------------------SPRRCSW E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSRSASNRVLDYSLLLMNNETNLQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELG--E-ELQ----A------- -----------------------------------------------SDKSAQLNPIDTS IL-------DDN------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFVFNYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPAV------ ------------------------------VKSIRRKERKASVLFVEVSMNPE-KRGIRV PFRRLKKFDCKEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFLEYYAADIS YPLRKVIKQDTFRNLFPKLHNENS-G--EQMVVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------NHLLAILKGTKGSRWLKSFLNANRFSPCIETYFEDE DQLDEVVKYLQEV-Y-KQIDEKMLTLIRDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDAKILFEKR---RKP------------- -------------------------------------------LTN-------------- -----------EA----------------------------------------------- --Q-------------------------------------------- >ENSNVIP00000018254 ------------------------------------------------------M--DA- EYVLCNWKDQLWPAKVLSRSEMSSNS--KRKKTFSLEVQILSLDEKIKVESTETKILNKS QIEALASSL---EAQSEVSSPPREETAYERSLKVALDILNEKTDLSQ-A----------- --------------------------SSSDEES--------------------------- --------------------------------------------------------TSTL ------------SQ---NDPQNLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PSR------ ------------------------------------------------------------ -----------------------------KKYRRHEGDG--------------------- ------------------------------------------------------------ -------DLSKCLEESE------------------------------------------- ---------------------------------------NATSLSVANLENN-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLCDDKSRVHATIDTLASEME----------------------------------- ------------------------------------------------------------ ---------TKSSENSSWYETFPSLS-ED----ED------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KKKIDIL---------------------- -AVMPLY---------STIKEEDICVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FTP-----------------------------TWSS--------------------- ------------------------------------------------------------ ------------------DTFIVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------VKEEAQ------------------------ ---------------------DIC------------------------------P--ETL AVSSECST----------------------------------FSE-NTEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCSSTSQNQP-VESE AGAAA------------------------------------------------SPRHCSW E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSLSASNRVLDYSLLLSNNEGNLQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELG--E-ELQ----A------- -----------------------------------------------SDKSAQLNPIDAS IL-------DDN------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFVFNYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPAV------ ------------------------------VKSIRRKERKASVLFVEASMNPE-KRGIRV PFRRLKKFDCKEKQALVDKAREEYSESIDWCISLICDYRVRLGCGSFAGSFLEYYAADIS YPLRKVIKQDTFRNLFPKLHNENS-A--EQMVVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------NHLLAILKGTKGSRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDEKMLTLIRDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDAKILFEKR---RKP------------- -------------------------------------------LTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSMPUP00000018742 ------------------------------------------------------M--DA- EYVLCNWKDQLWPAKVLSRSEMSSNS--KRKKTFSLEVQILSLDEKIKVESTETKILNKS QIEALVSSL---EAQSEVSSPPREETAYERSLKAALDILNEKTDLSQ-A----------- --------------------------SSSDEEA--------------------------- --------------------------------------------------------TSTL ------------SQ---NDLQNLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KKYRKHEGDG--------------------- ------------------------------------------------------------ -------DLSKCLEESE------------------------------------------- ---------------------------------------NATSLSVANLENN-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLCDDKSRVHATIDTLASEME----------------------------------- ------------------------------------------------------------ ---------TKSSENSSWYETFPSLS-ED----ED------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KKKIDIL---------------------- -AVMPLY---------STIKEEDVCVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FTP-----------------------------TWSS--------------------- ------------------------------------------------------------ ------------------DTFIVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------VKEEAQ------------------------ ---------------------DIC------------------------------P--ETL AVSSECST----------------------------------FSE-NTEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCSSTSQNQP-VESE AGAAA------------------------------------------------SPRHCSW E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSLSASNRVLDYSLLLRNNEGNLQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELG--E-ELQ----A------- -----------------------------------------------SDKSAQLNPIDAS IL-------DDN------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFVFNYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPAV------ ------------------------------VKSIRRKERKASVLFVEASMNPE-KRGIRV PFRRLKKFDCKEKQALVDKAREEYSESIDWCISLICDYRVRLGCGSFAGSFLEYYAADIS YPLRKVIKQDTFRNLFPKLHNENS-A--EQMVVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------NHLLAILKGKKGSRWLKSFLNSNRFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDEKMLTLIRDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGCR----ERELFDSKILFEKR---RKP------------- -------------------------------------------LTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSPPRP00000020305 ------------------------------------------------------M--DA- EYVLCNWKDQLWPAKVLSRYETSLNS--KRKKTFSLEVQILSLDEKIKVESTETKILNKS QIEAIASSL---AAQSEVSTPPREETAYERSLKVALDILNERIYLSQ-A----------- --------------------------SSSYDKA--------------------------- --------------------------------------------------------TTTL ------------SQ---NDPQKLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKYRKHEG----------------------- ------------------------------------------------------------ -------DLSECLEESE------------------------------------------- ---------------------------------------NATS-SLVSLENN-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLYDDKSQVHATIDTLPSEME----------------------------------- ------------------------------------------------------------ ---------TKSSENSSWCQRFPSLS-ED----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KKKIDIS---------------------- -TVMPLH---------STIKEEDVCVKNEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FTP-----------------------------TLPL--------------------- ------------------------------------------------------------ ------------------DTLTVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEAQ------------------------ ---------------------DIC------------------------------P--ETQ AISSECSS----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCSDTSQNQP-VESE ASAVT------------------------------------------------SPRHCSW E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSFSASNNVLDYSLLLVNNERNPQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELG--E-DLQ----A------- -----------------------------------------------SDKSVNLNPIDTS IV-------DKN------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFVFNYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPAV------ ------------------------------VKSIRRKERKASVLFVEANMNPE-KRGIRV PFRKLKKFDCKEKQALVDKAREEYSESIDWCISLICDYRVRLGCGSFAGSFLEYYAADIS YPIRKVIKQDTFRNLFPKLHNENP-V--EQMVVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------NHLLAILKGTKGSRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEV-Y-KQIDERMLTLIRDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDAKILFEKR---RKP------------- -------------------------------------------LTN-------------- -----------ES----------------------------------------------- --H-------------------------------------------- >ENSCAFP00020008536 ------------------------------------------------------M--EA- EYVLCNWKDQLWPAKVLSRSEISSNN--KRKKTFSLEVQILSLDEKIKVESTEAKILSKS QIEALASSL---AAQSEGSDLPIEETAYERSLKVALDILNERTNVSQ-A----------- --------------------------SSSDEEA--------------------------- --------------------------------------------------------TTTL ------------SQ---NDPQKLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SPR------ ------------------------------------------------------------ -----------------------------KKYRKHEGDE--------------------- ------------------------------------------------------------ ------GDLLKCPEESE------------------------------------------- ---------------------------------------NAASLLVANLENN-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SQYDDKSQVHATIDALPSEME----------------------------------- ------------------------------------------------------------ ---------TKLSENPNWCETFPSLS-ED----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KKKIDIS---------------------- -TIMPLH---------STIKEEDAYIKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FTP-----------------------------TLLS--------------------- ------------------------------------------------------------ ------------------DTFTVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------VKEETP------------------------ ---------------------DVC------------------------------P--ETM AVSTESST----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCSDTSQNQP-VESE AGTSA------------------------------------------------SSQPCSQ E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSFSASNHALDYS-LLVNNERSLQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELG--E-ELQ----A------- -----------------------------------------------SDKSAQVNSL-SS IL-------DDN------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFVFNYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPAV------ ------------------------------VKSIRRKERKASVLFVEASMNPE-KRGIRV PFRRLKKFDCKEKQALVEKAREDYSESIDWCISLICDYRVRLGCGSFSGSFLEYYAADIS YPIRKVIKQDTFRNLFPKLQNENP-A--EQMVVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------NHLLAILKGTKASRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDEKMLTLIRDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDAKILFEKR---RKP------------- -------------------------------------------LTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSVVUP00000013010 ------------------------------------------------------M--EA- EYVLCNWKDQLWPAKVLSRSEISSNS--KRKKTFSLEVQILSLDEKIKVESTETKILSKS QIEALASSL---AAQSEGSDLPIEETAYERSLKVALDILNERTNVSQ-A----------- --------------------------SSSDEEA--------------------------- --------------------------------------------------------TTTL ------------SQ---NDPQKLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KKYRKHEGDE--------------------- ------------------------------------------------------------ ------EDLLKCPEESE------------------------------------------- ---------------------------------------NAASLLVANSENN-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SQYDDKSQVHATIDALPSEME----------------------------------- ------------------------------------------------------------ ---------TKLSENPNWCETFPSLS-ED----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KKKIDIS---------------------- -TIMPLH---------STIKEEDAYIKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FTP-----------------------------TLLS--------------------- ------------------------------------------------------------ ------------------DTFTVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------VKEETP------------------------ ---------------------DVC------------------------------P--ETM AVSTESST----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCSDTSQNQP-VESE AGTSA------------------------------------------------SSQPCSQ E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSFSASNHALDYS-LLVNNERSLQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELG--E-ELQ----A------- -----------------------------------------------SDKSAQVNSL-SS IL-------DDN------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFVFNYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPAV------ ------------------------------VKSIRRKERKASVLFVEASMNPE-KRGIRV PFRRLKKFDCKEKQALVEKAREDYSESIDWCISLICDYRVRLGCGSFSGSFLEYYAADIS YPIRKVIKQNTFRNLFPKLQNENP-A--EQMVVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------NHLLAILKGTKASRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDEKMLTLIRDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDAKILFEKR---RKP------------- -------------------------------------------LTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSSSCP00000070456 ------------------------------------------------------M--EA- EYVLCNWQDQLWPAKVLSRSEASSNS--KRKKTFSLEVQILLLDEKIKVESTETKILNKS QVEAIVSSL---AAESEASDPPREETAYGRALKAALDILNERTNLIQ-A----------- --------------------------SSSDEEE--------------------------- --------------------------------------------------------NPTL ------------SQ---NALQKLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKYRKHEGD---------------------- ------------------------------------------------------------ --------LPKCLEENE------------------------------------------- ---------------------------------------NPPS-LLVSSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLSDDKSQVRAIIDAIPSEME----------------------------------- ------------------------------------------------------------ ---------TKSSQDFSWCQTFPSLS-ED----EE------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KKKIDIS---------------------- -AVMPLH---------STIKEEDVCVKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FSP-----------------------------PLPL--------------------- ------------------------------------------------------------ ------------------DYFTVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEAE------------------------ ---------------------DIC------------------------------P--EAP AISSECST----------------------------------FTE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCSGTSQNQPTVESE TGACA--------------------------------------------------RPSSW E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSLSASSRAMDYSLLLGNNERNLQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------DLG--E-ERQ----A------- -----------------------------------------------SDKSVHVSSIDAS IL-------DDN------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFLFHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPAV------ ------------------------------VKSIRRKERKASVLFVEANMNPE-KRGIRV PFRRLKKFDCKEKQALVDQAREEYSESIDWCISLICDYRVRIGCGSFAGSFLEYYAADIS YPLRKVIKQDTFRNLFPKLQNENP-T--ESMVVTSQTK-KMSF--------QKILPDRMK SARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------SHLLAILKGTKGSRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDEKMLTLIRDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDAKIIFEKR---RKP------------- -------------------------------------------LTN-------------- -----------EA----------------------------------------------- --R-------------------------------------------- >ENSTTRP00000011041 ------------------------------------------------------M--DA- KYVLCNWQGQLWPAKVLSRSAASSNS--KRKKTFSLEVQILSLDKTIKVESTETKILSKS QVEAIAFSL---AAQSEVSDPPREETAYARSLKMALDILNERTNLIQ-A----------- --------------------------SSSDEGE--------------------------- --------------------------------------------------------TTTL ------------SQ---NVPQKLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KMYRKHEGD---------------------- ------------------------------------------------------------ --------LPKCLEENE------------------------------------------- ---------------------------------------NSTS-LLVSSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLYDDKSRVHAVIDTIPSEME----------------------------------- ------------------------------------------------------------ ---------TKSSQNFSWRHTFPSLS-ED----ED------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEI----------------- -------------------------------KKKIDIS---------------------- -TIMPLH---------STIKEEDVYVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FTP-----------------------------TLQS--------------------- ------------------------------------------------------------ ------------------DSFTVP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEAQ------------------------ ---------------------DIC------------------------------P--EAP AISSECST----------------------------------FSE-NSEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCSDTSQNQPTVESE MGVVA------------------------------------------------SPRPSSW E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----HQVSFSASNHAMDYSLLV-NNERNLQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELG--E-ELQ----A------- -----------------------------------------------SDKSVHLNSIDAS IL-------DDN------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFIFHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPAV------ ------------------------------VKSIRRKERKASVLFVEANMNPE-KRGIRV PFRRLKKFDCKEKQALVDKAREDYSESIDWCISLICDYRVRIGCGSFVGSFLEYYAADIS YPLRKVIKQDTFRNLFPKLQNENP-V--ESMVVTSQTK-KMSF--------QKILPDRMK SARDRANKNLVDFIVNTKGTE--------------------------------------- ------------------------SHLLAILKGTKGSRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDEKMLTLIRDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDAKIIFEKR---RKP------------- -------------------------------------------LTN-------------- -----------EA----------------------------------------------- --P-------------------------------------------- >ENSECAP00000002101 ------------------------------------------------------M--DA- EYVLCNWKDQLWPAKVLSRSETSSNS--KRKKTFSLEVQILSLDEKIQVESTETKILNKS KIEAIASSL---AAQSEVGAPPREETTYERSLKVALDVLNERTNLSE-A----------- --------------------------SSSDEEE--------------------------- --------------------------------------------------------TTTL ------------SE---NVQEKLSNS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KKYRKHEGD---------------------- ------------------------------------------------------------ --------LLKRLEESE------------------------------------------- ---------------------------------------NPTS-LLVSSDND-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLQEDKSHAHATIDTIPSEME----------------------------------- ------------------------------------------------------------ ---------TKSSQNSSWYQTFPSLS-ED----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEN----------------- -------------------------------KKKIDIS---------------------- -TVMSLH---------STIKEEGACVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FTP-----------------------------TLPS--------------------- ------------------------------------------------------------ ------------------DIFTVP-KE--------------------------------- ------------------------------------------------------------ ------------------------------LKGETQ------------------------ ---------------------VIC------------------------------P--ETI PTSSECPT----------------------------------VSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCSDTSQNQPIVESE TGAVA------------------------------------------------SPGPCSL E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSLSASNRVLDYSVLLVDNERNLQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELG--E-EPQ----A------- -----------------------------------------------SDKSVHLNPIDAS VF-------DDS------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFVFHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPAV------ ------------------------------VKSIRRKEKKASVLFVEANMNPE-KRGIRV PFRRLKKFDCKEKQALVDKAREDYSESIDWCISLICDYRVRIGCGSFSGSFLEYYAADIS YPIRKVLKQDTFRNLFPKLHNEDS-V--ESMVVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNARGTE--------------------------------------- ------------------------NHLLAILKGTKGSRWLKAFLNANRFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDERMLALIRDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDAKIISEKR---RKP------------- -------------------------------------------LTS-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSEASP00005000843 ------------------------------------------------------M--DA- EYVLCNWKDQLWPAKVLSRSETSSNS--KRKKTFSLEVQILSLDEKIQVESTETKILNKS QIEAIASSL---AAQSEVGAPPREETTYERSLKVALDVLNERTNLSE-A----------- --------------------------SSSDEEE--------------------------- --------------------------------------------------------TTTL ------------SE---NVQEKLSNS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KKYRKHEGD---------------------- ------------------------------------------------------------ --------LLKRLEESE------------------------------------------- ---------------------------------------NPTS-LLVSSDND-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----FLQEDKSHAHATIDTIPSEME----------------------------------- ------------------------------------------------------------ ---------TKSSQNSSWYQTFPSLS-ED----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEN----------------- -------------------------------KKKIDIS---------------------- -TVMSLH---------STIKEERACVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FTP-----------------------------TLPS--------------------- ------------------------------------------------------------ ------------------DIFTVP-KE--------------------------------- ------------------------------------------------------------ ------------------------------LKGETQ------------------------ ---------------------VIC------------------------------P--ETI ATSSECPT----------------------------------VSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCSDTSQNQPIVESE TGAVA------------------------------------------------SPGPCSL E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSLSASNRVLDYSVLLVDNERNLQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELG--E-EPQ----A------- -----------------------------------------------SDKSVHLNPIDAS VF-------DDS------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFVFHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPAV------ ------------------------------VKSIRRKEKKASVLFVEANMNPE-KRGIRV PFRRLKKFDCKEKQALVDKAREDYSESIDWCISLICDYRVRIGCGSFSGSFLEYYAADIS YPIRKVLKQDTFRNLFPKLHNEDS-M--ESMVVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNARGTE--------------------------------------- ------------------------NHLLAILKGTKGSRWLKAFLNANRFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDERMLALIRDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDAKIISEKR---RKP------------- -------------------------------------------LTS-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSPSMP00000018080 ------------------------------------------------------M--DA- EYVLCNWKDQLWPAKVLSRSEISSNS--KRKKAYSLEVQILSLDEKIKVESTETKILNKS QIEAIASSL---AVQSEVSAPPAEETAYGRALKVALDILNEKTNLSE-S----------- --------------------------SISDEEE--------------------------- --------------------------------------------------------TSIL ------------FE---NALQKLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKYRKHEGD---------------------- ------------------------------------------------------------ --------LPKYLEESE------------------------------------------- ---------------------------------------NSPY-LLISSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLYDDK-------------------------------------------------- ---------------------------------------LKVHTTVDTI----------- ----AVEIDTKSSQNSSWDQTFPSLSDDD----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKED----------------- -------------------------------KKKISIS---------------------- -TVVSVH---------SPVKEEDTCVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FVP-----------------------------SSPS--------------------- ------------------------------------------------------------ ------------------DILIVS-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEDTQ------------------------ ---------------------AIC------------------------------P--ETL AVSSECSV----------------------------------LSE-NVEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCFDASENQPSMESE MSAAT------------------------------------------------STESCSW E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SQPSCSASNPVLDYS-LLENNERNLQ------------------------------ --------------------------------------------RPDFE----------- --------------------------------------EPG--E-EVQ----A------- -----------------------------------------------SDTSLPQDPVNAS LL-------DDS------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFLLHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPAV------ ------------------------------VKSIRRKERKASVLFVEANMNPE-KKGIRV TFRRLKKFDCKEKQTLVDKAREEYSESIDWCISLICDYRVRIGCGSFSGSFLEYYAADIS YPLRKVIKKDTFRSMFPKLHNENT-G--ESMVVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------SHLLAILKGKKGSRWLKSFLNANRFMPCIETYFEDE DQLDEVVKYLQEV-Y-KQIDERMLTRIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGYR----ERELYDSKIIFEKR---RRP------------- -------------------------------------------LTN-------------- -----------EA----------------------------------------------- --R-------------------------------------------- >ENSMICP00000005645 ------------------------------------------------------M--DA- EYVLCNWKDQLWPAKVLSRSETSSNS--KRKKAFSLEVQILSLDEKITVDSTETKILNKS QIEAIASSL---AVQSEVSAPPAEETAYGRSLKVALDILNERKNLSE-S----------- --------------------------SISDEEK--------------------------- --------------------------------------------------------TSIV ------------FQ---NTPQKLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KKYRKHEGD---------------------- ------------------------------------------------------------ --------LPKYLEESE------------------------------------------- ---------------------------------------NSPY-LLISSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLYDDKSQMHTTIGSIPSEIET---------------------------------- ------------------KSS---PKYSWCQTFPSFSDY--------------------- ---------------------------------DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKED----------------- -------------------------------KKKASIS---------------------- -TVVSVH---------STVKDEDTYVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FVP-----------------------------SLPS--------------------- ------------------------------------------------------------ ------------------DILITP-KV--------------------------------- ------------------------------------------------------------ ------------------------------LKEETQ------------------------ ---------------------AIC------------------------------P--ETI TVSSECSV----------------------------------LSE-NVDDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NSCFDASENQPSVESE MGAAT------------------------------------------------STEGCSR E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SQPSFSASNPVLDYS-LLANNERNLQ------------------------------ --------------------------------------------RVDFE----------- -------------------------------------------E-EVQ----A------- -----------------------------------------------SDKSLPLDPVNTS LL-------DDN------------------------------------------------ DEDEE------------------------------------------------------- ---------------------------------------------LPRFILHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFDTGMIVWFKYQKYPFWPAV------ ------------------------------VKSIRRKEKKASILFVEANMNPQ-KKGIRV TFRRLKKFDCKEKQTLVDKAREEYSESIDWCISLICDYRVRLGCGSFSGSFLEYYAADIS YPIRKVIKQDTFRNRFPRLQNEDI-G--ESMVVTSQAK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------NHLMAILKGTKGSRWLKSFLNANRFMPCIETYFEDE DQLDEVVKYLQEV-Y-KQIDERMLTLIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDAKIIFEKR---RKP------------- -------------------------------------------LTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSMLUP00000007731 ------------------------------------------------------M--DA- EYVLCNWKDQLWPAKVLSRCETSSNS--KRKKTFSLEVQILSVNEKIKVESKETKILNKS QIEAIASSL---AAQSEGSYPPREETAYARSLKMALGILNKRTNLNQ-S----------- --------------------------SSSDEEE--------------------------- --------------------------------------------------------TTTL ------------SQ---NVPQKLSNS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KKYRKPKGN---------------------- ------------------------------------------------------------ --------LSKCLEERE------------------------------------------- ---------------------------------------IPTF-LLVSSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLYDDKSQVHATVDTIPSEME----------------------------------- ------------------------------------------------------------ ---------TKSSQNSSWCQIFPPLS-E-----ED------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KKKIDIP---------------------- -TIMPLG---------STIKEEGAYVKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FTP-----------------------------TSPP--------------------- ------------------------------------------------------------ ------------------DIFIVP-KS--------------------------------- ------------------------------------------------------------ ------------------------------LKEEPE------------------------ ---------------------DLC------------------------------P--KTL AISSECSA----------------------------------FLE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NSCLDTSQNQP-VESE TGALA------------------------------------------------SPSYCSL E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSFSASNRVRDCS-LRGNNERSGQ------------------------------ --------------------------------------------NPDFE----------- --------------------------------------EHG--E-ELQ----A------- -----------------------------------------------SDKSVPLNPVDTS VL-------DDD------------------------------------------------ EEDEV------------------------------------------------------- ---------------------------------------------LPPVVFHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEAGMIVWFKYKKYPFWPAI------ ------------------------------VKSIRRKEKKASVIFVEANMNRE-KRGIRV LLRRLKKFDCKEKQALVDKAREDYSESIDWCISLICDYRVRLGCGSFTGSFLEYYAADIS YPIRKVIRQDTFRNLFPKLHNEDS-M--EPMAMTSQTK-RMSF--------KKILPDRMK SARDRANRNLVDFIVNAKGAE--------------------------------------- ------------------------NHLLSILNGTKASRWLKSFLKAKRFTPCIETYFEDE DQLDEVVQYLQEI-Y-KKINERMLARIRDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYQEAEAKYLKGPS------------------------- -------------------LGYR----ERELFDSKILVEKR---RKP------------- -------------------------------------------STK-------------- -----------QA----------------------------------------------- --H-------------------------------------------- >ENSMMUP00000030703 ------------------------------------------------------M--ES- EYVLCHWKDQLWPAKVLSRSETSSNS--KRKMGFSLEVQILSLDEKIKMDSTETEILNKS QIEAIAASL---GLQSEDSALPKEETAYGRSLKVALDILNERTNLSQ-A----------- --------------------------STSDEEE--------------------------- --------------------------------------------------------ITML ------------SQ---NVPQKQSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKYRKDEAD---------------------- ------------------------------------------------------------ --------LPECLQESE------------------------------------------- ---------------------------------------NSAC-LLASSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLYDDKSQVHTMANTIPSEVE----------------------------------- ------------------------------------------------------------ ---------TKSLQNSSWCETFHSLS-ED----ND------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEN----------------- -------------------------------KNKIDIS---------------------- -AVMSVH---------SAVKEESAYVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FAP-----------------------------PLSS--------------------- ------------------------------------------------------------ ------------------DILTMP-KT--------------------------------- ------------------------------------------------------------ ------------------------------LKEESQ------------------------ ---------------------DPC------------------------------P--ETL AVPSECSA----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCLDTSQNQPSVESE MGAAA------------------------------------------------CPGSCSR E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSFSASNPVWDYS-RLMNSERNFQ------------------------------ --------------------------------------------RVDFE----------- --------------------------------------ELE--E-DGQ----A------- -----------------------------------------------SDKSLLPSRINLS LL-------DDD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFILHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRPFEAGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLFIEANMNSE-KKGIRV NFRRLKKFDCKEKQMLVNKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKEIKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGAE--------------------------------------- ------------------------NHLLAIVNGTKGSRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEV-Y-NQIDKIMPTWIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPC------------------------- -------------------LGYR----ERELFDAKIIYEKR---RKP------------- -------------------------------------------PTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSTGEP00000017495 ------------------------------------------------------M--ES- EYVLCHWKDQLWPAKVLSRSETSSNS--KRKMGFSLEVQILSLDEKIKMDSTETEILNKS QIEAIAASL---GLQSEDSALPTEETAYGRSLKVALDILNERTNLSQ-A----------- --------------------------STSDEEE--------------------------- --------------------------------------------------------ITML ------------PQ---NVPQKQSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKYRKDEAD---------------------- ------------------------------------------------------------ --------LPECLQESE------------------------------------------- ---------------------------------------NSAC-LLASSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLYDDKSQVHTMANTIPSEVE----------------------------------- ------------------------------------------------------------ ---------TKSLQNSSWCETFHSLS-ED----ND------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEN----------------- -------------------------------KNKIDIS---------------------- -AVMSVH---------SAVKEESAYVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FAP-----------------------------PLSS--------------------- ------------------------------------------------------------ ------------------DILTMP-KT--------------------------------- ------------------------------------------------------------ ------------------------------LKEESQ------------------------ ---------------------DTC------------------------------P--ETL AVPSECSA----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCLDTSQNQPSVESE MGAAA------------------------------------------------CPGSCSR E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSFSASNPVWDYS-RVMNSERNFQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELE--E-DGQ----A------- -----------------------------------------------SDKSLLPSRINLS LL-------DDD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFILHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRPFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLFIEANMNSE-KKGIRV NFRRLKKFDCKEKQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKEIKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGAE--------------------------------------- ------------------------NHLLAIVNGTKGSRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEV-Y-NQIDKIMPTWIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPC------------------------- -------------------LGYR----ERELFDAKIIYEKR---RKP------------- -------------------------------------------PTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSCSAP00000017684 ------------------------------------------------------M--ES- EYVLCHWKDQLWPAKVLSRSETSSNS--KRKMGFSLEVQILSLDEKIKMDSTETEILNKS QIEAIAASL---GLQSEDSALPTEETAYGRSLKVALDILNERTNLSQ-A----------- --------------------------STSDEEE--------------------------- --------------------------------------------------------ITML ------------SQ---NVPQKQSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKYRKDEAD---------------------- ------------------------------------------------------------ --------LPECLQESE------------------------------------------- ---------------------------------------NSAC-LLASSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLYDDKSQVHTMADTIPSEVE----------------------------------- ------------------------------------------------------------ ---------TKSLQNSSWCETFHSLS-ED----ND------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEN----------------- -------------------------------KNKIDIS---------------------- -AVMSVH---------SAVKEESAYVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FAP-----------------------------PLSS--------------------- ------------------------------------------------------------ ------------------DILTMP-KT--------------------------------- ------------------------------------------------------------ ------------------------------LKEESQ------------------------ ---------------------DTY------------------------------P--ETL AVPSECSA----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCLDTSQNQPAVESE MGAAA------------------------------------------------CPGSCSR E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSFSASNPVWDYS-RLMNSERNFR------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELE--E-DGQ----A------- -----------------------------------------------SDKSLLPSRINLS LL-------DDD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFILHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRPFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLFIEANMNSE-KKGVRV NFRRLKKFDCKEKQMLVEKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKEIKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGAE--------------------------------------- ------------------------NHLLAIVNGTKGSRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEV-Y-NQIEQIMPTWIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPC------------------------- -------------------LGYR----ERELFDAKIIYEKR---RKP------------- -------------------------------------------PTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSPTEP00000002028 ------------------------------------------------------M--ES- EYVLCHWKDQLWPAKVLSRSETSSDS--KRKKGFSLEVQILSLDEKIKMDSTETEILNKS QIEAIAASL---GLQSEDSAPPTEETAYGRSLKMALDILNERTNLIQ-A----------- --------------------------STSDEEE--------------------------- --------------------------------------------------------ITML ------------SQ---NVPQKQSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKYRKDEAD---------------------- ------------------------------------------------------------ --------LPECLQESE------------------------------------------- ---------------------------------------NSAC-LLASSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLYDDKSQVHTMADTIPSEVE----------------------------------- ------------------------------------------------------------ ---------TKSLQNSSWCETFHSLS-ED----ND------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEN----------------- -------------------------------KNKIDIS---------------------- -AVMSVH---------SAVKEEGACVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FAP-----------------------------PLSS--------------------- ------------------------------------------------------------ ------------------DILTMP-KT--------------------------------- ------------------------------------------------------------ ------------------------------LKEESQ------------------------ ---------------------DTC------------------------------P--ETL AVPSEFSA----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCLDTSQNQPSVESE MGAAA------------------------------------------------YPGSCSR E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSFSASNPVWDYS-RLMNSERNFQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELE--E-DGQ----A------- -----------------------------------------------SDKSLLPSRINLS LL-------DDD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFILHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRPFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLFVEANMNSE-KKGIRV NFRRLKKFDCKEKQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYFAADIS YPVRKEIKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVKAKGAE--------------------------------------- ------------------------NHLLAIVNGTKGSRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEV-Y-NQIDQIIPTWIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPC------------------------- -------------------LGYR----ERELFDAKIIYEKR---RKP------------- -------------------------------------------PTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSRROP00000007853 ------------------------------------------------------M--ES- EYVLCHWKDQLWPAKVLSRSETSSNS--KRKKGFSLEVQILSLDEKIKMDSTETEILNKS QIEAIAASL---GLQSEDSAPPTEETAYGRSLKVALDILNERTNLSQ-A----------- --------------------------STSDEEE--------------------------- --------------------------------------------------------ITML ------------SQ---NVPQKQSDL---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKYRKDEAD---------------------- ------------------------------------------------------------ --------LPECLQESE------------------------------------------- ---------------------------------------NSAC-LLASSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLYDDKSQVHTMADTIPSEVE----------------------------------- ------------------------------------------------------------ ---------TKSLQNSSWCETFHSLS-ED----ND------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEN----------------- -------------------------------KNKIDIS---------------------- -AVMSVH---------SAVKEESACVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FAP-----------------------------PLSS--------------------- ------------------------------------------------------------ ------------------DILTMP-KT--------------------------------- ------------------------------------------------------------ ------------------------------LKEESQ------------------------ ---------------------DTC------------------------------P--ETL AVPSECSA----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCLDTSQNQPSMESE MGAAA------------------------------------------------YPGSCSR E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSFSASNPVWDYS-RLMNSERNFQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELE--E-DGQ----A------- -----------------------------------------------SDKSLLPSRINLS LL-------DDD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFILHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRPFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLFVEANMNSE-KKGIRV NFRRLKKFDCKEKQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKEIKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGAE--------------------------------------- ------------------------NHLLAIVNGTKGSRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEV-Y-NQIDQIIPTWIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPC------------------------- -------------------LGYR----ERELFDAKIIYEKR---RKP------------- -------------------------------------------PTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSRBIP00000014134 ------------------------------------------------------M--ES- EYVLCHWKDQLWPAKVLSRSETSSNS--KRKKGFSLEVQILSLDEKIKMDSTETEILNKS QIEAIAASL---GLQSEDSAPPTEETAYGRSLKVALDILNERTNLSQ-A----------- --------------------------STSDEEE--------------------------- --------------------------------------------------------ITML ------------SQ---NVPQKQSDL---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKYRKDEAD---------------------- ------------------------------------------------------------ --------LPECLQESE------------------------------------------- ---------------------------------------NSAC-LLASSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLYDDKSQVHTMADTIPSEVE----------------------------------- ------------------------------------------------------------ ---------TKSLQNSSWCETFHSLS-ED----ND------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEN----------------- -------------------------------KNKIDIS---------------------- -AVMSVH---------SAVKEESACVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FAP-----------------------------PLSS--------------------- ------------------------------------------------------------ ------------------DILTMP-KT--------------------------------- ------------------------------------------------------------ ------------------------------LKEESQ------------------------ ---------------------DTC------------------------------P--ETL AVPSECSA----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCLDTSQNQPSMESE MGAAA------------------------------------------------YPGSCSR E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSFSASNPVWDYS-RLMNSERNFQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELE--E-DGQ----A------- -----------------------------------------------SDKSLLPSRINLS LL-------DDD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFILHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRPFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLFVEANMNSE-KKGIRV NFRRLKKFDCKEKQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKEIKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGAE--------------------------------------- ------------------------NHLLAIVNGTKGSRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEV-Y-NQIDQIIPTWIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPC------------------------- -------------------LGYR----ERELFDAKIIYEKR---RKP------------- -------------------------------------------PTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSPPYP00000023059 ------------------------------------------------------M--ES- EYVLCNWKDQLWPAKVLSRSETSSNS--KRKKAFSLEVQILSLDEKIKLDSTETKILNKS QIEAIAASL---GLQSEDSAPPTEETAYGRSLKVALGILNERINLSQ-A----------- --------------------------STSDEEE--------------------------- --------------------------------------------------------ITML ------------SQ---NVPQKQSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKYRKDEGD---------------------- ------------------------------------------------------------ --------LPGCLEESE------------------------------------------- ---------------------------------------NSAC-LLAHSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLYDDKSQAHTMVDTIPSEVE----------------------------------- ------------------------------------------------------------ ---------TKSLQNSSWCETFPSLS-ED----SD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEN----------------- -------------------------------KNKIDIS---------------------- -AVMSVH---------SAVKEESARVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FAP-----------------------------PLSS--------------------- ------------------------------------------------------------ ------------------DILIMP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEGQ------------------------ ---------------------DTC------------------------------P--ETL AVPSECSA----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCLDTSQNQTSMESE MRTAA------------------------------------------------CPGSCSR E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CEVSFSASNPVWDYS-RLMSSERNFQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELE--E-EGQ----A------- -----------------------------------------------SDKSLLPSRINLS LL-------DDD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFILHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRPFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLFVEANMNSE-KKGIRV NFRRLKKFDCKEKQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKEIKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------NHLLAIVNGTKGSRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEV-Y-NQIDQIMPTWIKEDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPC------------------------- -------------------LGYR----ERELFDAKIIYEKR---RKP------------- -------------------------------------------PTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSP00000338641 ------------------------------------------------------M--ES- EYVLCNWKDQLWPAKVLSRSETSSNS--KRKKAFSLEVQILSLDEKIKLDSTETKILNKS QIEAIAASL---GLQSEDSAPPTEETAYGRSLKVALGILNERTNLSQ-A----------- --------------------------STSDEEE--------------------------- --------------------------------------------------------ITML ------------SQ---NVPQKQSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKYRKDEGD---------------------- ------------------------------------------------------------ --------LPGCLEERE------------------------------------------- ---------------------------------------NSAC-LLASSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLYDDKSQAPTMVDTIPSEVE----------------------------------- ------------------------------------------------------------ ---------TKSLQNSSWCETFPSLS-ED----ND------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEN----------------- -------------------------------KNKIDIS---------------------- -AVMSVH---------SAVKEESACVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FAPP--------------------------LSPLSS--------------------- ------------------------------------------------------------ ------------------DMLIMP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEESE------------------------ ---------------------DTC------------------------------L--ETL AVPSECSA----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCLDTSQNQPSMESE MGAAA------------------------------------------------CPGSCSR E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CEVSFSASNPVWDYS-HLMSSERNFQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELE--E-EGQ----A------- -----------------------------------------------SDKSLLPSRINLS LL-------DDD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFILHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------THPFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLFVEANMNSE-KKGIRV NFRRLKKFDCKEKQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKETKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------NHLLAIVNGTKGSRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEV-C-NQIDQIMPTWIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPC------------------------- -------------------LGYR----ERELFDAKIIYEKR---RKA------------- -------------------------------------------PTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSPTRP00000038089 ------------------------------------------------------M--ES- EYVLCNWKDQLWPAKVLSRSETSTNS--KRKKAFSLEVQILSLDEKIKLDSTETKILNKS QIEAIAASL---GLQSEDSAPPTEETAYGRSLKVALGILNERTNLSQ-A----------- --------------------------STSDEEE--------------------------- --------------------------------------------------------ITMQ ------------SQ---NVPQKQSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKYRQDEGD---------------------- ------------------------------------------------------------ --------LPGCLEERE------------------------------------------- ---------------------------------------NSAC-LLASSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLYDDKSQAPTMVDTIPSEVE----------------------------------- ------------------------------------------------------------ ---------TKSLQNSSWCETFPSLS-ED----ND------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKEN----------------- -------------------------------KNKIVIS---------------------- -AVMSVH---------SAVKEESACVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FAPP--------------------------LSPLSS--------------------- ------------------------------------------------------------ ------------------DILIMP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEESQ------------------------ ---------------------DTC------------------------------P--ETL AVPSECSA----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCLDTSQNQPSMESE MGAAA------------------------------------------------CPGSCSR E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CEVSFSASNPVWDYS-HLMSSERNFQ------------------------------ --------------------------------------------RLDFE----------- --------------------------------------ELE--E-EGQ----A------- -----------------------------------------------SDKSLLPSRINLS LL-------DDD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFILHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRPFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLFVEANMNSE-KKGIRV NFRRLKKFDCKEKQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKETKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------NHLLAIINGTKGSRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEV-C-NQVDQIMPTWIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPC------------------------- -------------------LGYR----ERELFDAKIIYEKR---RKA------------- -------------------------------------------PTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSSTOP00000016689 ------------------------------------------------------M--EV- EYVLCNWKDQLWPAKVLSRSETSSDS--KRQKTISLEVQILSLDEKIEVDITETKILEKS QVEAIASSL---VLQLEDNAPPQEETAYRRSLKVALDILNERKKMSQ-A----------- --------------------------SISHEEE--------------------------- --------------------------------------------------------TIVI ------------SD---NEPQKLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KKYRRHEED---------------------- ------------------------------------------------------------ --------LQESLEENK------------------------------------------- ---------------------------------------NPTS-LIISSESG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------N------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLPDDKLQVNTTIDT-PSEME----------------------------------- ------------------------------------------------------------ ---------TKSSQN-PICQTFPSLS-ED----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKE------------------ -------------------------------KKKIDTS---------------------- -AILSVS---------STVKEENAHVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FVP-----------------------------SLSS--------------------- ------------------------------------------------------------ ------------------DIVTMP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEEK------------------------ ---------------------HIC------------------------------S--ETT AVSSECST----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNP---------------- --------------------------------------------NPCTDATQDQPSVESE IGAAT------------------------------------------------SSASCSG E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQASVSASNPVLDYS-LLVNNERSFQ------------------------------ --------------------------------------------RLDLE----------- --------------------------------------ELE--E-DIQ----A------- -----------------------------------------------SDKSPNLNPVSAS AL-------DDN------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFILNYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPAV------ ------------------------------VKSIRRKERKASVLFVEANINPE-KKGIRV PFRRLKKFDCKEKQALVDKAREEYSESIDWCISLICDYRVRIGCGSFTGSFLEYYAADIS YPIRKAIKQDTFRNRFPKLQSDDT-V--EQMVVTSQTK-KMAF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------NHLLAILKGTKASRWLKSFLNANRFTPCIETYFEDD DQLDEVVKYLQEI-Y-KQIDESMLTRIKHDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIFSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDAKIIFEKR---RKP------------- -------------------------------------------LTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSUPAP00010020686 ------------------------------------------------------M--EV- EYVLCNWKDQLWPAKVLSRSETSSDR--KRQKTISLEVQILSLDEKIEVDITETKILEKS QVEAIASSL---VLQSEDNAPPQEETAYRRSLKVALDILNERKKMSQ-A----------- --------------------------SISHEEE--------------------------- --------------------------------------------------------TIVI ------------SD---NEPQKLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KKYRRHEED---------------------- ------------------------------------------------------------ --------LQESLEENK------------------------------------------- ---------------------------------------NPTS-LIISSESG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------N------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLPDDKLQVNTTIDT-PSEME----------------------------------- ------------------------------------------------------------ ---------TKSSQN-PICQTFPSLS-ED----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKE------------------ -------------------------------KKKIDTS---------------------- -AILSVS---------STVKEENAHVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---LVP-----------------------------SLSS--------------------- ------------------------------------------------------------ ------------------DIVTKP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEEK------------------------ ---------------------NIC------------------------------S--ETT AVSSECST----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNP---------------- --------------------------------------------NPCTDATQDQPSVESE IGAAT------------------------------------------------SSASCSG E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQASVSASNPVLDYS-LLVNNERSFQ------------------------------ --------------------------------------------RLDLE----------- --------------------------------------ELE--E-DIQ----A------- -----------------------------------------------SDKSPNLNPVSAS AL-------DDN------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFILNYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPAV------ ------------------------------VKSIRRKERKASVLFVEANINPE-KKGIRV PFRRLKKFDCKEKQALVDKAREEYSESIDWCISLICDYRVRIGCGSFTGSFLEYYAADIS YPIRKAIKQDTFRNRFPKLQSDDT-V--EQMVVTSQTK-KMAF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------NHLLAILKGTKASRWLKSFLNANRFTPCIETYFEDD DQLDEVVKYLQEI-Y-KQIDESMLTRIKHDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIFSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDAKIIFEKR---RKP------------- -------------------------------------------LTN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSOGAP00000018814 ------------------------------------------------------M--DA- EYVLCNWKDQLWPAKVLSRSETSSDS--KRKKSFSLEVQILSLDEKIKVDSTETKILTKC QIEAITASL---GEQSEVSSPSTEEMTYRRSLQAALDILNESTNLSQ-A----------- --------------------------SISDDE---------------------------- --------------------------------------------------------TSTL ------------SE---NAPQNESDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPP------ ------------------------------------------------------------ -----------------------------KKYRKHEGD---------------------- ------------------------------------------------------------ --------L-----ESE------------------------------------------- ---------------------------------------NSIS-LLISSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLHDDKPQVHTTTGTIPSETE----------------------------------- ------------------------------------------------------------ ---------MKSSQSPSLCQT-SSLS-ED----ED------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKKN----------------- -------------------------------KEKVNIS---------------------- -TFVSVH---------STAKEEDVGIKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---IVP-----------------------------SLPS--------------------- ------------------------------------------------------------ ------------------DIHAVP-KV--------------------------------- ------------------------------------------------------------ ------------------------------LKEEKE------------------------ ---------------------DTC------------------------------Q--ETL DISSECSS----------------------------------LSD-IVEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPHLEASQSQPAVEPE MAATT------------------------------------------------STGSQSW E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQGSSSACNLVLDYS-LAGNRERDLQ------------------------------ --------------------------------------------ALDFE----------- --------------------------------------EL---D-EVQ----A------- -----------------------------------------------SDKSLPQNPVDVS LL-------DDD------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------LPRFILNYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------SRSYETGMIVWFKYQKYPFWPSV------ ------------------------------VKSIRRKEKKASVLFVEADMNPE-KKGVRV SFRRLKKFDCKEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFSGSFLEYYAADIS YPIRKVTKQDTFRNKFPKLHNKDA-G--EAMVVTSQTK-KMSF--------RKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------SHLLAILNGTKASRWLKSFLNANRFTPCIETYFEDE DQLDEVVKYLQEV-Y-KQIDERMLAVIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPA------------------------- -------------------LGYR----ERELFDSKILFEKR---RKP------------- -------------------------------------------PTN-------------- -----------EP----------------------------------------------- --H-------------------------------------------- >ENSDNOP00000016486 ------------------------------------------------------M--DF- RYVLCNWKDQLWPAKVLSRSETSANN--KRKKTFSLEVQILSLDEKIQVESTEIKILNKS QIEDIVSSL---VTQSETSAIPREVSAYERSLKVALDILNERTILSQ-V----------- --------------------------SISDEVE--------------------------- --------------------------------------------------------TTTL ------------SQ---DISQKQSYS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PHH------ ------------------------------------------------------------ -----------------------------KKYRTHKEDLPKNPGES-------------- --------------------------------------ENPVS----------------- ---QFSL----------------------------------------------------- -------------------------------------------------ESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SMYNDKTQVHATIRTIPSEVE----------------------------------- ------------------------------------------------------------ ---------AKSSENSSWCQSLPSLS-ED----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ENES----------------- -------------------------------KKKSDIS---------------------- -IIMSLN---------STIKEEDACVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---LTP-----------------------------ILPS--------------------- ------------------------------------------------------------ ------------------YMLTAP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKQEAQ------------------------ ---------------------DNC------------------------------P--ETL VISSEYSN----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPS------------------ --------------------------------------------NPCLEANQNQHSMESE TGAVT------------------------------------------------ASAQCSL E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----NQFSLSASNHDLDYSFLLLNNERNLQ------------------------------ --------------------------------------------RPDVE----------- --------------------------------------EF---E-EEQ----I------- -----------------------------------------------SDKSVHLNPIDAS IF-------DEN------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFVFHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMMVWFKYKKYPFWPAV------ ------------------------------VKSIRRKEKKASVLFVEPTMNPA-KKGIRV LFRRLKKFDCKEKQALVDKAREDYSESIDWCISLICDYRVRIGCGSFAGSFLEYYAADIS YPIRKAMKQDTLRDIFPKLYNEDS-V--EPTVVTSQTK-KMSL--------QKILPDRMK AARDRANRNLVDFIVKAKGTE--------------------------------------- ------------------------NHLMDILKGRKGSRWLKSFLNANRFMPCIETYFEDE DQLDEVVKYLQEF-Y-TQIDEGMLTLIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----T------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGCR----ERELFDAKIIFEKR---RKP------------- -------------------------------------------STS-------------- -----------ET----------------------------------------------- --H-------------------------------------------- >ENSOCUP00000007882 ------------------------------------------------------M--DA- EYVLCNWKDQLWPAKVLSSYETSPNS--KRKKTFSLEVQILSLEEKIIVDSSETKLLNKS QIEAIASSL---AVQSEAGASPRDETAYGRALKVALDILNERPNLSE-A----------- --------------------------SISGEEE--------------------------- --------------------------------------------------------TATL ------------AE---NAQQKLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPQ------ ------------------------------------------------------------ -----------------------------KKYRKHEGD---------------------- ------------------------------------------------------------ --------LPKYLEESE------------------------------------------- ---------------------------------------NPAS-LLVSPE-N-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLADDKSQVHTTSSIIPGEME----------------------------------- ------------------------------------------------------------ ---------TKPLLDSSWGQTFPSRS-ED----ED------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKED----------------- -------------------------------KKKIDIS---------------------- --LMPVH---------STVKEEDVYAKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---CLP-----------------------------DLPS--------------------- ------------------------------------------------------------ ------------------DTLFTP-KA--------------------------------- ------------------------------------------------------------ ------------------------------LKEEPQ------------------------ ---------------------DVC------------------------------P--GPL PDSSECST----------------------------------FSE-NIEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNP---------------- --------------------------------------------NPCLEPSQNQPSVESE VGATT------------------------------------------------STGSCSW EDQVS-------------AS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------APN----------------------------------- PALACA--------------LVANRERNLE------------------------------ --------------------------------------------RLDFD----------- --------------------------------------DL---E-EFQ----A------- -----------------------------------------------SDKSLHLNSIIDS IL-------ADD------------------------------------------------ EEEEE------------------------------------------------------- ---------------------------------------------LPRFIFQYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------KRSFETGMIVWFKYQKYPYWPAV------ ------------------------------VKSIRRKERKASVLFVEANMTPE-KKGVRV SFRRLKKFDCKEKQTLVDKAREDYSESIDWCISLICDYRVRIGCGSFAGSFFEYYAADIS YPVRKVVKQETFRNIFPKLHNEDA-V--EHMTVTSQTK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------DHLQSILNGTKGSRWLKSFLNAKRFSPCIETYFEDD DQLDEVVKYLQGV-C-NQVDEKMMTLIKHDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYKAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDSKILFEKR---RKP------------- -------------------------------------------LTK-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSTBEP00000005356 ------------------------------------------------------M--DA- EYVLCNWKDQLWPARVLSKYEVSSNS--KRKNTFSLEVQILTLDEKINVDSADTKILSRS EIEALASSL---AVQSEVSA-PSEETAYGRSLKAALDILNERTNMSQ-V----------- --------------------------SIPDEED--------------------------- --------------------------------------------------------ITTL ------------FQ---DTPPRQSDP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KKYRQPEGD---------------------- ------------------------------------------------------------ --------LLKCLEGSE------------------------------------------- ---------------------------------------NPAS-LSVSSESG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TLDDDKSEIQATLGIISSDIE----------------------------------- ------------------------------------------------------------ ---------TKSSQNFSYCPSLSPLS-E-----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------EKES----------------- -------------------------------KIKIDIS---------------------- -AGMFVH---------AKVKDEGVCVKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FLPP--------------------------F-------------------------- ------------------------------------------------------------ -----------------------P-KA--------------------------------- ------------------------------------------------------------ ------------------------------VKDEAE------------------------ ---------------------DTC------------------------------P--EAL VVSSECST----------------------------------FSE-NLEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPW------------------ --------------------------------------------NPCVDAGQGQPSVESE TGAAS------------------------------------------------SSGSGSS E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CQVSVSAANHDLDYS-LLVSGDRSLL------------------------------ --------------------------------------------RLDSE----------- --------------------------------------EHE--E-EAQ----A------- -----------------------------------------------SDRPSALNPVNMS AL-------DDD------------------------------------------------ EEDEV------------------------------------------------------- ---------------------------------------------LPPLVFHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLFVEANMNPE-KKGIRV GFRRLKKFDCKEKQALVEKAREDYSESIDWCISLICDYRVRIGCGSFTGSFLEYYAADIS YPVRRAIKRDTFRNIFPKLNNEDT-M--EPMAVTSQAK-KISF--------QKTLPDRMK AARDRANRNLVDFIVNTKGTE--------------------------------------- ------------------------SHLMAILNGTKGSRWLKSFLNAKRFAPCIETYFEDE DQLDEVVKYLQEV-C-KQIDERMLALIK-DKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYSISVVDGLDYKAAEVKYLKGPS------------------------- -------------------LGYR----ERELFDAKIISEKR---RRS------------- -------------------------------------------LTN-------------- -----------EA----------------------------------------------- --R-------------------------------------------- >ENSCPOP00000010914 ------------------------------------------------------M--NP- EYVLCNWKDQVWPAKVLSRSKTSSRG--KRKSTSSLEVQILSLDETVKVKSTETKTLNKS EIEAIVSSL---AVQSEVSDVHREDTPYGRALKEALHILDKRAILSQ-A----------- --------------------------SITDEGE--------------------------- --------------------------------------------------------TSIH ------------TE---NVGQELSDI---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPC------ ------------------------------------------------------------ -----------------------------KRYQKHE------------------------ --------------------------------------E--------------------- -----------CFEENE------------------------------------------- ---------------------------------------DQTP-PLLSSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------V------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLTDDEVEVHPTVDTVQNEEEIQSPENF---------------------------- ---------------TSYQAS--------------------------------------- ----------------------PLLS-ED----ND------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKED----------------- -------------------------------KIKI--S---------------------- -TFM---------SADSTVKGESELVEDEKCVASSSSKDEK------------------- -----------------------------------C------------------------ VQSSLSKDE--------------------------------------------------- ------------------------------------------------------------ --NCVP-----------------------------SSSS--------------------- ------------------------------------------------------------ ------------------DILTAS-KG--------------------------------- ------------------------------------------------------------ ------------------------------LKEDTQ------------------------ ---------------------DTC------------------------------P--DIL PVSSECPT----------------------------------FSE-TIEDPEE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNP---------------- --------------------------------------------NPRLDVSQGQSPVESE VGAET------------------------------------------------SSPSCSW Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----NQAAFSSTRPVLDYS-LLVNSERYLQ------------------------------ --------------------------------------------RLDIE----------- --------------------------------------EFE--E-DAL----A------- -----------------------------------------------SDKSLRLNAASLS AL-------DDD------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFIFQYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFEAGMIVWFKYKKYPFWPAV------ ------------------------------VKSIRRKEKKASVLFVEANMNPE-KKGIRV PLRSLKKFDCKEKQELVDKAREEYNESIDWCISLICDYRVRIGCGSFSGSFLEYYAADIS CPMRKAIQRDTFRNMFPKLPNEDT-V--EQMVVTSQSK-KRSF--------QKILPDRMK AARDRANRNLVDYIVNAKGTD--------------------------------------- ------------------------SHLVAILKRRKESRWLKSFLHQSTIMPCIETYIEDE DQLDEIVRYLQVL-Y-DHIDKKLQTLIRDDKINFILQVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------VICSISAVDGLDYETAEAKYLKGPS------------------------- -------------------LGCR----ERELFDAKILVGKR---RKR------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSHGLP00000027751 ------------------------------------------------------M--NA- EYVLCKWKDQIWPAKVLSRSETSSDG--KRKNTFSLEVQILSLDETVKVESTETKVLNKS DIEAIISSL---PVQSEVSASPREEMPYGRALKEALDILNKRTNLSQ-A----------- --------------------------SITDEEE--------------------------- --------------------------------------------------------TTIL ------------PE---NVPQSLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KRYRKNEGA------LSKYPKENEDQTSWLL SSESDDSVSNDKLEGKTTDDTIQNEVETKSPQNSSWFQE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TFSLLS-ED----ND------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKQN----------------- -------------------------------K---------------------------- ------KEISTRISGNSTVKGVSAHVKDET------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---CVQ-----------------------------FLSS--------------------- ------------------------------------------------------------ --------------------LTAS-KV--------------------------------- ------------------------------------------------------------ ------------------------------SNEEAQ------------------------ ---------------------NTC------------------------------L--DTL PVSSKGST----------------------------------FSE-TIEDPEE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNP---------------- --------------------------------------------NPFLDANRNQLCMESE MSTAT------------------------------------------------SPPSCSW E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SQASFSPSNSFLDYS-HLVNNNRSLQ------------------------------ --------------------------------------------SLDIE----------- --------------------------------------ESE--E-DIQ----A------- -----------------------------------------------SDKSSHVDTVSAS AL-------DDN------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFVFHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPSV------ ------------------------------IKNIRRKEKKASVLFVEANMNPE-KKGIRV SFRRLKKFDCKEKQALVDKAREEYSESIDWCISLICDYRVRLGCGSFSGSFLEYYAADIS YPMRKVVKHDTFRNMFPKLQNEDS-V--EQMVVTSQSK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------SHLLAILKGTKGSRWLKSFLHAKRFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDKRMLTLIKDDKINFILEVLLP-------E----------- ------------------------------------------------------------ -----T------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDSKIIFEKR---RKT------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSHGLP00100027619 ------------------------------------------------------M--NA- EYVLCKWKDQIWPAKVLSRSETSSDG--KRKNTFSLEVQILSLDETVKVESTETKVLNKS DIEAIISSL---PVQSEVSASPREEMPYGRALKEALDILNKRTNLSQ-A----------- --------------------------SITDEEE--------------------------- --------------------------------------------------------TTIL ------------PE---NVPQSLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KRYRKNEGA------LSKYPKENEDQTSWLL SSESDDSVSNDKLEGKTTDDTIQNEVETKSPQNSSWFQE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TFSLLS-ED----ND------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKQN----------------- -------------------------------K---------------------------- ------KEISTRISGNSTVKGVSAHVKDET------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---CVQ-----------------------------FLSS--------------------- ------------------------------------------------------------ --------------------LTAS-KV--------------------------------- ------------------------------------------------------------ ------------------------------SNEEAQ------------------------ ---------------------NTC------------------------------L--DTL PVSSKGST----------------------------------FSE-TIEDPEE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNP---------------- --------------------------------------------NPFLDANRNQLCMESE MSTAT------------------------------------------------SPPSCSW E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SQASFSPSNSFLDYS-HLVNNNRSLQ------------------------------ --------------------------------------------SLDIE----------- --------------------------------------ESE--E-DIQ----A------- -----------------------------------------------SDKSSHVDTVSAS AL-------DDN------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFVFHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPSV------ ------------------------------IKNIRRKEKKASVLFVEANMNPE-KKGIRV SFRRLKKFDCKEKQALVDKAREEYSESIDWCISLICDYRVRLGCGSFSGSFLEYYAADIS YPMRKVVKHDTFRNMFPKLQNEDS-V--EQMVVTSQSK-KMSF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------SHLLAILKGTKGSRWLKSFLHAKRFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDKRMLTLIKDDKINFILEVLLP-------E----------- ------------------------------------------------------------ -----T------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGYR----ERELFDSKIIFEKR---RKT------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSFDAP00000011158 ------------------------------------------------------M--NA- EYVLCNWKDQVWPAKVLSRSETSSDG--KRKNTLVLEVQILSLDETIKVESTETKILNKS EIEAIISSI---QVQSEVNAPPREETPYERALKEALDILNKRTDLTQ-A----------- --------------------------SIT-EEE--------------------------- --------------------------------------------------------TTIL ------------PE---NIPQNLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPY------ ------------------------------------------------------------ -----------------------------KRHRKNEEA------LSKYPKENEDQICIVI SSESEDSNSNDKLEVQITNDTIQNEEETKSPRNSSLCQE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TFSLLS-ED---EDD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKED----------------- -------------------------------K---------------------------- ------KEISTSISGNSTIKGES---EDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---CVQ-----------------------------FLSS--------------------- ------------------------------------------------------------ ------------------DNITAP-KV--------------------------------- ------------------------------------------------------------ ------------------------------SKEEGQ------------------------ ---------------------NTC------------------------------L--DTL PVSSEYST----------------------------------FSE-TIEDPEE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNP---------------- --------------------------------------------NPCLDANQNQPCMESE VSAAT------------------------------------------------SAPSCSW E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SPASFSASNSFLDYS-HLVNNDRSLH------------------------------ --------------------------------------------NLDIE----------- --------------------------------------EFE--E-DIQ----A------- -----------------------------------------------SDKSLHIDPVSSS AL-------DDN------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFVFHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PRSFETGMIVWFKYQKYPFWPSV------ ------------------------------IKNIRRKEKKASVLFVEANMNPE-KKGVRV PFRRLKKFDCKEKQALVDEAREEYSESIDWCISLICDYRVRLGCGSFSGSFLEYFAADIS YPMRKAFKHDTFRNMFPKLQNEDT-G--EQMVVTSQSK-KMSF--------QKILPDRMK AARDRANRNLVDFIVNAKGAE--------------------------------------- ------------------------SHLLAILKGTKGSKWLKSFLHAKRFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDKRMLTLIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPA------------------------- -------------------LGYR----ERELFDSKIIFEKR---RKT------------- -------------------------------------------LP--------------- ------------------------------------------------------------ --N-------------------------------------------- >ENSCLAP00000025311 ------------------------------------------------------M--SA- EYVLCNWKGQAWPGKVLSRSATSSGG--KGKKTFSLEVQILSLDETVKVRSTETKVLRKS EIEAIVSSL---TVQSEVSALPREETPYERALKEALDILNKGTNLSR-A----------- --------------------------SMTDEEE--------------------------- --------------------------------------------------------ATVQ ------------SE---NVEQELSYR---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPR------ ------------------------------------------------------------ -----------------------------KRYRKDE------------------------ --------------------------------------E--------------------- -------DLPNCLKENE------------------------------------------- ---------------------------------------DQIF-LLLSSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLSDGKLEVQTAVDPIQNETEVESP------------------------------- ------------------QSS--------------------------------------- ----------------SSCLTFPLLS-ED----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKEN----------------- -------------------------------KQKI--S---------------------- -VIMAVK---------STVKGESEYIKDEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---SVP-----------------------------SLSS--------------------- ------------------------------------------------------------ ------------------DILTAS-EV--------------------------------- ------------------------------------------------------------ ------------------------------SKDEAQ------------------------ ---------------------NTS------------------------------L--NTL PVSSECST----------------------------------VSE-TTEDPEE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNL---------------- --------------------------------------------NTCLDASQNQPCVGSE VDAAT------------------------------------------------SPPSCSW E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SQASFSACNSVLGYS-LLVNNERSLQRQGSE------------------------- --E--------------------------IEEHAQAPDRSVNLNS--------------- ------------------------------------------------------------ --------------------------------------------------------VSAS AL-------EES------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPRFVLQYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PQSFETGTMVWFKYQKNPFWPAV------ ------------------------------IKSVRPKERKASVLFVEANMSPE-KKGIRV NFRRLKKYDCKEKQELVEKAREEYSESIDWCISLICDYRVRLGCGSFSGSFLEYYAADIS YPMRKIIQCDTFRYRFPKLNNEDT-M--EQMAVTSQTK-KMAF--------QKILPDRMK AARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------SHLLAILKGKKGSRWLKTFLQTNRCMPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDKRMLTLIKDDKINFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAQAKYLKGPS------------------------- -------------------LGYR----ERELFDSKILFEKR---RKH------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------- >ENSCGRP00001009884 ------------------------------------------------------M--DG- EYVLCNWKEQLWPAKVLCRSEISSSS--KRKMAFSLKVQILSLDEKITVDSKDIKVLSKA EVETIVSLL---AVESEVRVPPREETAYERALKMALEIIRERSTQSQ-E----------- --------------------------NMPNEED--------------------------- --------------------------------------------------------TTVA ------------SE---SVPQQQDDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPP------ ------------------------------------------------------------ -----------------------------KKYRK-------------------------- ----------------------------------------------------------LE SNLQ------------E------------------------------------------- ---------------------------------------DSAS-ILLCSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLSDDKLQVRTAIESIASEME----------------------------------- ------------------------------------------------------------ ---------TKSSQNFSWCQTYSSFP-DD---EDD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKEE----------------- -------------------------------KIKIDMS---------------------- -ASMSMN---------LSIKEEAEDIKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FVPPS--------------------DDLTVP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------KEE-------------------------- ------------------------------------------------------------ -------AQE------------------IPLEAPTVSAECSIFPENNMEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNQ---------------- --------------------------------------------NPCFYGSQTQSSVESE IGAES------------------------------------------------ALPGCSG EYQVSLSACNPVNSDLLLQ----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------RLDLE----------- --------------------------------------DLE--E-EAR----A------- -----------------------------------------------SGKLLSLNPACAA AL-----DNDDE-----------------------------------------------D DDDED------------------------------------------------------- ---------------------------------------------LPRFILCYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRAFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLFVEANMSPQ-KKGVRV SFRRLKKYDCKEKQDLVEKARENYRESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLHNEDT-G--EQMAVTSHAK-RISF--------QKILPDRMK PARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------DHLLGILKGTKKSKWLKSFLNAKSFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDQKMLTLIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IISSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGCR----ERELYDSKILFEKR---RRS------------- -------------------------------------------LAN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSCGRP00015025689 ------------------------------------------------------M--DG- EYVLCNWKEQLWPAKVLCRSEISSSS--KRKMAFSLKVQILSLDEKITVDSKDIKVLSKA EVETIVSLL---AVESEVRVPPREETAYERALKMALEIIRERSTQSQ-E----------- --------------------------NMPNEED--------------------------- --------------------------------------------------------TTVA ------------SE---SVPQQQDDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPP------ ------------------------------------------------------------ -----------------------------KKYRK-------------------------- ----------------------------------------------------------LE SNLQ------------E------------------------------------------- ---------------------------------------DSAS-ILLCSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLSDDKLQVRTAIESIASEME----------------------------------- ------------------------------------------------------------ ---------TKSSQNFSWCQTYSSFP-DD---EDD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKEE----------------- -------------------------------KIKIDMS---------------------- -ASMSMN---------LSIKEEAEDIKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FVPPS--------------------DDLTVP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------KEE-------------------------- ------------------------------------------------------------ -------AQE------------------IPLEAPTVSAECSIFPENNMEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNQ---------------- --------------------------------------------NPCFYGSQTQSSVESE IGAES------------------------------------------------ALPGCSG EYQVSLSACNPVNSDLLLQ----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------RLDLE----------- --------------------------------------DLE--E-EAR----A------- -----------------------------------------------SGKLLSLNPACAA AL-----DNDDE-----------------------------------------------D DDDED------------------------------------------------------- ---------------------------------------------LPRFILCYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRAFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLFVEANMSPQ-KKGVRV SFRRLKKYDCKEKQDLVEKARENYRESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLHNEDT-G--EQMAVTSHAK-RISF--------QKILPDRMK PARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------DHLLGILKGTKKSKWLKSFLNAKSFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDQKMLTLIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IISSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGCR----ERELYDSKILFEKR---RRS------------- -------------------------------------------LAN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSMAUP00000013562 ------------------------------------------------------M--DG- EYVLCNWKEQLWPAKVLYSSETLSNS--KRKKAFSLEVQILSLDEKITVDSKDVRVLSKS EVQTIVSLL---AVESEVRVPPREETAYERSLKMALEILKGRTTQSQ-E----------- --------------------------SMPNEEG--------------------------- --------------------------------------------------------TTVA ------------SE---RVPPKQSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPP------ ------------------------------------------------------------ -----------------------------KKYRK-------------------------- ----------------------------------------------------------LE SNLQ------------E------------------------------------------- ---------------------------------------DSAS-MLLCSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLSDDKLQVHTAIESIASENE----------------------------------- ------------------------------------------------------------ ---------TKASQNFSWCQTYPSFL-DD---EDD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKEE----------------- -------------------------------KKKVDIS---------------------- -AVMSMN---------LSLKEETEDIKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FVPPA--------------------EDLVVP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------KEE-------------------------- ------------------------------------------------------------ -------AQD------------------IPLQVPTVSSEFSTFPENDMEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNQ---------------- --------------------------------------------NPCFYGSQNQSSGESD IGPES------------------------------------------------SLAGCSG EYQVSLPACNPVNSDLLLQ----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------KLDLE----------- --------------------------------------DLE--E-EAR----A------- -----------------------------------------------SGKLLSLNPASAA AL-----DNDNE------------------------------------------------ DDDED------------------------------------------------------- ---------------------------------------------LPRFILCYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRAFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLMVEANMNPQ-KKGVRV SFRRLKKYDCKEKQALVEKAREEYRESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIINQDTFRNIFPKIHNEDT-G--EQMAVASHAK-RLSF--------QKILPDRMK PARDRANKNLVDFIVNAKGAE--------------------------------------- ------------------------NHLLGILKGTKKSKWLKSFLNAKSFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDQKMLTLIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYAAAEAKYLKGPS------------------------- -------------------LGYR----ERELYDSKIIFEKR---RRS------------- -------------------------------------------LAN-------------- -----------AQ----------------------------------------------- --S-------------------------------------------- >ENSPEMP00000029286 ------------------------------------------------------M--DG- EYVLCNWKEQLWPAIVLYRSESSSNS--KRKKTFSLEVQILSLDEKITVDSKDTKVLSKS EVEAIMSSL---AGQSEVRVPPREETAYERSLKMALEIVKERTHQIQ-E----------- --------------------------SMQDGED--------------------------- --------------------------------------------------------TTTA ------------SE---SVPQQLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPP------ ------------------------------------------------------------ -----------------------------KKYRK-------------------------- ----------------------------------------------------------LE SNLQ------------E------------------------------------------- ---------------------------------------DSAS-MLLCSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLSDDKLQVHTTSDSIPSEVE----------------------------------- ------------------------------------------------------------ ---------TKSSQNFSWCQTYPSFP-DD---DDD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKEE----------------- -------------------------------KKKIDIS---------------------- -AIMSVN---------LSLKEESEDIKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FVPSS--------------------DDLAVP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------KEESH------------------------ ---------------------DII------------------------------Y-SEVP AVSSECFA----------------------------------FPENNMEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNQ---------------- --------------------------------------------NPCLYGSQNQSSVESE VGAET------------------------------------------------SPAGCSG DNQVSLPACNPVNSDLLLQ----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------RLDLE----------- --------------------------------------DLE--E-EAR----A------- -----------------------------------------------SGKLLSLNPASSA AL-----DNDDD------------------------------------------------ DDDED------------------------------------------------------- ---------------------------------------------LPRFILCYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRAFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLFVEANMNPQ-KKGVRV SFRRLKKYDCKEKQALVEKAREEYSESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLHNEDT-G--EQMAVTSHAK-RISF--------QKILPDRMK PARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------DHLLGILKGTKKSKWLKSFLNAKSFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDQKMLTLIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGYR----ERELYDSKIIFEKR---RRS------------- -------------------------------------------LAN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSRNOP00000043912 ------------------------------------------------------M--DG- EYVLCSWKDQLWPAKVLDRSESPSDS--KRKKTLSVEVEILSLDEKITVESKDTKVLTKS AVEAIMSSL---TVQSEVSFTPTEETAYERSLKMALEIVEERTNQSH-E----------- --------------------------SMAEEQH--------------------------- --------------------------------------------------------MATA ------------SE---NVPQQPPDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKFRK-------------------------- ----------------------------------------------------------LE SNLQ------------E------------------------------------------- ---------------------------------------DSAS-MLLCSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLSDEKLQVHTTSENMPSEVE----------------------------------- ------------------------------------------------------------ ---------MK-SENLSCCQTYPSFS-DD----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKEE----------------- -------------------------------KKKIDIS---------------------- -AIMSVN---------LSLKEESEFIKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FVPSS--------------------EDLAVP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------KEESQ------------------------ ---------------------DIL------------------------------P--DAP AVSSECFI----------------------------------VSENNMEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNQ---------------- --------------------------------------------NPGSYGSQSQSTVESD VGAET------------------------------------------------STAGCSG DYQVSLPARDTVNSDLLLQ----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------RLDLE----------- --------------------------------------DLE--E-EAR----A------- -----------------------------------------------SGKLLSLNPACAA AL-----ENDDE------------------------------------------------ DDDED------------------------------------------------------- ---------------------------------------------LPRFILRYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRAFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLLVEADMNPQ-KRGVRV SLRRLKKYDCKEKQALVEKAREEYKESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLYNEDA-G--EQLPVASHAK-RVSF--------RKILPDRMK PARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------DHLLGILKGTKKSKWLKSFLNAKSFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDQKMLTLIKDDKIKFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGYR----ERELYDSKILFEKR---RRS------------- -------------------------------------------LPN-------------- -----------EG----------------------------------------------- --R-------------------------------------------- >ENSMUSP00000108666 ------------------------------------------------------M--DG- KYVLCNWKDQLWPAKVLDRSESPSES--KRKNTSSLEVEILSLDEKITVESTDTKVLSKS AVEAIMSSL---AVQSEVIIAPREETAYERSLKMALEMVKEGTNLSQ-E----------- --------------------------SMSEEQP--------------------------- --------------------------------------------------------TATA ------------SE---NVPEQPPDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKFRK-------------------------- ----------------------------------------------------------LE SNTQ------------E------------------------------------------- ---------------------------------------DSAS-ILLCSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SMTDDKLQVHTTGESMPSEMD----------------------------------- ------------------------------------------------------------ ---------TKATENLGCCQTDPSLA-DE----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKEE----------------- -------------------------------KKKIDIS---------------------- -AIMSVN---------LSLKEESEYIKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FVPSS--------------------EDLTVP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------KEESQ------------------------ ---------------------DIL------------------------------P-EAPL AVSSECSI----------------------------------VSENNMEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNQ---------------- --------------------------------------------NLVSYANQNQSSVESD VGAET------------------------------------------------STAGCSG DFQVSLPTRDTVSSDLLLQ----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------RLDLE----------- --------------------------------------DLE--E-EAR----A------- -----------------------------------------------SGKLLSLNPASAA AL-----ENDNE------------------------------------------------ DDDED------------------------------------------------------- ---------------------------------------------LPRFILHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRAFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLLVEADMSPQ-KKGVRV SLRRLKKYDCKEKQALVEKAREEYRESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLYNENV-G--EQLPMASQAK-RVSF--------QKILPDRMK PARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------DHLLGILKGTKKSKWLKSFLNAKSFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDQKMLTLIKDDKIKFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGCR----ERELYDSKILFEKR---RRS------------- -------------------------------------------LPN-------------- -----------EG----------------------------------------------- --H-------------------------------------------- >ENSMSIP00000014471 ------------------------------------------------------M--DG- KYVLCNWKDQLWPAKVLDRSESPSDS--KRKNTSSLEVEILSLDEKITVESTDTKVLTKS AVEAIMSSL---AVQSEVNVAPREETAYERSLKMALEMVKEGTNHSQ-E----------- --------------------------SMSEEQP--------------------------- --------------------------------------------------------TATA ------------SE---NVPEQPPDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKFRK-------------------------- ----------------------------------------------------------LE SNTQ------------E------------------------------------------- ---------------------------------------DSAS-ILLCSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SMTDDKLQVHTTGESMPSEMD----------------------------------- ------------------------------------------------------------ ---------TKATENLGCCQTDPSLA-DE----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKEE----------------- -------------------------------KKKIDIS---------------------- -AIMSVN---------LSLKEESEYIKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FVPSS--------------------EDLAVP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------KEESQ------------------------ ---------------------GIL------------------------------P-EAPL AVSSECSV----------------------------------VSENNMEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNQ---------------- --------------------------------------------NLVSYANQNQSSVESN VGAET------------------------------------------------SAAGCSG DFQVSLPTRDTVSSDLLLQ----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------RLDLE----------- --------------------------------------DLE--E-EAR----A------- -----------------------------------------------SGKLLSLNPASAA AL-----ENDNE------------------------------------------------ DDDED------------------------------------------------------- ---------------------------------------------LPRFILHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRAFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLLVEADMSPQ-KKGVRV SLRRLKKYDCKEKQALVEKAREEYRESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLYNENV-G--EQLPMASQAK-RVSF--------QKILPDRMK PARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------DHLLGILKGTKKSKWLKSFLSAKSFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDQKMLTLIKDDKIKFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGCR----ERELYDSKILFEKR---RRS------------- -------------------------------------------LPN-------------- -----------EG----------------------------------------------- --H-------------------------------------------- >MGP_SPRETEiJ_P0096572 ------------------------------------------------------M--DG- KYVLCNWKDQLWPAKVLDRSESPSDS--KRKITSSLEVEILSLDEKITVESTDTKVLTKS AVEAIMSSL---AVQSEVNVAPREETAYERSLKMALEMVKEGTNHNQ-E----------- --------------------------SMSEEQP--------------------------- --------------------------------------------------------TATA ------------SE---NVPEQPPDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKFRK-------------------------- ----------------------------------------------------------LE SNTQ------------E------------------------------------------- ---------------------------------------DSAS-ILLCSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SMTDDKLQVHTTGESMPSEMD----------------------------------- ------------------------------------------------------------ ---------TKATENLGCCQTDPSLA-DE----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKEE----------------- -------------------------------KKKIDIS---------------------- -AIMSVN---------LSLKEESEYIKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FVPSS--------------------EDLAVP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------KEESQ------------------------ ---------------------DIL------------------------------P-EAPL AVSSECSV----------------------------------VSENNMEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNQ---------------- --------------------------------------------NLVSYANQNQSSVESD VGAET------------------------------------------------STAGCSG DFQVSLPTRDTVSSDLLLQ----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------RLDLE----------- --------------------------------------DLE--E-EAR----A------- -----------------------------------------------SGKLLSLNPASAA AL-----ENDNE------------------------------------------------ DDDED------------------------------------------------------- ---------------------------------------------LPRFILHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRAFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLLVEADMSPQ-KKGVRV SLRRLKKYDCKEKQALVEKAREEYRESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLYNENV-G--EQLPMASQAK-RVSF--------QKILPDRMK PARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------DHLLGILKGTKKSKWLKSFLNAKSFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDQKMLTLIKDDKIKFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGCR----ERELYDSKILFEKR---RRS------------- -------------------------------------------LPN-------------- -----------EG----------------------------------------------- --H-------------------------------------------- >MGP_CAROLIEiJ_P0092809 ------------------------------------------------------M--DG- EYVLCNWKDQLWPAKVLDRSESPSDS--KRKNSSSLEVEILSLDEKITVESTDAKVLTKS AVEAIMSSL---AVQSEVNVAPREETAYERSLKMALEIVKEGTNHSQ-E----------- --------------------------SMSEEQP--------------------------- --------------------------------------------------------TATA ------------SE---NVPEQPPDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKFRK-------------------------- ----------------------------------------------------------LE SNTP------------E------------------------------------------- ---------------------------------------DSAS-ILLCSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SMTDDKLQVHTTGESMPSEMD----------------------------------- ------------------------------------------------------------ ---------TKASENLGCCQTDPSLA-VE----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKEE----------------- -------------------------------KKKIDIS---------------------- -AIMSVN---------LSLKEESEYIKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FVPSS--------------------EDLAVP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------KEESQ------------------------ ---------------------DIL------------------------------P-EAPP AVSSECSA----------------------------------VSENNMEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNQ---------------- --------------------------------------------NLVSYANQNQSSVESD VGAET------------------------------------------------STAGCSG DFQVSLPARDTVSSDLLLQ----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------RLDLE----------- --------------------------------------DLE--E-EAR----A------- -----------------------------------------------SGKLLSLNPASAA AL-----ENDNE------------------------------------------------ DDDED------------------------------------------------------- ---------------------------------------------LPRFILHYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRAFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLLVEADMSPQ-KKGVRV SLRRLKKYDCKEKQALVEKAREEYRESIDWCISLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLYNENV-G--EQLPMASQAK-RVSF--------QKILPDRMK PARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------DHLLGILKGTKKSKWLKSFLNAKSFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDQKMLTLIKDDKIKFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGCR----ERELYDSKILFEKR---RRS------------- -------------------------------------------LPN-------------- -----------EG----------------------------------------------- --R-------------------------------------------- >MGP_PahariEiJ_P0090419 ------------------------------------------------------M--DG- EYVLCNWKGQLWPAKVLDKSESPSDS--KRKNTPSLKVEILSLDEKITMESTDTKVLTKS AVEAIMSSL---AVQSEVNLAPREETTYERSLKMALEIVKGRTNQSQ-E----------- --------------------------STSEEQH--------------------------- --------------------------------------------------------TATA ------------SE---NVGEQPPDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPQ------ ------------------------------------------------------------ -----------------------------KKFRK-------------------------- ----------------------------------------------------------LE SNIQ------------E------------------------------------------- ---------------------------------------DSAS-ILLCSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SMTDDKLQVHTTSESTPSEME----------------------------------- ------------------------------------------------------------ ---------TKASENIGCCQTYPSFS-DD----DD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKEE----------------- -------------------------------KKKIDIS---------------------- -AIMSAN---------LSLKEESEYIKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FVPSS--------------------EDLAVP-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------KEESQ------------------------ ---------------------DIL------------------------------L-EDPP AVSSECSA----------------------------------VSENNMEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNQ---------------- --------------------------------------------NPSSYANQNQSSVEPD VGAEI------------------------------------------------STAGCSG DFQVSLPARDTVNSDLLLQ----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------RLDLE----------- --------------------------------------DLE--E-EAR----A------- -----------------------------------------------SGKLLSLNPASAA AL-----ENDDE------------------------------------------------ DDDED------------------------------------------------------- ---------------------------------------------LPRFILRYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRAFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLLVEADMSPQ-KKGVRV SLRRLKKYDCKEKQALVEKAREEYRESINWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLYNENT-G--EHLPVASHAK-RVSF--------QKILPDRMK PARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------DHLLGILKGTKKSKWLKSFLNAKSFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDQKMLTRIKDDKIKFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGCR----ERELYDSKILFEKR---RRS------------- -------------------------------------------LPN-------------- -----------EG----------------------------------------------- --R-------------------------------------------- >ENSMUGP00000028818 ------------------------------------------------------M--DN- EYVLCNWKDQLWPAKVLYRCTTPLGS--KKKKTFSLGVQILALDEKITVDSKDTRALSEC EVKAIVSSL---AVQSEVKVPPREETVYERSLKMALEIVKERTNQSQ-E----------- --------------------------SISDEAH--------------------------- --------------------------------------------------------TSTA ------------AE---NVIKQPPDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKFRR-------------------------- ----------------------------------------------------------LK RKFQ------------E------------------------------------------- ---------------------------------------DSAF-MLLCSESD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------D------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLPDDKTQVHTRSQSMSSEME----------------------------------- ------------------------------------------------------------ ---------TKSSQNLSWSQTYSSFT-DD---ED-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ED----------------- -------------------------------KKKFDIS---------------------- -TVVSLN---------SSLKEENDYIKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FSPPS--------------------EDLAVL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------KEESQ------------------------ ---------------------DIY------------------------------P--DVP AVSSECVT----------------------------------SSENNVEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNQ---------------- --------------------------------------------NPCFYASQSQSSVESE IGAET------------------------------------------------SAAGCSG ECQVSLPAYNPVNSDLLIQ----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------RLDLE----------- --------------------------------------DLE--E-EAR----D------- -----------------------------------------------SGKLLSLHPALEA AL-----ENDD------------------------------------------------- DEDED------------------------------------------------------- ---------------------------------------------LPRFILCYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRAFETGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLLVEANMNPQ-KKGVRV SLRRLKKYDCKEKQELVEKAREEYRESIDWCVSLICDYRVRLGCRSFTGSFFEYYAADIS YPVRKLIKQDTFRNIFPKLYNEDT-R--GQLPVTSHTK-RMSF--------QKILPDRMK PARDRANKNLVDFIVNAKGTE--------------------------------------- ------------------------DHLLSILKGTKKSKWLKAFLHAKSFTPCIETYFEDE EQLDEIVKYLQEI-Y-KKIDQKMLTLIKDDKIKFILEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISAVDGLDYEAAEAKYLKGPS------------------------- -------------------LGYR----ERELYDSKIISGKR---RQS------------- -------------------------------------------LRN-------------- -----------EA----------------------------------------------- --H-------------------------------------------- >ENSNGAP00000008556 ------------------------------------------------------M--DA- EYVLCNWKDQLWPAKVLSRSETSSNT--KKKMTFSLEVQILSLDEKITVDSTEAKVLSKS EIETIMSSL---AVQSEVRALPREETAYERSLKAALEILKERTTLSE-E----------- --------------------------RMSDEEE--------------------------- --------------------------------------------------------TTAL ------------SE---NVPQNLSDS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPH------ ------------------------------------------------------------ -----------------------------KKYRKQEGN---------------------- -----------------------------------------VYKDPTPVFISSPNNDC-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----LSDDKSQLHTTTDGISNEME----------------------------------- ------------------------------------------------------------ ---------TKSSQNFSLCQSYPSLS-DD---DDD------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KKEE----------------- -------------------------------KKKIEIS---------------------- -AVSSVN---------FSFKEESDYVKEEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---YTPSS--------------------DGLRVP-------------------------- ------------------------------------------------------------ -------------------------KA--------------------------------- ------------------------------------------------------------ ------------------------------VKEEEQ------------------------ ---------------------DDH------------------------------P--HVP AMSSECST----------------------------------FSENNMEDPGE------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GPSNV---------------- --------------------------------------------NPCTYASQNQSSVESD VGAEI------------------------------------------------SPAGCSG EYQVSLPASHPVHSDFLRQ----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------RLDLE----------- --------------------------------------DLD--E-EAR----A------- -----------------------------------------------SGKLLELNPVTAA AL-----ENDEN------------------------------------------------ EDDEE------------------------------------------------------- ---------------------------------------------LPRFILCYE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRAFEEGMIVWFKYQKYPFWPAV------ ------------------------------IKSIRRKERKASVLFVEANMNPQ-KKGVRV SFRQLKKYDCKEKQALVEKAREEYRDSIDWCISLICDYRVRLGCGSFSGTFFEYYAADIS YPVRKIIKQDTFRNIFPKLYDEDT-M--EPMTVASHTK-RMTF--------QKILPDRMK PARDRANRNLVNFIVNAKGTE--------------------------------------- ------------------------DHLLGILKGTKKSKWLKSFLNAKSFTPCIETYFEDE DQLDEVVKYLQEI-Y-KQIDPKMLIQIKNDKIKFIMEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSISFVDGLDYETAEAKYLKGPS------------------------- -------------------LGYR----ERELYDSKIIFEKR---RRS------------- -------------------------------------------LAN-------------- -----------EV----------------------------------------------- --Q-------------------------------------------- >ENSOCUP00000009209 ------------------------------------------------------M--VA- KYILCDWRGHLWPAKVLSRRGPSAKA--KRKRALLLAVQILGVDEKIRVKRADVKALTTS DLEAVAFSA---RTMPKGSMPLGQKRGYRRALRAAWEMLRKRESWGQ-E----------- --------------------------Q--------------------------------- -------------------------------------------------KA--------- -----------------KVPKALA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPQ------ ------------------------------KTRQKPGCPL-------------------- ---------------------------ARKRHRKPRRA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LWTR-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------RKKSKR---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------PGP------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------E------- ------------------------------------------------------------ --------------------------------P--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------GPMPSESE----------------------------------- ----------------------------------------------DAFLLGEKLQEPMS AAPPAAAVQTEAPHSSSVGQKVPTLA---------------------------------- -----------------------------------------------SP----------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------RKRK------------------------- ------------------------------------------------------------ ---------------------------------------AKEK----------------- ---------------------PKGK------RGKAGTS---------------------- -AVACLT---------PTVVEEGAGATQDQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---GVPSQPLGL-------------PRAE------------------------------- ------------------------------------------------------------ -----------------------P-RA--------------------------------- ------------------------------------------------------------ ------------------------------VYREAE------------------------ ---------------------DSC------------------------------P--TTQ ATSSECSV----------------------------------STE-RTEDSGEDTSEAVS QAARVPFKDRLPKLQIVFRT-----------------PKRRKKLRKAARDKGPPKSRGKT GKK----GG-----------------------EGRVTG--LLTP---------GEKRSNK KQRLVD---------KGPAKVPR------KSGRK--EEEGPA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TSDTALQETRATKKRRLDDRTRPEIRGTYKKGEEEPS----------- --------------------------------TSSAAPRATPRIKKGRPPRKRPRKIPGK AGRNEEDELASMFMALHMSPPTETQQLVNKPLSKVPRKGGRRAEEGAPTTLVTLQDTQPA EKPRLEDIEPPKISGEPY------------RKEEGP------------------------ ------------HASIVT---HQE------------------------------PPPTEK LRLADEGLPKVHEKSDRKGEEGAPSSFVAPQEMNSIEKARLIDKEPPSIHCKTDSKGEEE PST----SFAAS----------------------------QETP---------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PIDTG RL-------DDKEMSVVPQKGY-------------------------------------- REEEERPDVSVVALHDTCPTEKQKVVDKGMPKICRKSKKKAGEGISTSFAAIRDSPPAKK KRVVDKGLSKDPRKGVRKEEEGPATSILTLQESPPIEKLRQVVKVLPKVHWTYSKEEEEE STSLAARQQYPLTETGGLIDKGPPKVPGMSDRKEEEGPTTSTVTLQESHIAEKQRLVEKL FPKLYWKSDGEAGEGPSTSFAAPQDVSPAKKRRLVEKGLSKKSGRNGGEGPSTSLAALQD SPPANKQRLVDRESPKTPKKAIRKGEKGPATPSPIGKGALVWFKFQEHPYWPAV------ ------------------------------VKSVSETDKTARVFLIEASLCPE-KRGIRV PLARLKHLDCAGKDKFLKTARKAYPEGVNWVFSLITHYRKQLGRGSFVGSFLNYYTADVS YRIRRVIQDSELDITFPKVDYTEL-EALEDSEETALQG-MPSH--------KKILPDRTK AAWDRDNQKLVDFIVKKKGAD--------------------------------------- ------------------------SHLLAILKGKKQSRWLRSFLNSHQYVVCVETYLEDE DQLELVTKHLQQV-Y-EHIDQRLQALVR-DKVKFVLEVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICSIAALDGLEYKDAEKKYLQGPP------------------------- -------------------VHYR----EKELFDKNSLKRVR---RRL------------- -------------------------------------------AST-------------- ----------CAA-------------SSSLGAPG-PQHAAS------------------S SSQ-------------------------------------------- >ENSSCAP00000008420 ------------------------------------------------------MT-DQ- EFILCKWKRRLWPAKVLCKPGVAGSSPDATPKRMGFKAEILGLEKQVSVSSANVVPLTEE RIKAIASTL----EQKKTMSEAVEELQYRCSLKIALDILQETDSSSQ-MP---------- ---------------------------PA-EGPNPEF----------------------- ------------------------------------------------------------ ------------SR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------EKSA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPT------ ---------------PS--------HGFLLRSR------------SKKSEHEAA------ -----------------------------KRKRKPQNNC--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ELKD------------------DPKA----------------- ------------------------------------------------------------ ----------RSQG-GSVAPG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------RSGKA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------PGS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GTSP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ARYGARDSSVAPAPDSHNCKKPEP--KSS PRQKKIQPK------MGNGVS-CKSE---------------------------------- ---------------------------AGR------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SQQG----------------- ------------------------------------------------------------ ------------------------------------------------------------ RK-R--------CRDDSPQDQAQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---VAP------------------------------------------------------ ----------------------------------EEGSPSVSSKSGTMEPSRKKGT---- ------------------------------------------------------------ -------------------------------------------------------Q---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------GRAFLDSSCETASDELEKSI-------------SSE--------------- --------------------------SESLAKQL-------------------------- -------DGRREAEGGKH------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PDGA--------- ----------------------------AVASGTDRKCRNH------------------- ------------------------------------------------------------ -------------------------------------------------S---------- ------------------------------------------------------------ ------------------------------GSSPGP--------------S-------GA FPQP--P--------------EEE------------------------------------ ------------------------------------------NQDPSH------------ --------------------LAGNKA---------------------------------- ---------------------------------------------PDSE----------- -------------------------------------------E-D-E-GLEPSGMSSRR VSSESLPPLS-------------------------------------------------P LA-----D---------------------------------------------------- EEEEN------------------------------------------------------- ---------------------------------------------FPSVLSHRE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PKFFEEGMLVWCKLRRYPYWPAV------ ------------------------------VKAVKRKHRRACVLFIDGTTNEK-KKGFSV SLKSLKHLDCEEKQELIERAKENYSREIEWCLQLIQDYRIRVGCRSFTGSFLEYFAADIS YPVRKQGYQSVVQMAFPNTGEEGA-G--ESSSDTSP---QKPP--------RKLLPDRTR AARDRENKKLVEFIVKTKGAE--------------------------------------- ------------------------EHLLGILKSGKQSRWLKKFLNSSRYITCVETYLEDE EQLDLVVGYLKEV-Y-REMDTKNLHQILGDGIRFISDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAIAAVDDIDYEKAEEKYIKGPP------------------------- -------------------VSKR----ERELFDEQVLGSKK---LKT------------- -----------------------------------------EAEPA-------------- -----------ES----------------------------------------------- ----------------------------------------------- >ENSJHYP00000003344 ------------------------------------------------------MT-DQ- EFVLCKWKRRLWPAKVLCKPGVAGSSPVATTKKMGFKAEILGLEKQVSVSSANVVPLTEE RIKAIASTL----EQKKTMSEAVEELQYRCSLKIALDILHETDSSTQ-MP---------- ---------------------------LA-EGPNPEF----------------------- ------------------------------------------------------------ ------------SR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------EKSA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPT------ ---------------PS--------HSFSLRSR------------WKKSEPEAA------ -----------------------------KRKRKAQNNS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------GMKD------------------DPKA----------------- ------------------------------------------------------------ ----------RSQG-GSVAPG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------RSGKA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------PGG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GTNP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ARCGARDSSVAPAPDGHNCEKPEP--KSS PRQRKMQPK------MENGVS-CKAE---------------------------------- ---------------------------VGR------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------NQQG----------------- ------------------------------------------------------------ ------------------------------------------------------------ RKRR--------WRDDSIQDQTQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---VAP------------------------------------------------------ ----------------------------------EEGSPSVPSKSGTMEPSRKKGA---- ------------------------------------------------------------ -------------------------------------------------------R---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------GRAFLDSCSETASDELEKSI-------------SSE--------------- --------------------------SESLAKQL-------------------------- -------DGRREAEGGKH------------------------------------------ ------------------------------------------------------------ -----------------------------------------------PDGA--------- ----------------------------------ERKCRNH------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ------------------------------------------------------------ ------------------------------GSSPGP--------------S-------GA LPQP--Q--------------EQE------------------------------------ ------------------------------------------NQDPSH------------ --------------------LPGNKA---------------------------------- ---------------------------------------------PDSE----------- -------------------------------------------E-D-E-GLEASGMSSRR VSLESLPPLS-------------------------------------------------P LT-----D---------------------------------------------------- EEEEN------------------------------------------------------- ---------------------------------------------LPSVLSYRE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PKFFEEGMLVWCKLRRYPYWPAV------ ------------------------------VKAVKRKHRRACVLFIDGTTNEK-KKGFSV SLKSLKHFDCEEKQELIERAKENYCREIKWCLHLIQDYRIRVGCRSFTGSFLEYFAADIS YPVRKEGYQSVVQMAFPNTGEEGA-G--ESSSDTSP---QKPP--------RRLLPDRTR AARDRENKKLVEFIVKSKGAE--------------------------------------- ------------------------EHLLGILKSGKQSRWLKKFLNSRRYVTCVETYLEDE EQLDLVVGYLKEV-Y-REMDTKNLRQILGDGITFISNVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAIAAVDDIDYEKAEEKYIKGPP------------------------- -------------------VSKR----EKELFDEQVLGSKK---LKT------------- -----------------------------------------EPEPA-------------- -----------ES----------------------------------------------- ----------------------------------------------- >ENSCCEP00000001778 ------------------------------------------------------MT-DQ- ELVLCKWKRRLWPAKVLCKPGVAGSSPVATTKRMGFKAEIFGLEKQVSVSSANVVPLTEE RIKAIASTL----EQKNSMSEAVEELQYRCSLKIALDILHQTDSGSQ-IP---------- ---------------------------PA-EGPNSEF----------------------- ------------------------------------------------------------ ------------SQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------EKSA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPA------ ---------------PS--------HGFLLRSR------------SKKSEPEAA------ -----------------------------KRKRKPQNNC--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------GLKD------------------DPKA----------------- ------------------------------------------------------------ ----------RSQG-GSVAPE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GSGKA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------PGSG-----TNP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------SRAPGSGTSP--------------------------------------- ----------------------ARTRGG-GTNP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ARCGARDSSVPPAPDGHSCEKPES--KSS PSQRKIQPK------TGNGVS-CMPK---------------------------------- ---------------------------AGR------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SQQG----------------- ------------------------------------------------------------ ------------------------------------------------------------ RKRG--------CRDDSPE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---VAP------------------------------------------------------ ----------------------------------EEGSPPVLSKSGTVEPPEKTGA---- ------------------------------------------------------------ -------------------------------------------------------Q---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------GRAFLDSSCGTASDELEKSI-------------SSE--------------- --------------------------SESLAKQL-------------------------- -------DGRREEEAGKQ------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LDGA--------- ----------------------------GVASGTDRKCRSH------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ------------------------------------------------------------ ------------------------------GSSPGP--------------S-------GA FPQPQ-E--------------EEE------------------------------------ ------------------------------------------NQDPSH------------ --------------------LAGNKA---------------------------------- ---------------------------------------------PDSE----------- -------------------------------------------E-D-E-GLEPSGMSSRR SSSESLPPLS-------------------------------------------------P LA-----D---------------------------------------------------- EEEEN------------------------------------------------------- ---------------------------------------------FPSVLSHRE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PKFFQEGMLVWCKLQRYPYWPAV------ ------------------------------VKAVKRKHRRACVLFIDGTTNEK-KKGFSV SLKSLKHFDCEEKQELIERAKENYSREIEWCLQLILDYRIRVGCHSFTGSFLEYFAADIS YPVRKEGYQSVVQMAFPNTEGEGA-G--ESSSDTSP---QKPP--------RKLLPDRTR AARDRENKKLVEFIVKSKGAE--------------------------------------- ------------------------EHLLGILKSGKQSRWLKKFLNSSRYMTCVETYLEDE EQLDLVVGYLKEV-Y-REMDTKNLHQILGDGIRFISDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAIAAVDDIDYEKAEEKYIKGPP------------------------- -------------------VSKR----ERELFDEQVLGSKK---LKT------------- -----------------------------------------EPEPA-------------- -----------ES----------------------------------------------- ----------------------------------------------- >ENSPMJP00000015387 ------------------------------------------------------MT-DQ- EFVLCKWKRRLWPAKVLCKPGVTGGSPVATTKRMGFKAEILGLEKQVSVSSANVVPLTEE RIKAIASTL----EQKKSMSEAVEELQYRCSLKIALDILHQTDSGSQ-TP---------- ---------------------------PA-EGPNSEF----------------------- ------------------------------------------------------------ ------------SQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------EKSA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PPA------ ---------------PS--------HGFLLRSR------------SKKSEPEAA------ -----------------------------KRKRKPQNNC--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------GLKD------------------DAKW----------------- ------------------------------------------------------------ ----------QSQG-GSVAPE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GSGKA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------PGSG-----TNP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------SRAPGSGTSP--------------------------------------- ----------------------ARTRGG-GTNP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ARCGARDSRVPPAPDGHNCEKPES--KSS PSQRKIQPK------TGNGVS-CMPK---------------------------------- ---------------------------AGR------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SQQG----------------- ------------------------------------------------------------ ------------------------------------------------------------ RKRG--------CRDDSPQDQAR------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---VAP------------------------------------------------------ ----------------------------------EEGSPPVLSKSGTVEPPGKTGA---- ------------------------------------------------------------ -------------------------------------------------------Q---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------GRAFLDSSCGTASDELEKSI-------------SSE--------------- --------------------------SESLAKQL-------------------------- -------DGRREEEAGKH------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LDGA--------- ----------------------------GVASGTDRKCRSH------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ------------------------------------------------------------ ------------------------------GSSPGP--------------S-------GA FPQPQEE--------------EEE------------------------------------ ------------------------------------------NQDPSH------------ --------------------LAGNKA---------------------------------- ---------------------------------------------PDSE----------- -------------------------------------------E-D-E-GLESSGMSSRR FSSESLPPLS-------------------------------------------------P LA-----D---------------------------------------------------- EEEEN------------------------------------------------------- ---------------------------------------------FPSVLSHRE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PKFFEEGMLVWCKLQRYPYWPAV------ ------------------------------VKAVKRKHRRACVLFIDGTTNEK-KKGFSV SLKSLKHFDCEEKQELIERAKENYSREIEWCLQLILDYRIRVGCHSFTGSFLEYFAADIS YPVRKEGYQSVVQMAFPNTEGEGA-G--ESSSDTSP---QKPP--------RKLLPDRTR AARDRENKKLVEFIVKSKGAE--------------------------------------- ------------------------EHLLGILKSGKQSRWLKKFLNSSRYMTCVETYLEDE EQLDLVVGYLKEV-Y-REMDTKNLHQILGDGIRFISDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IICAIAAVDDIDYEKAEEKYIKGPP------------------------- -------------------VSKR----ERELFDEQVLGSKK---LKT------------- -----------------------------------------EPEPA-------------- -----------ES----------------------------------------------- ----------------------------------------------- >ENSMVIP00005021933 ------------------------------------------------------MA-DP- EFVLCKWKRRLWPAKVLCKAGVAGSTHVGTTAKMGFKAEILGLEKQVSVSSADAVPLTEE RIKAIASSL----EQKNNVSEAVEELQYRCSLKIALDILTQTGSGRQ-AP---------- ---------------------------PA-EGPDPEL----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PQDRSVGSPPATPPGSSLWRSRSAKLQPEAARGKRDPERN CNLRSATRTRLLGGSLPSG-HSAKARGA-GINP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------SRCGPRELRDAPAPASHNCKVPRP--KSS PRQRKVQPK------PGSKAS-LKAK---------------------------------- ---------------------------EGR------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SQQG----------------- ------------------------------------------------------------ ------------------------------------------------------------ RKRS--------CRDDSPQDQAQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---LPP------------------------------------------------------ ----------------------------------EEGSLPVPSKSGTVEPAQRTGT---- ------------------------------------------------------------ -------------------------------------------------------Q---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------GRTFLDSSGERASDELEKSI-------------SSE--------------- --------------------------SESLAKQL-------------------------- -------DGRRKAEGGKQ------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LDGA--------- ----------------------------GVASGRDRKCRNH------------------- ------------------------------------------------------------ -------------------------------------------------S---------- ------------------------------------------------------------ ------------------------------GSSPGP--------------S-------GA FPQP--Q--------------EQE------------------------------------ ------------------------------------------NKEPSP------------ --------------------LAGNKAKQLQ------------------------------ --------------------------------------------LPDSE----------- -------------------------------------------E-D-E-GLDPSGMSSRA VSSESFPPLS-------------------------------------------------P LA-----D---------------------------------------------------- EEEED------------------------------------------------------- ---------------------------------------------FPCVLSCQV------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PQSIEEGMLVWCKFRRYPYWPAV------ ------------------------------VKTVKRKPRRACVLFIDGTTNEK-KKGFSV SLKTLKHFDCEEKQELIDRAKENYPQEIEWCLQLIRDYWVRVGCHSFTGSFLEYLAADIS YPVRKQGHQGEVEMTFPSTAEEDL-G--ESSLENSP---QKPL--------RRLLPDRSR AARDRENKKLVEFIVKTKGAE--------------------------------------- ------------------------EHLRGILKSGKKSRWLKKFLNSYWYVTRVETYLEDE EQLELVFDYLKEV-Y-REMDTTNLRQILGDGIKFISDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYAIAAVYDIDYKKAEEKYIKGPP------------------------- -------------------VTKR----ERELFDEQIRAWKK---LKS------------- -----------------------------------------TLEPE-------------- -----------ES----------------------------------------------- ----------------------------------------------- >ENSGALP00000015790 ------------------------------------------------------MA-KR- GYILCGWRERLWPAKVL--PKLAEEPPITGAQEETLEVEIIGLKERVSVKQEDAVPLEEA CIEDIVSNL----NEKADPNEAVEELKYRCALKTALDYLKEDVSARE-AP---------- ---------------------------PSKEGPSTRL----------------------- ------------------------------------------------------------ ------------SQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ASSAR-------------- ----------------SLSSST-------------------------------------- -----------------------------------------------------------L TSFQSLP----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------KEKLESESL------ -----------------------------NRKRKQRN----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SPSLR TGTKKRNLRCSLILEKSPEANENGTEPSKCSTG--------------------------- ------------------------------------------------------------ ----------------------------------------------------D------- -----LCNTSNS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------DSENCMATGS--SLL AGEKKTKPKLLKKSLTSNKLS-LKLK---------------------------------- ---------------------------EEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SKQG----------------- ------------------------------------------------------------ ------------------------------------------------------------ RRRAKGAGSPG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---SLPNGSSKGRGRP---------PA--------------------------------- ----------------------EGASLSASC--------SSGTVVAGRSRMSTRLQ---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------KGMLLRSSSKSAS-VLEKST-------------GSE--------------- --------------------------NKNVAKQV-------------------------- -------NGRKKTRSLKQPK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------GKQETNA------TTSSYRKRECRNS------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ------------------------------------------------------------ ------------------------------ESSAGL--------------SDCRVLSDGI LSQL--Q--------------EEE------------------------------------ ------------------------------------------NEAVPP------------ --------------------VVVNKAKEFH------------------------------ --------------------------------------------LPDFE----------- -------------------------------------------E-E-E-GLEPSGLSSER TFSEKLSQLS-------------------------------------------------D LV-------DED------------------------------------------------ DDEEE------------------------------------------------------- ---------------------------------------------LPSILSHQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PESIDKGILVWCKWQRYPYWPAV------ ------------------------------VKNVKRKHRKANVLFIEGDTSDK-KKSFSV SLRNLKHFDCEEKQDLIDQAKKDYCQEIEWCIQLISDYRIRVGCHSFTGSFLEYFADDIS YPVRKQYQQSSVQMTFPSVAEEDL-E--DSLLETSP---QKPS--------RKLLPDRTR AARDKANKKIVEFIVKTKGAE--------------------------------------- ------------------------EHLLAILKCRKESRWMKDFLSSRQYGTCIETYLEDE EQLELVVNYLKEVAY-HEIDTAHLHRLRGDGVKFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYAISAVDDIDYKKAEEKYMKGPS------------------------- -------------------VSKR----EREEFDEEILERKR---LQA------------- -----------------------------------------ELVAA-------------- -----------DS----------------------------------------------- --V-------------------------------------------- >ENSNMEP00000002659 MSNKVSSQGTHPGGNCNQKKKKKEFVSSVNKVLFQDYLYLESVLEFSFPTRGAGMA-NR- GYVLCSWRERLWPAKVLLKPGLAEEPSVTNTQ-ETLEVEIVGLKEKISVKQADAVPLEEA RIEDIVSNL----NEKKDPNEAVEELKYRCALKTALDSLKENVPARQ-VP---------- ---------------------------PSKEGPSTRL----------------------- ------------------------------------------------------------ ------------SQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ANKAR-------------- ----------------SLSSSP-------------------------------------- -----------------------------------------------------------F TGRQSLS----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------KEKLKSETP------ -----------------------------SRKRKQRN----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SPSLK TGTRSQNLKCSFIPEESPGANENGTKPSKRSTG--------------------------- ------------------------------------------------------------ ----------------------------------------------------D------- -----LCNTSDL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GSQNCTVTGS--PLL SREKKLKPRLLKKSLTSNKLS-LKPK---------------------------------- ---------------------------EEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SKRG----------------- ------------------------------------------------------------ ------------------------------------------------------------ RKRARGAGSPV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---SLTNGSPKEQGQP---------PA--------------------------------- ----------------------EGASLSASC--------NAGPVGPERSRMSTRQQ---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------KKMVLCSSSRNTS-VLEKST-------------GSE--------------- --------------------------AKNGAKQV-------------------------- -------NGRKRTRSLKQLR---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------GKRETSA------TVSSHRKRGCRNG------------------- ------------------------------------------------------------ -------------------------------------------------PRP-------- ------------------------------------------------------------ ----------------PAGLSDGFPSQLQEE----------------------------- ---------------------EEE------------------------------------ ------------------------------------------NEDVPP------------ --------------------VVMNQAKEFH------------------------------ --------------------------------------------LPDFE----------- -------------------------------------------E-E-E-GLEPSGLSSEQ VFSEKLSQLS-------------------------------------------------D LV-------DDD------------------------------------------------ DDEEE------------------------------------------------------- ---------------------------------------------LPSILSHQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PESIDEGILVWCKWQRYPYWPAV------ ------------------------------VKNVKRKHRKANVFFIEGNTGDK-KRSFSV SLRNLKHFDCEEKQDLIDQAKKDYRQEIEWCIQLISDYRIRVGCHSFTGSFLEYFADDIS YPVRKQYRQSFVEMTFPNGAEEDL-E--ESALETSP---QKPS--------RKLLPDRTR AARDKANKKIVEFIVKTKGAE--------------------------------------- ------------------------EHLLAILKCRKESRWMKDFLSSRQYGSCVETYLEDE EQLDLVVNYLKEVAC-HEGDTANLQRLHGDGVKFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYAISAVDDIDYKKAEEKYMKGPS------------------------- -------------------VSKR----EREKFDEEILERRW---LQS------------- -----------------------------------------ELVAA-------------- -----------DS----------------------------------------------- --V-------------------------------------------- >ENSCJPP00005012543 ------------------------------------------------------MA-SG- GYVLYRWKERLWPAKVLPKAGLAEEPPIANAQ-ETLEIEIIGLKERVSVKQEDAVPLEEA RIEDIVSNL----SEKVDPIEAVEELKYRCALKYALDSLKEDVATLE-VS---------- ---------------------------PSKEGPSTRL----------------------- ------------------------------------------------------------ ------------SQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ANSAR-------------- ----------------SLSSSP-------------------------------------- -----------------------------------------------------------L TRCQSLS----------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------KEQLESESL------ -----------------------------NRKRKQRN----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SPDLR TEKKKQNLGCSLSLEERPGVNENGTNPSKCGNG--------------------------- ------------------------------------------------------------ ----------------------------------------------------D------- -----LCNTSKS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GSENCMAMGS--PMA LRGKKPEPKVLKKSLTSNKPS-LKLK---------------------------------- ---------------------------EER------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------NKQG----------------- ------------------------------------------------------------ ------------------------------------------------------------ RERARGAGSPG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---SLTNGSSKGQGQT---------PA--------------------------------- ----------------------GGAALSAAC--------SS--VLSERSRMSTRQQ---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------KGMALRSASKSAS-VLEKNT-------------GSE--------------- --------------------------SRNVGKQ--------------------------- ------------TRNLKGLK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------GEQETNT------TTSSCRERECTNS------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ------------------------------------------------------------ ------------------------------ESSAGL--------------SDCTVLSDGV LSQL-----------------QEE------------------------------------ ------------------------------------------NEDEPP------------ --------------------VVMDKAKEFH------------------------------ --------------------------------------------LPDFE----------- -------------------------------------------E-E-E-GLKPSGLSSER TLSEKLSHLS-------------------------------------------------D LV-----D-DDD------------------------------------------------ DDEEE------------------------------------------------------- ---------------------------------------------LPSILSHQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PESIDKGILVWCKWQKFPYLPAV------ ------------------------------VTNVKRKYRKAYVLFIEENMSDKNNKSLSV SLRNLKHFDCKEKQDLIDQAKKDYRQEIEWCIQLISDYRIRVGCHSFTGSFLEYFADDIS CPVKKQYQLSSAQMTFPSIAEEDL-E--DSVLETSP---QKPS--------RKLLPDRTR AARDKANQKIVEFIVKTKGAE--------------------------------------- ------------------------EHLLAILKCRKESRWMKDFLSSRQHGTCIETYLEDE EQLELVVNYLKEVAY-HEIDTSNLQQLLGDGVKFISDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYAISAVDDIDYKEAEEKYMKGPS------------------------- -------------------VSKR----EREEFDEEILERKR---LQA------------- -----------------------------------------QPVAA-------------- -----------DS----------------------------------------------- --V-------------------------------------------- >ENSCPUP00000024111 ------------------------------------------------------MT-DQ- EYVLCTWKKRLWPAKVLCKTGAGGKTSIKNAKETSFKVEILGLKKQISVSRADAVPLKEE CIENIASSL----DQRNNSSEAVEELRYRCSLKIALDILNQNISPRE-VP---------- ---------------------------PSERLKS-QL----------------------- ------------------------------------------------------------ ------------SR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ENDAG-------------- ----------------SLSSTP-------------------------------------- -----------------------------------------------------------L RRCRLFCHSKEESVPETSKK---------------KREQK-------------------- ------------------------------------------NASLKTDAKP-------- ------------------------------QTRD------TSFL---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LEEGAKAHEKGTNTTTC------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------NTSHS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------DNQNCKTPDS--KPL PGQKKMKPALLTKSQTGNKDP-LTPK---------------------------------- ---------------------------EEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SEQG----------------- ------------------------------------------------------------ ------------------------------------------------------------ RKS--------------------------------------------------------- ----------------------------------RRDA---------------------- ------------------------------------------------------------ ---VSPLS-----------------------RMN-RFP---------------------- --------------------------GDAAQPRAEEGSP----------------LPVPC EGVPL------------------------------------------------------- ------------------------------------------------KRANTRSQ---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------RRTLLASSCKSASDDLEKSI-------------SSE--------------- --------------------------SESLAKQL-------------------------- -------GGRRQPAGLKR------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------VNGEQETLSSCRKRRCRNG------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ------------------------------------------------------------ ------------------------------ESSSGP--------------S--------- -------ICELRSESVPSQREEQE------------------------------------ ------------------------------------------NKNISH------------ --------------------PVTDKVTAFQ------------------------------ --------------------------------------------LPDFE----------- -------------------------------------------E-D-E-GLESSDLSPKI VYPESLSRLS-------------------------------------------------A LV-----D-EEE------------------------------------------------ DEDEE------------------------------------------------------- ---------------------------------------------LPSILSNQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PQSIEEGMLVWYKLRRYPHWPAV------ ------------------------------VKKVKRKRRKACVLFIEGSTNDK-KKGFSV SLRSLKHFDCEEKQDLIERAKEDYRQEIEWCIRLISDYRIRVGCRSFTGSFLEYFAADIS YPVRKECCQGLVPMSFPNVAEENI-E--ESSSETSP---QKPS--------KKLLPDRTR AARDKANKKIVEFIVKTKGAE--------------------------------------- ------------------------EHLLAILKSRKQSRWLKEFLNSSQYVTCVETYLEDE EQLDLVVNYLKEV-Y-CEMGAKNLQQINGDAIKFISDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYAISAVDDIDYKKAEEKYIKGPS------------------------- -------------------VSKR----EREIFDEEILERKK---GKR------------- -----------------------------------------SPAWA-------------- -----------DS----------------------------------------------- --A-------------------------------------------- >ENSDNVP00000001810 ------------------------------------------------------MT-DQ- EYVLCKWKKRLWPAKILSKIGVPGKPPVTNAKEASFKVKILGLEEQTSVNCADTEPLKEE YIQNIASNL----DQGKNSSEAVEELKYRRSLKIALDILNQNDSPRQ-VP---------- ---------------------------PSEDEPSTQL----------------------- ------------------------------------------------------------ ------------SQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KHNTR-------------- ----------------SLSSTP-------------------------------------- -----------------------------------------------------------L TTCQ-------------------------------------------------------- ------------------------------------------------------------ -----------------------------------------SFLTKEELEFETP------ -----------------------------KKKREQKN----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------NPNLK TDTKKQKLKHSLTLEEGAKAHEDGTKPSECRTR--------------------------- ------------------------------------------------------------ ----------------------------------------------------D------- -----LYNASNS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------AKNCKMXES--KSL TRQKKIKPRLLPKSQTTNKSS-LKPK---------------------------------- ---------------------------EEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SKQG----------------- ------------------------------------------------------------ ------------------------------------------------------------ RKRPKGAGSPILCINDFPEDQVHPLTEESSPVSVSC------------------------ --------------------------KSDTIVSV-R------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------RANTKGR---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------RRTILDSSCXCASDDLDSSI-------------SNE--------------- --------------------------SENLAKKL-------------------------- -------DGRKKPVNLKRRK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QETNA------TLSPCRKKKCRNC------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ------------------------------------------------------------ ------------------------------ESSPGP--------------SNHGNISDSF LSKL--K--------------EEE------------------------------------ ------------------------------------------NKNTSH------------ --------------------MLRNKVKDFQ------------------------------ --------------------------------------------LPDFE----------- -------------------------------------------E-D-E-GLESSGMSSKI SSSENFSLIS-------------------------------------------------A LV-----D-EEE------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPSILSHQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PQSIEEGILVWCKLRRYPYWPAV------ ------------------------------VKTVKRKHRKANVLFIEGNTNDK-TKGFSV SLKNLKHFDCEEKQDLIDQAKEAYCQEIEWCIRLISDYRIRVGCHSFTGSFLEYFADDIS YPVRKEGIQGLVQMSFTNIAEEEL-E--ESPPETSP---SKPS--------KKLLPDRTR AARDKANKKIVEFIVKTKGAE--------------------------------------- ------------------------EHLLAILKSRKQSRWLKEFLNSSQYVTCVETYLEDE EQLDLVVNYLKQV-Y-HEIDTRSLHRINGDGIKFISDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYAISAVDDIDYKKAEEKYIKGPS------------------------- -------------------VSKR----EREIFDEEILGRKK---WKT------------- -----------------------------------------ELASE-------------- -----------DS----------------------------------------------- --K-------------------------------------------- >ENSAOWP00000020710 ------------------------------------------------------MT-DQ- EYVLCKWKKRLWPAKILSKTGVPGKPSVTNAKEISFKVEILGLEEQASVNCADTEPLKEE CIQNIASNL----DQGKNSSEAVEELKYRRSLKIALDILNQNDSPRE-VT---------- ---------------------------PSEEEPSTQL----------------------- ------------------------------------------------------------ ------------SQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KNNAR-------------- ----------------SLSSTP-------------------------------------- -----------------------------------------------------------L TTCR-------------------------------------------------------- ------------------------------------------------------------ -----------------------------------------SLLTKE--EFETP------ -----------------------------KKKGEQKN----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------NPNLK TDTKNQKLKHSFILEEGAKAREDRTKPSECRTR--------------------------- ------------------------------------------------------------ ----------------------------------------------------D------- -----LCNASNS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------ESKNCKMTES--KSL TRQKKVKPRLLVKSQTKNKSS-LKPK---------------------------------- ---------------------------EEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SKQG----------------- ------------------------------------------------------------ ------------------------------------------------------------ RKRPKGAGSPISCINDFPEDQVHPLTEESNPVSVSC------------------------ --------------------------KSDTVVSVRR------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------RANTKGQ---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------RRPMLDSSCECALDDLESSI-------------SNE--------------- --------------------------SENLAKKL-------------------------- -------DERKKPVDLKHRK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------QETNA------TLSSCRKRKCRNC------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ------------------------------------------------------------ ------------------------------ESSPGP--------------SNHGNISDSF LSKL--K--------------EEE------------------------------------ ------------------------------------------NKNTSH------------ --------------------MLRNKVKDFQ------------------------------ --------------------------------------------LPDFE----------- -------------------------------------------E-D-E-GLESSDTSSKI SSSENLSLLS-------------------------------------------------A LV-----D-EEE------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPSILSHQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PQSIEEGILVWCKLRRYPYWPAV------ ------------------------------VKKVKRKHKKANVLLIEGNTNDK-TKGFSV SLRNLKHFDCEEKQDLIDRAKEAYCREIEWCIRLISDYRIRVGCHSFTGSFLEYFADDIS YPVRKEGIQGLVQMTFTNVAEEEL-E--ESSSETSP---SKPS--------KKLLPDRTR AARDKANEKIVEFIVKTKGAE--------------------------------------- ------------------------EHLLAILKSRKQSRWLKEFLNSSQYVTCVETYLEDE EQLDLVVNYLRQV-Y-HERGTRNLHRINGDGIKFISDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYAISAVDDIDYKKAEEKYIKGPS------------------------- -------------------VSKR----EREIFDEEILERKR---WKT------------- -----------------------------------------ELASE-------------- -----------DS----------------------------------------------- --K-------------------------------------------- >ENSABRP00000001208 ------------------------------------------------------MA-DP- EYVLCKWRKRLWPAKVLCKSGDVGKSSIANAEEASLEVEILGLKEKVSVSSADTVPLSEE GIEDIASNL----GEKTNASEVVDELKYRCALRTALDFLSENASARQ-VPQLKEGV---- --------------------------SP-------RL----------------------- ------------------------------------------------------------ ------------SQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ANNRG-------------- ----------------SLSSTP-------------------------------------- -----------------------------------------------------------L HSCRSLSNLKEKLEP--------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------ETS------ -----------------------------KKKTERKN----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SPNLK TDIRKQNQK-CFVLEKRAKANENGAKPSKRSAG--------------------------- ------------------------------------------------------------ ----------------------------------------------------D------- -----LYNTSNS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------NGQNCTMPES--QSL SRQKKAKSSLSTKSQTENKLV-LKPK---------------------------------- ---------------------------EEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SKQG----------------- ------------------------------------------------------------ ------------------------------------------------------------ QRRP-GAGSPV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------RLPN------------------NLL KVQAQPLAEDTSLPVTCKSYTVANVRG--------------------------------- ------------------------------------------------------------ -------------------------------------------------RTNSRCQ---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------KRVLLDLSCKSAS-DLEKNI-------------RNE--------------- --------------------------SKNLVKQL-------------------------- -------GGGK--------KTAS-------------------SKQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------LKEQETSA------PVSSNRKRKCRNG------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ------------------------------------------------------------ ------------------------------EPSARP--------------SHRGKLSDGF LSQP--E--------------EEE------------------------------------ ------------------------------------------SKDSPR------------ --------------------VPASKVKEFQ------------------------------ --------------------------------------------LSDFK----------- -------------------------------------------E-D-E-GLESSDLPSEI SFTENLSHLS-------------------------------------------------T LV-----D-EDE------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPSILSRQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PQLIEEGILVWCKWQRYPYWPAV------ ------------------------------VRKVKRKHRKANVLFIEGNVNDK-KKGFSV SLKSLKHFDCEEKQDLIDQAKEEHRQEIEWCIQLISDYRIRVGCHSFTGSFLEYFADDIS YPVRKQCYQGLVQMTFPNVAEENL-E--ESLSETSP---QKPS--------KKLLPDRTR AARDKANKKIVEFIVKTKGAE--------------------------------------- ------------------------EHLLAILKSRKQSRWMKEFLNSSQYVTCIETYLEDE EQLDLVVNYLKEV-Y-HEMDTENLRQINGDRIKFISDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYAISAVDDIDYKKAEEKYIKGPS------------------------- -------------------VSKR----EREKFDEEILERKK---LKT------------- -----------------------------------------ELESA-------------- -----------DS----------------------------------------------- --L-------------------------------------------- >ENSCPBP00000032721 ------------------------------------------------------MT-DQ- EYILCKWKNRLWPAKVLCKIRTSGKPIVPKAKAASFKVEILGLEEQTNVNCTDTEPLEEE RIKIIASEL----DQRNKPSHPVEELKYRKALKIALDILSA--SPKQ-VR---------- ---------------------------PSDEGRTTRS----------------------- ------------------------------------------------------------ ------------AQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KENKIRTSLSPPV----TRCPI-- -----------------ASPKIK----------------LEGG----------------- ---------------------------------------------------ETL------ -----------------------------KKKKKQK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TPSPQ TDTEKNKRKCRLSSKETAKTRGNRTNSLGSKSG--------------------------- ------------------------------------------------------------ ----------------------------------------------------D------- -----FSSTWKS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------ESQHCKTAKSKLKTL TQQKKVKSKLLPKSKTGKSSSPLLKE---------------------------------- ---------------------------NEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SKKG----------------- ------------------------------------------------------------ ------------------------------------------------------------ RKRPRDASESSSPSTKSPDDTARVFVRESTPVSASC------------------------ --------------------------NSTMLISAGK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------RPNVRGL---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------KKRLLDFSITSTS-------------------------------------- ------------------------------------------------------------ -------------------------------------------PELESNS---------- ------------------------------------------------------------ ----------------------------------SEERDTPARKYKMLDGSKKP------ --------VNSKCVSWKQKTTAVSPL------RRKGGCISG------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ------------------------------------------------------------ ------------------------------EPLSGA--------------SKHKNYSDSP LSEF--K--------------KEE------------------------------------ ------------------------------------------NKGTSY------------ --------------------SPVNKTKNCQ------------------------------ --------------------------------------------LPDFD----------- -------------------------------------------E-DEE-GLESSDLSLKF SSPGDISLDT-------------------------------------------------T LV-----DEEEE------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPSILLRQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCSIEPGMLVWCKLRRYPYWPAV------ ------------------------------IKRVTRKYKKANVLLIEAGMNNKKTKGFSI GLKNLKHFDCKEKQKLIDKAKEDYSQEIEWCIELIADYRIRVGCRSFTGSFLEYCADDIS YPVRKEVNQGKLQMTFPVIAEEDL-E--ESVSETPP---IKPS--------KKVLPDRTR AARDKANSKIVDFIVKTKGAE--------------------------------------- ------------------------EHLLAILKSKKQSRWLREFLNSSQYMTC-ETYLEDE EQLDRVVNYLQEV-C-HEIDTRKLDVKNGDRIKFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYAISAVDDIDYKKAEEKYIKGPS------------------------- -------------------VSKR----EREIFDTEILEKKKLELLKT------------- -----------------------------------------DLAPE-------------- -----------DS----------------------------------------------- --V-------------------------------------------- >ENSCABP00000005079 ------------------------------------------------------MT-DQ- EYILCKWKNRLWPAKVLCKIRTSRRPVLSKAEAASFKVEILGLEEETYVNYVDTEPLEEE RIKIIASEL---ADQRNKPTHPVEELKYRKALKIALDILSA--SPKQ-VR---------- ---------------------------PSDEGQTTRS----------------------- ------------------------------------------------------------ ------------GQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KENKIKTSLSPPV----TRCPI-- -----------------SSPKIK----------------LEEG----------------- ---------------------------------------------------ETL------ -----------------------------KKKRKQK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TPSPQ TDTEKNKQKCRLSSKETAKTRGNRTNSSVSKSG--------------------------- ------------------------------------------------------------ ----------------------------------------------------D------- -----FSSTWKS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------ESQHCKTSKSKVKTL TQQKTVKSKLVPKSKIGKSSSFLLKQ---------------------------------- ---------------------------NEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SKKG----------------- ------------------------------------------------------------ ------------------------------------------------------------ RKRPRDAGEPSSPSTKFPDDTVHDFVRESTPISASC------------------------ --------------------------NSTMLISAGK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------RPNVRGL---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------KKRLLDFSITSTS-------------------------------------- ------------------------------------------------------------ -------------------------------------------PELESNI---------- ------------------------------------------------------------ ----------------------------------GEERDTPARKYKMLDGSKKP------ --------VNSKCISWKQKTTAVSPL------HKKEGCING------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ------------------------------------------------------------ ------------------------------EPLSGA--------------SKHANYSDSP LSEF--E--------------KEE------------------------------------ ------------------------------------------NKGTSH------------ --------------------SPVNKAKNCQ------------------------------ --------------------------------------------LPDFD----------- -------------------------------------------E-DEA-GLDSSDLSLKF SSPEGISPDT-------------------------------------------------T LV-----DEEEE------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPSILLRQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCSIEPGMLVWCKLPRYPYWPAV------ ------------------------------IKRVTRKYKKASVLLIEAGMNDKKAKGFSI GLKNLKHFDCKEKQNLIDKAKEDYSREIEWCIELIADYRIRVGCRSFTGSFLEYCADDIS YPVRKEVNQGKIQMTFPVIAEEDF-E--ESLSETTP---IKPS--------KKVLPDRMR AARDKANSKIVDFIVKTKGAE--------------------------------------- ------------------------AHLLAILKSKKQSRWLREFLNSSQYMTC-ETYLEDE EQLDLVVNYLQEV-C-HEIDTRKLDLKNGDRIKFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYAISAVDDIDYKKAEEKYIKGPC------------------------- -------------------VSKR----EREIFDKEILEKKKLELLKT------------- -----------------------------------------DLPPE-------------- -----------DS----------------------------------------------- --I-------------------------------------------- >ENSGAGP00000019390 ------------------------------------------------------MT-DQ- EYILCKWKNRLWPAKVLCKIRTSRRPVVSKAKAASFKVEILGLEEQTNVNCVDTQPLEEE RIKIIASEL----DQRNKPSHPVEELKYRKALRIALDILSA--SPKQ-VR---------- ---------------------------SSDEGQTTRS----------------------- ------------------------------------------------------------ ------------GQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KENKIRSSLSPPL----TRCPI-- -----------------SSPKIK----------------LEEG----------------- ---------------------------------------------------ETL------ -----------------------------REKWKQK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TPSPQ IDTEKNKQKYRLSSKEMAKTRGNRTNSSISKSG--------------------------- ------------------------------------------------------------ ----------------------------------------------------N------- -----FSSTWKS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------ESQHCKTSKSKVKTL TQQKTIKSKLLPKSRTGKSSSFLLKE---------------------------------- ---------------------------NEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SKKG----------------- ------------------------------------------------------------ ------------------------------------------------------------ RKRPRDAGEPSSPSTKFPDDTLRVFVRESTPVSASC------------------------ --------------------------NSTMLICAGK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------RPNVRGL---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------KKKLLDFSITSTS-------------------------------------- ------------------------------------------------------------ -------------------------------------------PELESNI---------- ------------------------------------------------------------ ----------------------------------NEERDTPARKYKMLDGSKKP------ --------VNSKCVSWKQKTTAVSPL------HKKGGCING------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ------------------------------------------------------------ ------------------------------EPLSGA--------------SKHTNYSDSP LSEF--K--------------KEE------------------------------------ ------------------------------------------NKGTSH------------ --------------------SPVNKAKNCQ------------------------------ --------------------------------------------LPDFD----------- -------------------------------------------E-DEA-GLDSSDLSLKF SSPEGISPNT-------------------------------------------------T LV-----DEEEE------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPSILLRQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCSIEPGMLVWCKLPRYPYWPAV------ ------------------------------IKRVTRKYKKASVLLIEAGMNGKKAKGFSI GLKNLKHFDCKEKQNLIDKAKEDYSREIEWCIELIADYRIRVGCRSFTGSFLEYCADDIS YPVRKEVNQGKIQMTFPVIAEEDF-E--ESLSETTP---IKPS--------KKVLPDRMR AARDKANSKIVDFIVKTKGAE--------------------------------------- ------------------------AHLLAILKSKKQSRWLREFLNSSQYMTC-ETYLEDE EQLDLVVNYLQEV-C-HEIDTRKLDVKNGDRIKFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYAISAVDDIDYKKAEEKYIKGPC------------------------- -------------------VSKR----EREIFDKEILEKKELELLKT------------- -----------------------------------------DLHPE-------------- -----------DS----------------------------------------------- --V-------------------------------------------- >ENSPSIP00000002867 ------------------------------------------------------MT-DQ- EYILCKWKNRLWPAKVLSKIRTSRKPVVSKAKAASFKVEILGLEEQTNVNSTDTEPLEKE HIQRIASEL----DQKNKPRHPVEELKYRKALKIALDILSN--FPKQ-VR---------- ---------------------------SSDDRQTTRS----------------------- ------------------------------------------------------------ ------------TQ---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KENKI-TSLPSSV----TRCPV-- -----------------FSPKIE----------------LEGG----------------- ---------------------------------------------------ESL------ -----------------------------KEKREQK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TPSPQ TDTEKNKQKCQLSSEEAAKTCGNGTKSSVSESG--------------------------- ------------------------------------------------------------ ----------------------------------------------------D------- -----FSRTWQS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------ESQHCKTFKSKVKML KKQKKVNSELLQKSKTGKNVSPLLKK---------------------------------- ---------------------------NEK------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------STKG----------------- ------------------------------------------------------------ ------------------------------------------------------------ RKRPRDAGEPSSPRTEFPDDTARAFVSESTPISSSC------------------------ --------------------------NSATLISVGK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------RPNVRRL---- ------------------------------------------------------------ ------------------------------------------------------P----- ---------RKRLLDFSITCAS-------------------------------------- ------------------------------------------------------------ -------------------------------------------PELGNNI---------- ------------------------------------------------------------ ----------------------------------SGKSDSPAKKIKILDGSRET------ --------VNSKCASWKQKTTAVSPT------CRKRGCISG------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ------------------------------------------------------------ ------------------------------EPLSGA--------------SEHKDSLDSP LSEL--E--------------K-E------------------------------------ ------------------------------------------NQAISH------------ --------------------NPVNKAKNCQ------------------------------ --------------------------------------------LPDFD----------- -------------------------------------------E-DEE-GLESSDLSLKF CSPGSVSLDS-------------------------------------------------T LV-----D-EDE------------------------------------------------ EEDEE------------------------------------------------------- ---------------------------------------------LPSILLRQE------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PCSIEPGMLVWCKLPRYPYWPAV------ ------------------------------IKSVKRKYKKANVLLIEGGMNAKKAKGFST GLKNLKHFDCEEKQKLTDKAKEDYSQEIKWCIKLIADYRIRVGCRSFTGSFLEYCADDIS YPVRKEVNQGRVPMSFPNIAEEDL-E--ESVSETTP---ILPS--------KKVLPDRTR AARDKANSKIVDFIVKTKGAE--------------------------------------- ------------------------EHLVAILKSKKQSRWLREFLNSSQYMTC-ETYLEDE EQLDLVVNYLQEV-C-HEIDTRKLDVKNGDRIKFILDVLLP-------E----------- ------------------------------------------------------------ -----A------------------------------------------------------ ----------IIYAISAVDDIDYKKAEEKYIKGPS------------------------- -------------------VSKRYGGL--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --V--------------------------------------------