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--APGTAGLEFRRLIHIEQQANGGASVVHAYNEELACLSPAEMQRFADEFVTLSFSDD-E AQAACFVMGIIHGAASYLPDFLDYFSYKFPNAPVKMEVLGKKDIETTTMANFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFISMLEKSPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPLADMPKSPFKRK-------RSTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTAARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHNDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------HEE----------------K--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- ------------VKEE----------------------------------------E--- -------------------------------------TCSPRQVTCYIKK---------- ------------------------------------------------------------ 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SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFISMLEKSPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTPERITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHNDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------HEG----------------K--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- ------------VKEE----------------------------------------E--- -------------------------------------TCSPREVTCYIKK---------- ------------------------------------------------------------ ------------------------------------------------------EEE--- -----------------EE----------------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLIAKRPPE-SRPQSSSD----------------IF--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRKLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TAVA--------VPT------ -------------------------------------------------TPVRK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPHKV----------------------KKAKEKRHKE----K------------- -----EKS---------------------------------------------------- ----------------------------------SGAQQSP--SAAVERVSPASCH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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----------LNRINVNSDS------------SSLNHSAA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------QH--HQDAAV SA---------------------------------------------------------- -----------------------------ATSTSISSMVRERLSYNSPLH---------- -------------------------CS--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --APGMAGLEFGRLIHVEQQANGGAYVVHAYNEELACLSPAEMQRFADEFVTLSFSED-E AQAACFVMGIIHGAASYLPDFLDYFSYKFPNAPVKMEVLGKKDIETTTMANFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFISMLEKSPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHNDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------HEE----------------K--------- ------------------------------------------------------------ -----ED----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------DEE E----------------------------------------------------------- ------------VKEE----------------------------------------E--- -------------------------------------T---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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-------------AESVDSMHFA------------------------------------- ANSKTNSPKPLIAKRPPE-SRPQSSSD----------------IF--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRRLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TAAA--------VPA------ -------------------------------------------------TPARK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPPKV----------------------KKAKEKRHKE----K------------- -----EKS---------------------------------------------------- ----------------------------------SEAQRSS--AVAVEKVSPASCH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDVK----------------------------------------ML----- ------------------------------------------------QR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---HRV------------------------------- ------------------K-EKDR----EKKKE----------------------KNK-E -WKNHK-LPPVHDIARENGEVISPQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-SKEKPKAGSEEDLLLKKLKKKKKKKHKDGERVKERHS----------------- -------------R----PKMYHRSCQTVCSGVS-------------------------- ------------------------------LGLPE------------------------- ---------------------------------------FLTRINGNN------------ --------------------------------------------S----S-SLIHST-A- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------P-QH--HQDPAV TA---------------------------------------------------------- -----------------------------A--TSISSMVRDRLGYSSPLH---------- -------------------------CT--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --APGLHGLEFGRLIHIEQQANGGASVAHAYSEQLSCLSPAEMQRFAQEFVTLSFSED-E AQAACFVMGIIHGAASYLPDFLDYFSYKFPNAPVKMEVLGKKDIETTTMANFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFINMLEESPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDAPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------HEE----------------K--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- --------------EE----------------------------------------E--- -------------------------------------KCSPRDVTLHIKE---------- ------------------------------------------------------------ ------------------------------------------------------EEE--- -----------------DE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----EVEGKECDLA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VTTKLE-------------DEDEEGREGPASQTP-TRIFKEEDRES RAEIKE--SSQSLALVKRERDEGVHTATLMEPKPE------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------A-EDGRG ----GADTCPTPQKGNEEAGVDGAFFKSLQQNRKESEVEEDRQQKTSVQGQGLKDKSKDG TSSIYNTP---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------QI K--------------------------------------KDKGK---------------- ---RER-------------------DEKERAK---------------------------- ---------------------DKEK--KDRSKE---------KDRDKKDRGKDR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------EKE--RGREQERGKAEGG--------------------- ------------------------------------------------------------ -----REG--SSLMQPQIKKKED------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTREGSKTS-QTNPPAQRDEKWA-KEW DSK-TQ-AHVKREKEHDKDRGGSQ-A--------------------------AAHFRPDR EEAQNSCTHKHK-SSHGKKEK----------------------------SGHREAKD--- -----------------------GSTS--QGMQAKS------------------------ ---------------------------AR-EDGK--TPKAAHFQVKKESKKEKD------ ----------------VSGGREEKKKPTSGPA--QPEHK----Q---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTLVTFDLFK----------------------- -------------------------------------------------P-MEAHQTLAL SFT----------------------D-SRP-KT------HH------------------- ------------------------------------------------------------ --HSDSRGS--------------------------------------------------- -----------------------------------SSK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ---RTVV-----------------PS-----------------KGPKV------------ ------------------------------------------------------------ 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--------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRRLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TAAA--------VPA------ -------------------------------------------------TPARK------ -----------------------IFKISNFL----------------------------- 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------------------------------------------------------------ ----------------------D---HRV------------------------------- ------------------K-EKDR----EKKKE----------------------KNK-E -WKNHK-LPPVHDIARENGEVISPQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-SKEKPKAGSEEDLLLKKLKKKKKKKHKDGERVKERHS----------------- -------------R----PKMYHRSCQTVCSGVS-------------------------- ------------------------------LGLPE------------------------- ---------------------------------------FLTRINGNN------------ --------------------------------------------S----S-SLIHST-A- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------P-QH--HQDPAV TA---------------------------------------------------------- -----------------------------A--TSISSMVRDRLGYSSPLH---------- -------------------------CT--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --APGLHGLEFGRLIHIEQQANGGASVAHAYSEQLSCLSPAEMQCFAQEFVTLSFSED-E AQAACFVMGIIHGAASYLPDFLDYFSYKFPNAPVKMEVLGKKDIETTTMANFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFINMLEESPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDSPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------HEE----------------K--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE EE---------------------------------------------------------- ------------VKEE----------------------------------------E--- -------------------------------------KCSPRDVTLHIKE---------- ------------------------------------------------------------ ------------------------------------------------------EEE--- -----------------DE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----EVEEKESDLA--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------A-EDGKG ----GADSCPTPQKGHEEAGVDGAFFKSLQQNRKESDVEEERQQKTSLQGQGLKDKSKDS TSSFYNTP---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------QI KKE------------------------------------KDKGK---------------- ---RER-------------------DEKERAK---------------------------- ---------------------EKEKKDKDRSKE---------KERDKKDRGKDR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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--------------------------PRTLVTFDLFK----------------------- -------------------------------------------------P-MEAHQTLAL AFT----------------------D-SRP-KT------HH------------------- ------------------------------------------------------------ --HSDSR----------------------------------------------------- -----------------------------------ASK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ---RTVV-----------------PS-----------------KGPKV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------S-------------MQGRPAS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -ALQDTG----------------------------------------------------- --------------------------------PQQH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SLKQ------------------------------ ----------------------------------P----------------------LKT HT-------P-------------------------------------------------- -------------------------QPQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSAOCP00000008318 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLIAKRPPE-SRPQSSSD----------------IF--PPA---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRRLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHP---------TAAA--------VPA------ -------------------------------------------------TPARK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPPKV----------------------KKAKEKRHKE----K------------- -----EKS---------------------------------------------------- ----------------------------------SEAQRSS--AAAVEKVSPASCH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDVK----------------------------------------MP----- ------------------------------------------------QR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---HRV------------------------------- ------------------K-EKDR----EKKKE----------------------KNK-E -WKNHK-LPPVHDIARENGEVISPQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-SKEKPKAGSEEDLLLKKLKKKKKKKHKDGERVKERHS----------------- -------------R----PKMYHRSCQTVCSGVS-------------------------- ------------------------------LGLPE------------------------- ---------------------------------------FLTRINGNN------------ --------------------------------------------S----S-SLIHST-A- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------P-QH--HQDPAV TA---------------------------------------------------------- -----------------------------A--TSISSMVRDRLGYSSPLH---------- -------------------------CT--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --APGLHGLEFGRLIHIEQQANGGASVAHAYSEQLSCLSPAEMQRFAQEFVTLSFSED-E AQAACFVMGIIHGAASYLPDFLDYFSYKFPNAPVKMEVLGKKDIETTTMANFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFINMLEESPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDSPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------HEE----------------K--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------A-EDGKG ----GADSCPTPQKGHEEAGVDGAFFKSLQQNRKESDVEEERQQKTSLQGQGLKDKSKDS TSSFYNTP---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------QI KKE------------------------------------KDKGK---------------- ---RER-------------------DEKERAK---------------------------- ---------------------EKEKKDKDRSKE---------KERDKKDRGKDR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------EKE--RVREQERVKAEGG--------------------- ------------------------------------------------------------ -----REG--SSLMMPQIKKKED------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTREGSKTS-QSNPPAQRDEKWA-KEW DSK-TQ-PHIKREKEHDKDRGGSQ-A--------------------------AAHFRPDR EEAQNSCTHKHK-SSHGKKEK----------------------------SGHREGKD--- -----------------------GSTS--QGMQAKS------------------------ ---------------------------GR-EDGK--TPKPAHFQVKKEGKKDKD------ ----------------VVSSREEKKKPTSGPA--QPEHK----Q---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTLVTFDLFK----------------------- -------------------------------------------------P-MEAHQTLAL 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---D-------------------------------------------------------- --------------------------------------------------------FLI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSSPAP00000030258 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLIAKRPPE-SRPQSSSD----------------IF--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRRLNGE---------------------------------- 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-------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --PPGLPGLEFGRLIHIEQQANGGASVAHAYSEQLSCLSPAEMQRFAQEFVTLSFSED-E AQAASFVMGIIHGAASYLPDFLDYFSYKFPNAPVKMEVLGKKDIETTTMANFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFISMLEESPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------HEE----------------K--------- ------------------------------------------------------------ -----DE----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------EEE 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------------------------------------------------------------ -----------------------------------------------------ATEDGKG ----GADTCPTLQRGHEEAGVDGASLKSLQQNRKESDVEEERQQKTPLPGQGLKDKSKDS TSSTYSAP---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------QI KKE------------------------------------KDKGK---------------- ---REK-------------------DEKERAK---------------------------- ---------------------EKEK--KDRSKE---------KDRDKKDRGKDR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DREKDRVREQERAKAEGG--------------------- ------------------------------------------------------------ -----RDG--STPMLPPIKKKED------------------------------EE----- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-STEKPKAGSEEDLLLKKLKKKKKKKHKDGERVKERHS----------------- -------------R----PKMYHRSCQTVCSGVS-------------------------- ------------------------------LALPD------------------------- ---------------------------------------FLSRINGNNNSINSSNLH--- ------------------------HSTA---------------AS----Q---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------QH--HQDPPV TA---------------------------------------------------------- -----------------------------ATSASISSMVRERLSYSSPLH---------- -------------------------CT--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --VPSVSGLEFGHLIHIEQQANGGASVAHAYSEQLSYLSPAEMQRFAQEFVTLSFSED-E AQAACFVMGIIHGAASYLPDFLDYFSYKFPNAPVKMEVLGKKDIETTTMANFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFINMLEESPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSYTPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------HEE----------------E--------- ------------------------------------------------------------ -----K------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- --------------EE----------------------------------------EVKE GE----------------------------------EKCALREVTLNIKE---------- ------------------------------------------------------------ ------------------------------------------------------EEE--- -----------------DE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----EIE---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------EEFDPAVQTVTKLEDEEAEGREGPPSQTP-TQIFKEEEQEN 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EGDKDADACQTLQKGHEEGGVDSASLKSLQQIRKENDVEEERQQKTTVPGQGLKEKTKDS ITSTYNTA---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------QI KKE------------------------------------KEKGK---------------- ---REK-------------------DEKERVK---------------------------- ---------------------EKEKKDKDRTKE---------KEKDRKDRGKDR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DREKDRVREQERVKAEGG--------------------- ------------------------------------------------------------ -----REGSTSTQPLPQIRKKED------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTKEGSKAS-QTSLPAQRDEKWA-KEW DSK-TQ-PHVKREKEHDKDRGGTQGA--------------------------ASHLRPDR EEARDACSHKHK-SSHGKKEK----------------------------SGHREGNA--- -----------------------GST---QTVQAKS------------------------ ---------------------------GR-EDGKTGTPKPANIQVKKEAKKD-------- -----------------VNSKEERKKAASGPA--PPEHK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTLITFDLFK----------------------- -------------------------------------------------P-MEAHQTLAL SFT----------------------D-SRP-KA------HH------------------- ------------------------------------------------------------ --HSDSRGS--------------------------------------------------- -----------------------------------SSK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DT-------------------------------- ------------------------------------------------------------ ---RTVV-----------------PS-----------------KGPKV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------T-------------AQGKPAT-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -PVQDTR----------------------------------------------------- --------------------------------PQQH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SLKQ------------------------------ ----------------------------------P----------------------LKT HT-------P-------------------------------------------------- -------------------------QSQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSLCAP00010030838 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLIAKRPPE-SRPQSSSD----------------IY--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRKLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ 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--VPGLPGLEFGRLIHIEQQANGGASVAHAYSEQLSALSPAEMQRFAQEFVTLSFSED-E AQAACFVMGIIHGAASYLPDFLEYFSYKFPNAPVKMEVLGKKDIETTTMANFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFISMLEESPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPLADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDGDTPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------HEE----------------K--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- --------------EE----------------------------------------E--- -EEEE---------------------------GKKEEKCAHTEVTLHIKE---------- ------------------------------------------------------------ ------------------------------------------------------EEE--- -----------------DEEE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---DDEVEGKECD----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------PAAQTVTKPEEEDAEGAEGPPSQTP-TQIFKEEEQEN RAETKELSTTQSVPLVKKERDEGDLTHTLTEIKDE------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------ENEKEEGSG GGDRGADTCQTLQKGHEESGGDSASLKSLQQIRKENDVEEEKQQKMTLPGQGLKEKTKDS ITTT---A---------------------------------------------------- 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DSK-TQ-AHVKREKEHDKDRGGAQ-A--------------------------ASHSRPDR EEARDVCLHKHK-SLHGKKEK----------------------------SGHREGKE--- -----------------------SNTSSTQGAQVKP------------------------ ---------------------------GR-EDGKTGAPKPANIQVKKEGKKDKD------ -----------------VSSKDERKKSSSGPT--PPEHK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTLITFDLFK----------------------- -------------------------------------------------P-MEAHQTLAL SFT----------------------D-SRP-TT------HH------------------- ------------------------------------------------------------ --HSDSRGS--------------------------------------------------- -----------------------------------SSK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ---RTVV-----------------PS-----------------KGPKV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------S-------------VQGKPAT-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -PLQDTR----------------------------------------------------- --------------------------------PQQH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SLKQ------------------------------ ----------------------------------P----------------------LKT HT-------P-------------------------------------------------- -------------------------QTQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSSLDP00000031830 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLIAKRPPE-SRPQSSSD----------------IY--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRKLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------AAAA--------GPA------ -------------------------------------------------TPARK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPLKV----------------------KKAKEKRHKE----K------------- -----EKG---------------------------------------------------- ----------------------------------GEAQRSS--AAGVERVSPASCH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDVK----------------------------------------ML----- ------------------------------------------------QK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---HRV------------------------------- ------------------K-EKDR----EKK------------------------KNK-E -WKNHK-LPPVHDIARENGEVISSQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-PKEKPKAGSEEDLLLKKLKKKKKKKHKDGERVKERYS----------------- -------------P----PKMYHRSCQTVCSGVS-------------------------- ------------------------------LGLPE------------------------- ---------------------------------------FLSRINGNN------------ --------------------------------------------SID-GS-GLLHTTTA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------PQQH--HQDPPV TA---------------------------------------------------------- -----------------------------ATSTSISSMVRDRLGYNSLLH---------- -------------------------CT--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --APGLPGLEFGHLIHIEQQANGGASVVHAYSEQLSSLSPAEIQRFAQEFVTLSFSED-E AQAACFVMGIIHGAASYLPDFLDYFSYKFPNAPVKMEVLGKKDIETTTMVNFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFISMLQESPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPLADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDAPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------HEE----------------K--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- --------------EE----------------------------------------E--- -EDVK---------------------------G---EKCTHTEVTLHVKE---------- ------------------------------------------------------------ ------------------------------------------------------EEE--- -----------------DE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----EVQRKECH----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------PAVHTVTKLEEEDNEGGEGPLSQTP-TQIFKEEAQEN RVDMKELSTAHSVPFVKKERDEGLLTHTLMEPKAE------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EKEEGKG AGDRGADTYQTLQKGHEEGEVDSASFKTLQHIRKENDVEEERQQKMTLPGQGLKEKTKDS ITTTYNPP---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------PI KKD------------------------------------KDKGK---------------- ---REK-------------------DERERP----------------------------- ----------------------KDKKDKDRSKE---------KERDKKERGKEK------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DREKDRMREQEKVKGEGG--------------------- ------------------------------------------------------------ -----REGSTSTQPLPQIRKKED------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTREGSTAS-QTSLPAQRDEKWA-KEW DSK-TQ-PHVKREREHDKDRGGTQ-A--------------------------ASHLRPDK EEARDACSHKHK-SSHGKKEK----------------------------SGNREGKE--- -----------------------SNTSSTQGVQAKS------------------------ ---------------------------GR-EDGKTGTPKPSNIQVKKDGKKDKD------ -----------------VSSKDERKKSSSGPT--PPEHK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTLITFDLFK----------------------- -------------------------------------------------P-MEAHQTLAL SFT----------------------D-SRT-KT------HQ------------------- ------------------------------------------------------------ --HSDSRGS--------------------------------------------------- -----------------------------------SSK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ---RTVV-----------------PS-----------------KGPKV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RD----------S-------------VQGKPAT-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -PLQDTR----------------------------------------------------- --------------------------------PQQH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SLKQ------------------------------ ----------------------------------P----------------------LKT HT-------P-------------------------------------------------- -------------------------QTQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCGOP00000025645 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AEAVDSMHFA------------------------------------- ANSKTNSPKPLIAKRPPE-SRPQSSSD----------------IY--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRKLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TAAA--------VPA------ -------------------------------------------------TPARK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPHKV----------------------KKAKEKRHKE----K------------- -----EKS---------------------------------------------------- ----------------------------------SEAQRSS--AAGVERVSPASCH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDVK----------------------------------------ML----- ------------------------------------------------QR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---HSA------------------------------- ------------------N-EKDG----EKKKE----------------------KSK-E -WKNHK-LPPVHDIARENGEVISPQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-S-EKPKAGSDEDLLLKKLKKKKKKKHKDGERVKERHS----------------- -------------R----PKMYHRSCQTVCSGVS-------------------------- ------------------------------LGPPD------------------------- ---------------------------------------FLGRVNGNN------------ --------------------------------------------SID-SS-SLLHNTTAA A--------------APP------------------------------------------ ------------------------------------------------------------ ----------------------------------------------PPPQQH--HQDPAV AA---------------------------------------------------------- -----------------------------ATSASISSMVRDRLSYSSPLH---------- -------------------------CT--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --APGLSGLEFGRLIHIEQQANGGASVAHAYTEQLSGLSAAEMQRFAQEFVTLSFSED-E AQAACFVMGIIHGAASYLPDFLDYFSFKFPNAPVKVEVLGKKDIETTTMVNFLAQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFINMLEESPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDAPGRITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------HEE----------------K--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------E- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------VKEEKCAPREVPLHIKE---------- ------------------------------------------------------------ ------------------------------------------------------EED--- -----------------EEEEDEE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------E-------------------------------EDE------------------- EVDDEEVQGKECD----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------PAVQTVTKLEDEDSEGGEEPPSQTP-THIFKEEEQDN RAEMKGVSSTQSLPFGKKEKDEGVLTRTPMEPKAE------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EKEKGKG GGD--GDTCQALQKGHEEGGVDSSSLKSTQQIRKENYVEEERQQKTTVPDQGLKEKTKDS IMSTYNTL---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------HI KKE------------------------------------KEKGK---------------- ---REK-------------------DDKERVK---------------------------- ---------------------DKEKRDKDRSKE---------KERDKKDRGKDR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DREKDRVREQEKVKVEGG--------------------- ------------------------------------------------------------ -----REGGTPTQPLQQMRKKED------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTREGSKAS-QTSMPAQRDEKWS-KEW DSK-TQ-PHVKREKEHDKDRGGSQ-G--------------------------ASHLRPDR EEARDACSHKHK-SSHGKKEK----------------------------SGHREG----- ------------------------NTSSMQG--AKS------------------------ ---------------------------GR-EDGKTGTPKPANIQVKKDGKKDKD------ -----------------VNSKEERKKSASCPA--PPEHK----Q---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTLITFDLFK----------------------- -------------------------------------------------P-MEAHQTLAL SFT----------------------D-SRP-KT------HH------------------- ------------------------------------------------------------ --HSDSRGS--------------------------------------------------- -----------------------------------SSK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ---RTVV-----------------PS-----------------KGTKA------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------T-------------VQGKPAT-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -PLQDTR----------------------------------------------------- --------------------------------PQQH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------LLKQ------------------------------ ----------------------------------P----------------------LKT HT-------P-------------------------------------------------- -------------------------QTQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSGACP00000015950 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------ERHS----------------- -------------R----PKMYHRSCQTVCSGVS-------------------------- ------------------------------LGPPE------------------------- ---------------------------------------FLGRINGNN------------ --------------------------------------------SVN-SS-GLLRASSA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------PQQH--REPPAV ------------------------------------------------------------ -------------------------------SASITSMVRERLGYSSPLH---------- -------------------------CT--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --SPGLSGLEFGRLIHVEQQANGGASVAHAYTEQLSALSPAEMQRFAQEFVALSFSED-E AQAARFVMGIVHGAASYLPDFLDYFSYKFPNAPVKMEVLGKKDIETTTMVNFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFITMLEESPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDAPGRITKDVVCFHAGDFPEVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVAAVCS LAWHIRLKQYHQ-------------------HEE----------------K--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KCALREETFHIIVKKERE EETVGLRATTTVTPEAPPPN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPRNP00000011730 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLIAKRPPE-SRPQSSSD----------------IF--PPP---------- --------------------------------------------------I--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKQRKLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TAAA--------VPA------ -------------------------------------------------TPARK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPPKV----------------------KKAKEKRH------K------------- -----EKS---------------------------------------------------- ----------------------------------SEAQRSS--VAGMEKVSPASCH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDVK----------------------------------------ML----- ------------------------------------------------QK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---HRG------------------------------- ------------------K-EKNR---EEKKKE----------------------KNK-E -WKNHK-LPPVHDIARENGEVISPQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-PKEKPKAGSEEDLLLKKLKKKKKKKHKDGERVKERHS----------------- -------------R----PKMYNRSCQTVCSGVS-------------------------- ------------------------------LALPD------------------------- ---------------------------------------FLSRINGNN------------ --------------------------------------------S----S-SLIHTT--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------P-QH--HHDPAV TA---------------------------------------------------------- -----------------------------ATSTSM-SVVRDRLGYSSPHL---------- -------------------------CT--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --APGLPGMEFGHLIHIEQQANGGASVVHAYNEQLSCLSPAEMQRFAQEFVSLSFSED-E APAACFVMGIIHGAASYLPDFLDYFSYKFPNAPVKMEVLGKKDIETTTMVNFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFISMLEESPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------HEE----------------E--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE K----------------------------------------------------------- ------------------------------------------------------------ ---------------------------------VNEEKCSPTNIILHIKE---------- ------------------------------------------------------------ ------------------------------------------------------EEE--- -----------------EAED--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------GKECDLAL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------QTVTKLEDEDIKGREGLPSQTP-TQIFKEEEQEN RAEMKELSATQSLPSVKKERDEGELTPTLIEPKAE------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EDA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------SK------------------------GVE-------- ------DACQALQKGLEEGGADSASLKSLQQNRKESDAEEDRQQKTSLLGQGLKDKSKDG TTSTYNAP---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------QI KKE------------------------------------KDKVK---------------- ---REK-------------------DEKERA----------------------------- ----------------------KEKRDKDRSKE---------KEKDKKDRVKDK------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DREKDRVREQEKVKADGG--------------------- ------------------------------------------------------------ -----RDSSTMMQ--PQMRKKED------------------------------ED----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTREGSKTSTQTALPAQRDEKWA-KEW DSK-SQ-HHVKREKEPDKDRGALQ-A--------------------------ASHSRPDK EDARDSCSHKHK-SSHGKKEK----------------------------SGHREGKE--- -----------------------GNTS---GLQAKS------------------------ ---------------------------GR-EDGK--TPKTANLQVKKEGRKDKD------ ----------------VSSSKEEKKRPTS--A--QPEHK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTLVTFDLFK----------------------- -------------------------------------------------P-MEAHQTLAL SFT----------------------D-SRP-KT------HH------------------- ------------------------------------------------------------ --HSDSRGS--------------------------------------------------- -----------------------------------SSK--------------LGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ---RTVV-----------------SS-----------------KGPKM------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------S-------------VQGKPAT-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -VLQD------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SLKQ------------------------------ ----------------------------------P----------------------LKT HT-------P-------------------------------------------------- -------------------------QTQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSACIP00000005892 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MHFA------------------------------------- ANSKTNSPKPLIAKRPPE-TRPQSSSD----------------IF--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKIRVEEK-GLKHRKLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TAVA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------EKPKSGSEEDLLLKKLKKKKKKKHKDGERAKERHG----------------- -------------R----PKMYHRSCQTVCSGVS-------------------------- ------------------------------LGLPE------------------------- ---------------------------------------FLSQINANNDSI--------- ---------------------------------------------------SLIHST--- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SP--H--HQDPAV TA---------------------------------------------------------- -----------------------------ATSSSISSMVRERLSYSSPLH---------- -------------------------CS--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --VPGLPGLEFGHLIHIEQQANGGASVVHAYNEELSCLSPVEMQRFADEFVTLSFSED-K AQAACFVMGIIHGAASYLPDFLDYFSYKFPNSPVKMEVLGKKDIETTTMANFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFIDMLEKSPFLERTLPWGTFSSLQLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHNDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------HEE----------------K--------- ------------------------------------------------------------ -----G------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EN EE---------------------------------------------------------- ------------VKEE----------------------------------------E--- -------------------------------------RFSPREVTCHIKK---------- ------------------------------------------------------------ ------------------------------------------------------EEE--- -----------------ED----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----EVEETECDFAVKTVMKLEDEDD--------------------------------- --------------------------------------VGGRE----------------- ------------------------------------------------------------ --EP-------------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------PSDT------- LTPIFKEEERENRADVKELSAAQSLPLVKKERYEAALTPTLTEPQA-----EEGKGAADT CQTLQKDHEEGDR----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VDSSSSKSLQQIRKESDVEEERQHKTS--GQGLKEKSKES ILSTYNAP---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------QI KKE------------------------------------KDKGK---------------- ---REK-------------------DEKERAK---------------------------- ---------------------EKER-----------------KEKDKKDRGKDR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------EREKDRVREQEKVKTEGG--------------------- ------------------------------------------------------------ -----KEVCTTTQTPPQIKKKED------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTREGGKTT-QTNPPAQRDEKWA-KEW DSK-TQ-PHVKREKEHDKDRGGTQ-A--------------------------AAHPRPDR EEARDSCTHKHK-SSHGKKEK----------------------------SGYREGKD--- -----------------------SNTSSTQAVLAKS------------------------ ---------------------------GR-EDGK--THKPANIQMKKEVKKDKD------ -----------------VSSKEERKKPASGPA--QPEHK----Q---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTLVTFDLFK----------------------- -------------------------------------------------P-MEAHQTLAL SFT----------------------D-SRP-KS------HH------------------- ------------------------------------------------------------ --HSDSRGS--------------------------------------------------- -----------------------------------SSK--------------PAS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ---RTVA-----------------PC-----------------KGTKV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------S-------------VQGKPAS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -ALQDTG----------------------------------------------------- --------------------------------PQQH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------LLKQ------------------------------ ----------------------------------P----------------------LKT HT-------P-------------------------------------------------- -------------------------QTQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSATEP00000032245 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLIAKRPPE-SRPPSSSD----------------IY--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRKLNGE---------------------------------- --------------------------------------LCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TAAA--------VPA------ -------------------------------------------------APARK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPHKV----------------------KKAKEKRHKE----K------------- -----EKS---------------------------------------------------- ----------------------------------SEAQRSSAAAAAVEKLSPASCH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDVK----------------------------------------ML----- ------------------------------------------------QR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---HRV------------------------------- ------------------K-EKDR----EKKKE----------------------KNK-E -WRNHK-LPPVHDISRENGDVVSPQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-SKVKRNAGLEED-LLKKLKKKKKKKHKDGERVKEKHS----------------- -------------R----PKMYHRSCQTVCSGVS-------------------------- ------------------------------LALPE------------------------- ---------------------------------------FLSQINGNN------------ --------------------------------------------SIN-SS-SLLHSA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------P-QH--HQDPSV TA---------------------------------------------------------- --------------------------------ASISSMVRDRLGYSSPLR---------- -------------------------CT--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EPGLPGLEFGCLIHIEQQANGGASVAHAYSEQLSVLSPAEMQRFADEFVTLSFSED-E AQAACFVMGIIHGAASYLPDFLDYFSSKFPNAPVKMEVLGKKDIETTTMANFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFISMLEESPFLERTLPWGTFSSLRLQSHTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHNDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHP-------------------QEE----------------E--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- --------------KE----------------------------------------E--- -EKEEEK--------CA----------QEDTVY--------------IKE---------- ------------------------------------------------------------ ------------------------------------------------------EEE--- -----------------DE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----EVEGKEHD----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---PAVLTVTKLEDG---GTEGRERLPSQTLTQIFKEEKKEGEI---------------- ------------------------------------------------------------ -----------------------------KESSMTQSLPLVKKDRHEGVPS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------HTLIEPKAK------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EKEEDKA GSDRGADTCHTLQKSHGEGGVDSALLKSLQPIRKESDVEEERHQRTVLSGQGLKEKTKES ITSSYNTT---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------QI KKE------------------------------------KDKTK---------------- ---REK-------------------DDKERP----------------------------- ----------------------KEKKDKDRSKE---------KERDKKDRGKDR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DREKDRMREQEKVKAEGA--------------------- ------------------------------------------------------------ -----REDTVSTQPLSLMRKKED------------------------------DE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTREGSKAS-QTSLPAQRDEKWA-KEW DSK-TQ-PHAKRERELDKDRGGTQ-T--------------------------ASHLQLDK EDTRDALSHKHK-PLHGKKEK----------------------------SGHREGKE--- -----------------------SIAASTQGVQAKS------------------------ ---------------------------GR-DDGKTGTPRPANIQVKKEGRKDKD------ -----------------INSKEERKKPVSGPA--PPEHK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTLITFDLFK----------------------- -------------------------------------------------P-MEFHQTLPL SFT----------------------D-SRP-KT------HH------------------- ------------------------------------------------------------ --HSDSRGS--------------------------------------------------- -----------------------------------TSK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ---RTHV-----------------SS-----------------KGPKV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------S-------------VQGKPAA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -PLQDT------------------------------------------------------ ----------------------------------QH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SLKQ------------------------------ ----------------------------------P----------------------LKT HT-------P-------------------------------------------------- -------------------------QTQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSSMAP00000009539 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLIAKRPPE-SRPQSSSD----------------IY--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRKVNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHSA-------AAAAA--------APA------ -------------------------------------------------TPARK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPLKM----------------------KKAKEKRHRE----K------------- -----EKG---------------------------------------------------- ----------------------------------GEAQRSS--PAAVERLSPASCR---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKSENGDVK----------------------------------------LL----- ------------------------------------------------QR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---PRV------------------------------- ------------------K-EKDR----EKK------------------------KSR-D -WKDHS-LPPVHDIARENGEATPPQR---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-PKEKLKAGSEEDLLLKKLKKKKKKKHKDGERVKERYS----------------- -------------R----PKMYHRSCQTVCSGVS-------------------------- ------------------------------LALPE------------------------- ---------------------------------------FLSRING----------KSSS SSSSSSNDGGGS---LLHATTTSQH----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------QH--HEDPPA TAT--------------------------------------------------------- -----------------------------ATSASISSMVRDRLGYSSPLH---------- -------------------------CT--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --APGLSGLEFGRLIHIEQQANGGASVAHAYSEQLSGLSPAEMQRFAQEFVTLSFSEE-D GQAASFVMGIIHGAASYLPDFLDYFSYKFPNAPVKMEVLGKKDIETTTMANFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFINMLEESPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPLADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDFPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------HEE----------------K--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE V----------------------------------------------------------- --------------KE----------------------------------------E--- -------------------------------------KCERTEVTLHITE---------- ------------------------------------------------------------ ------------------------------------------------------EEE--- -----------------DE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----DMEGKECD----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------PAVQRAMKMEREEIEGGEGPPSQIP-TQIFKEEEQES RAETKELSTTQSLPFVKKERDEGVLTHTLMEPKAE------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --DDEKGESK-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------EGQV------------------------------------ ---RGADTCQTLQKGHEEGGVDSSSLKSLQQIRKVNNVEEERQQKTTLSGQGLKERPKDS ITTTYNTP---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------PI KKD------------------------------------RDKGK---------------- ---REK-------------------DEKDRPK---------------------------- ---------------------DKERKDKERSKE---------KERDKKDRAKDK------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DRERDRMREHDKVKAEPG--------------------- ------------------------------------------------------------ -----KEGRTSMPLLPQIRKKED------------------------------DE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTREGSKAS-QTSLHAPKDEKWA-REW DGK-TQ-PHVKREKELDKDKAGAL-T--------------------------ASHLRPDR EEARDAFSLKHK-SSNGKKEK----------------------------SGLREGKE--- -----------------------SNTSS---MQAKS------------------------ ---------------------------GR-EDSKAGTPKTASIQVKKEGKKDKD------ -----------------ISSKDERKK-SSGPT--PPEHK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTLITFDLFK----------------------- -------------------------------------------------P-MEAHQTLAL SFT----------------------D-SRP-KS------HH------------------- ------------------------------------------------------------ --HSDSRGS--------------------------------------------------- -----------------------------------SSK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ---RTVV-----------------PS-----------------KGPRT------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------S-------------VQGKPAT-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -PLQDTR----------------------------------------------------- --------------------------------PPQH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------LLKQ------------------------------ ----------------------------------P----------------------LKT HP-------P-------------------------------------------------- -------------------------HTEK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------LLL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSLBEP00000011869 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AEAVDSMHFA------------------------------------- ANSKTNSPKPLIAKRPPE-CRPQSSSD----------------IY--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRKLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TAAA--------VPV------ -------------------------------------------------TPARK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPPKM----------------------KKAKEKRVKE----K------------- -----EKR---------------------------------------------------- ----------------------------------SEAQRSS--ALSVDRLSPASCH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDMK----------------------------------------ML----- ------------------------------------------------QR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---HRV------------------------------- ------------------K-EK------EKK------------------------KSK-E -WKNHR-TPPLHDIARENGEVFSPQE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-CQEKPKDGSEDDLLLKKLKKKKKKKHKDGERMKERHS----------------- -------------R----PKVYHRSCQTVCSGVS-------------------------- ------------------------------LGLPD------------------------- ---------------------------------------FLGRMNGNN------------ --------------------------------------------S----S-SLLHAAAA- ----------------PP------------------------------------------ ------------------------------------------------------------ ----------------------------------------------PPPPQHQQQQDL-- -A---------------------------------------------------------- -----------------------------ATSASITSIVRDRLCYSSPLH---------- -------------------------CV--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EPGLSGLEFGRLIHIEQQANGGASVAHAYTDQLSCLSPAEMQRFAQEFVTLSFSED-N AQAACFVMGIIHGAASYLPDFLDYFSYKFPNAPVKMEVLGKKDIETTTMVNFYSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFINMLEDSPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDAPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLQQYHQ-------------------HEE----------------E--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- ------------------------------------------------------------ -----------------------------------KDQCAPREEPLHIKE---------- ------------------------------------------------------------ ------------------------------------------------------EEE--- -----------------EEEEEEEDDDDDDKELEEVACDPVV------------------ ------------------------------------------------------------ ---------------DTVTK---------------------KEEMYAEERERAHTLAFTK EEQENAE----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---P-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KEVSTTQSLPSIKQESDEDVVTRTLTEPKAE------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EDENGESKGGGDEGAET----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------LQE--------------------------------------- ----------------EEAGVDSATLKTLQ-VRKENDLEEERQLKTTTPGQGLKEKTKDN IASTYNTH---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------QI KKE------------------------------------KDKVK---------------- ---RDK-------------------DEKERV----------------------------- ----------------------KEKKDKERSKE---------KDRDKKDKGKDR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------DKVREQERFKTEGGAS-----TQPV---------- -------------QP--------------------------------------------- ----SR-------------KKEE------------------------------DE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTKEGGKAS-QTSLHAHRDEKWASKEW 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------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDVK----------------------------------------MP----- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---PHV------------------------------- ------------------K-EKDR----QRKKE----------------------KKK-E -WKNNSLLPPVHDITRENGEVLFPQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D--KEKLKAVSEEDLLLKKLKKKKKKKHKDGERFRERHS----------------- -------------R----PKMYHRSCQTVCSGVS-------------------------- ------------------------------LGLPE------------------------- ---------------------------------------LFSRINGNN------------ --------------------------------------------S----G-SLI------ ----GSSSVSH------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------QH--LQDPAV TA---------------------------------------------------------- -----------------------------STSSSIHSMVRDQLEYSSPLH---------- -------------------------CT--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TPVLPELEFGRLIHVEQQANGGASVVHAYYDQLACLSPSELERFAEEFVSLSFSED-E SQAACFVMGIIHGAASYLPDFLDYFSYNFPNAPVKMEVLGKKDIETTTMANFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFIRMLEESPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKLYHQ-------------------HEN----------------KEE------- ------------------------------------------------------------ ----EE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- --------------EE----------------------------------------A--- -RREEDK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------SSPGVLTHDIKDEEDEHEERVKIDLAVQTGIKLKEEDMEE----- KQELPLRNR----------------------------------------TQTFKEEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LED---------------RIESEEVSAANPPLSANNEICEVHYSTLTESKVEENEKEGS ERGVDAYQRLQKVPEGSTEDGPAF------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------KSLQYVRKENDVEEERQQKTPLSGPSLKEKAKDS STSPSNTQ---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------HI KKE--------------------------------------KGK---------------- ---REK-------------------DEKIRM----------------------------- ----------------------KEKKDKDRC-----------KDRDKRDRGK-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DGEKDRVR--EKVKAEGG--------------------- --KEDGTPMPQ------------------------------------------------- ----------------QTKKKED------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTRE--KTS-QTVPPVHKEDK-----W DLK-SQ-HHTKKEKEHDR-------------------------------GGLPPHSRLEK EEALDACTHKHK-SFQGKTEK----------------------------SGHREGKD--- -----------------------SS----AGMQAKP------------------------ ---------------------------AR-EDGK--THKPTNLQVKKEVKKEKD------ -----------------FNSKEEKKKAG--------EQK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTFVTFDLFE----------------------- -------------------------------------------------P-MDAHQTLAL SLT----------------------D-SRP-KP------HH------------------- ------------------------------------------------------------ --H-----S--------------------------------------------------- -----------------------------------SSK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----LV-----------------TS-----------------KGPKI------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------S-------------VPGKPST-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -ALQDTG----------------------------------------------------- --------------------------------P-QH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SIKP------------------------------ ----------------------------------P----------------------QKT HT-------Q-------------------------------------------------- -------------------------QRQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSORLP00000013231 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLTAKRPPE-SRPQSSSD----------------IF--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKIRVEEK-GLKHKKLNGD---------------------------------- --------------------------------------VCAGEKHNGN------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TAAG--------MPV------ -------------------------------------------------TPVRN------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPPKV----------------------KKAKEKRPKE----K------------- -----EKS---------------------------------------------------- ----------------------------------GDARRSS--TAAVEKVSPASCH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDVK----------------------------------------MP----- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---PHV------------------------------- ------------------K-EKDR----QRKKE----------------------KKN-E -WKNNSLLPPVHDITRENGEVLFPQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D--KEKLKAVSEEDLLLKKLKKKKKKKHKDGERFRERHS----------------- -------------R----PKMYHRSCQTVCSGVS-------------------------- ------------------------------LGLPE------------------------- ---------------------------------------LFSRINGNN------------ --------------------------------------------S----G-SLI------ ----GSSSVSH------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------QH--LQDPAV TA---------------------------------------------------------- -----------------------------STSSSIHSMVRDQLEYSSPLH---------- -------------------------CT--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TAVLPELEFGRLIHVEQQANGGASVVHAYYDQLACLSPSELERFAEEFVSLSFSED-E SQAACFVMGIIHGAASYLPDFLDYFSYNFPNAPVKMEVLGKKDIETTTMANFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFIRMLEESPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKLYHQ-------------------HEN----------------K--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- --------------EE----------------------------------------A--- -RREEDK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------SSPGVLTHNIKDEEDEHEERVKIDLAVQTGIKLKEEDLEE----- KQELPLKNR----------------------------------------TQTFKEEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LED---------------RIESEEVSAGNPPLSANNERCEVHYSTLTVSKVEENEKEGS ERGVDAYQRLQKVPEGSTEDGPAF------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------KSLQYVRKENDVEEERQQKTPLSGPSLKEKAKDS STSPSNTP---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------HI KKE--------------------------------------KGK---------------- ---REK-------------------DEKIRM----------------------------- ----------------------KEKKDKDRC-----------KDRDKRDRGK-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DREKDRVR--EKVKAEGG--------------------- --KEDGTPMPQ------------------------------------------------- ----------------QTKKKED------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTRE--KTS-QTVPPVHKEDK-----W DLK-SQ-HHTKKEKDHDR-------------------------------GGLPPHSRLEK EEALDACTHKHK-SFQGKTEK----------------------------SGHREGKD--- -----------------------SS----VGMQAKP------------------------ ---------------------------AR-EDGK--THKPTNLQVKKEVKKEKD------ -----------------FNSKEEKKKAG--------EQK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTFVTFDLFE----------------------- -------------------------------------------------P-MDAHQTLAL SLT----------------------D-SRP-KP------HH------------------- ------------------------------------------------------------ --H-----S--------------------------------------------------- -----------------------------------SSK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----LL-----------------TS-----------------KGPKT------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------S-------------VPGKPST-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -ALQDTG----------------------------------------------------- --------------------------------P-QH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SIKP------------------------------ ----------------------------------P----------------------QKT HT-------Q-------------------------------------------------- -------------------------QTQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSORLP00015029744 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSLKPLTAKRPPE-SRPQSSSD----------------IF--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKIRVEEK-GLKHKKLNGD---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TAAG--------MPV------ -------------------------------------------------TPVRN------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPPKV----------------------KKAKEKRPKE----K------------- -----EKS---------------------------------------------------- ----------------------------------GDARRSS--TAAVEKVSPASCH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDVK----------------------------------------MP----- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---PHV------------------------------- ------------------K-EKDR----QRKKE----------------------KKK-E -WKNNSLLPPVHDITRENGEVLFPQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D--KEKLKAVSEEDLLLKKLKKKKKKKHKDGERFRERHS----------------- -------------Q----PKMYHRSCQTVCSGVS-------------------------- ------------------------------LGLPE------------------------- ---------------------------------------LFSRINGNN------------ --------------------------------------------S----G-SLI------ ----GSSSVSH------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------QH--LQDPAV TA---------------------------------------------------------- -----------------------------STSSSIHSMVRDQLEYSSPLH---------- -------------------------CT--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TPVLPELEFGRLIHVEQQANGGASVVHAYYDQLACLSPSELERFAEEFVSLSFSED-E SQAACFVMGIIHGAASYLPDFLDYFSYNFPNAPVKMEVLGKKDIETTTMANFHSQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFIRMLEESPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKLYHQ-------------------HEN----------------K--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- --------------EE----------------------------------------A--- -RREEDK----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------SSPGVLTHDIKDEEDEHEERVKIDLAVQTGIKLKEEDLEE----- KQELPLKNR----------------------------------------TQTFKEEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LEN---------------RIESEEVSAANPSLSANNEICEVHYSTLTESKVEENEKEGS ERGVDAYQRLPKVPEGSTEDGPAF------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------KSLQYVRKENDVEEERQQKTPLSGPSLKEKAKDS STSPSNMP---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------HI KKE--------------------------------------KGK---------------- ---REK-------------------DEKIRM----------------------------- ----------------------KEKKDKDRC-----------KDRDKRDRAK-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DREKDRVR--EKVKAEGG--------------------- --KEDSTPMPQ------------------------------------------------- ----------------Q--KKED------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTRE--KTS-QTVPPVHKEDK-----W DLK-SQ-HHTKKEKDHDR-------------------------------GALPPHSRLEK ED----CTHKHK-SFQGKTEK----------------------------SGHREGKD--- -----------------------SS----AGMQAKP------------------------ ---------------------------AR-EDGK--THKPTNLQVKKEVKKEKD------ -----------------FNSKEEKKKAG--------EQK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTFVTFDLFE----------------------- -------------------------------------------------P-MDAHQTLAL SLT----------------------D-SRP-KP------HH------------------- ------------------------------------------------------------ --H-----S--------------------------------------------------- -----------------------------------SSK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----LV-----------------TS-----------------KGPKI------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------S-------------VPGKPST-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -ALQDTG----------------------------------------------------- --------------------------------P-QH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SIKP------------------------------ ----------------------------------P----------------------QKT HT-------Q-------------------------------------------------- -------------------------QMQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPFOP00000017383 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLLAKRPPE-SRPQSSSD----------------IF--PPT---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRKLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TASA--------MPT------ -------------------------------------------------TPVRK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPPKV----------------------KKAKEKRHKE----K------------- -----ERS---------------------------------------------------- ----------------------------------SEAPRSS--AAAVERVSPASCN---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDVK----------------------------------------TL----- ------------------------------------------------QR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---HSV------------------------------- ------------------K-EKDR----QKKKE----------------------KNK-E -WNKHK-LPPVHDIVRENGEVMSPQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-SKEVLSVGSEEELLLKKLKKKKKKKHKDSEWVKERHS----------------- -------------R----PKMYHRSCQTVCSGVT-------------------------- ------------------------------LGLPE------------------------- ---------------------------------------FLGRINGDS------------ --------------------------------------------S---SS-GLIHST--- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------TIP-QH--FQDPAA AAAA-------------------------------------------------------- ----------------------------AASPPTMSSIVRDRLSYG-------------- -------------------------CT--------------------------------- -------------------A---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TAGLPGLEFSHLIHIEQQANGGASVVHAYTEELSCLSPAEMQRFAEEFVSLSFSED-G AQGARFVMGIIHGAASYLPDFLDYFSYKFPNATVKMEVLGKKDIETTTMATFHSQVKRTY SRGTYRAGAMRQVSLVGAVDEEVGDYFPEFLSMLEESPFLVRTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------QEE----------------R--------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GQEEMKELLGTQPLPLVQNESEEV VFSPTSMEIKVEELQEDRKGGAETNQRLAGREDSGQDAAFLKAS---------------- ------------------------------------------------------------ -----------------------------HQVKKESDVEEERQPKAA-----LPDKTKDD TTSAPSTP---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------QI KKE------------------------------------KDKGK---------------- ---RER-------------------DERERT----------------------------- ----------------------KEKKEKDRS-----------KDKEKKDRGKDR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ER--------EKVKTEGG--------------------- --RDGGALI--------------------------------------------------- --------------LTQIKKKED------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTKEGSRGC-PTAPAAQRDEKWA-KEA DSK-TQ-TNLKRDKEHDKDRG-------------------------------APPSRPDR EDGRDGGSHKNK-STHGKKEK----------------------------SGHKEGKD--- ------------------------------------------------------------ -------------------TSVSSAKPGR-EDGK--THKHPQLQAKKDGKKEKDGGRE-- ------------EIRKK------------------PEHK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ARTLFTFDLFK----------------------- -------------------------------------------------P-LEAHQPLTL SLS----------------------D-SRP-KP--------------------------- ------------------------------------------------------------ --HTDPRGP--------------------------------------------------- -----------------------------------SSK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DA-------------------------------- ------------------------------------------------------------ ---RTLV-----------------PS-----------------KGPKV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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QT-------P-------------------------------------------------- -------------------------QTQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FSI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPLAP00000004320 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLLAKRPPE-SRPQSSSD----------------IF--PPT---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRKLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TASA--------MPT------ -------------------------------------------------TPVRK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPPKV----------------------KKAKEKRHKE----K------------- -----ERS---------------------------------------------------- ----------------------------------SEAPRSS--AAAVERVSPASCH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDVK----------------------------------------TL----- ------------------------------------------------QR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---HSV------------------------------- ------------------K-EKDR----QKKKE----------------------KNK-E -WNKHK-LPPVHDIVRENGEVMSPQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-SKEVLSVGSEEELLLKKLKKKKKKKHKDSEWVKERHS----------------- -------------R----PKMYHRSCQTVCSGVT-------------------------- ------------------------------LGLPE------------------------- ---------------------------------------FLGRINGDS------------ --------------------------------------------S---SS-GLIHST--- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------TIP-QH--FQDPAA AAAA-------------------------------------------------------- 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------------------------------------------------------------ ------------------------------------GQEEMKELLGTQPLPLVQNESEEV VFSPTSMEIKVEELQEDRKGGAETNQRLAGQEDAGQDAAFLKAS---------------- ------------------------------------------------------------ -----------------------------HQVKKESDVEEERQPKAA-----LPDKTKDD TTSAPSTP---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------QI KKE------------------------------------KDKGK---------------- ---RER-------------------DERERT----------------------------- ----------------------KEKKEKDRS-----------KDKEKKDRGKDR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ER--------EKVKTEGG--------------------- --RDGGALI--------------------------------------------------- --------------LTQIKKKED------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTKEGSRGC-PTAPAAQRDEKWA-KEA DSK-TQ-TNFKRDKEHDKDRG-------------------------------APPSRPDR EDGRDGGSHKNK-STHGKKEK----------------------------SGHKEGKD--- ------------------------------------------------------------ -------------------TSVSSAKPGR-EDGK--THKHPQLQAKKDGKKEKDGGRE-- ------------EIRKK------------------PEHK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ARTLFTFDLFK----------------------- -------------------------------------------------P-LEAHQPLAL SLS----------------------D-SRP-K---------------------------- ------------------------------------------------------------ --------P--------------------------------------------------- -----------------------------------SSK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DA-------------------------------- ------------------------------------------------------------ ---RTLV-----------------PS-----------------KGPKV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------S-------------LQGKPAAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -GLQD------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SLKQ------------------------------ ----------------------------------P----------------------LRT QT-------P-------------------------------------------------- -------------------------QTQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FSI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPMEP00000018484 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLLAKRPPE-SRPQSSSD----------------IF--PPT---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRKLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TASA--------MPT------ -------------------------------------------------TPVRK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPPKV----------------------KKAKEKRHKE----K------------- -----ERS---------------------------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-SKEVLSVGSEEELLLKKLKKKKKKKHKDSEWVKERHS----------------- -------------R----PKMYHRSCQTVCSGVT-------------------------- ------------------------------LGLPE------------------------- ---------------------------------------FLGRINGDS------------ --------------------------------------------S---SS-GLIHST--- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------TIP-QH--FQDPAA AAAS-------------------------------------------------------- --------------------------------PTMSSMVRDRLSYG-------------- -------------------------CT--------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTKEGSRGC-PTAPATQRDEKWA-KEA DSK-TQ-TNLKRDKEHDKDRG-------------------------------APPSRPDR EDGRDGGSHKHK-STHGKKEK----------------------------SGHKEGKD--- ------------------------------------------------------------ -------------------TSVSSAKPGR-EDGK--THKHPQLQAKKDGKKEKDGGRE-- ------------EIRKK------------------PEHK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ARTLFTFDLFK----------------------- -------------------------------------------------P-LEAHQPLTL SLS----------------------D-SRP-KP--------------------------- ------------------------------------------------------------ --HTDPRGP--------------------------------------------------- -----------------------------------SSK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DA-------------------------------- ------------------------------------------------------------ ---RTLV-----------------PS-----------------KGPKV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------S-------------LQGKP-AVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -GLQD------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SLKQ------------------------------ ----------------------------------P----------------------LRT QT-------P-------------------------------------------------- -------------------------QTQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FSI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSXMAP00000009142 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLLAKRPPE-SRPQSSSD----------------IF--PPT---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRKLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TASA--------MPT------ -------------------------------------------------TPVRK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPPKV----------------------KKAKEKRHKE----K------------- -----ERS---------------------------------------------------- ----------------------------------SEAPRSS--AASVERVSPASCH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDVK----------------------------------------TL----- ------------------------------------------------QR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---HSG------------------------------- ------------------K-EKDR----QKKKE----------------------KNK-E -WKKHK-LPPVHDIVRENGEVMSPQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-SKEVLSVGSEEELLLKKLKKKKKKKHKDSEWVKERHS----------------- -------------R----PKMYHRSCQTVCSGVT-------------------------- ------------------------------LGLPE------------------------- ---------------------------------------FLGRINGDS------------ --------------------------------------------S---SS-GLIHNT--- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------TIP-QH--FQDPAA GASA-------------------------------------------------------- ---------------------------------TMSSMVRDRLSYG-------------- -------------------------CT--------------------------------- -------------------A---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TAGLPGLEFSHLIHIEQQANGGASVVHAYTEELSCLSPAEMQRFAEEFVSLSFSED-G AQAARFVMGIIHGAASYLPDFLDYFSYKFPNATVKMEVLGKKDIETTTMATFHSQVKRTY SRGTYRAGAMRQVSLVGAVDEEVGDYFPEFLSMLEESPFLVRTLPWGTFSSLRLQSPTDS DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------QEE----------------R--------- ------------------------------------------------------------ -----K------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- --------------EE----------------------------------------E--- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GQEEMKVLPGTQFLPSVQNESEEV VFSPMPMEIKVEELEEDRKGGAETNQRLPGQEDAGQDAASLKSS---------------- ------------------------------------------------------------ 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------------------------------------------------------------ ---------------------------------RTKEGNQGC-PTAPSAQRDDKWA-KEA DSK-TQ-THFKRDKEHDKDRG-------------------------------APPSRPDR EDGRDGGSHKHK-STHGKKEK----------------------------SGHKEGKD--- ------------------------------------------------------------ -------------------TS-ASGKPGR-EDRK--THKHTQLQVKKDCKKEKDGGRE-- ------------EIRKK------------------PEHK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ARTLFTFDLFK----------------------- -------------------------------------------------P-MEAHQPLAL SLS----------------------D-SRP-KP--------------------------- ------------------------------------------------------------ --HTDPRGS--------------------------------------------------- -----------------------------------SSK--------------LGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DA-------------------------------- ------------------------------------------------------------ ---RTLV-----------------PS-----------------KGPKV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------S-------------LQGKPATSA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -GLQD------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SLKQ------------------------------ ----------------------------------P----------------------LRT QT-------P-------------------------------------------------- -------------------------QTQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSXCOP00000027370 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MHFA------------------------------------- ANSKTNSPKPLLAKRPPE-SRPQSSSD----------------IF--PPT---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRKLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TASA--------MPT------ -------------------------------------------------TP--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------EELLLKKLKKKKKKKHKDSEWVKERHS----------------- -------------R----PKMYHRSCQTVCSGVT-------------------------- ------------------------------LGLPE------------------------- ---------------------------------------FLGRINGDS------------ --------------------------------------------S---SS-GLIHST--- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------TIP-QH--FQDPAA GASA-------------------------------------------------------- ---------------------------------TMSSMVRDRLSYG-------------- -------------------------CT--------------------------------- -------------------A---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TAGLSGLEFSHLIHIEQQANGGASVVHAYTEELSCLSPAEMQRFAEEFVSLSFSED-G AQAARFVMGIIHGAASYLPDFLDYFSYKFPNATVKMEVLGKKDIETTTMATFHSQVKRTY SRGTYRAGAMRQVSLVGAVDEEVGDYFPEFLSMLEESPFLVRTLPWGTFSSLRLQSPTDS DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------QEE----------------R--------- ------------------------------------------------------------ -----K------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- --------------EE----------------------------------------E--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------RFSLSEARHRIKQEEDAEEEGNK------------------ ------------------------------------------------------------ -----------CDFAV-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------QTVRKVEDEDIEGREEPPSQTL-THHFKKEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GQEEMKVLPGTQFLPSVQNESEEV VFSPMPMEIKVEELEEDRKGGAETNQRLPGQEDAGQDAASLKSS---------------- ------------------------------------------------------------ -----------------------------QQIKKESDVEEERQPKPA-----LPEKTKDD TTSAYSTP---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------QI KKE------------------------------------KDKGK---------------- ---RER-------------------DERERT----------------------------- ----------------------KEKKEKDRS-----------KDKEKKDRGKDR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ER--------EKVKTEGG--------------------- --RDGGTLI--------------------------------------------------- --------------LTQIKKKED------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RTKEGNQGC-PTAPSAQRDEKWA-KEA DSK-TQ-THFKRDKEHDKDRG-------------------------------APPSQPDR EDGRDGGSHKHK-STHGKKEK----------------------------SGHKEGKD--- ------------------------------------------------------------ -------------------TS-VLGKPGR-EDGK--THKHTQLQVKKDGKKEKDGGRE-- ------------EIRKK------------------PEHK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ARTLFTFDLFK----------------------- -------------------------------------------------P-MEAHQPLAL SLS----------------------D-SRP-KP--------------------------- ------------------------------------------------------------ --HTDPRGS--------------------------------------------------- -----------------------------------SSK--------------LGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DA-------------------------------- ------------------------------------------------------------ ---RTLV-----------------PS-----------------KGPKV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------S-------------LQGKPATSA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -GLQD------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SLKQ------------------------------ ----------------------------------P----------------------LRT QT-------P-------------------------------------------------- -------------------------QTQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FSI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSGAFP00000009403 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLLAKRPPE-SRPQSSSD----------------IF--PPT---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRKLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TASA--------MPT------ -------------------------------------------------TPVRK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPPKV----------------------KKAKEKRHKG----K------------- -----ERS---------------------------------------------------- ----------------------------------SEAPRSS--AASVERVSPASCH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDVK----------------------------------------TL----- ------------------------------------------------QR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---HSV------------------------------- ------------------K-EKDR----QKKKE----------------------KNK-E -WKKHK-LPPVHDIVRENGEVMSPQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-CKEVLSVGSEEELLLKKLKKKKKKKHKDGEWVKERHS----------------- -------------R----PKMYHRSCQTVCSGVT-------------------------- ------------------------------LGLPE------------------------- ---------------------------------------FLGRINGDS------------ --------------------------------------------S---SS-GLIHST--- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------TIP-QH--FQDSAA GVTG-------------------------------------------------------- ---------------------------------TMSSMVRDRFSYG-------------- -------------------------CT--------------------------------- -------------------A---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TAGLPGLEFSHLIHIEQQANGGASVVHAYTEELSCLSPAEMQRFAEEFVSLSFSED-G AQAARFVMGIIHGAASYLPDFLDYFSYKFPNATVKMEVLGKKDIETTTMATFHSQVKRTY SRGTYRAGAMRQVSLVGAVDEEVGDYFPEFLSMLEESPFLMRTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTPARITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLRQYHQ-------------------QEE----------------R--------- ------------------------------------------------------------ -----K------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE A----------------------------------------------------------- --------------EE----------------------------------------Q--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------KFSLSEALHRIKQEEDVEEEGNK------------------ ------------------------------------------------------------ -----------CDFAV-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------QTVRKVEDEDIEGREEPPSQTL-THHFKEEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GQEEMKELPGTQFLPSVQNESEEV VFSPTAMEIKVEELQEDRKGGAETNQRPPGQEDAGQDAASLKSS---------------- ------------------------------------------------------------ -----------------------------QQIKKESDVEEERQPKPA-----LPDKTKDD TTSAYSTP---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------QI KKE------------------------------------KDKGK---------------- ---RER-------------------DERERI----------------------------- ----------------------KEKKEKDRS-----------KDKDKKDRGKDR------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ER--------EKVKSEGG--------------------- --RDGGTLI--------------------------------------------------- --------------LTQIKKKED------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RMKEGNQGC-LTAPSAQRDEKWA-KEA DPK-IQ-THFKRDKEHDKDRG-------------------------------APPSRPDR ED----GSHKHK-STHGKKEK----------------------------SGHKEGKD--- ------------------------------------------------------------ -------------------TS-ASGKPGR-EDGK--THKLTQLQVKKDSKKEKDGGRE-- ------------EIRKK------------------PEHK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ARALFTFDLFK----------------------- -------------------------------------------------P-MEAHQPLAL SLS----------------------D-SRP-KP--------------------------- ------------------------------------------------------------ --HTDPRGS--------------------------------------------------- -----------------------------------SSK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DA-------------------------------- ------------------------------------------------------------ ---RTLV-----------------PS-----------------KGSKA------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------S-------------LQGKPATSA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -GLQD------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SLKQ------------------------------ ----------------------------------P----------------------LRT QT-------P-------------------------------------------------- -------------------------QTQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FSI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCVAP00000005913 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLLAKRPPE-SRPQSSSD----------------IF--PPT---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRKLNGE---------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TASA--------MPT------ -------------------------------------------------TPVRK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPPKV----------------------KKAKEKRHKE----K------------- -----ERS---------------------------------------------------- ----------------------------------SEAPRSS--AAAVERVSPASCH---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDVK----------------------------------------TL----- ------------------------------------------------QR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---HDV------------------------------- ------------------K-EKDR----QKKKE----------------------KNK-E -WKKHK-LPPAHDIVRENGEAMTHQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-SKEILSVGSEEELLLKKLKKKKKKKHKESEWVKERRS----------------- -------------R----PKMYHRSCQTVCTGMP-------------------------- ------------------------------LGLPE------------------------- 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DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTPSRITKDVVCFHAGDFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------QEE----------------K--------- ------------------------------------------------------------ -----K------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- --------------RED------------------LDE-----------------GE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------TCSFSEALNRIKQEEDVEEEGNK------------------ ------------------------------------------------------------ -----------CDFAV-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------QTVTKMEEEDMEGQQEPTSHTL-THNFKEEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --QDE------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LDERKELV G---------------------------------------TQSPTSVQNESEEAVF---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SPTAIEIKAEVIHEERKRGSETHQRL DGQEEAGQDATSLKFLQQIRKDSDVEEEQHQKKDQT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------DKTKDD TTSICNTP---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------QI KKE------------------------------------KDKGK---------------- ---RER-------------------DERERT----------------------------- 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------------EIRKK------------------PEQK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ARTLFTFDLFK----------------------- -------------------------------------------------P-MEAHQTLAL SLS----------------------D-SRP-KP------QH------------------- ------------------------------------------------------------ --HTDPRGS--------------------------------------------------- -----------------------------------SSK--------------SGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ---RTVV-----------------ST-----------------KGPKV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------S-------------LQGKPSMAS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -TLQD------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SIKQ------------------------------ ----------------------------------P----------------------LRT QT-------P-------------------------------------------------- -------------------------QTQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLI- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSKMAP00000008184 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVDSMHFA------------------------------------- ANSKTNSPKPLLAKRPPE-SRPQSSSD----------------IF--PPP---------- --------------------------------------------------L--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEK-GLKHRKLNGE---------------------------------- --------------------------------------ACAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHP---------AASV--------SPA------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---HSV------------------------------- ------------------K-EKDK----QKKKE----------------------KNK-E -WKNHQ-MPPVHDIVRENGDVTSPQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-SKEKLKAGSEEDLLLKKLKKKKKKKHKDGERAKERHS----------------- -------------R----PKMYHRSCQTVCSGLA-------------------------- ------------------------------LGLPD------------------------- ---------------------------------------FLSQINGDN------------ ------------------------------------------------GS---------- 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LAWHIRLKLYHQ-------------------HEE----------------E--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------VNEE-------------------------------------------- ------------------------------------DMCSPRDTALNIKK---------- ------------------------------------------------------------ ------------------------------------------------------EED--- -----------------EQEE--------------------------------------- ------------------------------------------------------------ ---------------------------------------GNK------------------ ------------------------------------------------------------ -----------CDLALQTVMKVE------------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ---------------------DRERERVKE----------GSCLLPG------------- ------------------------------------------------------------ ------------------KKKED------------------------------ED----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RPREGTKNS-QTTVSTLRDEK-----S DSK-TQ-PSVKREKEHNKEWGGSQ-A--------------------------APPSRSDK EEARDSWTHKHK-SSLGKKEK----------------------------SVHREGKDG-- ---------------------G-------------------------------------- -------G-----------ASSSQGRPGR-EDGK--THKHPSLNVKKDCKKEKD------ -----------------VSSKEEKKKAVCAPS--QTEHK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ARTLVTFDLFK----------------------- -------------------------------------------------P-MEASQTLAF SLS----------------------D-TRP-KP--------------------------- ------------------------------------------------------------ --HSDSRGS--------------------------------------------------- -----------------------------------SSK--------------SGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ---RTMA-----------------PS-----------------KGLKV------------ ------------------------------------------------------------ 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VQPRKE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- --------------EE----------------------------------------E--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------DDDDDDGE---------------------------- ------------------------------------------------------------ ------------------------------------------------------SLSLT- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KE----------S-------------VQGK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --LQD------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AIKQ------------------------------ ----------------------------------P----------------------LKT 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------------------------------------------------------------ -------KKVRVEEK-GLKHRRVNGE---------------------------------- --------------------------------------ACAEENH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AEA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS---------TAAA--------VPT------ -------------------------------------------------TPARK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ----------------------------------------------------------DE QE---------------------------------------------------------- ------------LKEEKCARTEITLCIKEEDKEAGV--------------------E--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------KCEPSVQT---- ------------------------------------------------------------ ------------------------------------------------------------ KAEP--------------------------------EE---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GRVTTRITEQEEKEHKAEARELAMTQSVLF VRKETDGGALPHTLIEPKVEQVEKESALGVESTRADACPIQMKILEEGVADGLPLKPLHQ 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--------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------C -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SHS----------AAS--------LPG------ -------------------------------------------------TPARK------ -----------------------IFKISNFL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ASPHKV----------------------KKSKEKRHKE----K------------- -----EKS---------------------------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------EED-LLKKLKKKKKKKHKDGERPKDRHN----------------- -------------R----PKMYHRSCQTVCSGVS-------------------------- ------------------------------LSLPD------------------------- ---------------------------------------FLSKMNGNS------------ --------------------------------------------S---SS-TFLTST--- ---------------SPPAL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------HQD--- -----TNCSSVPSP---------------------------------------------- -------------------------AV-------------DRPGYCSPLH---------- -------------------------CT--------------------------------- 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KE---------------------------------------------------------- ------------DKEE-------------------------------------------- -------------------------------------KCEPRE----------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LSQIKEEYEEEQPVSDEKE GLTTVHMEMTEEQPLLSQVSELVIKKEEKEADIMDPSTITPVVTVKEEINKDIVQPTVTE PKTEPEEALYPTVHMD-------------------------------------------- ------------------------------------------------------------ -----------CD----------------------------------------------- -------KTGEVHNDV-------------------------------------------- ------------------------------------------------------------ ---P-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------P RESGKSYSSEKSSKE--------------------------------------------- -------VHIKREKEHDKERSSSQ------ML----------------------HSRPDR E---DAHGHKHK-FSHGKKEK----------------------------SAHRESKD--- -----------------------SSSTTPHSSQTKS------------------------ ---------------------------AR-EEGK-----------------------SST PKACSNQFKKEKEM-----SKDERKHPSSSSA--PSEHK----A---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTLVTFDLFK----------------------- -------------------------------------------------P-MAAHMS-AP SFT----------------------D-CRP-KS------HH------------------- ------------------------------------------------------------ --HSESRCT--------------------------------------------------- -----------------------------------LSK--------------PGS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ---RTVV-----------------AS-----------------KGPKV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KDS--------AS-------------VQGKPTV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -SIQDTR----------------------------------------------------- --------------------------------TSQH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SLKS------------------------------ ----------------------------------P----------------------LKT HP-------P-------------------------------------------------- ------------------------SHTQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSHCOP00000009143 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MHFA------------------------------------- ANSQTNSPQALLAKRPPE-SRPQSSSD----------------IH--PPP---------- --------------------------------------------------T--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKIRVEEK-RPKHRKVNGE---------------------------------- --------------------------------------VCTVEKH--N------------ ----------------GKPT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SSQEDLLLKKLKKKKKKKHKDGERAKERHG----------------- -------------R----PKMYHRSCQTVYSGVS-------------------------- ------------------------------LGLAE------------------------- ---------------------------------------FLSRINGNS----------G- --------GGG----------------------------------------GLLHST--- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------QHPDP-- ------------------------------------------------------------ --------------------------------ASIPAAVRERLGYISPLH---------- -------------------------CT--------------------------------- -------------------P---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TPSLPGLEFGHLIHVEMQANGGASVVRAYGEQLSALPPAEMQRFAQEFVTLSFSED-G AQAACFVMGIIHGAASYLPDFLDYFSYNFPNAPVKMEVLGKKDIETTTMANFHTQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFIRMLEDSPFLERTLPWGTFSSLRLQSPTES DDGPIMWVRPGEQMIPMADMPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GEDSDTPARITKDVVCFHAADFPDVVMRL QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVIHQFKTVSAVCS LAWHIRLKQYHQ-------------------HEA----------------V------G-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EE---------------------------------------LE--- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---RTK-------------------DERERTKEERTKEEKER------IKEE-------- -------------KERSKEEKERTKEDKDRSKEERKD---KSKPRDRKHKVKDK------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------EREK----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------VKTDIMPMARK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------KDKEPGGGGGAVSVLSLNSRP-- ------------------------------------------------------------ ------------------------------------------------------------ EEARDGC--KHK-SSQGKKEK----------------------------SGHR------- ---------------------------------------SDALTPKSDASAPKSDPKASP IKPAPL----------------------R-RDGK-------------------------- --------------------KEEPK-------------K----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTLITIDLFK----------------------- -------------------------------------------------P-MEAHQTVAL SF-----------------------------KT------HH------------------- ------------------------------------------------------------ --H--------------------------------------------------------- -------------------------------------Q--------------HGSARP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TDN-------------------------------- ------------------------------------------------------------ ---RTLV-----------------PF-----------------KGTKV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KS----------------------------------GPPLADPQT-------------- ---------QQQ----------------HS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ALKQ------------------------------ ----------------------------------T----------------------LKT H----------------------------------------------------------- ----------------------------K------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLI- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGD------------------------------------------------- --------------------------------------------------T--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------ACD---HTG------------------------------- ------------------K-DEER----EKKKE------------------SDKERDR-E -KKNHQ-VMVVNE--RENGEVKSPLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-STEKPKVNSEDELLLKKLKKKKKKKHKDCER--ERRS----------------- -------------R----PKMYHRSSQTVCSGVS-------------------------- ------------------------------VDLPD------------------------- ---------------------------------------LLN------------------ --------------------------TPDRSNYNTNNSFFHTFPS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------P-----HQDPSS TT------TTT------------------------------------------------- -----------------------------SVSISTASMVRERLGYGSPLH---------- -------------------------SA--------------------------------- -------------------Q---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --SQGMSGLEFGRLIHVEQQANGGASVAHAYCQQLACLSPAEMQRFAQEFVTLSFSED-Q ADAAHYVMGIIHGAASYLPDFLDYFSYKFPNAPVKMEVLGKKDIETTTMANFHTQVKRTY SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFINMLEESPFLERTLPWGTFSSLRLRSPTES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-RE-GDAPARVTKDVVCFHAGDFPEVVQRL QLDLYEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLRQYHL-------------------DQE----------------R--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EESCTSTRATSQVIEEE------------------------------------------- --------------EE----TE----------------------------------E--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SEEEWGKEEDTPIQPRTQVKTE--EEGGERTPVQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------PLVC------------------------------- ------------------------------------------------------------ -----------------------------------------------------KEED--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------DTEEKGGERGGCTPTLTLPLVKEEREEGNP LIETLLEVKERKEVDEHHKLEEMERKGARDVSTSTQMAPQVQMEGERDG----------- --ED-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MELSKASQQAGIKREEEERHYKTPPQVQKERERGKDGSTATQT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------P---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------QV K----------------------------------------KGKGKDLEKDGKEKEKEER VKDKEKVERMKEKEK----VERVKDKEKERV----------------------------- ----------------------KE-----------------EREKDKKERVKDK------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DRERER--------------------------------- -----------------------------------------------------------G KDESVMESTTQTQTSPPIRKKED------------------------------EE----- -------------------------------------RKHT-------HP---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SQHAQREEKGMREADTA------------------- ------------------------------------------------------------ -SK-TQ-PQIKKERDRDRGGSSTQ-T--------------------------QSHTRLER EEGRESSTHGHK-PSHGKKER----------------------------NGYREGKEGNP S------------------MHT-------------------------------------- ----------------------SHTKPGREEDGKAVTSRHTPSHVKKEAKRDRG------ -----------------VNHKEERKKPPPAPSCPPSDHK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTLVTFDLFK----------------------- -------------------------------------------------P-MEAFQAPPL SLA----------------------DKSLADKS------HH------------------- ------------------------------------------------------------ --HSECRGA--------------------------------------------------- -----------------------------------LSK--------------P------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ES-------------------------------- ------------------------------------------------------------ ---RTLA-----------------PS-----------------KGPKV------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD----------T-------------TQTKPAV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AESVGSMHFA------------------------------------- ANGKINPPKPLVPKIPPE-SRPQSSND----------------VF--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRIEEK-SLKQKKLNGDV--------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------Y -GS--PAKWSFG------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ----TKTENGDGK----------------------------------------ML----- -------------------------------------------------G---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---HTG------------------------------- ------------------K-DEER----EKKREK----------------DTDKERDR-E -KKNHP-GMVVNDVARENGEVKMPLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-STEKPKFNSEDQLLLKKLKKKKKKKHKDGER--GRRS----------------- 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SQGTYRAGAMRQVSLVGAVDEEVGDYFPEFINMLEESPFLERTLPWGTFSSLRLRIPTES DDGPIMWVRPGEQMIPVADMPKSPYKRK-------RSTNEIKN-LQYLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GE-GDAPARITKDVVCFHAGDFTEVVQRL QLDLYEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLRQYHL-------------------DQE----------------R--------- ------------------------------------------------------------ -----K------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ER EESCTSTQATSQVIEEA------------------------------------------- --------------EE----TE----------------------------------E--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SE---GGKEDTPTQ--TQVKTE--EAGG-RTPLQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------PPVC------------------------------- ------------------------------------------------------------ -----------------------------------------------------KEEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------DTQEEGGERGGCTSTLAFPLVKEERGEGNA VTETILEVKKRKEDDDHHKMEERARKRARDGSTPTQIPPQVLMEG--DG----------- 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STQPNPGIEEDGKVLSPRP----------------------------------------- ----------------------------------------TPSHV-KEGKRDRE------ -----------------VNHKDERKKPPPTPSCPPSYHK----P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PRTLVTFDLFK----------------------- -------------------------------------------------P-MDALQAPPL SLA----------------------DRS------------H------------------- ------------------------------------------------------------ --HSDCRGA--------------------------------------------------- -----------------------------------RSK--------------S------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ -------------AESVGSMHFA------------------------------------- ANGKTNPPKPLVPKIPPE-SRPQSSND----------------VY--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRIEEK-SLKHKKLNGDV--------------------------------- --------------------------------------VCAGEKH--N------------ ----------------GKQS---------------------------------------- -----------------------------------------------------------Y -GS--PAKWSFG------------------------------------------------ ----Q------------------------------------------------------- ------------------------------------------------------------ -------AKP-------------------------------------------------- ------------------------------------------------------------ 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----TKTENGDVK----------------------------------------MI----- -------------------------------------------------R---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D---HTI------------------------------- ------------------K-EEES----EKKKD------------------KERERDR-E -NNNHQ-VVIVSDVGREKGEVKSQLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-SAEKPSVNSEDELLLKKVKKKKKKKHKDGER--ERRY----------------- -------------R----AKMYHRSSQTVCSGVS-------------------------- ------------------------------VDLPD------------------------- 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DRTRAHADHIGQGFERQTTAAVGVLKAVRC-GE-GDAPARITKDVVCFHAGDFPDVVQRL QLDLYEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYHDDIYFIPRGVVHQFKTVSAVCS LAWHIRLRQYHP-------------------DQL----------------A--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PDSCTSTQATSQIKEEEVTDDSGGE----------------------------------- -----------EQNE--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ENTPTQ--TQIKTEVKEEGGERMPVQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------PLVH------------------------------- ------------------------------------------------------------ -----------------------------------------------------KEE---- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ENGGERRGSTPTLMLPLVKEEREEGAP LKDTLLGVKEGKEI-EHQKVEERERKGPRDSNTSTQ------MEG--DG----------- --ED-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ GDLSRASQHARIDREKEERQQRTPPKAQKDIEKEKDGCTATQTP---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------P---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------HV KKE------------------------------------KEKCKGKDFEK-------EER A------------------------REKERV----------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ --------------------------SLKH------------------------------ ----------------------------------P----------------------VKP HT-------T-------------------------------------------------- ------------------------HPQQK------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSSMAP00000000493 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADSLGSARLAGA-----------------------------AVAPAA AAAKSPLVKPTEAKGAPDNNRSQPSRD----------------FH--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEER-SAKPRKLSRDGGV--------G-G-------------------- -----------------------NG----------------------S-GREKL----PQ PAK--------------QQS---------------------------------------- -----------------------------------------------------------Y -GGSS---WSFS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AK--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------A-SGGSP PGVAAAAA-------------------------------AAAAAGAQTPTNTHK------ -----------------------VFKQSDFFLHKPP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----PSSRP----------------------KKPSRDRQRENEREKVPKGGGGEEEEEE EEEEEEEK----K-HKV------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------TLTSAPGSNV--PHNNNNNNNSS DTVNHISA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AKRENGDAP----------------------------------------SP----- ------------------------------------------------PK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------E---HSAKDKAKERDRE--------------------- -----------------ER-EKKK----VKDRE----------------------R---E -KKKHK-V--MNEIKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-EKEQAKINAE-ELQIKKVKKKKKKKHKEGEKHK--------------------- -------------R----VKMYHRSSQTICAGLL-------------------------- ------------------------------LPPPS------------------------- ---------------------SSSSAPDHTHNSSL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKTPLPV YSSPNNKTLH-MPSS--PP---------------------LASKALFNSS---------- ------------------------------LHNTPNSPSSSIKTPLPSLT-KPPR----- -----------------------------------------------------------Q CTYPGVAGLKFAPYIHIENQPNGGALVAHAYTSQLSSLSMGERQRFAQEFVTLAFSED-S SQAAHYVMGIVHGDASYLPDFLDYFSTKFPSAPVKMEILAKKDIETTTMANFYTQVKKTY SHGTYRAGAMRQISLVGAVDEEVGNYFPEFLSMLEQSPFLKRTLPWGTFSSLRPMSPEES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCS-GEGSE-PPRVTKDVVCFHAADFPYVVQRL QLDLYEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSAVCS LAWHVRLKQYHQ-------------------GEG----------------E--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE EE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EEE--- -----------------EEDD-----DDGDEE-------DKEG--KEEQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------VAR---------REKGG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------KGV-------KERIKEE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV YPSPNNKTSLLLPSS--PP---------------------LASKSLFNSS---------- ------------------------------LHDTPNSPSSSITTPLPSTA-KQQP----- -----------------------------------------------------------Q CTYPGMAGLEFAPYIHIEHQPNGGALVAHAYTSQLSSLSMGQRQRFAQEFVTLAFSED-S SQAAHYVMGIIHGEASYLPDFLDYFSTKFPSAPVKMEILGKKDIETTTMANFYTQVKKTY SHGTYRAGAMRQISLVGAVDEEVGNYFPEFLSMLEESPFLKRTLPWGTFSSLRLMSPTES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCS-GEGSE-PPRVTKDVVCFHAGDFPYVVQRL QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIRLSDEDIYFIPRNVVHQFKTVSAVCS LAWHVRLRQYHQ-------------------GEA----------------D--------- ------------------------------------------------------------ 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--------------------------A------------AKVKTEPPAPPLCKNKSPSPL PLSPPASR----------------------------------------------HP---- -----------------L-----HQD-TKP-KVSSKP--HH------------------- ---------HHHH------------------------HHH--------HHH--------- --HSDSRMT--------------------------------------------------- -----------------------------------SSSTA-------------------- --------------------------------SSSSSSSTSHSDPKSPRSPSFSKSS--- ----------------------------------TSSSS--------------------- -------------------------SAPSAGSTDTPPLRSSFAAPSPSSSTSSSVPGLST SSSTSASATSSLSS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------PK--------------------------PKADSHLS ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TLPPSTISSS--Y 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------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV YPSPNNKTLHLLPSS--PP---------------------LASKSLFNSS---------- ------------------------------LHDTPNSPSSSITTPLPSTA-KQQP----- -----------------------------------------------------------Q CTYPGMAGLEFAPYIHIEHQPNGGALVAHAYTSQLSSLSMGQRQRFAQEFVTLAFSED-S SQAAHYVMGIIHGEASYLPDFLDYFSTKFPSAPVKMEILGKKDIETTTMANFYTQVKKTY SHGTYRAGAMRQISLVGAVDEEVGNYFPEFLSMLEESPFLKRTLPWGTFSSLRLMSPTES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCS-GEGSE-PPRVTKDVVCFHAGDFPYVVQRL QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHEDIYFIPRNVVHQFKTVSAVCS LAWHVRLRQYHQ-------------------GEA----------------D--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE EE---------------------------------------------------------- ------------EAEE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EEE--- -----------------EEE---------------------EGDVKEEQK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ --KD-------------------------------------------------------- -RDSL-RPKADADSDTRTQVQSEVRA-SQGSPAV--------GVHT-------------- ----------------------------HTSQADARTHTV-------------------- ------------------------------------------------------------ ---ADTR---------------------------TQT----------LPEKWTHS--SDS RTS-ADPQIR------ATQDSGRQGIYMQQYTP-QHL-P--------------------- ---PP-P--------------------------------------HLPQMLPPSYSPLLP -HSHLPHRPPILPPNQLSNPSL-PAQPQTLNSYLSQKP-PPHSVHMSQLHLH---PPHQP NITTQSQPYYQPPLI---PSPP--HPNTPLTSSQSLPPHLSHH---HQF----AKTFYPP Q-------HPHFPSHPFLPPQSFL-SQ-PPGSYPLQP-QYQTSAPAQVQLSLSQPFP--- ------------------------------------------------------------ --------------HPPPPPSSSQTLPPLPPPL-P------------------------- ---------P-PLP-PQP------------------------------------------ --------------CPSVLSPPPKHEEER------------------------------- ---R-------------------------------------------------------- --------------------------------------------------------QIL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSAPOP00000008492 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MYHRSCQTICAGLL-------------------------- ------------------------------LLPGS-ASSSN------------------- ---------------------SSSAS-ELTNNSSL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV YS--NNKT-HLLSSS--PT---------------------LASKSLFNSS---------- ------------------------------LHNSVNSASSSTNT--PSPA-KHHP----- -----------------------------------------------------------Q CTYPGMAGLEFAPYIHIENQPNGGALVAHAYTSQLSSLSVDQRQRFAQEFVTLAFSED-S SQASHYVMGIIHGEANYLPDFLDYFSSKFPSAPVKMEILGKKDIETTTMANFYSQVKKTY SHGTYRAGAMRQISLVGAVDEEVGDYFPEFLTMLEESPFLKRTLPWGTFSSLRLMSPTES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCS-VESSE-PPRVTKDVVCFHAGDFPYVVQRL QLDLYEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSAVCS LAWHVRLQQYHQ-------------------GQG----------------D--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE EE---------------------------------------------------------- ------------VKEE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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---SESRTM--------------------------------------------------- ------------------------------------------------------------ ------------------------------SSSTNFSSSASHSASKSSLSP--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PFCKSS--------------------- ---TSSSPGSSVTSLHSSFAASHPSSTSSPSA---------------------------- ---------VLSTSSSVASSSPTRPK--------------------------PAANSSLT ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TRPPPSASSS--- ----SSQSDQPNKDKDHLKPHV-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LSDTRTQT----------SAAV--------DVQT-------------- ----------------------------HTCQADTRTHTA-------------------- ------------------------------------------------------------ ---ADTR-----------------------------TLAE--MRTQTLPEKWTHSSDSDS RSS-VDLQMH------PPQD--RQGVYMQQYTP-QHLP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSAPEP00000004753 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADSQGSVHLPGATA-----------------------AAPTSV---- ---KSAHGKPTEAKAATD-NRSQASRD----------------FN-QPPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEET-SVKPKKLSREGGV--------G-G-------------------- -----------------------NG----------------------S-GKEKLQQQQQQ PTK--------------QQS---------------------------------------- -----------------------------------------------------------Y -GSSNAGLWSFS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------VKT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSSSGGGGG---------SSTNPPVPA-TGGSQ P---------------------------------------------------HK------ -----------------------VFKQSDFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SSSKP----------------------KKPSKDKQREKEREK-GKGGG------- ----EEKK----K-HKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-EKEKAKINLE-ELQIKKVKKKKKKKHKEGEKHK--------------------- -------------R----VKMYHRSCQTICAGLL-------------------------- ------------------------------LLPGS-ASSPN------------------- ---------------------SSSSSSELTNNSSL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV YP--NNKT-HLLSSS--PP---------------------LTSKSLFNSS---------- ------------------------------LHNSHNSASSSTKTPLPSPT-KHHP----- -----------------------------------------------------------Q CTYPGMAGLEFAPYIHIENQPNGGALVAHAYTSQLSSLSVDQRQRFAQEFVTLAFSED-S SQASHYVMGIIHGEAKYLPDFLDYFSSKFPSAPVKMEILGKKDIETTTMANFYSQVKKTY SHGTYRAGAMRQISLVGAVDEEVGDYFPEFLGMLEESPFLKRTLPWGTFSSLRLMSPTES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCS-VESSE-PPRVTKDVICFHAGDFPYVVQRL QLDLYEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSAVCS LAWHVRLQQYHQ-------------------GEG----------------D--------- ------------------------------------------------------------ -----Q------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE EE---------------------------------------------------------- ------------VKEE-------------------------------------------- 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----P------------------------------------------------------- ------------------------------------------------------------ -------VKT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSS----GG---------SSTNPPVPA-TGGSQ P---------------------------------------------------HK------ -----------------------VFKQSDFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SSSKP----------------------KKPSKDKQREKEREK-GKGGG------- ----EEKK----K-HKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LLTSGPGSNA--SSNN----NDI SRLNNVSA---------------------------------------------------- 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------------------------------------------------------------ ----D-EKEKAKINLE-ELQIKKVKKKKKKKHKEGEKHK--------------------- -------------R----VKMYHRSCQTICAGLL-------------------------- ------------------------------LLPGS-ASSPN------------------- ---------------------SSSSSSELTNNSSL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV YP--NNKT-HLLSSS--PP---------------------LTSKSLFNSS---------- ------------------------------LHNSLNSASSSTKTPLPSPT-KHHP----- -----------------------------------------------------------Q CTYPGMAGLEFAPYIHIENQPNGGALVAHAYTSQLSSLSVDQRQRFAQEFVTLAFSED-S SQASHYVMGIIHGEAKYLPDFLDYFSSKFPSAPVKMEILGKKDIETTTMANFYSQVKKTY SHGTYRAGAMRQISLVGAVDEEVGDYFPEFLGMLEESPFLKRTLPWGTFSSLRLMSPTES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCS-VESSE-PPRVTKDVICFHAGDFPYVVQRL QLDLYEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSAVCS LAWHVRLQQYHQ-------------------GEG----------------D--------- ------------------------------------------------------------ -----Q------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE ED---------------------------------------------------------- ------------VKEE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ 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---------------------------------PFSKSSA-------------------- ---SSFSPGSSVTSLHTSFAAPHPSSTSSPSA---------------------------- ---------VLSTSSSTSSSSPIWPK--------------------------PTADANLC ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TRPPSSVSSS--- ----SSQSDQP-KDKDRLKPDV-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LSDTRTQA----------SPAV--------DVQT-------------- ----------------------------HTYQADTRTHTA-------------------- ------------------------------------------------------------ ---ADT-------------------------------------RTQTLPEKWTHSLDSDS RSS-VDLQMH------PPQD--RQGIYMQQYTP-QHLPPPP------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------NEIKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-EKEKAKINSE-ELQIKKVKKKKKKKHKEGEKHK--------------------- -------------R----VKMYHRSCQTICAGLL-------------------------- ------------------------------LLPPS-SPSPT------------------- 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DRTRAHADHIGQGFERQTTAAVGVLKAVCF-GEGSE-PPRVTKDVVCFHAGDFPYVVQRL QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSAVCS LAWHVRLKQYHQ-------------------GEG----------E----DE--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE EE---------------------------------------------------------- ------------VKEE----------------------------------------K--- -P----------------------------------------------KEKEMEAALEEK E---------------------------------------------EGEGRREKKS---- ---------EKGG-----------------KERIKEE---------------EGEEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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-------------ADSQGSAHLTGAAA-----------------------AAATAVAPAV TSAKSPLVKPTEAKGAPD-NRSQSSRD----------------FNPPPPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEER-SVKPKKLSREGGV--------G-G-------------------- -----------------------NG----------------------SGGKEKL----QQ PAK--------------QQS---------------------------------------- -----------------------------------------------------------Y -GNS-TGLWSLS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------VKT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SGNN-----------------NPPVPA-TGGSQ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------E---HSNKDKAKERDRE--------------------- -----------------ER-EKKK----VKDRE----------------------REK-E -KKKHK-V--VNEIKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-EKEKAKINSE-ELQIKKVKKKKKKKHKEGEKHK--------------------- -------------R----VKMYHRSCQTSCAGLL-------------------------- ------------------------------LIPPS-SPTTT------------------- ---------------------TSP----PSSNSPL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV YPPPNNKTAHLLPSS--PP---------------------LASKPLINSS---------- ------------------------------LNNSP---SSSIKTPQPFPT-KHQP----- -----------------------------------------------------------Q CTYPGTAGLEFAQYIHIEEQPNGGALVAHAYTSQLSSLSMGQRQRFAQEFVTLAFSED-S SQAAHYVMGIVHGEASYLPDFLDYFSTKFPSAPVKMEILGKKDIETTTMANFYSQVKKTY SNGTYRAGAMRQISLVGAVDEEVGDYFPEFLGMLEESTFLKRTLPWGTFSSLRLMNPTES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSLPRASEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVGAGGESSE-PPRVTKDVVCFHAGDFPHVVQRL QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSSVCS LAWHIRLKQYHQ-------------------GEG------KEEEE----QE--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE EE---------------------------------------------------------- ------------VKEE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ---------------------A-------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EEVDVAG NRTLPAVKKEE------------------------------------------------- ----------------------------------------------PHPPLSSQPAPSAD S----------------------------------------------------------- ------------------------------------------------------------ ------------------NVSSARDKEEET------AGGKPK------------------ ----QQ------------------------------V----------------------- -------------------------------------------------S---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ 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------------------------------------------------------------ --------------------------------------------------------S--- ----SSKSDQP-RDSHRLKPDVPSD--------------------ILVSCGLPATDVQTH TSAS-----SQADTR----THTVAR------------------------------MPTDS WTHQD--------------------------------KWTRVADSRTS------------ ---------MEPQTHPPP------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DTGRPGMYMQQYTP-QHLPPPP------------------- ---PP-PP-----------------------------------HHHHPHMLPPSFPPLLP -HSHLPHRPPILPP---SSP-L-PAQAQTLNSYLSQKA-PPHSIHISQLHLH---PPHQP NITTQSQPYYQPPLM---GCPS--QPNTPHSSSQSLPPHLSHH---HQYMNPHAKTFYPS Q-------HPHFPSHHFLPPQSFL-SQ-PPGSYPLQP-QYQPSAP---------PFP--- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------VKKKKKKKHKEGDKRK--------------------- -------------Q----VKMYHQSCQTMCAGLF-------------------------- ------------------------------L-PPS-SP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PPTPSPT-KQQP----- -----------------------------------------------------------Q CTYPGMAGLEFAPYIYIENQPNGGALVAHAYTSQLSSLSMAQRQRFAQEFVTLAFSED-S SQAAHYVMGIVHGEASQLPDFLDYFSTNFPSAPVKIEILGKKDIETTTMANFYSQVTKTY SNGTYRAGAMRQISLVGAVDEEVGDYFPEFLGMLEESPFLKRTLPWGTFSSLRLMNPTES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHA-GESSE-PPRVTKDVVCFHAGDFSHVVQRL QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIHLCHNDIYFIPRNVVHQFKTVSSVCS LAWHVRLKQYHQ-------------------G------------------E--------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MYHRSCQTICAGLF-------------------------- ------------------------------LLPPS-SPSPTSS----------------- --------------------SSSSSSSDPSHNSSL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV YPPPNNKTAHFLPSS--PH---------------------LA------------------ ------------------------------------------------------PKSLLN CALLDSLNSTSSSMKTQT---------------------------------------KHQ CTYPGMGGLEFAPYIHIENQPNGGALVAHAYTSQLSSLSMGERQRFAQEFVTLAFSED-S SLAAHYVMGIVHGEAGYLPDFLDYFSTKFPTAPVKMEILGKKDIETTTMVNFYSQVKKTY SNGTYRAGAMRQISLVGAVDEEVGDYFPEFLGMLEESPFLKRTLPWGTFSNLKSMDPTES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVRA-GGSSE-PPRVTKDVVCFHAGDFPHVVQRL QLDLYEPPLSQCVQWVDDAKLNQLRREGIHYARIRLCHDDIYFIPRNVVHQFKTVSSVCS LAWHVRLRKYHH-------------------GAG----------------D--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------QVRNIKNFGLQSCMAAPVLTLKIIILLKV------ ------------------------------------------------------------ ------ >ENSMAMP00000014534 ------------------------------------------MLGYRLIPASSFSLSACQ SSISPAPFVSACQSNLCPAPSLPSCMSR-------------------------------- ------------------------------------------------------------ ----------------------------------------------------KKQQ--RP LRKRVNRERSLKMADSQGSVHLVG--------------------------AAASAVSPPV ASTKSPLVKQTEAKGAPD-NRSQGSRD----------------FN--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEER-SIKPKKLSREGGV--------G-G-------------------- -----------------------NG----------------------S-GKEKL----QQ PAK--------------QQS---------------------------------------- -----------------------------------------------------------Y -GSS-AGLWSFS------------------------------------------------ ----Q------------------------------------------------------- ------------------------------------------------------------ -------VTT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSN------------------NPPVPA-TGGSQ P-----------------------------------------------PTNTHK------ -----------------------VFKQSDFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----STSKP----------------------KKPSKDKQREKEREK-GKGGG------- ----EEKK----K-HKL------------------------------------------- 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VSVDSNDSSDADRKEESKRAKEDEKP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------K------------------ ----QQ------------------------------G----------------------- -------------------------------------------------S---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------S---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------AKATADPQAPPVYKNKSPSPL PPSPPASL----------------------------------------------HS---- -----------------P-----LQG-IKP-RASSKP--QQ------------------- ---------HHYH------------------------HH--------------------- ---SDSRMT--------------------------------------------------- -----------------------------------SS----------------------- ------------------------------SSTSSSSSSASHLAPKSSLSPSFSRS---- -----------------------------------SSSSAGFTDAS-------------- --------------------LCSSFAAPSV------------------SSTASFVPVLST SSSVSTSATSSQTG---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------PK--------------------------PSAGSH-- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------ASTVSSS--C QQPPSSQTDQP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KD-------------------------------------------------------- -KDSL-WLKPDVYSDTRTQS--EIRP-SQGSPAV--------DLQT-------------- ----------------------------HTSQADTWTHTQ-------------------- ------------------------------------------------------------ ---ADI-------------------------------------RTQTLPEKWMHSLDSDS RMS-LDPQMC------TPQDSGRRGIYMQQYAP-QHLP---------------------- ----P-P--------------------------------------QLPQMLPPSFPSLLP -HSHLPHRPPVLPPNPLSNPSL-SAQPQTLNSFLGQNP-APHSVHMSQLHLH---PPHQP NITTQSQPYYQP----------------ALSSSQSLPPHLPHH---HQF----AKTFFPP Q-------HPHFSSHPFLPPQSFL-SQ-PPSSYPLQP-QYQTSAPVQVQLPLSQSFP--- ------------------------------------------------------------ --------------HPPPPPSSSLSPPPPPPPL-P------------------------- ---------P-PLP-PQ------------------------------------------- ---------------PSVLSPPQMHEEEQ------------------------------- ---K-------------------------------------------------------- --------------------------------------------------------QIL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPFOP00000016793 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADSQGSVHLSGALVVAPSP-----------------SAAG------- ASVKNGLGKATESKGAAD-NRPQCSGD----------------FS--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEDR-SVKPKKVSKDGGD--------G-N-------------------- -----------------------NG----------------------S-GKKKT----QQ LTK--------------QQN---------------------------------------- -----------------------------------------------------------C -SSSNAGLWSFS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------GKT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSSS-----------------NPPVPA-TDGSQ P---------------------------------------------------LK------ -----------------------VFKQSDFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----S-SKT----------------------K--CKDKQK--EREK-RKEGG------- ----EEKK----R-HKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LVTSGVGNNV---TNS----NDI KGFNNVSA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AKRENGDVL----------------------------------------LP----- ------------------------------------------------SK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------E---NPNKDKMK-------------------------- -----------------AR-EKKK----VK--E----------------------REK-E -KKKHK-V--MNEIKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-ETEKAKIKLE-ELQIKKVKKKKKKKHKDGEKHK--------------------- -------------R----VKMYHRSCQTICAGLL-------------------------- ------------------------------LLPPPPSSSAN------------------- ----------------------SFSSSEQTNDSSA------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPPPV YLTPNNKNSNLWPSSPPPP---------------------PASKSLFNSSNS-------- -------------------------K-------------------LPFST-KRNS----- -----------------------------------------------------------Q SIHPGMAGLEFAPYIYIENQPNGGALVAHAYASQLSSLSVDQRQRFAQEFVTLSFSED-Q SKAAHYVMGIVHGEAKNLPDFLDYFSTKFPSAPVKMEILGKKDIETTTMASFCSQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLSLLEESPFLERTLPWGTLSSLRNMSPAKS DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSMPRTSEPREVLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCT-VERSE-PPRVTKDVVCFHAGDFPYVVERL QLDLYEPPLSQCVQWVDDAKLNQLRREGIRYARIQLCHDDIYFIPRNVVHQFKTVSAVCS LAWHIRLQQYHQ------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E EE---------------------------------------------------------- ------------VKEK-------------------------------------------- ------------------------------------------------------ATVK-- ------------------------------------------------------------ ------------------------------------------------------EEE--- -------TLILA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------QGGEK------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KERIKGE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------E-------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EEVAVAD KWTLLTDKKEEGDDRLLSPQPS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DDISDASRDEEEAMRRKEEPHRVS---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------EKMKTEAPTSPPCKNKSPSPL HLPPPASP----------------------------------------------H----- ------------------------KD-VKS-KASAKP--HL------------------- ---------HSP------------------------------------------------ ---PGSRTA--------------------------------------------------- -----------------------------------ASS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------SSQKPPGC------------------------------------- -----------------------------------SKSSARASSSPPAGAAFTSSHTVSS TS---------------------------------------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SPSASSPSLTSPTSAAEALVKTLPPSRVSSS--L QLHSSSHSEQP------------------------------------------------- ------------------------------------------------------------ ----DDSRTKDSARSPAPS----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------DVQTCSAP---------- ------------------------------------------------------------ -------------------------------------AERWTR----------------- -PAADTR---------------------------TQTASDSETRT--------RGSDPDS RTC-VDVQQR------LAPDMTRGGVYMQQY----------------------------- ---PP-Q--------------------------------------HLPQMLPPPFPPLLP PHSHL--QPHILPQTPVSS----PHEHRPLNSFLSQ------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------A- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPLAP00000011915 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADSQGSVHLSGALVVAPSP-----------------SAAG------- ASVKNGLGKATESKGAAD-NRPQCSGD----------------FS--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEDR-SVKPKKVSKDGGD--------G-N-------------------- -----------------------NG----------------------S-GKKKT----QQ LTK--------------QQN---------------------------------------- -----------------------------------------------------------C -SSSNAGLWSFS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------GKT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSSS-----------------NPPVPA-TDGSQ P---------------------------------------------------LK------ -----------------------VFKQSDFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----S-SKT----------------------K--CKDKQK--EREK-RKGGG------- ----EEKK----R-HKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LVTSGVGNNV---TNS----NDI KGFNNVSA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AKRENGDVL----------------------------------------LP----- ------------------------------------------------SK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------E---NPNKDKMK-------------------------- -----------------AR-EKKK----VK--E----------------------REK-E -KKKHK-V--MNEIKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-ETEKAKIKLE-ELQIKKVKKKKKKKHKDGEKHK--------------------- -------------R----VKMYHRSCQTICAGLL-------------------------- ------------------------------LLPPPPSSSAN------------------- ----------------------SFSSSEQTNDSSA------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPPPV YLTPNNKNSNLWPSSPPPP---------------------PASKSLFNSSNS-------- -------------------------K-------------------LPFST-KRNS----- -----------------------------------------------------------Q SIHPGMAGLEFAPYIYIENQPNGGALVAHAYASQLSSLSVDQRQRFAQEFVTLSFSED-Q SKAAHYVMGIVHGGAKNLPDFLDYFSTKFPSAPVKMEILGKKDIETTTMANFCSQVKRTY SHGTYRAGAMRQISLVGAVDEEVGDYFPEFLSLLEESPFLERTLPWGTLSSLRNMSPAKS DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSMPRTSEPREVLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCT-VERSE-PPRVTKDVVCFHAGDFPYVVQRL QLDLYEPPLSQCVQWVDDAKLNQLRREGIRYARIQLCHDDIYFIPRNVVHQFKTVSAVCS LAWHIRLQQYHQ------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E EE---------------------------------------------------------- ------------VKEK-------------------------------------------- ------------------------------------------------------ATVK-- ------------------------------------------------------------ ------------------------------------------------------EEE--- -------TLILA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------QGGEK------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KERIKGE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------E-------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EEVAVAD KWTSHTDKKEEGDDRLLSPQPS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DDISDASRDEEEAMRRKEEPHRVS---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------EKMKTEAPTSPPCKNKSPSPL HLPPPASP----------------------------------------------H----- ------------------------KD-MKS-KASAKP--HL------------------- ---------HSP------------------------------------------------ ---PGSRTA--------------------------------------------------- -----------------------------------ASS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------SSQKPPGC------------------------------------- -----------------------------------SKSSASASSSPPAGAAFTSSHTVSS TS---------------------------------------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SPSASSPSLTSPTSAAEALVKTLPPSRVSSS--L QLHSSSHSEQP------------------------------------------------- ------------------------------------------------------------ ----DDSRTKDSTRTPAPS----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------DVQTCSAP---------- ------------------------------------------------------------ -------------------------------------AERWTR----------------- -PAADTR---------------------------TQTASDSETRT--------RGSDPDS RTC-VDVQQR------LAPDMTRGGVYMQQY----------------------------- ---PP-Q--------------------------------------HLPQMLPPPFPPLLP PHSHL--QPHILPQTPVSS----PHEHRPLNSFLSQAA-PPHSVHLG--HLH---PPHPP SLTTQSQPYFMGP---PSSSPS--QPNAPLTSSQSLSPHFSYH---HQF----AKPFFPP Q-------HPGFPSHPFLPHQSFL-PQ-PPTSYPLQP-QYQTSASVHPQLLMSQSFTSP- ------------------------------------------------------------ --------------HPPPPPSST--PPPPPPPF-P------------------------- ---------P-PPPLPQS------------------------------------------ --------------SPSIFPSPPE------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------A- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPMEP00000021230 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADSQGSVHLSGALVVAPSP-----------------SAAG------- ASVKNGLGKATESKGAAD-NRPQCSGD----------------FS--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEDR-SVKPKKVSKDGGD--------G-N-------------------- -----------------------NG----------------------S-GKKKT----QQ LTK--------------QQN---------------------------------------- -----------------------------------------------------------C -SSSNTGLWSFS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------GKT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSSS-----------------NPPVPA-TDGSQ P---------------------------------------------------LK------ -----------------------VFKQSDFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----S-SKT----------------------K--CKDKQK--EREK-RKEGG------- ----EEKK----K-HKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LVTSGVGNNV---TNS----NDI KGFNNVSA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AKRENGDVL----------------------------------------LP----- ------------------------------------------------SK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------E---NPNKDKTK-------------------------- -----------------AR-EKKK----VK--E----------------------REK-E -KKKHK-V--MNEIKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-ETEKAKIKLE-ELQIKKVKKKKKKKHKDGEKHK--------------------- -------------R----VKMYHRSCQTICAGLL-------------------------- ------------------------------LLPPPPSSSAN------------------- ----------------------SFSSSEQTNDSSA------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPPPV YLTPNNKNSNLWPSS-PPP---------------------PASKSLFNSSNS-------- -------------------------K-------------------FPFST-KRDS----- -----------------------------------------------------------Q SIHPGMAGLEFAPYIYIENQPNGGALVAHAYASQLSSLSVDQRQRFAQEFVTLSFSED-Q SKAAHYVMGIVHGEAKNLPDFLDYFSTKFPSAPVKMEILGKKDIETTTMASFCSQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLSLLEESPFLKRTLPWGTLSSLRNMSPAKS DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSMPRTSEPREVLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCT-VERSE-PPRVTKDVVCFHAGDFPYVVERL QLDLYEPPLSQCVQWVDDAKLNQLRREGIRYARIQLCHDDIYFIPRNVVHQFKTVSAVCS LAWHIRLQQYHQ-------------------EE--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE EE---------------------------------------------------------- ------------VKVK-------------------------------------------- ------------------------------------------------------APVK-- ------------------------------------------------------------ ------------------------------------------------------EEE--- -------TLILA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------QGREK------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KERIKGE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------E-------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EEVAVAD KWTLLTDKKEEGDDRLLSPQPS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DDISDASRDEEEVMRRKEEPHRVS---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------EKMKTEAPTS-PCKNKSPSPL HLPPPASP----------------------------------------------H----- ------------------------KD-VKS-KASAKP--HL------------------- ---------HSQ------------------------------------------------ ---PGSRTA--------------------------------------------------- -----------------------------------ASS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------SSQKPPGC------------------------------------- -----------------------------------SKSSARASSSPPAGAAFTSSHTVSS TS---------------------------------------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SPSASSPSLTSPTSAAEALVKTLPPSRVSSS--L QLHSSSHSEQP------------------------------------------------- ------------------------------------------------------------ ----DNSRTKDSARSPAPS----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------DVQTCSAP---------- ------------------------------------------------------------ -------------------------------------AERWTR----------------- -PAADTR---------------------------TQTASDSETRT--------RGSDPDS RTC-VDVQQR------LAPDMTRGGVYMQQY----------------------------- ---PP-Q--------------------------------------HLPQMLPPPFPPLLP PHSHL--QPHILPQTPVSS----PHEHRPLNSFLSQAAPPPHSVHLG--HLH---PPHPP SLTTQSQPYFMGP---PSSSPS--QPNAPLTSSQSLSSHFSYH---HQF----AKPFFPP Q-------HPSFPSHPFLPHQSFL-PQ-PPASYPLQP-QYQTSASVHPQLLMSQSFTSP- ------------------------------------------------------------ --------------PPPPPPSST--PPPPPPPF-P------------------------- ---------P-PPPLPQS------------------------------------------ --------------SPSVFPSPPE------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------A- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSXMAP00000004101 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AKKKKKKKHKDGEKHK--------------------- -------------R----VKMYHRSCQTICAGL--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PSS--PP---------------------PASKSLFNSSNS-------- -------------------------K-------------------LPFST-KHNS----- -----------------------------------------------------------Q SIHPGMAGLEFAPYIYIENQPNGGGLVAHAYASQLSSLSVDQRQRFAQEFVTLSFSED-K SKAAHYVMGIVHGEAKNLPDFLDYFSTKFPSAPVKMEILGKKDIETTTMANFYSQVKRTY SHGTYRAGAMRQISLVGAVDEEVGDYFPEFLSLLEESPFLKRTLPWGTLSSLRNMSPTKS DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSMPRTSEPREILFE DRTRAHADHIGQGFERQTTAAVGVLKAVCT-VERSE-SPHVTKDVVCFHAGDFPYVVQRL QLDLYEPPLSQCVQWVDDAKLNQLRREGIRYARIQLCHDDIYFIPRNVVHQFKTVSAVCS LAWHVRLQQYHQ-------------------EEKD-----DEEEEKAGLKE--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E ETTTAEEQVLKMNGSSSSCLCYRSMNRS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSXCOP00000018498 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AKKKKKKKHKDGEKHK--------------------- -------------R----VKMYHRSCQTICAGL--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PSS--PP---------------------PASKSLFNSSNS-------- -------------------------K-------------------LPFST-KHNS----- -----------------------------------------------------------Q SIHPGMAGLEFAPYIYIENQPNGGGLVAHAYASQLSSLSVDQRQRFAQEFVTLSFSED-K SKAAHYVMGIVHGEAKNLPDFLDYFSTKFPSAPVKMEILGKKDIETTTMANFYSQVKRTY SHGTYRAGAMRQISLVGAVDEEVGDYFPEFLSLLEESPFLKRTLPWGMLSSLRNMSPTKS DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSMPRTSEPREILFE DRTRAHADHIGQGFERQTTAAVGVLKAVCT-VERSE-SPHVTKDVVCFHAGDFPYVVQRL QLDLYEPPLSQCVQWVDDAKLNQLRREGIRYARIQLCHDDIYFIPRNVVHQFKTVSAVCS LAWHVRLQQYHQ-------------------EEK------DEEEEKAGLKE--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E ETTTAEEQVLKMNGSSSSCLCYRSMNRS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSGAFP00000027307 ------------------------------------------MG---------------- --------------------------VRNSHHQSPEDSPCRNFHVP-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------IS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------KIKLE-ELQIKKVKKKKKKKHKDGEKYK--------------------- -------------R----VKMYHRSCQTICAGLL-------------------------- ------------------------------LLPPPPSSSSN------------------- ----------------------SFSFPEQTNNSSA------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPPPV YLTSNNKNSNLRPSS--PP---------------------PASKSLFNSSNS-------- -------------------------K-------------------LPVST-KHNS----- -----------------------------------------------------------Q RIHPGMAGLEFAPYIYIENQPNGGALVAHAYASQLSSLSVDQRQRFAQEFVTLSFSED-Q SKAAHYVMGIVHGEAKNLPDFLDYFSTKFPSAPVKMEILGKKDIETTTMANFYSQVKRTY SHGTYRAGAMRQISLVGAVDEEVGDYFPEFLSLLEESPFLKRTLPWGTLSSLRNMSPTKS DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSMPRTSEPREILFE DRTRAHADHIGQGFERQTTAAVGVLKAVCT-VERSE-PPHVTKDVVCFHAGDFPYVVERL QLDLYEPPLSQCVQWVDDAKLNQLRREGIRYARIQLCHNDIYFIPRNVVHQFKTVSAVCS LAWHVRLQQYHQ-------------------EEK------GEEEEKAGLKE--------- ------------------------------------------------------------ -----EK----------------------------------------------------- ------------------------------------ET---------------------- ------------------------------------------------------------ ---------------------------------------------------------AM- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------A------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------QGGEK------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KERIK---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EEVDVAE KRTLLADKKEEGDDRLLSCQPS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DDISDAGRDEEEATRKKEEPHWVS---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------QKAKVVAPTSPPCKNKSPSPL HLPPPVSP----------------------------------------------H----- ------------------------MD-VKS-KASAKP--HL------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXX-------------- -----XXX----XXSPSIFPPPPK------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------A- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPREP00000007115 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MYHRSCQTICAGLL-------------------------- ------------------------------LLPPPPSSSAN------------------- ----------------------SFSSSEQTNDSSA------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPPPV YLTPNNKNSNLWPSS-PLP---------------------PASKSLFNSSNS-------- -------------------------K-------------------LPFST-KRNL----- -----------------------------------------------------------Q SIHPGMAGLEFAPYIYIENQPNGGALVAHAYASQLSSLSVDQRQRFAQEFVTLSFSED-Q SKAAHYVMGIVHGEAKNLPDFLDYFSTKFPSAPVKMEILGKKDIETTTMANFCSQVKRTY SHGTYRAGAMRQISLVGAVDEEVGDYFPEFLSLLEESPFLKRTLPWGTLSSLRNMSPAKS DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSMPRTSEPREILFE DRTRAHADHIGQGFERQTTAAVGVLKAVCT-VERSE-PPRVTKDVVCFHAGDFPHVVQRL QLDLYEPPLSQCVQWVDDAKLNQLRREGIRYARIQLCHDDIYFIPRNVVHQFKTVSAVCS LAWHVRLKQYHQ-------------------EE--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE EE---------------------------------------------------------- ------------VEEK-------------------------------------------- ------------------------------------------------------AAVK-- ------------------------------------------------------------ -------------------------------------------------------EE--- -------TLILA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------QGGEK------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KERIKEE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------E-------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EEVAVAD KRTLLTGKKEEGDDRLLSPQNS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DDISDASRDEEEATRRKEEPHRVS---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------EKMKTEAPTSPPYKNKSPSPL HLPPNASP----------------------------------------------H----- ------------------------KD-VKS-KASAKP--HL------------------- ---------HSH------------------------------------------------ ---PDSRTA--------------------------------------------------- -----------------------------------SSS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------LPQKSPGC------------------------------------- -----------------------------------SKSSARVSSSPPAVAAFTSSHTVSS TS---------------------------------------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SPSASSLSLTSPASAAEALLKTLPPSTVSSS--L QLHSSSHSEQP------------------------------------------------- ------------------------------------------------------------ ----DDSRTKDSVRTPVPSDL--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------RKP-PQGRLAA--------DVQIRSSP---------- ------------------------------------------------------------ -------------------------------------AERWTR----------------- -PVADTR---------------------------TQTASDLETRT--------RDSDPDS RTC-VDVQQH------LALDGTRRGVYMQQY----------------------------- ---PP-Q--------------------------------------HLPQILPPPFPPLLP SHSHL--QPRVLPQTPVSS----PHEQRPLNSFLSQAA-PPHSVHLG--HLQ---PPHPP SLTTQSQPYFMVP---PSSSPS--QPNAPLTSSQSLSPHFSYH---HQF----AKPFFHP Q-------HPGFPSHPFLPHQSFL-PQ-PPASYPLQP-QYQTSAPVQPQMLLSQSFTSPX XXXXXXXXXXXXXXXXXXXXSRHLPPCLSPPLPSFPLPPKHDNK--------------QK QILYRSIC---TYRW--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCVAP00000001559 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADSEGSAHL---------P-----------------GAAAVPLSPPR ASVKNGLAKVT-----AD-SHPQYSGA----------------SS--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKLRVEER-SVKPKKVSKYGAD--------G-S-------------------- -----------------------NGKKKPQLQSCGS-----------S-G---------- ------------------------------------------------------------ ------------------------------------------------------------ ----SAGLWSFS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------VK--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ASSS-----------------DQPVPA-TGGSQ P---------------------------------------------------LK------ -----------------------VFKQSDFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----S-SKP----------------------K--SKDKQKEREREK-GKGGG------- ----EEKK----K-HKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LLTSSVGNNV--SSSS----NAI KGYINISA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AKRENGDVL----------------------------------------LP----- ------------------------------------------------SQ---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------E---NPCKDKKK-------------------------- -----------------ER-ERKK----VK--E----------------------REK-E -KKKHK-V--MNEIKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-EREKVNINSE-ELQIKKVKKKKKKKHKEGEKHK--------------------- -------------R----VKMYHRSCQTVCAGLL-------------------------- ------------------------------LLPPS-STAAN------------------- ----------------------SLSSAEQTNNSAS------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV YLSPDDENSKFWPSS--PPSKSSFCSSP----------LKP------------------- ----------------------------------------------PFST-KHAS----- -----------------------------------------------------------K SIHPGKAGLEFAPYIYIENHPNGGALVAHAYASQLSSLSLDQRQRFAQEFVTLSFSED-S SKAAHYVMGIVHGEAKNLPDFLDYFSTKFPSAPVKMEILGKKDIETTTMANFYSQVKRTY SNGTYRAGAMRQISLVGAVDEEVGDYFPEFLSMLEESPFLKRTLPWGTLSSLRGMSPTKS DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSMPRTSEPREVLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCA-VESSE-PPRVTKDVVCFHASDFPYVVQRL QLDLYEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSAVCS LAWHVRLQQYHQ-------------------KE--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ---------------------------------------------EQ------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------QSELKEE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------EN------------------------------------- ------------------------------------------------------VAVT-- -------------------KEQDGEK-------RENEV--------------KEEVDVAD KRTLLTEVKEEQDDRPLSAQPSL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SDVSKDEELET---------- ----------------GRKEDEKPRWD----------------------S---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------S---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------SKAKAEAPAS-PCKKESASP- -LPPPASPS--------------------------------------------SH----- ------------------------KD-MKS-KGSAKPLPHL------------------- ---------HS------------------------------------------------- ----DSRTG--------------------------------------------------- -----------------------------------SS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GTNV---PPLAQKSSCSP--------------------- ---------------------------------PYSKSSTCVSSSPSAGTAFTSSHTLSS TS---------------------------------------------------------- ------------------------PP---------------------------------S SV---------------------------------------------------------- ------------------------------------------------------------ ----------------------LPTSSPSTSSSSLTSPKSAAESLLKALPPSNGSSS--C QL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------PA--------- -----------------SSQSDNKDLIART-QA--------------------------- ------QSDV----------RMSQGR---------PAADRWTH----------------- -PATETR---------------------------TQTPSESETRT--------HSTDSDS RTF-SDLHKH------LAPDASRPGVYMQQY----------------------------- ---PS-P--------------------------------------HLPQMLPPPFSPLLP -HSHLPHQPPILQQNPISSH---PHEQRSLNSFLSQAG-PPHSVHLN--HPY---PPPQP SLSSQSHSYFQPPLMSPSSSSS--Q---PLTSSQSVPPHFSYH---HQF----AKTFFPP Q-------HSGYPSHPFLPHQSFL-PQ-PPGSYPLQP-QYQTPGPMQPQLHLSQSFTPP- ------------------------------------------------------------ --------------QPPPPPSST--PPPPPPPF-P------------------------- ---------P-PPPFPQH------------------------------------------ --------------SPSIFPPPPRHDDEQ------------------------------- ---K-------------------------------------------------------- --------------------------------------------------------QIL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSFHEP00000032451 ------------------------------------------M----------------- --------------------------------------------VSET------------ ----------------------------------------LVLSFIFTLTCVRVFKTSRG RAVVYLFRLAPPTAVSHNMTTPLISYLSSKAVAPPPSQTASTSRKKKKKKKKKKQQQPRP LGKRVNRGRSLKMADSQGSVHLSGAAAVATSP-----------------SAAG------- ASVKNGLGKATESKGAAD-SHPQCSGD----------------FS--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KNVRVEER-SVKSRKVGKDVGD--------G-S-------------------- -----------------------NG----------------------S-GKKKT----QQ LTK--------------QQS---------------------------------------- -----------------------------------------------------------C VSSGSAGLWSFS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------VRT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TSSSVP-GG---------GGGNPPVPA-TGGSQ P---------------------------------------------------LK------ -----------------------VFKQSDFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----S-SKP----------------------K--CKDKQKEKEREK-GKGGG------- ----EEKK----K-HKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LLTSGVGNNV---SNS----NAI KGFNNISA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AKRENGDVL----------------------------------------LP----- ------------------------------------------------SQ---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------E---SPNKEKTK-------------------------- -----------------ER-QKKK----VK--E----------------------REK-E -KKKHK-V--MNEINRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-EKEKAKINSE-ELQIKKVKKKKKKKHKDGEKHK--------------------- -------------R----VKMYHRSCQTICVGLL-------------------------- ------------------------------LLPPS-SPSAN------------------- ----------------------SFPSSEQINTSPP------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPPAV YLTPNSKTSNLGPTS-PPP---------------------PPSNSTCSFSNS-------- -------------------------K-------------------IPFSE-KHHS----- -----------------------------------------------------------E SIHPGVAGLEFAPYIYIEKQPNGGALVAHAYASQLSSLSVDQRHRFAQEFVTLSFSED-P SKAAHYVMGIVHGEAKNLPDFLDYFSTKFPSAPVKMEILGKKDIETTTMANFYSQVRRTY SHGTYRAGAMRQISLVGAVDEEVGDYFPEFLGLLEESPFLKRTLPWGTLSSLRGMSPTKS DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSMPRTSEPREVLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCA-AESSE-PPRVTKDVVCFHAGDFPYVVQRL QLDLYEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDVYFIPRNVVHQFKTVSAVCS LAWHVRLQQYHQ-------------------KE--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE EE---------------------------------------------------------- ------------EEE--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EEVTLGRETRENEVKGRIKE-------ESEEVDVGE KRTLLADVKEERDDRPSPSQPSLS----------------------VNS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------DGLSDVRGDEEEAT---------- ----------------GRKEERKSKWD----------------------S---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------AKVKAEAPTSPPCDSKSPSP- ------------------------------------------------------------ -------------------------------KASARP-PHL------------------- --------LHS------------------------------------------------- ----DSRTV--------------------------------------------------- -----------------------------------SS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VKNVPPSPHKPSCSP--------------------- ---------------------------------PHSKSSARASPSPSAGAAFASSRSVSA TSSSA------------------------------------------------------- -----------------------AP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------CPPASSSSLTRP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------LPLSSPSARPRDPAHLRP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------DARTQAPSEARP-PPGRAAA--------DAQT-------------- ----------------------------RTVQ---------------------------- -------------------------------------AERRTH----------------- -PAA--R---------------------------TQTVSESETRT--------------- --------KH------AAQDAPPRGMYMQQY----------------------------- ---PA-Q--------------------------------------HLPQMLPPPFPPLLP -HS---------------------HEQHTLNSFLGQAG-PPHSVHLS--HLH---PPHQP SVTAQSQPYFQPPLIPPSSSSSSPQPNAPLTSSQSYSPHFSYH---HQF----AKTFFPP Q-------HPGFSSHPFLPHQSFL-P------HPLQP-QYQTSAPAQPQLHLTQSFPSP- ------------------------------------------------------------ --------------HPPPPPSAT--PPPPPPPFLP------------------------- ---------P-PPPLPQP------------------------------------------ --------------SPSIIPPPPRHDDEP------------------------------- ---K-------------------------------------------------------- --------------------------------------------------------QIL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMALP00000022140 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADSQGSVHLSG--------------------------NAATAVPSPL TSTKSPLIKQTEAKGAPD-CHSQTSRN----------------FT--QPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEER-SVKPKKLNREGGV--------G-G-------------------- -----------------------NG----------------------G-GKEKL----QQ PTK--------------QQS---------------------------------------- -----------------------------------------------------------Y -GSS-TGLWSLS------------------------------------------------ ----Q------------------------------------------------------- ------------------------------------------------------------ -------VKT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSS------------------NPPVLP-TGGLQ P-----------------------------------------------PTNTHK------ -----------------------VFKQSDFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SSSKP----------------------SKQSKDEQR--EREK-GKGCG------- ----EEEK----K-QKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LVTFGSESNINASNNN----NNI SRFNNISA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----VKRENGEVM----------------------------------------LP----- ------------------------------------------------PKVWSRS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------VGATFFFPDEEADDIHPSSLEIIILCGFIS HQNNKRRMGASTPVWTCVQDAQK---HSN--KAKESYRE--------------------- -----------------ER-EKKK----VIDRE----------------------R---E -KEKHK-V--MNEIKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-DKEKAKINSE-ELQIKKVKKKKKKKHKEGEKHK--------------------- -------------R----VKMCHRSCQTICAGLL-------------------------- ------------------------------LLPPS-SPSSSL------------------ -----------------------------TQDDSL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------Q---------------------------------FKSPLPV F----SKSSEVLPSS--PA---------------------LCSKSPFNSS---------- ------------------------------L---LRSPSSSVRTPQPSPT-KHQL----- -----------------------------------------------------------Q CTYPGMAGLEFAPYIHIENQPNGGALVAHAYTSQLSSLSMCQRQRFAQEFVSLAFSED-S SQAAHYVIGIVHGEASYLPDFLDYFSTRFPSAPVKMEILGKKDIETTTMANFYSQVKKTY THGTYRAGAMRQISLVGAVDEEVGDYFPEFLSMLEESPFLKLTLPWGGFSSLSQINPTES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFERRTTAAVGVLKAVCS-REGSE-PSRVIKDVVCFHAGDFPYVVQRL QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------GE--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -E---------------------------------------------------------- ------------VKDE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EEA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KPVELKEKETDTVEVEE K----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VEEEG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --RREK--------KGEKGV-------KERIIKE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------D-------------------------------------- ------------------------------------------------------------ -----------------------------------------------------DEVDVAE NRTLPANKKDEQDRHL--------------------------------HPQHPPLLSQPA VSFSSNESSDTDRKEERDKAKAH------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GRPK------------------ ----QQ------------------------------D----------------------- -------------------------------------------------S---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------S---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------AKLKTEPPAPPLCKNKFPPPL HQSPPASL----------------------------------------------HS---- -----------------P-----HQE-AKP-KASSKP--YH------------------- ---------HHHH----------------------------------------------- ------------------------------------------------------------ -----------------------------LDSIMTSSSTV-------------------- ------------------------------------------------------------ ----------------------------------YSSSS------SAL-SPPAGFADTP- ------------------LRL---------------------------SSTTSSVPVLST ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------P----------------------------------- -SMSTSVTSSLTSLKPAV----------------------------DSLISPL------- -SPS-------------------------------------------------------- -------------------TVSLPS----------------------------------- QLPPSSQSDQL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KD-------------------------------------------------------- -KDSL-WLKPDIQSDTRTQS--EIRT-PQESPAV--------NVQA-------------- ----------------------------HTFQADIQTHML-------------------- ------------------------------------------------------------ ---ADT-------------------------------------RTQALPEKWMHTLDSDS RVS-VDPQMC------TPQDTGRQEICMQTYTP-QHLP---------------------- ----S-P--------------------------------------HLPQMLPPSFSPLMP -HSHLSHRPPVLPPNPLSSSSL-SAQPQTLNSFLSQNS-APHPVPVSQLHLH---SPHQP NITTQSQPYYQPPLI---GSPS--QLNTPLTSSQSLPPHLQHH---HQF----AKTFFPP Q-------HPHFPSHPFLSPQPFL-SQ-LPSSYPLQP-QYQTSAIAQVQLPLSQSFP--- ------------------------------------------------------------ --------------HPPPPSSSSQSPPPAPPSTLP------------------------- ---------P-PLP-PQ------------------------------------------- ---------------PSFLSPPPQHEEEQ------------------------------- ---K-------------------------------------------------------- --------------------------------------------------------QIL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPRNP00000026133 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADSQGSVHLPGAAAAA---------------------AATTATTPVV ASVKSPHGKLAEAKGASD-NRSQSSRD----------------FN--SPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRTEER-SVKPKKLSREGRV--------G-G-------------------- -----------------------NG----------------------S-GKEKL--QQQQ PTK-------------LQQS---------------------------------------- -----------------------------------------------------------Y -GSS-PGSWSFS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------VKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSNN-----------------NAPVPATTGGSQ P------------------------------------------------ISTHK------ -----------------------VFKQSDFFLHKAPS----------------------- ------------------------------------------------------------ -------ASSNSS----------------------------------------------- ----SSSSKA----------------------KKPSKDKL----REK-GKGGG------- ----EEKK----K-HKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LVTSG-------------SNNDI SRFNSISA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----VKRENGDVT----------------------------------------LP----- ------------------------------------------------PK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------E---HTTKDKAKERERQ--------------------- -----------------ER-E-NK----VKEPE----------------------REK-E -KKKHK-V--MNEFKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-EKEKAKVNTE-ELQIKKVKKKKKKKHKEGEKHK--------------------- -------------R----VKMYHRSCQTVCAGLL-------------------------- ------------------------------LIPPS-SSSPT------------------- --------------------SSSSSSSELTHNSSL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV YPPPNNKT-----SS--PP---------------------LSSKPLFNSS---------- ------------------------------LH---NSPSASIKTPLSSPT-KHQP----- -----------------------------------------------------------Q CTYPGMAGLEFAPYIHIENQPNGGALVAHAYTSQLSSLSTEQRQRFAKEFVTLAFSED-K SQAAHFVMGIIHGEAKYLPDFLDYFSTNFPSAPVKMEILGKKDIETTTMANFYSQVKKTY CHGTYRAGAMRQISLVGAVDEEVGDYFSEFLGMLEESPFLKLTLPWGTASSLWQMSPTES DDGPIMWVRPGEQMIPVTDIPKSPFKRK-------RSTNEVKNLLQSLPRTSEPRELLFE DRTRAHADHIGQGFERETTAAVGVLKAVCS-VESSE-PPRVTKDVVCFHAGDFHYVVQRL QLDLHEPPLSQCVQWVDDAKLNQMRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSSVCS LAWHVRLQQYHK-------------------KET-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------DNVDE------------------ -----------------------------GE----------------------------- ----------------------------------------------------EKKGVKEE EE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------NLVDM KETEIVVKME--------------------------------------------EEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EEE--- -----------------------------------------VV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------EG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --RSEK--------KSEKVV-------KERIKVE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------N-------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EEVVVAD NRTLQTAKKED------------------------------------------------- ------------------------------DQL-------------QHPPPSYQPALSVD SSLNSA------------------------------------------------------ --------------GDRKEVTEKIKEH--------------------------------- ---------------RRPN----------------------------------------- -----Q------------------------------N----------------------- -------------------------------------------------S---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------AKVKTEPAAPPLCKSKS---L TQSPPASLP--------------------------------------------LH----- ------------------------QE-SKP-KASSKP--HH------------------- ---------HYHH------------------------HHH-------------------- ------------------------------------------------------------ ----------------------SGIRTM-------------------------------- ------------------------------SSSTSSSSSASHSAPKSSPSPLFSKSSASV SLGPAG----TPLNSSSAVPHPSSASSFSTVMSSFSSSS--------------------- ------------------------------------------------------------ -------------------------------------------------SKPAA------ --------------------------DSSHFMLP-------------------------- ------------------------------------------------------------ ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------SSS--S QRPPYSQSDET------------KDKGSLQLTRTQMQLGSRPSQGLL------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AV--------DFQT-------------- ----------------------------HTSQTDTRTHTA-------------------- ---------VDTQDRTITDTRI-------------------------------------- -----------------------------------------------LPETWTHCL--DS RTS-ADMQIR------PPPDTTRQGIYMQQYTP-QHLP---------------------- ----P-P--------------------------------------HLPH-FPPSFSTLLP -HSNLPHRPPGLPPNPLSNPSF-PTQPQTLNSFLSQTA-PPHSVHMSQLHM------HQP NITTQSQTYFQPP----------PQPNPPLTSSQSFPPHLSHP---HQF----AKTFYPP Q-------HPGFSPHPFLPPQSFL-SQ-PPGSYPLQP-QYQTSAPMQVQLPLSQSFP--- ------------------------------------------------------------ --------------HPPPPPSSS--PPPPPPPL--------------------------- ---------P-PLP---------------------------------------------- ---------------------PPKHDEEQ------------------------------- ---K-------------------------------------------------------- --------------------------------------------------------QIF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSKMAP00000018669 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADSQGSVYLSGAAA--------------------------------- --VKGALGNPTEAKGAPD-NRSQFPRD----------------SS--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEEKSSVRPRKLSRDGGV--------G-G-------------------- -----------------------NG----------------------G-GKEKL----QQ TSK--------------QQS---------------------------------------- -----------------------------------------------------------Y -GGS-TGLWTFS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------LKT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSS----GG------------NPPAPA-TGG-- ----------------------------------------------------HK------ -----------------------VFKQSDFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SSSKP----------------------R--SKDKQ----REK-AKGGG------- ----EEKK----K-HKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LLTSG--SNV---NNS----GDI RGFNNVSA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AKRENGEVA----------------------------------------LP----- ------------------------------------------------AQ---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------E---HPVKDKAQ-------------------------- -----------------ER-EKKK----VKERE----------------------REK-E -KKKHK-A--MNEIKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-EKDKAKINLE-ELQIKKVKKKKKKKHKEGEKHK--------------------- -------------R----VKMYHRSCQTICAGLL-------------------------- ------------------------------------------S----------------- -------------------STNSSSFSELTNNSSP------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------V---------------------------------FKSPSPF YPPPNNKDSHLRPSS--PA---------------------SASKPICNSS---------- -----------------------------ALHNSVSSPSAR----IPLPT-KSKS----- -----------------------------------------------------------Q WAYPGMVGLEFAPYIYVETQPNGGALVAHAYASQLSSLSAEQRQRFAQEFVKLAFSED-S SKAAHYVMAIVHGEAKYLPDFLDYFSTKFPSAPVKMEIIGKKDIETTTMANFYSQVKRTY SHGTYRAGAMRQVSLVGAVDEEVGDYFPEFLGLLEESPFLKRTLPWGMLSSLRDMNPTES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSLPRASEPREVLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCS-VESPE-PPRVTKDVVCFHAGDFPYVVQRL QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSAVCS LAWHVRLKRYYQ-------------------ED--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE QE---------------------------------------------------------- ------------EGEE----------------------------------------Q--- -AESKDRET---------------------------------EAAVLRKE---------- ------------------------------------------------------------ ------------------------------------------------------EEE--- -----------------EEEE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------EEEQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --QRGE--------RDERRV-------KDEMKEQ-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------G-------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EE--VAE KRMLPCVKKEE------------------------------------------------- ----------------------------------------------DEPPLSSEPALSVN S----VSNVTDK-----------DEMKN-------------------------------- ----------GAKEG--------------------------------------------- -----------------------------------------K------------------ ----HQ------------------------------D----------------------- -------------------------------------------------S---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P-------------KVKAEPPTS-LCQSKSASPL TLPP----LLAS-------------------------------------P--SLH----- ------------------------KD-SKP-KVSPKR--HH------------------- ---------HPHP------------------------HHH-------------------- --QLDSRTV--------------------------------------------------- -----------------------------------SS----------------------- ------------------------------------------------------------ ---------------------------FS------------------------------- ------------------------------------------------------------ -------------------------------PSKSSCSP--------------------- ---------------------------------PSSKSSTSAAFSP-------------- ------STGSAVISSHSSSPAAHSSSTSSPSASSSLSASSL------------------- ------SLTC--------------PR--------------------------PA------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------VSSS--S QLPPACQSEHP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KDPL-HLMPDVLSGTRTPAQSEVQT-S----------------QT-------------- ----------------------------HTAQTDTRTHLA-------------------- ---------AETRGRVLGDPR--------------------------------------- ----------------------------------------------TLLDVWTHSSSSDS RTC-MDLQMH------PPQDATRQGIYMQQYTP-QHLP---------------------- ----P-P--------------------------------------HLPQMLPPPFPPLLS -HSHLPHRPPVLPPNPLPSPSF-PPEPQTLNSFLSQTL-PPHSVHLS--HL------HQP NLTTQAQTYYPPPLLPPSS-----QPNSP---SQPLLPHLTYQ---HQF----AKTFFPP Q-------HPGFNSHPFLPPQSFL-SQPPPGSYPLQP-QYQTSPSVQAQLPMSPSFP--- ------------------------------------------------------------ --------------HPPPPPSSP--PPPPPPPL-PP------------------------ ---------P-PLP---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSBSLP00000026027 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADSMGSVHLPGAAA--------------------------TAVVPSV ASAKSATAKQTEAKGAPD-SRSQSSRD----------------FN--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRAEEK-SVKAKKLGRDGGV--------G-G-------------------- -----------------------NG----------------------G-SREKL----QQ PSKQQ------PQQQQQQQP---------------------------------------- -----------------------------------------------------------H -GAS-AAVWSFS------------------------------------------------ ----Q------------------------------------------------------- ------------------------------------------------------------ -------VKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSD------------------NAPVPA-TGGSH P-----------------------------------------------PTNTHK------ -----------------------VFKQSDFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----STSKA----------------------KKPSRDKQ----REK-GKAGG------- ----EEKM----K-HKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ALTSGPGS------------NDI GRFNNTSA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ARRENGEVT----------------------------------------LP----- ------------------------------------------------AK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------E---HSN--KAKDRDRG--------------------- -----------------EG-EKKK----VTDKE----------------------R---E -KKKHK-I--MNEIKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-EKKKAKINSE-ELQIKKVKKKKKKKHKEGEKHK--------------------- -------------R----VKMYHRSCQTICAGLP-------------------------- ------------------------------LFPPS-PPPAVS------------------ ----------------------------PTHNSPI------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV YPLPNNKTSHVLPSS--PS---------------------LAAKCHLNSS---------- ------------------------------L---LSSPPSSTKTPQPSPT-KHQP----- -----------------------------------------------------------Q GSYPGMAGLQFAQYIHIESQPNGGALVAHAYTSQLSSLSVEQRHRFAEEFVSLAFRED-S SQAAHYVMSIIHGEASYLPDFLDYFSSRFPSAPVKMEILGKKDIETTTMANFYSQVRKTY SHGTYRAGAMRQISLVGAVDEEVGNYFPEFLNMLEESPFLKRTLPWGTFSSLSQMSPSES DDGPIMWVRPGEQMIPVADVPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCS-SESPE-PSRVTKDVVCFHAGDFPYVVQRL QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSAVCS LAWHIRLKRYHH-------------------EEG----------------D--------- ------------------------------------------------------------ -----EP----------------------------AKEE--------------------- ----------------KLHE----------------L----------------------- ------------------------------------------------------------ ----------------------------------------------------------EE ED---------------------------------------------------------- ------------VEDE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------ARNEKRVERGVR------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KIKEE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------D-------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EEVDWQE GRTLLAVKKEEEDRQL--------------------------------HPQCRPLPSQPV VSV----GPDTDRKEGKERETRD------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GRPK------------------ ----QQ------------------------------DCAST------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------QAKTEPPAPPLCKNKSPS-- -----------SPLLS------SPVSLIL--------------------P----H----- ------------------------QD-MKP-KTSSRP--HH------------------- ---------HHQQ------------------------QQH--------QR---------- --QSDCRTS--------------------------------------------------- ------------------------------------------------------------ -----------------------------SSITSSSMSSNSHLAPKSS------------ ----------------------------------------------------------PS --------TLLPSAGLTDLPLCSSSAAPSL------------------TSAASSVPVRST SS---------------------------------------------------------- ------------------------------------------------------------ -----------------------------------LTSSQ-------------------- ------------------------PD--------------------------P------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SLP-----------------------TLPSSVVSLS--S QPPASTQSDQL-KDK--------------------------------------------- ------------------------------------------------------------ -----------------------QSP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------KPDVKSDTRTQS--ESQR-PQGSPAV--------DVQT-------------- ----------------------------HSSQPDVWTRSL-------------------- ---------ADAQDRALTD----------------------------------------- ------------------------------------------VRTQTLPENWTHSSDLDS RTS-MDSQTC------APHNAGRPGVYLQQYTP-QHLP---------------------- ----P-P--------------------------------------HLPQMLPPPFSPLLP -HSHLHHRPPVLPPNSLPNPSV-PVQPQSLNSW-SQNP-SPHAVHMS--HL----PPY-P NITTQSQPYYQPPLM---GSPS--PPNTPLTSSQPFPPHLPHH-----F----AKTFFPT Q-------HPHF-SHPFLPPQSFH-SH-PPNSYPLQP-QYQTSAPTQVQLPLSQPFP--- ------------------------------------------------------------ --------------HQPPPPASSQSPPPPPPPF--------------------------- --------HP-PLP-PQP------------------------------------------ --------------SPSVHPPRPTHEDGQ------------------------------- ---K-------------------------------------------------------- --------------------------------------------------------QIL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSHBUP00000004131 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MYHRSCQTICAGLL-------------------------- ------------------------------LLPPS-STSPT------------------- ---------------------SSSSPSEIKHDSSL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------L---------------------------------FKSPLPV YPPPNNKSSHLPPSS--PS-KSH------------------------------------- ---------------------------LNSLHNSLNSPLSSTTSPLSSPT-KHQP----- -----------------------------------------------------------Q CSYPGMADLEFASYIHVENQPNGGALVAHAYTSQLSSLSVDQRERFAQEFVTLVFSED-A SQAARYVMGIVHGEAKYLPDFLDYFSTKFPSAPVKMEIIGKKDIETTTMANFYSQVKKTY SHGTYRAGAMRQISLVGAVDEEVGNYFPEFLSMLEESPFLKRTLPWGTFSSLRLMSPTES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSANEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCS-VESLE-PPRVTKDVVCFHAGDFPYVVQRL QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSAVCS LAWHVRLLQYHK-------------------GEG----------------G--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE QK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------EKVELKVEETESVFEGEKEDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KKRIKDE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------D-------------------------------------- ------------------------------------------------------------ -----------------------------------------------------VEVEVAE SRTLPTGRNEE------------------------------------------------- ------------------------------------------------------------ ---------------------------DSDCLQHPPPPSRPALSAHS----------DKQ EVMERAAGERG------------------------------------------------- ----------------------------------------PK------------------ ----RQ------------------------------D----------------------- -------------------------------------------------S---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------AKVKAESPA-PACKNKSPPPR TMSPPAFLPLD------------------------------------------------- ------------------------RD-TEP-KISSKP--HH------------------- ---------HHHH----------------------------------------------- --LLDSRTT--------------------------------------------------- -----------------------------------SSS---------------------- ------------------------------------------------------------ ----------------------------------RSSSS--------------------- ------------------------------------------------------------ -----------------------------------SASPK-------------------- ---------------------------SS----P--KSSTSSAFSP-------------- ---------SPVASLHSTFAASHPSSTSSSSSSSS------------------------- --------AVVSTSS---------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------LP-----ASSSSLTSLKPAVESLLSTLPPSS------- QPLPSSKTDQP-KDKDSL----------------------------------PVTDTRTQ -----------------------------------------------------------G WS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------QGSPTV--------DVKP-------------- ------------------------------------------------HPSEINTWTYTG ID---------------------------------------------------------- ------------------------------------------MRTQTRPEAQTHTLDSDS RTS-VDLPVH------PPQDASRQGNYMQQYTP-QHLP---------------------- ----P-P--------------------------------------PLPQMLPLSFSPLLP -HSHIPHRPPGLPRNTLSCPSL-PTQPQTLNSFLTQKA-PPHSVHLSPLHLH-----HQP NITTQSQPYFQPPLM---ASPPL---SSPLTNTQSLSPHLSHP---HQF----AKTFFPT Q-------HPGFTSHPFLPPQPFL-SQ-PPGAYPLQP-QYQTSASMQVQLSLSQSFPHP- ------------------------------------------------------------ --------------PPPPPPSSS--PHPPPPPL-P------------------------- ---------P-HPP-PQP------------------------------------------ --------------RPAVFPPPPNHEEEP------------------------------- ---K-------------------------------------------------------- --------------------------------------------------------QIL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMZEP00005011111 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MYHRSCQTICAGLL-------------------------- ------------------------------LLPPS-STSPT------------------- ---------------------SSSSPSEIKHDSSL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------L---------------------------------FKSPLPV YPPPNNKSSHLPPSS--PS-KSH------------------------------------- ---------------------------LNSLHNSLNSPLSSTTSPLSSPT-KHQP----- -----------------------------------------------------------Q CSYPGMADLEFASYIHIENQPNGGALVAHAYTSQLSSLSVDQRERFAQEFVTLVFSED-A SQAARYVMGIVHGEAKYLPDFLDYFSTKFPSAPVKMEIIGKKDIETTTMANFYSQVKKTY SHGTYRAGAMRQISLVGAVDEEVGNYFPEFLSMLEESPFLKRTLPWGTFSSLRLMSPTES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSANEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCS-VESLE-PPRVTKDVVCFHAGDFPYVVQRL QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSAVCS LAWHVRLLQYHK-------------------GEG----------------G--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE QK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------EKVELKVEETESVFEGEKEDE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KKRIKDE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------D-------------------------------------- ------------------------------------------------------------ -----------------------------------------------------VEVEVAE SRTLPTGRKEE------------------------------------------------- ------------------------------------------------------------ ---------------------------DSDCLQHSPPPSQPALSAHS----------DKQ EVMERAAEERG------------------------------------------------- ----------------------------------------PK------------------ ----RQ------------------------------D----------------------- -------------------------------------------------S---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------AKVKAESPA-PACKNKSPPPR TMSPPAFLPLD------------------------------------------------- ------------------------QD-TEP-KILSKP--HH------------------- ---------HHHH----------------------------------------------- --LLDSRTT--------------------------------------------------- -----------------------------------SSS---------------------- ------------------------------------------------------------ ----------------------------------RSSSS--------------------- ------------------------------------------------------------ -----------------------------------SASPK-------------------- ---------------------------SS----P--KSSTSSAFSP-------------- ---------SPVASLHSTFAASHPSST-SSSSSSS------------------------- --------VVVSTSS---------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------LP-----ASSSSLTSLKPAVESLLSTLPPSS------- QPLPSSESDQP-KDKDSL----------------------------------PVTDTQTQ -----------------------------------------------------------G WS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------QGSPTV--------DVKT-------------- ------------------------------------------------HPSEINTWTYTG ID---------------------------------------------------------- ------------------------------------------MRTQTRPEAQTHTLDSDS RTS-VDLPVH------PPQDASRQGNYMQQYTP-QHLP---------------------- ----P-P--------------------------------------PLPQMLPLSFSPLLP -HSHIPHRPPGLPQNTLSSPSL-PTQPQTLNSFLTQKA-PPHSVHLSPLHLH-----HQP NITTQSQPYFQPPLM---ASPPL---SSPLTNTQSLSPHLSHP---HQF----AKTFFPT Q-------HPGFTSHPFLPPQPFL-SQ-PPGAYPLQP-QYQTSASMQVQLSLSQSFPYP- ------------------------------------------------------------ --------------PPPPPPSSS--PHPPPPPL-P------------------------- ---------P-HPP-PQP------------------------------------------ --------------RPAVFPPPPNHEEEP------------------------------- ---K-------------------------------------------------------- --------------------------------------------------------QIL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSATEP00000020540 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MYHRSCQTICAGLP-------------------------- ------------------------------LLRPS-PSSPS------------------- --------------------------SNPMHYSPM------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV YPPPNNKTSHVLSSS--P----------------------LASKSQLNPT---------- ------------------------------L---PNSPLSSTKTSQPPLN-KHQP----- -----------------------------------------------------------Q CTYPGMAGLEFARYIHIENQPNGGALVAHAYTSQLSSLSEEQRQRFAEEFVALAFSED-S SQAAHYVMSIVHGEASYLPDFLDYFSSRFPSAPVKMEMLGKKDIETTTMTNFYSQVKKTY SHGTYRAGAMRQISLVGAVDEEVGNYFPEFLSMLEESSFLKRTLPWGTFSSLSLMSPTES DDGPIMWVRPGEQMIPVAEVPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCS-SEGSE-PSRVTKDVVCFHAGDFSYVVQRL QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSAVCS LAWHIRLKQYHQ-------------------EEG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E ED---------------------------------------------------------- ------------VKEE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EEG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KPVELEEEEKET----- ------------------------------------------------------EE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------EKEVEG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --RKEK--------KGEKGL-------KERIKEE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------D-------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EEVDGTE NRTLPAVKKEEGNDHL--------------------------------HPHHPPLLPQPV VSVDSNKSSDTDRKEEKTRETED------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GRAT------------------ ----QQ------------------------------D----------------------- -------------------------------------------------S---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------T------------TKTKTEPPAPP-CKNKSPLPL PLAPPASF----------------------------------------------HL---- -----------------P-----HQD-TKS-KASSQP--HQ------------------- ---------HQHH----------------------------------------------- ---SDNRMV--------------------------------------------------- ------------------------------------------------------------ ------------------------------SSSSASSSSTSHLAPKSPLSPSFSKSSSSF AVAPSTGFTESPLRSSSGAPHLS------------SSASSG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------P----------------------------------- -----------------FLSTSSSLSASTTSSLS----------QLDSH----------- ------------------------------------------------------------ ---------------------------------------------LSTLPPSTVSSSSSS QLPSSSVSDQL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KD-------------------------------------------------------- -KDSL-WLKPDIQSDT-THS--ECRT-SQGSPAV--------DVQT-------------- ----------------------------HTSQAGTRTHTL-------------------- ---------GDTRDRTLAD----------------------------------------- ------------------------------------------IRTQTLPEKWTHCLNYDS RAS-TDPHMC------APQHTGKPGIYMQQYTP-QHLP---------------------- ----P-P--------------------------------------HLPQMLPPTFPSLLP -HSHLPHRSPVLPPNPLSRPSL-PAQPQSLNSFLSQNP-TPHSVHMSQPHLH---PPHQP NITTQSQPYYQPPLI---GSPS--QHNTPLTSSPSLSPHLPHH-----F----AKTFFPP Q-------HPHFSSHPFLPPQSFL-SQ-PHSSYPLQP-QYQTSAPAQVPLSLSQPFP--- ------------------------------------------------------------ --------------HPPPPPSASQSPPPPPPPL-P------------------------- ---------P-PLP-PQP------------------------------------------ --------------SPSVLSPRPKHEEKQ------------------------------- ---K-------------------------------------------------------- --------------------------------------------------------QIL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSLBEP00000038414 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADLLGSVHLTGAAA---------------------------AVAPAV ASAKSLLVKPTEAKGDPD-NRYQSSRD----------------FN--PPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KRVRVEER-SVKPKKVSTDGGV--------G-G-------------------- -----------------------NR----------------------S-VKEKL----QQ PTK--------------QQS---------------------------------------- ------------------------------------------------------------ --NS-PGSWSFS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------VKT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSNI-----------------PPPVPA-TGGSQ P-----------------------------------------------PTNTHK------ -----------------------VFKQSHFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SSSKP----------------------KKPNKDKL----REK-EKGCGD------ -------K----K-HKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LVTSGHGSSN--NNNN----NDV SRY-NTSA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----VKRENGEVM----------------------------------------LA----- ------------------------------------------------PK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------E---HS--DKVKEREQE--------------------- -----------------ER-EKKK----VK--D----------------------REK-E -KNKHK-V--INEIKRENGDVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-EKE--KINSE-ELQIKKVKKKKKKKHKEVEKHK--------------------- -------------R----VKMYHRSCQTTCAGLL-------------------------- ------------------------------LCPPS-SPPPS------------------- -------------------------------NSSL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPI FNTTNNRT-HLLPSS--PP---------------------LSSKALFSSP---------- ------------------------------LHNSP----SCIKPAQPSPT-KNHA----- -----------------------------------------------------------Q SVYPGMAGLEFAPYIHIENQPNGGALVAHAYTSQLSSLSAGQRQRFAQEFVTLSFSED-S SQAADYVMGIVHGEAGYLPDFLDYFSDHFPSAPVKMEILGKKDIETTTMANFYSQVKKTY SNGTYRAGAMRQISLVGAVDEEVGDYFPEFLNMLEESPFLKRTLPWGTRSSLRQMSPTES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVLS-GESSD-PPRVTKDVVCFHAGDFPHVVQRL QLDLYEPPLSQCVKWVDDAKLNQLRREGIRYARIRLCHNDIYFIPRNVVHQFKTVSSVCS LAWHVRLQQYHG-------------------GEG----------------E--------- ------------------------------------------------------------ -----D------------------------------------------------------ ------------------------------------------------------------ ------------------------------E----------------------------- ----------------------------------------------------EE----EE EE---------------------------------------------------------- ------------VKEE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------VELKEKESEV----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------EEER------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --RRGK--------KEEKCL-------KERIK---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EEVDVAE KRTLLTVKTEE------------------------------------------------- ----------------------------------EESLPLQPS------PLVSPPPLSMD S----------------------------------------------------------- ------------------------------------------------------------ ------------------NVSGTRDKEEEEEKKRLKEGVKPK------------------ ----QQ------------------------------D----------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------H------------AKIKAEP-------------- ----------------------------LSPLRNKSTPPPS-----ARCP---------- -----------------P-----DQD-AKP-KAASSK--HH------------------- ---------HRHH------------------------HH--------------------- --NSENRTT--------------------------------------------------- -----------------------------------SSSK--------------------- -----------------------------------SSSSFPHSASKSH----ISKS---- -----------------------------------SSSS--------LVSPLA------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------P-------------------------- ------------------------------------------------------------ ------------------------PS--------------------------PS------ -----SVSSAF------------------------------------------------- ------------------------------------------------------------ ---------------------SLPA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------TTSSSFAKSAQTIV KPSSCCRPEL-------------------------------------------------- --KD-------------------------------------------------------- -KDS---------------------------------------------PRLKADNALDT RTHKAATDVQQTHTPSGL-------------QVDTRTHTA-------------------- -D---------------------------------------------------------- ------------------------------------------VRTYTLQETWTQS--SNS RTSSLDPQ--------------RPGSYLQQYTP-KHLP---------------------- ----P-P-------------------------------------SPLPHMLPPSYP---- -----PHRPPMHPPN--------PPLPQTMNSFLPQTP-PPHSAHINQLHLP---PPPQP NLTTQSQPYYHPSLP----------------ASQTLPHLLPHH---HQY---------PP KPNPTTPSAPHFPFHPFLPPQSYL-PN--------------------------------- ------------------------------------------------------------ -------CRLLT----------------------P------------------------- ------------------------------------------------------------ -------CSHCTK----------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------L- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSORLP00000043715 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADTQGSVHLTGAVAV---------------------------VPHAV TSVKSMFGKPTEVKGAPD-YRSQPYRD----------------FT--SPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEER-SVKPKKLGRDGGV--------E-S-------------------- -----------------------DS----------------------S-GKEKL----QQ SAK--------------QQS---------------------------------------- -----------------------------------------------------------Y -AS--AGLWSFS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSG---GGG------------NPSMPG-AGGG- ---------------------------------------------------SHK------ -----------------------VFKQSDFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FSSKP----------------------K--CKDKQ----KDK-GKGGG------- ----EEKK----K-HKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------L-TSLQGSNV--ANNN----NDI SRFNNISPA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----VKRENGEVA----------------------------------------FP----- ------------------------------------------------AK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D--LHSPKDKAK-------------------------- -----------------ET-EKRK----AKEQE----------------------TEK-E -KKKHK-L--TNEIKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-EKEKAKISSE-ELQIKKVKKKKKKKHKEGEKHK--------------------- -------------R----VKMCHRSCQTICAGLL-------------------------- ------------------------------LLPGP-------L----------------- -------------------LSTNSSSSELTNRLSL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV CPLPNDK----------------------------------------------------I SHLDSYP-----------PNVSSSMK-------------------AAFPT-KPCL----- -----------------------------------------------------------Q SAYPGMAGLEFASFIHIENQPNGGALIAHAYTSQLSSLSADQRRRFAQEFVTLAFSED-T SQAAHYVMGIVHGEAKYLTDFLDYFSTKFPSVPVKMEILGKKDIETTTMSNFYTQVKRTY SHGTYRAGAMRQISLVGAVDEEVGDYFPEFLGMLEESPFLKLTLPWGTLSSLSHMCPTES DDGPIMWVRPGEQTIPVADVPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFDRQTTAAVGVLKAICP-VDRSE-PPRVTKDIVCFHAGDFPYVVQRL QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVIHQFKTVSAVCS LAWHIRLRQYHQ-------------------GEG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GAKEEPGEAGTGTFKQEEK-----------------------EEE--- -----------------------------------------GSDSKK------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------V-------KEEIKEE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VAENGMLLPRKSEELD--- ------------------------------------------------------------ ------------------------------------DQPL-------------------- ------------------------------C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PAE-----KEDLPP---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------PQGKQECAISPICKNKFRPPL ---------------TLPGLSSSPLL---------------------------------- ------------------------KE-AKP-KATSKP-PHH------------------- ------------------------------------------------------------ --YSDSGTS--------------------------------------------------- -----------------------------------SSKTPLS------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------L---------------------------PL---------------------- -------------------------------------SP--------------------- ---------------------------------PPLKSSTSAVAAPLT------------ -------------------AAPPPTSTSSPLAEK-------------------------- ------------------------P----------------------------------- --------------------SSSSLAA-----------------------CP-------- --PSET---------------------------------PPSVFCQAAPSSHPEPAQDRL LLTPAIPSDTRTAAQSEVQTLQLP------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------LPA------------------------------------------ ------------------------------------------------------------ ------------------------------------------DVQT---P---------- -------------------------------QTDTRT----------------------- -------------------------LSDADRWLPVP------------------------ --------------------------------------------------------DSDS RTS-AEVQMH-----PLPPEAGRRGIYMQQYS--QFLPPP-------------------- ---PPSP--------------------------------------HLAQMLPPSFSPLLA -PPHLPHRPPTLP-------------PQTLNSYLGQTG-PPHSVHLGALH-------PQA GITTQSQPYFTPPLM---TPSS--QPNPPLTSSQSLPPHFSYQ---HQF----AKPFFPS Q-------HPSFTSHPFLPPQSYF-PQ-PPTSYPLHS-QYQTSAPLQVQMPMSQPFAHP- ------------------------------------------------------------ --------------PPPPPPPSS---PPPPPPF-PP------------------------ ---------P-PPPLPQP------------------------------------------ --------------SPSLFPPPPRHEDEQ------------------------------- ---K-------------------------------------------------------- --------------------------------------------------------QIF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSORLP00020017221 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADTQGSVHLTGAVAV---------------------------VPHAV TSVKSMFGKPTEVKGAPD-YRSQPYRD----------------FT--SPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEER-SVKPKKLGRDGGV--------E-S-------------------- -----------------------DS----------------------S-GKEKL----QQ SAK--------------QQS---------------------------------------- -----------------------------------------------------------Y -AS--AGLWSFS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AK--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SSG---GGG------------NPSMPG-AGGG- ---------------------------------------------------SHK------ -----------------------VFKQSDFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FSSKP----------------------K--CKDKQ----KDK-GKGGG------- ----EEKK----K-HKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------L-TSLQGSNV--A-NN----NDI SRFNNISPA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----VKRENGEVA----------------------------------------FP----- ------------------------------------------------AK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D--LHSPKDKAK-------------------------- -----------------ET-EKRK----AKEQE----------------------TEK-E -KKKHK-L--TNEIKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-EKEKAKINSE-ELQIKKVKKKKKKKHKEGEKHK--------------------- -------------R----VKMCHRSCQTICAGLL-------------------------- ------------------------------LLPGP-------L----------------- -------------------LSTNSSSSELTNRLSL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV CPLPNDK----------------------------------------------------I SHLNSSP-----------PNVSSSMK-------------------AAFPT-KPCL----- -----------------------------------------------------------Q SAYPGMAGLEFASFIHIENQPNGGALIAHAYTSQLSSLSADQRRRFAQEFVTLAFSED-T SQAAHYVMGIVHGEAKYLTDFLDYFSTKFPSVPVKMEILGKKDIETTTMSNFYSQVKRTY SHGTYRAGAMRQISLVGAVDEEVGDYFPEFLGMLEESPFLKLTLPWGTLSSLSHMSPTES DDGPIMWVRPGEQTIPVADVPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFDRQTTAAVGVLKAICP-VDRSE-PPRVTKDVVCFHAGDFPYVVQRL QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVIHQFKTVSAVCS LAWHIRLRQYHQ-------------------GEG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GAKGEPGEAGTGTFKQEEK-----------------------EEE--- -----------------------------------------GNDAKK------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------I-------KEEIKEE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VAENGMLLPRKSEELD--- ------------------------------------------------------------ ------------------------------------DQLL-------------------- ------------------------------C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PTE-----KEDLPP---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------PQVKKECAISPICKNKFRPPL ---------------TLPGLSSSPLL---------------------------------- ------------------------KE-AKP-KATSKP-PHH------------------- ------------------------------------------------------------ --YSDSGTS--------------------------------------------------- -----------------------------------SSKTPLS------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------S---------------------------PL---------------------- -------------------------------------SP--------------------- ---------------------------------PPLKSSTSAVAAPLT------------ -------------------AAPLPTSTSSPLAEK-------------------------- ------------------------P----------------------------------- --------------------SSSSLAA-----------------------CP-------- --PSET---------------------------------PPSVFCQAAPSSHPEPAQDRL LLTPAILSDTQTAAQSEVQTLQLP------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------LPA------------------------------------------ ------------------------------------------------------------ ------------------------------------------DVQT---P---------- -------------------------------QTDTPT----------------------- -------------------------LSDADRWLPVP------------------------ --------------------------------------------------------DSDS QTS-AEVQMH-----PPPPEAGRRGIYMQQYS--QFLPPP-------------------- ---PPSP--------------------------------------HLSQMLPPSFSPLLA -PPHLPHRPPTLP-------------PQTLNSYLGQTG-PPHSVHLGALH-------PQA GITTQSQPYFTPPLM---TPSS--QPNPPLNSSQSLPPHFSYQ---HQF----AKPFFPS Q-------HPRFTSHPFLPPQSYF-PQ-PPTSYPLHS-QYQTSAPLQVQMPMSQPFSHP- ------------------------------------------------------------ --------------LPPPPPPSS---PPPPPPF-PP------------------------ ---------P-PPPLPQP------------------------------------------ --------------SPSLFPPPPRHEEEQ------------------------------- ---K-------------------------------------------------------- --------------------------------------------------------QIF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSORLP00015032083 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADTQGSVHLTGAVAI---------------------------VPHAV TSVKSMFGKPTEVKGAPD-YRSQPYRD----------------FT--SPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEER-SVKPKKLCRDGGV--------E-S-------------------- -----------------------DS----------------------S-GKEKL----QK SAK--------------QQS---------------------------------------- -----------------------------------------------------------Y -AS--AGLWSFS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------AKS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------S------GG------------NPSMPG-AGGG- ---------------------------------------------------SHK------ -----------------------VFKQSDFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FSSKP----------------------K--CKDKQ----KDK-GKGGG------- ----EDKK----K-HKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------L-TSLQGSNV--ANNN----NDI SRFNNISPA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----VKRENGEVA----------------------------------------FP----- ------------------------------------------------AK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D--LHSPKDKAK-------------------------- -----------------ET-EKRK----AKEQE----------------------TEK-E -KKKHK-L--TNEIKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-EKEKAKINSE-ELQIKKVKKKKKKKHKEGEKHK--------------------- -------------R----VKMCHRSCQTICAGLL-------------------------- ------------------------------LLPGP-------L----------------- -------------------LSTNSSSSELTNCLSL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV CPLPNDK----------------------------------------------------I SHLNSSP-----------PNVSSSMK-------------------AAFPT-KPCL----- -----------------------------------------------------------Q IAYPGMTGLEFASFIHIENQPNGGALIAHAYTSQLSSLSADQRRRFAQEFVTLAFSED-T SQAAHYVMGIVHGEAKYLTDFLDYFSTKFPSVPVKMEILGKKDIETTTMSNFYSQVKRTY SHGTYRAGAMRQISLVGAVDEEVGDYFPEFLGMLEESPFLKLTLPWGTLSSLSHMSPTES DDGPIMWVRPGEQTIPVADVPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFDRQTTAAVGVLKAICP-VDRSE-PPRVTKDVVCFHAGDFPYVVQRL QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVIHQFKTVSAVCS LAWHIRLRQYHQ-------------------GEG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GAKEEPGEAGTGTFKQEDK-----------------------EEE--- -----------------------------------------GNDAKK------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EE---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------I-------KEEIKEE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VAENGMLLPRKSEELD--- ------------------------------------------------------------ ------------------------------------DQPL-------------------- ------------------------------C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PAP-----KEDLPP---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------PQVKKECAISPICKNKFRPPL ---------------TLPGLSSSPLL---------------------------------- ------------------------KE-AKP-KATSKP-PHH------------------- ------------------------------------------------------------ --YSDSGTL--------------------------------------------------- -----------------------------------SSKTSLS------------------ ------------------------------------------------------------ --SP-------------------------------------------------------- ------SKS---------------------------PL---------------------- -------------------------------------SP--------------------- ---------------------------------PPLKSSTSAVAAPLT------------ -------------------AAPPPTSTSSPLAEK-------------------------- ------------------------P----------------------------------- --------------------SSSSLAA-----------------------SP-------- --PSET---------------------------------PPSVFCQAAPSSQPEPAQDRL HLTPAILSDTRTAAQSEVQTLQLP------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------LPA------------------------------------------ ------------------------------------------------------------ ------------------------------------------DVQT---P---------- -------------------------------QTDTRT----------------------- -------------------------LSDADRWLPVP------------------------ --------------------------------------------------------DSDS RTS-AEVQMH-----PPPPEAGRRGIYMQQYS--QFLPPP-------------------- ---PPSP--------------------------------------HLSQMLPPSFSPLLA -PPHLPHRPPTLP-------------PQTLNSYLGQTG-PPHSVHLGALH-------PQA GITTQSQPYFTPPLM---TPSS--QPTPPLTSSQSLPPHFSFQ---HQF----AKPFFPS Q-------HPSFTSHPFLPPQSYF-PQ-PPTSYPLHS-QYQTSAPLQVQMPMSQPFAHP- ------------------------------------------------------------ --------------PPPPPPPSS---PPPPPPF-PP------------------------ ---------P-PPPLPQP------------------------------------------ --------------SPSLFPPPPQHEEEQ------------------------------- ---K-------------------------------------------------------- --------------------------------------------------------QIF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSOMEP00000009127 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADTQGSVHLTGAVAV---------------------------VPHAV TSVKNMLGKPAEVKGAPD-YRSQPPRD----------------FN--SPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRVEER-NVKPKKL----GV--------ESS-------------------- -----------------------DA----------------------S-GKEKL----QP SAK--------------QQS---------------------------------------- -----------------------------------------------------------Y -GG--AGVWSFS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------VKT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------G------GGG--------SSNNPPTPA-AGGG- ---------------------------------------------------SHK------ -----------------------VFKQSDFFLHKAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SSSKP----------------------K--CKDKQ----KDK-GKGGG------- ----EEKK----K-HKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------L-TSIQGSNV--T-NN----NDI SRFNNISP---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----VKRENGEVT----------------------------------------FT----- ------------------------------------------------AK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------E---HSPKDKTK-------------------------- -----------------EA-EKKK----AKEQE----------------------REK-E -KKKHK-L--TNEIKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----E-EKEKAKINSE-ELQIKKVKKKKKKKHKEGEKHK--------------------- -------------R----VKMCHRSCQTICAGLL-------------------------- ------------------------------LLPGP-------L----------------- -------------------LTTNSSSSELTNS-SL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV YPVPNEKNS--------PS------------------------KSLFNSSPPNTSPVKV- ----------------------------------------------AFPT-KPRP----- -----------------------------------------------------------Q SAYPGMAGLEFASFIHIENQPNGGALIAHAYTSQLSSLSADQRRRFAQEFVTLAFSED-T SQAAHYVMGIVHGEAKYLTDFLDYFSTKFPSVPVKMEILGKKDIETTTMSNFYSQVKRTY SHGTYRAGAMRQISLVGAVDEEVGDYFPEFLGMLEESPFLKLTLPWGTLSSLSHMSPTES DDGPIMWVRPGEQMIPVADVPKSPFKRK-------RSTNEVKNLLQSLPRTSEPREMLFE DRTRAHADHIGQGFDRQTTAAVGVLKAVCP-VDRLE-PPRVTKDVVCFHAGDFPYVVQRL QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDVYFIPRNVIHQFKTVSAVCS LAWHVRLRQYHQ-------------------GEG----------------E--------- ------------------------------------------------------------ -----P------------------------------------------------------ ------------------------------------------------------------ ------------------------------ER---------------------------- -----------------------------------EVKGESEAGTGTVKQEVEE----EE EA---------------------------------------------------------- ------------AKKE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------EEVKEE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VAENGMSLPPQA------- ------------------------------------------------------------ ------------------------------------DQPL-------------------- ------------------------------C----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------S---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PAE-------KDLPQVKTECVTPPVCKNKSRLPL ---------------TLPGLSYSPLH---------------------------------- ------------------------QD-PNP-KASSQP-PQH------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PSG---------------------------SRTSSS------------------KPS FCSASKS----------------------------------------------------- ------------------------------------------------------------ -------------------------------------SSTSAAAAPSA------------ -------------------AAPPPSSTSSPSAEQ-------------------------- ------------------------P----------------------------------- --------------------SSSS---------------------------P-------- --PSETL-----------------PYASSRPEPPKDHVHP-------------------- --TPAVPSDARTAPQSEVRT--LP------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PPA------------------------------------------ ------------------------------------------------------------ ------------------------------------------DAQT---P---------- -------------------------------QTDTRT----------------------- -------------------------L--PDRW--AP------------------------ --------------------------------------------------------DSDS RTS-AEVQMHPP---PPPPDTGRRGLYMQQYS--QLLPPP-------------------- ---PP-P--------------------------------------HLSQMLPPSFSPLLA -PPHLPHRPPSLP-------------PQTLNSYLGQTG-PPHSVHL-------------A GVTTQSPPYFQPPL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCSEP00000014719 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADSPDSAHPTGATADTV----------------------------AV SSSKSPLVKP---------SRSQSSGD----------------FN--LPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ ------------------------------------------------------------ -------KKVRMEEK-GMKPKKVCRDRGV--------G---------------------- -----------------------------------G-----------S-GKDKL----KQ PAK--------------QQS---------------------------------------- -----------------------------------------------------------S SGSSLAAVWSFS------------------------------------------------ ----P------------------------------------------------------- ------------------------------------------------------------ -------VKA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------HLPGPQTPT---K------ -----------------------VFKQADISLQKTASP---------------------- ------------------------------------------------------------ ---TFCSL---------------------------------------------------- ---------------------------------KPSRD---GKPREKKVKGGG------- ----EEKN----K-RKL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VFSSTVETDI--SNNN-NNNKDI REFQDISA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----VKRDNGEVT----------------------------------------PL----- ------------------------------------------------PK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------E---HFTKDKAKERERD--------------------- -----------------ERGEKKK----VKDRE----------------------KEK-E -KKKHK-V--MNEIKRENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-AKEKAKINLE-ELQIKKVKKKKKKKHKEGEKHK--------------------- -------------R----VKMYHRSCQTICAGLL-------------------------- ------------------------------L--PH-NATPA------------------- ---------------------SSSPATDHMNNSTL------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKTPLPV YSSVNNKTSH---TSFLPA---------------------LTSKSLFNSS---------- ------PHANPDALSSPSP--------------------SPTKAALLSPT-KLHP----- -----------------------------------------------------------Q GSYPGMAGLEFASYIHIENQPNGGALVAHAHTSQLSTLSASQRQRFAQEFVTLVFSED-S SQAAHYVMGIVHGDASYLPDFLDYFSSKFPAAPVKMEILGKKDIETTTMAHFYSQVKKTY SHGTYRAGAMRQISLVGAVDEEVGSYFPEFLGMLEESPFLKRTLPWGTLSSLSHMSPTES DDGPIMWVRPGEQMIPVADIPKSPFKRR-------RSTNEVKNLMQSLPRTSEPREMMFE DRTRAHADHIGQGFERTTTAAVGVLKAVCG--DGSK-PARVTKDVVCFHAGDFNYVVQRL QLDLYEPPLSQCVQWVDDAKLNLMRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSAVCS LAWHVRLKQYLQ-------------------EDG----------------Q--------- ------------------------------------------------------------ -----KE----------------------------GQ----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KEE EE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EEK--- --------------------------------------------------------QNQ- --------------------KEM-------------IVEMKEE----------------- ------------------------------------------------------------ ------------------------------------------------------------ --EDTE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------IEMIDVV-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QK---------------------------- -----------EEVRRDRK----------------------------------------- -----------------------VKKEVV------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------RVKAE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------E-------------------------------------- ------------------------------------------------------------ -----------------------------------------------------EEMDLAE N----------------------GMFSDVK----------KVEQDPV------------- ------------------------TP------------------QPLHPPLVPQPVLSVD L----------KVKSTAKKEKEEDK-----C----------------------------- ---------GGVK----------------------------------------------- -------------------------------------GGIQK------------------ ----QQ------------------------------G----------------------- -------------------------------------------------S---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------AKTKTQLSSPPP--------- --PPPASK--------------------------------TKSTLLSRTPPVSQH----- ------------------------QD-TKP-KASLKL--HH------------------- ---------HHHH----------------------------------------------- ---SESRKTTS-------------------------RTLF-------------------- -----------------------------------SSSSSLSSSLFHSDRKSPSS----- SSAKLPSSVAPTASSTLSVSSPPSTSVRLTSSSVSSSSS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------TTSPK-------------------- ---------------------------SR----P-------------------------V TS---------------------------------------------------------- ------------------------P----------------------------------- ---------------------------------------------------PFTAFSSSH LSPS-------------------------------------------------------- ------------------------------------------------------------ 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---IPP---P-PPP-PQP------------------------------------------ --------------SPSGFS--QRHEENR------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSGWIP00000046491 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------ADTQGSVQ-----------------------------PGATAAAAAF TSSKPSLSKPAEAKTAPD-NRSQSSQD----------------LT-PPPP---------- --------------------------------------------------P--------- ------------------------------------------------------------ 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-----------------EP-QKKK----VKDRE----------------------KEK-E KKKKYK-V--INEMERENGEVKQPIK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----D-EKGKTQINPE-ELQIKKVKKKKKKKHKEGEKHR--------------------- -------------H----VKMYHRSCQTVCAGLH-------------------------- ------------------------------RLQAP-ASSPT------------------- ---------------------SSTPSSQLALNS--------------------------- --------------------------------------------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------P---------------------------------FKSPLPV YSPSNKSPHHALPTS--PP--------LTSQNKLGVFSL--------------------- -------------------------------------------------T-KPRP----- -----------------------------------------------------------Q CAYPGMARLEFAPYIHIENQPNGGALVAHAYTSQLAALSADQKQRFAQEFVTLSFSED-S SQAAHYVMGIIHGEACYLPDFLDYFSTKFSSAPVKMEILGKKDIETTTMANFYSQVKRTY SHGTYRAGAMRQISLVGAVDEEVGDYFPEFLSLLEESPFLERTLPWGTFSSLKHISPTES DDGPIMWVRPGEQMIPVADIPKSPFKRK-------RSTNEVKNLLQSLPRTSEPRELLFE DRTRAHADHIGQGFERQTTAAVGVLKAVCA-VKSSQ-PPRVTKDVVCFHAGDFPYVVQRL QLDLYEPPLSQCVQWVDDAKLNQLRREGIRYARIRLCHDDIYFIPRNVVHQFKTVSAVCS LAWHVRLQQYHQ-------------------AEP----------------Q--------- ------------------------------------------------------------ -----E------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE EE---------------------------------------------------------- ------------EEEE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EEE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------EEE--- --------------------------------------------------------EEEL VLKNKKMEPVVLEEDSETFKKEMKKEEVELDQIRILTLSVKEE----------------- ------------------------------------------------------------ ------------------------------------------------------------ --EDE------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------KP---------------------------------- -----------------------------------PPSSSPPSSSSSLPSFSIDSSRVKE EVKE------------TRET---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------S---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------AQVKVETP-----------PL TLATPTSLPLH-------------------------------------------H----- 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------------------------------------------------------------ ------------------------------------------------------------ --SD-------------------------------------------------------- -KDYLKRLKTDVLSDTRTWPPLEVRP-SQRPPPV--------DIHQ-------------- RT--------------------------HASPTHTRAHTA-------------------- ------------------------------------------------------------ ---VDSR-----------------------------------ARTQTHPESWTHT----- -----------PDFHIHPQDIPRQGMYLQQYAP--------------------------- ---PP-P--------------------------------------RLPHMLPP------- ----------LLPPSP--APSL--------------------------------PPPPQP ---------------------------------------------VHKLS---------P QLF----------------------PQ--------------------------------- ----------------------------------------SDSA---------------- -------------------PSSADSPEP-------------------------------- --------AS-PAP-PTP------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----A >ENSFDAP00000007566 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------S---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DV---------------------------GEEA-----A ECGLGDH----------------------------------------------------- GKDYGA-----------------------KNSDAKRCDPRV-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVE KTLQRLDTLEFRQLIHVEHQPNGGASVVHAYSSELSHLSPGEMQRFAEEFVGLVFSEN-E SSAAFYVMGIVHGAATYLPDLLDYFSFNFPNSPVKMEIMGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPN-QPRITKDVICFHAEDFLEIVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDVTQST--------------------- -----ATH---------------------------------------------------- -----ET-GALPDSTSVILAPQKDSVICAVR----------------------------- ------KTSLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PNASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNI NIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------S---------- ----NNMDEKNSKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HAQFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NFENNN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KE--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SVH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCAFP00000006414 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNAE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILSDNVKDYSGKNLD-NKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENNEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPA-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEEIAQNT--------------------- -----DTH---------------------------------------------------- -----ET-GTSPDSTSSILRSHTDHMICAVS----------------------------- ------KTSLDSNFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KSELQQM KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDGKNAKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSVVUP00000026526 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPG---------- --------------------------------------------------PVHGAPA--- ------------------------------AAAAAAAAEKEPFGKLQPPFRDP------- ------------------------------------------------------------ -PGPLSAKKVRTEEK--KAPRRLNGEGGS--------G-G-------------------- -----------------------SS------------------------------RQLQP L--------AAP----SPQG---------------------------------------- -----------------------------------------------------------Y -GS--PAPWGFP-------APPAAPSP-PSARGTFSFSAGAAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------APSPQPVPR------ -------RLLVPPPPLRAQPPHLALP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AA-----AKP----------------------RRPKEKRDKE----R------------- -----------RR-H-----GLGGAGEAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ARAENGEVK-------PLXE------------------------------------ ---------------------------------------------GRAPR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNAE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILSDNVKDYSGKNLD-NKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENNEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPA-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEEIAQNT--------------------- -----DTH---------------------------------------------------- -----ET-GTSPDTTSSILGSHTDHMICAVS----------------------------- ------KTPLDSNFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KSELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDGKNAKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSNVIP00000000006 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AD--------------------------------------------- -----------------------------------------------SPS---------- --------------------------------------------------PVDGAAP--- ------------------------------AAAAAVASEKEPFGKLQPSFRDP------- ------------------------------------------------------------ -PGPLSAKKVRTEEK--KAPRRLNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP L--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFP-------GLSAVPSS-SSARSSFSFSAGSAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASSSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAASSANAKP----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAGEA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNAE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDNIKDYSGKSLD-SKNY---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMKRFAEEFVDLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPA-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEETAQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSPESTSSVLGPHTDHVVCAVS----------------------------- ------KTSLDSNFSDRLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KSELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASIRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDK-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMPUP00000018167 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AD--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVDGAAA--- ------------------------------AAAAAVASEKEPFGKLQPSFRDP------- ------------------------------------------------------------ -PGPLSAKKVRTEEK--KAPRRLNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP L--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFP-------GLSAVPSS-SSARSSFSFSAGSAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASSSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAASSANAKP----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAGGA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AREENGDVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TGGKEKPKTNAD-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDNIKDYSGKSLD-SKNY---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMKRFAEEFVDLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPA-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEETAQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSPESTSSVLGPHTDHVVCAVS----------------------------- ------KTSLDSNFSDRLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KSELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDK-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLLSLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSAMEP00000013510 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------PC---------- --------------------------------------------------PVHGAAA--- ------------------------------AAAAAV-SEKEPFGKLQPPFRDP------- ------------------------------------------------------------ -PGPLSAKKVRTEEK--KAPRRLNGE-------------G-------------------- -----------------------NS------------------------------RQLQP L--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PTSWSFP-------GLSAAPSP-SSARSSFSFSAGSAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASSSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAASSANAKP----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAGEAGGAXX--------------------------- -----------XX----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------XXX---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------XXX--------------------------- ------------------------------------------------------------ --XLS------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNAE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDNVKDYSGKSLD-NKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVDLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPA-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEETAQTT--------------------- -----ATH---------------------------------------------------- -----ET-GTSPDSTSSGLGPHTDHVICAVS----------------------------- ------ETSLDSNFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KSELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------S---------------- ------------------------------------------------------------ ---------------------------------------------------------VNA YIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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--------------------------------------SNQERK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------VLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSUMAP00000018991 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---KHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNAE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDNIKDYSGKSLD-NKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVDLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPA-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEETAQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSPGSTSSGLGPHTDHVICAVS----------------------------- ------ETSLDSNFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KSELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------S---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------VLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSUAMP00000006720 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHG--A--- ------------------------------AAAAAV-SEKEPFGKLQPPFRDP------- ------------------------------------------------------------ -PGPLSAKKVRTEER--KAPRRLNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP L--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFP-------GLSAAPSP-SSARSSFSFSAGSAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASSSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAASSANAKP----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAGEAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AREENGEVK-------PL-------------------------------------- ------------------------------------------------SR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERD------------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNAE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDNIKDYSGKSLD-NKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVDLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPA-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEETAQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSPGSTSSGLGPHTDHVICAVS----------------------------- ------ETSLDSNFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KSELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------S---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFGNSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------VLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPTIP00000010187 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDNVKDYSGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQ----- -HGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPA-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHL-------------------EEDTVQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSPDTTSSVLGPHTDHMLCAIS----------------------------- ------KTSLDSNFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KSELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIPSVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- -----NMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENTN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSHISLV-- ----DTR----------------------------------------------------- ----------------------------------QP----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPPRP00000022958 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHG------ --------------------------------AAAAVSEKEPFGKLQPPFRDP------- ------------------------------------------------------------ -PGPLSAKKVRTEEK--KAPRRLNGEGSS--------G-G-------------------- -----------------------NS------------------------------RQLQP L--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFP-------GLSAAPSP-SSARSSFSFSAG-AV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASSSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AATSSANAKP----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAGEASGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERD------------------------KER-E -KKKHK-V--MNEIKKENGEIKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNAE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDNVKDYSGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQ----- -HGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPA-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHL-------------------EEDTVQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSPDTTSSVLGPHTDHMLCAIS----------------------------- ------KTSLDSNFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KSELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIPSVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- -----NMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENTN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSHISLV-- ----DTR----------------------------------------------------- ----------------------------------QP----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSBBBP00000003433 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPSLMQ------- ------------------------------------------------GTP--------- ----------------------------------AAVSEKESFGKLQAPSRDP------- ------------------------------------------------------------ -PGPLSAKKIRTEEK--KAPRRLNGEGAS--------S-G-------------------- -----------------------NS------------------------------RQLQS P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PGSWSFA-------ALSAAPSP-SSARSNFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSVS---------------ASSSQPVPR------ -------KLLVPPTLLHAQPHHLLVP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAAASASAKP----------------------RRPKEKREKE----R------------- -----------RR-H-----GL-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------VHERKLYNVLK----------------- ---------------------------------------------------------YLF CLL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTSVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEARGILNDTIKDYSGKSLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLRRLDTLRFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVDLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDPAQNT--------------------- -----VTH---------------------------------------------------- -----ET-GTSPDSTSSVLGPHTDSTICAVS----------------------------- ------KTSLDSIFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTGA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDSKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KVEV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------STR--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQERK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSBIXP00005022700 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPSLMQ------- ------------------------------------------------GTP--------- ----------------------------------AAVSEKESFGKLQAPSRDP------- ------------------------------------------------------------ -PGPLSAKKIRTEEK--KAPRRLNGEGAS--------S-G-------------------- -----------------------NS------------------------------RQLQS P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PGSWSFA-------ALSAAPSP-SSARSNFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSVS---------------ASSSQPVPR------ -------KLLVPPTLLHAQPHHLLVP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAAASASAKP----------------------RRPKEKREKE----R------------- -----------RR-H-----GL-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------VHERKLYNVLK----------------- ---------------------------------------------------------YLF CLL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTSVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEARGILNDTIKDYSGKSLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLRRLDTLRFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVDLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDPAQNT--------------------- -----VTH---------------------------------------------------- -----ET-GTSPDSTSSVLGPHTDSTICAVS----------------------------- ------KTSLDSIFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTGA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDSKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KVEV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------STR--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQERK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSBTAP00000020914 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPSLMQ------- ------------------------------------------------GTP--------- ----------------------------------AAVSEKESFGKLQAPSRDP------- ------------------------------------------------------------ -PGPLSAKKIRTEEK--KAPRRLNGEGAS--------S-G-------------------- -----------------------NS------------------------------RQLQS P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PGSWSFA-------ALSAAPSP-SSARSNFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSVS---------------ASSSQPVPR------ -------KLLVPPTLLHAQPHHLLVP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAAASASAKP----------------------RRPKEKREKE----R------------- -----------RR-H-----GL-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------VHERKLYNVLK----------------- ---------------------------------------------------------YLF CLL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTSVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEARGILNDTIKDYSGKSLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLRRLDTLRFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVDLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDPAQNT--------------------- -----VTH---------------------------------------------------- -----ET-GTSPDSTSSVLGPHTDSTICAVS----------------------------- ------KTSLDSIFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQV KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTGA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDSKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KVEV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------STR--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQERK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSBIXP00000025677 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPSLMQ------- ------------------------------------------------GTP--------- ----------------------------------AAVSEKESFGKLQAPSRDP------- ------------------------------------------------------------ -PGPLSAKKIRTEEK--KAPRRLNGEGAS--------S-G-------------------- -----------------------NS------------------------------RQLQS P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PGSWSFA-------ALSAAPSP-SSARSNFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSVS---------------ASSSQPVPR------ -------KLLVPPTLLHAQPHHLLVP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAAASASAKP----------------------RRPKEKREKE----R------------- -----------RR-H-----GL-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------VHERKLYNVLK----------------- ---------------------------------------------------------YLF CLL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTSVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEARGILNDTIKDYSGKSLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLRRLDTLRFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVDLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTQSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDPAQNT--------------------- -----VTH---------------------------------------------------- -----ET-GTSPDSTSSVLGPHTDSTICAVS----------------------------- ------KTSLDSIFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQV KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTGA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDSKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KVEV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------STR--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQERK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSBMUP00000014850 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPSLMQ------- ------------------------------------------------GTP--------- ----------------------------------AAVSEKESFGKLQAPSRDP------- ------------------------------------------------------------ -PGPLSAKKIRTEEK--KAPRRLNGEGAS--------S-G-------------------- -----------------------NS------------------------------RQLQS P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PGSWSFA-------ALSAAPSP-SSARSNFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSVS---------------ASSSQPVPR------ -------KLLVPPTLLHAQPHHLLVP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAAASASAKP----------------------RRPKEKREKE----R------------- -----------RR-H-----GL-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------VHERKLYNVLK----------------- ---------------------------------------------------------YLF CLL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTSVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEARGILNDTIKDYSGKSLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLRRLDTLRFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVDLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDPAQNT--------------------- -----VTH---------------------------------------------------- -----ET-GTSPDSTSSVLGPHTDSTICAVS----------------------------- ------KTSLDSIFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTGA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDSKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KVEV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------STC--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQERK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSVPAP00000009447 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KI--------------K-DKIK----ERDKD----------------------KER-E -KKKHK-V--VNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDNIKDYSGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSSEISHLSPVEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQ----- -HGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDAAQNT--------------------- -----VTH---------------------------------------------------- -----ET-GTSPDSPSSVLGHHSDSMICAVS----------------------------- ------KTSLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTGA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------S---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLINLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------STH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------VLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSRROP00000032045 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------AVHCVAA--- ------------------------------VAPTATVSEKEPFGKLQPSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFA-------PLSAAPSP-SSSRSSFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHH-LLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A AAAASANAKS----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAREAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNELKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNME-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEDQETKGILNDNIKDYVGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------T----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSSDSTSSVLGPDTNNMICAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DIR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMLEP00000011664 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHCVAA--- ------------------------------AAPTATVSEKEPFGKLQPSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--SASWSFA-------PLSAAPSP-SSSRSSFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AA AAAASANAKS----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAREAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYNKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEDQETKGILNDNIKDYVGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSSDSTSSVLGPDTDNMVCAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------AE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VTV NIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DIR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMFAP00000037843 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHCVAA--- ------------------------------SAPTATVSEKEPFGKLQPSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------SAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--SASWSFA-------PLSAAPSP-SSSRSSFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A AAAASANAKS----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAREAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYNKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEDQETKGILNDNIKDYVGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSSDSTSSVLGPDTDNMVCAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NVPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DIR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCATP00000030921 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------AVHCVAA--- ------------------------------AAPTATVSEKEPFGKLQPSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--SASWSFA-------PLSAAPSP-SSSRSSFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A AAAASANAKS----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAREAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYNKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEDQETKGILNDNIKDYVGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSSDSTSSVLGPDTDNMVCAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DIR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPANP00000011029 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHCVAA--- ------------------------------AAPTATVSEKEPFGKLQPSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--SASWSFA-------PLSAAPSP-SSSRSSFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A AAAASANAKS----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAREAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYNKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEDQETKGILNDNIKDYVGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSSDSTSSVLGPDTDNMVCAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DIR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMMUP00000011796 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHCVAA--- ------------------------------SAPTATVSEKEPFGKLQPSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------SAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--SASWSFA-------PLSAAPSP-SSSRSSFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A AAAASANAKS----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAREAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E --KKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYNKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEDQETKGILNDNIKDYVGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSSDSTSSVLGPDTDNMVCAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NVPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DIR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSTGEP00000010905 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHCVAA--- ------------------------------TAPTATVSEKEPFGKLQPSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--SASWSFA-------PLSAAPSP-SSSRSSFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A AAAASANAKS----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAREAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYNKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEDQETKGILNDNIKDYVGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSPLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSSDSTSSVLGPDTDNMVCAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DIR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCSAP00000008011 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHCVAA--- ------------------------------AAPTATVSEKEPFGKLQPSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFA-------PLSAAPSP-SSSRSSFSFSAAAAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A AAAASANAKS----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAREAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYNKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEDQETKGILNDNIKDYVGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRKR-----NRTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSSDSTSSVLGPDTDNMVCAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DIR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCANP00000031821 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEDQETKGILNDNIKDYVGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QARITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSSDSTSSVLGPDTDNMICAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DIR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPTEP00000022314 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------AVHCVAA--- ------------------------------AAPTATVSEKEPFGKLQPSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTGEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFA-------PLSAAPSP-SSSRSSFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AA AAAASANAKS----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAREAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNELKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNME-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICLGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEDQQTKGILNDNIKDYVGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHTEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----TTH---------------------------------------------------- -----ET-GTSSDSTSSVLGPDTDNMICAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DIR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSP00000334040 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHCVAA--- ------------------------------AAPTATVSEKEPFGKLQLSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFA-------PLSAAPSP-SSSRSSFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AA AAAASANAKS----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAREAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEDQAAKGILNDNIKDYVGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSSDSTSSVLGPHTDNMICAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTTA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFAEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPTRP00000033073 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHCVAA--- ------------------------------AAPTATVSEKEPFGKLQLSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFA-------PLSAAPSP-SSSRSSFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AA AAAASANAKS----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAREAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEDQAAKGILNDNIKDYVGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-G-----TSSVLGPHTDNMICAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTTA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPPAP00000013171 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHCVAA--- ------------------------------AAPTATVSEKEPFGKLQLSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFA-------PLSAAPSP-SSSRSSFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AA AAAASANAKS----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAREAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEDQAAKGILNDNIKDYVGKNLD-TKNC---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-G-----TSSVLGPHTDNMICAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTTA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DRR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSGGOP00000006904 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHCVAA--- ------------------------------AAPTATVSEKEPFGKLQLSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFA-------PLSAAPSP-SSSRGSFSFSADTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLPA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AAAA AAAASANAKS----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAREAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEDQAAKGILNDNIKDYAGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSSDSTSSVLGPHTDNMICAVS----------------------------- ------KASLDSVFPDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTTA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSNLEP00000011644 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHCVAA--- ------------------------------AAPTATVSEKEPFGKLQPSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFA-------PLSAAPSP-SSSRSSFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPPHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------AA AAAASANAKS----------------------RRPKEKREKE----R------------- -----------RK-H-----GLGGAREAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTSIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEDQAAKGILNDNIKDYVGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQNRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSSDSTSSVLGPHTDNMICAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQV KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLA-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPPYP00000020027 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PLHCVAA--- ------------------------------AAPTATVSEKEPFGKLQPSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFA-------PLSAAPSS-FSSRSSFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLPA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AAAA AAAASANAKS----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGEAREAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SREENGEVK-------QL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------T--------------- ---------------------DVEGQAAKGILNDNIKDYVGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDSLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSSDSTSSVLGLHTD-MICAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCJAP00000011363 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHGVAA--- ------------------------------AAPTATVSEKEPFGKLQPSSRDH------- ------------------------------------------------------------ -PGPLSTKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------ATP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFA-------ALSAAPSP-SSSRSSFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAAASANAKS----------------------RRPKEKREKE----K------------- -----------RR-H-----GLGGVGEAGGT----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------I--------------- ---------------------DVEDQEAKGILNDNMKDYIGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELAHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLQSRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEDTSQNI--------------------- -----ATP---------------------------------------------------- -----ET-ATSSDSTSSVLGPHADNIICAVS----------------------------- ------KASLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VIV TIPEKSRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------V---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGNL-SLV-- ----DTR----------------------------------------------------- ----------------------------------PH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSSSCP00000043199 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPSTVHGAPA--- ----------------------------------------------ATA----------- ------------------------------------VSEKEPFGKLQLPPRDP------- ------------------------------------------------------------ -SGPLSAKKIRTEEK--KTPRRLNGEGSS--------G-G-------------------- -----------------------NS------------------------------RLLQS P--------ATP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--SGSWSFA-------ALSAVPTP-SSSRSNFSFSSGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASSSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAASSANAKP----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGAGEAGGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AREENGEMK-------PL-------------------------------------- ------------------------------------------------QR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDNIRDYSGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSFKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLRKLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDTAQNT--------------------- -----VMH---------------------------------------------------- -----ET-DTLPDSKSSILGPHADNVICAVS----------------------------- ------KTSLDSIFPDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SVASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV CIPEKTGA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NSMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HIQFTEL KINV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFDSSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKGELCPRNLISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------STH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPCOP00000022652 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PRS---------- --------------------------------------------------PVRGAAV--- ------------------------------AAAAAVASEKEPFVMRQPSSRDA------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--SASWSFS-------ALSAAPSP-SSSRSSFSFSVGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAASSANAKS----------------------RRPKEKREKE----K------------- -----------RK-H-----GLG---EASGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AREENGEVK-------QP-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MTEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDNIKDYIGKNLD-TKHY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQ----- -HGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLENSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSPDSTSSVLGPHTD-MICAVR----------------------------- ------KCSLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PTASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ -----------------------------------------------------------V TIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNTDGKNVKTKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIHM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -QD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LREELCPGSLISLV-- ----DSR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PNQDRKD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMICP00000044334 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVRG------ ------------------------------AAAAAAASEKEPFVKLQPSSRDV------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KTPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFS-------ALSAAPSP-CSSRSSFSFSVGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAASSANAKT----------------------RRPKEKREKE----K------------- -----------RR-H-----GLG---EASGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----VREENGEVK-------QP-------------------------------------- ------------------------------------------------AR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILSDNIKDYIGKNLD-TKHY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQ----- -HGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLENSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSLDSTSSVLGLHTDNMICAVR----------------------------- ------KSSLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KYE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PTASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNTDGKNVKTKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIHM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LREELCPGSLISLV-- ----DSR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSTSYP00000012718 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS-----PA--- ------RGVAAA-------------------AAVSEKEQYGKPQSSC------------- --------------------------------------------------RDP------- ------------------------------------------------------------ -PASLSAKKVRAEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GC--PASWSFA-------ALSAAPSA-SSSRSTCSFSAGEAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSAPVPR------ -------KLLVPPTLLHAQP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------PRLLLRRRD--- --HRSPAGRGCGGQKRPLY----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SN------------------------------------- --KI--------------K-DKIK----ERDKE----------------------K---E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDNIKDYSGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------DNSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLRRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLEYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPN-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-DTSTNSTSSVLGQHTDNMICAVS----------------------------- ------KGSLDSVFSNKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYALQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASLRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSSTOP00000013672 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHG-AA--- ------------------------------AASASVVSEKEPFGKLQSSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQP P--------VAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWSFS-------ALSATPSP-SSSRSCFSFSAGSAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAASSANAKP----------------------RRPKEKREKE----K------------- -----------RR-H-----GL------GGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- -----------GG----LFCL--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SD------------------------------------- --KI--------------R-DKIK----ERDKE----------------------KER-E -KKKHK-V--MSEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKQKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDNLKDYIGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NILKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-ATSPDSISSVLGPHTDNMICAVS----------------------------- ------KTSLDSVFSEKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KHELSQF KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVSSVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NISEKTKA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVRFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KE--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QL----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMMMP00000019948 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHG-AA--- ------------------------------AASASVVSEKEPFGKLQSSSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NS------------------------------RQLQ- -----------------PQS---------------------------------------- -----------------------------------------------------------Y -GS--PASWNFS-------ALSATPSP-SSSRSCFSFSAGSAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASLSQPVPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAASSANAKP----------------------RRPKEKREKE----K------------- -----------RR-H-----GL------GGA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AREENGEVK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MSEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKQKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDNLKDYIGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NILKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-ATSPDSISSVLGPHTDN----------------------------------- ------KTSLDSVFSEKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KHELSQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVSSVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NISEKTKA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------S---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVRFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KE--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QL----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSTBEP00000004866 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVHGAAA--- ------------------------------A---AAVSEKEPFGKLQACSRDP------- ------------------------------------------------------------ -PGSLSAKKVRTEEK--KAPRRVNGEGG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------XXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDNVKDYIGKTLD-TKNC---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLKFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY -HGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDASQNT--------------------- -----AIH---------------------------------------------------- -----EA-GRSPDSTSSALGHHTEKMICAVS----------------------------- ------KDSLDSVLSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PISSVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NVPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDGKNIKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------RVQFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -TD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLLNVV-- ----DTR----------------------------------------------------- ----------------------------------QH----D------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMLUP00000014246 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-EKIK----ERDKE----------------------KER-E -KKKHK-I--MNEIKKENGEVKMLLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------H----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------D-EDQEAKGILNDNIKDYGGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------GSKL-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLRRLDTLEFKQLIHIEHQPNGGASVIHAYSNELTHLSPVEMARFAEEFVGLVFSEN-E NSAAFYVMGIVHGAAAYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDTAQNT--------------------- -----DTH---------------------------------------------------- -----EM-GTSPGSTSSVLGPHSDDRICAVS----------------------------- ------KTSLESIFSDTLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYEVQQI KQE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASVRIN-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------S---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YVSEETRT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDVKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIEV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------TFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPESLLSLV-- ----HTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SVH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SHQNRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSECAP00000001942 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPG---------- --------------------------------------------------PAHGAAA--- ------------------------------AA-----AEREPCGKLQPASRDA------- ------------------------------------------------------------ -PGPVSAKKGRAEEK--KAPRRLNGEGGS--------G-G-------------------- -----------------------HG------------------------------R--QP P--------AAP----SPQG---------------------------------------- -----------------------------------------------------------C -GG--PAPWS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------LAALPAASAPAPARSGSAGAPALPPAPPPRLLLPAAA AAAAAARARPRRPKERRGASAGGTARASAAPPARRTARGRRRREVGRAPR---------- -----------GG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIR----EREKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEGQEAKGILSDNIKDYSGKNWD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLRRLDTLEFKQLIHIEHQPNGGASVIHAYSGELSHLSPVEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDPAQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSPGSTSSVLGPHADNVICAVS----------------------------- ------RTSLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYGLQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PLASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----SNMDGRNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEL KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------QFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQEGLCPGSLLSLV-- ----DAR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAR--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SEQERK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------VLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSSARP00000008982 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKQKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDNIKDYIGNTLD-NKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSDF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLKFKQLIHIEHQPNGGASVIHAYSNELSNLSPVEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQ----- -HGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLECRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------DEDTVQNT--------------------- -----TTH---------------------------------------------------- -----VT-GTLSDSTSSVLGPCIDNMASAVS----------------------------- ------KSSLDFVLSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------THELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PMSSVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV CISEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------Q---------- ----NNMDSKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF EMDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSHISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----N------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSEASP00005024112 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------EPCGKLQPASRDA------- ------------------------------------------------------------ -PGPVSAKKGRAEEK--KAPRRLNGEGGS--------G-G-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------HGFFFFAAP-----------------------------SPQSCG---- --------GPAPWSLFFFLAASAPAPARSGSASGAWGAGLGGSGVPPWGQEMELVVAVAA GAMVFFFSLRAVP----------------------------------------------- --------ARARALRGRPRGAGGSGLAAGDAQGSAG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------PRRY-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KI--------------K-DKIR----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEGQEAKGILSDNIKDYSGKNWD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLRRLDTLEFKQLIHIEHQPNGGASVIHAYSGELSHLSPVEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDPAQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSPGSTSSVLGPHADNVICAVS----------------------------- ------RTSLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYGLQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PLASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV YIPEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----SNMDGRNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEL KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------QFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQEGLCPGSLLSLV-- ----DAR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SAR--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SEQERK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------VLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSOCUP00000029591 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AYPMGSPGRCPGHSAPSPAGAS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TLLHTQPHQLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAASAANAKP----------------------RRPKEKREKE----R------------- -----------RR-H-----GLGGA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GREENGEVK-------PLPL------------------------------------ ------------------------------------------------PR------EKVK VKE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------KD----------------------KEK-E -KKKHK-V--MSEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILSDNIKDYIGKNLD-TKNY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPMEMERFAEEFVGLVFSEN-E NSSAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDTSQNT--------------------- -----ATH---------------------------------------------------- -----ET-GTSPDCSSSVPGPHPDSTRCAGS----------------------------- ------KTSVDSGFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQT KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------GNV NISEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------S---------- ----NNMDGKNVKGKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KE--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------SKEELCPGSLINLI-- ----DTR----------------------------------------------------- ----------------------------------QP----S------------------- ------------------------------------------------------------ ------------------------------------------SAH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDGK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPCAP00000012109 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVQGTAA--- ------------------------------NVAAAAVSEKEPFTKLQSPSGDP------- ------------------------------------------------------------ -PSSLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NG------------------------------RQLQP PPP---PPAAVP----LPQS---------------------------------------- -----------------------------------------------------------Y -GS--SASWSFA-------ALSAAPSPSSSSRSSFSFSTGSAA----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSAS---------------ASSSQSLPR------ -------KLLVPPTLLHAQPHHLLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAASSANAKP----------------------RRPKEK---------------------- --------------------------------WKKERRSTGLAG-----GGRXXXXXXXX XXXXXXXXXXXX------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------X------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--INEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----G-GKEKPKTSIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGILNDSLKDYMGKNLD-TKNC---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RIH NNLRRLDTLEFKQLIHIEHQPNGGASVIHAYSNELTHLSPVEMERFAEEFVGLVFSEN-E NSASYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQ----- -HGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEASPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EDDHSYST--------------------- -----ATH---------------------------------------------------- -----ET-STSSDATSSVLGPQADSVVCAGS----------------------------- ------KTSLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQRI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASIRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NISEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------S---------- ----NNMDSKNVKGKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVHFTEF KSDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQEESCAGSHINLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------STH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNPDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSODEP00000008311 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AA--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVRGAAA--- ------------------------------AAP--AVSEKEPFGKLQSSSRDP------- ------------------------------------------------------------ -PASLSAKKVRMEEK--KAPRRVNGDGG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------G------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------RQALAPPPLSGGGPAPWNKIKDKIKER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKSNVE-DLQSKKVKKKKKKKHKESEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDEAAKGVLSDNIKDY--------------------- ------------------------------------------------------------ ----------VAKS------------ADPRNS-----DCRI-------P----------- ------------------ENSDF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVE KTLRRLDTLEFKQLIHIEHQPNGGASVLHAYSSELSCLSPVEMERFAEEFVGLVFSEN-E NSAAFYVMGIVHGAAAYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSSFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLQLESRRDS DDGPIMWVRPGEQMIPVADVPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEIVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------KEDVTQST--------------------- -----AAH---------------------------------------------------- -----ET-AASLDSM--------------------------------------------- ------KTSFDSAFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELSQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PHASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNI NISEKTKA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDGKTIKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEM KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KE--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SVH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQETK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCLAP00000011578 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AA--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PVRG-AV--- ------------------------------AAP--AVSEKEPFGKLQSSSRDP------- ------------------------------------------------------------ -PASLSAKKVRMEEK--KAPRRVNGDGG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------GGRRRPLH----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KI--------------K-DKIK----DRD------------------------KER-E -KKKHK-V--MSEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNAE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDETAKGVLSDNIKDYTGKSLD-PKSY---------- ------------------------------------------------------------ -----SSKVS-------------------------------------------------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVALKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ KTLRRLDTLEFKQLIHIEHQPNGGAAVLHAYSSELSRLSPVEMERFAEEFVGLVFSEN-E NAAAFYVMGIVHGAAAYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLQLESRRDS DDGPIMWVRPGEQMIPVADVPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEIVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------KEDVTQST--------------------- -----AAH---------------------------------------------------- -----ER-GASPDSMSVVLGPHTDN----------------------------------- ------KTSLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KCELPQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PHASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNI NIPEKMRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NSMDGKNITAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEI KIDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KE--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------IKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SVH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDRK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCGRP00001003209 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AA--------------------------------------------- -----------------------------------------------PPG---------- --------------------------------------------------PAYR------ --------------------------------AVAAPAETEARGPLQPASRPPAAP---- -----------------------------------------------------------A MP----AKKVRTEEK--RAPRRVNGEGGS--------G-G-------------------- -----------------------NG------------------------------R--QP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------F -GG--PAAWSFA-------AVPAASSA--------------AC----------------- ----PAA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------APASPRSRFSF---------------------------------------- --------------------------PASPATSSAPA----------------------- ---SASSSPPPAA--------------------PSP------------------------ ------------------------------------------------------------ --------------------------------------------LLAQPQREPLPPA--- ----AAAAKP----------------------RRPKERRERE----K------------- -----------RR-HS---LGLG------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RHENGEAKPPPPLPLPP-------------------------------------- ------------------------------------------------SR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----EKDKE----------------------KER-E -KKKHK-V--MSEIKKENGDVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DAEDQEAKGILNDNIKDHIGKSLD-AKNC---------- ------------------------------------------------------------ -------------------------------------GSKV-------P----------- ------------------DNRDF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ SNLKRLDTLEFKRLIHAEHQPNGGASVVHAYSDELSCLSPVEMQRFAEEFVGLVFSEN-E SSAAYYVMGIVHGAATYLPDFLDYFSYNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQVSLVGAVDEEVGDFFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GHRPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHA-------------------EEDTCHST--------------------- -----VSH---------------------------------------------------- -----EA-CISSGPTSSVLGPHTDNRVCAVNL---------------------------- ------QTSSDSVFSDRLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQV KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HPASIRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VKV NIPEKTRT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNTEGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFSDF QINM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLTNIV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SIH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKN---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------NLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCGRP00000012888 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KI--------------K-DKIK----EKDKE----------------------KER-E -KKKHK-V--MSEIKKENGDVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DAEDQEAKGILNDNIKDHIGKSLD-AKNC---------- ------------------------------------------------------------ -------------------------------------GSKV-------P----------- ------------------DNRDF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ SNLKRLDTLEFKRLIHAEHQPNGGASVVHAYSDELSCLSPVEMQRFAEEFVGLVFSEN-E SSAAYYVMGIVHGAATYLPDFLDYFSYNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQVSLVGAVDEEVGDFFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GHRPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHA-------------------EEDTCHST--------------------- -----VSH---------------------------------------------------- -----EA-CISSGPTSSVLGPHTDN----------------------------------- ------QTSSDSVFSDRLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQV KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HPASIRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VKV NIPEKTRT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNTEGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFSDF QINM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLTNIV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SIH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKN---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------NLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCGRP00015012852 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AA--------------------------------------------- -----------------------------------------------PPG---------- --------------------------------------------------PAYR------ --------------------------------AVAAPAETEARGPLQPASRPPAAP---- -----------------------------------------------------------A MP----AKKVRTEEK--RAPRRVNGEGGS--------G-G-------------------- -----------------------NG------------------------------R--QP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------F -GG--PAAWSFA-------AVPAASSA--------------AC----------------- ----PAA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------APASPRSRFSF---------------------------------------- --------------------------PASPATSSAPA----------------------- ---SASSSPPPAA--------------------PSP------------------------ ------------------------------------------------------------ --------------------------------------------LLAQPQREPLPPA--- ----AAAAKP----------------------RRPKERRERE----K------------- -----------RR-HS---LGLG------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RHENGEAKPPPPLPLPP-------------------------------------- ------------------------------------------------SRG--------- --------------------GFK------------------------------------- ---------KNFFP---------------------------------------------- ------------------------------------------------------------ ---------------------TG------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DAEDQEAKGILNDNIKDHIGKSLD-AKNC---------- ------------------------------------------------------------ -------------------------------------GSKV-------P----------- ------------------DNRDF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ SNLKRLDTLEFKRLIHAEHQPNGGASVVHAYSDELSCLSPVEMQRFAEEFVGLVFSEN-E SSAAYYVMGIVHGAATYLPDFLDYFSYNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQVSLVGAVDEEVGDFFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GHRPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHA-------------------EEDTCHST--------------------- -----VSH---------------------------------------------------- -----EA-CISSGPTSSVLGPHTDNRVCAVNL---------------------------- ------QTSSDSVFSDRLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQV KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HPASIRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VKV NIPEKTRT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNTEGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFSDF QINM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLTNIV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SIH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKN---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------NLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMAUP00000018335 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPG---------- --------------------------------------------------PAYC------ --------------------------------AVAVLAGKEACGKLQPASRQPVTP---- ------------------------------------------------------------ MP----AKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------HARLPFGLLASWLSCFSLPSSISHGPVSLLCWLYVSRYFSRRLGLSL FSTVSLLHHAPWMYQSFSWRKKILTVLNFFV----------------------------- --------------------FSD------------------------------------- --KI--------------K-DKIK----EKDKE----------------------KER-E -KKKHK-V--MSEIKKENGDVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKANIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTVCSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DAEDQEAKGILNDNIKDRIGKPLD-GKNC---------- ------------------------------------------------------------ -------------------------------------GSKI-------P----------- ------------------DNGDF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVE SNLKRLDTLEFKRLIHAEHQPNGGASVIHAYSDELACLSPVEMQRFAEEFLGIVFSEN-E SAAAFYVMGIVHGAATYLPDFLDYFSYNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQVSLVGAVDEEVGDFFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GHRPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLCDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHA-------------------EEDTCRST--------------------- -----VSH---------------------------------------------------- -----ET-CTSSGPTSSALGSHTDNRV--------------------------------- -------SSSDSVCSDKLPS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KHESQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HIASVRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VKV NLPEKTRT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNTEGKNIKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFSDF QIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFKNSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLTNIV-- ----DTR----------------------------------------------------- ----------------------------------QH----G------------------- ------------------------------------------------------------ ------------------------------------------SIH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKN---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------SLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPEMP00000002663 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPN---------- --------------------------------------------------PAYG------ --------------------------------AAAVLSEKEAFGKLQPAAREP------- ------------------------------------------------------------ -PGSGSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NG------------------------------RQLQP P--------AAP----PPQSTAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KI--------------K-DKIK----EKDKE----------------------KEK-E -KKKYK-V--MSEIKKENGDVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTSVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DAEDREARGILNDNIKDYIGKHLD-SKNR---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------DDSEL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ KNLKRLDTLEFKQLLHIEHQPNGGASVIHAYSDELSCLSPVEMQRFAEEFVGLVFSEN-E SSAAFYVMGIVHGAATYLPDFLDYFSYNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDFFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GQRPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHA-------------------EEDTCHSA--------------------- -----VTH---------------------------------------------------- -----ET-CVSSASTSSVLGPHTEN----------------------------------- ------QTSSDSVFSDKLHP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQT KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASTRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VKV NIPEKTRP---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NNTEGKNVKTKL---------E---------------------------------- ------------------------------------------------------------ -----------------------------------------------------RVQFSDF QIIM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------FKEELCPGSLINIA-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SVH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKN---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------NLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMUGP00000013099 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPN---------- --------------------------------------------------PARG------ --------------------------------PVAVLSEKEAFGKLQPSSREP------- ------------------------------------------------------------ -PGPVSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NG------------------------------R--QQ P----------------PQG---------------------------------------- -----------------------------------------------------------Y -GS--PAAWSFA-------ALAAASAA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------APPRSCFSF---------------------------------------- --------------------------PASPAASSAPACPA--------QAPPRKPLVAPS LLHA-------------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------QPPRVPLPP---- -----AAAKP----------------------RRPKEKRDKE----K------------- -----------RR-H-----GLGGA-----A----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ARDENGEAKPPP----PP-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----EKEKE----------------------KER-E -KKKHK-V--MSEIKKENGDVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNLE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGFL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DAEDQETKGILSDNIKDYIGKNLD-TKNC---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------NNSDF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKRLDALEFKQLIHVEQQPNGGASVIHAYSSELSCLSPVEMQRFAEEFVGLVFSEN-E SSAAFYVMGIVHGAATYLPDFLDYFSYNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GQWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHE-------------------EEDTCHST--------------------- -----VTH---------------------------------------------------- -----EKDIISSGPMSSVFGAHTEN----------------------------------- ------QTSSDSVFPDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KNELPQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASIRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VKV NISEKTRT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNTEGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFSDF QIDT-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENTN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------IKEEVCPGSVTNIV-- ----DTS----------------------------------------------------- ----------------------------------QR----S------------------- ------------------------------------------------------------ ------------------------------------------SVY--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------D------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------NLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSNGAP00000015004 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPN---------- --------------------------------------------------PAHN------ --------------------------------AVALLAEKEAFGKLQSSSREP------- ------------------------------------------------------------ -PGSMSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NG------------------------------RQLQP P------------------S---------------------------------------- -----------------------------------------------------------Y -GG--PTAWSFA-------ALPAASSP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------SPSRSCFSFA-GPAVSSAS---------------SSASQPVPH------ -------KLLVAPSLLHAQPHSVLLPPAAPS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AAAKP----------------------RRPKEKREKE----K------------- -----------KR-H-----GLGG------A----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SRDENGEAK-------PQ-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----EKDKE----------------------KER-E -RKKHK-V--MSEIKKENGDVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------GVEDQEAKGILNDNIKDYCGKNLD-TKNC---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLKKLDTLEFKQLIHIEHQPNGGASVIHVYSNELSCLSPVEMERFAEEFVGLVFSEN-E GSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLNMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHV-------------------KEDTSHST--------------------- -----VAH---------------------------------------------------- -----ET-GRSPDPTSSVLGPHTDNKTCAVN----------------------------- ------KTSLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KHELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIACIRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VKV NITEKTRA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NSLDGKNAKAKV---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------RVQFTDL KIGM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KE--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLINIV-- ----DTR----------------------------------------------------- ----------------------------------QC----S------------------- ------------------------------------------------------------ ------------------------------------------SVH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKN---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSOARP00000019426 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PAPRP GAEESAP----------------------------------------------------- ----------------------------------AAVSEKESFGKVQAPSRDP------- ------------------------------------------------------------ -PGPLSAKKIRTEEK--KAPRRLNGEGAS--------S-G-------------------- -----------------------NS------------------------------RQLQS P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PGSWSFA-------ALSAAPSP-SSARSNFSFSAGTAV----------------- ----P------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSVS---------------ASHSQQVPR------ -------KL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------RVSSTRHSLQTGLHGLLL KCRAIAYVIKPEYPLEKMGQSRLSFPLG--------------GWRQYGSVILPLPALYLF CLL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTSAE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEARGILNDNIKDYSGKSLD-TKSY---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NNLRRLDTLQFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVDLVFSEN-E NSAAFYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEDSPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------EEDTAENT--------------------- -----VTH---------------------------------------------------- -----ET-GTSPDSTSSVLGPHTDSTICAVS----------------------------- ------KTSLDSIFSDKVHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYELQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------RA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNMDGKNVKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KVEV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELCPGSLISLV-- ----DTR----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------STH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQERK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMOCP00000010607 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AA--------------------------------------------- -----------------------------------------------PPN---------- --------------------------------------------------PAPG------ --------------------------------AAAALSDREAFGKLQPASREP------- ------------------------------------------------------------ -PGAASAKKVRTEER--KAPRRVNGDGG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GSGG---------RQPGRRGEERSLEIGPVAGFVLATQPPTPENPVKKKNE KKKRRKKREKE------------------------------------------------- ------------------------------------------------------------ ----------------------N------------------------------------- --KI--------------K-DKIK----ENDKE----------------------KER-E -KKKHK-V--MSEIKKENGDVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICAGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------EAEDQEAKGVLNDHIKDYIGKHLN-AKNC---------- ------------------------------------------------------------ -------------------------------------DSKV-------S----------- ------------------GNSES------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ HNLKRLDTLEFKRLVHIEHQPNGGASVVHAYSNELSCLSPVEMQRFAEEFVGLVFSEN-E SSAAFYVMGIVHGAATYLPDFLDYFSYNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDFFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GQRPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHA-------------------EEDTCHSA--------------------- -----VTH---------------------------------------------------- -----ET-YMSSGPKSSVLEPHT------------------------------------- ----------DSVFSDKLPS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYESQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIAPARTK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------ED----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------LRV TVAEKTRT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NSTEGKTVKTKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFSGF QMDV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFEDSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------FREELCPGSLTDIV-- ----DTR----------------------------------------------------- ----------------------------------QQ----S------------------- ------------------------------------------------------------ ------------------------------------------SVH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKK---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DD------------------------------- ---G-------------------------------------------------------- --------------------------------------------------------NLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMUSP00000039482 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPN---------- --------------------------------------------------PARG------ --------------------------------AVALLSEKEASGKVQPSSREP------- ------------------------------------------------------------ -PGSMSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NG------------------------------GQLQ- -----------------PQS---------------------------------------- -----------------------------------------------------------F -GS--PAAWSFA-------ARPAASSS--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------STSRSCYSFSASPSVSSAS---------------ASSSQPLPR------ -------KLLVTPSLLHAQPHRVLLPPVAPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AAAKP----------------------RRPKEKREKE----K------------- -----------RRQH-----GLG------AA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ARDENGEAK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----EKD------------------------KER-E -KKKHK-V--MSEIKKENGDVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ----------------------AEDQEAKSILSDNVKDCIGKNLD-TKNC---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------DNSDF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RDK NNLRRLDTLAFRQLIHIEHQPNGGAAVIHAYSNELSCLSPMEMQRFAEEFVGLVFSEN-E SSAAFYVMGIVHGAATYLPDFLDYFSYNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEASPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GQRPD-QPRVTKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKFYHA-------------------EEDTCHSTSE------------------- -----STH---------------------------------------------------- -----EK-GIASGPTSSVLGAHTEN----------------------------------- ------QASSDSVLSDKLPS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYESQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PGAALRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------GMA PIPEKIRT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNTEGKNSKARL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------RAQFSDF HIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------AFENTN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEDSCPGSVSNTV-- ----DTQ----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SVR--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SSQDRS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------SLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >MGP_SPRETEiJ_P0069388 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPN---------- --------------------------------------------------PARG------ --------------------------------AVALLSEKEASGKVQPSSREP------- ------------------------------------------------------------ -PGSMSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NG------------------------------GQLQ- -----------------PQS---------------------------------------- -----------------------------------------------------------F -GS--PAAWSFA-------ARPAASSS--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------STSRSCYSFSASPSVSSAS---------------ASSSQPLPR------ -------KLLVTPSLLHAQPHRVLLPPVAPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AAAKP----------------------RRPKEKREKE----K------------- -----------RRQH-----GLG------AA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ARDENGEAK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----EKD------------------------KER-E -KKKHK-V--MSEIKKENGDVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ----------------------AEDQEAKSILSDNVKDCIGKNLD-TKNC---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------DNSDF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RDK NNLRRLDTLAFRQLIHIEQQPNGGAAVIHAYSNELSCLSPMEMQRFAEEFVGLVFSEN-E SSAAFYVMGIVHGAATYLPDFLDYFSYNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEASPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GQRPD-QPRVTKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKFYHA-------------------EEDTCHST--------------------- -----VTH---------------------------------------------------- -----EK-GIASGPTSSVLGAHTEN----------------------------------- ------QASSDSVLSDRLPS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYESQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PGAALRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------GTA PIPEKIRT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNTEGKNSKARL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------RAQFSDF HIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------AFENTN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEDSCPGSVSNTV-- ----DTQ----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SVR--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SSQDRS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------SLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMSIP00000032129 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPN---------- --------------------------------------------------PARG------ --------------------------------AVALLSEKEASGKVQPSSREP------- ------------------------------------------------------------ -PGSMSAKKVRTEEK--KAPRRVNGEGAS--------G-G-------------------- -----------------------NG------------------------------GQLQ- -----------------PQS---------------------------------------- -----------------------------------------------------------F -GS--PAAWSFA-------ARPAASSS--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------STSRSCYSFSASPSVSSAS---------------ASSSQPLPR------ -------KLLVTPSLLHAQPHRVLLPPVAPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AAAKP----------------------RRPKEKREKE----K------------- -----------RRQH-----GLG------AA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ARDENGEAK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----EKD------------------------KER-E -KKKHK-V--MSEIKKENGDVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ----------------------AEDQEAKSILSDNVKDCIGKNLD-TKNC---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------DNSDF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RDK NNLRRLDTLAFRQLIHIEHQPNGGAAVIHAYSNELSCLSPMEMQRFAEEFVGLVFSEN-E SSAAFYVMGIVHGAATYLPDFLDYFSYNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEASPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GQRPD-QPRVTKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKFYHA-------------------EEDTCHST--------------------- -----VTH---------------------------------------------------- -----EK-GIASGPTSSVLEAHTEN----------------------------------- ------QASSDSVLSDRLPS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYESQQI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PGAALRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------GTA PIPEKIRT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNTEGKNSKARL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------RAQFSDF HTDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ASENTN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEDSCPGSVSNTV-- ----DTQ----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SVR--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SSQDRS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------SLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >MGP_CAROLIEiJ_P0066777 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPN---------- --------------------------------------------------PARG------ --------------------------------AVALLSEKEASGKVQPSSRES------- ------------------------------------------------------------ -PGSMSAKKVRTEEK--KAPRRVNGEGAS--------G-G-------------------- -----------------------NG------------------------------GQLQP P--------AAP----PPQS---------------------------------------- -----------------------------------------------------------Y -GS--PAAWSFA-------ARSAASSS--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------STSRSCYSFSASPSVSSAS---------------ASSSQPLPR------ -------KLLVTPSLLHAQPHRVLLPPVAAP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AAAKP----------------------RRPKEKREKE----K------------- -----------RRQH-----GLGA-----AA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ARDENGEAK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-EKIK----EKDKE----------------------KER-E -RKKHK-V--MSEIKKENGDVRILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ----------------------AEEQEAQSIISENGKDCIGKHLD-TKNC---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------DNSDF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SDK NNLRRLDTLAFRQLIHIEQQPNGGAAVIHAYSNELSCLSPMEMQRFAEEFVGLVFSEN-E SSAAFYVMGIVHGAATYLPDFLDYFSYNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEASPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GQRPD-QPRVTKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKFYHA-------------------EEDTCHST--------------------- -----VTH---------------------------------------------------- -----EK-GIASGPTSSVLGAHTEN----------------------------------- ------QASSDSVLSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYESQQI KQE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVAALRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VTV PIPEKIGT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNTEGKDSKARL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HAQFPDF HIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------TFESTN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEDSCPGSVSNTV-- ----DTQ----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SVR--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SSQDKS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------NLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >MGP_PahariEiJ_P0048216 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPN---------- --------------------------------------------------PARG------ --------------------------------AVAVLSEKEAFGKVQPASRDS------- ------------------------------------------------------------ -PGSMSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NG------------------------------GQLQP P--------VAP----TPQS---------------------------------------- -----------------------------------------------------------Y -GS--PAAWSFA-------ARSAASSS--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------ATSRSCYSLSASPSVASAS---------------ASSSQPLPR------ -------KLLVTPSLLHAQPHRVLLPPVAPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -AAAAAAAKP----------------------RRPKEKREKE----K------------- -----------RR-H-----GLG------AA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ARDENGEAKP------PP-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KV--------------K-DKIK----DKD------------------------KER-E -RKKHK-V--MSEIKKENGDVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ----------------------AEDQDAKGILNANVKDCIGKNLD-TKNC---------- ------------------------------------------------------------ -------------------------------------DSKI-------P----------- ------------------DNSDF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RDK NNLRRLDTLEFRQLIHIEHQPNGGASVIHAYSNDLSCLSPMEMQRFAEEFVGLVFSEN-E SSAAFYVMGIVHGAATYLPDFLDYFSYNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEASPFLKCTLPWGTLSSLKLECRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GQRPD-QPRVTKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKFYHT-------------------EEDTCHST--------------------- -----VTH---------------------------------------------------- -----EK-GIASGPMSSVLGAHTEK----------------------------------- ------QASSDSVLSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYESQQI KQE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVAALRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VTV TIPEKIRT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NNTEGKNSKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFSDL QIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KYENTS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEDSCPGSVSNTV-- ----DTQ----------------------------------------------------- ----------------------------------QH----S------------------- ------------------------------------------------------------ ------------------------------------------SIH--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SNQDKS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------NLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSRNOP00000051335 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPN---------- --------------------------------------------------PARG------ --------------------------------PVAVLSEKEAFGKLQPSSRES------- ------------------------------------------------------------ -PGSMSAKKVRTEEK--KGPRRVNGEGDS--------G-G-------------------- -----------------------NG------------------------------GQLQP P--------AAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--PAAWSFA-------ARPAASSQ--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------ATPRGCYAFSASPSVSSAS---------------ASSSQPVPR------ -------KLLVASSLLHAQPHRVLLPPVTPP----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AAAKP----------------------RRPKEKREKE----K------------- -----------RR-H-----GLG------GA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----DRDENGEAK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----EKDKE----------------------KER-E -RKKHK-V--MSEIKKENGDVKIFLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNIE-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ----------------------AEDQEAKGILNDNVKDCIGKHLD-TKNC---------- ------------------------------------------------------------ -------------------------------------DSKV-------P----------- ------------------DNSDF------------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KGKLDRVEFTEFKFGGDSKFETGNKDLQEKL G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KNTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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----------ALPALAAGGD-GGG------------------------------------ --------A--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AREENGDVK----------------------------------------LLL---- ------------------------------------------------QR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------A------------------------------------- --QI--------------K-DKIK----ERDK-----------------------KQK-E -KKKHK-I--MNEIKKENGEVKLLQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----G-GKEKPKTNAE-ELQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DIEDQEAKGIIDDHLKDFNGKNMDPKKDY---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWYV-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEELSQNT--------------------- -----NTV---------------------------------------------------- -----EA-GTSADPKSSVIGLQTDNRICTTS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KNTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------TKFSDTLQTKYLQQELTS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHQ--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASHRVK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------S---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DLAGKTVA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NDTEGQNVQTRL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVELTPF KFEV-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFEPGN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------IKDKICPG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SHIHPDDTRQHSSSY- ----------------------------------P--NLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCPGP00000003319 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PLRGAV---- ------------------------------------------------------SPEPEP F--GARPAPDAKVS-------------------------RGSQPAAKKMKAADERSLKGA --------------------KRVNGEGGG--------G-GGNG----------------- -----------------GSGKQAL------------------------------------ PLPAVLPS---------------------------------------------------- -----------------------------------------------------------Y -GS--PAAWGFP-------AL--------------------------------------- --------------------------------PSGPSGGAGGFAFPSQLPRKLLSPAVLL PSSASPSSSSYQQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HQHRHHRHRLALAVEAGGCGSGAAAVG--------------- ------SAKP----------------------KRPKEKRDKE----R------------- -----------RK-H-----G--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------ALPVVAAVGD-GGGGL---------------------------------- ------SAA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GREENGEVK----------------------------------------LLL---- ------------------------------------------------PK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------A------------------------------------- --QI--------------K-EKIK----EREK-----------------------KQK-E -KKKHK-I--MNEIKKENGEIKLLQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----A-GKEKPKTNAE-ELQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DIEDQEAKGIIDDHLKDFNGKNMDPKKDC---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWSE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEELSQNT--------------------- -----STV---------------------------------------------------- -----EA-GTSADSKSSVIGLQTDSRICTIS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KNTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------TKFSDALQTKYLQQEFMP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASHRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DLAEKTVA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------S---------- ----NDVGAQNVQARL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVELAAF KLEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KLEPGS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQGKLCPG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GHIHPDDTRQHSSSY- ----------------------------------P--KLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCPUP00000020581 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PLRGAV---- ------------------------------------------------------SPEPEP F--GARPAPDAKVS-------------------------RGSQPAAKKMKAADERSLKGA --------------------KRVNGEGGG--------G-GGNG----------------- -----------------GGG---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QQVWPLRGSGGLRFPLTTAPEAAVPRCFA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------AVHQHRHHRHRLALAVEAGGCGSGGAAGG--------------- ------SAKP----------------------KRPKEKRDKE----R------------- -----------RK-H-----G--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------ALPVVAAVGD-GGGAL---------------------------------- ------SAA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GREENGEVK----------------------------------------LLL---- ------------------------------------------------SK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------A------------------------------------- --QI--------------K-DKIK----EREK-----------------------KQK-E -KKKHK-I--MNEIKKENGEIKLLQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----A-GKEKPKTNAE-ELQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DIEDQEAKGIIDDHLKDFNGKNMDPKKDC---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWSE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEELSQNT--------------------- -----STV---------------------------------------------------- -----EA-GTSADSKSSVIGLQTDSRICTIS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KNTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------TKFSDALQTKYLQQEFMP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASHRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DLAEKTVA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------S---------- ----NDVGAQNVQSRL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVELAAF KLEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KLEPGT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQGKLCPG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GHIHPDDTRQHSSSY- ----------------------------------P--KLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSABRP00000001756 ------------------------------------------MI---------------- ---------------------------------------------STTRPQGSVVTLTRQ LPHLLLAIHSSTHLLPSTRRKTLEKKGGCLSWESLEHKIFFFLS---------------- ------------------------------------------------------------ ------------TA---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------GKEKPKTNAE-ELQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGIIDDHLKDFNGKNMDPKKDC---------- ------------------------------------------------------------ -------------------------------------ESMI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWSE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEELSQNS--------------------- -----STL---------------------------------------------------- -----EA-GTSADPKSSVIGLQTDSRICMIS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KNTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------TKLSDALQTKCLQQEFMP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PVASHRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------S---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DLAEKTVA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------L---------- ----NDTRGQAVQTGL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------RTELATF KFEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFEPAN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQGKLCPG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SHIHPDDTRQHSSSY- ----------------------------------P--KLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSAPLP00000012032 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGIIDDHLKDFNGKNMDPKKDC---------- ------------------------------------------------------------ -------------------------------------ESMI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWSE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEELSQNS--------------------- -----STL---------------------------------------------------- -----EA-GTSADPKSSVIGLQTDSRICMIS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KNTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------TKLSDALQTKCLQQEFMP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASHRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------S---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DLAEKTVA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NDIRGQAVQTGL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------RIELATF KFEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFEPAN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQGKLCPG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SHIHPDDTRQHSSSY- ----------------------------------P--KLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMUNP00000021159 ------------------------------------------I----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------EQACVPGVVAEVSGKLDSTHLWPSALQFAELYHISTFE---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----G-GKEKPKTNAE-ELQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DIEDQEAKGIIDDHLKDFNGKNMDPKKDC---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWSE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEELSQNT--------------------- -----STV---------------------------------------------------- -----EA-GTSADPKSSVIGLQTDSRICTMS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KNTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------AKFSAALQTKYLQQEFMP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASHRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------MDV DLPEKTVA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NDAGGQTVQTRL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVELTAF KLEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFEPGS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQGKLCSG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GHVHPDDTRQHSSSY- ----------------------------------P--KLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSSCAP00000010525 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------FYSSFTEKYYLLLEISFSLC- ----------------------VCIPQENCLDTKIVEHKYFKIGRMQVSKVEKIIIFFFF KLSTG-GKEKPKTNAE-ELQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DIEDQEAKGIIDDHLKDFNGKNMDPKKDY---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWSE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEELSQNT--------------------- -----NTV---------------------------------------------------- -----EA-GTSADPESSVVGLQTD-RVCTVS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KDTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------TKFPDALQTKYLQQEFVP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PLASLRVK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DVAEKTVT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NDVGGQSVQARL---------G---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HAELASL KLEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFETGN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQGKLCSG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GHVHPDDTRQPSSSY- ----------------------------------P--KLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSJHYP00000012526 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DIEDQEAKGIIDDHLKDFNGKNMDPKKDC---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWCE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEELSQNT--------------------- -----NPV---------------------------------------------------- -----EA-GASADPKSSVVGLQTD-RACTVS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KNTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------TRFPDALQTKYLQQEFVP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PLASLRVK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DVAEKTVT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NDVGGQNVQARL---------G---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HAELTSL KLEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFETGN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQGKLCSG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GHVHPDDTRQPSSSY- ----------------------------------P--KLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSZALP00000015701 ------------------------------------------H----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------KRQETQTHVSQLLVLLSSICIFHV QPLNHQQE---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------FVIPCTNNL-------------------- ----------------------------------------------------------FF KLSTG-GKEKPKANAE-ELQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DIEDQEAKGIIDDHLKDFNGKNMDPKKDC---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWCE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEELSQNT--------------------- -----NPV---------------------------------------------------- -----EA-GTSADPKSSVVGLQTD-RVCTVS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KDTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------TKFPDALQTKYLQQEFVP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PLASLRVK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DVAEKTVM---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NDVGGQNVQPRL---------G---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HAELTSL KLEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFETGN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQGKLCSG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GHVHPDDTRQPSSSY- ----------------------------------P--KLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCCEP00000011209 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------KLIVKTSLRDLS----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------F KLSTG-GKEKPKTNAE-ELQIKKVKKKKKKKHKENEKKK--------------------- -------------R----PKMYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DFEDQEAKGILDDHLKDFSGKSMDPKKDC---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWSE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEELSQNT--------------------- -----STV---------------------------------------------------- -----EA-GTSADPKSSVVGLQTD-RICTMS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KDTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------TKFPDALQTKYLQQEFLP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PLASLRVK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DIAEKTVT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NDVRGQNVQARL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HAELTSL KLEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFEPGN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQGKLCSG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GHVHPDDTRQPSSSY- ----------------------------------P--KLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSPMJP00000004085 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------LPS---------- --------------------------------------------------PGRGAA---- ------------------------------------------------------PPEQEV L--GARTAPDAKGS-------------------------RGSQPAAKKVKGAEERSLKGA --------------------KRVNGEGGG--------G----G----------------- -----------------GSAKQ-------------------------------------- PLPAVVPS---------------------------------------------------- -----------------------------------------------------------Y -SS--PGPWGFA-------TL--------------------------------------- --------------------------------PSGPSAGTGGFAFPSPLSRKLLPPAVLL PPSASPSSS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------HPQHQHRHHRHRLALAAEAGG-------GG--------------- ------SAKP----------------------KRPKEKRDKE----R------------- -----------RK-H-----G--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------VLPVVASAGD-GGGAL---------------------------------- ------S----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----REENGEVK----------------------------------------LLF---- ------------------------------------------------PK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------G------------------------------------- --QI--------------K-EKVK----EREK-----------------------KQK-E -KKKHK-I--MNEIKKENGEIKLLQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----G-GKEKPKTNAE-ELQIKKVKKKKKKKHKENEKKK--------------------- -------------R----PKMYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DFEDQEAKGIIDDHLKDFSGKSMDPKKDC---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWSE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEELSQNT--------------------- -----STV---------------------------------------------------- -----EA-GTSADPKSSVVGLQTD-RICTMS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KDTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------TKFPDALQTKYLQQEFLP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PLASLRVK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DIAEKTVT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NDVRGQNVQARL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HTELTSL KLEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFEPGN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQGKLCSG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GHVHPDDTRQPSSSY- ----------------------------------P--KLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSFALP00000010898 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --QI--------------K-DKVK----EREK-----------------------KQK-E -KKKHK-I--MNEIKKENGEIKLLQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----G-GKEKPKTNAE-ELQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DIEDQEAKGIIDDHLKDFNGKNMDPKKDC---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWSE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEELSQNT--------------------- -----STV---------------------------------------------------- -----EA-GTSADPESSVVGLQTD-RICTMS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KDTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------TKFPDALQTKYLQQEFLP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PLASLRVK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DLAEKMVT---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NDLGGQNVQARL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVELTSL KLEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFEPGN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKGKLCSG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GHVHPDDTRQPSLSY- ----------------------------------P--KLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSLCOP00000012629 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------STTRFLGSVVPEVFLAPTSITCKKTPKALEGKHFKTKD----------- --------------------------ILRDFF---------------------------- ------------------------------------------------------------ -LSTG-GKEKPKTNAE-ELQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DIEDQETKGIIDDHLKDFSGKNMDPKKDC---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWSE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEELSQNM--------------------- -----STV---------------------------------------------------- -----EA-ETSADPKSSVAGLQTDKRVCTMG----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KDTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------TKLSDALQTKYLQQEFMP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PLASHQIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DLAEKTVA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NDVGGQNVQSRL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVELTSL KLEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFEPGN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQGKLCSG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GHVHPDDTRQHSSSY- ----------------------------------P--KLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMVIP00005010407 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------TPKALEGKHFKTKESIYLGNHLNVL SLSECFLPLGHYTLFSVQFVYYVNLKVLRDFF---------------------------- ------------------------------------------------------------ -LSTG-GKEKPKTNAE-ELQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DIEDQETKGIIDDHLKDFSGKNMDPKKDC---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWSE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEELSQNM--------------------- -----STV---------------------------------------------------- -----EA-ETSADPKSSVAGLQSDKRVCTMG----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KDTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------TKLSDALQTKYLQQEFIP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PLASHQIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DLAEKTVA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NDVGGQNVQSRL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVELTSL KLEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFEPGN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQGKLCSG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GHVHPDDTRQHSSSY- ----------------------------------P--KLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCJPP00005005535 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------SGRGAA---- ------------------------------------------------------SPEREL FCASARPGPDTKVS-------------------------RGSQPASKKLKGADERGLKGA --------------------KRVNGE-GG--------G-GG------------------- -----------------------SS------------------------------KQQQQ PLPAAVPG---------------------------------------------------- -----------------------------------------------------------Y -GN--PAAWGFA-------AL--------------------------------------- --------------------------------PPGPSVSAAGFAFPSPLPRKLLPPALLL PPAASPSPSC-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------P------------------------ ------------------------------------------------------------ -------------------QHRHHRHR------------PAPAGE--------------- ------AAKP----------------------KRPKEKRDKE----R------------- -----------RK-H-----G--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------ALPAL---GDGGGGAL---------------------------------- ------SAA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GREENGDVK----------------------------------------LLL---- ------------------------------------------------QK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------A------------------------------------- --QI--------------K-EKMK----EREK-----------------------KQK-E -KKKHK-I--MNEIKKENGEIKLLQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----A-GKEKPKTNAE-ELQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGIIDDHLKDFSGKNMDPKKDC---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWSE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEEPSPNA--------------------- -----STL---------------------------------------------------- -----EA-GTSADPKSSVMGLQTDSRICTIS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KNTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------AKLSDA-----LQQEFAL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASHRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ 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----HDSRGQNVQTRL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------QVELTAF KLEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFEPGN---------------------------------------- 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---D-------------------------------------------------------- --------------------------------------------------------FLR- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSMGAP00000019365 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --QI--------------K-EKMK----EREK-----------------------KQK-E -KKKHK-I--MNEIKKENGEIKLLQK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----A-GKEKPKMNAE-ELQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGIIDDHLKDFNGKNMDPKKDC---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWSE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEEASQNA--------------------- -----GTL---------------------------------------------------- -----EA-GTSADPKSSVMGLQTDSRICTIS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KNTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------AKLSDV-----LQQEFMP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASHRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DLAEKTVA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----HDSRGQNVQTRL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------QVELTAF KLEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFEPGS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQGKLCPG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SHVHPDDTRQH-SSY- ----------------------------------P--KLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSGALP00000060938 KEPGPIHSASSLSMSISSDEITPGLLLSGLNSPGSLSLSSHRT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DERGLKGA --------------------KRVNGEGGG--------G-GG------------------- -----------------------SS------------------------------KQQQQ PLPAAVPS---------------------------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----A-GKEKPKTNAE-ELQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTICSGLV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DVEDQEAKGIIDDHLKDFNGKNMDPKKDC---------- ------------------------------------------------------------ -------------------------------------ESKI-------P----------- ------------------ENSEF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVQ NKLKRLDTLEFKQLIHIEHQPNGGASVIHAYSNELSHLSPVEMERFAEEFVGLVFSEN-E NCAAYYVMGIVHGAATYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWSE-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLFDNDIYFIPRNVVHQFKTVSAVCS LAWHIRLKLYHS-------------------EEEPSQNA--------------------- -----STL---------------------------------------------------- -----EA-GSSADPKSSVIGLQTDSRICTIS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KNTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------AKLSDV-----LQQEFMP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASHRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DLAEKTVA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----HDGRGQNVQTRL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------QVELTAF KLEM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KSEPGN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQGKLCLG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SHVHPDDTRQH-SSY- ----------------------------------P--KLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCPRP00005021138 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------RNTS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ED-------------------------------------------------------- -------------------------------------TKFSDALQTKYIQQEFTQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LVSSHRIK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------S---------------- ------------------------------------------------------------ ---------------------------------------------------------MNV DLPEKTVA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NDMERQNVKTKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVELTEF KFEA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFQSGN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KD--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LQDKLCPG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SHLSLDDTRQHGSTY- ----------------------------------P--NLHGQ------------------ ------------------------------------------------------------ --------------------------RED------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------FLC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCCNP00000004609 ------------------------------------------M----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AE--------------------------------------------- -----------------------------------------------PPS---------- --------------------------------------------------PMHGSAAAVA AVSEK-------------------EPLGRQQ---------------QPSSRDA------- ------------------------------------------------------------ -SGPLSAKKVRTEEK--KAPRRVNGEGGS--------G-G-------------------- -----------------------NSS-----------------------------RQLQP A------AAAAP----SPQS---------------------------------------- -----------------------------------------------------------Y -GS--SASWSFA-------ALSAVPSA-SSSRSCFSFSAG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------PAVSSAS---------------ASSSPPVPR------ -------KLLVPPTLLHAPLPRVLLP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAAAPTAAKP----------------------RRPKEKREKE----R------------- -----------RR-H-----GLG------GA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AREENGEAK-------PL-------------------------------------- ------------------------------------------------PR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- --KI--------------K-DKIK----ERDKE------------------------K-E -KKKHK-V--MSEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKTNVE-DLQIKKVKKKKKKKHKENEKRK--------------------- 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SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLKLESRKDS DDGPIMWVRPGEQMIPVADMPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GQWPD-QPRITKDVICFHAEDFLEVVQRM QLDLHEPPLSQCVQWVDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------DEDTSQNI--------------------- -----ATH---------------------------------------------------- -----EI-GTSPDPTSSVLGPHTDNMISAVS----------------------------- ------KTPLDSVFSDKLHS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------KYDLQRI KHE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIASVRVK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------EE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ---------------------------------------------------------VNV NIPEKTAA---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------P---------- ----NIMDVKNIKAKL---------D---------------------------------- ------------------------------------------------------------ -----------------------------------------------------HVQFTEF KIDM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ES-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------KFENSN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -KE--------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------LKEELC---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------NIVLY-------------- ------------------------------------------------------------ -TQIKI-------------------EKDD------------------------------- ---D-------------------------------------------------------- --------------------------------------------------------ILC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ >ENSCAPP00000014293 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------IK----ERDKE----------------------KER-E -KKKHK-V--MNEIKKENGEVKILLK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----S-GKEKPKANVD-DLQIKKVKKKKKKKHKENEKRK--------------------- -------------R----PKMYSKSIQTVCSGLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------S--------------- ---------------------DAEEEAAEGVL---------------------------- ------------------------------------------------------------ -------------GGRDRTGRAADPRA---------------------P----------- ------------------ESSAL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------PFVSLKEP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RVG ETLRRLDALEFKQLIHVEQQPNGGAAVLHAYGGELARLAPPEMERFAEEFVGLAFSEN-E SAAALYVMGIVHGAAAYLPDFLDYFSFNFPNSPVKMEILGKKDIETTTMSNFHAQVKRTY SHGTYRAGPMRQISLVGAVDEEVGDYFPEFLDMLEESPFLKCTLPWGTLSSLQLESRRDS DDGPIMWVRPGEQMIPVADVPKSPFKRK-------RTTNEIKN-LQYLPRTSEPREMLFE DRTRAHADHIGQGFERQTTAAVGVLKAVHC-GEWPD-QPRITKDVICFHAEDFLEIVQRM QLDLHEPPLSQCVQWIDDAKLNQLRREGIRYARIQLYDNDIYFIPRNVVHQFKTVSAVCS LAWHVRLKLYHS-------------------QDDVTQST--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------AAQEAGASPPSDSRMCAARKTSSESG FSDKLHLKYELAVKEE---------------------PMSVNPPVKA------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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