>ENSBIXP00000021988 -------------------------------------------------- ----Mx-DA-KYVLCRWKKRLWPAKVLAGTEKSAKN--KRKKGYFLNVQI LSLDKKIKVKSAEAKVLRKVHIEDIASSL---ASQDGTPAAPLEELTYRR SLRVALDVLNE-------------------xxx----------------- ------xxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- -------------------xxxxxx--------------------xxxx- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------EGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxxxxxxxxx-xxxxxx xxxxxxxxxxxxxxxxxxxxxx----xxxxxx------------------ ---xxxxxxxxxxxxx-----xxxxxxxxxxxx------xxx-xHLGLDS GQRP---------------------------------------------- --xxxxxxxx---------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------------------------- ---------------------------------xxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxx-xxE--E-ARP-- --L----------------------------------------------- -------SEEFMEPSxxx-xxx-------xxx------------------ ------------------------------EDDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWHKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPR-GRGISVLLRRLKHFDC KEKQALLDEAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDVQGTRFPQLSGGDP-E--EPVAGSPQGR-RPAY------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------SHLRAI LRNRKPSRWLKTFLSSGQYMTCVETYLEDEEQLDLVVKYLQGV-Y-KQAG CQLLARGHGDGIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYIRGPA----- ---------------------------------------LSSR----EKE IFDNQLLEERN---RRC--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSBTAP00000009840 -------------------------------------------------- ----Mx-DA-KYVLCRWKKRLWPAKVLAGTEKSAKN--KRKKGYFLNVQI LSLDKKIKVKSAEAKVLRKVHIEDIASSL---ASQDGTPAAPLEELTYRR SLRVALDVLNE-------------------xxx----------------- ------xxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- -------------------xxxxxx--------------------xxxx- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------EGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxxxxxxxxx-xxxxxx xxxxxxxxxxxxxxxxxxxxxx----xxxxxx------------------ ---xxxxxxxxxxxxx-----xxxxxxxxxxxx------xxx-xHLGLDS GQRP---------------------------------------------- --xxxxxxxx---------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------------------------- ---------------------------------xxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxx-xxE--E-ARP-- --L----------------------------------------------- -------SEEFMEPSxxx-xxx-------xxx------------------ ------------------------------EDDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWHKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPR-GRGISVLLRRLKHFDC KEKQALLDEAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDVQGTRFPQLSGGDP-E--EPVAGSPQGR-RPAY------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------SHLRAI LRNRKPSRWLKTFLSSGQYMTCVETYLEDEEQLDLVVKYLQGV-Y-KQAG CQLLARGHGDGIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYIRGPA----- ---------------------------------------LSSR----EKE IFDNQLLEERN---RRC--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSBIXP00005002592 -------------------------------------------------- ----Mx-DA-KYVLCRWKKRLWPAKVLAGTEKSAKN--KRKKGYFLNVQI LSLDKKIKVKSAEAKVLRKVHIEDIASSL---ASQDGTPAAPLEELTYRR SLRVALDVLNE-------------------xxx----------------- ------xxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- -------------------xxxxxx--------------------xxxx- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------EGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxxxxxxxxx-xxxxxx xxxxxxxxxxxxxxxxxxxxxx----xxxxxx------------------ ---xxxxxxxxxxxxx-----xxxxxxxxxxxx------xxx-xHLGLDS GQRP---------------------------------------------- --xxxxxxxx---------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------------------------- ---------------------------------xxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxx-xxE--E-ARP-- --L----------------------------------------------- -------SEEFMEPSxxx-xxx-------xxx------------------ ------------------------------EDDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWHKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPR-GRGISVLLRRLKHFDC KEKQALLDEAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDVQGTRFPQLSGGDP-E--EPVAGSPQGR-RPAY------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------SHLRAI LRNRKPSRWLKTFLSSGQYMTCVETYLEDEEQLDLVVKYLQGV-Y-KQAG CQLLARGHGDGIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYIRGPA----- ---------------------------------------LSSR----EKE IFDNQLLEERN---RRC--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSBMUP00000004989 -------------------------------------------------- ----Mx-DA-KYVLCRWKKRLWPAKVLAGTEKSAKN--KRKKGYFLNVQI LSLDKKIKVKSAEAKVLRKAHIEDIASSL---ASQDGTPAAPLEELTYRR SLRVALDVLNE-------------------xxx----------------- ------xxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- -------------------xxxxxx--------------------xxxx- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------EGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxxxxxxxxx-xxxxxx xxxxxxxxxxxxxxxxxxxxxx----xxxxxx------------------ ---xxxxxxxxxxxxx-----xxxxxxxxxxxx------xxx-xHLGLDS GQRP---------------------------------------------- --xxxxxxxx---------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------------------------- ---------------------------------xxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxx-xxE--E-ARP-- --L----------------------------------------------- -------SEEFMEPSxxx-xxx-------xxx------------------ ------------------------------EDDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWHKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPR-GRGISVLLRRLKHFDC KEKQALLDEAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDVQGTRFPQLSGGDP-E--EPVAGSPQGR-RPAY------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------SHLRAI LRNRKPSRWLKTFLSSGQYMTCVETYLEDEEQLDLVVKYLQGV-Y-KQAG CQLLARGHGDGIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYIRGPA----- ---------------------------------------LSSR----EKE IFDNQLLEERN---RRC--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSCHIP00000024640 -------------------------------------------------- ----Mx-DA-KYVLCRWKKRLWPAKVLAGTEKSAKN--KRKKGFFLNVQI LSLDKKIKVKSAEAKVLRKVHIEDIASSL---ALQDGTPTAPLEELTYRR SLRVALDVLNE-------------------xxx----------------- ------xxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- -------------------xxxxxx--------------------xxxx- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------EGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxxxxxxxxx-xxxxxx xxxxxxxxxxxxxxxxxxxxxx----xxxxxx------------------ ---xxxxxxxxxxxxx-----xxxxxxxxxxxx------xxx-xRLGLDG GQRP---------------------------------------------- --xxxxxxxx---------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------------------------- ---------------------------------xxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxx-xxK--E-ARP-- --S----------------------------------------------- -------SEEFMEPSxxx-xxx-------xxx------------------ ------------------------------EDDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYRE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PPSFEVGMLVWHKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPR-GRGISVLLRRLKHFDC KEKQALLDEAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDVQGTRFPQLSGGDP-E--EPVAGNPQGR-RPAY------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------SHLWAI LRNKKPSRWLKTFLSSGQYMTCVETYLEDEEQLDLVVKYLQGV-Y-EQAG CQLLARGHGDGIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYETAEKKYIRGPV----- ---------------------------------------LSSR------- -------------------------------------------------- ---------------xxxxxxxxxxx-----------------------x xxxxxx-------------------------------------------- ----------------------------------------------- >ENSOARP00000012384 -------------------------------------------------- ----Mx-DA-KYVLCRWKKRLWPAKVLAGTEKSAKN--KRKKGFFLNVQI LSLDKKIKVKSAEAKVLRKVHIEDIASSL---ASQDGTPTAPLEELTYRR SLRVALDVLNE-------------------xxx----------------- ------xxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- -------------------xxxxxx--------------------xxxx- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------EGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxxxxxxxxx-xxxxxx xxxxxxxxxxxxxxxxxxxxxx----xxxxxx------------------ ---xxxxxxxxxxxxx-----xxxxxxxxxxxx------xxx-xRLDLDG GQRL---------------------------------------------- --xxxxxxxx---------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------------------------- ---------------------------------xxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxx-xxK--E-ARP-- --S----------------------------------------------- -------SEEFMEPSxxx-xxx-------xxx------------------ ------------------------------EDDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYRE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PPSFEVGMLVWHKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPR-GRGISVLLRRLKHFDC KEKQALLDEAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDVQGTRFPQLSGGDP-E--EPVAGNPQGR-RPAYxxVLHxx xRKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------SHLWAI LRNKKPSRWLKTFLSSGQYMTCVETYLEDEEQLDRVVKYLQGV-Y-EQAG CQLLARGHGDGIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYETAEKKYIRGPV----- ---------------------------------------LSSR----EKE IFDNQLLEERN---RRC--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSTTRP00000010436 -------------------------------------------------- ----IxxDA-KYVLCRWKKRLWPAKVLAGTEKSAKN--KRKKEFFLHVQI LSLDKKIKVKSTGAQILKKSHIEGIASSL---ALQNEVAATPLEELAYRR SLRVALDVLNERT---------------xxxxx----------------- ------RSSREExxxxxxxxx----------------------------- -------------------------------------------------- -------------------xxxxxxxxxxxx--------xxxxxx----- -------------------------------------------------- ---------------xxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxxxx------------------------ ------xx-----------------------------------------x xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNLAxxxx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxx--------------------------------------- ------------------------x------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------x-xx--x xxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------------- -------xxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- ----x--------------------------------------------- ---------------------------------------xxxxxxxxxxx xxxxxxxxxxx------------xxxxx--xxxxxxxxx----------- ---------xxxxxxxxxxxxxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------RP-- --P----------------------------------------------- -------SEESVELDxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYRE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VRSVRRRDKKASVLFIEGNMNPK-GRGITVSLRRLKHFDC KEKQALLDEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQRDVQGTRFPPLSGVGP-E--QALAGNPRGR-RPAC------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------SHLRAI LKNRKPSRWLKTFLSSGQYVTCVETYLEDEEQLDLVVKYLQGV-Y-QEAG SRLLARRHADGIRFVLDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYIRGPS----- ---------------------------------------LSYR----EKE IFDTQLLEERS---R----------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSMLEP00000020020 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEYFLDVQI LSLEEKIKVKSTEVEILEKSQIEAIASSL---ASQSEVPAAPLEELAYRR SLRVALDVLSEGPIWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSVxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRLRLDG SQRPPAAQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxx----------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --VDETRRPP---------------------------------------- ----------------------------------xPxSx----------- --------------------------------------KLE--E-DCQ-- --S----------------------------------------------- -------SEASMGPNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYKKYPFWPAV-------------------------- ----------VKSVRQREKKASVLYIEGHMNPK-KKGFTVSLKSLKHFDC KEKQTLLNQARVDYDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVPGTRFPQLSKGSP-E--EPVVGRPLGQ-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDLVVKYLQGV-Y-QEVG AKVLRRTNGDRIRFILDVLLP-------E-----------------xxxx xxxxxxxxxxxxx----------xxxxxxxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------x------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx x-x-------------------------------------------- >ENSCATP00000015381 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEYFLDVQI LSLEEKIKVKSTEVEILEKSQIEAIAASL---ASQSEVPAAPLEELAYRR SLRVALDVLSEGPIWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSVxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRLRLDG SQRPPAAQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxx----------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --VDETRRPP---------------------------------------- ----------------------------------xPxSx----------- --------------------------------------KLE--E-DCQ-- --S----------------------------------------------- -------SEASMGPNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYKKYPFWPAV-------------------------- ----------VKSVRQRDKKASVLYIEGRMNPK-RKGFTVSLKSLKHFDC KEKQTLLNQARVDYDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVPGTRFPQLSKGSP-E--EPVVGRPLGQ-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDLVVKYLQGV-Y-QEVG AKVLRRTNGDRIRFILDVLLP-------E-----------------xxxx xxxxxxxxxxxxx----------xxxxxxxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------x------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx x-x-------------------------------------------- >ENSPANP00000045539 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLSRTETSTKN--KRKKEYFLDVQI LSLEEKIKVKSTEVEILEKSQIEAIASSL---ASQSEVPAAPLEELAYRR SLRVALDVLSEGPIWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSVxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRLRLDG SQRPPAAQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxx----------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --VDETRRPP---------------------------------------- ----------------------------------xPxSx----------- --------------------------------------KLE--E-DCQ-- --S----------------------------------------------- -------SEASMGPNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYKKYPFWPAV-------------------------- ----------VKSVRQRDKKASVVYIEGHMNPK-RRGFTVSLKSLKHFDC KEKQTLLNQARVDYDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS CPVRKSIQQDLLGTRFPQLSKGSP-E--EPVVGRPLGQ-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDLVVKYLQGV-Y-QEVG AKVLRRTNGDRIRFILDVLLP-------E-----------------xxxx xxxxxxxxxxxxx----------xxxxxxxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------x------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx x---------------------------------------------- >ENSMFAP00000041768 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEYFLDVQI LSLEEKIKVKSTEVEILEKSQIEAIASSL---ASQSEVPAAPLEELAYRR SLRVALDVLSEGPIWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSVxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVL-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRLRLDG SQRPPAAQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxx----------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --VDETRRPP---------------------------------------- ----------------------------------xPxSx----------- --------------------------------------KLE--E-DYQ-- --S----------------------------------------------- -------SEASMGPNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYKKYPFWPAV-------------------------- ----------VKSVRQRDKKASVVYIEGQMNPK-RKGFTVSLKSLKHFDC KEKQTLLNQARVDFDQAIGWCISLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDAPGTRFPQLSKGSP-E--EPVVGRPLGQ-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDLVVKYLQGV-Y-QEVG AKVLRRTNGDRIRFILDVLLP-------E-----------------xxxx xxxxxxxxxxxxx----------xxxxxxxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------x------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx x-x-------------------------------------------- >ENSMNEP00000003974 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEYFLDVQI LSLEEKIKVKSTEVEILEKSQIEAIAASL---ASQSEVPAAPLEELAYRR SLRVALDVLSEGPIWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSVxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRLRLDG SQRPPAAQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxx----------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --VDETRRPP---------------------------------------- ----------------------------------xPxSx----------- --------------------------------------KLE--E-DCQ-- --S----------------------------------------------- -------SEASTGPNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYKKYPFWPAV-------------------------- ----------VKSVRQRDKKASVVYIEGHMNPK-RKGFTVSLKSLKHFDC KEKQTLLNQARVDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDAPGTRFPQLSKGSP-E--EPVVGRPLGQ-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDLVVKYLQGV-Y-QEVG AKVLRRTNGDRIRFILDVLLPxxxxxxx---------------------- --xxxxxxxxxxx----------xxxxxxxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------x------------------------------- -------------------------------------------------- --------------------------xxxxxxxxx--------------- ----------------------------------------------- >ENSCANP00000020965 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEYFLDVQI LSLEEKIKVKSTEVEILEKSQIEAIASSL---ASQNEVPVAPLEELAYRR SLRVALDVLSEGPIWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSVxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRLCLDG SQRPPAAQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxx----------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --VDESRRPP---------------------------------------- ----------------------------------xLxSx----------- --------------------------------------KLE--E-DCQ-- --S----------------------------------------------- -------SKASMGSNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PHSFEVGMLVWLKYKKYPFWPAV-------------------------- ----------VKSVRQRDKKASVLYIEGHMNPK-RKGFTVSLKSLKHFDC KEKQTLLNQAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPPLSKGSP-E--EPVVGRPLGQ-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDLVVKYLQGI-Y-QEVG AKVLRRTNGDRIRFILDVLLP-------E-----------------xxxx xxxxxxxxxxxxxxxxxxxxxxxx----xxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------x------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx x-x-------------------------------------------- >ENSRBIP00000025387 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSTKI--KRKKEYFLDVQI LSLEEKIKVKSTEVEILEKSQIEAIASSL---ASQNEVPAAPLEELAYRR SLRVALDVLSEGPIWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSVxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRLRLDG SQRPRAAQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxx----------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --VDESRRPP---------------------------------------- ----------------------------------xPxSx----------- --------------------------------------KPE--E-DCQ-- --S----------------------------------------------- -------SEASMGSNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYKKYPSWPAV-------------------------- ----------VKSVRQRDKKASVLYIEGHMNPK-RKGFTVSLKSLKHFDC KEKQTLLNQAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGSP-E--EPVVGHPLGQ-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDLVVKYLQGV-Y-QEVG AKVLRRTNGDRIRFILDVLLPxxxxxxx---------------------- --xxxxxxxxxxxxxxxxxxxxxx----xxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------x------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx x---------------------------------------------- >ENSRROP00000018387 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSTKI--KRKKEYFLDVQI LSLEEKIKVKSTEVEILEKSQIEAIASSL---ASQNEVPAAPLEELAYRR SLRVALDVLSEGPIWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSVxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRLRLDG SQRPRAAQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxx----------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --VDESRRPP---------------------------------------- ----------------------------------xPxSx----------- --------------------------------------KPE--E-DCQ-- --S----------------------------------------------- -------SEASMGSNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYKKYPSWPAV-------------------------- ----------VKSVRQRDKKASVLYIEGHMNPK-RKGFTVSLKSLKHFDC KEKQTLLNQAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGSP-E--EPVVGHPLGQ-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDLVVKYLQGV-Y-QEVG AKVLRRTNGDRIRFILDVLLPxxxxxxx---------------------- --xxxxxxxxxxxxxxxxxxxxxx----xxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------x------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx x---------------------------------------------- >ENSTGEP00000013346 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLSRTETSTKN--KRKKEYFLDVQI LSLEEKIKVKSTEVEILEKSQIEAIASSL---ASQSEVPAAPLEELAYRR SLRVALDVLSEGPIWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSVxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRLRLDG SQRPPAAQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxx----------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --VDETRRPP---------------------------------------- ----------------------------------CPxSx----------- --------------------------------------KLE--E-DCQ-- --S----------------------------------------------- -------SEASMGPNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYKKYPFWPAV-------------------------- ----------VKSVRQRDKKASVVYIEGHMNPK-RKGFTVSLKSLKHFDC KEKQTLLNQARVDYDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS CPVRKSIQQDLLGTRFPQLSRGSP-E--EPVVGSPLGQ-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDLVVKYLQGV-Y-QEVG AKVLRRTNGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDEVDYKTAEEKYIKGPS----- ---------------------------------------LSYR----EKE IFDNQLLEERK---RRR-x------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSCSAP00000008342 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEYFLDVQI LSLEEKIKVKSTEVEILEKSQIEAIASSL---ASQSEVPAAPLEELAYRR SLRVALDVLSEGPIWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSVxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRLRLDG SQRPPAAQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxx----------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --VDETRRPP---------------------------------------- ----------------------------------CPxSx----------- --------------------------------------KLE--E-DCQ-- --S----------------------------------------------- -------SEASMGSNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYKKYPVWPAV-------------------------- ----------VKSVRQRDKKASVLYIEGHMNPK-RKGFTVSLKSLKHFDC KEKQTLLNQAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDRLGTRFPQLSKGSP-E--EPVVGRPLGQ-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDLVVKYLQGV-Y-QEVG AKVLRRTNGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDEVDYKTAEEKYIKGPS----- ---------------------------------------LSYR----EKE IFDNQLLEERK---RRR-x------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSPTEP00000034771 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEYFLDVQI VSLEEKIKVKSTEVEILEKSQIEAIASSL---ASQNEVPAAPLEELAYRR SLRVALDVLSEGPIWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSVxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRLRLDG SQRPPAAQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxx----------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --VDESRRPP---------------------------------------- ----------------------------------CPxSx----------- --------------------------------------KLE--E-ACQ-- --S----------------------------------------------- -------SAASMGSDxxx-xxx-------xxx------------------ ------------------------------DEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWHKYKKYPFWPAV-------------------------- ----------VKSVRQRDKKASVLYIEGNMNPK-KKGFTVSLKSLKHFDC KEKQTLLNQAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS SPVRKSIQQDVLGTRFPQLSKGSP-E--EPVVGRPLGQ-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDLVVKYLQGV-Y-QEVG AKVLRRTNGDRIRFILDVLLP-------Exxxxxxxxxxxxxxxxxx--- ----------------------------------xxxxxxxxxxxxxxxx xxxxxA-------------------------------------------- --------------------IICAISAVDEVDYKTAEEKYIKGPS----- ---------------------------------------LSYR----EKE IFDNQLLEERK---RCR-x------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSPTRP00000061864 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTATSTKN--KRRKEYFLAVQI LSLEEKIKVKSTEVEILEKSQIEAIASSL---ASQNEVPAAPLEELAYRR SLRVALDVLSEGSIWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSAxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTAP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRPRLDG SQRPPAVQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxx--------xxxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --ADATRCLP---------------------------------------- ----------------------------------xPxSx----------- --------------------------------------KLE--K-ECQ-- --S----------------------------------------------- -------SEESTGSNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWHKYKKYPFWPAV-------------------------- ----------VKSVRQRDKKASVLYIEGHMNPK-MKGFTVSLKSLKHFDC KEKQTLLNQAREDFNQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTKFPQLSKGSP-E--EPVVGCPLGQ-RQPC------- -RKMLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDVVVKYLQGV-Y-QEVG AKVLQRTNGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xx------------------------------------------------ -----xxx-----------x--xxxxxxxxxxxxxxxxxxxxxxxxxxxx xx--------------------------------------------- >ENSPPAP00000006424 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTATSTKN--KRRKEYFLAVQI LSLEEKIKVKSTEVEILEKSQIEAIASSL---ASQNEVPAAPLEELAYRR SLRVALDVLSEGSIWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSAxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTAP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRPRLDG SQRPPAVQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxx--------xxxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --ADATRCLP---------------------------------------- ----------------------------------xPxSx----------- --------------------------------------KLE--K-ECQ-- --S----------------------------------------------- -------SEESTGSNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWHKYKKYPFWPAV-------------------------- ----------VKSVRQRDKKASVLYIEGHMNPK-MKGFTVSLKSLKHFDC KEKQTLLNQAREDFNQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTKFPQLSKGSP-E--EPVVGCPLGQ-RQPC------- -RKMLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDVVVKYLQGV-Y-QEVG AKVLQRTNGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xx------------------------------------------------ -----xxx-----------x--xxxxxxxxxxxxxxxxxxxxxxxxxxxx xx--------------------------------------------- >ENSGGOP00000021977 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTATSTKN--KRRKEYFLAVQI LSLEEKIKVKSTEVEILEKSQIEAIASSL---ASQNEVPAAPLEELAYRR SLRVALDVLSEGSIWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSAxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTAP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRPRLDG SQRPPAVQLxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxx--------xxxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --ADATRCLP---------------------------------------- ----------------------------------xPxSx----------- --------------------------------------KLE--K-ECQ-- --S----------------------------------------------- -------SEESMGSNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWHKHKKYPFWPAV-------------------------- ----------VKSVRQRDKKASVLYIEGHMNPK-MKGFTVSLKSLKHFDC KEKQTLLNQAREDFNQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTKFPQLSKGSP-E--EPVVGCPLGQ-RQPC------- -RKMLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDLVVKYLQGV-Y-QEVG AKVLQRTNGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxx-xxxxxxxxxxxxxxxxxxxxxxxxxxxx xx------------------------------------------------ -----xxx-----------x--xxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx-------------------------------------------- >ENSP00000498656 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTATSTKN--KRRKEYFLAVQI LSLEEKIKVKSTEVEILEKSQIEAIASSL---ASQNEVPAAPLEELAYRR SLRVALDVLSEGSIWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------GNSAxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTAP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRPRLDG SQRPPAVQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxx--------xxxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --ADATRCLP---------------------------------------- ----------------------------------CPxSx----------- --------------------------------------KLE--K-ECQ-- --S----------------------------------------------- -------SEESMGSNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWHKHKKYPFWPAV-------------------------- ----------VKSVRQRDKKASVLYIEGHMNPK-MKGFTVSLKSLKHFDC KEKQTLLNQAREDFNQDIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTKLPQLSKGSP-E--EPVVGCPLGQ-RQPC------- -RKMLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDLVVKYLQGV-Y-QEVG AKVLQRTNGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDEVDYKTAEEKYIKGPS----- ---------------------------------------LSYR----EKE IFDNQLLEERN---RRR--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSNLEP00000032204 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEHFLDVQI LSLEEKIKVKSTEAEILEKSQIEAIASSL---ASQNEVPAAPLEELAYRR SLRVALDVLSDGPVWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------GNSAxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVL-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRLRLDG SQRPPAGQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxx--------xxxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --VGETRCPP---------------------------------------- ----------------------------------CPxSx----------- --------------------------------------KLE--K-DCQ-- --S----------------------------------------------- -------SEESMGSNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRVLLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYKKYPSWPAV-------------------------- ----------VKSVRQRDKKASVLYIEGHMNPK-MKGFTVSLKSLKHFDC KEKQTLLSQAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTKFPQLSKGSP-E--EPVVGWPLGQ-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQSFLNSSQYVTCVETYLEDEGQLDLVVKYLQGV-Y-QEVG AKVLRRTNGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDEVDYKTAEEKYIKGPS----- ---------------------------------------LSYR----EKE IFDNQLLEERN---RRR--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSANAP00000018047 x------------------------------------------------- ----Mx-DA-KFVLCRWEKRLWPAKVLARTKTSTKN--KRKKEYFLDVQI LSLEEKIQVRSTEVEILEKSHIEAIASSL---ASQNEVPAAPLEELAYRR SLRVALDVLSEGLVWSQ-Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxx- xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNLAxxxxxxx xxxxxx-xx----x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxRPRLDG SQRLPAVQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxx----------xxxx----------------- -------------------------------------------------- ---------------------------------xxx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --VDETRRxx---------------------------------------- ----------------------------------x-xSx----------- --------------------------------------ELE--E-DCQ-- --S----------------------------------------------- -------SEASMRSNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGDMNPK-GKGITVSLRRLKHFDC KDKQTLLNQAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTKFPQLSKGSP-E--EPVLGSPLGQ-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLQTFLSSSQYVTCVETYLEDEGQLDLVVKYLQGV-Y-QEVG AKALRRTNGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDEVDYRTAEEKYMKGPS----- ---------------------------------------LSYR------- -------------------------------------------------- -xxxxxxxxxxxxxxx---------------------------------- --xxxx-------------------------------------------- ----------------------------------------------- >ENSPCOP00000007780 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEFFLDVQI LSLEEKIKVKSTDAEVLRKSQIEAIASSL---ASQNEAPAAPLEELTYRR SLRVALDVLSERASSSQ-E------------------------------- ------GSSRTG-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxxxxxxxxxxxxx--------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSAxxxxxxx xxxxxx-x------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxx--------------------------------------- ------------------------xxxxxx----xxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVP-AA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxx-xRPCLDG CQRPPATRLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxx----------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --AEDTRSLR---------------------------------------- ----------------------------------xPxSx----------- --------------------------------------KLE--E-DLQ-- --S----------------------------------------------- -------SEESMEFSxxx-xxx-------xxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVKRRDKKASVLFIEGDMNPK-GRGITVSLRRLKHFDC KEKQTLLNKAREDFDQAIGWCVSLITDYRVRLGCGSFTGSFLEYYAAHIS YPVRKSIQQDALGTRFPKLSLGDP-K--EPEVDSALGW-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------SHLRAV LKSKRPSRWLETFLSSSQPVTCVETYLEDEEQLDLVVKYLQGV-C-QEMG STVLTRTHGDRIRFVLDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYIKGPS----- ---------------------------------------LSYR----EKE IFDNQLLEERS---RRC--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSMICP00000003552 -------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEFFLDVQI LSLEEKIKVKSTDVEVLRKSQIEAIAASLxCAASQNEVPAAPLEELTYRR SLRVALDVLSERASLSQ-E------------------------------- ------GSSRTG-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxxxxxxxxxxxxx--------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNTVxxxxxxx xxxxxx-x------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxx--------------------------------------- ------------------------xxxxxx----xxxxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxx-xRPCLDG SQRPPATPLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxx----------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- --AEDARSLR---------------------------------------- ----------------------------------xSxSx----------- --------------------------------------KLE--E-DLQ-- --S----------------------------------------------- -------SEESMEFSxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGDMDPK-GRGITVSLRRLKHFDC KEKQALLNKAREDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAAHIS YPVRKSIQQDALGTRFPQLSRGDP-K--EPEVDSALGW-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------SHLRAV LKSRRPSRWLETFLSSSQPVTCVETYLEDEEQLDLVVKYLQGV-C-QEMG STVLTRTHGDRIRFVLDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYIKGPS----- ---------------------------------------LSYR----EKE IFDNQLLEERS---RRC--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------x >ENSOGAP00000003037 -------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSTKN--KRKKEFFLDVQI LSLEEKIKVRSTEVEVLKKSQIEAIAASLxLSASQNEVPAAPLEELTYRR SLRVALDVLNERTSVSQ-E------------------------------- ------GSSRTE-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxxxxxxxxxxxxx--------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KExxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSAxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxxxxxxx------- -------------------------------------------------- -----------------------xx------------------------- -----xxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTIP-AA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx x--------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxx-xRPC--- -----xKQxxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxx----------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxS----------------------------------------------- -------SEESMEFNxxx-xxx-------xxx------------------ ------------------------------EDDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGDMNPK-GRGITVSLRRLKHFDC KEKQTLLNKAREDFDQAIGWCVSLITDYRVRLGCGSFSGSFLEYYAADIS YPVRKSIQQDALGTRFPQLSKGSS-E--EPEAVSALGR-RLPC------- -RKVLPDRSRAARDRANQKLVEYIVKARGTE------------------- --------------------------------------------SHLRAI LKSRRPSRWLETFLSSSQAMTCVETYLEDEEQLDLVVKYLQGF-C-QELG GPVLTRAHSDRIRFVLDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYIKGPS----- ---------------------------------------LSYR----EKE MFDNQLLEERN---RRH--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSSDAP00000006833 x------------------------------------------------- ----Mx-DA-KYVLCRWERRLWPAKVLARTETSTKN--KRKKEFFLDVQI LSLEEKLSVKSTEVEALQKSQIENIASFL---ASQEEVPAAPLEELTYRR SLRVALDVLNERDRICQ-E------------------------------- ------GPSRRxxxx-----xxxxxx------------------------ -x-----xxxxxxxxxxxxxxx----------------------xx---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KExxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSAxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxx----------------------------------------- ----------------------xx-------------------------- -------------------------------------------------- ------------------------------------xxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVP-PA--x xxx------------------------xxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- ----xxxxx------------xxxxxx--------------xxxxxxxxx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --S----------------------------------------------- -------SEESMECGxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PSSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSIRRRDKKASVLFIEGDMNPK-GRGITVPLRRLKHFDC EEKQALLDKAKEDFDRDIGSCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDILGTRFPQLNKGDL-E--EPVEGSTAGR-RQPC------- -RKVLPDRSRAARDRANQRLVEYIVKTRGAE------------------- --------------------------------------------SHLQAI LRSRRPSRWLKTFLSSSQYVTCVETYLEDEEQLDLVVKYLQGL-Y-QQMD GEVLAGVNGDSIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYIKGPS----- ---------------------------------------LSYR----EKE IFDNQLLEERN---RR---------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSUPAP00010016854 -------------------------------------------------- ----Mx-DA-KYVLCRWERRLWPAKVLARTETSTKN--KRKKEFFLDVQI LSLEEKIQVKSTEVEALQKSQIENIASFL---ASQEEVPAAPLEELTYRR SLRVALDVLNERDRICQ-E------------------------------- ------GPSRRxxxx-----xxxxxx------------------------ -x-----xxxxxxxxxxxxxxx----------------------xx---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KExxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSAxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxx----------------------------------------- ----------------------xx-------------------------- -------------------------------------------------- ------------------------------------xxx----------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVP-PA--x xxx------------------------xxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx----------------xxxxxxx---------- -------------------------------------------------x xxxxx--------------------------------------------- --xxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --S----------------------------------------------- -------SEESMECGxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PSSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSIRRRDKKASVLFIEGDMNPK-GRGITVPLRRLKHFDC EEKQALLDKAKEDFDRDIGSCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLNKGDL-E--EPVEGSTXGR-RQPC------- -RKVLPDRSRAARDRANQRLVEYIVKTRGAE------------------- --------------------------------------------SHLQAI LRSRRPSRWLKTFLSSSQYVTCVETYLEDEEQLDLVVKYLQGL-Y-QQMD GEVLAGVNGDSIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYIKGPS----- ---------------------------------------LSYR----EKE IFDNQLLEERN---RR---------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSUAMP00000018502 -------------------------------------------------- ----Mx-DA-QYVLCRWEKRLWPAKVLARTEMSTKN--KRKKEFFLSVQI LSLDEKIEVRSTDVETLKTAHIERIASSL---ASENEVPAEPLEELAYRR SLRVALDVLNQRSSLPQ-E------------------------------- ------TSSGEE-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxx-xxxxxxxxxxxxxxxxxxxxxx--------- -------------------------------------------------- --------------------xxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KAxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RHLAxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- --------------------------------xxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxx--xxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVL-PT--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxx-xRLCPDG SQRPPATQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx---------------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxxxxxxxxxxxE-DRQ-- --S----------------------------------------------- -------SGESVEFSxxx-xxx-------xxx------------------ ------------------------------EDDEE--------------- -------------------------------------------------- -----------------------------------PPRILFYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKHQKYPFWPAV-------------------------- ----------VKSVRRREKKASVLFIEGHMDPK-GRGITVSLKRLKHFDC KEKQALLNEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGDP-E--EPVVGSPQRK-RRPY------- -RKVLPDRSRAARDRANQKLVEYIVKARGTE------------------- --------------------------------------------GHLRAI LKNRKPSRWLKTFLNSGQYMTCVETYLEDEEQLDLVVKYLQGV-Y-QETG SRTLARINGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAIAAVDAVDYKTAEEKYLKGPS----- ---------------------------------------LSYR----EKE IFDNQLLEERS---QRC--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSAMEP00000003492 -------------------------------------------------- ----Mx-DA-QYVLCRWEKRLWPAKVLARTETSTKN--KRKKEFFLSVQI LSLDEKIEVRSTDVETLKTAHIERIASSL---ASENEVRAEPLEELAYRR SLRVALDVLNQRSSLPQ-E------------------------------- ------TSSGEE-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxx-xxxxxxxxxxxxxxxxxxxxxx--------- -------------------------------------------------- --------------------xxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RRLAxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- --------------------------------xxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxx--xxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVL-PT--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxx-xR----- ----xxxxxxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx---------------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxxxxxxxxE--E-DRQ-- --S----------------------------------------------- -------SGESVDFNxxx-xxx-------xxx------------------ ------------------------------EDDEE--------------- -------------------------------------------------- -----------------------------------PPRILFYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKHQKYPFWPAV-------------------------- ----------VKSVRRREKKASVLFIEGHMDPK-GRGITVSLRRLKHFDC KEKQALLNEAKVDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGDP-E--EPVVGSPQGR-RRPY------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------GHLRAI LKNRKPSRWLKTFLNSGQYLTCMETYLEDEEQLDLVVKYLQGV-Y-QETG SRTLARINGDRVRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAIAAVDAVDYKTAEEKYLKGPS----- ---------------------------------------LSYR----EKE IFDNQLLEExS---Qx---------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSVVUP00000031405 -------------------------------------------------- ----Mx-DA-QYVLCRWEQRLWPAKVLARTEMSTKN--KRKKGVFLSVQI LSLDEKIEVRSTEVEILKTAHIERIASSL---ASQGEVPAEPLEELAYRR SLRVALDVLNQRTGLPP-E------------------------------- ------SSSREE-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxx-xxxxxxxxxxxxxxxxxxxxxx--------- -------------------------------------------------- --------------------xxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KExxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNLAxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxx--xxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxAVL-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxx-xRPCPDG SQRLPATQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx-------------xxxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxx-xxxxxxE--E-DRQ-- --S----------------------------------------------- -------SGDSMEFNxxx-xxx-------xxx------------------ ------------------------------EDDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKHQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGHMDPK-GRGITVSLKRLKHFDC KEKQELLNEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKEDP-E--EPVAGSPQGR-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------GHLRAI LKNRKPSRWLNTFLSSGQYMTCVETYLEDEEQLDLVVKYLQGV-Y-QETG SRTLARVNGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAIAAVDAVDYKTAEEKYLRGPS----- ---------------------------------------LGYR----EKE IFDKQLLEERS---QRC--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSCAFP00000028879 -------------------------------------------------- ----Mx-DA-QYVLCRWEQRLWPAKVLARTETSTKN--KRKKGVFLSVQI LSLDEKIEVRSTEVEILKTAHIERIASSL---ASQGEVPAEPLEELAYRR SLRVALDVLNQRTGLPP-E------------------------------- ------SSSREE-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxx-xxxxxxxxxxxxxxxxxxxxxx--------- -------------------------------------------------- --------------------xxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KExxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RSLAxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- --------------------------------xxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxx--xxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxAVL-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxx-xRPCPDG SQRLPATQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx-------------xxxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxx-xxxxxxE--E-DRQ-- --S----------------------------------------------- -------SGDSMEFNxxx-xxx-------xxx------------------ ------------------------------EDDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKHQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGHMDPK-GRGITVSLKRLKHFDC KEKQELLNEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKEDP-E--EPVAGSPQGR-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------GHLRAI LKNRKPSRWLNTFLSSGQYMTCVETYLEDEEQLDLVVKYLQGV-Y-QETG SRTLARVNGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAIAAVDAVDYKTAEEKYLRGPS----- ---------------------------------------LGYR----EKE IFDKQLLEERS---QRC--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSPPRP00000018805 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTEVATKN--KRKKEFFLSVQI LSLDEKIEVRSTEVEALRVAHIERIASTL---ASQNEVPAEPLEELAYRR SLRVALDVLNESTGLPQ-E------------------------------- ------SPSREE-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxx-xxxxxxxxxxxxxxxxxxxxxx--------- -------------------------------------------------- --------------------xxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KExxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RSSAxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------x-xx----------------- --------------------------------xxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxx--xxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTGS-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxx-xRPCPDS GQRPPAARLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx-------------xxxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xx---------------xxxxxxxxxxxxxxxx-----------xxxx xxxxxxxSGESVERVxxx-xxx-------xxx------------------ ------------------------------EDEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKHQKYPFWPAV-------------------------- ----------VKSVRRREKKASVLFIEGHMDPK-GRGITVSLRRLKHFDC KEKQELLNEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGDP-E--EPVTGSPQGR-RRPR------- -RKVLPDRSRAARDRANQKLVEYIVKARGAExxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxLVVKYLQGVYQETGSRALARGAGGHLRAI LRNRKPSRWLKTFLNSGQYVTCVETYLEDEEQLDLVVKYLQGV-Y-QETG SRALARINADRIRFVLDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAIAAVDAVDYETAEAKYLRGPS----- ---------------------------------------LSYR----EKE MFDNQLLEERS---QRC--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSFCAP00000008744 x------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTEVATKT--KRKKEFFLSVQI LSLDEKIKVRSTEVEALKMAHIERIASTL---ASQNEVPAEPLEELAYRR SLRVALDVLNESTGLPQ-E------------------------------- ------SPSREE-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxx-xxxxxxxxxxxxxxxxxxxxxx--------- -------------------------------------------------- --------------------xxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KExxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RSVAxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------x-xx----------------- --------------------------------xxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxx--xxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTGP-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xxxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxx-xRPRPDS GQRPPAARLxxxxxxxxxx------------------------------- xxx------xxxxxxxxx-------------------------------- ---------------------------xxxxxxxxxx------------- -----------x-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxSGESVERAxxx-xxx-------xxx------------------ ------------------------------EDEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKHQKYPFWPAV-------------------------- ----------VKSVRRREKKASVLFIEGHMDPK-GRGITVSLRRLKHFDC KEKQELLNEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSNGDP-E--EPVAGSPQGR-RRPR------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------GHLRAI LRNRKPSRWLKTFLNSGQYVTCVETYLEDEEQLDLVVKYLQGV-Y-QETG SRALARINADRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAIAAVDAVDYETAEAKYLRGPS----- ---------------------------------------LSYR------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSMPUP00000008267 -------------------------------------------------- ----Mx-DA-QYVLCRWEQRLWPAQVLARTETSTGS--KRKKEFSLSVQI LSLDEKIEVRSTDVETLKTAHIERIASSL---ASQDAVRAEPLEELAYRR SLRVALDVLNQRAALPR-E------------------------------- ------SSSREG-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxx-xxxxxxxxxxxxxxxxxxxxxx--------- -------------------------------------------------- --------------------xxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxx---------------- -----------------------------------------xxxxxxxxx xxxxxxxxxxxxxx---------------xxx------------------ --------------------------------------xxxxxxxxxxxx xxxxxxxxxxxxxxxxx-xxxxx---------------x----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxx--xxxxxx---------xxxxxxxx------- ----------------------------------------------xxx- -----------------------------------xxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxx-xRLxPDG SQRLPAPQLxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx---------------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxx-xxxxxxE--E-DRQ-- --S----------------------------------------------- -------SGESVELNxxx-xxx-------xxx------------------ ------------------------------EDDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKHQKYPFWPAV-------------------------- ----------VKSVRRREKKASVLFIEGHMDPK-GRGITVSLRRLKHFDC KEKQALLNEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGDP-E--EPVAGSPQGR-RRPY------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------GHLRAI LKNRKPSRWLKTFLASGQYVTCVETYLEDEQQLDVVVKYLQGL-Y-QEAG GRAPARASGDTIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAIAAVDAVDYKTAEEKYLRGPS----- ---------------------------------------LSYR----EKE IFDNQLLEERN---QRx--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSEASP00005031817 -------------------------------------------------- ----Mx-DA-KYVLCRWKKRLWPAKVLARPEASTKN--KRKKEFFLNVEI ISLDKKIRVKSTRVKILKKFHIEDIASSL---ASQHEVPAEALEELAYRR SLRVALDVLNERTSCHR-E------------------------------- ------SSSREA-------------------------------------- ---------------------------------------------xT-x- ------------xx-xxx-xxxxxxxxxxxx--------xxxxxx----- -------------------------------------------------- ---------------xxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSAxxx--xx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxx--xxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTLL-LA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------x---x -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxx-xQQCPDG SQRP---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxxxxx-xLE--E-DRP-- --S----------------------------------------------- -------SEESVQFNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPK-GKGITVCLRRLKHFDC KEKHALLSEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGHE-E--EPAAGSPQGR-RPPC------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------SHLRAI LRDRKPSRWLQTFLNSGQYMTCMETYLEDEEQLDLVVKYLQGL-F-QETG SRMLARINGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----Axxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSECAP00000020407 -------------------------------------------------- ----Mx-DA-KYVLCRWKKRLWPAKVLARPEASTKN--KRKKEFFLNVEI ISLDKKIRVKSTRVKILKKFHIEDIASSL---ASQHEVPAEALEELAYRR SLRVALDVLNERTSCHR-E------------------------------- ------SSSREA-------------------------------------- ---------------------------------------------xT-x- ------------xx-xxx-xxxxxxxxxxxx--------xxxxxx----- -------------------------------------------------- ---------------xxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSAxxx--xx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxx--xxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxALL-LA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------x---x -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxx-xQQCPDG SQRP---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxxxxx-xLE--E-DRP-- --S----------------------------------------------- -------SEESVQFNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPK-GKGITVCLRRLKHFDC KEKHALLSEAKEDFDQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLSKGHE-E--EPAAGSPQGR-RPPC------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------SHLRAI LRDRKPSRWLQTFLNSGQYMTCMETYLEDEEQLDLVVKYLQGL-F-QETG SRMLARINGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYIKGPS----- ---------------------------------------LSYR----EKQ IFDNQLLEERS---RRS--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSMLUP00000003101 x------------------------------------------------- ----Mx-DA-KYVLCRWKERLWPAKVLARTEMST-x--KKKKRFFLNVQI LSLDKKVRVKSTEAKILRKSHIEDIAALL---ASQNKVSAKPVEELTYRR SLRVALDILNEKTHSHQ-E------------------------------- ------NSSREE-------------------------------------- ---------------------------------------------xTAx- ------------xx-xxx-xxxxxxxxxxxx--------xxxxxx----- -------------------------------------------------- ---------------xxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxx-xx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNLAxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxx-----------------------------------xxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x x--------xxxx-------------------------xx-xx------- -------------------------------------------------- ----------------xxxxxxxx-------------------------- -------------------------------------------------- --------------------------------xxxxxxxxxx-xQLCSGG SQRx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxx------ -----------------xxxxxxx--------------xxx--E-DHQ-- --S----------------------------------------------- -------SEESMEFDxxx-xxx-------xxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PSSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKNVKRREKKASVLFIEGHMDPK-GRGITVPLKRLKHFDC KEKQALLNEAKEDFDQAIGWCVSLITDYRVRLGCGSFSGSFLEYYAANIS YPVRKSIQQDVLGTRFPRLCHEDP-E--MPLAGSPWGR-RQPC------- -RKVLPDRSRAARDRANQKLVEYIVKTRGAE------------------- --------------------------------------------NHLRAI LKNRKPSRWLQTFLNSGQYVTCVETYLEDEEQLDLVVKYLQGV-Y-RETG SRMLTQINGDQIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDKVDYKTAEKKYIKGPL----- ---------------------------------------LSYR----EKE MFDNQLLEERN---QR---------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSDNOP00000032964 x------------------------------------------------- ----Mx-DA-KYVLCRWKKRLWPAKVLFRSEMSTKN--KRKKEFFLDVQI LSLDEKIKVKSTEVKILKKSQIEDIASLL---ATQNKVTASPLEELAYRR SLRVALDVLNERARSNQ-E------------------------------- ------SSSREE-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxx-xxxxxxxxxxxx--------xxxxxx----- -------------------------------------------------- ---------------xxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSAxxxxxxx xxxxxx-xxxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- --------xxxxxxx----------------------------------- ---xxxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxAVL-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxx------ ----x--------------------------------------------x -------------------------------------------------- -------------------------------------------------- -----------------------x-------------------------- -------------------------------------------------- -----------------------xxxxxxx-------------xRLCPDS SQRPPAWEGxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxx-------------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxxxxxx-xxxxxx----------------------------- -------------------------------------------------- --ADRTGDLR---------------------------------------- ----------------------------------xLxSx----------- --------------------------------------RAE--E-DHQ-- --S----------------------------------------------- -------SGESVEFNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVKRREKKASVLFIEGNMNPK-GKGFTVSLRRLKHFDC KEKQILLDKAREAFSQAIGWCISLITDYRVRLGCASFTGSFLEYYAADIS YPVRKSIQQDVLGTKFPQLSKGDP-N--EPVEGTPLGKxRQPH------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LRSRKPSRWLTTFLNSSQYVTCVETYLEDEEQLERVVKYLQGV-Y-QETD SRVLTRINGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDEVDYKTAEEKYIRGPS----- ---------------------------------------LSYR----EKE IFDNQLLEERS---RRR--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSODEP00000016891 -------------------------------------------------- ----Mx-DA-KYVLCRWEERLWPAKVLDGPKTSTND--KGRKEFFLDVQI LSLDEKLSVKSTEVETLNKSQIESIASSL---ALQTEVPTAALQELTYRR SLRVALDVLNEGSGLSW-E------------------------------- ------STSRRN-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxxxxxxxxxxx---------------------xx xxxxxxxxxxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KRxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------xxx-------------------------------------xxx xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RSLAxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------xxxxxx xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVV-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRMxL-- --RLPATQLxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxxx xxxxxxx----------------------------------------x-- --x-------------------------------xxxxxxxxxxxxx--- -------SQELVEFNxxx-xxx-----xxxxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVKRREKKASVLFIERDMNPK-GRGITVSLRRLKHFDC KEKQALLDKAREDFDQAIGCCVSLITDYRVRLGCGSFAGSFLEYFAADIS YPVRKSIQQNAEGTRFPQLSRGDP-E--EPEGSSPLEW-RLPC------- -RKVLPDRSRAARDRANQRLVEYIVKARGAE------------------- --------------------------------------------SHLHAI LKHGKPSRWLKMFLSSGQYVMCLETYLEDEEQLDRVVKYLQGV-Y-QDVD GDELVQASGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDSVDYKTAEEKYIRGPS----- ---------------------------------------LGYR----EKQ IFDNQVLEERS---RRH--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSFDAP00000018917 -------------------------------------------------- ----Mx-DA-KYVLCRWEERLWPAKVLDGPKTSTND--KGEKEFFLDVQI LSLDEKIKVKSTEVETLKKSQIENIASLL---ASQREVPTAPLKELTYRR SLRVALDILNERSSLSL-E------------------------------- ------STSRQN-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxxxxxxxxxxx---------------------xx xxxxxxxxxxxxxxxxx--------------------------------- ----------x--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------xxxxx-----------------------------------xxx xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------KSAAxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------xxxxxx xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxT-x-xA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRLCL-- --KPPATQLxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxxx xxxxxxxxxxxxxxxx-xx-------------------SLE--E-DPQ-- --A----------------------------------------------- -------SQERTEFNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRILFYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVKRREKKASVLFIEKDMNPK-GRGITVSLRRLKHFDC KEKQALLDKAKEDFDQAIGCCISLITDYRVRLGCGSFAGSFLEYFAADIS YPVRKSIQQDAEGTRFPQLSSGDP-E--EPEGSSPLGW-RRPC------- -RKVLPDRSRAARDRANQKLVEYIVKARGTE------------------- --------------------------------------------SHLHAI LKSGKPSRWLKMFLSSGQYVTCMETYLEDEEQLDHVVKYLQGV-Y-QDMD GEKLVRASGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYLKGPS----- ---------------------------------------LGYR----EKQ IFDNQVLEERS---RRH--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSHGLP00100001773 -------------------------------------------------- ----Mx-DA-KYVLCRWEERLWPAKVLDGPKTS-xD--EGEKEFFLDVQI LSLDEKIKVKSTEVETLKKSQIENIASLL---ASQTEVPTAPLKELTYRR SLRVALDILNERSSSSLxx------------------------------- ------xxxxxx-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxxxxxxxxxxx---------------------xx xxxxxxxxxxxxxxxxx--------------------------------- ----------x--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------EGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------xxxxx----------------------------------xxxx xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNVAxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------xxxxxx xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxT-x-xA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRLCL-- --RPPSTQLxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxxx xxxxxxxxxxxxxxxx-xx-------------------RLE--E-DPQ-- --A----------------------------------------------- -------SQECTEFNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRILFYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVKRREKKASVLFIERDMNPK-GRGITVSLRRLKHFDC KEKQALLDKAKEDFDQAIGCCISLITDYRVRLGCGSFTGSFLEYFAADIS YPVRKSIQQDAEGTRFPQLSRADP-E--EPEGNSPLGW-RRPC------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------SHLHAI LKSGKPSRWLKMFLSSGQYVTCMETYLEDEEQLDRVVKYLQGV-Y-QDMD GDKLARASGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYLKGPS----- ---------------------------------------LGY-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx >ENSHGLP00000010078 -------------------------------------------------- ----Mx-DA-KYVLCRWEERLWPAKVLDGPKTS-xD--EGEKEFFLDVQI LSLDEKIKVKSTEVETLKKSQIENIASLL---ASQTEVPTAPLKELTYRR SLRVALDILNERSSSSLxE------------------------------- ------STSRRN-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxxxxxxxxxxx---------------------xx xxxxxxxxxxxxxxxxx--------------------------------- ----------x--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------EGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------xxxxx----------------------------------xxxx xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNVAxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------xxxxxx xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxT-x-xA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRLCL-- --RPPSTQLxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxxx xxxxxxxxxxxxxxxx-xx-------------------RLE--E-DPQ-- --A----------------------------------------------- -------SQECTEFNxxx-xxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------PPRILFYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVKRREKKASVLFIERDMNPK-GRGITVSLRRLKHFDC KEKQALLDKAKEDFDQAIGCCISLITDYRVRLGCGSFTGSFLEYFAADIS YPVRKSIQQDAEGTRFPQLSRADP-E--EPEGNSPLGW-RRPC------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------SHLHAI LKSGKPSRWLKMFLSSGQYVTCMETYLEDEEQLDRVVKYLQGV-Y-QDMD GDKLARASGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYLKGPS----- ---------------------------------------LGY-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx >ENSCLAP00000011444 -------------------------------------------------- ----Mx-DA-KYVLCRWEERLWPAKVLDGPKTSTNN--KGEKESFLIVQI LSLDEKIKVKSAEVETLKKSQIESIASSL---ASQNEVPTAPLKELTYRR SLRVALDILNEGSSLNQ-E------------------------------- ------STSRRN-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxxxxxxxxxxx---------------------xx xxxxxxxxxxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------xxxxx-----------------------------------xxx xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNLAxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------xxxxxx xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVV-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRLCL-- --RPPATQLxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- -xxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxxx xxxxxxxxxxxxxxxx-xx-------------------RLE--E-DAQ-- --A----------------------------------------------- -------FQEHMEFNxxx-xxx-------xxx------------------ ------------------------------DDDEE--------------- -------------------------------------------------- -----------------------------------PPRILFYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVKRREKKASVLFIERDMNPK-GRGITVSLKRLKHFDC KEKQALLDKAREDFDQAIGCCVSLITDYRVRLGCGSFAGSFLEYFAADIS YPVRKSIQQDAEGTRFPQLSGGDP-K--EPEGDSPLGW-SLPC------- -RKVLPDRSRAARDRANQKLVEYIVKARGAE------------------- --------------------------------------------SHLHAI LKNGKPSRWLKMFLGSGQYATCMETYLEDEEQLDRVVKYLQGV-Y-QDMD GDRLARASGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYLKGPS----- ---------------------------------------LGYR----EKQ IFDNQVLEERS---RRH--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSCAPP00000003349 -------------------------------------------------- ----Mx-DA-KYVLCRWEERSWPAKVLDGPKTSTND--KGEKETFLDVQI LSLDEKLSVKSTEVETLKKSQIEKIASCL---ASQHEVPAAPLEELTYRR SLRVALDVLNEDSS------------------------------------ -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxx-xxxxxxxxxxxx---------------------xx ----------------xxxxxxxxx------------------------- --xxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------KGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------xxxxx-----------------------------------xxx xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------KNLAxxxxxxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------xxxxxx xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxTVV-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x----------------------------------------xx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xR----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------------------------- ----------------------------------xxxxxxxxx------- ---------------------------------xxxxxx---------xx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxxxxxxxxxxxx-------------------RLE--E-DLQ-- --A----------------------------------------------- -------SQEQPEFNxxx-xxx--------xx------------------ ------------------------------xEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVKRREKKASVLFIERDMNPK-GRGITVSLRRLKHFDC KEKQALLDKAREDFDQAIGCCVSLITDYRVRLGCGSFAGSFLEYFAADIS YPVRKSIQQDAKGTRFPQLSRGDP-E--EPEGNSPLGW-QRPC------- -KKVLPDRSRAARDRANQKLVEYIVKTRGAE------------------- --------------------------------------------SHLHAI LKNGKPSRWLKMFLSSGQYVTCMETYLEDEEQLERVVKYLQGV-Y-QDMD GDKLARARGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYIKGPS----- ---------------------------------------LGYR----EKQ IFDNQVLEERS---RRH--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSLAFP00000011261 -------------------------------------------------- ----Mx-DA-KYVLCRWKKRLWPAKVLARTERSTKN--KRKKEFFLDVQI LSLDEKMKVKSTGVEILKKSRIEDIASLL---ASQNEALATPLQELTYRR SLRVALDVLNEGASSSQ-E------------------------------- ------SPSREE-------------------------------------- ---------------------------------------------xxxx- ------------xx-xxx-xxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxx-------------------------- -------------------------------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------RNSAxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx---xx--------------xxxx------xxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- --------------------------------------xxx--------- ----------------xxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x--------------------------------------------- -------------------------------------------------- ---x---------------------------------------------- -----------------------xxx------------------------ -------------------xxxxxxxx----------------------- ---------------------------------------xxx-xRRxLGG RQRP---------------------------------------------- -----------------xxxx----------------------------- -----------------xxxxxxxxxxx---------------------- -----------------------------xxx------------------ -------------------------------------------------- ----------------------------------xx----xxxxxxxxxx x-------xxxxxx--x-----xx--------xx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------E-GRQ-- --A----------------------------------------------- -------SEGSVELGxxx-xxx-------xxx------------------ -------------------------------EDEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSLRRRDKKASVLFIEGNMNPK-GRGITVSLRRLKHFDC KEKQTLLDKAKQDFEQDVGWCVSLITDYRVRLGCGSFSGSFLEYYAAAIS YPVRKSIQQDVLGARFPQLSGGDP-E--EPEAESPLGR-SHRC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LKSRKPSRWLKTFLNSGQYVTCVETYLEDEEQLDLVVKYLQGV-Y-QETG STVLTRVNGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVDAVDYKTAEEKYIKGPS----- ---------------------------------------LSYR----EKE IFDNQVLEERS---RRH--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSMUSP00000020365 -------------------------------------------------- ----Mx-DA-KYVLCRWGKRLWPAKVLARTETSAKN--KKKKEFFLDVQI LSLKEKIQVKSSAVEALQKSHIENIAAFL---ASQNEVPATPLEELTYRR SLRVALDVLNERTSLS---------------------------------- -------------------------------------------------- -xxxxxxxx------------------------------------xxxx- ------------xx-xxx-------------------------------- ------------------------xxxxxxxxxxx--------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-xxxxxxxxxx xxxxxxxxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxx---------xxx---------------- -------------------------------------------------- -------------------------------------------------- ----x--------------------------------------------- -------------------------------------------------- ---x-xxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRPRLDG GQNPPTRQL----------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxx----------xxx------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxx-------------------Kxx--x-DPV-- --S----------------------------------------------- -------SEESTGFKxxx-xxx------xxxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPK-GRGITVSLRRLKHFDC KEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-E--EPVGDSQLGQ-WRPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LHSRKPSRWLKTFLSSSQCVTCMETYLEDEAQLDEVVEYLQGV-C-RDMD GQVPERGSGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVEAVDYKTAEQKYIRGPT----- ---------------------------------------LSYR----EKE IFDNELLEERN---RRR--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >MGP_SPRETEiJ_P0025035 -------------------------------------------------- ----Mx-DA-KYVLCRWGKRLWPAKVLARTETSAKN--KKKKEFFLDVQI LSLKEKIQVKSSAVEALQKSHIENIAAFL---ASQNEVPATPLEELTYRR SLRVALDVLNERTSLS---------------------------------- -------------------------------------------------- -xxxxxxxx------------------------------------xxxx- ------------xx-xxx-------------------------------- ------------------------xxxxxxxxxxx--------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-xxxxxxxxxx xxxxxxxxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxx---------xxx---------------- -------------------------------------------------- -------------------------------------------------- ----x--------------------------------------------- -------------------------------------------------- ---x-xxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRPRLDG GQNPPTSQL----------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxx----------xxx------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxx-------------------Kxx--x-DPV-- --S----------------------------------------------- -------SEESTGFKxxx-xxx------xxxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPK-GRGITVSLRRLKHFDC KEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-E--EPVGDSQLGQ-WRPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LHSRKPSRWLKTFLSSSQCVTCMETYLEDEAQLDEVVEYLQGV-C-RDMD GQVPERGSGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVEAVDYKTAEQKYIRGPT----- ---------------------------------------LSYR----EKE IFDNELLEERN---RRR--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSMSIP00000007736 -------------------------------------------------- ----Mx-DA-KYVLCRWGKRLWPAKVLARTETSAKN--KKKKEFFLDVQI LSLKEKIQVKSSAVEALQKSHIENIAAFL---ASQNEVPATPLEELTYRR SLRVALDVLNERTSLS---------------------------------- -------------------------------------------------- -xxxxxxxx------------------------------------xxxx- ------------xx-xxx-------------------------------- ------------------------xxxxxxxxxxx--------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-xxxxxxxxxx xxxxxxxxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxx---------xxx---------------- -------------------------------------------------- -------------------------------------------------- ----x--------------------------------------------- -------------------------------------------------- ---x-xxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRPRLDG GQNPPTRQL----------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxx----------xxx------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxx-------------------Kxx--x-DPV-- --S----------------------------------------------- -------SEESTGFKxxx-xxx------xxxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAVxEAERHRQGRGLLLRDQDGSLAWWHT PVILSHMEFKVKSVRRRDKKASVLFIEGNMNPK-GRGITVSLRRLKHFDC KEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-E--EPVGDSQLGQ-WRPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LHSRKPSRWLKTFLSSSQCVTCMETYLEDEAQLDEVVEYLQGV-C-RDMD GQVPERGSGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVEAVDYKTAEQKYIRGPT----- ---------------------------------------LSYR----EKE IFDNELLEERN---RRR--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >MGP_CAROLIEiJ_P0023880 -------------------------------------------------- ----Mx-DA-KYVLCRWGKRLWPAKVLARTETSAKN--KRKKEFFLDVQI LSLKEKIQVKSSAVEALQKSHIENIAAFL---ASQNEVPATPLEELTYRR SLRVALDVLNERTSLS---------------------------------- -------------------------------------------------- -xxxxxxxx------------------------------------xxxx- ------------xx-xxx-------------------------------- ------------------------xxxxxxxxxxx--------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-xxxxxxxxxx xxxxxxxxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxx---------xxx---------------- -------------------------------------------------- -------------------------------------------------- ----x--------------------------------------------- -------------------------------------------------- ---x-xxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRPRFDG GQNPPTRQQ----------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxx----------xxx------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxx-------------------Kxx--x-DPV-- --S----------------------------------------------- -------SEESTGFKxxx-xxx------xxxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPK-GRGITVSLRRLKHFDC KEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-E--EPVGDSQLGQ-WRPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LHSRKPSRWLKTFLSSSQCVTCMETYLEDEAQLDEVVEYLQGV-C-RDMD GQVPERGSGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVEAVDYKTAEQKYIRGPT----- ---------------------------------------LSYR----EKE IFDNELLEERN---RRR--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >MGP_PahariEiJ_P0087034 -------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSAKN--KRKKEFFLDVQI LSLKEKIQVKSSAVEALQKSHIENIAAFL---ASQNEVPATPLEELTYRR SLRVALDILNERTSLS---------------------------------- -------------------------------------------------- -xxxxxxxx------------------------------------xxxx- ------------xx-xxx-------------------------------- ------------------------xxxxxxxxxxx--------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-xxxxxx-xxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxx---------xxx---------------- -------------------------------------------------- -------------------------------------------------- ----x--------------------------------------------- -------------------------------------------------- ---x-xxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRPRLDG GQNPPTRQL----------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxx----------xxx------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxx-------------------Kxx--x-DPV-- --S----------------------------------------------- -------SEEPTGFKxxx-xxx-------xxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPK-GRGITVSLRRLKHFDC KEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-X--EPVGDSQLGQ-WRPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LHSRKPSRWLKTFLSSSQCVTCMETYLEDEAQLDEVVEYLQGV-C-RDMD GQVPERGSGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVEAVDYKTAEQKYIRGPT----- ---------------------------------------LSYR----EKE IFDNELLEERN---RRR--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSRNOP00000057438 -------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSAKN--KRKKEFFLDVQI LSLKEKIQVKSSAVEALQKSHIENIAAFL---ASQNEVPATPLEELTYRR SLRVALDVLNERTSLS---------------------------------- -------------------------------------------------- -xxxxxxxx------------------------------------xxxx- ------------xx-xxx-------------------------------- ------------------------xxxxxxxxxxx--------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-xxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxx---------xxx---------------- -------------------------------------------------- -------------------------------------------------- ----x--------------------------------------------- -------------------------------------------------- ---x-xxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRPRLDG GRNPLPRHL----------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxx----------xxx------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxx-------------------Rxx--xxDPM-- --S----------------------------------------------- -------SEESTGFKxxx-xxxxxxxxxxxxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPK-GRGITVSLRRLKHFDC KEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-E--EPMGDSRLGQ-WRPC------- -RKVLPDRSRAARDKANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LHSRKPSRWLKTFLSSNQYVTCMETYLEDEAQLDEVVEYLQGV-C-RDMD GEMPARGSGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVEAVDYKTAEQKYLRGPT----- ---------------------------------------LSYR----EKE IFDNELLEERN---RRR--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSMUGP00000024715 -------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLARTETSAKN--KRKKELFLDVQI LSLKEKIQVKSSAVEALQKSHIENIAAFL---ASQNEVPATPLEELTYRR SLRVALDVLNERGSLS---------------------------------- -------------------------------------------------- -xxxxxxxx------------------------------------xxxx- ------------xx-xxx-------------------------------- -----------------------------------xx------------- ---------------------------------------------xxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- ----xxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------TAxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-x xxxx---------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxx-xx-xx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRPRLDS GQNPPTRQL----------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxx----------xxx------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxx-------------------Kxx--x-DPV-- --S----------------------------------------------- -------SEESTGLKxxx-xxx------xxxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPK-GRGITVSLRRLKHFDC KEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-E--APAGDSQPGQ-WRPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LHSRKPSRWLKMFLSSGQYVTCVETYLEDEAQLDEVVGYLQGI-C-RDMD GEVPASGSGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAIAAVESVDYKTAEQKYIRGPT----- ---------------------------------------LSYR----EKE IFDNELLEERS---RRR--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSCGRP00015006556 -------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLAITETSVKN--RRKKELFLDVQI LSLKEKIQVKSSAVEALQKSHIENIAAFL---ASQNEVPAAPLEELTYRR SLRVALDLLNERTNLS---------------------------------- -------------------------------------------------- -xxxxxxxx------------------------------------xxxx- ------------xx-xxx-------------------------------- ------------------------xxxxxxxxxxx--------------- -------------------------------------------------- ------xx------------------------------------------ -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------TGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxRLL-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRPRLDG GQNPQARQL----------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxx----------xxx------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxx-------------------Kxx--x-DPV-- --S----------------------------------------------- -------SEESTGFKxxx-xxx------xxxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPK-GRGITVSLRRLKHFDC KEKHTLLERAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS HPVRKSIQQDVLGTRFPQLGKGD-xE--EPVGDSRPGQ-WRPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LHSRKPSRWLKTFLSSGQYVTCVETYLEDEAQLDEVVEYLQGI-C-RDMD GEVPARGSGDRIRFVLDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVESVDYKTAEQKYIRGPT----- ---------------------------------------LSYR----EKE IFDNELLEERN---RRR--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSCGRP00001014056 -------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLAITETSVKN--RRKKELFLDVQI LSLKEKIQVKSSAVEALQKSHIENIAAFL---ASQNEVPAAPLEELTYRR SLRVALDLLNERTNLS---------------------------------- -------------------------------------------------- -xxxxxxxx------------------------------------xxxx- ------------xx-xxx-------------------------------- ------------------------xxxxxxxxxxx--------------- -------------------------------------------------- ------xx------------------------------------------ -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------TGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxRLL-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRPRLDG GQNPQARQL----------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxx----------xxx------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxx-------------------Kxx--x-DPV-- --S----------------------------------------------- -------SEESTGFKxxx-xxx------xxxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPK-GRGITVSLRRLKHFDC KEKHTLLERAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS HPVRKSIQQDVLGTRFPQLGKGD-xE--EPVGDSRPGQ-WRPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LHSRKPSRWLKTFLSSGQYVTCVETYLEDEAQLDEVVEYLQGI-C-RDMD GEVPARGSGDRIRFVLDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVESVDYKTAEQKYIRGPT----- ---------------------------------------LSYR----EKE IFDNELLEERN---RRR--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSCGRP00000018891 -------------------------------------------------- ----Mx-DA-KYVLCRWEKRLWPAKVLAITETSVKN--RRKKELFLDVQI LSLKEKIQVKSSAVEALQKSHIENIAAFL---ASQNEVPAAPLEELTYRR SLRVALDLLNERTNLS---------------------------------- -------------------------------------------------- -xxxxxxxx------------------------------------xxxx- ------------xx-xxx-------------------------------- ------------------------xxxxxxxxxxx--------------- -------------------------------------------------- ------xx------------------------------------------ -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------TGxxxxx----------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxRLL-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRPRLDG GQNPQARQL----------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxx----------xxx------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxx-------------------Kxx--x-DPV-- --S----------------------------------------------- -------SEESTGFKxxx-xxx------xxxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPK-GRGITVSLRRLKHFDC KEKHTLLERAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS HPVRKSIQQDVLGTRFPQLGKGD-xE--EPVGDSRPGQ-WRPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LHSRKPSRWLKTFLSSGQYVTCVETYLEDEAQLDEVVEYLQGI-C-RDMD GEVPARGSGDRIRFVLDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVESVDYKTAEQKYIRGPT----- ---------------------------------------LSYR----EKE IFDNELLEERN---RRR--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSMAUP00000016093 -------------------------------------------------- ----Mx-DA-QYVLCRWEKRLWPAKVLAITETSVKN--RRKKELFLDVQI LSLKEKIQVKSSAVEALQKSHIENIAAFL---ASQNEVPAAPLEELAYRR SLRVALDLLNERTSLG---------------------------------- -------------------------------------------------- -xxxxxxxx------------------------------------xxxx- ------------xx-xxx-------------------------------- ------------------------xxxxxxxxxxx--------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------ -------------------xxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxRLL-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRPRLDG GQNPPASQL----------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxx----------xxx------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxx-------------------Kxx--x-DPV-- --S----------------------------------------------- -------SEESTGFKxxx-xxx------xxxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGTMNPK-GRGITVSLRRLKHFDC KEKHTLLERAKEDFSQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDPxx--EPVGDSQPGQ-WRPC------- -RKVLPDRSRAARDKANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LHSRKPSRWLKTFLSSGQYVTCVETYLEDEAQLDEVVGYLQGV-C-RDMD GEVPARGSGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVESVDYKTAEQKYIRGPT----- ---------------------------------------LSYR----EKE IFDNELLEERS---RRR--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSPEMP00000027994 -------------------------------------------------- ----Mx-DA-KYVLCQWEKRLWPAKVLARTETSAKN--KRKKELFLEVQI LSLKEKIQVKSSAVEKLQKSHIENIAAFL---ASQNDVPATPLEELAYRR SLRVALDILNERTSLS---------------------------------- -------------------------------------------------- -xxxxxxxx------------------------------------xxxx- ------------xx-xxx-------------------------------- ------------------------xxxxxxxxxxx--------------- -------------------------------------------------- ------xx------------------------------------------ -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xx-------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------- ---xxxxx---------xxxxxxxx------------xx----------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxx---------xxxx----------- -------------------------------------------------- --------------------------------------xxxKLL-PA--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRPRLDG GQNPPARQL----------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxx----------xxx------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxx-------------------Kxx--x-DLV-- --S----------------------------------------------- -------SEESTGFKxxx-xxx------xxxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------PPRILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDRKASVLFIEGNMNPK-GRGITVSLRRLKHFDC KEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDVLGTRFPQLGKGDP-E--EPVGDSRPGQ-WRPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAV LCSRKPSRWLKTFLTSGQYVTCVETYLEDEAQLDEVVEYLQDI-C-RDMD GEVPARGGGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAISAVESVDYKTAEQKYIRGPT----- ---------------------------------------LSYR----EKE IFDNELLEERN---RRR--------------------------------- -------------------------------------------------- ----------------------------xx-------------------- --x-------------------------------------------- >ENSNGAP00000023751 -------------------------------------------------- ----Mx-DA-QYVLCKWEKRLWPAKVLSRTEMATKN--KTKKEFFLEVQI LSLKEKIQVKSSAVEVLQKSHIENIATFL---ASQNEVPAAPLEELTYRR SLRVALDILNQTTSLSQ-E------------------------------- ------xxx----------------xxxxxxx-----------------x xx------------------------------------------------ ---------------xxx-------------------------------- ------------------------xxxxxxxxxxxxxxxxxxxxxxxxxx xxx---------------------------------xxxxxxxxxx---- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x---------------xxxxx------- ------------------------xx------------------------ -------------------------------------------------- -------------------------------------------------- --------------------TGxxxxxx---------------------- ------------------------------------------xxxxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxxxx------------------------ --------------------------------------xxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxx-xRPRPDA GQNPPTMQLx---------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxxxxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxx-------------------Rxx--xxDPP-- --S----------------------------------------------- -------PEKSEEFSxxx-xxx-----xxxxx------------------ ------------------------------DEDEE--------------- -------------------------------------------------- -----------------------------------PPQILLYRE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEVGMLVWLKYQKYPFWPAV-------------------------- ----------VKSVRRRDKKASVLFIEGNMNPK-GRGITVSLRRLKHFDC SEKHMLLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADIS YPVRKSIQQDLLGTRFPQLGKGNP-E--KPLGDSPLGQ-WRPC------- -RKVLPDRSRAARDRANQKLVEYIVKAKGAE------------------- --------------------------------------------SHLRAI LHSRKPSRWLKTFLSSGQYVTCVETYLEDEGQLDEVVEYLQGV-C-RDMD GEVPAQGSGDRIRFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAIAAVDAVDYKTAEQKYIQGPT----- ---------------------------------------LSYR----EKE IFDNELLEERS---RRR--------------------------------- -------------------------------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSSHAP00000016424 -------------------------------------------------- ----Mx-DT-QYVLCRWKKRLWPAKVLPQTGLSTRKxxQKMRSAFLNVEI LSLDKKIKVKKTETKILEKSQIEEIAAEL---TTQVEIKTTPKEELIYRR SLKFGLDVLSQKADAIE--------------------------------- -------------------------------xxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------x------------------------ -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxxxxx xxxxxxxxxxxx--------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- ----x----------------------------------------xxxxx -------------------------------------------------- -xxx---------------------------------xxxxx-------- --xxxxxxxx-----------xxx-------------------------- --------------------------xxxx-------------------- -------------xxxxxxxxxxx-------------------------- -------------------------------------------------- --------------xxxx-------------------------------- -----------------------------xxxx----------------- -----------------------------xxx------------------ -------------------------------------------------- ---------------------------------xxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----KTRTLK---------------------------------------- ----------------------------------LPxFx----------- --------------------------------------DDE--E-ELQ-- --S----------------------------------------------- -------SEQSLEFSxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPSILSRPE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCSIEAGMLVWCKYQKYPYWPSV-------------------------- ----------VKSVKRKDKKASILYIEGNMNPE-KRGFTVSLRRLKHFDC EEKQELMDKAKEDYSQGVDWCIMLISDYRIRIGCGSFVGSFLEYYSADIS CPVRKVIQQAPIKTVFPILNKEEP-E--DGLSDTSLxK-KQSF------- -KKVLPDRRRAARDKANEKLVEYIVNEKGAE------------------- --------------------------------------------NHLLAI LKSRKKSRWLKEFLNSSQYMTCVETYLEDDEQLYLVVKYLQEV-Y-QEID SKMLTLINGDGIKFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYAISAIDEIDYQTAEKKYIEGPS----- ---------------------------------------VSKR----ERE MFDKELLEEKK---KEL--------------------------------- -------------------------------------------------- -------xxx---xxxxxxxxxx--------------------------x xxxx------------------------------------------x >ENSPCIP00000014324 -------------------------------------------------- -----x-DT-QYVLCRWRERLWPAKVLSQTGISRRQxxRKRKAAFLEVEI LSLDEKIKVKKTETRILEKSQIEDIAAEF---STQVKIKTTPIEELIYRR SLKVALDILSQKADASQ--------------------------------- -------------------------------xxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------x------------------------ -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxxxxx xxxxx-xxxxxx--------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- ----x----------------------------------------xxxxx -------------------------------------------------- -xxx---------------------------------xxxxx-------- --xxxxxxxx-----------xxx-------------------------- --------------------------xxxx-------------------- -------------xxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------------------------- ---------------------------------xxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----KSRALK---------------------------------------- ----------------------------------xPxFx----------- --------------------------------------EDE--E-ELQ-- --A----------------------------------------------- -------SEWSLEFSxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPSILSHPE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCSIEAGMLVWCKYQKYPYWPAV-------------------------- ----------VKSIKRKDKKASILYIEENMNPE-KKGFIVCLRRLKYFDC EEKRELVDKAKEDYSQAVDWCIKLISDYRIRIGCGSFAGSFLEYYSADIS VPVRKGMRQAPIKTVFPILNKEDP-E--DGLPDTSLxK-KLLF------- -KKVLPDRRRAARDKANEKLVEYIVNEKGAE------------------- --------------------------------------------NHLLAI LKSRKKSRWLKEFLDSSQYMKCVETYLEDDEQLDLVVKYLQGI-Y-QEID SKMLKLINGDGIKFILNVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------VIYAISATDEIDYQTAEEKYIKGPS----- ---------------------------------------VSKR----ERE MFDKELLExxx---xx---------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSMODP00000006402 -------------------------------------------------- ----Mx-DT-EYVLCRWEKRLWPAKVLPQTGISRRHxxQKRKAAFLDVEI LSLDKKIKVKKTEIKALEKSHIEEIASEF---ITQVAINTPVTEELIYRR SLKAAMDILDQKADASQ--------------------------------- -------------------------------xxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxx----xxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxx--------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------x------------------------ -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxx------------------ ----xx-------------------------------------------- --------------------------xxxxx------------------- ---xx--------------------------------------------- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxxx xxxxxxxxxxxx--------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- ----x----------------------------------------xxxxx -------------------------------------------------- -xxx---------------------------------xxxxx-------- --xxxxxxxx-----------xxx-------------------------- --------------------------xxxx-------------------- -------------xxxxxxxxxxx-------------------------- -------------------------------------------------- --------------xxxx-------------------------------- -----------------------------xxxx----------------- -----------------------------xxx------------------ -------------------------------------------------- ---------------------------------xxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----KTRILK---------------------------------------- ----------------------------------xPxFx----------- --------------------------------------EDE--E-ELQ-- --S----------------------------------------------- -------SEESLEFSxxxxxxx-------xxx------------------ ------------------------------DEDEE--------------- -------------------------------------------------- -----------------------------------LPSILLYHE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCSIEAGMLVWCKYQKYPYWPAV-------------------------- ----------VKSVMRKDKKASILYIEENMNPK-KRGFTVGLRRLKHFDC EEKQELMDKAKEDYSQAVDWCITLISDYRVRIGCGSFTGSFLEYYSADIS CPVRKVIQQESNKTMFPIPNKEDS-E--DGLPETPTxK-KQPF------- -KKVLPDRMRAARDKANEKLVEYIVNEKGAE------------------- --------------------------------------------NHLLAI LKSRKESKWLKEFLNSSQYVTCVETYLEDDEQLDLVVKYLQGV-Y-QEID SKMLTLINGDRIKFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYAISVIDQIDYQKAEEKYIKGPS----- ---------------------------------------LSER----ERE IFNKELLEKKK---GTF--------------------------------- -------------------------------------------------- -------x------------------------------------------ xxx-------------------------------------------- >ENSMUSP00000109754 -------------------------------------------------- ----M--xxxEYVLCGWKSQLCPARVLSRPRTPAHS--KRRGVPFLEVQI LPVGEKRRVRSSKVRPLAKSEIISINSLA---GKESRGRGSPGQTRASRR ALKVALDGLGEGSSF----------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxx-xxxxxx ------------x---xxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxxxxxxxxxx-------xxxxxxxx xxxxxx---xxxx------xx--xxxx------xxxxxxxxxxxxxxxxx x-------------xxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxx---------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxx------------ ----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------- ----------xxxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xISISP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxQxxxx----------------------- --------xxxxxxxxxxxxxxxx-------------------------- ----x--------------------------------------------- ----x-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIASRKKKTHxxxxx-----------------------------xxxxxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------QKDAK--------------- -------------------------------------------------- -----------------------------------ATNVVSAQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PSTIEQGTLVWFKFQDLPFWPAV-------------------------- ----------VKSVSKIDKMARVLLIEGNMQFE-RRGIRVPLRKLKHLDC GEKVSLVRRASRLYAQGINWCFSVIDHYREGLSRGSLLGSFMDYYTTQAS YPLRRAVQEGDLHIDFPKVSYAEL-E--DWEEETALGG-KGPY------- -KKLLPDRMRAAWDRANQKLVDFIVKRKGAD------------------- --------------------------------------------QHLLDI VKGRKPSRWLDDLWKSKREVFCIETYLEDDDQLHLVARHLQEV-A-KEAD EALLSLARGDKVRFTMEVLFP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYSIAALDELSYKEAEEKYLRGPP----- ---------------------------------------VHYR----EKE LFDKTILKAAR---KRS--------------------------------- -----------------------xAx------------------------ xxx-------------xxxxxxx--------------------------- -xx-------------------------------------------- >ENSMUSP00000109751 -------------------------------------------------- ----M--xxxEYVLCGWKSQLCPARVLSRPRTPAHS--KRRGVPFLEVQI LPVGEKRRVRSSKVRPLAKSEIISINSLA---GKESRGRGSPGQTRASRR ALKVALDGLGEGSSF----------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxx-xxxxxx ------------x---xxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxxxxxxxxxx-------xxxxxxxx xxxxxx---xxxx------xx--xxxx------xxxxxxxxxxxxxxxxx x-------------xxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxx---------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxx------------ ----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------- ----------xxxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xISISP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxQxxxx----------------------- --------xxxxxxxxxxxxxxxx-------------------------- ----x--------------------------------------------- ----x-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIASRKKKTHxxxxx-----------------------------xxxxxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------QKDAK--------------- -------------------------------------------------- -----------------------------------ATNVVSAQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PSTIEQGTLVWFKFQDLPFWPAV-------------------------- ----------VKSVSKIDKMARVLLIEGNMQFE-RRGIRVPLRKLKHLDC GEKVSLVRRASRLYAQGINWCFSVIDHYREGLSRGSLLGSFMDYYTTQAS YPLRRAVQEGDLHIDFPKVSYAEL-E--DWEEETALGG-KGPY------- -KKLLPDRMRAAWDRANQKLVDFIVKRKGAD------------------- --------------------------------------------QHLLDI VKGRKPSRWLDDLWKSKREVFCIETYLEDDDQLHLVARHLQEV-A-KEAD EALLSLARGDKVRFTMEVLFP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYSIAALDELSYKEAEEKYLRGPP----- ---------------------------------------VHYR----EKE LFDKTILKAAR---KRS--------------------------------- -----------------------xAx------------------------ xxx-------------xxxxxxx--------------------------- -xx-------------------------------------------- >ENSMUSP00000085806 -------------------------------------------------- ----M--xxxEYVLCGWKGQLWPARVLSRPRTPANS--KRRGAPFLEVQI LPVGEKMRVRSSEVRPLDKSEIISIASLA---GKESRGRGSPGQTRAYRR ALKVALDVLGEGTSL----------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxx-xxxxxx ------------x---xxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxxxx--------------------- ---------------------------------xxxxxxxxxxxxxxxxx x-------------xxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxx---------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxx------------ ----------xxxxxxxx-xxxxxxxxxxxxxxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xISISP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxKxxxx----------------------- --------xxxxxxxxxxxxxxxx-------------------------- ----x--------------------------------------------- ----E-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIASQKKKPHxxxxx-----------------------------xxxxxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------QKDAK--------------- -------------------------------------------------- -----------------------------------ATNVASAQG------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PSTIERGTLVWFKFQDLPFWPAV-------------------------- ----------VKSVSENDKMARVLLIEGNMQFE-RRGIRVPLRKLKHLDC GEKVSLVRRASRLYAQGINWCFSVIDHYREGLAHGSFLGSFMDYYTTQAS YPLRRAVQEGDLHIDFPKVSYAEL-E--DWEEETALGG-KGPY------- -KKLLPDRMRAAWDRANQKLVDFIVKRKGAD------------------- --------------------------------------------QHLLDI VKGRKPSRWLDDLWKSKREVFCIETYLEDEDQLHLVARHLQEV-A-KEAD EALLSLARGDKVRFTMEVLFP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDELTYKEAEEKYLRGPP----- ---------------------------------------VHYR----EKE LFDKTILKAAR---KRS--------------------------------- -----------------------xAx------------------------ xxx-------------xxxxxxx--------------------------- -xx-------------------------------------------- >ENSMUSP00000079200 -------------------------------------------------- ----M--xxxEYVLCGWKGQLWPARVLSRPRTPANS--KRRGAPFLEVQI LPVGEKMRVRSSEVRPLDKSEIISIASLA---GKESRGRGSPGQTRAYRR ALKVALDVLGEGTSL----------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxx-xxxxxx ------------x---xxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxxxx--------------------- ---------------------------------xxxxxxxxxxxxxxxxx x-------------xxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxx---------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxx------------ ----------xxxxxxxx-xxxxxxxxxxxxxxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xISISP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxKxxxx----------------------- --------xxxxxxxxxxxxxxxx-------------------------- ----x--------------------------------------------- ----x-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIASQKKKPHxxxxx-----------------------------xxxxxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------QKDAK--------------- -------------------------------------------------- -----------------------------------ATNVASAQG------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PSTIERGTLVWFKFQDLPFWPAV-------------------------- ----------VKSVSENDKMARVLLIEGNMQFE-RRGIRVPLRKLKHLDC GEKVSLVRRASRLYAQGINWCFSVIDHYREGLAHGSFLGSFMDYYTTQAS YPLRRAVQEGDLHIDFPKVSYAEL-E--DWEEETALGG-KGPY------- -KKLLPDRMRAAWDRANQKLVDFIVKRKGAD------------------- --------------------------------------------QHLLDI VKGRKPSRWLDDLWKSKREVFCIETYLEDEDQLHLVARHLQEV-A-KEAD EALLSLARGDKVRFTMEVLFP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDELTYKEAEEKYLRGPP----- ---------------------------------------VHYR----EKE LFDKTILKAAR---KRS--------------------------------- -----------------------xAx------------------------ xxx-------------xxxxxxx--------------------------- -xx-------------------------------------------- >ENSRNOP00000060281 -------------------------------------------------- ----M--xxxEYVLCGWKGQLWPARVLSRPRTPAHS--KRRGTPFLEVQI LPVGEKMRVRSTEVRPLTKSEIISIASxx---xxxx--RGSPGQSRAYRR ALKVALDVLGEGTCL----------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxx-xxxxxx ------------x---xxxxxxxx-x------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxxxxxxxx----------------- -----------------------------------xxxxxxxxxxxxxxx x-------------xxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxx---------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxx------------ ----------xxxxxxxx-xxxxxxxxxxxxxxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xISVSP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxQxxxx----------------------- --------xxxxxxxxxxxxxxxx-------------------------- ----x--------------------------------------------- ----E-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIASRKRKVRxxxxx-----------------------------xxxxxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------PKDAQ--------------- -------------------------------------------------- -----------------------------------ATNVASAQG------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PSTIERGTLVWFKFQDLPFWPAV-------------------------- ----------VKSVSTIDKMARVLLIEGNMQFE-RRGIRVPLRKLKHLDC GEKISLLRRARRLYAHGINWCFSVIDHYREELACGSFLGSFIDYFTTQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETTPGG-KGPH------- -KKFLPDRMKAAWDRANQKLVDFIVKRKGAD------------------- --------------------------------------------QHLMDI VKGRKPSKWLDALWKSKREVLCIETYLEDEDQLHLVARHLQEV-A-KEAD KALLSLARGDIVRFTMEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIANLDELSYKEAEEKYLRGPP----- ---------------------------------------VHYR----EKE LFDKNILKAAR---KRS--------------------------------- -----------------------xAx------------------------ xxx-------------xxxxxxx--------------------------- -xx-------------------------------------------- >ENSRNOP00000023222 -------------------------------------------------- ----M--xxxEYVLCGWKGQLWPARVLSRPRTPAHS--KRRGTPFLEVQI LPVGEKMRVRSTEVRPLTKSEIISIASxx---xxxx--RGSPGQSRAYRR ALKVALDVLGEGTCL----------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxx-xxxxxx ------------x---xxxxxxxx-x------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxxxxxxxx----------------- -----------------------------------xxxxxxxxxxxxxxx x-------------xxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxx---------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxx------------ ----------xxxxxxxx-xxxxxxxxxxxxxxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xISVSP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxQxxxx----------------------- --------xxxxxxxxxxxxxxxx-------------------------- ----x--------------------------------------------- ----x-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIASRKRKVRxxxxx-----------------------------xxxxxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------PKDAQ--------------- -------------------------------------------------- -----------------------------------ATNVASAQG------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PSTIERGTLVWFKFQDLPFWPAV-------------------------- ----------VKSVSTIDKMARVLLIEGNMQFE-RRGIRVPLRKLKHLDC GEKISLLRRARRLYAHGINWCFSVIDHYREELACGSFLGSFIDYFTTQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETTPGG-KGPH------- -KKFLPDRMKAAWDRANQKLVDFIVKRKGAD------------------- --------------------------------------------QHLMDI VKGRKPSKWLDALWKSKREVLCIETYLEDEDQLHLVARHLQEV-A-KEAD KALLSLARGDIVRFTMEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIANLDELSYKEAEEKYLRGPP----- ---------------------------------------VHYR----EKE LFDKNILKAAR---KRS--------------------------------- -----------------------xAx------------------------ xxx-------------xxxxxxx--------------------------- -xx-------------------------------------------- >ENSCGRP00015001742 -------------------------------------------------- ----M--xxxEYVLCSWKGQMWPARVLSRPRTSSHS--KRRGASFLEVQI LPVGEKTRVRSTEVRPLTRSEIVTIASLA---GKESQGNGSPRQTRAYRR ALKVALDVLGEGTCL----------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx ------------x---xxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- xxxx-------------------------------xxxxxxxxxxxxxxx x-------------xxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxx---------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxx------------ ----------xxxxxxxx-xxxxxxxxxxxxxxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xASTSP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxQxxxx----------------------- --------xxxxxxxxxxxxxxxx-------------------------- ----x--------------------------------------------- ----x-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIASRKRKVHxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------Q--------------- -------------------------------------------------- -----------------------------------ATNVASAQG------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PNTIERGMLVWFKFQDLPFWPAV-------------------------- ----------VKSVNKNDKMARVLLIEGNMQFE-HKGVRVPLRKLKHLDC GEKSVLLRRASRVYGQAINWCLSVINHYREVLACGSFLGSFMDYYTAQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETALGG-KGPR------- -KKLLPDRMRAAWDRANQKLVDFIVKRKGAD------------------- --------------------------------------------QHLLDI VKGRKPSRWLDNLWKSKREVFCIETYLEDEDQLHLVARHLQEI-S-NEAD EALLSLARGDKVRFTMEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDELSYKEAEEKYLRGPP----- ---------------------------------------VHHR----EKE LFDKTILKAAR---KRS--------------------------------- -----------------------xAx------------------------ xxx-------------xxxxxxx--------------------------- -xx-------------------------------------------- >ENSCGRP00000026564 -------------------------------------------------- ----M--xxxEYVLCSWKGQMWPARVLSRPRTSSHS--KRRGASFLEVQI LPVGEKTRVRSTEVRPLTRSEIVTIASLA---GKESQGNGSPRQTRAYRR ALKVALDVLGEGTCL----------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx ------------x---xxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- xxxx-------------------------------xxxxxxxxxxxxxxx x-------------xxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxx---------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxx------------ ----------xxxxxxxx-xxxxxxxxxxxxxxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xASTSP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxQxxxx----------------------- --------xxxxxxxxxxxxxxxx-------------------------- ----x--------------------------------------------- ----x-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIASRKRKVHxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------Q--------------- -------------------------------------------------- -----------------------------------ATNVASAQG------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PNTIERGMLVWFKFQDLPFWPAV-------------------------- ----------VKSVNKNDKMARVLLIEGNMQFE-HKGVRVPLRKLKHLDC GEKSVLLRRASRVYGQAINWCLSVINHYREVLACGSFLGSFMDYYTAQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETALGG-KGPR------- -KKLLPDRMRAAWDRANQKLVDFIVKRKGAD------------------- --------------------------------------------QHLLDI VKGRKPSRWLDNLWKSKREVFCIETYLEDEDQLHLVARHLQEI-S-NEAD EALLSLARGDKVRFTMEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDELSYKEAEEKYLRGPP----- ---------------------------------------VHHR----EKE LFDKTILKAAR---KRS--------------------------------- -----------------------xAx------------------------ xxx-------------xxxxxxx--------------------------- -xx-------------------------------------------- >ENSCGRP00015003500 -------------------------------------------------- ----M--xxxEYVLCSWKGQMWPARVLSRPRTSSHS--KRRGASFLEVQI LPVGEKTRVRSTEVRPLTRSEIVTIASLA---GKESQGNGSPRQTRAYRR ALKVALDVLGEGTCL----------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx ------------x---xxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- xxxx-------------------------------xxxxxxxxxxxxxxx x-------------xxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxx---------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxx------------ ----------xxxxxxxx-xxxxxxxxxxxxxxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xASTSP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxQxxxx----------------------- --------xxxxxxxxxxxxxxxx-------------------------- ----x--------------------------------------------- ----x-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIASRKRKVHxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------Q--------------- -------------------------------------------------- -----------------------------------ATNVASAQG------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PNTIERGMLVWFKFQDLPFWPAV-------------------------- ----------VKSVNKNDKMARVLLIEGNMQFE-HKGVRVPLRKLKHLDC GEKSVLLRRASRVYGQAINWCLSVINHYREVLACGSFLGSFMDYYTAQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETALGG-KGPR------- -KKLLPDRMRAAWDRANQKLVDFIVKRKGAD------------------- --------------------------------------------QHLLDI VKGRKPSRWLDNLWKSKREVFCIETYLEDEDQLHLVARHLQEI-S-NEAD EALLSLARGDKVRFTMEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDELSYKEAEEKYLRGPP----- ---------------------------------------VHHR----EKE LFDKTILKAAR---KRS--------------------------------- -----------------------xAx------------------------ xxx-------------xxxxxxx--------------------------- -xx-------------------------------------------- >ENSCGRP00015003495 -------------------------------------------------- ----M--xxxEYVLCSWKGQMWPARVLSRPRTSSHS--KRRGASFLEVQI LPVGEKTRVRSTEVRPLTRSEIVTIASLA---GKESQGNGSPRQTRAYRR ALKVALDVLGEGTCL----------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx ------------x---xxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- xxxx-------------------------------xxxxxxxxxxxxxxx x-------------xxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxx---------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxx------------ ----------xxxxxxxx-xxxxxxxxxxxxxxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xASTSP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxQxxxx----------------------- --------xxxxxxxxxxxxxxxx-------------------------- ----x--------------------------------------------- ----x-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIASRKRKVHxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------Q--------------- -------------------------------------------------- -----------------------------------ATNVASAQG------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PNTIERGMLVWFKFQDLPFWPAV-------------------------- ----------VKSVNKNDKMARVLLIEGNMQFE-HKGVRVPLRKLKHLDC GEKSVLLRRASRVYGQAINWCLSVINHYREVLACGSFLGSFMDYYTAQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETALGG-KGPR------- -KKLLPDRMRAAWDRANQKLVDFIVKRKGAD------------------- --------------------------------------------QHLLDI VKGRKPSRWLDNLWKSKREVFCIETYLEDEDQLHLVARHLQEI-S-NEAD EALLSLARGDKVRFTMEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDELSYKEAEEKYLRGPP----- ---------------------------------------VHHR----EKE LFDKTILKAAR---KRS--------------------------------- -----------------------xAx------------------------ xxx-------------xxxxxxx--------------------------- -xx-------------------------------------------- >ENSCGRP00015005143 -------------------------------------------------- ----M--xxxEYVLCSWKGQMWPARVLSRPRTSSHS--KRRGASFLEVQI LPVGEKTRVRSTEVRPLTRSEIVTIASLA---GKESQGNGSPRQTRAYRR ALKVALDVLGEGTCL----------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx ------------x---xxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- xxxx-------------------------------xxxxxxxxxxxxxxx x-------------xxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxx---------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxx------------ ----------xxxxxxxx-xxxxxxxxxxxxxxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xASTSP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxQxxxx----------------------- --------xxxxxxxxxxxxxxxx-------------------------- ----x--------------------------------------------- ----x-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIASRKRKVHxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------Q--------------- -------------------------------------------------- -----------------------------------ATNVASAQG------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PNTIERGMLVWFKFQDLPFWPAV-------------------------- ----------VKSVNKNDKMARVLLIEGNMQFE-HKGVRVPLRKLKHLDC GEKSVLLRRASRVYGQAINWCLSVINHYREVLACGSFLGSFMDYYTAQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETALGG-KGPR------- -KKLLPDRMRAAWDRANQKLVDFIVKRKGAD------------------- --------------------------------------------QHLLDI VKGRKPSRWLDNLWKSKREVFCIETYLEDEDQLHLVARHLQEI-S-NEAD EALLSLARGDKVRFTMEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDELSYKEAEEKYLRGPP----- ---------------------------------------VHHR----EKE LFDKTILKAAR---KRS--------------------------------- -----------------------xAx------------------------ xxx-------------xxxxxxx--------------------------- -xx-------------------------------------------- >ENSCGRP00001004164 -------------------------------------------------- ----M--xxxEYVLCSWKGQMWPARVLSRPRTSSHS--KRRGASFLEVQI LPVGEKTRVRSTEVRPLTRSEIVTIASLA---GKESQGNGSPRQTRAYRR ALKVALDVLGEGTCL----------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx ------------x---xxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- xxxx-------------------------------xxxxxxxxxxxxxxx x-------------xxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxx---------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxx------------ ----------xxxxxxxx-xxxxxxxxxxxxxxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xASTSP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxQxxxx----------------------- --------xxxxxxxxxxxxxxxx-------------------------- ----x--------------------------------------------- ----x-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIASRKRKVHxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------Q--------------- -------------------------------------------------- -----------------------------------ATNVASAQG------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PNTIERGMLVWFKFQDLPFWPAV-------------------------- ----------VKSVNKNDKMARVLLIEGNMQFE-HKGVRVPLRKLKHLDC GEKSVLLRRASRVYGQAINWCLSVINHYREVLACGSFLGSFMDYYTAQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETALGG-KGPR------- -KKLLPDRMRAAWDRANQKLVDFIVKRKGAD------------------- --------------------------------------------QHLLDI VKGRKPSRWLDNLWKSKREVFCIETYLEDEDQLHLVARHLQEI-S-NEAD EALLSLARGDKVRFTMEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDELSYKEAEEKYLRGPP----- ---------------------------------------VHHR----EKE LFDKTILKAAR---KRS--------------------------------- -----------------------xAx------------------------ xxx-------------xxxxxxx--------------------------- -xx-------------------------------------------- >ENSPEMP00000035164 -------------------------------------------------- ----M--xxxEYVLCGWKGQLWPARVLSRPGTSAHR--KRRGASFLEVQI LPVGEKTRVRSTEARPLTKSETVTIASLA---GKESQGKSSPRQTRAYRK ALKVALDVLGEGTCL----------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxx-xxxxxx ------------x---xxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- xxxx-------------------------------xxxxxxxxxxxxxxx x-------------xxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxx---------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxx------------ ----------xxxxxxxx-xxxxxxxxxxxxxxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xVSTLP-RA--- -------------------------------------------------- -------------------------------------------------- --------------------xxQxxxx----------------------- --------xxxxxxxxxxxxxxxx-------------------------- ----x--------------------------------------------- ----x-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIATRKRKIHxxxxx-----------------------------xxxxxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------QEDRQ--------------- -------------------------------------------------- -----------------------------------ATNVASAQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PSTIERGMLVWFKFQDLPFWPAV-------------------------- ----------VKSVSKNGKMARVLLIEGNMQFE-HRGVRVPLRKLKHLDC GAKLSLLRRASRVYSQGISWCLSVIDHYKEDLACGSFLGSFMDYYTSQAS YPLRRAIQEGDLHIDFPKVSYADL-E--DWEEETALGG-KGPR------- -KKLLPDRMRAAWDRANQKLVDFIVKRKGAD------------------- --------------------------------------------QHLRDI VKGRKPSRWLDDLWKSKREVFCIETYLEDEDQLHLVARHLQEI-S-KEAD EALLSLARGDKVRFTMEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDELSYKEAEEKYLRGPP----- ---------------------------------------VHYR----EKE LFDKTILKAAR---MRS--------------------------------- -----------------------xSx------------------------ xxx-------------xxxxxxx--------------------------- -xx-------------------------------------------- >ENSMUGP00000029457 -------------------------------------------------- ----M--xxxEYVLCGWKGQLWPARVLSRPRISAHS--KRRGAPYLEVQI LPMGEKTRVRSTEVRPLTKSEIVTIASTA---GKESQGSSFPGQTRAYKR ALKVALDILGEGDSL----------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxx-xxTSTx ------------Ax--xxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- xxxx-------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxx---------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxx------------------------xxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xLSTLP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxQxxxx----------------------- --------xxxxxxxxxxxxxxxx-------------------------- ----x--------------------------------------------- ----E-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIASKKRKMHxxxxx-----------------------------xxxxxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------QEGGQ--------------- -------------------------------------------------- -----------------------------------ATKVVSAQL------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PNTIEQGMLVWFKFQDLPFWPAV-------------------------- ----------VKSVSQKDKMASVLLIEGNMQFE-HRGVRVPLHKLKHLDC GEKISLMKRASRMYKHGISWCFSVIDHYREGLACGSFLGSFMDYYTAQAS YPLRRAIQNGDLHIDFPKVSYADL-E--DWEEETALGG-KRPH------- -KKLLPDRMRAAWDRANQKLVDFIVKRKGAD------------------- --------------------------------------------QHLRDI MKGRKQSRWLDKLWKSKKEVFCIETYLEDEEQLHLVARHLQEI-A-KEAD EALLSLTRGDKVRFTMEVLFP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDELSYKKAEEKYLRGPP----- ---------------------------------------VHYR----EKE LFDKTILKAAR---KRP--------------------------------- -----------------------xAx------------------------ xxx-------------xxxxxxx--------------------------- -xx-------------------------------------------- >ENSOARP00000006721 -------------------------------------------------- ----x--DT-RYVLCVWKGRFWPAKVLSRPSVSPQQ--KRKRALSREVQI LSVDEKVRVKKTKMKTLKESMIESISTSL---AAQPEPSAPEEEEMAYIC AITMAWDLLHKNGNVTP-A------------------------------- ------RVTGDPxxxx---------------------------------x xx----------------xxxxxxxxxxxxxxxxxx--------x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xSxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TExxxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xILTVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVSxxxxx-------------------------------- --xxV-xx-xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxx-- --xx---------------------------------------xx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx RLANSKRKLQ---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKEAGQ--------------- -------------------------------------------------- -----------------------------------LTSMAFPEE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -LCPIERGMLVWFKFQNHPFWPAV-------------------------- ----------VTSVSPTEQTARVLLIEANMHCE-KSGIQVPLRRLKHLDY NGKEKLMKRASKVYGESVNWCFSLISSYREGLVRGSFVGSFLDYYAADLS YPMRKAIQEGDLQMDFPKVNYSDL-E--DSEEETPVAA-KRHC------- -KRILPDRMRAARDRANQKLVDFIVKTKGAD------------------- --------------------------------------------PHLLDI VKGRKESKWLESFLNSERYVICVETYLEDDNQLDAVVRHLREI-Y-RHID KRALALTRDDPVSFLLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIATVDGLDYKEAEAKYRQGPP----- ---------------------------------------VHYR----EKE LFDKKILKKIR---KRS--------------------------------- -----------------------xEx------------------------ xxx-------------xxxxxxx--------------------------- -Qx-------------------------------------------- >ENSBBBP00000012806 x------------------------------------------------- ----x--DT-RYVLCVWKGRFWPAKVLSRPSVSPQQ--KRKRALSLEVQI LSIDEKIRVKKTKIKTLKESMIESISTSL---AAQPEPIAPEEEEMAYIC AITMAWDVLNKNGNFTP-A------------------------------- ------RVAGDPxxxx---------------------------------x xx----------------xxxxxxxxxxxxxxxxxx--------x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xSxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TExxxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xILTVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVSxxxxx-------------------------------- --xxV-xx-xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------x------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -LANRKRKLQ---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKEVGQ--------------- -------------------------------------------------- -----------------------------------LTSMACPEE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -LCPIERGMLVWFKFQNHPFWPAV-------------------------- ----------VKSVSPTEQTARVLLIEANMHCE-KSGIQVPLRRLKHLDY NGKEKLMKRASKVYGASVNWCFSLISSYREGLVRGSFVGSFLDYYAADIS YPMRKAIQEGDLQMDFPKVNYSDL-E--DSEEETP----QRHC------- -KRILPDRMRAAWDRANEKLVDFIVNRKGAD------------------- --------------------------------------------PHLLDI VKGRKESKWLESFRNSERYVICVETYLEDDDQLDAVVRHLQEI-Y-KHID KKALALTRDDPVSFLLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIATMDGLDYKEAEAKYRQGPP----- ---------------------------------------VRYR----EKE LFDKKILKKIK---KRS--------------------------------- -----------------------xExxxxxxxxxxxxxxxxxxxxxxxxx -------------------------------------------------- ----------------------------------------------- >ENSBTAP00000032621 -------------------------------------------------- ----x--DT-RYVLCVWKGRFWPAKVLSRPSVSPQQ--KRKRALSLEVQI LSIDEKIRVKKTKIKTLKESMIESISTSL---AAQPEPIAPEEEEMAYIC AITMAWDVLNKNGNFTP-A------------------------------- ------RVAGDPxxxx---------------------------------x xx----------------xxxxxxxxxxxxxxxxxx--------x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xSxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TExxxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xILTVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVSxxxxx-------------------------------- --xxV-xx-xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------x------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -LANRKRKLQ---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKEVGQ--------------- -------------------------------------------------- -----------------------------------LTSMACPEE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -LCPIERGMLVWFKFQNHPFWPAV-------------------------- ----------VKSVSPTEQTARVLLIEANMHCE-KSGIQVPLRRLKHLDY NGKEKLMKRASKVYGASVNWCFSLISSYREGLVRGSFVGSFLDYYAADIS YPMRKAIQEGDLQMDFPKVNYSDL-E--DSEEETPVAA-KRHC------- -KRILPDRMRAAWDRANEKLVDFIVNRKGAD------------------- --------------------------------------------PHLLDI VKGRKESKWLESFLHSERYVICVETYLEDDDQLDAVVRHLQEI-Y-KHID KKALALTRDDPVSFLLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIATMDGLDYKEAEAKYRQGPP----- ---------------------------------------VRYR----EKE LFDKKILKKIK---KRS--------------------------------- -----------------------xExxxxxxxxxxxxxPxACxNSCPSSx -------------------------------------------------- ----------------------------------------------- >ENSBMUP00000031371 x------------------------------------------------- ----x--DT-RYVLCVWKGRFWPAKVLSRPSVSPQQ--KRKRALSLEVQI LSIDEKIRVKKTKIKTLKESMIESISTSL---AAQPEPSAPEEEEMAYIC AITMAWDVLNKNGNFTP-A------------------------------- ------RVAGDPxxxx---------------------------------x xx----------------xxxxxxxxxxxxxxxxxx--------x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xSxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TExxxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xIFTVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVSxxxxx-------------------------------- --xxV-xx-xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------x------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -LANRKRKLQ---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKEVGQ--------------- -------------------------------------------------- -----------------------------------LTSMACPEE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -LCPIERGMLVWFKFQNHPFWPAV-------------------------- ----------VKSVSPTEQTARVLLIEANMHCE-KSGIQVPLRRLKHLDY NGKEKLMKRASKVYGASVNWCFSLISSYREGLVRGSFVGSFLDYYAADIS YPMRKAIQEGDLQMDFPKVNYSDL-E--DSEEETPVAA-KRHC------- -KRILPDRMRAAWDRANEKLVDFIVNRKGAD------------------- --------------------------------------------PHLLDI VKGRKESKWLESFLNSERYVICVETYLEDDDQLDAVVRHLQEI-Y-KHID KKALALTRDDPVSFLLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIATMDGLDYKEAEAKYRQGPP----- ---------------------------------------VRYR----EKE LFDKKILKKIK---KRS--------------------------------- -----------------------xExxxxxxxxxxxxxPxACxNSCPSSx -------------------------------------------------- ----------------------------------------------- >ENSVVUP00000002542 -------------------------------------------------- ----x--DA-NYVLCNWKGHLWPARVLSRSGVSPRN--KRKGALSLEVEI LSVVEKIKVKSTDVKILNESQIESITSLL---TAQSKASVPAGQEAPYRN ALTMPLEILKERADVRP-G------------------------------- ------GASDGPx------------------------------------- ----------------------------------------------TTxx ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx x-------------xxxxxxxxxxxxxx---------------------- -------------------------------------------------- ------------------xxxRxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------AKxxxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xNLTVPxxA--- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxx------------------------ ---------------------xxx-------------------------- ----x--xxPAASxxxxx-------------------------------- --xxG-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RLANRRRKLQ---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxQEMGQ--------------- -------------------------------------------------- -----------------------------------VTSTLSPQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCPIEGGMMVWFKFQNHPFWPAV-------------------------- ----------VKSVSQAEQTARVLLIEANMHAE-MSGIRVPLRRLKPLDC IEKETLMKRARKVYEQSVNWCFSLISHYREGLTCGSFAGSFLDYYSADVS YPVRKAIQDGDLEADFPKVNYADL-E--DYEEETSVGG-KRPP------- -KKILPDRMRAAWDRANQRLVDFIVKTKGAD------------------- --------------------------------------------HHLLDI VKGRKQSRWLTSFLNSNRYTLCIETYLEDEDQLDVVVGHLQEI-Y-KQID KKRLSLAREDKVSFVVEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDGLGYKEAEAKYLRGPP----- ---------------------------------------VHYW----EKE LFDKSILKKMR---KRS--------------------------------- -----------------------xxx------------------------ xxx------------xx--------------------------------- ----------------------------------------------- >ENSVVUP00000041787 -------------------------------------------------- ----x--DA-EYVLCNWKGHLWPARVLSRPGVSPRN--KRKGALSLEVEI LSVDEKIKVKSTDVKILNESQIESITSLL---TAQSKASVPAGQEAPYRN ALTMPLEILKERADVRP-G------------------------------- ------GASDGPx------------------------------------- ----------------------------------------------TTxx ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx x-------------xxxxxxxxxxxxxx---------------------- -------------------------------------------------- ------------------xxxRxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------AKxxxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xNLTVPxxA--- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxx------------------------ ---------------------xxx-------------------------- ----x--xxPAASxxxxx-------------------------------- --xxG-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RLANRRRKLQ---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxQEMGQ--------------- -------------------------------------------------- -----------------------------------VTSTLSPQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCPIEGGMMVWFKFQNHPFWPAV-------------------------- ----------VKSVSQAEQTARVLLIEANMHAE-MSGIRVPLRRLKPLDC IEKETLMKRARKVYEQSVNWCFSLISHYREGLTCGSFAGSFLDYYAADVS YPVRKAIQDGDLEAEFPKVNYADL-E--DSDEETSVGG-KRPR------- -QKILPDRMRAARDRANQRLVDFIVKRKGAD------------------- --------------------------------------------HHLLDI VKGKKQSRWLTSFLNSKRYTLCIETYLEDEDQLDVVVGHLQEI-Y-KQID RKRLTLARDDKVSFVVEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDGLGYKEAEEKYLQGPP----- ---------------------------------------VHYR----EKQ LFDNNILKQMR---KRS--------------------------------- -----------------------xxx------------------------ xxx------------xx--------------------------------- ----------------------------------------------- >ENSCAFP00000040849 -------------------------------------------------- ----x--DA-EYVLCNWKGHLWPARVLSRSGVSPRN--KRKGALSLEVEI LSVDEKMKVKSTDVKILNESQIESITSLL---TAQSKASVPAGQEVPYRN ALSVALEILKERADVRP-A------------------------------- ------GASDDPx------------------------------------- ----------------------------------------------TTxx ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx x-------------xxxxxxxxxxxxxx---------------------- -------------------------------------------------- ------------------xxxRxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------AKxxxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xNLTVPxxA--- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxx------------------------ ---------------------xxx-------------------------- ----x--xxPAASxxxxx-------------------------------- --xxR-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RLANRRRKLQ---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxQEMGQ--------------- -------------------------------------------------- -----------------------------------LTSTLSPQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCPIEGGMMVWFKFQNHPFWPAV-------------------------- ----------VKSVSQAEQTARVLLIEANMHAE-MSGIRVPLRRLKPLDF KEKETLMKRARKMYEQSVNWCFSLISHYREGLTCGSFAGSFLDYYAADVS YPVRKAIQDGDLEADFPKVNYADL-E--DSEEETSVGG-KRPR------- -KKILPDRMRAARDRANQRLVDFIVKTKGAD------------------- --------------------------------------------HHLLDI VKGRKQSRWLTSFLNSNRYTLCVETYLEDEDQLDVVVGHLQEI-Y-KQID KKRLTLARDDKVSFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDGLGYKEAEEKYLRGPP----- ---------------------------------------VHYR----EKE LFDKNILKKMR--------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSCAFP00000035555 -------------------------------------------------- ----x--DA-EYVLCNWKGHLWPARVLSRSGVSPRN--KRKGALSLEVEI LSVDEKIKVKSTDVKILNESQIESITSLL---TAQSKASVPAGQEVPYRN ALSVALEILKERADVRP-A------------------------------- ------GASDDPx------------------------------------- ----------------------------------------------TTxx ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx x-------------xxxxxxxxxxxxxx---------------------- -------------------------------------------------- ------------------xxxRxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------AKxxxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xNLTVPxxA--- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxx------------------------ ---------------------xxx-------------------------- ----x--xxPAASxxxxx-------------------------------- --xxR-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RLANRRRKLQ---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxQEMGQ--------------- -------------------------------------------------- -----------------------------------LTSTLSPQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCPIEGGMMVWFKFQNHPFWPAV-------------------------- ----------VKSVSQAEQTARVLLIEANMHAE-MSGIRVPLRRLKPLDC KEKETLMKRARKMYEQSVNWCFSLISHYREGLTCGSFAGSFLDYYAADVS YPVRKAIQDGDLEADFPKVNYADL-E--DSEEETSVGG-KRPR------- -KKILPDRMRAARDRANQRLVDFIVKTKGAD------------------- --------------------------------------------HHLLDI VKGRKQSRWLTSFLNSNRYTLCVETYLEDEDQLDVVVGHLQEI-Y-KQID KKRLTLARDDKVSFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDGLGYKEAEEKYLRGPP----- ---------------------------------------VHYR----EKE LFDKNILKKMR--------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSCAFP00000031828 -------------------------------------------------- ----x--DA-EYVLCNWKGHLWPARVLSRSGVSPRN--KRKGALSLEVEI LSVDEKIKVKSTDVKILNESQIESITSLL---TAQSKASVPAGQEVPYRN ALTVALEILKERADVCP-A------------------------------- ------GASDDPx------------------------------------- ----------------------------------------------TTxx ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx x-------------xxxxxxxxxxxxxx---------------------- -------------------------------------------------- ------------------xxxRxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------AKxxxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xNLTVPxxA--- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxx------------------------ ---------------------xxx-------------------------- ----x--xxPAASxxxxx-------------------------------- --xxR-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RLVNRRRKLQ---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxQEMGQ--------------- -------------------------------------------------- -----------------------------------LTSTLSPQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCPIEGGMMVWFKFQNHPFWPAV-------------------------- ----------VKSVSQAEQTARVLLIEANMHAE-MSGIRVPLRRLKPLDF KEKETLMKRARKMYEQSVNWCFSLISHYREGLTCGSFAGSFLDYYAADVS YPVRKAIQDGDLEADFPKVNYADL-E--DSEEETSVGG-KRPR------- -KKILPDRMRAARDRANQRLVDFIVKKKGAD------------------- --------------------------------------------HHLLDI VKGRKQSRWLTSFLNSKRYTLCIETYLEDEDQLDVVVGHLQEI-Y-KQID KKRLTLARDDKVSFVVEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDGLGYKEAEEKYLRGPP----- ---------------------------------------VHYR----EKQ LFDKNILKKMR---KRS--------------------------------- -----------------------xxx------------------------ xxx------------xx--------------------------------- ----------------------------------------------- >ENSCAFP00020014518 xx------------------------------------------------ ----x--DA-EYVLCNWKGHLWPARVLSRSGVSPRN--KRKGALSLEVEI LSVDEKMKVKSTDVKILNESQIESITSLL---TAQSKASVPAGQEVPYRN ALSVALEILKERADVRP-A------------------------------- ------GASDDPx------------------------------------- ----------------------------------------------TTxx ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx x-------------xxxxxxxxxxxxxx---------------------- -------------------------------------------------- ------------------xxxRxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------AKxxxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xNLTVPxxA--- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxx------------------------ ---------------------xxx-------------------------- ----x--xxPDASxxxxx-------------------------------- --xxG-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RLANRRRKLQ---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxQEMGQ--------------- -------------------------------------------------- -----------------------------------LTSTLSPQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCPIEGGMMVWFKFQNHPFWPAV-------------------------- ----------VKSVSQAEQTARVLLIEANMHAE-MSGIRVPLRRLKPLDC KEKETLMKRARKMYEQSVNWCFSLISHYREGLTCGSFAGSFLDYYAADVS YPVRKAIQDGDLEADFPKVNYADL-E--DSEEETSVGG-KRPR------- -KKILPDRMRAARDRANQRLVDFIVKTKGAD------------------- --------------------------------------------HHLLDI VKGRKQSRWLTSFLNSNRYTLCVETYLEDEDQLDVVVGHLQEI-Y-KQID KKRLTLARDDKVSFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDGLGYKEAEEKYLRGPPxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSMPUP00000018864 -------------------------------------------------- ----x--DA-EYVLCNWKGHVWPAKVLSRARTSPRH--KRKGALFLEVEI LSVDEKIKVKTADTKILNESQIEYVASLL---IAEPKASVPPGQEVPYRN ALAVALEILNERANLGP-A------------------------------- ------RASDDPxxx----------------------------------- --------------------------------------------xxxxxx ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx x-------------xxxxxxxxxxxxxx---------------------- -------------------------------------------------- ------------------xxxRxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------AExxxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xNLTVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVSxxxxx-------------------------------- --xxG-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RLANKKRKLQ---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKEMGQ--------------- -------------------------------------------------- -----------------------------------PISMAFPQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCPIEGGMMVWFKFQNHPFWPAV-------------------------- ----------VKSVSQTEQTARVLLIEANMPCE-TSGIQVPLRRLKHLDC KEKEKLMKRAGKVYEHSVNWCFSLISHYREGLGRGSFAGSFLDYYAADIS YPIRKAIKDGDVEIDFPKVNYADL-E--DSEEEASLGG-RRPH------- -KKILPDRMRAARDRANQKLVDFIVKRKGAD------------------- --------------------------------------------HHLLDI VKGRKQSRWLASFLNSSRYVICIETYLEDEDQLDVVVRHLQEI-Y-KQID KKTLTLARDDKVSFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDGLGYEEAEQKYLKGPP----- ---------------------------------------VHYR----EKE LFDKNIVKGMR---KRA--------------------------------- -----------------------xTx------------------------ xxx-------------x--------------------------------- ----------------------------------------------- >ENSMLUP00000021546 -------------------------------------------------- ----x--DS-EYVLCNWKGRFWPARVLSRSETSPKS--KGKKICSLEVQI LSVGKKVKVKNRDIKILDESQIESITASL---GAQTTARVPPGEGEAYKS ALTIALEILKERANLGA-A------------------------------- ------RASDDPx------------------------------------- ----------------------------------------------TPxx ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx x-------------xxxxxxxxxxxxxx---------------------- -------------------------------------------------- ------------------xxxSxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------GRxxxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xSVTVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxRxxx------------------------ --------------------xxxx-------------------------- ----x--xxLAVSxxxxx-------------------------------- --xxG-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RLAGKVRMHW---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKGVGQ--------------- -------------------------------------------------- -----------------------------------PTSMAFPQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCPIETGMMVWFKFQNHPFWPAV-------------------------- ----------VKSVNHTERTARVLPVEADMHHD-QSGLRVPLRRLKHLEC NAKEKLLKRARKVYEQSVDWCFSLISHYREELARGSFAGSFLDYYAADIS YPLRRAVQEGELYIAFPKVNYADL-E--DSEEESSPGG-RRPR------- -KKILPDRMKAARDRDNQKLVDFIVKRKGAD------------------- --------------------------------------------HHLLDI VKGRKQSRWLTSFLNSSRYVICVETYLEDEDQLDVVMQHLQEI-Y-KHID KNKLSLTRDDKVSFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDGVDYKKAEEKYLRGPP----- ---------------------------------------VHYR----EKE LFDKNILKKIN---KRP--------------------------------- -----------------------xIx------------------------ xxx-------------x--------------------------------- ----------------------------------------------- >ENSMLUP00000013067 -------------------------------------------------- ----x--DS-EYVLCNWKGHFWPARVLSRSETSPKS--KGKKICSLEVQI LAVGKKVKVKNRDIKILDESRIESITSLL---GAQTTARVPPGEGEAYKS ALAIALEILKDRANLGA-A------------------------------- ------RASDDPx------------------------------------- ----------------------------------------------TPxx ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx x-------------xxxxxxxxxxxxxx---------------------- -------------------------------------------------- ------------------xxxSxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------GRxxxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xSVTVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxRxxx------------------------ --------------------xxxx-------------------------- ----x--xxLAVSxxxxx-------------------------------- --xxG-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RLAGKVRKQW---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKGVGQ--------------- -------------------------------------------------- -----------------------------------PTSMAFPQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCPIETGMMVWFKFQNHPFWPAV-------------------------- ----------VKSVNHTERTARVLPVEADMHHD-QSGLQVPLRRLKHLEC NAKEKLLKRARKVYEQSVDWCFSLISHYREELARGSFAGSFLDYYAADIS YPLRRAVQEGELYIAFPKVNYADL-E--DSEEESSPGG-RRPR------- -KKILPDRMKAAWDRDNQKLVDFIVKRKGAD------------------- --------------------------------------------HHLLDI VKGRKQSRWLTSFLNSSRYVICVETYLEDEDQLDVVMQHLQEI-Y-KHID KNKLSLTRDDKVSFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDGVDYKKAEEKYLRGPP----- ---------------------------------------VHYR----EKE LFDKNILKKIS---KRP--------------------------------- -----------------------xIx------------------------ x---------------x--------------------------------- ----------------------------------------------- >ENSCJAP00000072495 -------------------------------------------------- ----x--DS-EYVLCSWKGRLWPAKVLCTRATSPKT--MRQVAPSLEVQI LAVDEKIKVSSTDVRTPTKSEMEDIAASA---AAQRMVGAPPGEKLGYRG TLQVALEMLNERTNLRG-G------------------------------- ------xxxxxxx------------------------------------- ----------------------------------------------xxxx ------------xxxxxxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx----------xxxxxxxxx------- -----------------------------------------------xx- -------------------------------------------------- -------------------------------------------------- --------------------Kxxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxx--xxxxxxxxxxxxTALTPGALCGDSSGE LTAxxxxxxx---------------------------------------- --------------------------------xxxDSS------------ ----------------GELT------------------------------ --------------AxxxxxxxxxGDSSGELTAT---------------- --------------------APxxGALCGDSSGELTATxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxx--------------------------------------------- ---------------------------xxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx- --------------------------------------------xxxxxx TPRMAVAxxPGALRxxxxxxxxxxxxxxxxxxxDSSAARKAIxxx----- -------------------------------------------------- -----------------xxxxxxxxxPARMxxASTPGTLRGDRTDRxxxx -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxHVAIASTPxxxxSDGFQVCxxxxxTPGAMHGDSSTACTA TAPxxxxxxxDRSDRSGKRKATAPTPGPLRTDSSPVPT------------ ----------------------GIAPSPGTxxxxxxxxxxxIASTPGALH SDNTDRSRKRKAIALTPGTLRVDGSPACRAIAPTPGALGSDSSPAHMxxx xxxGALHGDxxxxxxxxAxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx MAIDPTRGTLRGD------------------------------------- -------------------------------------------------- -------------------RSxxxxxxxxxxxxxxxxxxxxTDRSRKRKS IALTPGTLRVDRSPARRDIAPTPGTLGSDRSPAHTNTTPTPGPLGGDRSL AHMAIASTPGALQGDGSQVHTxxxxxxxxxxxxxSTMCMAIAPTPGxxxx DRSRKHKAIAPTPGAPRTDRSQIHTAIAPTPGAQR--------------- -------------------------------------------------- ---------------------------------------V---------- -------------DRSTACKAIAPIPGALGGDGSPARTAMAPTPHALRGD RSRKRKAIAPTPGTLCGDSSPAGRAIAPTPGTLGGDGSP----------- -------------------------AHTAIAPTxxxxxxxxxxxxxxxGP ISxxxxxxxxxxxx-------------------xxxxxxGALHSxRPQTH MAIAPIPGVLCxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------x----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xTSPVP-PA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----xxxxxLAASxxxxx-------------------------------- --xxG-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIAERKRKLP---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKQDGR--------------- -------------------------------------------------- -----------------------------------PAGLALRRE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRPIERGTLVWFKFQDHPFWPAV-------------------------- ----------VKSVSNTDKTARVLLLDDNLHHG-NRGIQVPLQRLKHLDC KEQEKLLKRAQKAYKQSVDWCFSLISHYREGLVRGSFRGSFLDYYAADVS YPVRRAVQEGDLQIDFPKVNYADL-E--DWEEETSLGG-KRPC------- -KKILPDRMRAARDRDNRKLVDFIVREKGAD------------------- --------------------------------------------PHLLDI LQGRKQSRWLTMFLTPHRDLLCFETYLEDDDQLEVVTKHLQEI-YxKQMD KTMLTRIRDDKVNFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAIAATDGLDYKAAEEKYLRGPP----- ---------------------------------------VHYR----EKE LFDRNVLKKRR---RKP--------------------------------- -----------------------xTx------------------------ xxx-------------x--------------------------------- ----------------------------------------------- >ENSCJAP00000077871 -------------------------------------------------- ----x--DS-EYVLCSWKGRLWPAKVLCTRATSPKT--MRQVAPSLEVQI LAVDEKIKVSSTDVRTPTKSEMEDIAASA---AAQRMVGAPPGEKLGYRG TLQVALEMLNERTNLRG-G------------------------------- ------xxxxxxx------------------------------------- ----------------------------------------------xxxx ------------xxxxxxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx----------xxxxxxxxx------- -----------------------------------------------xx- -------------------------------------------------- -------------------------------------------------- --------------------KSxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxx--xxxxDRSPARTPTALTPGALCGDSSGE LTATAPTPGA---------------------------------------- --------------------------------LCGDSS------------ ----------------GELT------------------------------ --------------ATAPTPGALCGDSSGELTAT---------------- --------------------APTPGALCGDSSGELTATxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxTATTPSPGALHGDRSPTHVAIASNPGALH SDGSQARTAIAPTLGAPGSDSSTAGTAIxxxxxALRGGMxxxxxxxxxxx xxxxx--------------------------------------------- ---------------------------xxxxxxxARxxxxPxxxxxxxxx xxxPTGIAPTPGALGGDRSLVHMAVASTQGALQGGSSQTHTNIAPTPGA- --------------------------------------------RHSDSS TPRMAVAPSPGALRxxxxxxxxxxxxxxxxPRVDSSAARKAIAPT----- -------------------------------------------------- -----------------LGALGSDGSPARMAIASTPGTLRGDRTDRSRKH -------------------------------------------------- -------------------------------------------------- --------------------------KAIALTPGTLGSDSSPAPTGIAPS PGALHDDRSPGHVAIASTPGxxxSDGFQVCTTIAPTPGAMHGDSSTACTA TAPTPDALPSDRSDRSGKRKATAPTPGPLRTDSSPVPT------------ ----------------------GIAPSPGTLHGDRSPAHKAIASTPGALH SDNTDRSRKRKAIALTPGTLRVDGSPACRAIAPTPGALGSDSSPAHMNIA RAPGALHGDSSPAHTAIASTxxxxxxxxxxxxxxxxxxxxxxxxxxxMVH MAIDPTRGTLRGD------------------------------------- -------------------------------------------------- -------------------RSxxxxxxxxxAPTPGTLRGDRTDRSRKRKS IALTPGTLRVDRSPARRDIAPTPGTLGSDRSPAHTNTTPTPGPLGGDRSL AHMAIASTPGALQGDGSQVHTxxxxxxxxxxxxxSTMCMAIAPTPGxxxx DRSRKHKAIAPTPGAPRTDRSQIHTAIAPTPGAQR--------------- -------------------------------------------------- ---------------------------------------V---------- -------------DRSTACKAIAPIPGALGGDGSPARTAMAPTPHALRGD RSRKRKAIAPTPGTLCGDSSPAGRAIAPTPGTLGGDGSP----------- -------------------------AHTAIAPTxxxxxxxxxxxxxxxGP ISxxxxxxxxxxxx-------------------xxxxxxGALHSDRPQTH MAIAPIPGVLCxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------x----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xTSPVP-PA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----xxxxxLAASxxxxx-------------------------------- --xxG-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RIAERKRKLP---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKQDGR--------------- -------------------------------------------------- -----------------------------------PAGLALRRE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRPIERGTLVWFKFQDHPFWPAV-------------------------- ----------VKSVSNTDKTARVLLLDDNLHHG-NRGIQVPLQRLKHLDC KEQEKLLKRAQKAYKQSVDWCFSLISHYREGLVRGSFRGSFLDYYAADVS YPVRRAVQEGDLQIDFPKVNYADL-E--DWEEETSLGG-KRPC------- -KKILPDRMRAARDRDNRKLVDFIVREKGAD------------------- --------------------------------------------PHLLDI LQGRKQSRWLTMFLTPHRDLLCFETYLEDDDQLEVVTKHLQEI-YxKQMD KTMLTRIRDDKVNFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAIAATDGLDYKAAEEKYLRGPP----- ---------------------------------------VHYR----EKE LFDRNVLKKRR---RKP--------------------------------- -----------------------xTx------------------------ xxx-------------x--------------------------------- ----------------------------------------------- >ENSP00000498408 -------------------------------------------------- ----x--DS-EYVLCSWKGRLWPAKVLCTRGTSPKT--KPEKAISLEVQI LAVDEKIKVKSTDVKTPTKFEMEDIAASA---AAQTKLGAPLREKMGYRG TLRVALEILKERTNLGG-G------------------------------- ------RKPHELx------------------------------------- ----------------------------------------------STxx ------------xxxxxxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx----------xxxxxxxxx------- -----------------------------------------------xx- -------------------------------------------------- -------------------------------------------------- --------------------RSxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxxxxxxxxxxxxxxAIAPTPGALPGDRSGA PRAIAPTPGAxxxGRSRARRAIAPTxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxSWVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---xxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxVPxxxxxxExWSRVGIGIAPxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxTCPLCExxxxxxxxxxxxxxxxxxxxxxxxx----- ----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------x xxxxxxxxxxxxxxxxxxxxxxGVSKATAPAPGALCxxxSRARRSIAPTP CLLCGDRSWVGMGIAPTPGALLxxxx-----------xxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx x------------------------------------------------- ------------------------xxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxRTSII PSPxALHGDRSPAHLDIAxTPGALHGxxxxxxxxxxxxxxxxxxxxxxxx MxxxxxxxxxxxDRS----------------------------------- --------W----------------------------------------- ----KRKAIASxxxxxxGNRSDRSRKRKAIAxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---xxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxPGAxxxxxxxxHTTxAPTPG------------------ -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxGALHxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------x----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xTSPAP-PA--- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxx------------------------ ---------------------xxx-------------------------- ----x-xxxLAxxxxxxx-------------------------------- --xxx-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xLANRKRKRP---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKQDGQ--------------- -------------------------------------------------- -----------------------------------PPSLAFPQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PHPIERGTMVWFKFQDHPFWPAV-------------------------- ----------VKSVSNTDKTARVLLLEANLHHG-KRGIQVPLRRLKHLDC KEKEKLLKRAQKAYKQSVNWCFSLISHYREGLVRGSFRGSFLDYYAADIS YPIRRAIQEGDLQIDFPKVNYGDL-E--DWEEETSLGG-KRPC------- -KKILPDRMRASWDRDNQKLVDFIVRRKGAD------------------- --------------------------------------------PHLLDI LQGRKQSRWLTAFLKPHRDLHCIETYLEDDDQLEVVAKHLQEI-Y-KQID KARLTLIRDDKVNFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------MICTIAALDGLDYKAAEEKYLRGPP----- ---------------------------------------VHYR----EKE LFDRNILKKAR---REP--------------------------------- -----------------------xTx------------------------ xxx-------------x--------------------------------- ----------------------------------------------- >ENSLAFP00000025198 x------------------------------------------------- ----x--DG-EYVLCNWKGRLWPAKVLSRSGTSPKS--KREVARHLEVQI LSLDEKIKVKSKQIQMLTESQMEAMASSW---VARSKFRAPTGEERAHRK ALNVALEILEERARLGH-S------------------------------- ------SAFHKEx------------------------------------- ----------------------------------------------TNxx ------------xx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------PKxxxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxx------------xxxxx----------------------------- -------------------------------------------------- -----------xxxxxxxxxxxxxxx------------------------ ---------------------xxx-------------------------- ----x--xxRARSxxxxx-------------------------------- --xxE-xxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RLTNRKRKLQxxxxx-----------------------------xxxxxx xx-----------------x------------------------------ -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxx-----xxxxxxxxxx x------------------------------RQGQ--------------- -------------------------------------------------- -----------------------------------SRCVARPQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCPTERGMVVWFKFQDYPYWPAV-------------------------- ----------VVSVQSVEKTARVLLIEAYMSQE-RRGIRVPLRRLKPLDC EQKPKLMNRARKLYGQSVDWCCSLVAHYREAVGHRSFVGSFLEYFAADIS YPIRKAVQEGEVDSDFPRVNYNDL-E--ESEEEPHLGG-KGRY------- -KKLLPDRMKAARDRGNQKLLDFIVKRKGAE------------------- --------------------------------------------RHLLDI VDGRKQSTWLDSFLGSARRMACIETYLEDEDQLDVLVRYLQEI-Y-EQID QRMLTRIKNDKVNFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISALEGLDYKDAEAKYLNGPP----- ---------------------------------------VHYR----EKE LFDRKALVERR---RRL--------------------------------- -----------------------x-------------------------- -------------------------------------------------- ----------------------------------------------- >ENSCHIP00000003017 -------------------------------------------------- ----x--DA-EYVLCNWQDQLWPAKVLSRSEASSDS--KRKKVFFLEVQI LSLDEKIQMESTETKILTKSQVEAIASSL---ATQSEVGDPPGEETAYAR SLKMALDILNARTNLIQ-V------------------------------- ------SSSDEEx------------------------------------- ----------------------------------------------TTIx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxxx--------------------- -------------------------------------------------- -----------------xxxKCxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ ------------xxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xGFIVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxPATSxxxxx-------------------------------- --xxE-NxDDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------DPCSVA NQNQPTVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxGSNERNFQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------EFE--E-EFQ-- --A----------------------------------------------- -------SDKSARASxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFLFHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -QRSFETGMIVWFKYQKYPFWPSV-------------------------- ----------IKSIRRKERKASVIFVEANMNPE-KRGVRVPFRRLKKFDC KEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFFEYYAADIS YPVRKIIKQDTFRNLFPKLQNENT-G--RSMSVISQTK-KMSF------- -QKILPDRMKSARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------SHLLAI LNGTKGSRWLKSFLNAHRFTPCIETYFEDEDQLDEVVKYLQEV-Y-KQID EKMLTRIRDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYQAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDSKILFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSBMUP00000026600 -------------------------------------------------- ----x--DA-EYVLCNWQDQLWPAKVLSRSEASSNS--KRKKVFSLEVQI LSLDEKIQMESTETKILTKSQVEAIASSL---ATQSEVSDPPGEETAYAR SLKMALDILNERTNLIQ-V------------------------------- ------SSSDEEx------------------------------------- ----------------------------------------------TTIx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxxx--------------------- -------------------------------------------------- -----------------xxxKCxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ ------------xxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xGFIVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAASxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------DPCSVA SQNQPTVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxGSNERNLQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------EFE--E-EFQ-- --A----------------------------------------------- -------SDKSARISxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFLFNYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -QRSFETGMIVWFKYQKYPFWPSV-------------------------- ----------IKSIRRKERKASVVFVEANMNPE-KRGVRVPFRRLKKFDC KEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFFEYYAADIS YPVRKIIKQDTFRNLFPKLQNENT-G--GSMSVTSQTK-KMSF------- -QKLLPDRMKSARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------SHLLAI LNGTKGSRWLKSFLNAHRFTPCIETYFEDEDQLDEVVKYLQEV-Y-KQID EKMLTRIRNDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGYR------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxxx---xx--------------------------- -xx-------------------------------------------- >ENSBIXP00005012855 -------------------------------------------------- ----x--DA-EYVLCNWQDQLWPAKVLSRSEASSNS--KRKKVFSLEVQI LSLDEKIQMESTETKILTKSQVEAIASSL---ATQSEVSDPPGEETAYAR SLKMALDILNERTNLIQ-V------------------------------- ------SSSDEEx------------------------------------- ----------------------------------------------TTIx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxxx--------------------- -------------------------------------------------- -----------------xxxKCxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ ------------xxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xGFIVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAASxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------DPCSVA SQNQPTVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxGSNERNLQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------EFE--E-EFQ-- --A----------------------------------------------- -------SDKSARISxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFLFNYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -QRSFETGMIVWFKYQKYPFWPSV-------------------------- ----------IKSIRRKERKASVVFVEANMNPE-KRGVRVPFRRLKKFDC KEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFFEYYAADIS YPVRKIIKQDTFRNLFPKLQNENT-G--GSMSVTSQTK-KMSF------- -QKLLPDRMKSARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------SHLLAI LNGTKGSRWLKSFLNAHRFTPCIETYFEDEDQLDEVVKYLQEV-Y-KQID EKMLTRIRNDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDSKILFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSBTAP00000048597 -------------------------------------------------- ----x--DA-EYVLCNWQDQLWPAKVLSRSEASSNS--KRKKVFSLEVQI LSLDEKIQMESTETKILTKSQVEAIASSL---ATQSEVSDPPGEETAYAR SLKMALDILNERTNLIQ-V------------------------------- ------SSSDEEx------------------------------------- ----------------------------------------------TTIx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxxx--------------------- -------------------------------------------------- -----------------xxxKCxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ ------------xxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xGFIVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAASxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------DPCSVA SQNQPTVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxGSNERNLQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------EFE--E-EFQ-- --A----------------------------------------------- -------SDKSARISxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFLFNYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -QRSFETGMIVWFKYQKYPFWPSV-------------------------- ----------IKSIRRKERKASVVFVEANMNPE-KRGVRVPFRRLKKFDC KEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFFEYYAADIS YPVRKIIKQDTFRNLFPKLQNENT-G--GSMSVTSQTK-KMSF------- -QKLLPDRMKSARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------SHLLAI LNGTKGSRWLKSFLNAHRFTPCIETYFEDEDQLDEVVKYLQEV-Y-KQID EKMLTRIRNDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDSKILFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSBBBP00000028086 -------------------------------------------------- ----x--DA-EYVLCNWQDQLWPAKVLSRSEASSNS--KRKKVFSLEVQI LSLDEKIQMESTETKILTKSQVEAIASSL---ATQSEVSDPPGEETAYAR SLKMALDILNERTNLIQ-V------------------------------- ------SSSDEEx------------------------------------- ----------------------------------------------TTIx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxxx--------------------- -------------------------------------------------- -----------------xxxKCxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ ------------xxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xGFIVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAASxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------DPCSVA SQNQPTVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxGSNERNLQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------EFE--E-EFQ-- --A----------------------------------------------- -------SDKSARISxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFLFNYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -QRSFETGMIVWFKYQKYPFWPSV-------------------------- ----------IKSIRRKERKASVVFVEANMNPE-KRGVRVPFRRLKKFDC KEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFFEYYAADIS YPVRKIIKQDTFRNLFPKLQNENT-G--GSMSVTSQTK-KMSF------- -QKLLPDRMKSARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------SHLLAI LNGTKGSRWLKSFLNAHRFTPCIETYFEDEDQLDEVVKYLQEV-Y-KQID EKMLTRIRNDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDSKILFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSAMEP00000019688 -------------------------------------------------- ----x--DA-EYVLCNWKDRLWPAKVLSRSEMSSDS--KRKKTFSLEVQI LSLDEKINVESTETKILNKSQIEAIASSL---AAQSEVSDPPRRETAYER SLKVALDILNERTNLSQ-A------------------------------- ------SSSDEEx------------------------------------- ----------------------------------------------TTTx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxxx--------------------- -------------------------------------------------- ----------------xxxxKCxxxxx----------------------- -------------------------------------------------- ---------xxxxxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xTFIVP-KV--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAxxxxxxx-------------------------------- --xxx-xxxxxGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NxxxxT SQNxP-xESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xLMNNETNLQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELG--E-ELQ-- --A----------------------------------------------- -------SDKSAQLNxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFVFNYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPAV-------------------------- ----------VKSIRRKERKASVIFVEVSMNPE-KRGIRVPFRRLKKFDC KEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFLEYYAADIS YPLRKVIKQDTFRNLFPKLHNENS-G--EQMAVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------NHLLAI LKGTKGSRWLKSFLNANRFSPCIETYFEDEDQLDEVVKYLQEV-Y-KQID EKMLTLIRDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDAKILFEKR---RKP--------------------------------- -----------------------LTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSUAMP00000013072 -------------------------------------------------- ----x--DA-EYVLCNWKDQLWPAKVLSRSEMSSDS--KRKKTFSLEVQI LSLDEKINVESTETKILNKSQIETIASSL---AAQSEVSDPPRKETAYER SLKVALDILNERTNLSQ-A------------------------------- ------SNSDEEx------------------------------------- ----------------------------------------------TTTx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxxx--------------------- -------------------------------------------------- ----------------xxxxKCxxxxx----------------------- -------------------------------------------------- ---------xxxxxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xTFIVP-KV--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVSxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCSST SQNQP-xESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xLMNNETNLQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELG--E-ELQ-- --A----------------------------------------------- -------SDKSAQLNxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFVFNYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPAV-------------------------- ----------VKSIRRKERKASVLFVEVSMNPE-KRGIRVPFRRLKKFDC KEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFAGSFLEYYAADIS YPLRKVIKQDTFRNLFPKLHNENS-G--EQMVVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------NHLLAI LKGTKGSRWLKSFLNANRFSPCIETYFEDEDQLDEVVKYLQEV-Y-KQID EKMLTLIRDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDAKILFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSNVIP00000018254 -------------------------------------------------- ----x--DA-EYVLCNWKDQLWPAKVLSRSEMSSNS--KRKKTFSLEVQI LSLDEKIKVESTETKILNKSQIEALASSL---EAQSEVSSPPREETAYER SLKVALDILNEKTDLSQ-A------------------------------- ------SSSDEEx------------------------------------- ----------------------------------------------TSTx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxxx--------------------- -------------------------------------------------- -----------------xxxKCxxxxx----------------------- -------------------------------------------------- ---------xxxxxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xTFIVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVSxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCSST SQNQP-xESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xLSNNEGNLQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELG--E-ELQ-- --A----------------------------------------------- -------SDKSAQLNxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFVFNYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPAV-------------------------- ----------VKSIRRKERKASVLFVEASMNPE-KRGIRVPFRRLKKFDC KEKQALVDKAREEYSESIDWCISLICDYRVRLGCGSFAGSFLEYYAADIS YPLRKVIKQDTFRNLFPKLHNENS-A--EQMVVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------NHLLAI LKGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID EKMLTLIRDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDAKILFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSMPUP00000018742 -------------------------------------------------- ----x--DA-EYVLCNWKDQLWPAKVLSRSEMSSNS--KRKKTFSLEVQI LSLDEKIKVESTETKILNKSQIEALVSSL---EAQSEVSSPPREETAYER SLKAALDILNEKTDLSQ-A------------------------------- ------SSSDEEx------------------------------------- ----------------------------------------------TSTx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxxx--------------------- -------------------------------------------------- -----------------xxxKCxxxxx----------------------- -------------------------------------------------- ---------xxxxxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xTFIVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVSxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCSST SQNQP-xESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xLRNNEGNLQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELG--E-ELQ-- --A----------------------------------------------- -------SDKSAQLNxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFVFNYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPAV-------------------------- ----------VKSIRRKERKASVLFVEASMNPE-KRGIRVPFRRLKKFDC KEKQALVDKAREEYSESIDWCISLICDYRVRLGCGSFAGSFLEYYAADIS YPLRKVIKQDTFRNLFPKLHNENS-A--EQMVVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------NHLLAI LKGKKGSRWLKSFLNSNRFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID EKMLTLIRDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGCR----ERE LFDSKILFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSPPRP00000020305 -------------------------------------------------- ----x--DA-EYVLCNWKDQLWPAKVLSRYETSLNS--KRKKTFSLEVQI LSLDEKIKVESTETKILNKSQIEAIASSL---AAQSEVSTPPREETAYER SLKVALDILNERIYLSQ-A------------------------------- ------SSSYDKx------------------------------------- ----------------------------------------------TTTx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxx----------------------- -------------------------------------------------- -----------------xxxECxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xTLTVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxQAISxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCSDT SQNQP-xESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xLVNNERNPQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELG--E-DLQ-- --A----------------------------------------------- -------SDKSVNLNxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFVFNYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPAV-------------------------- ----------VKSIRRKERKASVLFVEANMNPE-KRGIRVPFRKLKKFDC KEKQALVDKAREEYSESIDWCISLICDYRVRLGCGSFAGSFLEYYAADIS YPIRKVIKQDTFRNLFPKLHNENP-V--EQMVVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------NHLLAI LKGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEV-Y-KQID ERMLTLIRDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDAKILFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSCAFP00020008536 -------------------------------------------------- ----x--EA-EYVLCNWKDQLWPAKVLSRSEISSNN--KRKKTFSLEVQI LSLDEKIKVESTEAKILSKSQIEALASSL---AAQSEGSDLPIEETAYER SLKVALDILNERTNVSQ-A------------------------------- ------SSSDEEx------------------------------------- ----------------------------------------------TTTx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxxx--------------------- -------------------------------------------------- ----------------xxxxKCxxxxx----------------------- -------------------------------------------------- ---------xxxxxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKLSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xTFTVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxMAVSxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCSDT SQNQP-xESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxVNNERSLQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELG--E-ELQ-- --A----------------------------------------------- -------SDKSAQVNxx-xxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFVFNYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPAV-------------------------- ----------VKSIRRKERKASVLFVEASMNPE-KRGIRVPFRRLKKFDC KEKQALVEKAREDYSESIDWCISLICDYRVRLGCGSFSGSFLEYYAADIS YPIRKVIKQDTFRNLFPKLQNENP-A--EQMVVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------NHLLAI LKGTKASRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID EKMLTLIRDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDAKILFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSVVUP00000013010 -------------------------------------------------- ----x--EA-EYVLCNWKDQLWPAKVLSRSEISSNS--KRKKTFSLEVQI LSLDEKIKVESTETKILSKSQIEALASSL---AAQSEGSDLPIEETAYER SLKVALDILNERTNVSQ-A------------------------------- ------SSSDEEx------------------------------------- ----------------------------------------------TTTx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxxx--------------------- -------------------------------------------------- ----------------xxxxKCxxxxx----------------------- -------------------------------------------------- ---------xxxxxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKLSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xTFTVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxMAVSxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCSDT SQNQP-xESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxVNNERSLQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELG--E-ELQ-- --A----------------------------------------------- -------SDKSAQVNxx-xxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFVFNYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPAV-------------------------- ----------VKSIRRKERKASVLFVEASMNPE-KRGIRVPFRRLKKFDC KEKQALVEKAREDYSESIDWCISLICDYRVRLGCGSFSGSFLEYYAADIS YPIRKVIKQNTFRNLFPKLQNENP-A--EQMVVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------NHLLAI LKGTKASRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID EKMLTLIRDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDAKILFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSSSCP00000070456 -------------------------------------------------- ----x--EA-EYVLCNWQDQLWPAKVLSRSEASSNS--KRKKTFSLEVQI LLLDEKIKVESTETKILNKSQVEAIVSSL---AAESEASDPPREETAYGR ALKAALDILNERTNLIQ-A------------------------------- ------SSSDEEx------------------------------------- ----------------------------------------------NPTx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxKCxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xYFTVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxPAISxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCSGT SQNQPTVESxxxxxx----------------------------------- ---------------xxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xLGNNERNLQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------DLG--E-ERQ-- --A----------------------------------------------- -------SDKSVHVSxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFLFHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPAV-------------------------- ----------VKSIRRKERKASVLFVEANMNPE-KRGIRVPFRRLKKFDC KEKQALVDQAREEYSESIDWCISLICDYRVRIGCGSFAGSFLEYYAADIS YPLRKVIKQDTFRNLFPKLQNENP-T--ESMVVTSQTK-KMSF------- -QKILPDRMKSARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------SHLLAI LKGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID EKMLTLIRDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDAKIIFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSTTRP00000011041 -------------------------------------------------- ----x--DA-KYVLCNWQGQLWPAKVLSRSAASSNS--KRKKTFSLEVQI LSLDKTIKVESTETKILSKSQVEAIAFSL---AAQSEVSDPPREETAYAR SLKMALDILNERTNLIQ-A------------------------------- ------SSSDEGx------------------------------------- ----------------------------------------------TTTx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxKCxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xSFTVP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxPAISxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCSDT SQNQPTVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xx-NNERNLQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELG--E-ELQ-- --A----------------------------------------------- -------SDKSVHLNxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFIFHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPAV-------------------------- ----------VKSIRRKERKASVLFVEANMNPE-KRGIRVPFRRLKKFDC KEKQALVDKAREDYSESIDWCISLICDYRVRIGCGSFVGSFLEYYAADIS YPLRKVIKQDTFRNLFPKLQNENP-V--ESMVVTSQTK-KMSF------- -QKILPDRMKSARDRANKNLVDFIVNTKGTE------------------- --------------------------------------------SHLLAI LKGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID EKMLTLIRDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDAKIIFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSECAP00000002101 -------------------------------------------------- ----x--DA-EYVLCNWKDQLWPAKVLSRSETSSNS--KRKKTFSLEVQI LSLDEKIQVESTETKILNKSKIEAIASSL---AAQSEVGAPPREETTYER SLKVALDVLNERTNLSE-A------------------------------- ------SSSDEEx------------------------------------- ----------------------------------------------TTTx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxKRxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xIFTVP-KE--- -------------------------------------------------- -------------------------------------------------- --------------------xxGxxx------------------------ ---------------------xxx-------------------------- ----x--xxIPTSxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCSDT SQNQPIVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xLVDNERNLQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELG--E-EPQ-- --A----------------------------------------------- -------SDKSVHLNxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFVFHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPAV-------------------------- ----------VKSIRRKEKKASVLFVEANMNPE-KRGIRVPFRRLKKFDC KEKQALVDKAREDYSESIDWCISLICDYRVRIGCGSFSGSFLEYYAADIS YPIRKVLKQDTFRNLFPKLHNEDS-V--ESMVVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNARGTE------------------- --------------------------------------------NHLLAI LKGTKGSRWLKAFLNANRFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID ERMLALIRDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDAKIISEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSEASP00005000843 -------------------------------------------------- ----x--DA-EYVLCNWKDQLWPAKVLSRSETSSNS--KRKKTFSLEVQI LSLDEKIQVESTETKILNKSQIEAIASSL---AAQSEVGAPPREETTYER SLKVALDVLNERTNLSE-A------------------------------- ------SSSDEEx------------------------------------- ----------------------------------------------TTTx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxKRxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xIFTVP-KE--- -------------------------------------------------- -------------------------------------------------- --------------------xxGxxx------------------------ ---------------------xxx-------------------------- ----x--xxIATSxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCSDT SQNQPIVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xLVDNERNLQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELG--E-EPQ-- --A----------------------------------------------- -------SDKSVHLNxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFVFHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPAV-------------------------- ----------VKSIRRKEKKASVLFVEANMNPE-KRGIRVPFRRLKKFDC KEKQALVDKAREDYSESIDWCISLICDYRVRIGCGSFSGSFLEYYAADIS YPIRKVLKQDTFRNLFPKLHNEDS-M--ESMVVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNARGTE------------------- --------------------------------------------NHLLAI LKGTKGSRWLKAFLNANRFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID ERMLALIRDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDAKIISEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSPSMP00000018080 -------------------------------------------------- ----x--DA-EYVLCNWKDQLWPAKVLSRSEISSNS--KRKKAYSLEVQI LSLDEKIKVESTETKILNKSQIEAIASSL---AVQSEVSAPPAEETAYGR ALKVALDILNEKTNLSE-S------------------------------- ------SISDEEx------------------------------------- ----------------------------------------------TSIx ------------Fx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxKYxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxx------------------------------ -------------------------------------------------- ---------xxxxxxxxxx---------------xxxxxTKSSxxxxxxx xxxxxxxxx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xILIVS-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVSxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCFDA SENQPSMESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxENNERNLQ---------------------------------------- ----------------------------------xPxFx----------- --------------------------------------EPG--E-EVQ-- --A----------------------------------------------- -------SDTSLPQDxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFLLHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPAV-------------------------- ----------VKSIRRKERKASVLFVEANMNPE-KKGIRVTFRRLKKFDC KEKQTLVDKAREEYSESIDWCISLICDYRVRIGCGSFSGSFLEYYAADIS YPLRKVIKKDTFRSMFPKLHNENT-G--ESMVVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------SHLLAI LKGKKGSRWLKSFLNANRFMPCIETYFEDEDQLDEVVKYLQEV-Y-KQID ERMLTRIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LYDSKIIFEKR---RRP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSMICP00000005645 -------------------------------------------------- ----x--DA-EYVLCNWKDQLWPAKVLSRSETSSNS--KRKKAFSLEVQI LSLDEKITVDSTETKILNKSQIEAIASSL---AVQSEVSAPPAEETAYGR SLKVALDILNERKNLSE-S------------------------------- ------SISDEEx------------------------------------- ----------------------------------------------TSIx ------------Fx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxKYxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxxx-------------- --------------------------------------xxx---xxxxxx xxxxxxxxx----------------------------------------- -------------xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xILITP-KV--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxITVSxxxxx-------------------------------- --xxE-NxDDPGE------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NSCFDA SENQPSVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxANNERNLQ---------------------------------------- ----------------------------------xVxFx----------- -------------------------------------------x-EVQ-- --A----------------------------------------------- -------SDKSLPLDxxxxxxx-------xxx------------------ ------------------------------DEDEE--------------- -------------------------------------------------- -----------------------------------LPRFILHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFDTGMIVWFKYQKYPFWPAV-------------------------- ----------VKSIRRKEKKASILFVEANMNPQ-KKGIRVTFRRLKKFDC KEKQTLVDKAREEYSESIDWCISLICDYRVRLGCGSFSGSFLEYYAADIS YPIRKVIKQDTFRNRFPRLQNEDI-G--ESMVVTSQAK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------NHLMAI LKGTKGSRWLKSFLNANRFMPCIETYFEDEDQLDEVVKYLQEV-Y-KQID ERMLTLIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDAKIIFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSMLUP00000007731 -------------------------------------------------- ----x--DA-EYVLCNWKDQLWPAKVLSRCETSSNS--KRKKTFSLEVQI LSVNEKIKVESKETKILNKSQIEAIASSL---AAQSEGSYPPREETAYAR SLKMALGILNKRTNLNQ-S------------------------------- ------SSSDEEx------------------------------------- ----------------------------------------------TTTx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxKCxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-x-----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xIFIVP-KS--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAISxxxxx-------------------------------- --xxE-NxEDPGE------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NSCLDT SQNQP-xESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxGNNERSGQ---------------------------------------- ----------------------------------xPxFx----------- --------------------------------------EHG--E-ELQ-- --A----------------------------------------------- -------SDKSVPLNxxxxxxx-------xxx------------------ ------------------------------EEDEV--------------- -------------------------------------------------- -----------------------------------LPPVVFHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEAGMIVWFKYKKYPFWPAI-------------------------- ----------VKSIRRKEKKASVIFVEANMNRE-KRGIRVLLRRLKKFDC KEKQALVDKAREDYSESIDWCISLICDYRVRLGCGSFTGSFLEYYAADIS YPIRKVIRQDTFRNLFPKLHNEDS-M--EPMAMTSQTK-RMSF------- -KKILPDRMKSARDRANRNLVDFIVNAKGAE------------------- --------------------------------------------NHLLSI LNGTKASRWLKSFLKAKRFTPCIETYFEDEDQLDEVVQYLQEI-Y-KKIN ERMLARIRDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYQEAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDSKILVEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSMMUP00000030703 -------------------------------------------------- ----x--ES-EYVLCHWKDQLWPAKVLSRSETSSNS--KRKMGFSLEVQI LSLDEKIKMDSTETEILNKSQIEAIAASL---GLQSEDSALPKEETAYGR SLKVALDILNERTNLSQ-A------------------------------- ------STSDEEx------------------------------------- ----------------------------------------------ITMx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxECxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSLxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xILTMP-KT--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVPxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCLDT SQNQPSVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxMNSERNFQ---------------------------------------- ----------------------------------xVxFx----------- --------------------------------------ELE--E-DGQ-- --A----------------------------------------------- -------SDKSLLPSxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFILHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRPFEAGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLFIEANMNSE-KKGIRVNFRRLKKFDC KEKQMLVNKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKEIKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGAE------------------- --------------------------------------------NHLLAI VNGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEV-Y-NQID KIMPTWIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPC----- ---------------------------------------LGYR----ERE LFDAKIIYEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSTGEP00000017495 -------------------------------------------------- ----x--ES-EYVLCHWKDQLWPAKVLSRSETSSNS--KRKMGFSLEVQI LSLDEKIKMDSTETEILNKSQIEAIAASL---GLQSEDSALPTEETAYGR SLKVALDILNERTNLSQ-A------------------------------- ------STSDEEx------------------------------------- ----------------------------------------------ITMx ------------Px---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxECxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSLxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xILTMP-KT--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVPxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCLDT SQNQPSVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxMNSERNFQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELE--E-DGQ-- --A----------------------------------------------- -------SDKSLLPSxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFILHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRPFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLFIEANMNSE-KKGIRVNFRRLKKFDC KEKQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKEIKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGAE------------------- --------------------------------------------NHLLAI VNGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEV-Y-NQID KIMPTWIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPC----- ---------------------------------------LGYR----ERE LFDAKIIYEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSCSAP00000017684 -------------------------------------------------- ----x--ES-EYVLCHWKDQLWPAKVLSRSETSSNS--KRKMGFSLEVQI LSLDEKIKMDSTETEILNKSQIEAIAASL---GLQSEDSALPTEETAYGR SLKVALDILNERTNLSQ-A------------------------------- ------STSDEEx------------------------------------- ----------------------------------------------ITMx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxECxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSLxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xILTMP-KT--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVPxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCLDT SQNQPAVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxMNSERNFR---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELE--E-DGQ-- --A----------------------------------------------- -------SDKSLLPSxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFILHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRPFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLFIEANMNSE-KKGVRVNFRRLKKFDC KEKQMLVEKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKEIKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGAE------------------- --------------------------------------------NHLLAI VNGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEV-Y-NQIE QIMPTWIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPC----- ---------------------------------------LGYR----ERE LFDAKIIYEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSPTEP00000002028 -------------------------------------------------- ----x--ES-EYVLCHWKDQLWPAKVLSRSETSSDS--KRKKGFSLEVQI LSLDEKIKMDSTETEILNKSQIEAIAASL---GLQSEDSAPPTEETAYGR SLKMALDILNERTNLIQ-A------------------------------- ------STSDEEx------------------------------------- ----------------------------------------------ITMx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxECxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSLxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xILTMP-KT--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVPxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCLDT SQNQPSVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxMNSERNFQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELE--E-DGQ-- --A----------------------------------------------- -------SDKSLLPSxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFILHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRPFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLFVEANMNSE-KKGIRVNFRRLKKFDC KEKQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYFAADIS YPVRKEIKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVKAKGAE------------------- --------------------------------------------NHLLAI VNGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEV-Y-NQID QIIPTWIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPC----- ---------------------------------------LGYR----ERE LFDAKIIYEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSRROP00000007853 -------------------------------------------------- ----x--ES-EYVLCHWKDQLWPAKVLSRSETSSNS--KRKKGFSLEVQI LSLDEKIKMDSTETEILNKSQIEAIAASL---GLQSEDSAPPTEETAYGR SLKVALDILNERTNLSQ-A------------------------------- ------STSDEEx------------------------------------- ----------------------------------------------ITMx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxECxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSLxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xILTMP-KT--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVPxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCLDT SQNQPSMESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxMNSERNFQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELE--E-DGQ-- --A----------------------------------------------- -------SDKSLLPSxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFILHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRPFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLFVEANMNSE-KKGIRVNFRRLKKFDC KEKQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKEIKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGAE------------------- --------------------------------------------NHLLAI VNGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEV-Y-NQID QIIPTWIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPC----- ---------------------------------------LGYR----ERE LFDAKIIYEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSRBIP00000014134 -------------------------------------------------- ----x--ES-EYVLCHWKDQLWPAKVLSRSETSSNS--KRKKGFSLEVQI LSLDEKIKMDSTETEILNKSQIEAIAASL---GLQSEDSAPPTEETAYGR SLKVALDILNERTNLSQ-A------------------------------- ------STSDEEx------------------------------------- ----------------------------------------------ITMx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxECxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSLxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xILTMP-KT--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVPxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCLDT SQNQPSMESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxMNSERNFQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELE--E-DGQ-- --A----------------------------------------------- -------SDKSLLPSxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFILHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRPFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLFVEANMNSE-KKGIRVNFRRLKKFDC KEKQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKEIKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGAE------------------- --------------------------------------------NHLLAI VNGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEV-Y-NQID QIIPTWIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPC----- ---------------------------------------LGYR----ERE LFDAKIIYEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSPPYP00000023059 -------------------------------------------------- ----x--ES-EYVLCNWKDQLWPAKVLSRSETSSNS--KRKKAFSLEVQI LSLDEKIKLDSTETKILNKSQIEAIAASL---GLQSEDSAPPTEETAYGR SLKVALGILNERINLSQ-A------------------------------- ------STSDEEx------------------------------------- ----------------------------------------------ITMx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxGCxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSLxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xILIMP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVPxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCLDT SQNQTSMESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxMSSERNFQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELE--E-EGQ-- --A----------------------------------------------- -------SDKSLLPSxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFILHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRPFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLFVEANMNSE-KKGIRVNFRRLKKFDC KEKQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKEIKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------NHLLAI VNGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEV-Y-NQID QIMPTWIKEDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPC----- ---------------------------------------LGYR----ERE LFDAKIIYEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSP00000338641 -------------------------------------------------- ----x--ES-EYVLCNWKDQLWPAKVLSRSETSSNS--KRKKAFSLEVQI LSLDEKIKLDSTETKILNKSQIEAIAASL---GLQSEDSAPPTEETAYGR SLKVALGILNERTNLSQ-A------------------------------- ------STSDEEx------------------------------------- ----------------------------------------------ITMx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxGCxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSLxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx--------------------------xxxxxx----------- -------------------------------------------------- --------------------------------------xMLIMP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVPxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCLDT SQNQPSMESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxMSSERNFQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELE--E-EGQ-- --A----------------------------------------------- -------SDKSLLPSxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFILHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -THPFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLFVEANMNSE-KKGIRVNFRRLKKFDC KEKQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKETKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------NHLLAI VNGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEV-C-NQID QIMPTWIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPC----- ---------------------------------------LGYR----ERE LFDAKIIYEKR---RKA--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSPTRP00000038089 -------------------------------------------------- ----x--ES-EYVLCNWKDQLWPAKVLSRSETSTNS--KRKKAFSLEVQI LSLDEKIKLDSTETKILNKSQIEAIAASL---GLQSEDSAPPTEETAYGR SLKVALGILNERTNLSQ-A------------------------------- ------STSDEEx------------------------------------- ----------------------------------------------ITMx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxGCxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSLxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx--------------------------xxxxxx----------- -------------------------------------------------- --------------------------------------xILIMP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLAVPxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCLDT SQNQPSMESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxMSSERNFQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------ELE--E-EGQ-- --A----------------------------------------------- -------SDKSLLPSxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFILHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRPFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLFVEANMNSE-KKGIRVNFRRLKKFDC KEKQMLVDKAREDYSESIDWCISLICDYRVRIGCGSFTGSLLEYYAADIS YPVRKETKQDTFRNKFPKLHNEDA-R--EPMAVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------NHLLAI INGTKGSRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEV-C-NQVD QIMPTWIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPC----- ---------------------------------------LGYR----ERE LFDAKIIYEKR---RKA--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSSTOP00000016689 -------------------------------------------------- ----x--EV-EYVLCNWKDQLWPAKVLSRSETSSDS--KRQKTISLEVQI LSLDEKIEVDITETKILEKSQVEAIASSL---VLQLEDNAPPQEETAYRR SLKVALDILNERKKMSQ-A------------------------------- ------SISHEEx------------------------------------- ----------------------------------------------TIVx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxESxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx-xxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxx-xxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xIVTMP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxTAVSxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NPCTDA TQDQPSVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxVNNERSFQ---------------------------------------- ----------------------------------xLxLx----------- --------------------------------------ELE--E-DIQ-- --A----------------------------------------------- -------SDKSPNLNxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFILNYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPAV-------------------------- ----------VKSIRRKERKASVLFVEANINPE-KKGIRVPFRRLKKFDC KEKQALVDKAREEYSESIDWCISLICDYRVRIGCGSFTGSFLEYYAADIS YPIRKAIKQDTFRNRFPKLQSDDT-V--EQMVVTSQTK-KMAF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------NHLLAI LKGTKASRWLKSFLNANRFTPCIETYFEDDDQLDEVVKYLQEI-Y-KQID ESMLTRIKHDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIFSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDAKIIFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSUPAP00010020686 -------------------------------------------------- ----x--EV-EYVLCNWKDQLWPAKVLSRSETSSDR--KRQKTISLEVQI LSLDEKIEVDITETKILEKSQVEAIASSL---VLQSEDNAPPQEETAYRR SLKVALDILNERKKMSQ-A------------------------------- ------SISHEEx------------------------------------- ----------------------------------------------TIVx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxESxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxx-xxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxx-xxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xIVTKP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxTAVSxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NPCTDA TQDQPSVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxVNNERSFQ---------------------------------------- ----------------------------------xLxLx----------- --------------------------------------ELE--E-DIQ-- --A----------------------------------------------- -------SDKSPNLNxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFILNYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPAV-------------------------- ----------VKSIRRKERKASVLFVEANINPE-KKGIRVPFRRLKKFDC KEKQALVDKAREEYSESIDWCISLICDYRVRIGCGSFTGSFLEYYAADIS YPIRKAIKQDTFRNRFPKLQSDDT-V--EQMVVTSQTK-KMAF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------NHLLAI LKGTKASRWLKSFLNANRFTPCIETYFEDDDQLDEVVKYLQEI-Y-KQID ESMLTRIKHDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIFSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDAKIIFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSOGAP00000018814 -------------------------------------------------- ----x--DA-EYVLCNWKDQLWPAKVLSRSETSSDS--KRKKSFSLEVQI LSLDEKIKVDSTETKILTKCQIEAITASL---GEQSEVSSPSTEEMTYRR SLQAALDILNESTNLSQ-A------------------------------- ------SISDDx-------------------------------------- ----------------------------------------------TSTx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------x-----xxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------MKSSxxxxxxx x-xxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xIHAVP-KV--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLDISxxxxx-------------------------------- --xxD-IxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPHLEA SQSQPAVEPxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxGNRERDLQ---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------EL---x-xVQ-- --A----------------------------------------------- -------SDKSLPQNxxxxxxx-------xxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------LPRFILNYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -SRSYETGMIVWFKYQKYPFWPSV-------------------------- ----------VKSIRRKEKKASVLFVEADMNPE-KKGVRVSFRRLKKFDC KEKQALVEKAREEYSESIDWCISLICDYRVRLGCGSFSGSFLEYYAADIS YPIRKVTKQDTFRNKFPKLHNKDA-G--EAMVVTSQTK-KMSF------- -RKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------SHLLAI LNGTKASRWLKSFLNANRFTPCIETYFEDEDQLDEVVKYLQEV-Y-KQID ERMLAVIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPA----- ---------------------------------------LGYR----ERE LFDSKILFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSDNOP00000016486 -------------------------------------------------- ----x--DF-RYVLCNWKDQLWPAKVLSRSETSANN--KRKKTFSLEVQI LSLDEKIQVESTEIKILNKSQIEDIVSSL---VTQSETSAIPREVSAYER SLKVALDILNERTILSQ-V------------------------------- ------SISDEVx------------------------------------- ----------------------------------------------TTTx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxxxxxxxxxx-------------- --------------------------------------xxxxx------- -------------xxxx--------------------------------- -------------------------------------------------- -------------------xxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------AKSSxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xMLTAP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxQxxx------------------------ ---------------------xxx-------------------------- ----x--xxLVISxxxxx-------------------------------- --xxE-NxEDPGE------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCLEA NQNQHSMESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xLLNNERNLQ---------------------------------------- ----------------------------------xPxVx----------- --------------------------------------EF---x-xxQ-- --I----------------------------------------------- -------SDKSVHLNxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFVFHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMMVWFKYKKYPFWPAV-------------------------- ----------VKSIRRKEKKASVLFVEPTMNPA-KKGIRVLFRRLKKFDC KEKQALVDKAREDYSESIDWCISLICDYRVRIGCGSFAGSFLEYYAADIS YPIRKAMKQDTLRDIFPKLYNEDS-V--EPTVVTSQTK-KMSL------- -QKILPDRMKAARDRANRNLVDFIVKAKGTE------------------- --------------------------------------------NHLMDI LKGRKGSRWLKSFLNANRFMPCIETYFEDEDQLDEVVKYLQEF-Y-TQID EGMLTLIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----T-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGCR----ERE LFDAKIIFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSOCUP00000007882 -------------------------------------------------- ----x--DA-EYVLCNWKDQLWPAKVLSSYETSPNS--KRKKTFSLEVQI LSLEEKIIVDSSETKLLNKSQIEAIASSL---AVQSEAGASPRDETAYGR ALKVALDILNERPNLSE-A------------------------------- ------SISGEEx------------------------------------- ----------------------------------------------TATx ------------Ax---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxKYxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxx-x---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKPLxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ ------------xxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xTLFTP-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLPDSxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NPCLEP SQNQPSVESxxxxxx----------------------------------- -------------xxxxxxxxxxxx-------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxx----- ------------------------------xxxxxx-------------- xxANRERNLE---------------------------------------- ----------------------------------xLxFx----------- --------------------------------------DL---x-xFQ-- --A----------------------------------------------- -------SDKSLHLNxxxxxxx-------xxx------------------ ------------------------------EEEEE--------------- -------------------------------------------------- -----------------------------------LPRFIFQYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -KRSFETGMIVWFKYQKYPYWPAV-------------------------- ----------VKSIRRKERKASVLFVEANMTPE-KKGVRVSFRRLKKFDC KEKQTLVDKAREDYSESIDWCISLICDYRVRIGCGSFAGSFFEYYAADIS YPVRKVVKQETFRNIFPKLHNEDA-V--EHMTVTSQTK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------DHLQSI LNGTKGSRWLKSFLNAKRFSPCIETYFEDDDQLDEVVKYLQGV-C-NQVD EKMMTLIKHDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYKAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDSKILFEKR---RKP--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSTBEP00000005356 -------------------------------------------------- ----x--DA-EYVLCNWKDQLWPARVLSKYEVSSNS--KRKNTFSLEVQI LTLDEKINVDSADTKILSRSEIEALASSL---AVQSEVSA-PSEETAYGR SLKAALDILNERTNMSQ-V------------------------------- ------SIPDEEx------------------------------------- ----------------------------------------------ITTx ------------Fx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -------------------------------------------------- ------------------xxKCxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-x-----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxx--------------------------x---------------- -------------------------------------------------- -------------------------------------------P-KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxDxxx------------------------ ---------------------xxx-------------------------- ----x--xxLVVSxxxxx-------------------------------- --xxE-NxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ --------------------------------------------NPCVDA GQGQPSVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxVSGDRSLL---------------------------------------- ----------------------------------xLxSx----------- --------------------------------------EHE--E-EAQ-- --A----------------------------------------------- -------SDRPSALNxxxxxxx-------xxx------------------ ------------------------------EEDEV--------------- -------------------------------------------------- -----------------------------------LPPLVFHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLFVEANMNPE-KKGIRVGFRRLKKFDC KEKQALVEKAREDYSESIDWCISLICDYRVRIGCGSFTGSFLEYYAADIS YPVRRAIKRDTFRNIFPKLNNEDT-M--EPMAVTSQAK-KISF------- -QKTLPDRMKAARDRANRNLVDFIVNTKGTE------------------- --------------------------------------------SHLMAI LNGTKGSRWLKSFLNAKRFAPCIETYFEDEDQLDEVVKYLQEV-C-KQID ERMLALIK-DKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYSISVVDGLDYKAAEVKYLKGPS----- ---------------------------------------LGYR----ERE LFDAKIISEKR---RRS--------------------------------- -----------------------xTx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSCPOP00000010914 -------------------------------------------------- ----x--NP-EYVLCNWKDQVWPAKVLSRSKTSSRG--KRKSTSSLEVQI LSLDETVKVKSTETKTLNKSEIEAIVSSL---AVQSEVSDVHREDTPYGR ALKEALHILDKRAILSQ-A------------------------------- ------SITDEGx------------------------------------- ----------------------------------------------TSIx ------------Tx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxx------------------------ --------------------------------------x----------- ---------------------Cxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx-------- -----------------------------------xxxxxx--------- -------------------------------------------------- --xxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxx--x------------ -----------xxx---------xxxxxxxxxxxxxxxxxxxxxxxxKDE K------------------------------------------------- -----C------------------------VQSSLSKDE----------- -------------------------------------------------- -------------------------------------------------- --Nxxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xILTAS-KG--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLPVSxxxxx-------------------------------- --xxE-TxEDPEx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NPRLDV SQGQSPVESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxVNSERYLQ---------------------------------------- ----------------------------------xLxIx----------- --------------------------------------EFE--E-DAL-- --A----------------------------------------------- -------SDKSLRLNxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFIFQYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFEAGMIVWFKYKKYPFWPAV-------------------------- ----------VKSIRRKEKKASVLFVEANMNPE-KKGIRVPLRSLKKFDC KEKQELVDKAREEYNESIDWCISLICDYRVRIGCGSFSGSFLEYYAADIS CPMRKAIQRDTFRNMFPKLPNEDT-V--EQMVVTSQSK-KRSF------- -QKILPDRMKAARDRANRNLVDYIVNAKGTD------------------- --------------------------------------------SHLVAI LKRRKESRWLKSFLHQSTIMPCIETYIEDEDQLDEIVRYLQVL-Y-DHID KKLQTLIRDDKINFILQVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------VICSISAVDGLDYETAEAKYLKGPS----- ---------------------------------------LGCR----ERE LFDAKILVGKR---RKR--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSHGLP00000027751 -------------------------------------------------- ----x--NA-EYVLCKWKDQIWPAKVLSRSETSSDG--KRKNTFSLEVQI LSLDETVKVESTETKVLNKSDIEAIISSL---PVQSEVSASPREEMPYGR ALKEALDILNKRTNLSQ-A------------------------------- ------SITDEEx------------------------------------- ----------------------------------------------TTIx ------------Px---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx------xxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------x------------------ ----------------xxxxxxxxxxxxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- ----------------------------------------LTAS-KV--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLPVSxxxxx-------------------------------- --xxE-TxEDPEx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NPFLDA NRNQLCMESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxVNNNRSLQ---------------------------------------- ----------------------------------xLxIx----------- --------------------------------------ESE--E-DIQ-- --A----------------------------------------------- -------SDKSSHVDxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFVFHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPSV-------------------------- ----------IKNIRRKEKKASVLFVEANMNPE-KKGIRVSFRRLKKFDC KEKQALVDKAREEYSESIDWCISLICDYRVRLGCGSFSGSFLEYYAADIS YPMRKVVKHDTFRNMFPKLQNEDS-V--EQMVVTSQxK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------SHLLAI LKGTKGSRWLKSFLHAKRFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID KRMLTLIKDDKINFILEVLLP-------E--------------------- -------------------------------------------------- -----T-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDSKIIFEKR---RKT--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSHGLP00100027619 -------------------------------------------------- ----x--NA-EYVLCKWKDQIWPAKVLSRSETSSDG--KRKNTFSLEVQI LSLDETVKVESTETKVLNKSDIEAIISSL---PVQSEVSASPREEMPYGR ALKEALDILNKRTNLSQ-A------------------------------- ------SITDEEx------------------------------------- ----------------------------------------------TTIx ------------Px---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx------xxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------x------------------ ----------------xxxxxxxxxxxxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- ----------------------------------------LTAS-KV--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLPVSxxxxx-------------------------------- --xxE-TxEDPEx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NPFLDA NRNQLCMESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxVNNNRSLQ---------------------------------------- ----------------------------------xLxIx----------- --------------------------------------ESE--E-DIQ-- --A----------------------------------------------- -------SDKSSHVDxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFVFHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPSV-------------------------- ----------IKNIRRKEKKASVLFVEANMNPE-KKGIRVSFRRLKKFDC KEKQALVDKAREEYSESIDWCISLICDYRVRLGCGSFSGSFLEYYAADIS YPMRKVVKHDTFRNMFPKLQNEDS-V--EQMVVTSQxK-KMSF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------SHLLAI LKGTKGSRWLKSFLHAKRFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID KRMLTLIKDDKINFILEVLLP-------E--------------------- -------------------------------------------------- -----T-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LFDSKIIFEKR---RKT--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSFDAP00000011158 -------------------------------------------------- ----x--NA-EYVLCNWKDQVWPAKVLSRSETSSDG--KRKNTLVLEVQI LSLDETIKVESTETKILNKSEIEAIISSI---QVQSEVNAPPREETPYER ALKEALDILNKRTDLTQ-A------------------------------- ------SIT-xxx------------------------------------- ----------------------------------------------xTIx ------------Px---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx------xxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxx-xx---xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------x------------------ ----------------xxxxxxxxxxxxxxxxx---xxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xNITAP-KV--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxLPVSxxxxx-------------------------------- --xxE-TxEDPEE------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NPCLDA NQNQPCMESxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxVNNDRSLH---------------------------------------- ----------------------------------xLxIx----------- --------------------------------------EFE--E-DIQ-- --A----------------------------------------------- -------SDKSLHIDxxxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFVFHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PRSFETGMIVWFKYQKYPFWPSV-------------------------- ----------IKNIRRKEKKASVLFVEANMNPE-KKGVRVPFRRLKKFDC KEKQALVDEAREEYSESIDWCISLICDYRVRLGCGSFSGSFLEYFAADIS YPMRKAFKHDTFRNMFPKLQNEDT-G--EQMVVTSQSK-KMSF------- -QKILPDRMKAARDRANRNLVDFIVNAKGAE------------------- --------------------------------------------SHLLAI LKGTKGSKWLKSFLHAKRFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID KRMLTLIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPA----- ---------------------------------------LGYR----ERE LFDSKIIFEKR---RKT--------------------------------- -----------------------xP------------------------- -------------------------------------------------- --x-------------------------------------------- >ENSCLAP00000025311 -------------------------------------------------- ----x--SA-EYVLCNWKGQAWPGKVLSRSATSSGG--KGKKTFSLEVQI LSLDETVKVRSTETKVLRKSEIEAIVSSL---TVQSEVSALPREETPYER ALKEALDILNKGTNLSR-A------------------------------- ------SMTDEEx------------------------------------- ----------------------------------------------ATVx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxx------------------------ --------------------------------------x----------- -----------------xxxNCxxxxx----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxxxxxx----------- --------------------------------------xxx--------- ----------------------------------------------xxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxx--x------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-----------------------------xxxx----------- -------------------------------------------------- --------------------------------------xILTAS-EV--- -------------------------------------------------- -------------------------------------------------- --------------------xxDxxx------------------------ ---------------------xxx-------------------------- ----x--xxLPVSxxxxx-------------------------------- --xxE-TxEDPEE------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NTCLDA SQNQPCVGSxxxxxx----------------------------------- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxx- xxVNNERSLQxxxxx---------------------------x------- -------------------xxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxx-------xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPRFVLQYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PQSFETGTMVWFKYQKNPFWPAV-------------------------- ----------IKSVRPKERKASVLFVEANMSPE-KKGIRVNFRRLKKYDC KEKQELVEKAREEYSESIDWCISLICDYRVRLGCGSFSGSFLEYYAADIS YPMRKIIQCDTFRYRFPKLNNEDT-M--EQMAVTSQTK-KMAF------- -QKILPDRMKAARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------SHLLAI LKGKKGSRWLKTFLQTNRCMPCIETYFEDEDQLDEVVKYLQEI-Y-KQID KRMLTLIKDDKINFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAQAKYLKGPS----- ---------------------------------------LGYR----ERE LFDSKILFEKR---RKH--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >ENSCGRP00001009884 -------------------------------------------------- ----x--DG-EYVLCNWKEQLWPAKVLCRSEISSSS--KRKMAFSLKVQI LSLDEKITVDSKDIKVLSKAEVETIVSLL---AVESEVRVPPREETAYER ALKMALEIIRERSTQSQ-E------------------------------- ------NMPNEEx------------------------------------- ----------------------------------------------TTVx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxx-------------------------- -------------------------------------------------- --------xxxxxx------------x----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx---xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxx--------------------xxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -----------------xxx------------------xxxxxxxxxxxx xxxxExNxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NPCFYG SQTQSSVESxxxxxx----------------------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xLxLx----------- --------------------------------------DLE--E-EAR-- --A----------------------------------------------- -------SGKLLSLNxxxxxxx-----xxxDx------------------ -----------------------------xDDDED--------------- -------------------------------------------------- -----------------------------------LPRFILCYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRAFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLFVEANMSPQ-KKGVRVSFRRLKKYDC KEKQDLVEKARENYRESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLHNEDT-G--EQMAVTSHxK-RISF------- -QKILPDRMKPARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------DHLLGI LKGTKKSKWLKSFLNAKSFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID QKMLTLIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IISSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGCR----ERE LYDSKILFEKR---RRS--------------------------------- -----------------------xAx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSCGRP00015025689 -------------------------------------------------- ----x--DG-EYVLCNWKEQLWPAKVLCRSEISSSS--KRKMAFSLKVQI LSLDEKITVDSKDIKVLSKAEVETIVSLL---AVESEVRVPPREETAYER ALKMALEIIRERSTQSQ-E------------------------------- ------NMPNEEx------------------------------------- ----------------------------------------------TTVx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxx-------------------------- -------------------------------------------------- --------xxxxxx------------x----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx---xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxx--------------------xxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -----------------xxx------------------xxxxxxxxxxxx xxxxExNxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NPCFYG SQTQSSVESxxxxxx----------------------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xLxLx----------- --------------------------------------DLE--E-EAR-- --A----------------------------------------------- -------SGKLLSLNxxxxxxx-----xxxDx------------------ -----------------------------xDDDED--------------- -------------------------------------------------- -----------------------------------LPRFILCYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRAFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLFVEANMSPQ-KKGVRVSFRRLKKYDC KEKQDLVEKARENYRESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLHNEDT-G--EQMAVTSHxK-RISF------- -QKILPDRMKPARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------DHLLGI LKGTKKSKWLKSFLNAKSFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID QKMLTLIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IISSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGCR----ERE LYDSKILFEKR---RRS--------------------------------- -----------------------xAx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSMAUP00000013562 -------------------------------------------------- ----x--DG-EYVLCNWKEQLWPAKVLYSSETLSNS--KRKKAFSLEVQI LSLDEKITVDSKDVRVLSKSEVQTIVSLL---AVESEVRVPPREETAYER SLKMALEILKGRTTQSQ-E------------------------------- ------SMPNEEx------------------------------------- ----------------------------------------------TTVx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxx-------------------------- -------------------------------------------------- --------xxxxxx------------x----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKASxxxxxxx xxxxxx-xx---xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxx--------------------xxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -----------------xxx------------------xxxxxxxxxxxx xxxxExDxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NPCFYG SQNQSSGESxxxxxx----------------------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxx----------- --------------------------------------DLE--E-EAR-- --A----------------------------------------------- -------SGKLLSLNxxxxxxx-----xxxNE------------------ ------------------------------DDDED--------------- -------------------------------------------------- -----------------------------------LPRFILCYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRAFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLMVEANMNPQ-KKGVRVSFRRLKKYDC KEKQALVEKAREEYRESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIINQDTFRNIFPKIHNEDT-G--EQMAVASHAK-RLSF------- -QKILPDRMKPARDRANKNLVDFIVNAKGAE------------------- --------------------------------------------NHLLGI LKGTKKSKWLKSFLNAKSFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID QKMLTLIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYAAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LYDSKIIFEKR---RRS--------------------------------- -----------------------xAx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSPEMP00000029286 -------------------------------------------------- ----x--DG-EYVLCNWKEQLWPAIVLYRSESSSNS--KRKKTFSLEVQI LSLDEKITVDSKDTKVLSKSEVEAIMSSL---AGQSEVRVPPREETAYER SLKMALEIVKERTHQIQ-E------------------------------- ------SMQDGEx------------------------------------- ----------------------------------------------TTTx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxx-------------------------- -------------------------------------------------- --------xxxxxx------------x----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx---xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxx--------------------xxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxx------------------------ ---------------------xxx-------------------------- ----x-xxxPAVSxxxxx-------------------------------- --xxExNxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NPCLYG SQNQSSVESxxxxxx----------------------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xLxLx----------- --------------------------------------DLE--E-EAR-- --A----------------------------------------------- -------SGKLLSLNxxxxxxx-----xxxDD------------------ ------------------------------DDDED--------------- -------------------------------------------------- -----------------------------------LPRFILCYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRAFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLFVEANMNPQ-KKGVRVSFRRLKKYDC KEKQALVEKAREEYSESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLHNEDT-G--EQMAVTSHAK-RISF------- -QKILPDRMKPARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------DHLLGI LKGTKKSKWLKSFLNAKSFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID QKMLTLIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LYDSKIIFEKR---RRS--------------------------------- -----------------------xAx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSRNOP00000043912 -------------------------------------------------- ----x--DG-EYVLCSWKDQLWPAKVLDRSESPSDS--KRKKTLSVEVEI LSLDEKITVESKDTKVLTKSAVEAIMSSL---TVQSEVSFTPTEETAYER SLKMALEIVEERTNQSH-E------------------------------- ------SMAEEQx------------------------------------- ----------------------------------------------MATx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxx-------------------------- -------------------------------------------------- --------xxxxxx------------x----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------MK-xxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxx--------------------xxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxx------------------------ ---------------------xxx-------------------------- ----x--xxPAVSxxxxx-------------------------------- --xxExNxEDPGE------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NPGSYG SQSQSTVESxxxxxx----------------------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxx----------- --------------------------------------DLE--E-EAR-- --A----------------------------------------------- -------SGKLLSLNxxxxxxx-----xxDDE------------------ ------------------------------DDDED--------------- -------------------------------------------------- -----------------------------------LPRFILRYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRAFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLLVEADMNPQ-KRGVRVSLRRLKKYDC KEKQALVEKAREEYKESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLYNEDA-G--EQLPVASHAK-RVSF------- -RKILPDRMKPARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------DHLLGI LKGTKKSKWLKSFLNAKSFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID QKMLTLIKDDKIKFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LYDSKILFEKR---RRS--------------------------------- -----------------------xPx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSMUSP00000108666 -------------------------------------------------- ----x--DG-KYVLCNWKDQLWPAKVLDRSESPSES--KRKNTSSLEVEI LSLDEKITVESTDTKVLSKSAVEAIMSSL---AVQSEVIIAPREETAYER SLKMALEMVKEGTNLSQ-E------------------------------- ------SMSEEQx------------------------------------- ----------------------------------------------TATx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxx-------------------------- -------------------------------------------------- --------xxxxxx------------x----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKATxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxx--------------------xxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxx------------------------ ---------------------xxx-------------------------- ----x-xxxxxxxxxxxx-------------------------------- --xxExNxEDPGE------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NLVSYA NQNQSSVESxxxxxx----------------------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xLxLx----------- --------------------------------------DLE--E-EAR-- --A----------------------------------------------- -------SGKLLSLNxxxxxxx-----xxDNE------------------ ------------------------------DDDED--------------- -------------------------------------------------- -----------------------------------LPRFILHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRAFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLLVEADMSPQ-KKGVRVSLRRLKKYDC KEKQALVEKAREEYRESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLYNENV-G--EQLPMASQAK-RVSF------- -QKILPDRMKPARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------DHLLGI LKGTKKSKWLKSFLNAKSFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID QKMLTLIKDDKIKFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGCR----ERE LYDSKILFEKR---RRS--------------------------------- -----------------------xPx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSMSIP00000014471 -------------------------------------------------- ----x--DG-KYVLCNWKDQLWPAKVLDRSESPSDS--KRKNTSSLEVEI LSLDEKITVESTDTKVLTKSAVEAIMSSL---AVQSEVNVAPREETAYER SLKMALEMVKEGTNHSQ-E------------------------------- ------SMSEEQx------------------------------------- ----------------------------------------------TATx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxx-------------------------- -------------------------------------------------- --------xxxxxx------------x----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKATxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxx--------------------xxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxx------------------------ ---------------------xxx-------------------------- ----x-xxxxxxxxxxxx-------------------------------- --xxExNxEDPGE------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NLVSYA NQNQSSVESxxxxxx----------------------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xLxLx----------- --------------------------------------DLE--E-EAR-- --A----------------------------------------------- -------SGKLLSLNxxxxxxx-----xxDNE------------------ ------------------------------DDDED--------------- -------------------------------------------------- -----------------------------------LPRFILHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRAFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLLVEADMSPQ-KKGVRVSLRRLKKYDC KEKQALVEKAREEYRESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLYNENV-G--EQLPMASQAK-RVSF------- -QKILPDRMKPARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------DHLLGI LKGTKKSKWLKSFLSAKSFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID QKMLTLIKDDKIKFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGCR----ERE LYDSKILFEKR---RRS--------------------------------- -----------------------xPx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >MGP_SPRETEiJ_P0096572 -------------------------------------------------- ----x--DG-KYVLCNWKDQLWPAKVLDRSESPSDS--KRKITSSLEVEI LSLDEKITVESTDTKVLTKSAVEAIMSSL---AVQSEVNVAPREETAYER SLKMALEMVKEGTNHNQ-E------------------------------- ------SMSEEQx------------------------------------- ----------------------------------------------TATx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxx-------------------------- -------------------------------------------------- --------xxxxxx------------x----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKATxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxx--------------------xxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxx------------------------ ---------------------xxx-------------------------- ----x-xxxxxxxxxxxx-------------------------------- --xxExNxEDPGE------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NLVSYA NQNQSSVESxxxxxx----------------------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xLxLx----------- --------------------------------------DLE--E-EAR-- --A----------------------------------------------- -------SGKLLSLNxxxxxxx-----xxDNE------------------ ------------------------------DDDED--------------- -------------------------------------------------- -----------------------------------LPRFILHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRAFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLLVEADMSPQ-KKGVRVSLRRLKKYDC KEKQALVEKAREEYRESIDWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLYNENV-G--EQLPMASQAK-RVSF------- -QKILPDRMKPARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------DHLLGI LKGTKKSKWLKSFLNAKSFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID QKMLTLIKDDKIKFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGCR----ERE LYDSKILFEKR---RRS--------------------------------- -----------------------xPx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >MGP_CAROLIEiJ_P0092809 -------------------------------------------------- ----x--DG-EYVLCNWKDQLWPAKVLDRSESPSDS--KRKNSSSLEVEI LSLDEKITVESTDAKVLTKSAVEAIMSSL---AVQSEVNVAPREETAYER SLKMALEIVKEGTNHSQ-E------------------------------- ------SMSEEQx------------------------------------- ----------------------------------------------TATx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxx-------------------------- -------------------------------------------------- --------xxxxxx------------x----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKASxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxx--------------------xxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxx------------------------ ---------------------xxx-------------------------- ----x-xxxxxxxxxxxx-------------------------------- --xxExNxEDPGE------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NLVSYA NQNQSSVESxxxxxx----------------------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xLxLx----------- --------------------------------------DLE--E-EAR-- --A----------------------------------------------- -------SGKLLSLNxxxxxxx-----xxDNE------------------ ------------------------------DDDED--------------- -------------------------------------------------- -----------------------------------LPRFILHYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRAFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLLVEADMSPQ-KKGVRVSLRRLKKYDC KEKQALVEKAREEYRESIDWCISLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLYNENV-G--EQLPMASQAK-RVSF------- -QKILPDRMKPARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------DHLLGI LKGTKKSKWLKSFLNAKSFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID QKMLTLIKDDKIKFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGCR----ERE LYDSKILFEKR---RRS--------------------------------- -----------------------xPx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >MGP_PahariEiJ_P0090419 -------------------------------------------------- ----x--DG-EYVLCNWKGQLWPAKVLDKSESPSDS--KRKNTPSLKVEI LSLDEKITMESTDTKVLTKSAVEAIMSSL---AVQSEVNLAPREETTYER SLKMALEIVKGRTNQSQ-E------------------------------- ------STSEEQx------------------------------------- ----------------------------------------------TATx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxx-------------------------- -------------------------------------------------- --------xxxxxx------------x----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKASxxxxxxx xxxxxx-xx----xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxx--------------------xxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxx------------------------ ---------------------xxx-------------------------- ----x-xxxxxxxxxxxx-------------------------------- --xxExNxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NPSSYA NQNQSSVEPxxxxxx----------------------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxx----------- --------------------------------------DLE--E-EAR-- --A----------------------------------------------- -------SGKLLSLNxxxxxxx-----xxDDE------------------ ------------------------------DDDED--------------- -------------------------------------------------- -----------------------------------LPRFILRYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRAFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLLVEADMSPQ-KKGVRVSLRRLKKYDC KEKQALVEKAREEYRESINWCVSLICDYRVRLGCGSFTGSFFEYYAADIS YPVRKIIKQDTFRNIFPKLYNENT-G--EHLPVASHAK-RVSF------- -QKILPDRMKPARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------DHLLGI LKGTKKSKWLKSFLNAKSFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID QKMLTRIKDDKIKFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGCR----ERE LYDSKILFEKR---RRS--------------------------------- -----------------------xPx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSMUGP00000028818 -------------------------------------------------- ----x--DN-EYVLCNWKDQLWPAKVLYRCTTPLGS--KKKKTFSLGVQI LALDEKITVDSKDTRALSECEVKAIVSSL---AVQSEVKVPPREETVYER SLKMALEIVKERTNQSQ-E------------------------------- ------xISDEAx------------------------------------- ----------------------------------------------TSTx ------------Ax---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxx-------------------------- -------------------------------------------------- --------xxxxxx------------x----------------------- -------------------------------------------------- ---------xxxx-xxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx---xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxx--------------------xxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxx------------------------ ---------------------xxx-------------------------- ----x--xxPAVSxxxxx-------------------------------- --xxExNxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NPCFYA SQSQSSVESxxxxxx----------------------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xLxLx----------- --------------------------------------DLE--E-EAR-- --D----------------------------------------------- -------SGKLLSLHxxxxxxx-----xxxx------------------- ------------------------------DEDED--------------- -------------------------------------------------- -----------------------------------LPRFILCYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRAFETGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLLVEANMNPQ-KKGVRVSLRRLKKYDC KEKQELVEKAREEYRESIDWCVSLICDYRVRLGCRSFTGSFFEYYAADIS YPVRKLIKQDTFRNIFPKLYNEDT-R--GQLPVTSHxK-RMSF------- -QKILPDRMKPARDRANKNLVDFIVNAKGTE------------------- --------------------------------------------DHLLSI LKGTKKSKWLKAFLHAKSFTPCIETYFEDEEQLDEIVKYLQEI-Y-KKID QKMLTLIKDDKIKFILEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISAVDGLDYEAAEAKYLKGPS----- ---------------------------------------LGYR----ERE LYDSKIISGKR---RQS--------------------------------- -----------------------xRx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSNGAP00000008556 -------------------------------------------------- ----x--DA-EYVLCNWKDQLWPAKVLSRSETSSNT--KKKMTFSLEVQI LSLDEKITVDSTEAKVLSKSEIETIMSSL---AVQSEVRALPREETAYER SLKAALEILKERTTLSE-E------------------------------- ------xMSDEEx------------------------------------- ----------------------------------------------TTAx ------------Sx---xxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- -------------------------------------------------- -------------------xxxxxxxxx---------------------- -----------------------------------------xxxxxxxxx xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- ---------------------------------------TKSSxxxxxxx xxxxxx-xx---xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxx--------------------xxxxxx---------------- -------------------------------------------------- ---------------------------------------------KA--- -------------------------------------------------- -------------------------------------------------- --------------------xxExxx------------------------ ---------------------xxx-------------------------- ----x--xxPAMSxxxxx-------------------------------- --xxExNxEDPGx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxx---------------- --------------------------------------------NPCTYA SQNQSSVESxxxxxx----------------------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xLxLx----------- --------------------------------------DLD--E-EAR-- --A----------------------------------------------- -------SGKLLELNxxxxxxx-----xxDEN------------------ ------------------------------EDDEE--------------- -------------------------------------------------- -----------------------------------LPRFILCYE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TRAFEEGMIVWFKYQKYPFWPAV-------------------------- ----------IKSIRRKERKASVLFVEANMNPQ-KKGVRVSFRQLKKYDC KEKQALVEKAREEYRDSIDWCISLICDYRVRLGCGSFSGTFFEYYAADIS YPVRKIIKQDTFRNIFPKLYDEDT-M--EPMTVASHTK-RMTF------- -QKILPDRMKPARDRANRNLVNFIVNAKGTE------------------- --------------------------------------------DHLLGI LKGTKKSKWLKSFLNAKSFTPCIETYFEDEDQLDEVVKYLQEI-Y-KQID PKMLIQIKNDKIKFIMEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSISFVDGLDYETAEAKYLKGPS----- ---------------------------------------LGYR----ERE LYDSKIIFEKR---RRS--------------------------------- -----------------------xAx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSOCUP00000009209 -------------------------------------------------- ----x--VA-KYILCDWRGHLWPAKVLSRRGPSAKA--KRKRALLLAVQI LGVDEKIRVKRADVKALTTSDLEAVAFSA---RxxPxGSMPLGQKRGYRR ALRAAWEMLRKRESWGQ-E------------------------------- ------x------------------------------------------- ---------------------------------------xx--------- -----------------xxxxxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx-------------------------- ----------xxxxxxxxxx------------------------------ -----------------xxxxxxxxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxx--------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxxxxxxxxxxxTEAPxxxxxxx xxxxxx-------------------------------------------- -------------------------------------xx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxx--------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- ---------------------xxxx------xxxxxxx------------ -----------xxxxxx---------xxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxx-------------xxxx--------------------- -------------------------------------------------- -------------------------------------------x-xx--- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxx------------------------ ---------------------xxx-------------------------- ----x--xxxxxxxxxxx-------------------------------- --xxx-xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------- -------xxxxxxxxxxxxDKGxxxxxxxxxxx----xx----------- ------------xxxxTG--LLTP---------GEKRSNKKQRLVD---- -----KGPAKVPR------KSGRK--ExEGPx------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxxxxxRRLD DRTRPEIRxxYKKGEEEPx------------------------------- ------------xxxxxxxxxxxxxxxxxxxxxxxxxxGKAGRNEEDELA SMFMALHMSPPTETQQLVNKPLxxxxxxGGxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxPxxxxxxx------------xxEEGP-------------- ----------------------HAxxxx---xxx---------------- --------------xxxxxxxxxxxxxxxxxxEKSDRxxxxxxxxxxxxx xxxxxxxxxRLIDKEPPSIHCKxxxxxxxxxxx----xxxxx-------- --------------------xxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxx-------xxxxxxxxxxxxY-------- ------------------------------RExxxxxxxxxxxxxxxCPT xxxxxxxxxxxxxxxxxxKxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xPSPIGKGALVWFKFQEHPYWPAV-------------------------- ----------VKSVSETDKTARVFLIEASLCPE-KRGIRVPLARLKHLDC AGKDKFLKTARKAYPEGVNWVFSLITHYRKQLGRGSFVGSFLNYYTADVS YRIRRVIQDSELDITFPKVDYTEL-ExxEDSEETALQG-MPSH------- -KKILPDRTKAAWDRDNQKLVDFIVKKKGAD------------------- --------------------------------------------SHLLAI LKGKKQSRWLRSFLNSHQYVVCVETYLEDEDQLELVTKHLQQV-Y-EHID QRLQALVR-DKVKFVLEVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICSIAALDGLEYKDAEKKYLQGPP----- ---------------------------------------VHYR----EKE LFDKNSLKRVR---RRL--------------------------------- -----------------------xSx------------------------ xxx-------------xxxxxxxx-xxxxxx------------------x xxx-------------------------------------------- >ENSSCAP00000008420 -------------------------------------------------- ----Mx-DQ-EFILCKWKRRLWPAKVLCKPGVAGSSxxATPKRMGFKAEI LGLEKQVSVSSANVVPLTEERIKAIASTL----EQKKTMSEAVEELQYRC SLKIALDILQETDSSSQ-Mx------------------------------ -------PA-xxxxxxx--------------------------------- -------------------------------------------------- ------------Sx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx---------------------xx--- -----xxxxxxxx------------xxxxxxxxx---------------- -------------------xxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxxx--------- ---------xxxx------------------------------------- -------------------------------------------------- xxxx-xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxxxxxxxxxxxxxx--xxxxxxxxxxxx------xxxxxx-xxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xx-x--------xxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-------------------------------------------- --------------------------------------------xxxxxx xxxxxxxxxxxxxxxx---------------------------------- -------------------------------------------------- -----------------------------------x-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxxxxxxxxx----------- --xxx-----------------------------------------xxxx xxxx---------------------------------xxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx x-------------------------------------xxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- ------------------------------xxxxxx-------------- x-------xxxxxx--x--------------xxx---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- xxxNKx-------------------------------------------- -----------------------------------xxxx----------- -------------------------------------------x-x-x-x xxPxxxxxxxxxxxxxxxxx------------------------------ -------------------xxx-----x---------------------- ------------------------------EEEEN--------------- -------------------------------------------------- -----------------------------------FPSVLSHRE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PKFFEEGMLVWCKLRRYPYWPAV-------------------------- ----------VKAVKRKHRRACVLFIDGTTNEK-KKGFSVSLKSLKHLDC EEKQELIERAKENYSREIEWCLQLIQDYRIRVGCRSFTGSFLEYFAADIS YPVRKQGYQSVVQMAFPNTGEEGA-G--ESSSDTSP---xxPP------- -RKLLPDRTRAARDRENKKLVEFIVKTKGAE------------------- --------------------------------------------EHLLGI LKSGKQSRWLKKFLNSSRYITCVETYLEDEEQLDLVVGYLKEV-Y-REMD TKNLHQILGDGIRFISDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAIAAVDDIDYEKAEEKYIKGPP----- ---------------------------------------VSKR----ERE LFDEQVLGSKK---LKT--------------------------------- ---------------------xxxxx------------------------ -xx----------------------------------------------- ----------------------------------------------- >ENSJHYP00000003344 -------------------------------------------------- ----Mx-DQ-EFVLCKWKRRLWPAKVLCKPGVAGSSxxATTKKMGFKAEI LGLEKQVSVSSANVVPLTEERIKAIASTL----EQKKTMSEAVEELQYRC SLKIALDILHETDSSTQ-Mx------------------------------ -------LA-xxxxxxx--------------------------------- -------------------------------------------------- ------------Sx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx---------------------xx--- -----xxxxxxxx------------xxxxxxxxx---------------- -------------------xxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxxx--------- ---------xxxx------------------------------------- -------------------------------------------------- xxxx-xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxxxxxxxxxxxxxx--xxxxxxxxxxxx------xxxxxx-xxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxx--------xxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-------------------------------------------- --------------------------------------------xxxxxx xxxxxxxxxxxxxxxx---------------------------------- -------------------------------------------------- -----------------------------------x-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxxxxxxxxx----------- --xxx-----------------------------------------xxxx xxxx---------------------------------xxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx x-------------------------------------------xxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- ------------------------------xxxxxx-------------- x-------xxxxxx--x--------------xxx---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- xxxNKx-------------------------------------------- -----------------------------------xxxx----------- -------------------------------------------x-x-x-x xxAxxxxxxxxxxxxxxxxx------------------------------ -------------------xxx-----x---------------------- ------------------------------EEEEN--------------- -------------------------------------------------- -----------------------------------LPSVLSYRE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PKFFEEGMLVWCKLRRYPYWPAV-------------------------- ----------VKAVKRKHRRACVLFIDGTTNEK-KKGFSVSLKSLKHFDC EEKQELIERAKENYCREIKWCLHLIQDYRIRVGCRSFTGSFLEYFAADIS YPVRKEGYQSVVQMAFPNTGEEGA-G--ESSSDTSP---xxPP------- -RRLLPDRTRAARDRENKKLVEFIVKSKGAE------------------- --------------------------------------------EHLLGI LKSGKQSRWLKKFLNSRRYVTCVETYLEDEEQLDLVVGYLKEV-Y-REMD TKNLRQILGDGITFISNVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAIAAVDDIDYEKAEEKYIKGPP----- ---------------------------------------VSKR----EKE LFDEQVLGSKK---LKT--------------------------------- ---------------------xxxxx------------------------ -xx----------------------------------------------- ----------------------------------------------- >ENSCCEP00000001778 -------------------------------------------------- ----Mx-DQ-ELVLCKWKRRLWPAKVLCKPGVAGSSxxATTKRMGFKAEI FGLEKQVSVSSANVVPLTEERIKAIASTL----EQKNSMSEAVEELQYRC SLKIALDILHQTDSGSQ-Ix------------------------------ -------PA-xxxxxxx--------------------------------- -------------------------------------------------- ------------Sx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx---------------------xx--- -----xxxxxxxx------------xxxxxxxxx---------------- -------------------xxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxxx--------- ---------xxxx------------------------------------- -------------------------------------------------- xxxx-xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxx-----xxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxxxxxxxx--------- -------------------------------------------------- --xxxxxx-xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxxxxxxxxxxxxxx--xxxxxxxxxxxx------xxxxxx-xxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxx--------xxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-------------------------------------------- --------------------------------------------xxxxxx xxxxxxxxxxxxxxxx---------------------------------- -------------------------------------------------- -----------------------------------x-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxxxxxxxxx----------- --xxx-----------------------------------------xxxx xxxx---------------------------------xxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx x-------------------------------------xxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- ------------------------------xxxxxx-------------- x-------xxxxxxx-x--------------xxx---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- xxxNKx-------------------------------------------- -----------------------------------xxxx----------- -------------------------------------------x-x-x-x xxPxxxxxxxxxxxxxxxxx------------------------------ -------------------xxx-----x---------------------- ------------------------------EEEEN--------------- -------------------------------------------------- -----------------------------------FPSVLSHRE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PKFFQEGMLVWCKLQRYPYWPAV-------------------------- ----------VKAVKRKHRRACVLFIDGTTNEK-KKGFSVSLKSLKHFDC EEKQELIERAKENYSREIEWCLQLILDYRIRVGCHSFTGSFLEYFAADIS YPVRKEGYQSVVQMAFPNTEGEGA-G--ESSSDTSP---xxPP------- -RKLLPDRTRAARDRENKKLVEFIVKSKGAE------------------- --------------------------------------------EHLLGI LKSGKQSRWLKKFLNSSRYMTCVETYLEDEEQLDLVVGYLKEV-Y-REMD TKNLHQILGDGIRFISDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAIAAVDDIDYEKAEEKYIKGPP----- ---------------------------------------VSKR----ERE LFDEQVLGSKK---LKT--------------------------------- ---------------------xxxxx------------------------ -xx----------------------------------------------- ----------------------------------------------- >ENSPMJP00000015387 -------------------------------------------------- ----Mx-DQ-EFVLCKWKRRLWPAKVLCKPGVTGGSxxATTKRMGFKAEI LGLEKQVSVSSANVVPLTEERIKAIASTL----EQKKSMSEAVEELQYRC SLKIALDILHQTDSGSQ-Tx------------------------------ -------PA-xxxxxxx--------------------------------- -------------------------------------------------- ------------Sx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxx---------------------xx--- -----xxxxxxxx------------xxxxxxxxx---------------- -------------------xxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxxx--------- ---------xxxx------------------------------------- -------------------------------------------------- xxxx-xxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxx-----xxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxxxxxxxx--------- -------------------------------------------------- --xxxxxx-xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxxxxxxxxxxxxxx--xxxxxxxxxxxx------xxxxxx-xxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxx--------xxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-------------------------------------------- --------------------------------------------xxxxxx xxxxxxxxxxxxxxxx---------------------------------- -------------------------------------------------- -----------------------------------x-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxxxxxxxxx----------- --xxx-----------------------------------------xxxx xxxx---------------------------------xxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx x-------------------------------------xxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- ------------------------------xxxxxx-------------- x-------xxxxxxxxx--------------xxx---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- xxxNKx-------------------------------------------- -----------------------------------xxxx----------- -------------------------------------------x-x-x-x xxSxxxxxxxxxxxxxxxxx------------------------------ -------------------xxx-----x---------------------- ------------------------------EEEEN--------------- -------------------------------------------------- -----------------------------------FPSVLSHRE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PKFFEEGMLVWCKLQRYPYWPAV-------------------------- ----------VKAVKRKHRRACVLFIDGTTNEK-KKGFSVSLKSLKHFDC EEKQELIERAKENYSREIEWCLQLILDYRIRVGCHSFTGSFLEYFAADIS YPVRKEGYQSVVQMAFPNTEGEGA-G--ESSSDTSP---xxPP------- -RKLLPDRTRAARDRENKKLVEFIVKSKGAE------------------- --------------------------------------------EHLLGI LKSGKQSRWLKKFLNSSRYMTCVETYLEDEEQLDLVVGYLKEV-Y-REMD TKNLHQILGDGIRFISDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IICAIAAVDDIDYEKAEEKYIKGPP----- ---------------------------------------VSKR----ERE LFDEQVLGSKK---LKT--------------------------------- ---------------------xxxxx------------------------ -xx----------------------------------------------- ----------------------------------------------- >ENSMVIP00005021933 -------------------------------------------------- ----Mx-DP-EFVLCKWKRRLWPAKVLCKAGVAGSTxxGTTAKMGFKAEI LGLEKQVSVSSADAVPLTEERIKAIASSL----EQKNNVSEAVEELQYRC SLKIALDILTQTGSGRQ-Ax------------------------------ -------PA-xxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx- xxxxxxxx-xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxxxxxxxxxxxxxx--xxxxxxxxxxxx------xxxxxx-xxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxx--------xxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxx-------------------------------------------- --------------------------------------------xxxxxx xxxxxxxxxxxxxxxx---------------------------------- -------------------------------------------------- -----------------------------------x-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxxxxxxxxx----------- --xxx-----------------------------------------xxxx xxxx---------------------------------xxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx x-------------------------------------xxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- ------------------------------xxxxxx-------------- x-------xxxxxx--x--------------xxx---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- xAGNKAKQLQ---------------------------------------- ----------------------------------LPxSx----------- -------------------------------------------x-x-x-x xxPxxxxxxxxxxxxxxxxx------------------------------ -------------------xxx-----x---------------------- ------------------------------EEEED--------------- -------------------------------------------------- -----------------------------------FPCVLSCQV------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PQSIEEGMLVWCKFRRYPYWPAV-------------------------- ----------VKTVKRKPRRACVLFIDGTTNEK-KKGFSVSLKTLKHFDC EEKQELIDRAKENYPQEIEWCLQLIRDYWVRVGCHSFTGSFLEYLAADIS YPVRKQGHQGEVEMTFPSTAEEDL-G--ESSLENSP---xxPL------- -RRLLPDRSRAARDRENKKLVEFIVKTKGAE------------------- --------------------------------------------EHLRGI LKSGKKSRWLKKFLNSYWYVTRVETYLEDEEQLELVFDYLKEV-Y-REMD TTNLRQILGDGIKFISDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYAIAAVYDIDYKKAEEKYIKGPP----- ---------------------------------------VTKR----ERE LFDEQIRAWKK---LKS--------------------------------- ---------------------xxxxx------------------------ -xx----------------------------------------------- ----------------------------------------------- >ENSGALP00000015790 -------------------------------------------------- ----Mx-KR-GYILCGWRERLWPAKVL--xxxxxxxxxTGAQEETLEVEI IGLKERVSVKQEDAVPLEEACIEDIVSNL----NEKADPNEAVEELKYRC ALKTALDYLKEDVSARE-Ax------------------------------ -------PSKEGxxxxx--------------------------------- -------------------------------------------------- ------------Sx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxx------------------------ ------xxxxxx-------------------------------------- -------------------------------------------------- ---------xxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------xxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------xxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxx--xxxxxxxxxxxxxxxxxxxxxxxx-xxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxx---------xx--- -------------------------------------------------- --xxxxxxxxx--------xxxxxxxxxxxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxx-xxxxxx----------- --xxx-----------------------------------------xxxx xxxx---------------------------------xxxxxxxxxxxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxx------xxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- ------------------------------xxxxxx-------------- xxxxxxxxxxxxxx--x--------------xxx---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- xVVNKAKEFH---------------------------------------- ----------------------------------LPDFx----------- -------------------------------------------x-x-x-x xxPxxxxxxxxxxxxxxxxx------------------------------ -------------------xxx-------xxx------------------ ------------------------------DDEEE--------------- -------------------------------------------------- -----------------------------------LPSILSHQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PESIDKGILVWCKWQRYPYWPAV-------------------------- ----------VKNVKRKHRKANVLFIEGDTSDK-KKSFSVSLRNLKHFDC EEKQDLIDQAKKDYCQEIEWCIQLISDYRIRVGCHSFTGSFLEYFADDIS YPVRKQYQQSSVQMTFPSVAEEDL-E--DSLLETSP---xxPS------- -RKLLPDRTRAARDKANKKIVEFIVKTKGAE------------------- --------------------------------------------EHLLAI LKCRKESRWMKDFLSSRQYGTCIETYLEDEEQLELVVNYLKEVxY-HEID TAHLHRLRGDGVKFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYAISAVDDIDYKKAEEKYMKGPS----- ---------------------------------------VSKR----ERE EFDEEILERKR---LQA--------------------------------- ---------------------xxxxx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSNMEP00000002659 xxxxxxxxxxxxxxxxxxxxKxxxxxxxxNKVLFQDYLYLESVxxxSFPT RGAxMx-NR-GYVLCSWRERLWPAKVLLKPGLAEEPxxTNTQ-ETLEVEI VGLKEKISVKQADAVPLEEARIEDIVSNL----NEKKDPNEAVEELKYRC ALKTALDSLKENVPARQ-Vx------------------------------ -------PSKEGxxxxx--------------------------------- -------------------------------------------------- ------------Sx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxx------------------------ ------xxxxxx-------------------------------------- -------------------------------------------------- ---------xxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------xxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------xxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxx--xxxxxxxxxxxxxxxxxxxxxxxx-xxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxx---------xx--- -------------------------------------------------- --xxxxxxxxx--------xxxxxxxxxxxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxx-xxxxxx----------- --xxx-----------------------------------------xxxx xxxx---------------------------------xxxxxxxxxxxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxx------xxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------xxx------------------ -------------------------------------------------- ----------------xxxxxxxxxxxxxxx------------------- -------------------------------xxx---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- xVMNQAKEFH---------------------------------------- ----------------------------------LPDFx----------- -------------------------------------------x-x-x-x xxPxxxxxxxxxxxxxxxxx------------------------------ -------------------xxx-------xxx------------------ ------------------------------DDEEE--------------- -------------------------------------------------- -----------------------------------LPSILSHQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PESIDEGILVWCKWQRYPYWPAV-------------------------- ----------VKNVKRKHRKANVFFIEGNTGDK-KRSFSVSLRNLKHFDC EEKQDLIDQAKKDYRQEIEWCIQLISDYRIRVGCHSFTGSFLEYFADDIS YPVRKQYRQSFVEMTFPNGAEEDL-E--ESALETSP---xxPS------- -RKLLPDRTRAARDKANKKIVEFIVKTKGAE------------------- --------------------------------------------EHLLAI LKCRKESRWMKDFLSSRQYGSCVETYLEDEEQLDLVVNYLKEVxC-HEGD TANLQRLHGDGVKFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYAISAVDDIDYKKAEEKYMKGPS----- ---------------------------------------VSKR----ERE KFDEEILERRW---LQS--------------------------------- ---------------------xxxxx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSCJPP00005012543 -------------------------------------------------- ----Mx-SG-GYVLYRWKERLWPAKVLPKAGLAEEPxxANAQ-ETLEIEI IGLKERVSVKQEDAVPLEEARIEDIVSNL----SEKVDPIEAVEELKYRC ALKYALDSLKEDVATLE-Vx------------------------------ -------PSKEGxxxxx--------------------------------- -------------------------------------------------- ------------Sx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxx------------------------ ------xxxxxx-------------------------------------- -------------------------------------------------- ---------xxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------xxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------xxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxx--xxxxxxxxxxxxxxxxxxxxxxxx-xxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxx---------xx--- -------------------------------------------------- --xxxxxxxxx--------xx--xxxxxxxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxx-xxxxxx----------- --xxx-----------------------------------------xxxx xxx---------------------------------------xxxxxxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxx------xxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- ------------------------------xxxxxx-------------- xxxxxxxxxxxxxx-----------------xxx---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- xVMDKAKEFH---------------------------------------- ----------------------------------LPxFx----------- -------------------------------------------x-x-x-x xxPxxxxxxxxxxxxxxxxx------------------------------ -------------------xxx-----x-DDD------------------ ------------------------------DDEEE--------------- -------------------------------------------------- -----------------------------------LPSILSHQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PESIDKGILVWCKWQKFPYLPAV-------------------------- ----------VTNVKRKYRKAYVLFIEENMSDKNNKSLSVSLRNLKHFDC KEKQDLIDQAKKDYRQEIEWCIQLISDYRIRVGCHSFTGSFLEYFADDIS CPVKKQYQLSSAQMTFPSIAEEDL-E--DSVLETSP---xxPS------- -RKLLPDRTRAARDKANQKIVEFIVKTKGAE------------------- --------------------------------------------EHLLAI LKCRKESRWMKDFLSSRQHGTCIETYLEDEEQLELVVNYLKEVxY-HEID TSNLQQLLGDGVKFISDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYAISAVDDIDYKEAEEKYMKGPS----- ---------------------------------------VSKR----ERE EFDEEILERKR---LQA--------------------------------- ---------------------xxxxx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSCPUP00000024111 -------------------------------------------------- ----Mx-DQ-EYVLCTWKKRLWPAKVLCKTGAGGKTxxKNAKETSFKVEI LGLKKQISVSRADAVPLKEECIENIASSL----DQRNNSSEAVEELRYRC SLKIALDILNQNISPRE-Vx------------------------------ -------PSExxxx-xx--------------------------------- -------------------------------------------------- ------------Sx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxx------------------------ ------xxxxxx-------------------------------------- -------------------------------------------------- ---------xxxxxxxxxxxxxxxxxxxxx---------------xxxxx -------------------------------------------------- ------------xxxxxxxxxx---------------------------- ----------xxxx------xxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxx--xxxxxxxxxxxxxxxxxxxxxxxx-xxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xxx--------------------------- -------------------------------------------------- --------------xxxx-------------------------------- -------------------------------------------------- ---xxxxx-----------------------xxx-xxx------------ ------------------------------------xxxxxxxxxxxxx- ---------------xxxxxxxxxx------------------------- -------------------------------------------------- ----------------------------xxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxxxxxxxxx----------- --xxx-----------------------------------------xxxx xxxx---------------------------------xxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- ------------------------------xxxxxx-------------- x----------------xxxxxxxxxxxxxxxxx---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- xVTDKVTAFQ---------------------------------------- ----------------------------------LPDFx----------- -------------------------------------------x-x-x-x xxSxxxxxxxxxxxxxxxxx------------------------------ -------------------xxx-----x-EEE------------------ ------------------------------DEDEE--------------- -------------------------------------------------- -----------------------------------LPSILSNQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PQSIEEGMLVWYKLRRYPHWPAV-------------------------- ----------VKKVKRKRRKACVLFIEGSTNDK-KKGFSVSLRSLKHFDC EEKQDLIERAKEDYRQEIEWCIRLISDYRIRVGCRSFTGSFLEYFAADIS YPVRKECCQGLVPMSFPNVAEENI-E--ESSSETSP---xxPS------- -KKLLPDRTRAARDKANKKIVEFIVKTKGAE------------------- --------------------------------------------EHLLAI LKSRKQSRWLKEFLNSSQYVTCVETYLEDEEQLDLVVNYLKEV-Y-CEMG AKNLQQINGDAIKFISDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYAISAVDDIDYKKAEEKYIKGPS----- ---------------------------------------VSKR----ERE IFDEEILERKK---GKR--------------------------------- ---------------------xxxxx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSDNVP00000001810 -------------------------------------------------- ----Mx-DQ-EYVLCKWKKRLWPAKILSKIGVPGKPxxTNAKEASFKVKI LGLEEQTSVNCADTEPLKEEYIQNIASNL----DQGKNSSEAVEELKYRR SLKIALDILNQNDSPRQ-Vx------------------------------ -------PSEDExxxxx--------------------------------- -------------------------------------------------- ------------Sx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxx------------------------ ------xxxxxx-------------------------------------- -------------------------------------------------- ---------xxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxxxxxxxxx---------------- -------------------xxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------xxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxxxxxx--xxxxxxxxxxxxxxxxxxxxxxxx-xxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx-------------------------------------------- ------xxxxxxxx-x---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxxxxxxxxx----------- --xxx-----------------------------------------xxxx xxxx---------------------------------xxxxxxxxxxxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxx------xxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- ------------------------------xxxxxx-------------- xxxxxxxxxxxxxx--x--------------xxx---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- MLRNKVKDFQ---------------------------------------- ----------------------------------LPDFx----------- -------------------------------------------x-x-x-x xxSxxxxxxxxxxxxxxxxx------------------------------ -------------------xLx-----x-EEE------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPSILSHQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PQSIEEGILVWCKLRRYPYWPAV-------------------------- ----------VKTVKRKHRKANVLFIEGNTNDK-TKGFSVSLKNLKHFDC EEKQDLIDQAKEAYCQEIEWCIRLISDYRIRVGCHSFTGSFLEYFADDIS YPVRKEGIQGLVQMSFTNIAEEEL-E--ESPPETSP---xxPS------- -KKLLPDRTRAARDKANKKIVEFIVKTKGAE------------------- --------------------------------------------EHLLAI LKSRKQSRWLKEFLNSSQYVTCVETYLEDEEQLDLVVNYLKQV-Y-HEID TRSLHRINGDGIKFISDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYAISAVDDIDYKKAEEKYIKGPS----- ---------------------------------------VSKR----ERE IFDEEILGRKK---WKT--------------------------------- ---------------------xxxxx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSAOWP00000020710 -------------------------------------------------- ----Mx-DQ-EYVLCKWKKRLWPAKILSKTGVPGKPxxTNAKEISFKVEI LGLEEQASVNCADTEPLKEECIQNIASNL----DQGKNSSEAVEELKYRR SLKIALDILNQNDSPRE-Vx------------------------------ -------PSEEExxxxx--------------------------------- -------------------------------------------------- ------------Sx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxx------------------------ ------xxxxxx-------------------------------------- -------------------------------------------------- ---------xxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxx--xxxxx---------------- -------------------xxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------xxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxx--xxxxxxxxxxxxxxxxxxxxxxxx-xxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx-------------------------------------------- ------xxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxxxxxxxxx----------- --xxx-----------------------------------------xxxx xxxx---------------------------------xxxxxxxxxxxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxx------xxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- ------------------------------xxxxxx-------------- xxxxxxxxxxxxxx--x--------------xxx---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- MLRNKVKDFQ---------------------------------------- ----------------------------------LPDFx----------- -------------------------------------------x-x-x-x xxSxxxxxxxxxxxxxxxxx------------------------------ -------------------xLx-----x-EEE------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPSILSHQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PQSIEEGILVWCKLRRYPYWPAV-------------------------- ----------VKKVKRKHKKANVLLIEGNTNDK-TKGFSVSLRNLKHFDC EEKQDLIDRAKEAYCREIEWCIRLISDYRIRVGCHSFTGSFLEYFADDIS YPVRKEGIQGLVQMTFTNVAEEEL-E--ESSSETSP---xxPS------- -KKLLPDRTRAARDKANEKIVEFIVKTKGAE------------------- --------------------------------------------EHLLAI LKSRKQSRWLKEFLNSSQYVTCVETYLEDEEQLDLVVNYLRQV-Y-HERG TRNLHRINGDGIKFISDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYAISAVDDIDYKKAEEKYIKGPS----- ---------------------------------------VSKR----ERE IFDEEILERKR---WKT--------------------------------- ---------------------xxxxx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSABRP00000001208 -------------------------------------------------- ----Mx-DP-EYVLCKWRKRLWPAKVLCKSGDVGKSxxANAEEASLEVEI LGLKEKVSVSSADTVPLSEEGIEDIASNL----xxxxNASEVVDELKYRC ALRTALDFLSENASARQ-Vxxxxxxx------------------------ ------xx-------xx--------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxx------------------------ ------xxxxxx-------------------------------------- -------------------------------------------------- ---------xxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxx---------------- -------------------xxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxx- xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------xxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxx--xxxxxxxxxxxxxxxxxxxxxxxx-xxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxx-xxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxx----------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxx-xxxxxx----------- --xxx-----------------------------------------xxxx xxxx---------------------------------xxxx--------x xxx-------------------xxx------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxxxxxx------xxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- ------------------------------xxxxxx-------------- xxxxxxxxxxxxxx--x--------------xxx---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- xxxxxxxxxx---------------------------------------- ----------------------------------xxxxx----------- -------------------------------------------x-x-x-x xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------xxx-----x-xxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPSILSRQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PQLIEEGILVWCKWQRYPYWPAV-------------------------- ----------VRKVKRKHRKANVLFIEGNVNDK-KKGFSVSLKSLKHFDC EEKQDLIDQAKEEHRQEIEWCIQLISDYRIRVGCHSFTGSFLEYFADDIS YPVRKQCYQGLVQMTFPNVAEENL-E--ESLSETSP---QKPS------- -KKLLPDRTRAARDKANKKIVEFIVKTKGAE------------------- --------------------------------------------EHLLAI LKSRKQSRWMKEFLNSSQYVTCIETYLEDEEQLDLVVNYLKEV-Y-HEMD TENLRQINGDRIKFISDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYAISAVDDIDYKKAEEKYIKGPS----- ---------------------------------------VSKR----ERE KFDEEILERKK---LKT--------------------------------- ---------------------xxxxx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSCPBP00000032721 -------------------------------------------------- ----Mx-DQ-EYILCKWKNRLWPAKVLCKIRTSGKPxxPKAKAASFKVEI LGLEEQTNVNCTDTEPLEEERIKIIASEL----DQRNKPSHPVEELKYRK ALKIALDILSA--xxxx-xx------------------------------ -------xxxxxxxxxx--------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxx----xxxxx-------------------xxxxxx------- ---------xxxx------------------------------------- -------------------------------xxx---------------- -------------------xxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------xxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx-------------------------------------------- ------xxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxx-------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxYKMLDG SKKP--------------xxxxxxxxxxxxxxxxxx------xxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- ------------------------------xxxxxx-------------- xxxxxxxxxxxxxx--x--------------xxx---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- xPVNKTKNCQ---------------------------------------- ----------------------------------LPDFx----------- -------------------------------------------x-xxx-x xxSxxxxxxxxxxxxxxxxx------------------------------ -------------------xLx-----xxxxx------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPSILLRQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCSIEPGMLVWCKLRRYPYWPAV-------------------------- ----------IKRVTRKYKKANVLLIEAGMNNKKTKGFSIGLKNLKHFDC KEKQKLIDKAKEDYSQEIEWCIELIADYRIRVGCRSFTGSFLEYCADDIS YPVRKEVNQGKLQMTFPVIAEEDL-E--ESVSETPP---xxPS------- -KKVLPDRTRAARDKANSKIVDFIVKTKGAE------------------- --------------------------------------------EHLLAI LKSKKQSRWLREFLNSSQYMTC-ETYLEDEEQLDRVVNYLQEV-C-HEID TRKLDVKNGDRIKFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYAISAVDDIDYKKAEEKYIKGPS----- ---------------------------------------VSKR----ERE IFDTEILEKKKxxxxxx--------------------------------- ---------------------xxxxx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSCABP00000005079 -------------------------------------------------- ----Mx-DQ-EYILCKWKNRLWPAKVLCKIRTSRRPxxSKAEAASFKVEI LGLEEETYVNYVDTEPLEEERIKIIASEL---ADQRxKPTHPVEELKYRK ALKIALDILSA--xxxx-xx------------------------------ -------PSDEGxxxxx--------------------------------- -------------------------------------------------- ------------Gx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxx----xxxxx-------------------xxxxxx------- ---------xxxx------------------------------------- -------------------------------xxx---------------- -------------------xxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------xxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx-------------------------------------------- ------xxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxx-------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxYKMLDG SKKP--------------xxxxxxxxxxxxxxxxxx------xxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- ------------------------------xxxxxx-------------- xxxxxxxxxxxxxx--E--------------xxx---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- xPVNKAKNCQ---------------------------------------- ----------------------------------LPxFx----------- -------------------------------------------x-xxx-x xxSxxxxxxxxxxxxxxxxx------------------------------ -------------------xxx-----xxxxE------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPSILLRQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCSIEPGMLVWCKLPRYPYWPAV-------------------------- ----------IKRVTRKYKKASVLLIEAGMNDKKAKGFSIGLKNLKHFDC KEKQNLIDKAKEDYSREIEWCIELIADYRIRVGCRSFTGSFLEYCADDIS YPVRKEVNQGKIQMTFPVIAEEDF-E--ESLSETTP---xxPS------- -KKVLPDRMRAARDKANSKIVDFIVKTKGAE------------------- --------------------------------------------AHLLAI LKSKKQSRWLREFLNSSQYMTC-ETYLEDEEQLDLVVNYLQEV-C-HEID TRKLDLKNGDRIKFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYAISAVDDIDYKKAEEKYIKGPC----- ---------------------------------------VSKR----ERE IFDKEILEKKKxxxxxx--------------------------------- ---------------------xxxxx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSGAGP00000019390 -------------------------------------------------- ----Mx-DQ-EYILCKWKNRLWPAKVLCKIRTSRRPxxSKAKAASFKVEI LGLEEQTNVNCVDTQPLEEERIKIIASEL----DQRNKPSHPVEELKYRK ALRIALDILSA--xxxx-xx------------------------------ -------xxxxxxxxxx--------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxx----xxxxx-------------------xxxxxx------- ---------xxxx------------------------------------- -------------------------------xxx---------------- -------------------xxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------xxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx-------------------------------------------- ------xxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxx-------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxYKMLDG SKKP--------------xxxxxxxxxxxxxxxxxx------xxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- ------------------------------xxxxxx-------------- xxxxxxxxxxxxxx--K--------------xxx---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- xPVNKAKNCQ---------------------------------------- ----------------------------------LPxFx----------- -------------------------------------------x-xxx-x xxSxxxxxxxxxxxxxxxxx------------------------------ -------------------xxx-----xxxxE------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPSILLRQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCSIEPGMLVWCKLPRYPYWPAV-------------------------- ----------IKRVTRKYKKASVLLIEAGMNGKKAKGFSIGLKNLKHFDC KEKQNLIDKAKEDYSREIEWCIELIADYRIRVGCRSFTGSFLEYCADDIS YPVRKEVNQGKIQMTFPVIAEEDF-E--ESLSETTP---xxPS------- -KKVLPDRMRAARDKANSKIVDFIVKTKGAE------------------- --------------------------------------------AHLLAI LKSKKQSRWLREFLNSSQYMTC-ETYLEDEEQLDLVVNYLQEV-C-HEID TRKLDVKNGDRIKFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYAISAVDDIDYKKAEEKYIKGPC----- ---------------------------------------VSKR----ERE IFDKEILEKKExxxxxx--------------------------------- ---------------------xxxxx------------------------ -xx----------------------------------------------- --x-------------------------------------------- >ENSPSIP00000002867 -------------------------------------------------- ----Mx-DQ-EYILCKWKNRLWPAKVLSKIRTSRKPxxSKAKAASFKVEI LGLEEQTNVNSTDTEPLEKEHIQRIASEL----DQKNKPRHPVEELKYRK ALKIALDILSN--xxxx-xx------------------------------ -------SSDDRxxxxx--------------------------------- -------------------------------------------------- ------------Tx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx x-xxxxxxx----xxxxx-------------------xxxxxx------- ---------xxxx------------------------------------- -------------------------------xxx---------------- -------------------xxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- ------------x------------xxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---- -------------------------------------------------- -------xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx-------------------------------------------- ------xxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- ----x--------------xxxxxxxxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxx-------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxIKILDG SRET--------------xxxxxxxxxxxxxxxxxx------xxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- ------------------------------xxxxxx-------------- xxxxxxxxxxxxxx--x--------------x-x---------------- -------------------------------------------------- ------------xxxxxx-------------------------------- xPVNKAKNCQ---------------------------------------- ----------------------------------LPxFx----------- -------------------------------------------x-xxx-x xxSxxxxxxxxxxxxxxxxx------------------------------ -------------------xLx-----x-EDE------------------ ------------------------------EEDEE--------------- -------------------------------------------------- -----------------------------------LPSILLRQE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -PCSIEPGMLVWCKLPRYPYWPAV-------------------------- ----------IKSVKRKYKKANVLLIEGGMNAKKAKGFSTGLKNLKHFDC EEKQKLTDKAKEDYSQEIKWCIKLIADYRIRVGCRSFTGSFLEYCADDIS YPVRKEVNQGRVPMSFPNIAEEDL-E--ESVSETTP---xxPS------- -KKVLPDRTRAARDKANSKIVDFIVKTKGAE------------------- --------------------------------------------EHLVAI LKSKKQSRWLREFLNSSQYMTC-ETYLEDEEQLDLVVNYLQEV-C-HEID TRKLDVKNGDRIKFILDVLLP-------E--------------------- -------------------------------------------------- -----A-------------------------------------------- --------------------IIYAISAVDDIDYKKAEEKYIKGPS----- ---------------------------------------VSKRxxxx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --x--------------------------------------------