>ENSECRP00000023184 M----------------------------------------------------ME----- ---------------G-MGKESPLSCRRPFLWLN-H-----------TEN-----NAHPC FWKFSD---------CFSSY---------------DQ---PIP-FSKKT----------- ------------------T-DYMENRKPVLELKDVP--PP-PH----HAAS--------N PF-PALPI----PG---SA---------------------------SCFQSA-------- ----------------------QQE---SPRKLHP----------QPD------------ ------------------GPQV--SVCA-HCE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GSRQVQHGGSSAGLFNNIG-GGSSSTGGGGGTGCGVSLHI NKPLDTLNSSTTGTITCQVGSTI----------------------------------NPP LHSLRDP----------------------------------------------------- -----------------------------Y------------------------------ ------------------------------------------------------------ PRIHGA--------G--------------------------------CE----------- ------------------------------------------------------------ ------------------------------------------------------------ -MPHH------------------------------------------------------- -------TGASSQSLGTQQHLPCCAGLL-------------SQLH--------------- ---PF---------------SSKSSSFGPSSLHLPLSSGVLPSHSGHVAHTGCYSCEREF VPGARLEPLYS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --THDDLPTTTLL----------------------------------------------- --------------------------------------CA--------------N-PLHM NAEH-TLFLKGTHYCRDCLRK--------------------------------------- ---PARPQ-VSD----SVKVWPNIPPPSAQSA----PIPMCNGCGVPGTAADGVLLL--G SSLGKETQKYG------SPDLSAQENLPPIGVFWDIENCSVPSGRSAMAVVQRIRERFFK GHREAEFICVCDISKENKEVIQELNNSQVTVAHINATAKNAADDKLRQSLRRFADTHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-KNQASDALLQHANTHVTFEDFVSDLPPR VLVK-------VQPCNTLLYIYNLPANRD------------GKSVSNRLRRLSDNCGGKV LS--ISSGIAILRFSSRDAAERAFKRMENEDVFGNKISVSF------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------IPPAKVGPEVEPGNGPASSSCSSSSQAAEK---PRSPKRVGRT---- -TR------LCQNNGDPT----------DEQSYSPRKGANSGNGSAGKNIRVKSLQELCT LESKQKLNKELDRKTRNETP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SPQ--------------TDLEPTSGVSVGSKCAAG----------- -------------------------------------------------IGEQSFRA-K- ---------------------------RRD------------------------------ --------------------------CSTPRSITDSPVERTDKTSIGSIG---------- -----------------------------------------------------------F HISTPSAFSKLTLQRTTSPLV------LSQGSW-SS--RSGSPSLSNRSSPAVPTL---- N-SAC----------------PD-PFSSGMDIHVTNLDYRMSRKELHQVLHDAFSKYGQV VSLELSPHTDYQLRASVQMGTLQEAISAVSGLHRYKMGSRRIQVSLVTGT-NKSLSLLSS ETVSILQDAPACCLPLFKFTEIYEKKFGRKLAISDLYKLTDVMAVRDQGNTRLICLLPSS QARQSPLGSS--LSHDG-SSANCSPVVFEELEYHEPICKQHSTMQSFSESDFDPDSYKIP FVVLSLKSFAAQVHSLLQSHEGTLPLLSFPDCYASEFSSLNLVEEGE---GVSLEHLITC IPGINIVTAQNGIKVVKWIHNKPPPPN-SD------AWIHRCKSPIGNPQLIQFSREVID MMKNQPSCVIPISKFIPLYHYHFAKQCRVSDYGYSKLLELLEAVPHVLQILGMGSKLMLT LTHRAQVKRFTQDLLKLLKSQASKHVVIRDFVQAYHWCFSKDWNVISYGVCELMDLLTEI PDTTVCVSQQDGDVVISIPKK-ER-TQEELERTKHFAKEVVDLLRHQPHFRMSFSKFIPS YHHHFGRQCKLTYYGFNKLLELFEAIPDVLQVLECGEEKILALTEVEKVKALAAQLVKLL RSQKDNSLPVTDLITEYCKTFGYGLRLQDFDVSSVSALLQKL-CHVVKVVDTLVGREVQL INRKSLRSLTTQLLVLLMSHTSPSSSL--------------------------------- --------------SLNQLIAQYEFTYGSPLNPCEYGFVSLGELLKSLPNLVE------- ---VFVNEEE-----------------------------------G-CPP--EECVRLTR LYEFARSARALLHTYHYQQIFLSEFPSAFCKYTGKALHARTYGYTTMEELLCAIPQVVWI KGHGHKKIVVLKNDMK----------------ARTSPLCLPAEKTTIIVNSRGQKSSDVD GLAQPSTPSSGSGQTDP------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ELMCLSGSSPVDLLCGPVPSCLPSPQL HPDPVVLE-HIDLIRFEEQ----------------------------------------- ----------------------------------P------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SQ-------------------------------- ------------------------ITGMLVLTDDEKILGVAATTIGSDA----------- --------------------------------------------------------P--- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PLD------------------------- ------------------------------------------------------------ --------TVFTGSISDPRVSLPPNHESTETL---------------------------- ----KTV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------VTESPAKRSSRSKVK LAANFSFTPV-----------------------------------------TRL >ENSLOCP00000008831 T----------------------------------------------------ME----- ---------------A-MVKESSLCGPTAFQWLG-H-----------TDD-----EAASR IWKLSD---------CFSAFDADKKKDLFPVWPFQED----------------------- ---------------------FMENRKPALELKDVP--PP-PQ----CAGS--------K PF-PSAPL----PR---AP---------------------------PCFQ---------- ----------------------------------P----------LPQEPVLQKQQQQQQ T----------------GSPKV--SVCT-HCE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------AGT--------------- PV----R----------------------------------------------------- ---YGAEGARLGRRLGCGLVGD-------------------------GGGGGGGGVSFHV PKPPEAPN----GTITCQVG--------------------------------------PA ---LRPP----------------------------------------------------- -----------------------------L------------------------------ ------------------------------------------------------------ P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------HQHLPCCAGLL-------------GQLHSLPAASTSFSRARLL PAGP-------------------------------------------------------- ------------------------------------------------------------ -------------------------------------SAPVHQDCLATAGYY-PCGVDFS PGG-R-----------------------------------------GD------------ ----------------------------------------------------------QR FGPRAHLSSAAHL----------------------------------------------- --------------------------------------CT--------------N-HLHL NVDR-TVCLKGTHYCRECLRK--------------------------------------- ---PSRAL-AVE----AGKAWPNIPPPPAQSAPV--PIPVCNGCGVPGATADGLLLL--G ASLGASSQKYG------SPESGGQENLPPIGVFWDIENCSVPSGRSAMAVVQRIRHRFFQ GHREAEFMCVCDISKENKEVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFADTHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-KNQASEALLQHAHRHVAFEEFVSDLPPR MPVK-------TQPSFTLLYVRNLPTNRD------------GKSVSNRLRRLSDNCGGKV LS--ISAGSAVLRFGSRDAAERARKRMENEDVFGNRIAVSFSSSWAKEGAAGEAEKLPPP SLPSGSPLAP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------EK---PRSPKRTGRT---- -VR------LCQSGRDPA----------PEQTCSPRKGVSAAGSSAAKSAQVKSLQELCK METKPKMNYQLEKKSRNDTP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SPQ--------------SN---------------GE---------- ------------------------------------VTYHSSTACKSVSMGESSYRS-R- ---------------------------RKD------------------------------ --------------------------SLTPRSVSDSPVEKAER----GVG---------- ----------------------------------------------------------EF QVSTPSAFSKLNLQRTLSPLV------LSQGSW-SS--RSGSPSLSNRSSPLAATL---- NHSPC-PDVPQ-----------D-PFSNGVDIQVANVDYRMSRKELQQILRNTFSKHGRV KSVELSPHTDYQLRATVQMSTLQEAISAVSGLHRYKIGGKRIHVSLVTGTNNKSLAVLSS EIISILQDAPACCLPLFKFTEIYEKKFGHKLAVCDLYKLTDVVAVRDQGSGRLVCLLPSS QARQSPLGSS--QSHDG-SS-SGSPVVFEELEYHEPICRRHYTDPGFSEADFDPDTYKIP FVVLSIKAFAAQVHSLLQTHEGTVPLLSFPECYASEFSPLELSEEGEAEGCVPLEHLITC IPGINIVTSQNGIKVIKWIHNKPPPPN-AD------PWVQRCKSPVGNPQLIQFSREVID LMKSQPCCLMPVSKFIPSYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQV---------- --RRAFFKRFTQDLLRLLKFQVSKQVVIQDFMQAYHWCFSRDWNVTEYGACELMDLLAEI PDTTISVTQQDSDLVISIPKR-ER-TPEEIERTKQFAKEVVDLLRHQPRCRMPFNKFIPS YHHHFGRQCKLTYYGFTKLMELFEAIPDVLVVLECGEEKILTLTEVERLKALAAQFVKLL RSQKDNSLPVSDLLTEYSKTFGYGLKLQDFDVGSVLTLLQKL-CHVVKVVDTPSGREVQL INRKSLRSLTTQLLVLLMSLPDGQDSL--------------------------------- --------------WTEELSQQYEAAHGVALNPCEYGFVSLGELLKSLPYLVE------- ---LFESEE----------------------------------------G--EERVRLTR LYQFGRSVRALLHTYHYQQIFLTEFPSAFSKYTGKGLQPRSYGYSTVEELLGAIPQVVWI KGHGHKKIIVLKNDMK----------------VRTSPV---------------------- ----------------PL-----P------------------------------------ ------------VESSQPDSEEQPQCHSR------RDST--------------------- -------------------------------HSGPVS------P---------------- --------------------------------------------------------G--- ---TVSTEA------------------------ELLCLSSGSPVDLLCGPVPSCLPSPQL HPDPVPLG-HTDLIQFEEQ----------------------------------------- ----------------------------------P------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PQ-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----HTVSLHLLGIQERRTDKNVKTAPDTATHEPSDPVVLCSFS---------------- ------------------------------------------------------------ ------------------------------------------------------------ PPPPP------------------------------------------------------- ---------------------------------AGVAQPSCHKAPLTDSPGRRASRNKVK LAANFSFSPV-----------------------------------------TRL >ENSPKIP00000030566 T----------------------------------------------------ME----- ---------------S-LGKESSFCSSRPFKWL--N-----------SEN-----EAPSR LWNLSN---------CFSSF---------------EQ---TNP-LKDKQ----------- ------------------K-VYMENRKPVLELKDVP--PP-PH----HNSS--------K AF-HAASL----PP---PR---------------------------PCLP---------- ----------------------------------P-----------------QESLQQQP T----------------GGPKV--STCS-HCDS------------------------GLR LGSDIRHSGGALGCVGV-------GGGGGVGG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PSHL---------------------------------- ----------------------------------IAKAEDAGAG---------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------MSCPVG--------------------------------------PP ---LRHP----------------------------------------------------- -----------------------------Y------------------------------ ------------------------------------------------------------ PSVAEAYTQAHPPEG--------------------------------CE----------- ------------------------------------------------------------ ------------------------------------------------------------ -LPLP------------------------------------------------------- -------LVATSQPLASHQHLPCCTGLL-------------QPLH--------------- ---P-------------------------------------------------------- ---------YSTFPLGCGQ--PKLLP---------P------------------------ ---------------------------------APAVSAPLHGSCVASSGYYVECGL--- -GT-R-----------------------------------------GD------------ ----------------------------------------------------------QH FPTHGDVSTSTHL----------------------------------------------- --------------------------------------CT--------------N-PLHL NVEH-TICLKGAHYCSECLSK--------------------------------------- ---SAMSV-AKD----TKKTWPHVPPPPAKSAPI--PVPMCNGCGVTGTSADSFLLV--G TSLGKS----G------SPESGLQENLPPVGVFWDIENCSVPSGRSAVAVVQRIRNCFFL GHREAEFICVCDISKESKEVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFADTHTAP ATVVLVSSDVNFGSELSDLRHRHGFRVILVH-KNQASEALLQHAHQHVAFEDLVADLPSR VPLK-------PQPCFTLLYVSNLPTNRD------------GKSLANRLRRLSDNCGGKV LS--ISAGCAVLRFGSREAAERASKRMENEDVFGSRISVS-------------------- -------LCPRAEEASGP------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LPAV---------------------------- ------------FVP-------------------------VEK---PRSPRRLGRI---- -AR------LCQ------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------GPPELSGASRK VGGAPGGPVGRSLQDLCRTEPKPKVFQLEKKIRGDSVSPLNNDIPIQLSSKSDSVGEREF QVSTPSAFSKLSLQKTFSPLI------LSQGSW-SS--RSASPCLSSRSSPLT------- --------VPSCSPHPDA--SPE-PFSDGVDILVANMDYRMSRKELQQTLHSTFSKYGRV RSVELSPHTDYQLRATVQMRSLQQAVTAVSNLHRHKIGTKRVHVSLLTGTSSRSLAPLSS EIISILHDSPACCLPLFKLTEIYEKKFSRKLAVSDLYKLNEVLAVRDQGGSRLVCLLPSG QARQSPLGSS--QSHDG-SSASGSPVVFEELEYHEPVCRQHHSQRVFSESDFDPDSYKIP LVMLPLKPFAAQVHSLLQTHEGTVPLLSFPECYAAEFCPIALG-EGELEGGIPLEHLITC IPGVNIVTAQNGFKVVKWIHNKPPPPN-AD------PWVQRCKSPVGNPQLIQFSREVVD LIKNQPHCIMPVSKFIPSYHHHFGKQCRVSDYGYSKLLELLEAVPHVLQILGMGSKRLLT LTHRAQVKRFTQDLLKLLKFQVSKQVVIRDFMQAYHWCFSRDWSVVEYGMCDLMDLLSEI PDTTITITLQDTDTIISIPKR-ER-TPEEVERTKQFAKEVVDLLRHQPHCRMPFSKFIPS YHHHFGRQCKLSYYGFTKLIELFEAIPDVLLVLECGGEKILSLTEMEKLKALAAQFVKLL RSQKDSRLPLTELLTEYSKTFGYGLKLQDFDVSSVPGLLQKL-CHVVKVVDGVRGREVQL ISRKSLRSLTTQLLSLLMSLPAEQDSL--------------------------------- --------------AVEELSRQYEATHGTPLNPCEYGFISLGELLKSLPYLVE------- ---LFEGED----------------------------------------GASKEWVGLTP LYQFARSVRALLHTYHYNQIFLTEFLGAFGKFTGKGLLPDSYGYSTVDELLGAIPQVVWI KGHGHKKIIVLKNDMK----------------VRSSP----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ITTESSQKEGGGSARNPESQSSASNTVEKELLCLSLGSPVDLLCGPVPSCLPSPQL HPDPVLLQ-QTDLIRFEEQ----------------------------------------- ----------------------------------PSLNLVNVEKPDLN------------ ------------------------P----------------------------------- ----------------------------------------------------AAPHVCES PTVVQEDQPPKPGAASPGSKPRGPK----------------------------------P CMSE-------------------------------------------------------- -------------------------SP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------KRASRNKVK LAANFSVTPV-----------------------------------------TRL >ENSCGOP00000027825 M----------------------------------------------------ME----- ---------------G-PGKERSICSSRPFPWLG-H-----------PKT-----EASTL LWKLKD---------CFPTK---------------ET---TSASPTDRE----------- ------------------N-NFMDSRKAVLELKDVP--PP-PL----HHTS---SSQSSQ PF-SLVPL----PM---PP---------------------------SCLP---------- ------------PPHLTQDSL-QQK---------P--------------------QQQQE G----------------ASPKV--SIYT-TCDYCSTD----------------------- -------------------GYGLLGGGSAVG------------------SSSSIAGVVSL YMAPDSLGASSS------ISRS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G PL---------------------------------------------------------- ------------------------------------------------------------ ----------------------------------CSLASSVHQYKHHTSCG--GEVLDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LPTLGFKPQLSS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPVSSHPYLSCCSGLLQNYPAV-------------------------- ------------------------------------------------------------ -------------PLPCSQ--PSLFPSSALL----------------------------- ----------VSSLP-----------------------APLHASCLASSGYY-TCGVDCC PSA-R-RPQRS-TLGDHPTTTTITTTTTTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMHL NVER-TVCVTGAHYCQECLFK--------------------------------------- ---PMNGL-VSE----SDTVWPNVPIP--QTTPI--PIPICNGCGS---SSDSMMLMP-T GSLGKTGQKYG------SPENGGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRGRFFQ GHREAEFICVCDISKENKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILIH-GNHASSALLQHAHRHVAFQEITADLPPR MLVK-------AQPSFNLLYVHNLPVNCDKSLRNAVKL---------RLRRLSDNCGGKV LG--MSQGTAVLRFGSNEAAARARKRMENEDVFGHQISLSFS------------------ ---------PRPRDDASPEPELQSRPHHLPQPMTLPQTYQSQDS---------------- -----------MF----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GPP----------------- -----------------------------PSI---------------------------- --------SSFSFLP-------------------------LEK---PRSPRRPRRA---- -TR------PCHAPG-PE----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELGSLEGKPRI GSHHLEKG-RAASSSPH--------------SN---------------GETGSLEQLPKP GLAGESIYRR-------------------------------------------------- ---------------------------RRE------------------------------ --------------------------GSYSRSVTESPVE-GDR----SSG---------- ----------------------------------------------------------DF QISTPSAFSTLNLHRSFSPLI------LSQGSW-SS--RSASPCLSSRSSPLLAAP---- -RSPC-PE---------G--LPE-PFSDGAELQVANLDYRMSRKDLQQTLHDTFSRYGRV KAVELSPHTDYQLKATIQMCSLQQAISAVSGLHRYKIGGKRIQVSLITGGCNKSLAMLST EIINILQDAPANCLPLFKFTEIYEKKYSRKLLVGDLYRLPEVVAVREQGGSRLVCLLSSS QIRQSPLGSC--QSQEASSSASGSPVVFEELEYHEPVCREHYTQRDFSEADFDPDSYKIP FVVMNLRTLASEVHSLLQSHDGTLPLLSFPDCYAAKFSPLQLGNE-TLEGGVPLEHLITC VPSITIVTAQNGFKVIKWIHNKPPAQN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPFCIMPMSKFIPSYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRDWRVIDYGICDLMDLLTEI PDTTITVVNQDTDTVISVPKR-ER-TVDEMERTKQFGKEVVDLLRHQPHCRMAFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPSILMVLECGEEKVLTLTEVERIKALAAQLVKLL RAQKNSSLPVSQLLTEYSKTFGYGLRLQDYDASSLPALLTKL-CHVVKVVDGSGCREVQL INRKSLRSLTSQLLSLLMS------------------------------------QEEEQ VTRGL---------RVEEVSLHYLTVHGAPLTPCEYGFLSLSELLKSLPYLVE------- ---LYIDESD-DN---------TACNAA------SG------------CG--EEWVRLTR LYQFARNVRSLLHTYHYNQIFLTEFQGVYNKFTGCSLEPRFYGYTSTDELLSAIPQVVWI KGHGHKRIIVLKNDMK----------------ARASP----------------------- -----SVPCS------PQ-----P-GENTESP---------------------------- -----------------------------------RESP-------------------MS YTTSGTQS-----------------------------------P---GC----------- ------------------------------------------------------------ ---DGAAES------------------------ELLGL--TSPVDLLCGPVPSCLPSPQL YPDPVLLQ-ETDLIHFEE------------------------------------------ --------------------------------KAP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------TVSDDPDAAAVADGTDDSAVTK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----PDM-------------------KLPLSV---------------------------- -----------------------------------------------DSPSRRATRSRIK LAANFSFTTG-------------------------------------------L >ENSSPAP00000022466 M----------------------------------------------------ME----- ---------------E-LGKERSICSSRPFPWLS-H-----------PKT-----EASTL LWKLKD---------CFSTN---------------ET---TAPHQTDKE----------- ------------------N-NYMDNRKPVLELKDVP--PP-PP----HHTS---SSQLTQ PF-SLAPL----PL---PP---------------------------PCLPPHQLT----- QDSHHHHQQQQQPPP----------------------------------------QQQQE G----------------ASPKV--SICT-RCDYCSTD----------------------- -------------------GYGLLRG------------------------SSRVAGVVSL YMAPGSLGA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PI---------------------------------------------------------- ------------------------------------------------------------ ------------------------SSSSTSRSGPCSVASSVHQYKH--SCGNRGEVFDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LLNFSCKPQLPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPLSSHPYLPCCSGLLHTYPAV-------------------------- ------------------------------------------------------------ -------------SLPCSQ--PSLFPSSAPPASSLP------------------------ ---------SVSSLS-----------------------APLHGSCLTSSGFY-TCGVDCS PSA-R-RSQRS-ILGDHPTTTTI--TTTTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMHL NVER-TVCVKGAHYCQECLLK--------------------------------------- ---PVNGL-TSE----LDKVWPNVPAP--QSAPI--PIPVCNGCGT---SSDGMVLMS-S TSLGKTGHKYG------SPETSGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GNHTSSALLQHAHRHVAFQEITADLPPR MLVK-------AQPSFNLLYVHNLPVICDKSLRNAVKL---------RLRRLSDNCGGKV LG--MSQGTAVLRFGSPEAAARARKRMENEDVFGRRISLSFS------------------ ---------PRPRDDASPEPELQSQPHHLPQPQPLPQTYHTQDS---------------- -----------MF----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GPP----------------- -----------------------------PYI---------------------------- --------SSFSFLP-------------------------LEK---PRSPRRPRRA---- -TR------PCYTPG-PV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELGSLEVKPRM GFHHLEKG-RPASSSPH--------------SN---------------GETGTLEQLSKP GLTGESMYRR-------------------------------------------------- ---------------------------RRE------------------------------ --------------------------GSNPRSVTESSVEQEDR----SSG---------- ----------------------------------------------------------EF QISTPSAFSQLNLHRSFSPLV------LSQGSW-SS--RSASPCLSSRSSPLLATP---- -RSPC-PE---------G--TPE-PFSEGAEVQVANLDYRMSRKDLQQTLYDTFSRYGRV KSVELSPHTDYQLKATIQMLSLQQAIGAVSGLHRYKIGGKRIQVSLITGSSSKTLAFLST EIICILQDAPANCLPLFKFTEIYEKKYSRKLAVGDLYKLPEVVAVREQGGSRLVCLLPNS QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYAQQDFSEADFDPDSYKIP FVVMSLSTLASEVHSLLQSHDGTLPLLSFPDCYAAKFSPLHLGNE-TLEGGVPLEHLITC VPSITIVTAQNGFKVIKWVHNKPPAPN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCIMPISKFIPLYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRNWRVIDYGICDLMDLLAEI PDTTITITHQATDTVISVPKR-ER-TVEEMERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDILMVLECGEEKVLTLTEVERIKALAAQLVKLL RAQKNSSLPVSQLLTEYSKTFGYGLRLQDYDASSLLALLTKL-CHVVKVVDGSEGREVQL INRKSLRSLTSQLLALLMS------------------------------------QEEDQ VIRGL---------KVEELSQHYLTVHGTLLNPCEYGFLSLSELLKSLPYLVE------- ---LYHEESD-ESCEAGITATSH--------------------------G--EEWVRLTR LYQFARNVRALLHTYHYNQIFLTEFQGVYNKFTGCSLEPRSYGYTSTDELLSAIPQVVWI KGHGHKKIIVLKNDMK----------------AKPSC----------------------- -----SVPNS------PQ-----P-GENMESP---------------------------- -----------------------------------RDSP-------------------TS TATSGAQS-----------------------------------P---GG----------- ------------------------------------------------------------ ---DVATDS------------------------ELLCL--TAPVDLLCGPVPSCLPSPQL HPDPVGLQ-QTDLIHFEE------------------------------------------ --------------------------------KTQ------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------T------------ASD------- ESEVA---------------------------------AADSTSDAPEQPGSTEGSAITK PPPPPET-------------------KTALSM---------------------------- -----------------------------------------------DSPSRRSTRSRIR LAANFSFTAG-------------------------------------------L >ENSAOCP00000001729 M----------------------------------------------------ME----- ---------------G-LGKERSICSSRPFPCLS-H-----------PKT-----EASTL LWKLKD---------CFSTN---------------ET---TSPHRTDKE----------- ------------------N-NYMDNRKPVLELKDVP--PP-PP----HHTS---SSQLSQ PL-SLAPL----PL--PPP---------------------------PCLLL--------- ------------PPQLTQDSHQQQQ---------P-----------PH------QQQQQE G----------------ARPKV--SICT-RCDHCSTD----------------------- -------------------GYGLLDG------------------------RSSVAGVVSL YMAPGSLGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PI---------------------------------------------------------- ------------------------------------------------------------ ------------------------SSRSTSRSTLCSVASSVHQYKH--SCGSQGEVFDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LLNFSCKPQLPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPLSSHLYLPCCSGLLHTYPTV-------------------------- ------------------------------------------------------------ -------------PLPCSQ--PSLFPSSAPPASSLP------------------------ ---------SLSSLP-----------------------APLHGSCLASSGFY-TCGVDCS PSV-R-RSQRS-ILGDHPATTTI--TTTTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMHL NVER-TVCVKGAHYCQECLLK--------------------------------------- ---PVNGL-TSE----SDRVWPNIPVP--QTAPI--PI--CNGCGT---SSDGMVLMP-S TTLGKTGYKYG------SPESSGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GNHTSSALLQHAHRHVAFQEITADLPPR MLVK-------AQPSFNLLYVHNLPVICDKSLRNAVKL---------RLRRLSDNCGGKV LG--MSQGAAVLRFGSPEAAARARKRMENEDVFGRRISLSFS------------------ ---------PRPKDNASSEPELQAQPHHL--PQPMPQTYHTQDS---------------- -----------EF----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------APP----------------- -----------------------------PHI---------------------------- --------SSFSFLP-------------------------LEK---PRSPRRPRRA---- -TR------PCYTPG-PV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELSSLEVNPKM GFHHLEKG-RPASSSPQ--------------SN---------------GETGALEQQSKP GLTGESMYRR-------------------------------------------------- ---------------------------RRE------------------------------ --------------------------GSNPRSVTESPVEQGDG----SSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLI------SSQGSW-SS--RSASPCLSSRSSPLLATP---- -RSPC-RE---------G--TPE-PFSEGPEVQVANLDYRMSRKDLQQTLYDTFSRYGRV KSVELSPHTDYQLKATVQMLSLQQAISAVSGLHRYKIGGKRIQVSLITGGNSKTLALLST EIICILQDAPANCLPLFKFTEIYEKKYSRKLVVGDLYKLPEVVAVREQGGSRLVCLLSNT QIRQSPLGSS--QSQECSSSASGSPVVFEELEYHEPICRQHYAQHDFSEADFDPDSYKIP FVVKSLSTLASEVHSLLQSHDGTLPLLSFPDCYAAKFSPLQLGNE-TMEGGVPLEHLITC VPSITVVTAQNGFKVIKWVHNKPPAPN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCVMPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRNWRVIDYGICDLMDLLIEI PDTTITITHQATDTVISVPKR-ER-TVEEIERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDILMVLECGEEKVLILTEVERIKALAAQLVKLL RTQKNSSLPVNQLLTEYSKTFGYGLRLQDYDASSLPALLTKL-CHVVKVVDGSEGREVQL INRKSLRSLTSQLLAVLMS------------------------------------QEEEQ VIRGL---------KVDELSQHYLTVHGALLNPCEYGFLSLSELLKSLPYLVE------- ---LYYEEND-ENSEAG-----N--------------------------G--EEWVRLTR LYQFARNVRALLHTYHYNQIFLTEFQGAYNKFTVCSLEPRSYGYTSTDELLSAIPQVVWI KGHGHKKIIVLKNDMK----------------AKPSC----------------------- -----SVPNS------PQ-----P-GENMESP---------------------------- -----------------------------------RDSP-------------------IS TATSGAQS-----------------------------------P---AG----------- ------------------------------------------------------------ ---DVAIDS------------------------ELLCL--TAPVDLLCGPVPSCLPSPQL HPDPVGLQ-QTDLIHFDE------------------------------------------ --------------------------------RTQ------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PR-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ESDEPEVA---VP----------------------- ----------------------------------------DSTSDRPEQPGSTEDSAVTK PPPPPET-------------------KTILSM---------------------------- -----------------------------------------------DSPSRRATRSRIR LAANFSFTAG-------------------------------------------L >ENSAPEP00000025918 M----------------------------------------------------ME----- ---------------G-LGKERSICRSRPFPCLS-H-----------PKT-----EASTL LWKLKD---------CFSTN---------------ET---TSPHRTDKE----------- ------------------N-NYMDNRKPVLELKDVP--PP-PP----HHTS---SSQLSQ PL-SLAPL----PL--PPP---------------------------PCLPL--------- ------------PPQLTQDSHQQQQ---------P-----------PH------QQQQQE G----------------ARPKV--SICT-RCDHCSTD----------------------- -------------------GYGLLDG------------------------RSSVAGVVSL YMAPGSLGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PI---------------------------------------------------------- ------------------------------------------------------------ ------------------------SSHSTSRSTLCSVASSVHQYKH--SCGSQGEVFDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LLNFSCKPQLPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPLSSHLYLPCCSGLFHTYPTV-------------------------- ------------------------------------------------------------ -------------PLPCSQ--PSLFPSSAPPASSLP------------------------ ---------SLSSLP-----------------------APLHGSCLASSGFY-TCGVDCS PSV-R-RSQRS-ILGDHPATTTI--TTTTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMHL NVER-TVCVKGAHYCQECLLK--------------------------------------- ---PLNGL-TSE----SDRVWPNIPVP--QTAPI--PI--CNGCGT---SSDGMVLMP-S TTLGKTGYKYG------SPESSGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GNHTSSALLQHAHRHVAFQEITADLPPR MLVK-------AQPSFNLLYVHNLPVICDKSLRNAVKL---------RLRRLSDNCGGKV LG--MSQGAAVLRFGSPEAAARARKRMENEDVFGRRISLSFS------------------ ---------PRPKDNASSEPELQAQPHHL--PQPMPQTYHTQDS---------------- -----------EF----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------APP----------------- -----------------------------PHI---------------------------- --------SSFSFLP-------------------------LEK---PRSPRRPRRA---- -TR------PCYTPG-PV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELSSLEVNLKM GFHHLEKG-RPASSSPQ--------------SN---------------GETGALEQQSKP GLTGESMYRR-------------------------------------------------- ---------------------------RRE------------------------------ --------------------------GSNPRSVTESPVEQGDG----SSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLI------SSQGSW-SS--RSASPCLSSRSSPLLATP---- -RSPC-RE---------G--TPE-PFSEGPEVQVANLDYRMSRKDLQQTLYDTFSRYGQV KSVELSPHTDYQLKATVQMLSLQQAISAVSGLHRYKIGGKRIQVSLITGGNSKTLALLST EIICILQDAPANCLPLFKFTEIYEKKYSRKLVVGDLYKLPEVVAVREQGGSRLVCLLSNT QIRQSPLGSS--QSQECSSSASGSPVVFEELEYHEPICRQHYAQHDFSEADFDPDSYKIP FVVKSLSTLASEVHSLLQSHDGTLPLLSFPDCYAAKFSPLQLGNE-TMEGGVPLEHLITC VPSITVVTAQNGFKVIKWVHNKPPAPN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCVMPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRNWRVIDYGICDLMDLLIEI PDTTITITHQATDTVISVPKR-ER-TVEEIERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDILMVLECGEEKVLILTEVERIKALAAQLVKLL RAQKNSSLPVNQLLTEYSKTFGYGLRLQDYDASSLPALLIKL-CHVVKVVDGSEGREVQL INRKSLRSLTSQLLAVLMS------------------------------------QEEEQ VIRGL---------KVDELSQHYLTVHGALLNPCEYGFLSLSELLKSLPYLVE------- ---LYYEEND-ENSEAG-----N--------------------------G--EEWVRLTR LYQFARNVRALLHTYHYNQIFLTEFQGAYNKFTVCSLEPRSYGYTSTDELLSAIPQVVWI KGHGHKKIIVLKNDMK----------------AKPSC----------------------- -----SVPNS------PQ-----P-GENMESP---------------------------- -----------------------------------RDSP-------------------IS TATSGAQS-----------------------------------P---AG----------- ------------------------------------------------------------ ---DVAIDS------------------------ELLCL--TAPVDLLCGPVPSCLPSPQL HPDPVGLQ-QTDLIHFDE------------------------------------------ --------------------------------RTQ------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PR-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ESDEPEVA---VP----------------------- ----------------------------------------DSMSDRPEQPGSTEDSAVTK PPPPPET-------------------KTILSM---------------------------- -----------------------------------------------DSPSRRATRSRIR LAANFSFTAG-------------------------------------------L >ENSAPOP00000014334 M----------------------------------------------------ME----- ---------------G-LGKERSICSSRPFPCLS-H-----------PKT-----EASTL LWKLKD---------CFSAN---------------ET---TSPHQTDKE----------- ------------------T-NYMDNRKPVLELKDVP--PP-PP----HHTS---SSQLSQ SF-SLAPL----PLP-PPP---------------------------PCLPP--------- ------------PPPLTQDSHEQQQ---------P-----------P-------QQQQQE G----------------ARPKV--SICT-RCNYGSTD----------------------- -------------------GYGLLGG------------------------HSSVAGVVSL YMAPGALGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PI---------------------------------------------------------- ------------------------------------------------------------ ------------------------SSSSTSRSALCSVASSVHQYKH--SCGSRGEVFDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LLNFSCKPQQPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPLSSHPYLPCCSGLLHAYPTV-------------------------- ------------------------------------------------------------ -------------PLPCSQ--PSLFPSSAPPASSLP------------------------ ---------SISSLP-----------------------APLHGSCLASSGFY-TCGVDCS PSA-R-RSQRS-ILGDHPATTTI--TTTTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMHL NVER-TVCVKGAHYCQECLLK--------------------------------------- ---PVNGL-TSE----SDRVWPNIPVP--QTAPV--PI--CNGCGT---SSDGMMLMP-S TSLGKTGYKYG------SPESSGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GNHTSSALLQHAHRHVAFQEITADLPPR MLVK-------AQPSFNLLYVHNLPVICDKSLRNAVKL---------RLRRLSDNCGGKV LG--MSQGAAVLRFGSPEAAARARKRMENEDVFGHRISLSFS------------------ ---------PRPRDNASPEPELQAQPHHL--PQPLPQTYHTQDS---------------- -----------VS----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------APP----------------- -----------------------------PHI---------------------------- --------SSFSFLP-------------------------LEK---PRSPRRPRRA---- -TR------PCYTPG-PV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELSSLEVKLRM GFHQLEKG-RPASSSPQ--------------SN---------------GETGALEQLSKP GLTGESMYRR-------------------------------------------------- ---------------------------RRE------------------------------ --------------------------GSNPRSVTESPVEQGDG----SSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLV------SSQGSW-SS--RSASPCLSSRSSPLLATP---- -RSPC-PE---------G--TPE-PFSEGPEVQVANLDYRMSRKDLQQTLYDTFSRYGRV KSVELSPHTDYQLKATVQMLSLQQAISAVSGLHRYKIGGKRIQVSLITGGSNKTLSLLST EIICILQDAPANCLPLFKFTEIYEKKYSRKLVVGDLYKLPEVVAVREQGGSRLVCLLSNS HIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPICRQHYAQRDFSEADFDPDSYKIP FVVMSLSTLASEVHSLLQSHDGTLPLLSFPDCYAAKFSPLQLGNE-NMEGGVPLEHLITC VPSITIVTAQNGFKVIKWVHNKPPAPN-TE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCVMPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRNWRVIDYGICDLMDLLTEI PDTTITITHQATDTVISVPKR-ER-TVEEMERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDILMVLECGEEKVLTLTEVERIKALAAQLVKLL RTQKNSSLPVNQLLTEYSKTFGYGLRLQDYDASSLPTLLTKL-CHVVKVVDGLEGREVQL INRKSLRSLTSQLLALLMS------------------------------------QEKEQ VTRGL---------KVDELSQHYLTVHGALLNPCEYGFLSLSELLKSLPYLVE------- ---LYYEEND-ENGEAG-----N--------------------------G--EEWVRLTR LYQFARNVRALLHTYHYNQIFLTEFQGAYNKFTGCSLEPRSYGYTSTDELLSAIPQVVWI KGHGHKKIIVLKNDMK----------------TKPSC----------------------- -----SVPNS------PQ-----P-GENMESL---------------------------- -----------------------------------RDSP-------------------IS TATSGAQS-----------------------------------P---AG----------- ------------------------------------------------------------ ---DVATDS------------------------ELLCL--TAPVDLLCGPVPSCLPSPQL HPDPVGLQ-QTDLIHFED------------------------------------------ --------------------------------RTQ------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PR-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ESDEPEVA---VP----------------------- ----------------------------------------DGTSDRPEQPGSTKDSAVTK PPPPSET-------------------KTTLSM---------------------------- -----------------------------------------------DSPSRRATRSRIK LAANFSFTAG-------------------------------------------L >ENSSDUP00000028493 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------FF--------- ---------------IFQK-NYMESRKPVLELKDVPPPPP-PP---PHHTS---SSQPSQ PF-SLAPL----PL---PH---------------------------PR------------ -------------------SH-QQQ---------P-----------P--------HQQLE G----------------ATPKV--SICT-HCDYCSTD----------------------- -------------------GYGLLGGGGVVG------------------SSSSIAGVVSL YIAPGSVGA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PI---------------------------------------------------------- ------------------------------------------------------------ ------------------------SNSGISRSGPCSVTSSVHQYKNNLT----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------A-------------------------- ------------------------------------------------------------ -------------PLPCSQ--PSFFPSSAPLASSLP------------------------ ---------SVSTLP-----------------------VSLHGSCLASSGYY-TCGVDCS PSA-R-RSQRS-TLGDHPTSTTI--TTTTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMHL NVER-TVCVKGAHYCQECFLK--------------------------------------- ---------VGR----SDKIWPNVPAP--QTAPI--PIPICNGCGT---SSDSMMLMP-S TSLGKIGQKYG------SPENSGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GNHTSSALLQHAHRHVAFQEITADLPPR MLVK-------AQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------VGL---------------KNASLRL----- -------IRPNQGA-------NMGVYGSNPRSLTESPVEQGDR----SSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLV------LSQGSW-SS------------------------ --SPC-PE---------G--PPE-PFSEGTEVQVGNLDYRMSRKDLQQTLQDTFSRYGRV KAVELSPHTDYQLKATVQMLSLQHAISAVSGLHRYKIGSKRIQVSLVTGGSSKSLVMLST EIISILQDAPANCLPLFKFTEIYEKKYCRKLVVGDLYRLPEVVAVREQGGSRLVCLLPSS QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYAQQDFSEADFDPDSYKIP FVVMSLSTLASEVHSLLQSHEGTLPLLSFPDCYAAKFSPLQLGNE-TLEGGVPLEHLITC VPSITIVTAQNGFKVIKWIHNKPPAPNQTE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCIMPISKFIPSYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRDWRVIDYGICDLMDLMTEI PETTITITHHTTDTVISVPKR-ER-TVEEMERTKQFAKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDVLMVLECGEEKVLTLTEVERIKALAAQLVKLL RAQKNSSLPVCQLLTEYSKTFGYGLRLQDYDASSLPALLTKL-CHVVKVVDGLEGREVQL INRKSLRSLTSQLLALLMS------------------------------------QEEEQ VTKGL---------KVEELSHHYLTVHGAPLNPCEYGFLSLSELLKSLPYLVE------- ---V---------------------------------------------S--KEWVRLTR LYQFARNIRALLHTYHYNQLFLTEFQGAYKKFTGCSLEPRSYGYASTDELLSAIPQVVWI KGHGHKRIIVLKNDMK-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GKV--------- -----------DVSL---------------------------------------SHS--- -ISDEAAES------------------------ELLCL--TSPVDLLCGPVPSCLPSPQL HPDPVLLQ-QADLIRFEE------------------------------------------ --------------------------------RTP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GQFY--------------------------- ------------------------------------------------------------ ----------------------------------------CCISINSS------------ ----------------------FTD----------------------------------- -----------------------------------------STSDPSEQPGSTENSAVTK LPTAPNM-------------------KTPLSM---------------------------- -----------------------------------------------DSPSRRATRSRIK LAANFSFTAG-------------------------------------------L >ENSSLDP00000011081 M----------------------------------------------------ME----- ---------------R-LGKERSICSASPFPWLS-H-----------PKT-----EASTL LWKLKD---------CFSTT---------------ET---TTPHHTDKE----------- ------------------K-NYMESRKPVLELKDVPPPPP-PP----HHTS---SSQPSQ PF-SLAPL----PL---PH---------------------------PRLPP--------- ------------PPQLTQGSH-QQQ---------P-----------P--------HQQLE G----------------ATPKV--SICT-HCDYCSTD----------------------- -------------------GYGLLGGGGVVG-----------------SSSSSIAGVVSL YIAPGSVGA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PI---------------------------------------------------------- ------------------------------------------------------------ ------------------------SNSSISRSGPCSVTSSVHQYKNNLSCGREGETLDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LLSLGYKPQLPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPVSSHPYLPCCSGLLHTYPAA-------------------------- ------------------------------------------------------------ -------------PLPCSQ--PSFFPSSAPLASSLP------------------------ ---------SVSTLP-----------------------VSLHGSCLASSGYY-TCGMDCS PSA-R-RSQRS-TLGDHPTPTTI--TTTTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMHL NVER-TVCVKGAHYCQECFLK--------------------------------------- ---PMNGL-ASE----SDKIWPNVPAP--QTAPI--PIPICNGCGT---SSDSMMLMP-S TSLGKIGQKYG------SPENSGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GNHTSSALLQHAHRHVAFQEITADLPPR MLVK-------AQPSFNLLYVHNLPVNCDKSLRNAVKL---------RLRRLSDNCGGKV LG--MSQGTAVLRFGSPEAAARARKRMENEDVYGRRISLSFS------------------ ---------PRPRDDASLEPEIQSQPHHL--LQALPQPYQSQDS---------------- -----------VF----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------APP----------------- -----------------------------PSI---------------------------- --------SSFSFLP-------------------------LEK---PRSPRRPRRA---- -TR------PCHTPG-PV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPRQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELGSFEGKSRM GFHQLDKG-RAASSSPH--------------SN---------------GETGAMDQLSKP GLTGESMYRR-------------------------------------------------- ---------------------------RRE------------------------------ --------------------------GSNPRSLTESPVEQGDR----SSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLV------LSQGSW-SS--RSVSPCLSSRSSPILAAP---- -RSPC-PE---------G--PPE-PFSEGTEVQVGNLDYRMSRKDLQQTLHDTFSRYGRV KAVELSPHTDYQLKATVQMLSLQHAISAVSGLHRYKIGSKRIQVSLVTGGSSKSLAMLST EIISILQDAPANCLPLFKFTEIYEKKYCRKLVVGDLYRLPEVVAVREQGGSRLVCLLPSS QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYAQQDFSEADFDPDSYKIP FVVMSLSTLASEVHSLLQSHEGTLPLLSFPDCYAAKFSPLQLGNE-TLEGGVPLEHLITC VPSITIVTAQNGFKVIKWIHNKPPAPNQTE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCIMPISKFIPSYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRDWRVIDYGICDLMDLMTEI PETTITITHHTTDTVISVPKR-ER-TVEEMERTKQFAKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDVLMVLECGEEKVLTLTEVERIKALAAQLVKLL RAQKNSSLPVCQLLTEYSKTFGYGLRLQDYDASSLPALLTKL-CHVVKVVDGSEGREVQL INRKSLRSLTSQLLALLMS------------------------------------QEEEQ VTKGL---------KVEELSHHYLTVHAALLNPCEYGFLSLSELLKSLPYLVE------- ---LYYEEID-EDCKTGNTATDH--------------------------G--EEWVRLTR LYQFARNIRALLHTYHYNQIFLTEFQGAYKKFTGCSLEPRSYGYASTDELLSAIPQVVWI KGHGHKRIIVLKNDMK----------------ARTSS----------------------- -----SVPNS------PQ-----P-EENTETP---------------------------- -----------------------------------RGSP-------------------VS N-TFGAQS-----------------------------------P---GG----------- ------------------------------------------------------------ ---DEAAES------------------------ELLCL--TSPVDLLCGPVPSCLPSPQL HPDPVLLQ-QADLIRFEE------------------------------------------ --------------------------------RTP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PTDE------------------------------ --------------RDE------------------------------------------- ---L--------------------------------------------------EV---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --AAAAVT--------------------D------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------STEDSAVTK LPTAPNM-------------------KTPLSM---------------------------- -----------------------------------------------DSPSRRATRSRIK LAANFSFTAG-------------------------------------------L >ENSLCAP00010001349 M----------------------------------------------------ME----- ---------------G-LGKERSICSSSPFPWLI-H-----------PKT-----EASTL LWKLKD---------CFSTT---------------ET---TAPHHTDKE----------- ------------------S-NYMESRKAILELKDVPPPPP-PP----HHIS---SSQSSQ HF-SLAPL----PL---PH---------------------------PCL-P--------- ------------PPQLTQGSH-QQH---------P-----------Q--------QQQHE G----------------ASPKV--SICT-HCDYCSTD----------------------- -------------------GYGLLGGEGVVG------------------GSSSIAGVVSL YIAPGSLGA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PISS-------------------------------------------------------- ------------------------------------------------------------ -----------------------SSSSSIGRSGSCSVASSVHQYKNNLSCASGGEAFDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LLSLSYKSQLAS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPVSSHPYLPCCSGLLHTCPSA-------------------------- ------------------------------------------------------------ -------------PLPCSQ--PRLFPSPAPLASSLP------------------------ ---------SVSSLP-----------------------APLHGSCLASSGYY-TCGVDCS P-A-R-RSQRS-TPGEHPTTTTI--TTTTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMHL NVER-TVCVKGAHYCQECFLK--------------------------------------- ---PINGL-AAE----SDKVWPNVPVP--QTAPI--PIPICNGCGT---SSDGMMLMP-S TSLSKIGQKYG------SPENNGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVILVSSDVNFASELSDLRHRHGFQVILVH-GNHTSSALLQHANRHVAFQEITANLPPR MLVK-------AQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------K---PRSPRRPRRA---- -TR------PCHTPG-PV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPRQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELGSLEGKSRM GFHQLDKG-RAASSSPH--------------SN---------------GETGALEQLSKP VLTGESMYRR-------------------------------------------------- ---------------------------RRE------------------------------ --------------------------GSNPRSVTESPVEQGER----SSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLV------LSQGSWSSS--RSASPCLSSRSSPLLAAP---- -RSPC-PE---------G--PPE-PFSEGAEVQVGNLDYRMSRKDLQQTLHDTFSRYGRV KAVELSPHTDYQLKATVQMLSLQQAISAVSGLHRYKIGGKRIQVSLITGGCSKSLAMLST EIISILQDAPANCLPLFKFTEIYEKKYSRKLVVGDLYRLPEVVAVREQGGSRLVCLLPSS QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYTQQDFSEADFDPDSYKIP FVVMSLSTLASEVHSLLQSHEGTLPLLSFPDCYAAKFSPLQLGNE-TLEGGVPLEHLITC VPSITIVTAQNGFKVIKWIHNKPPAPN-SE------LWIQRCKSPVGNPQLIQFSREIID LLKSQPSCIMPISKFIPSYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRDWRIIDYGICDLMDLLTEI PDTTITITHQATDTIISVPKR-ER-TVEEMERTKQFAKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLIELFEAIPDVLMVLECGEEKVLTLTEVERIKALAAQLVKLL RAQKNSSLPVSQLLTEYSKTFGYGLRLQDYDASSLPALLTKL-CHVVKVVDGSEGRELQL INRKSLRSLTSQLLALLMS------------------------------------QEEEQ VTRGL---------KVEELSQHYLTVHGAPLNPCEYGFLSLSELLKSLPYLVE------- ---LYYEEVD-ENCKVGNTATGH--------------------------G--EEWVRLTR LYQFARNIRALLHTYHYNQIFLTEFQGAYTKFTGCSLEPRSYGYASTDELLSAIPQVVWI KGHGHKRIIVLKNDMK----------------ARTSS----------------------- -----SVPSS------PQ-----P-GDNTESP---------------------------- -----------------------------------RDSP-------------------IS NATSGAQS-----------------------------------P---GG----------- ------------------------------------------------------------ ---DLAAES------------------------ELLCL--TSPVDLLCGPVPSCLPSPQL HPDPVLLQ-QADLIHFEE------------------------------------------ --------------------------------KSP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ESDEPEVAAAAVT----------------------- ----------------------------------------GSTSDPPGQPGSTEDSALTK PPTAPNT-------------------KTPLSM---------------------------- -----------------------------------------------DSPSRRATRSKYK LAANFSFTAG-------------------------------------------L >ENSLCRP00005020666 M----------------------------------------------------ME----- ---------------G-LENERSICSSSPYPWLN-H-----------PKP-----EASTL LWKLKD---------CFSTY---------------ET---TSLHHRDKE----------- ------------------N-NYMDNRKAVLELKDVP--PP-PP----HHTS---SSQSSQ PFSSLAPL----PM---PP---------------------------PCLP---------- ------------PPQLTQDSH-QPP---------P-----------P-------PQQHQE G----------------ASPKV--SICT-QCDYCRTD----------------------- -------------------GYGLLGGGGVVG------------------SSSSVAGVVSV YMAPSSVGA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PISS-------------------------------------------------------- ------------------------------------------------------------ -----------------------------SRSDSCSVASSVHQYKHNLSCGSGGEVLDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LLSLGYKPQLLS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPISSHPYLSCCSGLLHTYPSA-------------------------- ------------------------------------------------------------ -------------PLSCSQ--PSLFTSSAPLASSLP------------------------ ---------CVSTLP-----------------------TPLHGSCLASSGYY-TCGVDCC PSA-R-RSQRS-TLGDHPTTTTI--TTTTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMHL NVER-TVCVKGAHYCQDCLLK--------------------------------------- ---PMNGL-PSE----SDKVWPNIPVP--HTAPI--PIPICNGCGT---SSDSMMLMP-S TSLGKTGQKYG------SPESSGPENIPPVGVFWDIENCSVPSGRSAAAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GNHTSSALLQHANCHVAFQEITADLPPR MLVK-------AQPSFNLLYAHNLPVNCDKSLRNAVKL---------RLRRLSDNCGGKV LG--MSQGTAVLRFGSPEAAARARKRMENEDVFGHRISLSFS------------------ ---------PRPRDDASPEPELQSRSHHLLQPQTLPQTSQNQDS---------------- -----------VF----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------APP----------------- -----------------------------PTI---------------------------- --------SSFSFLP-------------------------LEK---PRSPRRPRRT---- -TR------PCHTPG-PV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELGSLEGKPRM GFHLPEKG-RTASSSPH--------------SN---------------GETGVLDQLSKP GLTGESIYRR-------------------------------------------------- ---------------------------RRE------------------------------ --------------------------GSNPRSVNESPVEQVDR----SSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLV------LSQGSW-SS--RSASPCLSSRSSPLLTAP---- -RSPC-PE---------G--PPQ-PFSDGAEVQVANLDYRMSRKDLQQTLHDTFSRYGRV KAVELSPHTDYQLKATIQMLFLQQAISAVSGLHRYKIGGKRIQVSLITGGNNKSLAMLST EIISILQDAPANCLPLFKFTEIYEKKYSRKLVVGDLYRLPEVVAVREQGGSRLVCLLPSS LIRQSPLGSS--QSQEGSSSTSGSPVVFEELEYHEPVCRQHYTQQDFSEADFDPDSYKIP FVVMSLSTLASEVHSLLQSHEGTLPLLSFPECYAAKFSPLQLGNE-TLEGGVSLEHLITC VPSITIVTAQNGFKVIKWIHNKPPAPN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCIMPMSKFIPSYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRDWRIIDYGICDLMDLLTEI PDTTITITHQDTDTVISVPKR-ER-TVEEMERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDILMVLECGEEKVLTLTEVERIKALAAQLVKLL RAQKNSSLPVSQLLTEYSKTFGYGLRLQDYDASSLPALLTKL-CHVVKVVDGSEGREVQL INRKSLRSLTSQLLSLLMS------------------------------------QEEDQ VSNGL---------RVDVLSEQYRTVHGALLNPCEYGFLSLSELLKSLPYLVE------- ---LYHEESD-DN---------NAGVTA------GG------------RG--EDWVRLTR LYQFARNIRALLHTYHYNQIFLTEFQGAYNKFTGCSLEPRSYGYISVDELLSAIPQVVWI KGHGRKRIIVLKNDMK----------------ARASS----------------------- -----SAPNS------PQ-----P-EENMESP---------------------------- -----------------------------------RDSP-------------------VS SA-SGAQS-----------------------------------P---DG----------- ------------------------------------------------------------ ---DTASES------------------------ELLCL--TSPVDLLCGPVPSCLPSPQL HPDPILLQ-ETDLIHFEK------------------------------------------ ---------------------------------TP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PP-------------------------------- ----------------ESEPAVAAV-----------------------AGSTS------- -ELL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GSTENSAATK PPPPPDM-------------------KTPLSA---------------------------- -----------------------------------------------ESPSRRATRSRIK LAANFSFTAG-------------------------------------------L >ENSATEP00000031414 M----------------------------------------------------ME----- ---------------G-LGKERSICSSRPFPWLS-H-----------PKT-----EASNL LWKLKD---------CFSNN---------------ET---PAPHHTDKE----------- ------------------N-NCMESRKVVLELKDVP--PP-PL----HHT----SSQSSQ PF-SLAPL----PL---PP---------------------------PCM----------- ------------PPQLTQDSH-LQQ---------P-----------PS------SQQQQE G----------------AGPK--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PVSSHPYLPCCSGLLHTCPTV-------------------------- ------------------------------------------------------------ -------------RLPCSQSAASLFPSSVPLASSLP------------------------ ---------SVSSLP-----------------------APLHGSCLASSGCC-TCDLDLS SSA-R-RPQRS-TLGDHPTTTTM--TTTTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------RS--------------N-PLHL NVEH-TVMVKGAHYCQECLLK--------------------------------------- ---PVNSL-ASE----SDKVWPNVPIP--QTVPL--PVPICNGCGT---SSDNMLLMP-S TSLGNIAQKYG------SPENNGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRSYFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQIILVH-GNHTSSALLQHAHRHVAFQQITADLPPR MLVK-------AQPSFNFLYVHNLPVNCDKSLRNAVKL---------RLRRLSDNCGGKV LS--MSQGTAVLRFGSPEAAARARKRMENEDVFGHRISLSFS------------------ ---------PRPRDDASPDPELQSQHHHLPQIQTLPQPYQTQES---------------- -----------MF----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------APA----------------- -----------------------------PPV---------------------------- --------SSFSFLP-------------------------LEK---PRSPRRPQRA---- -TH------PCHTPD-PV----------LERLYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELSSLEGKTRT DFHHLDKG-QAAFASSP--------------SN---------------GEAGTLEQLSKP GLTGESMYRR-------------------------------------------------- ---------------------------RRE------------------------------ --------------------------GSSPRRVTESPVEQGDR----SSA---------- ----------------------------------------------------------EF QISTPSAFSKLNLQRSFSPLV------LSQGSW-SS--RSASPCLSSRSSPLLAAP---- -RSPC-PE---------G--PFE-PFTEGAEIQVANLDYRMSRKELQQTLHDTFSRYGRV KTVELSPHTDYQLKATIQMLSLQQAISAVSGLHRYKIGGKRIQVSLITGGSNKSLAMLSM EIISILQDAPANCLPLFKFTEIYEKKYSRKLVVGDLYRLPEVVAVREQGGSRLVCLLPSS QVRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYAQQDFSEADFDPDSYKIP FVVMSLSTLASDVHSLLHLHDGTLPLLSFPDCYAAKFSPLQLGNE-TLEGGVPLEHLITC VPSITIVTAQNGFKVIKWIHNKPPAPN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCIMPISKFIPSYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIRDFMQAYHWCFSRDWRVIDYGICDLMDLLTEI PDTTITITHQDTDTVISIPKR-ER-TVDEMERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDILMVLECGEEKVLTLTEVERIKALAAQLVKLL RAQKNSSLPVSQLLTEYSKTFGYGLRLQDYDANSLPALLTKL-CHVVKVVDGSEGREVQL INRKSLRLLTSQLLAILMS------------------------------------QEEDQ VIKGL---------KVEELSQHYLTAHGALLNPCEYGFLSLSELLKSLPYLVE------- ---LYHEESD-ENGKA---ASGH--------------------------G--EGWVRLTR LYQFARYVRALLHTYHYNQIFLTEFQGAYNKFTSCNLEPRSYGYASTDELLSAIPQVVWI KGHGHKRIIVLKNDMK----------------AKACS----------------------- -----SVPNS------PQ-----P-GENIESP---------------------------- -----------------------------------RDSP-------------------IS NETSGAQS-----------------------------------S---GD----------- ------------------------------------------------------------ ---DLAAES------------------------ELLCL--ASPVDLLCGPVPSCLPSPQL HPNPVVLQ-QADLIYFEE------------------------------------------ --------------------------------KTS------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------KSDEPEFAAAA-----------------DTACDSTE QS------------------------------------------------GSTDDSAGTK PPPTPNM-------------------KTPLSV---------------------------- -----------------------------------------------DSPSRRTTRSRIK LAANFSFTAG-------------------------------------------F >ENSSMAP00000012475 -----------------------------------------------------ME----- ---------------G-LGKERSVCRAGDFPWLSQH-----------PEP-----EASTL LWRLKD---------CFTAA---------------ET---TA----DKQ----------- ------------------N-NYMESRKAVLELKDVP--PP-PP----HRAS---SSQSSQ PF-SLAPF----PL---PH---------------------------PCLPP--------- ------------QPQLTQGSH-QQQ---------Q-----------P--------QNQQE G----------------ASPKV--SICT-HCDYCSTG----------------------- -------------------GKGLSGGGDFVG------------------NSSSTAGVVSL YIAP----------------RSLGTS---------------------------------- ------------------------------------------------------------ -------------------------ISQSSISTSG-----------------------PC SVASS--------------------VYQYSSGYSC------GSG--------------GD PLGS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------KPQLRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPVSSHPFLPCCSGLLRTYPAG-------------------------- ------------------------------------------------------------ -------------PLPCSQ--PSLFPSSAPLASSLPS-----LPS--------------- -------VSSVSSLP-----------------------APLHGSCLAPSGYY-TCGVDCS PSA-R-RSQRS-TLGDHSTPTTF--TTTTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMHL NVER-TVCVKGAHYCRECFLK--------------------------------------- ---PLNGL-ASD----SDKAWPNIPVP--QTAPV--PIPICNGCGT---SSDGMMHMP-S TGLSKIGQKYG------SPENGGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GNHTSSALLQHAHRQVAFQEITADLPPR MLVK-------AQPSFNLLYVHNLPVIVDKSLRNAVKL---------RLRRLSDNCGGKV LG--MSQGTAILRFGNPEAAARARKRMENEDVFGHRISLSFS------------------ ---------PRPRDDASPEPELQSQPHHL--PRAPPQPYQIQDS---------------- -----------MS----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------APP----------------- -----------------------------PSI---------------------------- --------SSFSFLP-------------------------LEK---PRSPRRPRRA---- -TR------PCLTPG-PV----------PERPYSPRRV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELGNLEGKSRM GFHQLEKG-RAASSSPH--------------SN---------------GETGILEQLSKP GLAGESMYRR-------------------------------------------------- ---------------------------RRE------------------------------ --------------------------GFNPRSVTVSPVEQGDK----SSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLV------LSQGSW-SS--RSASPCISSRSSPVLAAP---- -RSPC-LE---------G--PTE-PFSEGAEVQVGNLDYRMSRKDLQQTLHDTFSRYGRV KAVELSPHTDYQLKATVQMLSLQQAISAVSGLHRYKIGGKRMQVSLITGGSSKSLAMLSS EIICILQDAPASCLPLFKFTEIYEKKYSRKLAVGDLYRLPEVVTVREQGGSRLVCLLPSS QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYAQQDFSEADFDPDSYKIP FVVMSLSTLATEVHSLLQSHEGTLPLLSFPECYAAKFCPLQLGSE-TMEGGVSLEHLITC VPSITIVTAQNGFKVIKWIHNKPPAPN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCIMPISKFIPSYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVSIKDFMQAYHWCFSRDWRVIDYGICDLMDLLTEI PETTITITQQATDTVISVPKR-ER-TMEEMERTKQFAKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDVLMVLECGEEKVLTLTEVERIKALAAQLVKLL RAQRNASLPVGLLLTEYSKTFGYGLRLQDYDASSLPALLTKL-CHVVKVVDGSEGREVQL INRKSLRSLTSQLLALLMS------------------------------------QEEEQ VTKGL---------KVEELSQRYLTAHEVALNPCEYGFLSLSELLKSLPYLVE------- ---LYHEEID-ENSKAVNTAT----------------------------G--EEWVRLTR LYQFARNIRALLHTYHYNQIFLTEFQGAYNKFTGCSLEPRRYGYASNDELLSAIPQVVWI KGHSHKRIIVLKNDMK----------------ARTGS----------------------- -----SVPSS------PQ-----P-G---------------------------------- ------------------------------------------------------------ --------------------------------------------------GNTGRLRDDP VSSTNSRAQSPDV----------------------------------------------- ---DVAAES------------------------ELLCL--TSPVDLLCGPVPSCLPSPQL HPDPVLLQ-QADLIHFEW------------------------------------------ --------------------------------KTS------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------EVDEFEVAAAAAVVGGTADPLEEPGSVD ESAVTKP----------------------------------------------------- PSMMKTP--------------------------------LC------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------DSPSRRAARSRIK LAANFSFTAG-------------------------------------------L >ENSPRNP00000000010 -----------------------------------------------------MD----- ---------------G-LEKERSLCSSRPFPWLS-------------PRT-----EASTL LWKLKD---------CFSSD---------------ET---TSPHQTQTE----------- ------------------S-NHMDNRKAVLDLKDVP--PPLPP----HHAS---SSHSAQ PF-SLAPL----PL---PP---------------------------PCLPP--------- ------------PPQLTQDSH-QQQSSPP----PP-----------P-------QQQHQK G----------------ASPKV--SICT-HCDYCSAA----------------------- -------------------SYRSLGGSGVVG------------------SSSSVAGVVSL YMTPDSLGA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PSST-------------------------------------------------------- ------------------------------------------------------------ -----------------------------SRHGPYSVASSVHQFNHNISCGTGREVYNP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LLNLGCKPQLPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPLSSHPYLPCCSGLLHTYPAA-------------------------- ------------------------------------------------------------ -------------PLACSQ--SSPFPSSAPLASSLP------------------------ ---------SVSNLP-----------------------APLHGSCLTSSGFY-TCGVDCT PSS-R-RPQRS-ILGDHPSTSTI--TTTTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMHL NVER-TVCVKGAHFCQECLLK--------------------------------------- ---PMNGL-TSE----TDKVWPNVPIP--PTAPI--PVPVCNGCGT---SSDGM--APKS TSLSKSGQKYG------SPESSGPENIPPVGVFWDIENCSVPTGRSAGAVVKRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRYRHGFQVILVH-GSHVSSALLQHAHHHVPFQEMTADLPPR VLGK-------AQPSFNLLYVHNLPLNCDKSLRNAVKL---------RLRRLSDNCGGKV LG--MAQGTAVLRFGSPEAAARARKRMENEDVFGHRISLSFS------------------ ---------PRPRDNASPEPELQSYPHRL--HQTLPQTYQTQDA---------------- -----------MI----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------APP----------------- -----------------------------PSI---------------------------- --------SSFSFLP-------------------------LEK---PRSPRRPRRA---- -SR------PCHTPG-PV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------EVGSLEVKPKL GIHYLEKG-RTASSSPH--------------SN---------------GEAGTLEQLSKP GLTGESIYRR-------------------------------------------------- ---------------------------RRE------------------------------ --------------------------GSNPRSAIESPVEHGDR----SSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLQRSFSPLI------LSQGSW-SS--RSASPCLSSRSSPLLATP---- -RSPC-PE---------G--PPE-PYSEGAEVQVANLDYRMSRKDLQQTLHDTFSRYGRV KAVELSPHTDYQLKATVQMLSLQQAISAVSGLHRYKIGGKRIQVSLSTGGSSKSLALLST EIICILQDAPANCLPLFKFTEIYEKKYSRKLVIGDVYRLPEVVAVREQGGSRLVCLLPNN QIRQSPLGSS--QSQEG-SSASGSPVVFEELEYHEPVCRQHYSQQDFSEADFDPDSYKIP FVVMSLSTLASEVHSLLQSHEGTLPLLSFPDCYAAKFSPLQLGNE-TLEGGVPLEHLITC VPSITIVTAQNGFKVIKWIHNKPPAPN-SE------PWVQRCKSPVGNPQLIQFSREIID LLKNQPSCIMPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRDWRVVDYGTCDLMDLLAEI PDTTITITHQATDTVISVPKR-ER-TVEEMERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPEVLMVLECGEEKVLTLTEVERIKALAAQLVKLL RAQKNSSLPVSELLTEYSKTFGYGLRLQDYDASSLPALLTKL-CHVVKVVDGSEGREVQL INRKSLRSLTSQLLALLMS------------------------------------QEDDQ VTSGL---------KVEELSQHYHTVHRAVLNPCEYGFLSLSELLKSLPYLVE------- ---LYHEESD-ENS---NTTSPY--------------------------G--EEWVRLTR LYQFARNIRGLLHTYHYNQIFLTEFQGAYSKFSGCSLEPRSYGYTSIDELLSAIPQVVWI KGHGHKRIIVLKNDMK----------------AKASC----------------------- -----SVPSS------PQ-----P-G-TTESP---------------------------- -----------------------------------RDSP-------------------IS TATSGAQS-----------------------------------P---VV----------- ------------------------------------------------------------ ---DASAES------------------------ELLCL--TSPVDLLCGPVPSCLPSPQL HPDPVSLK-DADLIHFEE------------------------------------------ --------------------------------RTP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P--------------------------------- ------------------------------------------------------------ -------------------------------------------------------LP--- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PIESAEPEVAAADSTAHPPEQPDSAATH TPAA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----PDV-------------------KPPLTT---------------------------- -----------------------------------------------ESPNRRASRSRFR LAANFSFTAG-------------------------------------------L >ENSMAMP00000012547 M----------------------------------------------------ME----- ---------------G-LGEERSICSSRPFPWLS-H-----------PKT-----EASTL LWKLKD---------CFSTN---------------ET---TAPHHTDKE----------- ------------------T-NYMESRKAVLELKDV---PP-PP----HHTS---SSQSSQ PY-SLAPL----PL---PP---------------------------PCLP---------- ------------PPQLTQDSH-QQQ---------P-----------P-------PQQRQE G----------------ASSKV--SICT-RCDYCSTD----------------------- -------------------VYGLLGGGGVVGSS----SSSSSSSSSSSSSSSSVAGVVSL YMAPGSLGA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PI---------------------------------------------------------- ------------------------------------------------------------ ------------------------SSSCINRSGPCSVASSVHPYK-------------PK ------P----------------------------------------------------- ----SCGS---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EVPDTLLGLSYKPQLPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPVSSHPYLTCCSGVLHTFPSV-------------------------- ------------------------------------------------------------ -------------SHPCSQ--PNLFPSSTSVVSSIP------------------------ ---------SVSSLP-----------------------APLHGSCLASSGYY-TCGVDCS PSA-R-RSQRG-TLGD-PPTTAI--TTTTT------------------------------ ------------------------------------------------------------ ---------STHF----------------------------------------------- --------------------------------------CS--------------N-PVHL NVQR-TLFVKGAHYCQECLLK--------------------------------------- ---PVNGL-SSE----SDSVWPNVPIP--QTATL--PIPICNGCGT---SSDGMVLMP-S TSLGNSGQKYG------SPENNGPENLPPVGVFWDIENCSVPSGRSAGAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GNHTSSALLQHAHRHVAFQDITADLPPR MLVK-------AQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------K---PRSPRRPRRA---- -TR------PCHTPG-PV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELGSLEDKPRM DFQHLDKG-RAAAFPPN--------------SN---------------GETGTPEQLSKP GLTGESIYRR-------------------------------------------------- ---------------------------RRE------------------------------ --------------------------GSSPRTVTESPAEQGDR----SSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLV------LSQGSW-SS--RSVSPCLSSRSSPLLTAP---- -RSPC-SE---------G--PFE-LFSEGAEIQVANLDYRMSRKDLQQTLQDTFSRYGRV KAVELSPHTDYQLKATVQM-SLQQAISAVSGLHRYKVGGKRIQVSLVTSGSSKSLAMLSS EIISILQDAPANCLPLFKFTDIYEKKYSRKLVVGDLYRLPDLVAVREQGGSRLVCLLPNS QIRQSPLGSS--QSQEGSSSTSGSPVVFEELEYHEPVCRQHYAQQNFSEADFDPDSYKIP FVVMSLTTLASEVHSLLQSHEGTLPLLSFPDCYAAKFSPLQVGSE-TLEGGVPLEHLITC VPSITIVTAQNGFKVIKWIHNKPPAPN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCIMPISKFIPSYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVALKDFMQAYHWCFSRDWRVTDYGMCDLMDLLTEI PDSTITIAHQDTDTVISVPKR-ER-TVEEMERTRQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDVLMVLECGEEKVLTLTEVERIKALAAQLVKLL RAQKNSSLPVSQLLTEYSKTFGYGLRLQDYDASSLPALLTKL-CHVVKVVDGSEGREVQL INRKSLRLLTSQLLALLMS------------------------------------QEEEQ VISGL---------KVEELSQQYLTVYGALLNPCEYGFLSLSELLKSLPYLVE------- ---LYHDETD-ENNKAGSTQSGQ--------------------------G--EGWVRLTR LYQFARNLRALLHTYHYNQIFLTEFPGAYHKFMGHILEPRSYGYANTDELLSAVPQVVWI KGHGHKRIIVLKNDMK----------------ARASS----------------------- -----SVPNS------PQ-----P-GGNTESP---------------------------- -----------------------------------RDSP-------------------MS SM-SGGQS-----------------------------------SDNTGG----------- ------------------------------------------------------------ ---DVATES------------------------ELMCL--ASPVDLLCGPVPSCLPSPQL HPDPVLLQ-QTDLIHFED------------------------------------------ --------------------------------NTP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PK-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ENDEPEVAAAAVTDT----TSAPPDGS--------- --------------------------------------------------GNTDNSTGPK PPPAPDT-------------------KAPLSI---------------------------- -----------------------------------------------GSPSRRATRSKIR LAPNFSFTAG-------------------------------------------L >ENSMALP00000003600 M----------------------------------------------------ME----- ---------------G-LEKERSIRSFRPFAWPS-H-----------PKT-----EAPTL LWKLKD---------CFSTN---------------ET---TAPPHTDTE----------- ------------------N-SYMESRKAVLELKDVPPPPP-PP----HHTSISQSSQPSQ PF-SLAPL----PL---PP---------------------------ACLP---------- ------------PPQLTQDSH-QQK---------P-----------P-------PKHQQE G----------------PSPKV--SNCT-HCDYCSTD----------------------- -------------------VYGLLGGGGVAG------------------SSSSIAGVVSL YTSPGSLGA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PV---------------------------------------------------------- ------------------------------------------------------------ ------------------------STCTISRCGPCSLASS-------------------- ------------------------------------------------------------ -------SA------------------HRYKPNLSH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------RSGGDAPNPLLSLGYKPQLPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPLSSHPYLPCCSGLLHTHPSV-------------------------- ------------------------------------------------------------ -------------QHPYSQ--SSLFPSSAPPAFSLP------------------------ ---------CFSSQP-----------------------APLNDSCLASSGYY-TCGVDCS TAA-R-RSQRS-TFGDHPTTTTI--TTTTT------------------------------ ------------------------------------------------------------ ---------SAQF----------------------------------------------- --------------------------------------CS--------------N-PVHL NVER-TVFVKGAHYCKECLLK--------------------------------------- ---PVNGL-TSE----SDNVWPSVPLP--QTTPL--PIPICNGCGT---SSDGMVLMP-M TNLGNTGQKYG------SPENSGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GNHTSPALLQHAHRHVAFQDITADLPPR MLVK-------SQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------TRSPRRPRRA---- -TR------PCHTPG-PL----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGPPAKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELCSLDGKPRI DFHHLDKG-RAASSPPH--------------SN---------------CETGTSEQLSKP VLAGESMYKR-------------------------------------------------- ---------------------------RRE------------------------------ --------------------------GSNPRSVTESPVEQGDR----SSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLV------LSQGSW-SS--RSASPCLSSRSSPLLAAP---- -RSPC-PE---------G--PFD-LFSERAEVQVANLDYRMSRKDLQKTLHDTFSRYGRV QAVELSPHTDYQLKAIVQMLSLQQAIRAISGLHRYKIGGKRIRVSLITSGSSKSLAMLST EIISILQDAPANCLPLFKFTEIYEKKYSHKFVVGDLYRLPEVVAVREQGGSRLVCLLSSS QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYTQQNFSEADFDPDSYKIP FVVMSLSTLASEVHSLLQSHEGTLPLLSFPDCYAAKFSPLQLGNE-TLEGGVPLEHLITC VPSITIVTAQNGFKVIKWIHNKPPAPN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCIMPISKFIPSYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIRDFMQAYHWCFSRDWRVIDYGVCDLMDLLAEI PDTTITIMHQDTDTVICVPKR-ER-TAEEIERTKQFGKEVVDLLRHQPHCRMSFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDVLMVLECGEEKLLTLTEVERIKALAAQLVKLL RAQKNSSLPVSQLLTEYSKTFGYGLRLQDYDASSLPALLTKL-RHVVKVVDGSEGREVQL INRKSLRSLTSQLLALLMS------------------------------------QEEEH VIKGL---------KVEELSQHYQSVHGASLNPCEYGFLSLSELLKSLPYLVE------- ---LYHEEIN-ENSNTGSTASGQ--------------------------G--EGWVRLTR LYQFARNVRALLHTYHYNQIFLTEFPGAYNKFTGYSLEPRSYGYASTDELLSAIPQVVWI KGHGHKRIIVLKNDMK----------------AKASL----------------------- -----SIPNS------PQ-----P-EENTESP---------------------------- -----------------------------------RDSP-------------------VS NATSVARS-----------------------------------PSNTGD----------- ------------------------------------------------------------ ---DVATES------------------------ELLCL--TSPVDLLCGPVPSCLPSPQL HPDPVILQ-QMDLIHFEE------------------------------------------ --------------------------------KAP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ESDEPDVAAAAVTGSIFTPT---------------- -----------------------------------------------EQPGSTDNSAGTK HPQAPDM------------------KKIPSSV---------------------------- -----------------------------------------------DSPSRRGTRSKIR LAANFS---G-------------------------------------------L >ENSLBEP00000035700 M----------------------------------------------------ME----- ---------------G-LGNDTFICSSRALPCLS-H-----------PKT-----EPSTL LWKLKD---------CFSTN---------------ET---NSLRHTDKE----------- ------------------N-NYMDSRKAVLELKDV---PP-PP----QHTS---SSQLSQ PF-SLVPL----PL---PP---------------------------PCLP---------- ------------PPQLTQDSH-QQQ---------P-----------P-------PQQQQE G----------------ASPKVRPQVCS-HCDYCSTD----------------------- -------------------SYGLLGGGGVVG------------------SSSSIAGVVSL YMDPGSLGA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PIS--------------------------------------------------------- ------------------------------------------------------------ ------------------------SSSNIGRSGLCSVTSSVHQYKRNLSCGRAGEVLDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LLGLDYKPQPLS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------NVATSQPISSHPYLSCCSGILHATPSV-------------------------- ------------------------------------------------------------ -------------PLPCSQ--PSLFPSFPPLASSLP------------------------ ---------CVSSLP-----------------------APLHGSCLASSGYY-PC-VDCC PSA-R-RTQRS-TPCDHPTTTTI--TTTTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PVHL NVER-TVCVKGAHFCQECLLK--------------------------------------- ---PLNGLAVSE----SDTVWHNVPVP--QTAPI--PIPICNGCGT---SSDGMMLMS-S TSLGKTGQKYG------SPETCGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINAIAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GNHTSSALLQHAHCHVAFQEITADLPPR ILIK-------EQPSFNLLYVHNLPINCDKNLRNAVKL---------RLRRLSDNCGGKV LG--MSQGTAVLRFGNPDAAARARKRMENEDVFGRRISLSFS------------------ ---------PHPRDDTSPEPELQSRTHLLPQPQALPQTYQNQDS---------------- -----------MF----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------TPT----------------- -----------------------------PSV---------------------------- --------SSFSFLP-------------------------LEK---PRSPRRPRRA---- -TR------PYNTPG-PV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPDKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELGSLECKPRT GLHHLERG-RAVSSSPH--------------SN---------------GETGSLERLSKP GLAGESMYRR-------------------------------------------------- ---------------------------RRE------------------------------ --------------------------GSNPCTVTVSSGEQGDK----SSG---------- ----------------------------------------------------------DF QMSTPSAFSKLNLHRSFSPLA------LSQGSW-SS--RSVSPCLSSRSSPLLAAP---- -RSPH-PD---------R--PPE-PFSDGAEIQVANLDYRMSRKDLQQTLRDTFFRYGQV KAVELSPHTDYQLKATIQMLSLQQAISAISGLHRYKIGGKRIQVSLITGGSSKSLAMLST EIITILQDAPANCLPLFKFTEIYEKKYSRKLVVGELYKLPEVVAVREQGGSRLVCLLPSS QVRQSPLGSS--QSQEGSSSASGSPVVFEELEYHDPVCRQHY-KQDFSEADFDPDSYKIP FVVMSLNTLASEIHSLLQSHQGTLPLLSFPDCYAAKFSTLQLGNE-TLEGGVPLEHLITC VPSITIVTAQNGFKVIKWIHNKPPAPN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKNQPSCIMPMSKFIPSYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVSIDDFMQAYHWCFSRDWRVVDYGICDLMDLLTEI PDTTITITHQDKDTVISVPKR-ER-TIEEMDRTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDILMVLECGEEKVLTLTEVERIKALAAQLVKLL RAQKNSSLPVSQLLTEYSKTFGYGLRLQDYDASSLPALLTKL-CHVVKVVDGAEGREVQL INRKSLRSLTSQLLSLLMS------------------------------------QDGQQ VTKGF---------KVEVLSQQYLTVYGASLNPCEYGFLSLSELLKSLPYLVE------- ---LYHEESE-DN-----TSSGR--------------------------G--EEWVRLTW LYQFARNVRALLHTYHYNQLFLTEFLGAFNKFTGASLEPRSYGYISIDELLGAIPQVVWI KGHGHKRIIVLKNDMK----------------ARATS----------------------- -----SVPTS------PL-----P-GENTDSP---------------------------- -----------------------------------RDSP-------------------IS ISTSGAQS-----------------------------------P---GG----------- ------------------------------------------------------------ ---DAVADS------------------------ELLCL--TSPVDLLCGPVPSCLPSPQL HPDPVLLQ-QTDLIHFEE------------------------------------------ --------------------------------KSP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------TTQTPVSDEPEVA DADGTSDAPEHPAFIGDSAVSNF------------------------------------- ------------------------------------------------------------ -PPPPDM-------------------KTNLSM---------------------------- -----------------------------------------------DSPSRRVTRSRIK LAANFSFPAG-------------------------------------------L >ENSACLP00000023800 M----------------------------------------------------ME----- ---------------G-LGKERSTCGARSFPWLA-H-----------TET-----EASTL LWKLKD---------CFSAH---------------ET---SSPHQTDK------------ ------------------S-NHMDNRKAVLDLKDVP--PP-PL----HHTS---SSQLSQ PF-SLSSL----PL---PP---------------------------PCLPPP-------- ------------PPQLAQDSF-QQP---------P-----------P-------PHQQQE G----------------ASPKV--SICE-HCDHNNTD----------------------- -------------------GFGLLGGRGVVG------------------SGSNAAGVVSL YMAPGSLGA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PIST-------------------------------------------------------- ------------------------------------------------------------ -----------------------------SRSGPCSVASSVHQYKHKFSCGTGGEAFDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LFSLSCKPQLSS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPISSHPYLPCCSGLLHTYPAV-------------------------- ------------------------------------------------------------ -------------PLSFSQ--ASLFPSSAPMASSLP------------------------ ---------SVSSLP-----------------------ASLHGSCLTSSGFY-TCGVDCS ASA-R-RSQGS-ILGGHPSTSTI--TTTAT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------FS--------------N-PMHL NVER-TVCVKGAHYCQECLFK--------------------------------------- ---PMNGL-MAE----SDKVYPSVPIP--QTAPI--PIPICNGCGT---FSDGKMLMP-S TSLGKTGQKYG------SPEGTGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRNRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFHVILVH-GSHTSSALLQHANSHVPFQEITADLPPR MLVK-------AQPSFNHLYVHNLPLNCDKNMRNAVKL---------RLRRLSDNCGGRV LG--VSQGTAVLRFGSPEAATRARKRMENEDVFGHRISLSFS------------------ ---------PRPRDDASPESELRSQPHHL--PQTLTRTSQTQDS---------------- -----------MF----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GPP----------------- -----------------------------PSI---------------------------- --------ASFSFLP-------------------------LET---PRSPRRPRRA---- -TR------PCHTPG-PV----------AERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELGSLEGKARM NFQHLEKG-CAASSSTQ--------------NN---------------GEAGALEQLTKP GLTVESIYSQ-------------------------------------------------- ---------------------------SRE------------------------------ --------------------------DSSPQSATESPVDQVDR----NSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLV------LSQGSW-SS--RSASPCLSSRSSPLIAAP---- -RSPC-SE---------A--S-E-PFSEGAEIQVANLDYRMSRKDLQQTLNDTFSRYGRV KSVELSPHTDYQLKATIQMMSLQQAISAVSGLHRYKIGGKRIQVSLITGGSNKSLAMLGP EIISILQDAPASCLPLFKFTDIYEKKYSRKLVVGDLYRLPELVAVREQGGSRFVCLLSNS QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYSLQDFSEADFDPDSYKIP FVVMSLSTLASEVHSLLQSHQGTLPLLSFPDCYAAKFRPLQLGNE-SLEGGVPLEHLVTC VPSITVVTAQNGFKVIKWINNKPPVPN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCIMPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRDWRVTDYGICDLMDLLTEI PDTTITITQQPTDTVISVPKR-ER-TMEELERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSHYGFTKLIELFEAIPDVLMVLECGEEKVLSLTEVERIKALAAQLVKLL RAQKNSSLPVSQLLTEYSKTFGYGLRLQDFDASSLPALLTKL-CHVVKVVDGADGREVQL INRKSLRSLTSQLLALLMS------------------------------------QEDEN ITKGL---------KVEELSQYYLSVHGVALNPCEYGFLSLSELLKSLPYLVE------- ---LYHEETD-DTT---QAASSH--------------------------W--EEFVRLTR LYQFARNVRALLHTYHYNQIFLTEFHGAYNKFTGCSLDPRFCGYTSVDELLSAIPQVIWI KGHGHKRIIVLKNDMK----------------AKPSC----------------------- -----SVSNS------PQ-----L--ENTESP---------------------------- -----------------------------------RDSP-------------------IS SATSGAQS-----------------------------------P---GA----------- ------------------------------------------------------------ ---DAAAES------------------------ELLCL--SSPVDLLCGPVPSCLPSPQL HPDPVVVQ-QADLIYFEE------------------------------------------ --------------------------------RTP------------------------- ------------------------PL---------------------------------- ------------------PT---------------------------------------- ------------------------------------------------------------ ---------------------------------------------DVTADLPAKRDGSTD DSA----------------------DP--------------------------------- --------------R--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E PPPPPDT-------------------KTLLSM---------------------------- -----------------------------------------------DSPSRRASRSRIK LAANFSFTAG-------------------------------------------L >ENSPNYP00000007101 M----------------------------------------------------ME----- ---------------G-LGKERSTCGARSFPWLA-H-----------TET-----EASTL LWKLKD---------CFSAH---------------ET---SSPHQTDK------------ ------------------S-NHMDNRKAVLDLKDVP--PP-PL----HHTS---SSQLSQ PF-SLSSL----PL---PP---------------------------PCLPPP-------- ------------PPQLAQDSF-QQP---------P-----------P-------PHQQQE G----------------ASPKV--SICE-HCDHNNTD----------------------- -------------------GFGLLGGRGVVG------------------SGSNAAGVVSL YMAPGSLGA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PIST-------------------------------------------------------- ------------------------------------------------------------ -----------------------------SRSGPCSVASSVHQYKHKFSCGTGGEAFDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LFSLSCKPQLSS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPISSHPYLPCCSGLLHTYPAV-------------------------- ------------------------------------------------------------ -------------PLSFSQ--ASLFPSSAPMASSLP------------------------ ---------SVSSLP-----------------------ASLHGSCLTSSGFY-TCGVDCS ASA-R-RSQGS-ILGGHPSTSTI--TTTAT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------FS--------------N-PMHL NVER-TVCVKGAHYCQECLFK--------------------------------------- ---PMNGL-MAE----SDKVHPSVPIP--QTAPI--PIPICNGCGT---FSDGKMLMP-S TSLGKTGQKYG------SPEGTGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRNRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFHVILVH-GSHTSSALLQHANSHVPFQEITADLPPR MLVK-------AQPSFNHLYVHNLPLNCDKNMRNAVKL---------RLRRLSDNCGGRV LG--VSQGTAVLRFGSPEAATRARKRMENEDVFGHRISLSFS------------------ ---------PRPRDDASPESELRSQPHHL--PQTLARTSQTQDS---------------- -----------MF----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GPP----------------- -----------------------------PSI---------------------------- --------ASFSFLP-------------------------LET---PRSPRRPRRA---- -TR------PCHTPG-PV----------AERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELGSLEGKARM NFQHLEKG-CAASSSTQ--------------NN---------------GEAGALEQLTKP GLTVESIYSQ-------------------------------------------------- ---------------------------SRE------------------------------ --------------------------DSSPQSTTESPVDQVDR----NSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLV------LSQGSW-SS--RSASPCLSSRSSPLIAAP---- -RSPC-SE---------A--S-E-PFSEGAEIQVANLDYRMSRKDLQQTLNDTFSRYGRV KSVELSPHTDYQLKATIQMMSLQQAISAVSGLHRYKIGGKRIQVSLITGGSNKSLAMLGP EIISILQDAPASCLPLFKFTEIYEKKYSRKLVVGDLYRLPELVAVREQGGSRFVCLLSNS QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYSLQDFSEADFDPDSYKIP FVVMSLSTLASEVHSLLQSHQGTLPLLSFPDCYAAKFRPLQLGNE-SLEGGVPLEHLVTC VPSITVVTAQNGFKVIKWINNKPPVPN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCIMPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRDWRVTDYGICDLMDLLTEI PDTTITITQQPTDTVISVPKR-ER-TMEELERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSHYGFTKLIELFEAIPDVLMVLECGEEKVLSLTEVERIKALAAQLVKLL RAQKNSSLPVSQLLTEYSKTFGYGLRLQDFDASSLPALLTKL-CHVVKVVDGADGREVQL INRKSLRSLTSQLLALLMS------------------------------------QEDEN ITKGL---------KVEELSQYYLSVHGVALNPCEYGFLSLSELLKSLPYLVE------- ---LYHEETD-DTT---QAASSH--------------------------G--EEFVRLTR LYQFARNVRALLHTYHYNQIFLTEFHGAYNKFTGCSLDPRFCGYTSVDELLSAIPQVIWI KGHGHKRIIVLKNDMK----------------AKPSC----------------------- -----SVSNS------PQ-----P--ENTESP---------------------------- -----------------------------------RDSP-------------------IS SATSGAQS-----------------------------------P---GA----------- ------------------------------------------------------------ ---DAAAES------------------------ELLCL--SSPVDLLCGPVPSCLPSPQL HPDPVVVQ-QADLIHFEE------------------------------------------ --------------------------------RTP------------------------- ------------------------PL---------------------------------- ------------------PT---------------------------------------- ------------------------------------------------------------ ---------------------------------------------DVTADLPAKRDGSTD DSA----------------------DP--------------------------------- --------------R--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E PPPPPDT-------------------KTLLSM---------------------------- -----------------------------------------------DSPSRRASRSRIK LAANFSFTAG-------------------------------------------L >ENSHBUP00000033956 M----------------------------------------------------ME----- ---------------G-LGKERSTCGARSFPWLA-H-----------TET-----EASTL LWKLKD---------CFSAH---------------ET---SSPHQTDK------------ ------------------S-NHMDNRKAVLDLKDVP--PP-PL----HHTS---SSQLSQ PF-SLSSL----PL---PP---------------------------PCLPPP-------- ------------PPQLAQDSF-QQP---------P-----------P-------PHQQQE G----------------ASPKV--SICE-HCDHNNTD----------------------- -------------------GFGLLGGRGVVG------------------SGSNAAGVVSL YMAPGSLGA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PIST-------------------------------------------------------- ------------------------------------------------------------ -----------------------------SRSGPCSVASSVHQYKHKFSCGTGGEAFDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LFSLSCKPQLSS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPISSHPYLPCCSGLLHTYPAV-------------------------- ------------------------------------------------------------ -------------PLSFSQ--ASLFPSSAPMASSLP------------------------ ---------SVSSLP-----------------------ASLHGSCLTSSGFY-SCGVDCS ASA-R-RSQGS-ILGGHPSTSTI--TTTAT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------FS--------------N-PMHL NVER-TVCVKGAHYCQECLFK--------------------------------------- ---PMNDL-MVE----SNKVHPSVPIP--QTA----PIPICNGCGT---FSDGKMLMP-S TSLGKTGQKYG------SPEGTGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRNRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFHVILVH-GSHTSSALLQHANSHVPFQEITADLPPR MLVK-------AQPSFNHLYVHNLPLNCDKNMRNAVKL---------RLRRLSDNCGGRV LG--VSQGTAVLRFGSPEAATRARKRMENEDVFGHRISLSFS------------------ ---------PRPRDDASPDSELRSQPHHL--PQTLARTSQTQDS---------------- -----------MF----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GPP----------------- -----------------------------PSI---------------------------- --------ASFSFLP-------------------------LET---PRSPRRPRRA---- -TR------PCHTPG-PV----------AERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELGSLEGKARM NFQHLEKG-CAASSSTQ--------------NN---------------GEAGALEQLTKP GLTVESIYSQ-------------------------------------------------- ---------------------------SRE------------------------------ --------------------------DSSPQSATESPVDQVDR----NSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLV------LSQGSW-SS--RSASPCLSSRSSPLIAAP---- -RSPC-SE---------A--S-E-PFSEGAEIQVANLDYRMSRKDLQQTLNDTFSRYGRV KSVELSPHTDYQLKATIQMMSLQQAISAVSGLHRYKIGGKRIQVSLITGGSNKSLAMLGP EIISILQDAPASCLPLFKFTEIYEKKYSRKLVVGDLYRLPELVAVREQGGSRFVCLLSNS QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYSVQDFSEADFDPDSYKIP FVVMSLSTLASEVHSLLQSHQGTLPLLSFPDCYAAKFRPLQLGNE-SLEGGVPLEHLVTC VPSITVVTAQNGFKVIKWINNKPPVPN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCIMPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRDWRVTDYGICDLMDLLTEI PDTTITITQQPTDTVISVPKR-ER-TMEELERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSHYGFTKLIELFEAIPDVLMVLECGEEKVLSLTEVERIKALAAQLVKLL RAQKNSSLPVSQLLTEYSKTFGYGLRLQDFDASSLPALLTKL-CHVVKVVDGADGREVQL INRKSLRSLTSQLLALLMS------------------------------------QEDEN ITKGL---------KVEELSQYYLSVHGVALNPCEYGFLSLSELLKSLPYLVE------- ---LYHEETD-DTT---QAASSH--------------------------G--EEFVRLTR LYQFARNVRALLHTYHYNQIFLTEFHGAYNKFTGCSLDPRFCGYTSVDELLSAIPQVIWI KGHGHKRIIVLKNDMK----------------AKPSC----------------------- -----SVSNS------PQ-----P--ENTESP---------------------------- -----------------------------------RDSP-------------------IS SATSGAQS-----------------------------------P---GA----------- ------------------------------------------------------------ ---DAAAES------------------------ELLCL--SSPVDLLCGPVPSCLPSPQL HPDPVVVQ-QADLIHFEE------------------------------------------ --------------------------------RTP------------------------- ------------------------PL---------------------------------- ------------------PT---------------------------------------- ------------------------------------------------------------ ---------------------------------------------DVTADLPAKRDGSTD DSA----------------------DP--------------------------------- --------------R--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E PPPPPDT-------------------KTLLSM---------------------------- -----------------------------------------------DSPSRRASRSRIK LAANFSFTAG-------------------------------------------L >ENSMZEP00005013171 -----------------------------------------------------ME----- ---------------G-LGKERSTCGARSFPWLA-H-----------TET-----EASTL LWKLKD---------CFSAH---------------ET---SSPHQTDK------------ ------------------S-NHMDNRKAVLDLKDVP--PP-PL----HHTS---SSQLSQ PF-SLSSL----PL---PP---------------------------PCLPPP-------- ------------PPQLAQDSF-QQP---------P-----------P-------PHQQQE G----------------ASPKV--SICE-HCDHNNTD----------------------- ------------------------------------------------------------ ----GSLGA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PIST-------------------------------------------------------- ------------------------------------------------------------ -----------------------------SRSGPCSVASSVHQYKHKFSCGTGGEAFDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LFSLSCKPQLSS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPISSHPYLPCCSGLLHTYPAV-------------------------- ------------------------------------------------------------ -------------PLSFSQ--ASLFPSSAPMASSLP------------------------ ---------SVSSLP-----------------------AT-------------------- -----------------------------T------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------FS--------------N-PMHL NVER-TVCVKGAHYCQECLFK--------------------------------------- ---PMNGL-MAE----SDKVHPSVPIP--QTAPI--PIPICNGCGT---FSDGKMLMP-S TSLGKTGQKYG------SPEGTGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRNRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFHVILVH-GSHTSSALLQHANSHVPFQEITADLPPR MLVK-------AQPSFNHLYVHNLPLNCDKNMRNAVKL---------RLRRLSDNCGGRV LG--VSQGTAVLRFGSPEAATRARKRMENEDVFGHRISLSFS------------------ ---------PRPRDDASPESEL-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------PSFSFLP-------------------------LET---PRSPRRPRRA---- -TR------PCHTPG-PV----------AERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------LGSLEGKARM NFQHLEKG-CAASSLTQ--------------NN---------------GEAGALEQLTKP GLTVESIYSQ-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------R----NSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLV------LSQGSW-SS--RSASPCLSSRSSPLIAAP---- -RSPC-SE---------A--S-E-PFSEGAEIQVANLDYRMSRKDLQQTLNDTFSRYGRV KSVELSPHTDYQLKATIQMMSLQQAISAVSGLHRYKIGGKRIQVSLITGGSNKSLAMLSP EIISILQDAPASCLPLFKFTEIYEKKYSRKLVVGDLYRLPELVAVREQGGSRFVCLLSNS QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYSLQDFSEADFDPDSYKIP FVVMSLSTLASEVHSLLQSHQGTLPLLSFPDCYAAKFRPLQLGNE-SLEGGVPLEHLVTC VPSITVVTAQNGFKVIKWINNKPPVPN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCIMPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRDWRVTDYGICDLMDLLTEI PDTTITITQQPTDTVISVPKR-ER-TMEELERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSHYGFTKLIELFEAIPDVLMVLECGEEKVLSLTEVERIKALAAQLVKLL RAQKNSSLPVSQLLTEYSKTFGYGLRLQDFDASSLPALLTKL-CHVVKVVDGADGREVQL INRKSLRSLTSQLLALLMS------------------------------------QEDEN ITKGL---------KVEELSQYYLSIHGVALNPCEYGFLSLSELLKSLPYLVE------- ---V-------------------------------------------------KFVRLTR LYQFARNVRALLHTYHYNQIFLTEFHGAYNKFTGCSLDPRFCGYTSVDELLSAIPQVIWI KGHGHKRIIVLKNDMK----------------GK-------------------------- -----------------G-----P--ENTESP---------------------------- -----------------------------------RDSP-------------------IS SATSGAQT---------------------------------------------------- ------------------------------------------------------------ ------AES------------------------ELLCL--SSPVDLLCGPVPSCLPSPQL HPDPVVVQ-QADLIYFEE------------------------------------------ --------------------------------RTP------------------------- ------------------------PL---------------------------------- ------------------PT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GG----PSDLYCFCGIKLKGSVLFAPFPSVVKCELDSPSLPPHPL >ENSONIP00000023760 -----------------------------------------------------ME----- ---------------G-LGKERSTCGARSFPWLG-H-----------TET-----EASTL LWKLKD---------CFSTD---------------ET---SSPHQTDK------------ ------------------S-NHMDNRKAVLDLKDVP--PP-PL----HHTS---SSQLSQ PF-SLSSL----PL---PP----------------------------------------- ---------------------------------------------------------QQE G----------------ASPKV--SICE-HCDYNNTD----------------------- -------------------GFGLLGGRGVVG------------------SGSNAAGVVSL YMAPGSLGA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PIST-------------------------------------------------------- ------------------------------------------------------------ -----------------------------SRSGPCSVASSVHQYKHK------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------FSQ--ASLFPSSAPMASSLP------------------------ ---------SVSSLP-----------------------ASLHGSCLTSSGFY-TCGVDCS ASA-R-RSQGS-ILGGHPSTSTI--TTTAT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------FS--------------N-PMHL NVER-TVCVKGAHYCQECLLK--------------------------------------- ---PMNGL-MAD----SDKVHPSVPIP--QTAPI--PIPICNGCGT---FSDGKMLMP-S TSLGKTGQKYG------SPEGSGPDSIPPVGVFWDIENCSVPSGRSAGAVVQRIRNRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFHVILVH-GSHTSSALLQHANSHVPFQEITADLPPR MLVK-------AQPSFNLLYVHNLPLNCDKNMRNAVKL---------RLRRLSDNCGGRV LG--VSQGTAVLRFGSPEAATRARKRMENEDVFGHRISLSFS------------------ ---------PRPRDD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VEEHQSNCLKE-------- --LASSTSLRVLNKC-------LSSSRKCYVH---------------------------- ------------------------KRALQLLMWCASFILTANA----------------- -----------------------------HLRTT--------------YELGSLEGKARM SFQHLEKG-CAASSSTQ--------------NN---------------GEAGALEQLTKP GLTVESIYRQ-------------------------------------------------- ---------------------------SRE------------------------------ --------------------------DSSPQSATESPVDQVDR----NSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLV------LSQGSW-SS-RRSASPCLSSRSSPLIAAP---- -RSPC-PE---------A--S-E-PFSEGAEIQVANLDYRMSRKDLQQTLNDTFSRYGRV KSVELSPHTDYQLKATIQMMSLQQAISAVSGLHRYKIGGKRIQVSLITGGSNKSLAMLSP EIISILQDAPASCLPLFKFTEIYEKKYSRKLVVGDLYRLPELVAVREQGGSRFVCLLSNS QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYSLQDFSEADFDPDSYKIP FVVTSLSTLASEVHSLLQSHQGTLPLLSFPDCYAAKFRPLQLGNE-SLEGGVPLEHLVTC VPSITVVTAQNGFKVIKWINNKPPAPN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCIMPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRDWRVTDYGICDLMDLLTEI PDTTITITQQPTDTVISVPKRAER-TMEELERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSHYGFTKLIELFEAIPDVLMVLECGEEKVLSLTEVERIKALAAQLVKLL RTQKNSSLPVSQLLTEYSKTFGYGLRLQDYDASSLPALLTKL-CHVVKVVDGADGREVQL INRKSLRSLTSQLVALLMS------------------------------------QEDEK VAKGL---------KVEELSQYYLSVHGVALNPCEYGFLSLGELLKSLPYLVE------- ---V--------------TASSH--------------------------G--EEFVRLTR LYQFARNVRALLHTYHYNQIFLTEFQGAYNKFTGCSLDPRVCGYTSIDELLSAIPQVIWI KGHGHKRIIVLKNDMK----------------AKPSC----------------------- -----SVPNS------PQ-----P--ENTESP---------------------------- -----------------------------------RDSP-------------------IS SATSGTQSPGN-------------------------------LP---GA----------- ------------------------------------------------------------ ---DAAAES------------------------ELLCL--SSPVDLLCGPVPSCLPSPQL HPDPVIVQ-QADLIHFEE------------------------------------------ --------------------------------RTP------------------------- ------------------------PL---------------------------------- ------------------PTVFISESDE-------HVVA--------------------- ------------------------------------------------------------ -------------------------------------------PADVTADLPAKRDGGTD DSA----------------------DP--------------------------------- --------------R--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ APPPPDT-------------------KTLLSM---------------------------- -----------------------------------------------DSPSRRASRSRIK LAANFSFTAG-------------------------------------------L >ENSACIP00000024019 M----------------------------------------------------ME----- ---------------G-LGKERSTCGARPFPWLG-H-----------PKT-----EASTL LWKLKD---------CFSTD---------------ET---SSPHQTDK------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EYKHKVSCGTGGDVFDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LFSLGCKPQLSS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPLSSHPYLPCCSGLLHTHPAV-------------------------- ------------------------------------------------------------ -------------PLSFSQ--ASLFPSSAPLASSLP------------------------ ---------TVSSLP-----------------------ATMHGSCLTSSGFY-TCGVDCS TSA-R-RSQGS-IFGGHP--STI--TTTAT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMHP NVER-TVCVKGAHYCQECLLK--------------------------------------- -----------DFVHGSDKVHPSVPIP--QTAPI--TIPICNGCGT---TSDGKMLMP-S TSFGKAGQKYG------SPESGGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRNRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFHVILVH-GNHTSSALLQHAHRHVPFQEITADLPPR MLVK---------PSFNHLYVYNLPLNCDKNMRNAVKL---------RLRRLSDNCGGRV LG--VSQGSAVLRFGSPEAAARARKRMENEDVFGHRISLSFS------------------ ---------PRPRDDASPEAELRSQPHHL--PQTLSQTSQTQDSVYD------QYPTGRY LQLNIFLPCLIQ------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELGSLEGKSRI SFQHFEKG-RTASSSPQ--------------NN---------------GEAGALEQLTKP GLTVESMYR--------------------------------------------------- ------------------------------------------------------------ ------------------------------KSASESPVDQVDR----SSG---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLV------LSQGSW-SS--RSASPCLSSRSSPLITAP---- -RSPC-PE---------A--SPE-PFSEGAEVQVANLDYRMSRKDLQQTLNDTFSRYGQV KAVELSPHTDYQLKATIQMMSLQQAISAVSGLHRYKIGGKRIQVSLITGGSNKSLALLST EIICILQDAPANCLPLFKFTEIYEKKYSRKLVVGDLYRLPELVAVREQGGSRFVCLLSNS QIRQSPLGSS--QSQEGSSSTSGSPVVFEELEYHEPVCRQHYAQQDFSEADFDPDSYKIP FVVMSLSTLASEVHSLLQSHEGTLPLLSFPDCYAAKFSPLQLGNE-SLEGGVPLEHLITC VPSITIVTAQNGFKVIKWVNNKPPAPN-SE------PWIHRCKSPVGNPQLIQFSREIID LLKSQPSCITPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRDWRVXDYGICDLMDLLTEI PDTTITITQQPTDTVISVPKK-ER-TMEEVERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSHYGFTKLMELFEAIPDVLIVLECGEEKVLTLTEVEHIKALAAQLVKLL RAQKNSSLPVSQLLTEYSKTFGYGLRLQDYDASSLPALLAKL-CHVVKVVDGADGREVQL INRKSLRSLTSQLLALLMS------------------------------------QEDEQ VTIGL---------KVEELSQYYLSVHGATLNPCEYGFLSLSELLKSLPYLVE------- ---V---RTR-------------------------------------------EWVKLTG LYQFARNVRALLHTYHYNQIFLTEFQGAYTKFTGCSLDPRSYGYTSTDELLSAIPQVIWI KGHGHKRIIVLKNDMK----------------AK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------LFKKCWS------------AFL----SDFMIYLP---GA----------- ------------------------------------------------------------ ---DAAAES------------------------ELLCL--SSPVDLLCGPVPSCLPSPQL HPDPVIVQ-QADLIHF-E------------------------------------------ --------------------------------RTP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PSTGSHFDLYIFGSTGDYGD-------------- -------------RR--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ EPPPPDT-------------------KTLLST---------------------------- -----------------------------------------------DSPSRRAXRSRIR LAANFSYTAG-------------------------------------------L >ENSBSLP00000007034 M----------------------------------------------------ME----- ---------------G-LGEERSTCSSRPFPWLS-P-----------PKT-----EASGL LWKFKD---------CFSTS---------------ET---PTPHRTDKQ----------- ------------------N-SYMESRKAVLELRDVP--PP-PP----HHT----TSQSSQ PF-SLATL----PL---LP---------------------------PCL----------- ------------PPQLTQDTH-QQQ---------L-----------P---------QQQE G----------------SRPKV--SICT-HCDYCSRD----------------------- -------------------GYGLLGGGDVVG------------------RRNSVAGVVSL YVAQGSPGA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PV---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------VSSNSINKS------------------ -----------------------------------------------------------G P----------------------------------------------C-------SVATS HNHHKLNLNSGNEATNPLLR-------------CQPHLPA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------AIATCQPVSSHSYLPCCLG-LHTCPAI-------------------------- ------------------------------------------------------------ -------------SLPCSQ--ANLFASSVPLASSPPVSSLSGN----------------- ----------------------------------------LHGTCLASSGCY-SYGV-CS PSAIR-RSQRG-TLGDHTTTTTV--TTTTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PLHL NVER-TVLVKGAHYCKECLLK--------------------------------------- ---PINDL-SSE----SDKMWPSAPIP--QTVSL--PVPICNGCGT---SSDGMQLMP-L TGLGNVGQKYG------SPENNGPENIPPVGVFWDIENCSVPSGRSAGAVVQRIRSHFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVVLVH-GSHTSPALLQHAHRHVAFQEITADLPPR TLVK-------SQPSYNFLYVHNLPVNCDKSLRNAVKL---------RLRRLSDNCGGKV LS--MSQGSAVLRFGSPEAAARARKRMENEDVFGRRISLSFS------------------ ---------PHPRDYASPEPVLQSHP--LPQNATLPQPYESQDS---------------- -----------VF----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------APP----------------- -----------------------------PSI---------------------------- --------SSFSFLP-------------------------LEK---PRSPRRPRRA---- -TR------PSHTSG-QV----------LERLYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGTPAKPLQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELAGLESKPRT DFHPLDEV-RAASSSPH--------------SN---------------GEMGTLEQVKKP SIAGESLYRR-------------------------------------------------- ---------------------------RRE------------------------------ --------------------------GSSPRRVSESPVEKREG----NSG---------- ----------------------------------------------------------EF QISTPSAFSKLTLHRSFSPLV------LSQGSW-SS--RSASPCLSSRSSPLLAVP---- -RSPC-PE---------G--SYE-QFIDGAEIQVANLDYRMSRKDLQQTLHDTFSRYGRV KAVELSPHTDYQLKAIIQMLSLQQAISAVSGLHRYKIGGKRIQVSLITGSSNKSLTMLST EIRSILQDAPANCLPLFKFTEIYEKKYSRKLSTGDLYRLPEVVAVREQGGSRLVCLLPSS LIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYAQQDFSEADFDPDSCKIP FTVMSLSTLTSDVHSLLHSHEGTLPLLSFPDCYAAKFRPLQLGNE-TLEGGVPLEHLITC VPSITIVTAQNGFKIIKWIHNKPPAPN-TE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCIMPISKFIPSYHHHFAKQCRVSDYGYSKLMELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVSINDFMQAYHWCFSRDWRVIDYGICDLMDLLTEI PDTTITITQQDTDTVISVPKR-ER-TVDEMERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLIELFEAIPDVLMVLECGEEKMLTLTEVERIKALAAQLVKLL RGQKNSSLPVSQLLTEYSKTFGYGLRLQDYDAGSLPALLTKL-CHVVKVVDGSEGREVQL INRKSLRSLTSQLLAILMS------------------------------------QDEDL VINGL---------KVEELSQYYSTVHGVQLNPCEYGFLSLSELLKSLPYLVE------- ---LYNRESD-ENGKAGSTASGQ--------------------------V--EGWVRLTR LYQFARNIRALLHTYHYNQIFLTEFQGAYNKFTGCSLEPRSYGYASTDELLSAIPQVVWI KGHGHKRIIVLKNDMK----------------ARASS----------------------- -----SVTNS------PQ-----P-GENAESP---------------------------- -----------------------------------RDSP-------------------IN --TSGAQS-----------------------------------P---SN----------- ------------------------------------------------------------ ---KVASES------------------------ELLCL--SSPVDLLCGPVPSCLPSPQL HPDPVLLQ-QTDLIHFEE------------------------------------------ --------------------------------KTS------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PT-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------DDDEP------------------------------- ----ASAAASGTDCACDPPKQSCSTDDLTGTKSQPATLT--------------------- --------------------------KTPLSV---------------------------- -----------------------------------------------DNPSRRASRSRIK LAANFSFTAG-------------------------------------------V >ENSMMOP00000009603 M----------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------IMRININLQD VVTDCEIMKKNVLVFVFQN-NDMDNRKAVLKLKDVP--PP-PP----HHTS---SSQ--- PF-PLAPL----TL---LP---------------------------PCLP---------- ------------SPQLTQDPC-QQQ---------P-----------P-------PPQQQE R----------------AIPKV--SMCT-QCEYCRTD----------------------- -------------------GYRLVGG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------RGYKHNLNSGSERDILDPLLNLTCNPL ------------------------------------------------------------ PL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------S-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPVSSHPYLACCSGLLHAYPPV-------------------------- ------------------------------------------------------------ -------------PLSCSQ--PSLCTSSAPLAPPLP------------------------ ---------CVSSLP-----------------------VAGCGSCLASSGYY-SCGVDCS ------------------------------------------------------------ ------------------------------------------------------------ -----------HF----------------------------------------------- --------------------------------------CS--------------N-PLHL NIER-TVCLKGVHYCQECMLK--------------------------------------- ---PTNGL-PSD----SDKVWPNVPVP--QTASV--PIPICNGCGH---SSDGMMLMQ-S TSLGKAAQKYG------SPENSGPENLPPVGVFWDIENCSVPSGRSAGAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTTP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GNHTSSALLQHAHRHVAFQEITADLPPR MLVK-------AQPSFNLLYAHNLPINCDKSLWNAVKL---------RLRRLSDNCGGKV LG--MSQGTAVLRFGSPEAASRARKRMENEDVCGHRISLSFS------------------ ---------PRPRDDASPELELQSRPHHLPQPQTLPQTYQNQDSV--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------RE------------------------------ --------------------------DSSPRSVTESPVEQKDM----NSV---------- ----------------------------------------------------------EF QVSTPSAFSKLNLHSSFSPLT------LSQGSW-SS--RSASPCLSSRSSPLLPAP---- -HSPC-HE---------G--PPE-PFSDGAEVHVANLDYRMSRKELQQTLHDTFSRYGRV KAVELSPHTDYQLKATIQMLHLRQAISAVSGLHRYKIGGKRIQVSLITGGNNKSLALLST EIISILHDAPANCLPLFKFTEIYEKKYSHKLVVADLYRLPEVVAVREQGGSRLVCLLPSS QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYSQHDFSEADFDPDSYKIP FVVMSLSKLSSEVHCLLQSHEGALPLLSFPDCYAEKFCPLQLGNE-TLEGSVPLEHLITC IPSITIVTAQNGFKVIKWIHNKPPSSN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPCCIVPMSKFIPSYHHHFAKQCRVSDYGYTKLLELLEAVPHVLQILGLGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRNWRVIDYGICELMDLLTEI PDTTITIAHQDSDTIISVPKR-ER-TVEEMERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFIKLIELFEAIPDILMVLECGEEKVLTLTEVERIKALAAQLVKLL RAQKNSSLPVNQLLTEYSKTFGYGFRLQDYDASSLPALLSKL-CHVVKVVDGSEGREVQL INRKSLRSLTSQLLDLLMS------------------------------------QEDEQ VTYGL---------RVEALSVRYFVIHGVQLNPCEYGFLSLSELLKSLPYLVE------- ---V-----------TGNTTNGR--------------------------G--EEWVRLTR LYQFARNVRALLHTYHYHQIFLTDFQGVYNKFTGCSLEPRSYGYVGTDELLSAIPQVVWI KGHGRKKIIVLKNDMK----------------A--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AAAES------------------------ELLSL--TSPVDLLCGPVPSCLPSPQL HPDPVLLQ-ETNLINFEE------------------------------------------ --------------------------------KSP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------TVNDEP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EVA----------------------------------ADGPSDPPEQPGSTEDTAIPK VPPPPNK-------------------KTPSSM---------------------------- -----------------------------------------------DSPSRRASRSRIK LAANFSFTAG-------------------------------------------I >ENSGACP00000025336 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------P-----------P------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------TI--TTTTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMHL NVER-TVCVKGAHYCQECLLK--------------------------------------- ---PMNGL-ASD----LEKAWPNAPIP--QSAPM--PIPICNGCGT---ASDGMMLMP-S ANLGKTGQKYG------SPENGGPENIPPVGVFWDIENCSVPSGRCAGAVVQRIRSNFFQ GHREAEFICVCDISKENKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GSHTSSALLQHAHRHMAFQDITADLPPR LLVK-------AQPSFNLLYVHNLPVNCDKSLRNAVKL---------RLRRLSDNCGGKV LG--VAQGTAVLRFGSAEAAARAHKRMENEDVFGRRISVSFS------------------ ---------PRPRDDASPEPE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PEPESRPHPLTLAQTGQNQDFIKALQPQE GVQWASRWCSSKAPSVFLFEMCRMK----------------------------------- -------------------------------------------------------GKPRM SFHPLEKG-RAASSSPQ--------------SN---------------GETGAVEPLSKP GLTGESMYRK-------------------------------------------------- ---------------------------RRD------------------------------ --------------------------GSHPRSVTESPIEQADR----SSG---------- ----------------------------------------------------------DF QISTPSAFSKLNLHRSFSPLI------LSPGSW-SSSKRSASPCLSSRSSPLPAAT---- -RSPC-PE---------G--PHE-PFSDGAEVQVANLDYRMSRKDLQQTLHETFSRYGRV KAVELNPHTDYQLKATIQMFSLQQAISAVSGLHRYKIGGKRIQVSLITGGSNKSLFLLSS EIISILQDAPASCLPLFKFSEIYEKKYSRKLVAGDLYRLPDVVAVREQGGSRLVCLLPSS QIRQSPLGSS--KSQEG-SSAGGSPVVFEELEYHEPVCREHYTQRDFSEADFDPDSYQIP FVVMSLSTIASEVHSLLQSHEGTLPLLSFPDCYAAKFGLLQLGNE-TLEGGVPLEHLITC VPSITIVTAQNGFKVIKWIHNKPPAPN-CE------PWIQRCKSPVGNPQLIQFSREIID LLKSQPSCLMPMSKFIPSYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKHVSIKDFMQAYHWCFSRDWRVIDYGTCDLMDLLTEI PDTTITITHQDMDTVISVPKR-ER-TADEIERTKQFGKEVVDLLRHQPHCRMAFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPNIVMVLECGEEKVLTLTEVERIKALAAQLVKLL RVQKNSSLPVSQLLTEYSKTFGYGLRLQDYDASSLPALLAKL-CHVVKVADGSEGREVQL INRKSLRSLTSQLLALLMS------------------------------------QEEQQ VTRGL---------RVEELSQHYLIVYGAPLNPCEYGFLSLSELLKSLPYLVE------- ---------------------------ARMRSKMT------------------EWVRLTR LYQFARNVRALLHTYHYNQIFLTEFQAAYSKFTGCGLEPRPFGYTSTDELLSAIPQVVWI KGHGHKRIIVLKNDMK----------------ARASP----------------------- -----SVPCS------PQ-----P-GQSMESP---------------------------- ------------------------------------------------------------ ----------------TSSLTSIATSGTHS-------------P---------------- --------------------------------------------------------GNVF LLADGAAES------------------------ELAFL--TSSGDLLCGPVPSCLPSPQL HPDPVLLQ-ETDLIHFEE------------------------------------------ --------------------------------KTPQT----------ESRLMLTSHLRVL SVSGEPEVAAVAESASDPDDSAARP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --PPPNA-------------------TCTASM---------------------------- -----------------------------------------------DSPSRRGTRSRIK LAANFSFTAG-------------------------------------------L >ENSKMAP00000029127 -----------------------------------------------------ME----- ---------------G-LGKEK----PRPAPWLI-H-----------PKA-----EASNL LWKLKD---------CFSPN---------------QT---TPSHLSNKD----------- ------------------N-THMDNRKAVLELKDVP--PP-PP----HHSP---PSQLSQ SF-SLAPL----SL---PP---------------------------PCLLP--------- ------------PPQFAQDSH-QKH---------P----------LP-------KQQQQE G----------------LSPKV--SICT-HCDYCSTD----------------------- -------------------GYGLLGGRGVVG------------------SSSSIAGI--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GTFHSAPSC-----PGA PISSN-R----------------------------------------------------- ------------------------------------------SR---------------- ----------------------FES---------CSVASSVHHYNHSLSCGNRTEATDS- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LLSFSFKPQLPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPFSLHPYFPCCSGLRHSCSAV-------------------------- ------------------------------------------------------------ -------------PLSRSQ--PGTFPSSAPPAS--------------------------- ---------SVSSLP-----------------------APLQGSCLASSGFN-TCGVDCN PSL-R-TSQRS-VPCDHPTTTTV--TTSTT------------------------------ ------------------------------------------------------------ ---------SVRR----------------------------------------------- --------------------------------------CS--------------N-SLHL NVER-TVCGKGAHLCQECLLK--------------------------------------- ---PKNDL-SSE----S-TVWPNVPIP--QTA----SVPICNGCGT---SPDNVTLMP-S TTHGKPGHKYG------SPENSGPENIPPIGVFWDIENCNVPSGRSAEAVVQRVRNRFFR GHREAEFICVCDINKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFSSELSDLRHRHGFQIILVH-GSHTSSALLQHAHLHVAFQEITADLPQR MLVK-------AQPSFNLLYVHNLPIICDKSLRNAVKL---------RLRRLSDNCGGKV LG--MSQGTAVLRFGSPEAAARARKRMENEDVFGHRISLSFS------------------ ---------PRPRNEAGPEVELQSQPCLL--PQTKPQTFQTQDS---------------- -----------VF----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------APP----------------- -----------------------------PSI---------------------------- --------PSFSFLP-------------------------LEN---PRSPRRPRRA---- -TR------PCPTPG-SM----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SSGPPGGAPAKPHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELGNMEAKSRM GLHPLERG-RAASSSPH--------------RN----------------ERGALEQLSQP GLRGESVY-R-------------------------------------------------- ---------------------------KRE------------------------------ --------------------------GYSPQSVTQLSVEQRDR----SSG---------- ----------------------------------------------------------EF HISTPSAFSKLNLHMSFSPLV------MSQGSW-SS--RSGSPCLSSRSSPLLATP---- -HGSC-NE---------G--PPE-PFSEGAELQVANLDYRMSRKELQQTLHDTFSRYGQV KAVELSPHTDYQLKATVQMLFLQQAISAVSGLHRYKIGGKRIQVSLITGGNNKSLSMLST EIICILQDAPANCLPLFKLTEIYEKKYSRKLAISDLYRLPDVLSVREQGGSRLACLLSSS QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYAQQDFSEADFDPDSYKIP FVAMSLSSLASEVHSLLESHEGTLPLLSFPDCYAAKFSPLQVGSE-TLEGAVSLEHLITC LPSISIVTAQNGFKVIKWLHNKPPAQN-SE------PWIQRCKSPVGNPQLIQFSREVID LLKSQPTCIMPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRDWRVTDYGVCDLMDLLTEI PDTTITITPQATDTVISVPKR-ER-TVEEIERTKQFGKEVVDLLRHQPHCRMPFSKFIPS YHHHFGRQCKLSYYGFTKLLELFEAIPDILMVLECGEEKVLTLTEVERVKALAAQLVRLL RSQKNFSLPVSQLLMEYSKTFGYGLRLQDYDASSLPALLAKL-CHVVKVVDGLEGREVQL INRKSLRLLTSQLLALLMS------------------------------------QENER VAKGM---------KVEELSRLYQTVHGAQLNPCEYGFLSLSELLKSLPYLVE------- ---LYCEESD-------------------------GN--DNSADTG--HG--YERVRLTR LYQFARNVRALLHTYHYNQIFLTEFQGAYSKFTGCSLEPRSYGYICTDELLSAIPQVVWI KGHGHKRIIVLKNDMK----------------AKTSS----------------------- -----SVPSS------PQ-----P-GEGAESP---------------------------- -----------------------------------RDSP-------------------VS SRTSGTQS-----------------------------------P---GG----------- ------------------------------------------------------------ ---EAIAES------------------------ELLFL--PSPLDLLCGPVPSCLPSPQL HPDPVVLQ-QMDLINFE------------------------------------------- --------------------------------RTP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------P------------------HLPAGSESEDAAADD ASDPPEQLGGSAASR--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------T---------------- ------------------------------------------------------------ -PPPSDT-------------------KNLLSV---------------------------- -----------------------------------------------NSPGRRAGRSKIK LAANFSFTAG-------------------------------------------L >ENSPREP00000000677 MDGARKE--------------------------SSTSGSRTAPWPFPPDVSSHL------ ------------------------------------------------------------ -WKHKN---------CFSSN---------------ET---TSLHQKKKD----------- ------------------N-IYMDNRKAVLDLKDVP--PP-PPPPLPHCPS---TSQLSQ PF-PLAPF----PL---PP---------------------------ACLPP--------- ------------SLQLTPDSH-QRH---------P-----------P-------SKPQQE G----------------ASPKV--SVCT-HCDYCSTD----------------------- -------------------GYGLLGGTGFDGGSNPQAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PISSS-RLEQRSVAPSTYRCNNLSHG---------------------------------- ----------------------------------------GGS----------------- ------------------------------------------------------EASDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LLTLDCKPQLPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SMATSQPPSFHPYFPCCSGLLPPRSAL-------------------------- ------------------------------------------------------------ -------------PLPHSQ--PSTFPSAPPLSS--------------------------- ------------SPP-----------------------APVQGSCLVSSGFY-TCGVDCS TST-RTRSLRA-TLGELSGSTTI--TTSTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMLR NVKH-TVCRNGGHFCQECLLK--------------------------------------- ---PKTAL-TSEP-----KVWPDVPAP--LTASI--PVPICNGCGT---SSDGMMLMP-P LNHGMIGYKYG------S-ENSGPENIPPVGVFWDIENCSVPSGRSAEAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFADTHAAP ATVILVSSDVNFASELSDLRHRHGFQVILIH-GNHTSSTLLQHAHRHVPFQEITADLPQR MPVK-------SQPSFSLLYVHNLPVICDKTLQNAVRL---------RLRRLSDNCGGKV QS--LSPGAAVLRFCSPEAAARARKRMENEDVFGYRISLSFT------------------ ---------PRPRDEVSPEAPLQARP--------------------------------RS LQTKVS-----VL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------APF----------------- -----------------------------PTI---------------------------- --------SSSSFLP-------------------------LEK---PRSPRRPRRA---- -TR------PFPTSA-LV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SSGPPGGAPAKPHQ-----EINMDAKSR VVLP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---HLGKG-RAASLSPQ------------------------------------------- ---------RKETGAPEEQAKTSLSG---------------------------------- ----------------------ESMH-KRE------------------------------ --------------------------CSSPRSVTGSPAAQRDQ----SSD---------- ----------------------------------------------------------EF KISTPSAFSKLNLNRSFSPLV------PSHGSW-SS--RSGSPCLSSRSSPLLTTA---- -RSSF-SE---------G--PSE-PLSEGAELQVANLDYRMSRKDLQQILHDTFSRYGQV KAVDLSPHTDYQLKATVQMTSLQQAISAVSGLHRHKIGSKRIQVSLVTGGNNKSLSLLST ELICILQDAPANCLPLFKLAEIYEKKYLHKLAIGELYKLSDVLSVREQGGSRLVCLLPSI QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYAKQDFSEADFDPESYKIP FVVMSPSSLSTEVHSLLQMHDGTLPLLSFPDCYAAAFSPLQVGNE-SLEDGVPLEHLITC VPSIAVVTAQNGFKVIKWVNNKPPGQN-SE------PWFQRCKSPVGNPQLIQFSREITD LLKSQPSCLMPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQIIGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVALKDFMQAYHWCFSRDWTVTDYGVCDLTDLLAEI PDTTITITNQTTDTVISVPKR-ER-TMEEMERTKQFAKEAVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLLELFEAIPDNLTVLECGEEKVLTLTEVERIKALAAQLVKLL RAQKNFSLSVSQLLVEYSKTFGYGLRLQDYDADTLPALLAKL-CHVVKVVDGSDGREVQL INRKSLRLLTTQLLALLMS------------------------------------QESDQ VTKGM---------KVEELSLQYLSVHGAQLNPCEYGFLSLSELLKSLPFLIE------- ---LYFEES-------------------------GGNVEDCSAGGG--HE--VEWVRLTR LYQFARNVRALLHTYHYNQIFLTEFQGAYSKFTGCSLEPRFYGYMSADDLLGAIPQVVWI KGHGHKRIIVLKNDMK----------------AKPSS----------------------- -----SVPSS------PQ-----P-GESMESP---------------------------- -----------------------------------RDSP-------------------IS STTSGTPS-----------------------------------P---GC----------- ------------------------------------------------------------ ---D--ADS------------------------ELLRL--ASPVDLLCGPVPSCLPSPQL HPDPVLLQ-QMDLIDFE------------------------------------------- --------------------------------RTP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PQ-------------------------------- ------------------------------------------------------------ --------------------------------------------------------P--- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------P--------------------------- ------------------------------------------------------------ ---------------------------------TELESVEEAAADGPSDPAERRGGSDAA PSF--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----PEG-------------------KNILSM---------------------------- -----------------------------------------------DSPGRRASRSRFK LAANFSFTAG-------------------------------------------L >ENSPFOP00000011619 MDGVRKE--------------------------SSTSSSRTVPWPFPPDVSSHL------ ------------------------------------------------------------ -WKHKN---------CLSSN---------------ET---TSLYQKKKD----------- ------------------N-IYMDNRKAVLDLKDVP--PP-PPPPLPHCPS---TSQLSQ PF-PLAPL----PL---PP---------------------------ACLPP--------- ------------TLQLTPDSH-QRH---------P-----------P-------SKPQQE G----------------ASPKV--SICT-HCDYCSTD----------------------- -------------------GYGLLGGTGFVGGSNPQAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PISSSCRLEQRSLAPSTYRCNNLSHG---------------------------------- ----------------------------------------GGS----------------- ------------------------------------------------------EASDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LLTLDCKPQLPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SMATSQPPSFHPYFPCCSGLLPPRLAL-------------------------- ------------------------------------------------------------ -------------PLPHSQ--PSTLPSASPLSS--------------------------- ------------SPP-----------------------APVQGSCLVSSGFY-TCGVDCS TST-RTRALRT-TLGELSGSTTI--TTSTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMLR NVKH-TVCRNGGHFCQECLLK--------------------------------------- ---PKTAL-TSEP-----KVWPDVPAP--LTASI--PVPICNGCGT---SSDGMM----- LNHGMIGYKYG------S-ENSGPENIPPVGVFWDIENCNVPSGRSAEAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFADTHAAP ATVILVSSDVNFASELSDLRHRHGFQVILIH-GNHTSSTLLQHAHRHVSFQEITADLPQR MPVK-------SQPSFSLLYVHNLPVICDKTLQNAVRL---------RLRRLSDNCGGKV QS--LSPGAAVLRFGSPEAAARARKRMENEDVFGYRISLSFT------------------ ---------PRPRDEVSPEAPLQARP--------------------------------RS LQTKVS-----VL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------APF----------------- -----------------------------PTIS--------------------------- -------SSSSSFLP-------------------------LEKPRSPRSPRRPRRA---- -TR------PFPTSA-LV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SSGPPGGAPAKPHQ-----EINMDAKSR VGLP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---QLGRG-RAASLSPQ------------------------------------------- ---------RRETGAPEEQAKTSLSG---------------------------------- ----------------------ESMH-KRE------------------------------ --------------------------CSSPRSVTGSPAAQRDQ----SSD---------- ----------------------------------------------------------EF KISTPSAFSKLNLNRSFSPLV------PSHGSW-SS--RSGSPCLSSRSSPLLATA---- -RSSF-SE---------G--PSE-PLSEGAELQVANLDYRMSRKDLQQILHDALSRYGQV KAVDLSPHTDYQLKATVQMTSLQQAISAVSGLHRHKIGSKRIQVSLVTGGNNKSLSLLST ELICILQDAPANCLPLFKLAEIYEKKYLHKLSIGELYKLSDVLSVREQGGSRLVCLLPSI QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYAKQDFSEADFDPESYKIP FVVMSLSSLSAEVHSLLQMHDGTLPLLSFPDCYAAAFSPLQVGNE-TLEDGVPLEHLITC VPSIAVVTAQNGFKVIKWVNNKPPGQN-SE------SWFQRCKSPVGNPQLVQFSREIID LLKSQPSCLMPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQIIGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVALKDFMQAYHWCFSRDWRVTDYGVCDLTDLLAEI PDTTITITNQTTDTVISVPKR-ER-TVEEMERTKQFAKEAVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDNLTVLECGEEKVLILTEVERIKALAAQLVKLL RAQKNFSLSVSQLLVEYSKTFGYGLRLQDYDAATLPALLAKL-CHVVKVVDGSDGREVQL INRKSLRLLTTQLLALLMS------------------------------------QESDQ VAKGM---------KVEELSRQYLSVHGAQLNPCEYGFLSLSELLKSLPFLIE------- ---LYVEES-------------------------GENVEDCS-GGG--RE--VEWVRLTR LYQFARSVRALLHTYHYNQIFLTEFQGAYSKFTGCSLESRFYGYMSVDDLLGAIPQVVWI KGHAHKRIIVLKNDMK----------------AKPSS----------------------- -----SVPSS------PQ-----P-GESMESP---------------------------- -----------------------------------RDSP-------------------IS STTSGTQS-----------------------------------P---GC----------- ------------------------------------------------------------ ---D--ADS------------------------ELLRL--ASPIDLLCGPVPSCLPSPQL HPDPVLLQ-QMDLIDFE------------------------------------------- --------------------------------RTP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PQ-------------------------------- ------------------------------------------------------------ --------------------------------------------------------P--- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------P--------------------------- ------------------------------------------------------------ ---------------------------------TELESVEEAAADGPSDPAERRGGSDAS PSL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----PEG-------------------KNILSM---------------------------- -----------------------------------------------DSPGRRASRSRFK LAANFSFTEG-------------------------------------------L >ENSPLAP00000004712 MD---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------NRKAVLDLKDVP--PP-PPPLLPHY----------- ------------------------------------------------------------ -------------------SH-QRH---------P-----------P-------SKPQQE G----------------ASPKV--SICT-HCDYCSTD----------------------- -------------------GYGLLGGTGFVGGSNPQAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PISSSCRLEQRSLAPSTYRCNNLSHG---------------------------------- ----------------------------------------GGS----------------- ------------------------------------------------------EASDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LLTLDCKPQLPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SMATSQPPSFHPYFPCCSGLLPPRLAL-------------------------- ------------------------------------------------------------ -------------PLPHSQ--PSTLPSASPLSS--------------------------- ------------SPP-----------------------APVQGSCLVSSGFY-TCGVDCS TST-RTRALRT-TLGELSGSTTI--TTSTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMLR NVKH-TVCRNGGHFCQECLLKVGSVH----------------CFNVFAALPKSSNCSFYF VRS--------------------------------------------------------- ----------G------S-ENSGPENIPPVGVFWDIENCNVPSGRSAEAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFADTHAAP ATVILVSSDVNFASELSDLRHRHGFQVILIH-GNHTSSTLLQHAHRHVSFQEITADLPQR MPVK-------SQPSFSLLYVHNLPVICDKTLQNAVRL---------RLRRLSDNCGGKV QS--LSPGAAVLRFGSPEAAARARKRMENEDVFGYRISLSFT------------------ ---------PRPRDEVSPEAPLQARP--------------------------------RS LQTKVS-----VLTG--------------------------------------------- ----------------------LSGE---------------------------------- ------------------------------------------------------------ --------------------------------------SI-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------E------------------------------ --------------------------CSSPRSVTGSPAAQRDQ----SSD---------- ----------------------------------------------------------EF KISTPSAFSKLNLNRSFSPLV------PSHGSW-SS--RSGSPCLSSRSSPLLATA---- -RSSF-SE---------G--PSE-PLSEGAELQVANLDYRMSRKDLQQILHDALSRYGQV KAVDLSPHTDYQLKATVQMTSLQQAISAVSGLHRRKIGSKRIQVSLVTGGNNKSLSLLST ELICILQDAPANCLPLFKLAEIYEKKYLHKLAIGELYKLSDVLSVREQGGSRLVCLLPSI QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYAKQDFSEADFDPESYKIP FVVMSLSSLSAEVHSLLQMHDGTLPLLSFPDCYAAAFSPLQVGNE-TLEDGVPLEHLITC VPSIAVVTAQNGFKVIKWVNNKPPGQN-SE------SWFQRCKSPVGNPQLIQFSREIID LLKSQPSCLMPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQIIGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVALKDFMQAYHWCFSRDWRVTDYGVCDLTDLLAEI PDTTITITNQTTDTVISVPKR-ER-TVEEMERTKQFAKEAVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDNLTVLECGEEKVLILTEVERIKALAAQLVKLL RAQKNFSLSVSQLLVEYSKTFGYGLRLQDYDAATLPALLAKL-CHVVKVVDGSDGREVQL INRKSLRLLTTQLLALLMS------------------------------------QECDQ VTKGM---------KVEELSRQYLSVHGAQLNPCEYGFLSLSELLKSLPFLI-------- -------------------------------------------------E--VEWVRLTR LYQFARSVRALLHTYHYNQIFLTEFQGAYSKFTGCSLEPRFYGYMSVDDLLGAIPQVVWI KGHAHKRIIVLKNDMK----------------AKPSS----------------------- -----SVPSS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------C----------- ------------------------------------------------------------ ---D--ADS------------------------ELLRL--ASPVDLLCGPVPSCLPSPQL HPDPVLLQ-QMDLIDFE------------------------------------------- --------------------------------RTP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PQ-------------------------------- ------------------------------------------------------------ --------------------------------------------------------P--- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PT-------------------------- ------------------------------------------------------------ ------GRT----------------------LLT---------ADGPSDPAERRGGSDAS PSL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----PEG-------------------KNILSM---------------------------- -----------------------------------------------DSPGRRASRSRFK LAANFSFTEG-------------------------------------------L >ENSXMAP00000028820 M----------------------------------------------------------- ------------------------------------------------------------ -----SPATYGNIKTCFSSN---------------ET---ASLHQKKKD----------- ------------------N-IYMDNREAVLDLKDVP--LP-PPPLLPHCPS---TSQLSQ PF-PLAPL----PL---PP---------------------------TCLLP--------- ------------SLQLTPDSH-QRH---------P-----------P-------SKPQQE G----------------ASPKV--SICT-HCDYCSTE----------------------- -------------------DYGLLGGTGFVGGSNPQAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PISS--RLEQCSVAPSTYRCNNLSHG---------------------------------- ----------------------------------------GGS----------------- ------------------------------------------------------QASDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LFTLDCKPQLPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SMATSQSPSFHPYFPCCSGLLPPCSAL-------------------------- ------------------------------------------------------------ -------------PLPHSQ--PSTFPSASPLSS--------------------------- ------------SPP-----------------------APVQGSCLVSSGFY-TCGVDCS TST-RTRSLRT-TLGDLSGSTTI--TTSTT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMLQ NVKH-AVCRNGGHFCQECLLK--------------------------------------- ---PKTAL-TSEP-----KVWPDVPAP--LTASI--PVPICNGCGT---SSDGLMHMP-P LNHGMIGYKYG------S-ENSGPENIPPVGVFWDIENCNVPSGRSAEAVVQQIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFADTHAAP ATVILVSSDVNFASELSDLRHRHGFQVILIH-GNHTSSTLLQHAHRHVPFQEITADLPQR MPVK-------SQPSFSLLYVHNLPVICDKTLQNAVRL---------RLRRLSDNCGGKV QS--LSPGAAVLRFGSPEAAARARKRMENEDVFGYRINLSFT------------------ ---------PRPRDEVSPEAPLQARP--------------------------------RS LQTKVS-----VL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------APF----------------- -----------------------------PSI---------------------------- --------SSSSFLP-------------------------VEK---PRSPRRPRRA---- -TR------PFPTSA-LV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SSGPPGGAPAKPHQ-----ETNVDAKSR VGLP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---HLGGG-RAASLSPQ------------------------------------------- ---------RKETGALEDQAKTGLSG---------------------------------- ----------------------ESKHKKRE------------------------------ --------------------------GSSPRSVTGSPAAQRDQ----SSD---------- ----------------------------------------------------------EF KISTPSAFSKLNLNRSFSPLV------PSHGSW-SS--RSGSPCLSSRSSPLLTTA---- -PNAF-SE---------G--PSE-PFSEGAELQVANLDYRMSRKDLQQILHDAFSRHGQV KAVNLSPHTDYQLKATVQMTFLQQAISAVSGLHRYKIGSKRIQVSLITGGNNKSLSLLST EIICVLQDAPANCLPLFKLAEIYEKKYLHKLAIGELYKLSDVLSVREQGGSRLVCLLPSI QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYAKQDFSEADFDPESYKIP FVMTSLSSLSTEVHSLLQLHDGTLPLLSFPDCYAAAFSPLQVGNE-NLEDGVPLEHLITC VPSITVVTAQNGFKVIKWVHNKPPGQN-SE------PWFQRCKSPVGNPQLIQFSREIID LLKSQPSCLMPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQIIGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVALKDFMQAYHWCFSRDWRVTDYGICDLMDLLAEI PDTTITITNQTTDTVISVPKR-ER-TVEEMERTKQFAKEVVDLLRHEPHSRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDILTILECGEEKVLTLTEVERIKALAAQLVKLL RAQKNFSLSVSQLLIEYSKTFGYGLRLQDYDTATLPALLAKL-CHVVKVVDRPDGREVQL INRKSLRLLTTQLLALLMS------------------------------------QENDH MTKGM---------KVEELSHHYLSVHGAQLNPCEYGFLSLSELLKSLPYLVE------- ---LYFEES-------------------------GGNVEDRSSGGG--HG--VEWVRLTR LYQFACNVRALLHTYHYNQIFLTEFQGAYSKFTGCSLEPRFYGYMSTDDLLSAIPQVVWI KGHGHKRIIVLKNDMK----------------AKPSS----------------------- -----SGPSS------PQ-----P-GESMESP---------------------------- -----------------------------------RDSP-------------------IS STTSGTQS-----------------------------------P---GC----------- ------------------------------------------------------------ ---D--ADS------------------------ELLRL--ASPVDLLCGPVPSCLPSPQL HPDPVLLQ-QMDLIDFE------------------------------------------- --------------------------------RTP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PQ-------------------------------- ------------------------------------------------------------ --------------------------------------------------------P--- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------P--------------------------- ------------------------------------------------------------ ---------------------------------TELESVEAAAADGPSDPAEQRGGSDAS PSL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----PEG-------------------KNILST---------------------------- -----------------------------------------------DSPGRRASRSRFK LAANFSFTAG-------------------------------------------L >ENSGAFP00000019718 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MDNRKAVLDLKDVP--LP-PPPPLPHCAS---TSQLSQ PF-PLVPL----PL---PP---------------------------AY------------ -------------------SH-QRH---------P-----------P-------SKPQEE G----------------ASPKV--SICT-HCDYCSTE----------------------- -------------------GYGLLGGTGFVGGSNPQAA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PISS--RLEQRSVAPSTYRCNNLSHG---------------------------------- ----------------------------------------GGS----------------- ------------------------------------------------------EASDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LFTLDCKPQLPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SMATSQPPSFHPYFPCCSGRLPPCSAL-------------------------- ------------------------------------------------------------ -------------PLPHSQ--PSTFPSASPLSS--------------------------- ------------SPP-----------------------APVQGPCLVSSGFY-TCGVDCS TS---TRSLRT-SLGDLSGSTTI--TTSAT------------------------------ ------------------------------------------------------------ ---------SAHF----------------------------------------------- --------------------------------------CS--------------N-PMLQ NVKH-AVCRNGGHFCQECLLKVGSLHYLKFWFSWNLMPRTALL--------KSSNSSFYF VLL--------------------------------------------------------- ----------G------S-ENSGPENIPPVGVFWDIENCSVPSGRSAEAVVQRIRSRFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFADTHAAP ATVILVSSDVNFASELSDLRHRHGFQVILIH-GSHTSSTLLQHAHRHVPFQEITADLPQR MPTGTMSLPPLSQPSFSLLYVHNLPVICDKTLQNAVRL---------RLRRLSDNCGGKV QS--LSPGAAVLRFGSPEAAARARKRMENEDVFGYRISLSFT------------------ ---------PRLRDEVSPEASLQARP--------------------------------RS LQTKV---------HPPLPHLC-------PSAREALQPQEGVQWASGRRSSQTSSGQQTL PRPPPSRCALSLSGLPCKSQEGF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------SPRSGTGSPAAQRDQ----SSD---------- ----------------------------------------------------------EF KISTPSAFSKLNLNRSFSPLV------PSHGSW-SS--RSGSPCLSSRSSPLLSTA---- -RSSF-SE---------G--PSE-PFSEGAELQVANLDYRMSRKDLQQILHDTFSRYGQV KAVDLSPHTDYQLKATVQMTLLQQAISAVSGLHRHKIGSKRIQVSLITGGNNKSLSLLST EVICILQDAPANCLPLFKLAEIYEKKYMHKLSIGELYKLSDVLSVREQGGSRLVCLLPSI QIRQSPLGSS--QSQEGSSSASGSPVVFEELEYHEPVCRQHYAKQDFSEADFDPESYKIP FVVISLSSLSTEVHSLLQMHDGTLPLLSFPDCYAAAYTPLQVGNE-TLEDGVPLEHLITC VPSIAVVTAQNGFKVIKWVHNKPPGQN-SE------PWFQRCKSPVGNPQLIQFSREIID LLKSQPSCLMPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQIIGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAFKDFMQAYHWCFSRDWRVTDYGVCDLMDLLAEI PDTTITITNQTTDTVISVPKR-ER-TVEEMERTKQFAKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDILTVLECGEEKVLTLTEVERMKALAAQLVKLL RAQKSCGLSVSQLLVEYSKTFGYGLRLQDYDAATLPALLAKL-CHVVKVVDGADGREVQL INRKSLRLLTTQLLALLMS------------------------------------QDGDR VTEGM---------KVEELSHHYLSVHGAQLNPCEYGFLSLSELLKSLPYLVEVGIRFLS EEP------------------------------------------------------LTR LYQFARNVRALLHTYHYNQIFLTEFQGAYSKFTGCSLQPRFYGYTSTDDLLGAIPQVVWI KGHGHKRIIVLKNDMKGKVRFRSPGVYLDVCR---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------GC----------- ------------------------------------------------------------ ---D--ADS------------------------ELLRL--ASPVDLLCGPVPSCLPSPQL HPDPVLLQ-QMDLIDFE------------------------------------------- --------------------------------RTP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PQ-------------------------------- ------------------------------------------------------------ --------------------------------------------------------PT-- ------------------------------------------------------------ -------------------------------------------------------TGQIS LGNSKLFDFLQDINTAHFPFVLFFCSESQRWSP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >ENSCVAP00000008936 MDGVRKERSADCSRTGPIHPKADVSSLQWKPKHS-------------------------- ------------------------------------------------------------ -----------------SSN---------------ET---TSFHQNYKG----------- ------------------N-ISMENHKAVPDLKDVP---P-PPPPLPPYPS---TSQLSQ PF-PLIPL----PL---PP---------------------------ACLPP--------- ------------SLQLTQDTH-QQH---------P-----------P-------SKQQQQ G----------------LSPKV--SICT-QCDYCSTD----------------------- -------------------SYGLLGG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------RGVVSSSICTPQTASGFLGTPGSSSSRLELCSLAPP IRCY-------------------------------NNLSCGGS----------------- ------------------------------------------------------EAFDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LLPLGCKPQLPS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPLSLQPCLPCCSGPLHPCSAL-------------------------- ------------------------------------------------------------ -------------PPSLSQ--SSTFPSSAPLSSV-------------------------- -----------TSPP-----------------------APGKDSCVVSSGFY-TCGVDCH TST-R------------------------TFQTSALGDQPSITAVTS------------- ---------------------------------------------------ST------- --------SSTHF----------------------------------------------- --------------------------------------TS--------------S-PMLQ NVKH-TVCRNAAHFCQECLLK--------------------------------------- ---PKPGP-ISES-----KLWPNVPPP--PASSI--PLPICNGCGT---LSDGMILVP-S TNHGKSGCKY---------ENSGPESMPPVGVFWDIENCSVPSGRSAEAVVQRIRSWFFQ GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFADTHTAP ATVILVSSDVNFASELSDLRHRHGFRVILIH-GSHTSSSLLQHAHRHVPFQQITADLPQR LFIK-------SQPSVSFLYVHNLPVISDKTLQNAVKL---------RLRRLSDNCGGKV QS--MSQGTAVLRFGSQEAAARARKRMDNEDVFGYRISLSFS------------------ ---------PRTRDDVGSEPQLQTEP--------------------------------RP FQTKVS-----VL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------APF----------------- -----------------------------PSI---------------------------- --------SSSSFLP-------------------------LEK---PRSPRRPRRA---- -TR------PFAASG-LV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SSGPPGGAPAKPLQ-----ETNMDGKSR VGLA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---HLDRG-RAASSSPQ------------------------------------------- ---------RRETRALEEQSKTDLTG---------------------------------- ----------------------EPIDDKRE------------------------------ --------------------------GSSPRRVTGSPVTQRVR----SS----------- ----------------------------------------------------------EF KISTPSAFSKLNLNRSFSPMV------PSQGSW-SS--RSGSPCLSSRSSPLLATA---- -RSSC-SE---------G--LSQ-PFSEGTELQVANLDYRMSRKDLQQILHDTFSRYGQV KAVDLSPHTDYQLKATVQMMSLQQAISAVSGLHRYKIGSKRIQVSLVTGANNKSLSLLST EIICILQDAPANCLPLFKLAEIYEKKYFRKLAIGDLYKLSDVLSVREQGGSRLVCLLPNI RIRQSPLGSS--QSQEASSSASGSPVVFEELEYHEPVCRQHYAKQDFSEADFDPESYKIP FVVMSLSSLASDVHSLLQVHDGTLPLLSFPDCYAAKFSPLQVGNE-MLEGAVPLEHLITC VPSITIVTAQNGFKVIKWIHNKPPAQN-SE------PWIQRCKSPVGNPQLIQFSREIID LLKSRPSCLIPISKFIPSYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQIIGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIRDFMQAYHWCFSRDWRVTDYGICDLMDLLAEI PDTTITITHQTTDTVISVPKR-ER-TAEEVERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLMELFEAIPDILMVLECGEEKVLTLTEVERIKALAAQLVKLL RAQKDFSLSVSQFLPEYSKTFGYGLRLQDYDVASVPALLTKL-CHVVKMVDGSEGRVVQL INRKSLRLLTSQLLALLMS------------------------------------QETHQ VSKGM---------KVEELSMHYMSIHGTQLNPCEYGFLSLSELLKSLPYLVE------- ---LYFEEN-------------------------G---EDCSSAGG--HG--VEWVRLTR LYQFARNIRALLHTYHYNQLFLTEFQGAYSKFTGCNLDPRFYGYSTTDELLGAIPQVVWI KGHGHKRIIVLKNDMK----------------AKPSS----------------------- -----SVPNS------PQ-----P-VD-MESP---------------------------- -----------------------------------RDSP-------------------IS S-TSGTQS-----------------------------------P---GC----------- ------------------------------------------------------------ ---D--AES------------------------ELLRL--TSPVDLLCGPVPSCLPSPQL HPDPVLLQ-QMDLINFE------------------------------------------- --------------------------------KTP------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PQ-------------------------------- ------------------------------------------------------------ --------------------------------------------------------P--- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------S--------------------------- ------------------------------------------------------------ ---------------------------------AELESVEEAAADGTCGPLDQSGVEDDS PAL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----PDE-------------------KNTLSM---------------------------- -----------------------------------------------DSPGRRASRSRFK LAANFSFTAG-------------------------------------------L >ENSGMOP00000005955 L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PP-------------------- ------------------------------------------------------TSTAQY G---------------------------------------------P------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------QS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----R---------------------------------HP-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ NVEC-MVCLKGSHYCQECLLK--------------------------------------- ---PVNGC-LPE----SDELWPGPP-------PVLAPLPMCNGCGT---AADGRLRPP-H HSLGKAGHQFG------SPDVGGPENTPPVGVFWDIENCCVPSGRSAAAVVQRLRGRFFQ GHREAEFICVCDISKECKTVIQDLNNCQVTVAHINATAKNAADDKLRQSLRRFAETHAAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GTHTSPALLQHAHRQVPFLEITADLPLR VPLK-------AQPSFSNLYVHNLPVACDKSLRGAVKL---------RLRRLSDNCGGKV LS--VSRGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEALQSQEGLRAARWSRGPIPSXXXXXXX XXXATPNTVFQLLENACSPTTTASSSSPEAADPALGRLP--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------KP GLMGESMFRX-------------------------------------------------- ---------------------------XGD------------------------------ --------------------------SSSPRRTVESPSRRGDR----GSP---------- ----------------------------------------------------------EF LVSTPSAFSKLNLHRSFSPLG------ASQGSW-SS---SASPSLSGRSSPLLPGP---- -RSPV-PD---------A--PAE-CLRDSPEVQVSNLDYRMSRKELQQS--DTFSRYGKV TCVELSPHTDYQLKAAVQMVYMQQAILAVSALQRYKIGGKRIHVCLATGGSSKPLFLFCS EIVGILHDAPANCLPLSKFTELYEKRFSRRLAVGDLYRLPEVVAVRDQGGARLVCLVAGG QARQSPLGSS--QSQEASSSACSSPVVFEELEYHEPVCQQHSTLHNFSEADFDPDSYQIP FVAMSLSAMAPQVHGLLQSHDGTLPLLSFPECYAAEFGPLQLGDE-TQEGAVSLEHLITC LPSITVVTAQNGFKVIKWIHNKPPAPN-SE------PWVQRSKSPVGNPQLIQFSREVID LLKSQPACLLPIHKFIPSYHHHFAKQCRVSDYGYPKLLELLEAVPHVLQILGMGAKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIKDFMQAYHWCFSRDWRVMDYGVCELMDLLNEM PETTVTLTRQDTHLVISVPKR-ER-TPEEMERTKQFGKEVVDLLRHQPHCRMAFSKFIPT YHHHFGRQCKLTCYGFTKLLDLFDAIPEVLTVLECGEEKGLSLTEVERVKALAAQLVKLL RSQRNCSLPVSLLLAEYGRTFGYGLRLQDYDAASLPSLLAKL-CHVVKVVDGAEGREVQL INRKSLRLLTCQLLMLLMS------------------------------------EEQPE --AGV---------SVEELSQRYLAAHALTLNPCEYGFLSLSELLKSLPYLVE------- ---V-------------------------------------------------DWVRLTR LYQFARGVRGLLHTYHYNQIFLTEFPSAYCKFTGRALLPRFYGYSSVDDLLGAVPQVVWV KGHGQKRIIVLKNDMK-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXG----- ------VES------------------------ELLYL--SSPLDLLCGPAPSCLPSPQL HPRPAGLHPHADLIHFE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------R--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >ENSHCOP00000026212 -----------------------------------------------------ME----- ---------------G-LGKERSVCSPKTSPWIG-H-----------PKK-----EASTL LWKVKD---------CFTTD---------------DT----------------------- ------------L-----G-NDMDSKKTVLELKDVP--PP-PM----HHAS---YSKPSP LF-PLPPL----PL---AP---------------------------SRLL---------- ------------PPQLTQDRH-QQQ---------P-----------P-------LQQQQE G----------------PSPKV--SACA-YCDYCITE----------------------- -------------------GYGLLDGGGVAG----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------CSIAS--------VSCGPKDDACDP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LLSCGCTPRKLS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVTTSQPISAQPHIHCCQGLLNTHP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------VEALPVKPASFPPHPLLASSLPPISASHAPLHGSCLASSDHY-ICGMDCS PMV-R-RTQTSAALCDHPASTPI--NTTST------------------------------ ------------------------------------------------------------ ---------SALL----------------------------------------------- --------------------------------------YS--------------N-PMHL NVEQ-TVSMKGVHYCQDCLFK--------------------------------------- ---PMNGF-VSK----SEKVWPNIPVS--QTAPI--SIPVCNGCGT---SSDNAAL---- -SQGKTGQKYG------SPENGGTENNPPVGVFWDIENCSVPSGRSAGEVVQRIRSRFFQ GHREAEFMCVCDISKENKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GNHTSQALLQHAHVHVSFQEITADLPPR MPLK-------TQPSYNLLYVHNLPVNCDKSLWNAVKL---------RLRRLSDNCGGKV LG--LSHGTAVLRFGSPEAASRARKRMENEDVFGHRISLSVS------------------ ---------P-------------------------------------------------- ---------------------CQDTMSITPVA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------TSSSFLP-------------------------LEK---PRSPRRSRRA---- -TR------PCYTPR-PL----------PERPYSPKRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSG------------------------- -------------ACSPFTSVDLSSA--------DSKPKP-------------------- ------------------------------------------------------------ ------------------------------------------------------------ GFLHLDKG-RPASSTPH--------------SN---------------GNIESPEQLSKP GFPGETLHKK-------------------------------------------------- ---------------------------RR------------------------------- ------------------------------------------------SV---------- ----------------------------------------------------------EF QISTPSAFSKLNLHRSFSPLV------LSQGSW-SS--RTASPCLSSRSSPMLAAP---- -RSPC-PE---------Y--PTE-PFSDGAEIQVANLDYRMSRKELQQTLRDTFFRYGRV KGVELSPHTDYQLKATIQMLSLQQAISAVSGLHRYKIGGKRIQVSLITGGHSKSLVMLSS EISSILQEAPANCLPLFKFTEIYEKKYHRKILMSDLYRLPDVVAIREQGGTRLVCLLPSS QIRQSPLGSS--QSQGSSSTPSGSPVVFEELEYHDPVCRQHYTQHSFSEADFDPDSYTIP FVVMSLRTLASEVHELLQSHEGTLPLLSFPDCYEAKFSRLELSNE-TLECGVPLEHLIAC VPSITIVTTQNGYKVIKWIHNKPPAPN-SE------PWLHRCKSPVGNPQLIQFSREIID LLKSQPSCIMPISKFIPSYHHHFAKQCRVSDYGYSKLFELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAVKDFMQAYHWCFSRDWNVADYGACDLIDLLSEI PDTTITTTHHDNDTVISVPKR-ER-TGDEIERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFNKLMELFEAIPEVLMVLECSEEKALTLTEVERIKALAAQLVKLL RAQKNCSLPVSQLLTEYSKTFGYGLRLQDYDTSSLPVLLSSITCHFCLVVDGTDGREVQL INRKSLRLLTSQLLALLMS------------------------------------QE-KH VDKGL---------RVDELRQHYQMVYKAPLNPCEYGFLSLSELLKSLPYLVE------- ---V--------------------------------------------RE--AEWVRLTR LYQFARNVRALLHTYHYNQIFLSEFQGAYRKFTGCGLESRSYGYISTDELLNAIPQVVWI KGHGHKRIIVLKNDMK----------------ERVSA----------------------- -----SVTSS------PQ-----S-EGNVESP---------------------------- -----------------------------------RDS---------------------- ------------------------TAMT---------------P---------------- ------------------------------------------------------------ -------ES------------------------ELLCL--TSSVDLLCGPVPSCLPSPQL HPDPVLMQ-QASLIRFEE------------------------------------------ --------------------------------KTP------------------------- ------------------------PLSHTSVVTREQKHIWMSISHFFFFTFHQVPSQSVL MSSESKEFHTGSAAQDGEPAA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PT-------------------------------- ----------------ETE----------------------------------------- --------------------------------------------------------P--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PLSM---------------------------- -----------------------------------------------DSPGRRGPRNRIK LAANFSFNSG-------------------------------------------C >ENSGWIP00000017270 M----------------------------------------------------ME----- ---------------G-QGKERSM---KPFQWPS-Q-----------PQP-----EAPSL LWKLKD---------CFSTN---------------ETKTTTSPHRTSPQ----------- ------------------S-DCMENRKAVLELKDVP--PP-PC----HTPS-------SQ SF-SLPRL----SL---PS---------------------------PCLLPP-------- ----------PPPHQLTQDSHRLQQ---------P-----------P-------SLQKQE V----------------DGPTV--SMCT-HC----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SPGGCRLNSSVPLYMIQASRGV---------------------------------- PVSVA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------STVYQSKPNVSYSSSGGEVLD-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SYKPQVSS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------SVTTSQPCSSDPYLPHYSGLQHTYPLVALQQSL-------------------- ------------------------------------------------------------ ------------HP------------------SSLP------------------------ ---------SASSFP-----------------------VSLHDSCLGSSGLY-TCGGDCS PSA-R-RSQGN-ALSDHTANTTV--TS--------------------------------- ------------------------------------------------------------ ---------TAHH----------------------------------------------- --------------------------------------FA--------------N-PMHV HAQC-TVSVKGAHNYRECCLK--------------------------------------- ---PLNGR-ISE----SDQGWPKVPLP--PTASI--PIPLCNGCGT---SSEGFVCMS-S TSVSKTGPKYG------SHESSGPENIPPVGVFWDIENCSVPSGRSAAAVVQRIRSRFFQ GHREAEFICVCDISKENKAVIQELNNCQVTVAHINATAKNAADDKLRQCLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GNYTSSALLQHAHTHVTFQEVTANLPIR MTPK-------VQPSFNLLYVYNLPFIIDKRQRNAVKV---------RLRRLSDNCGGRV LS--LSQGMAVLSFSSPEAAARASKRMENEDVFGHRISLSFF------------------ ---------PRPKPEFAP------RPHHL------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------PP----------------- -----------------------------PRVYHTQEPVQTPPQ---------------- ------FVPSFSYLP-------------------------LVN---LRSPRRPRRR---- -AR--------------LSV------YTPERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------CSGPPGGAPAKPRQ-----E-------- ------------------------------------------------------------ ------------------------------------------AGTSEDRVRLVLSHLEKG NNASSVHQSNGETGMQEPPPKSGLVGKPIH------------------------------ ------------------------------------------------------------ ---------R-------------------------------------------------- ---------------------------NRD------------------------------ --------------------------GSSPRKISESSVERGER----KAA---------- ----------------------------------------------------------DF QMSTPSAFNKLNLQRSFSPLV------LSQSSW-SS--RSASPCLSSRSSPLLATP---- -RSP---K---------D--SLQ-PFSGGAEIQVSNLDYRMSRKDLQRILHDTFSRHGQV KSLELSPHTDYQLKATVQMSSLQQAISAVSGLHRYKIGCKRIHVSLITGGCNKSLALFST EIICILQDAPANCLPLFKFTEIYEKKYSRKLMVNDLYRLPELVAVREQGGSRLVCLLSTS QIRQSPLGSS--LSQDCSSSASGSPVVFQELEYHEPVCRDHYAQQDFSEADFDPDSYKIP FVKTSLSTLASEVHSLLQSHEGTLPLLSFPDCYAAQFCPMQLVSE-SLDGGIPLEHLITC VPSITIVTAQNGFKVIKWIHNKPPAQN-SE------PWVYHCKSPVGNPQLIQFSREIID LLRSQPSCLMPISKFIPSYHHHFAKQCRVSDYGFSKLLDLLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAIRDFMQAYHWCFSRDWRVTDYGVCDLKDLLTEI PDTTITITDQASDMVISVPKR-ER-TVEEMERTKQFGKEVVDLLRHQPHCRMLFSKFIPT YHHHFGRQCKLSYYGFTKLMDLFEAIPDILMVLECGEEKLLTLTEVEQIKALAAQLVKLL RAQKSSSLPVSQLLPEYSKTFGYGLRLQDYDANSLLALLHKL-CHVVKVVDGSEGREVQL INRKSLRLLTSQLLSLLMS------------------------------------QEEDQ VSEGL---------QVDELSHRYKCVHGSLLNPCEYGFLSLSELLKSLPYLVE------- ---LYLKECD-VNGETG-------------TS---------TSSSG--HG--MEWVRLTR LYQFARHVRALLHTYHYNQIFMTEFQGAYGKFVGRSLEPRFYGHTSTDELLNAIPQVVWI KGHGQKRIIVLKNDMK----------------AKPSC----------------------- -----SLPNS------PR-----PGGEFTDSP---------------------------- -----------------------------------RDSP-------------------IS TSTSEAQS-----------------------------------S---GG----------- ------------------------------------------------------------ ---DIASDS------------------------ELLYL--NTHEDLLCGPVPSCLPSPQL HPDPVVPQ-QNDLIHFEEKS--------------------------------------LP RSTSSESDEPQTSEDNVSDHHEEQSSSEFSILKSP------------------------- ------------------------PTS--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TV---------------------------- -----------------------------------------------NSPNRRTSRSRIR LAANFSFTAA-------------------------------------------P >ENSOMEP00000008482 M----------------------------------------------------ME----- ---------------G-LGKEKS------------EGRSRAPPCPDTPRA-----DASTR QWELKG---------CFGSN---------------ET---TPLHQTNKI----------- ------------------N-HYMDTRKPLLELKDVP--PP-PQ----H----PPPLHLSK PL-PLPHL----PLPPPPP---------------------------PCFLA--------- ------------PPHLSQDCQ-QQR---------P-----------L------------E G----------------ASPKV--S----HCVYCSTD----------------------- -------------------GRGLLGG-------------------SAGNSSSTITGVVSL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------CRALCSMGD PICSS-----------------------SGSI---------------------------- ------------------------------------------------------------ ------------------------------RSGTCPVASSVR------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ P----------------------------------------------CQYPLSCNS---- ---------------------GGQVPESVLRLGCKPQLHS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------PVAISQPLSSHHCLPCCSGLLQTCSAV-------------------------- ------------------------------------------------------------ -------------PSPCSQ--PSSFP---------P------------------------ ---------SVPSLP-----------------------VSVHDSCLVSSGFY-TYDVSCD SSA-R-RSQRS-AHGDQTTGTAV--TTTTS------------------------------ ------------------------------------------------------------ ---------TAQF----------------------------------------------- --------------------------------------YS--------------N-PIHL NVER-TACVKGAHCCQDYLMK--------------------------------------- ---PVNGE-TSE----TNEVWPKLCVP--QTASH--PIPVCNGCGT---SSDAMALLS-N ASCG-TSFKYG------SPESGGSENIPPVGVFWDIENCNVPSGRSAGAVVQRIRSRFFK GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFRVVLVH-GSHTSSALLQHAHHHVAFQEITADLPLR PLDL-------TEPSFNLLYVHNLPVDCDKSLRNAVKF---------RLRRLSDNCGGKV LG--MSQGIAVLRFGSPEAAARACKRMENEDVFGHRITLSFS------------------ ---------PGSTEGAGPEAEPQTQPHHL--SQT--QTKQIQVS---------------- ------------------------------------------------------------ ---------------------GF------------------------------------- ------------------------------------------------------------ ----------------------------------------AHL----------------- -----------------------------PPA---------------------------- --------PAFSFLP-------------------------LEK---PRSPRRPRRA---- -TR------PCPTLG-PV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SSGPPGGSAAKLHQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DLTNVEAKPRM G---------------QQQVEKVPMLNSSHQSN---------------GE--TLEHLSKP GFSKESIYRRRE------------------------------------------------ --------------------------------ISHPHNGTGPPADKGDRN---------- ------------------------------------------------------------ -----------------------------------------------------------I QISTPLAFSKLNLHKSFSPVV------VSQGSW-SS--RSTSPCLSSRSSPLLAAT---- -HTP---D---------G--RAE-PFSEGAEVQVANLDYRMSRKDLHQTLRDTFSRFGQV NSVELSPHTDYQLKAAVQMASLQQAISAISGLHRYKIGSKRIQVSLVTGGNNKSL---ST EIISILQDSPANCLPVFKFLEIYEKKYSRKIAVSDLYKLPDLVSVREQGGSRLVCLLPHS QIRQSPLGSS--PSQEGSSSVNGSPVVFEELEYHKPVCEQHYAKRNFSEADFDPDTYKIP FVVMSLSTLASELNHLLESHGGTLPLLSFPDCYAAEFSPLVIGSE-TMKGAVPLEHLITC VPTITIVIAQNGFKVIKWLHSKPPAQI-SE------PWIQRCKSPVGNPQLIQFSREIID LLKGQPSCIMPISKFIPAYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAVKDFLQAYHWCFSRDWRVTDYGTCDLMDLLTEI PDTTITISHQSSDTVISVPKR-ER-TAEEMERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLVDLFEAIPDILKVLECGEEKVLALTEVERIKALAAQLVKVL RAQKNYSLPVSQLLTEYSKTFGYSLRLQDFDAPSLSTLLAKL-SHVVKVVDGAEGREVQL INRKSLRTLTYQLLALLMS------------------------------------QETDQ VPKGM---------KVEELSQRYQAVHGALLNPCEYGFLSLSELLKSLPNLMQ------- ---LYNEENE-ENFKA---------------------------------G--DEYVRLTR LFQFARNVRALLHTYHYNQIFLTEFQGAYSKFMGSSLEPRSYECVSIDDLLNAIPQVVWI KGHGHKRIIVLKNDMK----------------AKASS----------------------- -----SVPSS------PQ-----P----AESP---------------------------- -----------------------------------RDSP-------------------VS TATSGTHS-----------------------------------P---GA----------- -----------DG----------------------------------------------- ---DGAAES------------------------ELVCL--TPPVDLLCGPVPSCLPSPQL HPNPIAPH-HADLIHFEGRSASGQPA---------DGGPNPAEAPSLSREEDFPAARPL- ----------------------------------P------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------HQ-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SL---------------------------- -----------------------------------------------GSPSRRASRSRIR LAANFSLTSRSSHTSPAN----------------------------------PV >ENSORLP00020035036 M----------------------------------------------------ME----- ---------------GGLGKEK----------------SRATRCPDSPTA-----DASTP QWKLKD---------CFGSN---------------ET---ISPHQIHRN----------- ------------------N-HYMDTRKPLLELKDVP--PP-PQ----H----PPSPHLSK PL-PLRPL----PLPPPPP---------------------------PCFLA--------- ------------PPHLSQDCQ-QQQQL-------P-----------P------------E G----------------ASPKV--S----HCVYCSTA----------------------- -------------------GRGLLGGGGG--------------DADAGGSSSSIAGVVSL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------CRALCSMGD PICSS-----------------------SSSI---------------------------- ------------------------------------------------------------ ------------------------------RSGTCSVVSSVH------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ P----------------------------------------------CQQTLSCNT---- ---------------------RGQVPESVLRLGCKPQLHS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------PVAIAQPLSSHNCLPCCSGLLHTCSAA-------------------------- ------------------------------------------------------------ -------------PSPCSQ--ASSFP---------P------------------------ ---------SVSSLP-----------------------ASVHDSCLVSSGFY-TCDVGCN SSA-R-RSQRS-AHGDQTTATAV--TTTTS------------------------------ ------------------------------------------------------------ ---------TARF----------------------------------------------- --------------------------------------FS--------------N-PIHL NVER-TACVKGAHCCLDYL-K--------------------------------------- ---HVNGV-TSD----TDEVWPKVCVP--QTASL--PVPVCNGCGT---SSDAMALWP-N TSCG-TSYKYG------SPESGGCENIPPVGVFWDIENCNVPSGRSAGAVVQRIRSHFFK GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GSHTSSALLQHAHLHVAFQEITADLPQR PLDL-------TEPSFNLLYVHNLPVNCDKSLRNAVKF---------RLRRLSDNCGGKV LG--VSQGIAVLRFGSPEAAARACKRMENEDVFGRRITLSFS------------------ ---------PRSREGAHPEAEPQTQPHHL--SQTKPQTNQIQVS---------------- ------------------------------------------------------------ ---------------------GV------------------------------------- ------------------------------------------------------------ ----------------------------------------AHL----------------- -----------------------------PST---------------------------- --------PSCSFLP-------------------------LEK---PRSPRRPRRA---- -TR------PCPTLG-PE----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SSGPPGGAAAKLNQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DLTNVEAKPRM G----------------QQVEKVHMVNSSHQSN---------------GEMGALEHLSKP GFTKESGCRRRE------------------------------------------------ --------------------------------VSLPPNRTAPLVNKGDKS---------- ------------------------------------------------------------ -----------------------------------------------------------F QISTPLAFTRLNLHRSFSPVG------TSQASW-SS--RSASPSLSSRSSPLLAAP---- -RSP---N---------G--HAE-PFSEGAEVQVANLDYRMSRKDLQQTLRDTFSRFGQV HSVELSPHTDYQLKAAVQMSSLQQAISAVSGLHRFKIGSKRVQVSLVTGGSNKSL---SL EIISILQDSPANCLPVFKFLEIYEKKYSRKIAVSDLYKLPDLVSVREQGGSRLVCLLPHS QIRQSPLGSS--PSQEGSSSLNGSPVVFEELEYHNPVCEQHYSKQNFSEADFDPESYKIP FVVMSLNTLASELNHLLESHGGTLPLLSFPDCYAAEFSPLILGSE-MTEGAVPLEHLITC VPTVTIVIAQNGFKVIKWLHSRPPAQI-SE------PWIQRCKSPVGNPQLIQFSREIID LLKGQPSCIMPISKFIPAYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKRVAVKDFMQAYHWCFSRDWRVTDYGTCDLMDLLAEI PDTTITISHQSSDTVISVPKR-ER-TTEEVERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLVELFEAIPDILQLLECGEEKVLALTEVERIKALAAQLVKVL RAQKNYSLPVSQLLPEYSRTFGYSLRLQDFDTPSLSTLLAKL-SHVVKVADGAEGREVQL INRKSLRTLTYQLLALLMS------------------------------------QEADQ LPKGM---------KVEELSQRYQAVHGSPLNPCEYGFLSLSELLKSLPNLMQ------- ---LYHEDNE-ENVKA---------------------------------G--DEYVRLTR LFQFARNVRALLHTYHYNQIFLTEFQGAYSKFMGSSLEPRSYECVSIDDLLNAIPQVVWI KGHGHKRIIVLKNDMK----------------AKPSS----------------------- -----SVPSS------PH-----P----AGSP---------------------------- -----------------------------------RDSP-------------------VS GATSGSQS-----------------------------------P---GV----------- ------------------------------------------------------------ ---DDAAES------------------------ELLCL--ASPLDLLCGPVPSCLPSPQL HPNPIAPH-QVDLIHFEGHSASGPAAESCECQAATDGGSNPAEAP--GREEDFPASRAL- ----------------------------------P------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PQ-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SM---------------------------- -----------------------------------------------DSPSRRASRSRIR LAANFSFTSRSSHTSPAD----------------------------------PV >ENSORLP00000017059 M----------------------------------------------------ME----- ---------------GGLGKEK----------------SRATRCPDSPTA-----DASTP QWK--D---------CFGSN---------------ET---IPPHQIHRN----------- ------------------N-HYMDTRKPLLELKDVP--PP-PQ----H----PPSPHLSK PL-PLRPL----PLPPPPP---------------------------PCFLA--------- ------------PPHLSQDCQ-QQQQL-------P-----------P------------E G----------------ASPKV--S----HCVYCSTA----------------------- -------------------GRGLLGGGG-----------------DAGGSSSSIAGVVSL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------CRALCSMGD PICSS-----------------------SGSI---------------------------- ------------------------------------------------------------ ------------------------------RSGTCSVVSSVH------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ P----------------------------------------------CQQTLSCNT---- ---------------------RGQVPESVLRLGCTPQLHS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------PVAIAQPLSSHNCLPCCSGLLHTCSAA-------------------------- ------------------------------------------------------------ -------------PSPCSQ--ASSFP---------P------------------------ ---------SVSSLP-----------------------ASVHDSCLVSSGFY-TCDVGCN SSA-R-RSQRS-AHGDQTTATAV--TTTTS------------------------------ ------------------------------------------------------------ ---------TARF----------------------------------------------- --------------------------------------FS--------------N-PIHL NVER-TACVKGAHCCLDYL-K--------------------------------------- ---PVNGV-TSD----TDEVWPKVCVP--QTASL--PVPVCNGCGT---SSDAMALWP-N TSCG-TSYKYG------SPESGGCENIPPVGVFWDIENCNVPSGRSAGAVVQRIRSHFFK GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GSHTSSALLQHAHLHVAFQEITADLPQR PLDL-------TEPSFNLLYVHNLPVNCDKSLRNAVKF---------RLRRLSDNCGGKV LG--VSQGIAVLRFGSPEAAARACKRMENEDVFGRRITLSFS------------------ ---------PRAREGAHPEAEPQTQPHHL--SQTKPQTNQIQVS---------------- ------------------------------------------------------------ ---------------------GV------------------------------------- ------------------------------------------------------------ ----------------------------------------AHL----------------- -----------------------------PST---------------------------- --------PSCSFLP-------------------------LEK---PRSPRRPRRA---- -TR------PCPTLV-PE----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SSGPPGGAAAKLNQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DLTNVEAKPRM G---------------QQQVEKVHMLNSSHQTN---------------GEMSALEHLSKP GFTKESGCRRRE------------------------------------------------ --------------------------------VSLPPNRTAPLVDKGDKN---------- ------------------------------------------------------------ -----------------------------------------------------------F QISTPLAFTRLNLHRSFSPVG------TSQGSW-SS--RSASPSLSSRSSPLLAAP---- -RSP---N---------G--RAE-PFLEGAEVQVANLDYRMSRKDLQQTLRDTFSRFGQV HSVELSPHTDYQLKAAVQMSSLQQAISAVSGLHRFKIGSKRVQVSLVTGGSNKSL---SL EIISILQDSPANCLPVFKFLEIYEKKYSRKIAVSDLYKLPDLVSVREQGGSRLVCLLPHS QIRQSPLGSS--PSQEGSSSLNGSPVVFEELEYHNPVCEQHYSKQNFSEADFDPESYKIP FVVMSLSTLASELNHLLESHGGTLPLLSFPDCYAAEFSPLILGSE-MTEGAVPLEHLITC VPTVTIVIAQNGFKVIKWLHSRPPAHI-SE------PWIQRCKSPVGNPQLIQFSREIID LLKGQPSCIMPISKFIPAYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKRVAVKDFMQAYHWCFSRDWRVTDYGTCDLMDLLAEI PDTTITISHQSSDTVISVPKR-ER-TTEEVERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLVELFEAIPDILQLLECGEEKVLALTEVERIKALAAQLVKVL RAQKNYSLPVSQLLTEYSRTFGYSLRLQDFDTPSLSTLLAKL-SHVVKVVDSAEGREVQL INRKSLRTLTYQLLALLMS------------------------------------QETDQ LPKGM---------KVEELSQRYQAVHGSPLNPCEYGFLSLSELLKSLPNLMQ------- ---LYHEDNE-ENGKA---------------------------------G--DEYVRLTR LFQFARNVRALLHTYHYNQIFLTEFQGAYSKFMGSSLEPRSYECVSVDDLLNAIPQVVWI KGHGHKRIIVLKNDMK----------------AKASS----------------------- -----SVPSS------PH-----P----AGSP---------------------------- -----------------------------------RDSP-------------------VS GATSGTQS-----------------------------------P---GV----------- ------------------------------------------------------------ ---DDAAES------------------------ELLCL--ASPLDLLCGPVPSCLPSPQL HPNPIAPH-QVDLIHFEGQSASGPAAESGECQAATDGGSNPAEAP--GREEDFPASRAL- ----------------------------------P------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PQ-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SL---------------------------- -----------------------------------------------DSPSRRASRSRIR LAANFSFTSRSSHTSPAD----------------------------------PV >ENSORLP00015021380 M----------------------------------------------------ME----- ---------------GGLGKEK----------------TRATRCPDSPTA-----DASTP QWKLKD---------CFGSN---------------ET---IPPHQIHRN----------- ------------------N-HYMDTRKPLLELKDVP--PP-PQ----H----PPSPHLSK PL-PLRPL----PLPPPPP---------------------------PCFLA--------- ------------PPHLSQDC--QQQQL-------P-----------P------------E G----------------ASPKV--S----HCVYCSTA----------------------- -------------------GRGLLGGGG-----------------DAGGSSSSIAGVVSL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------CRALCSMGD PICSS-----------------------SGSI---------------------------- ------------------------------------------------------------ ------------------------------RSGTCSVVSSVH------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ P----------------------------------------------CQQTLSCNT---- ---------------------RGQVPESVLRLGCNPPLHS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------PVAIAQPLSSHNCLPCCSGLLHTRSAV-------------------------- ------------------------------------------------------------ -------------PSPCSQ--ASSFP---------P------------------------ ---------SVSSLP-----------------------ASVHDSCLVSSGFY-TCDVGCN SSA-R-RSQRS-AHGNQTTATAV--TTTTS------------------------------ ------------------------------------------------------------ ---------TARF----------------------------------------------- --------------------------------------FS--------------N-PIHL NVER-TACVKGAHCCLDYL-K--------------------------------------- ---PVNGV-TSD----TDEVWPKVCVP--QTASL--PVPVCNGCGT---SSDAMALWP-N TSCG-TSYKYG------SPESGGCENIPPVGVFWDIENCNVPSGRSAGAVVQRIRSHFFK GHREAEFICVCDISKESKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-GSHTSSALLQHAHLHVAFQEITADLPQR PLDL-------TEPSFNLLYVHNLPVNCDKSLRNAVKF---------RLRRLSDNCGGKV LG--VSQGIAVLRFGSPEAAARACKRMENEDVFGRRITLSFS------------------ ---------PRSREGTHPEAEPQAQPHHL--SQTKPQTNQIQVS---------------- ------------------------------------------------------------ ---------------------GV------------------------------------- ------------------------------------------------------------ ----------------------------------------AHL----------------- -----------------------------PST---------------------------- --------PSCSFLP-------------------------LEK---PRSPRRPRRA---- -TR------PCPTLG-PE----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SSGPPGGAAAKLNQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DLTFVEAKPRM G---------------QQQVEKVHMVNSSHQSN---------------GEMGTLEHLSKP CFTKESGCRRRE------------------------------------------------ --------------------------------VSLPPNRTAPLVDKGDKN---------- ------------------------------------------------------------ -----------------------------------------------------------F QISTPLAFTRLNLHRSFSPVG------TSQGSW-SS--RSASPSLSSRSSPLLAAP---- -RSP---N---------G--RAE-PFSEGAEVQVANLDYRMSRKDLQQTLRDTFSRFGQV HSVELSPHTDYQLKAAVQMSSLQQAISAVSGLHRYKIGSKRVQVSLVTGGNNKSL---SL EIISILQDSPANCLPVFKFLEIYEKKYSRKIAVSDLYKLPDLVSVREQGGSRLVCLLPHS QIRQSPLGSS--PSQEGSSSLNGSPVVFEELEYHNPVCEQHYSKQNFSEADFDPESYKIP FVVMSLSTLASELNHLLESHGGMLPLLSFPDCYAAEFSPLIIGSE-MTEGAVPLEHLITC VPAVTIVIAQNGFKVIKWLHSRPPAQI-SE------PWIQRCKSPVGNPQLIQFSREIID LLKGQPSCIMPISKFIPAYHHHFAKQCRVSDYGFSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKRVAVKDFMQAYHWCFSRDWRVTDYGTCDLMDLLAEI PDTTITISHQSSDTVISVPKR-ER-TTEEVERTKQFGKEVVDLLRHQPHCRMPFSKFIPT YHHHFGRQCKLSYYGFTKLVELFEAIPDILQLLECGEEKVLALTEVERIKALAAQLVKVL RAQKNYSLPVSQLLTEYSRTFGYSLRLQDFDTPSLSTLLAKL-SHVVKVVDGAEGREVQL INRKSLRTLTYQLLALLMS------------------------------------QETDQ LPKGM---------KVEELSQRYQAVHGSPLNPCEYGFLSLSELLKSLPNLMQ------- ---LYHEDNE-ENVKA---------------------------------G--DEYVRLTR LFQFARNVRALLHTYHYNQIFLTEFQGAYSKFMGSSLEPRSYECVSIDDMLNAIPQVVWI KGHGHKRIIVLKNDMK----------------AKASS----------------------- -----SVPSS------PH-----P----AGSP---------------------------- -----------------------------------RDSP-------------------VS GATSGTQS-----------------------------------P---GV----------- ------------------------------------------------------------ ---DDAAES------------------------ELLCL--GSPLDLLCGPVPSCLPSPQL HPNPIAPH-QVDLIHFEGHSASGLAAESGECQAATDGGSNPAEAP--GREEDFPASRAL- ----------------------------------P------------------------- ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PQ-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SL---------------------------- -----------------------------------------------DSPSRRASRSRIR LAANFSFTSRSSHTSPAD----------------------------------PV >ENSELUP00000002700 -----------------------------------------------------ME----- ---------------G-LGKETSICSSRPIPWLS-H-----------PEK-----EASTR LWKLTD---------CFPAC---------------EQPN-TPSYNTNRQ----------- ------------------KIEYMESRKPILELKDVP--PP-P-----LHTA------ASQ FF-PLAPL----PL--LPP---------------------------PC------------ ------------------------------------------------------------ -PPAPPPESLQPLTQPEGSPDV--SVCSRHCEHCCTDPLG-------------------- -------------------SYGLLSGGG-------------------------------- -----------STSVNSRV----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PV--------------------------------------YL------------------ ------------------------------------------------------------ ----------------------------------------------------------P- ------------------------------------------------------------ -----------------------------------------TSQEASVSRLGSSQIAATL LRPNPPFPSSGGGGGDAQGMLLPSGGYNLPYSSCVAS----------TSQPLPAPQHSHL P----------------------------------------------CS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CCKG------------GLLGPL---------------- --------------------S--------------------------------------- ---------FTSVPLPHNE-------------------------CKFITPSAPLSAPQHG ACN--------------------------------------------------------- ------------------------------------------------------------ -----------RGTAPRYFPSGVDYTPVTRGGLGAPALISDPQSPNVGHVCS-------- ------------------------------------------------------------ ---------------------------------------S--------------NHSVHF NLEH-TVCRTGAHYCRDCFTK--------------------------------------- ---P------------GDKAWPNLPLPSSQSAPT--PVPMCNGCGT---ASDGLLLLG-- SGL-VSGTKYG------SPE--GPENIPPVGVFWDIENCCVPSNRSAAAVVQRLRSRFFQ GHREAEFICVCDISKENKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP AQVVLVSSDVNFASELSDLRHRHGFRVILVHKSGQTSDALLQHATCHVAFEEIVADLPPR QAVK-------PQLGFSLLYVYNLP------------PGRDTKSVSGRLRRLSDNCGGKV LGVSMANGTAVLRFGSQEAAERARKRMENEDVFGRRITLSFS------------------ ---------PTP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------PP----------------- -----------------------------PSS-------KTPPSPSPAHPTP-------- --SFPPL--ASSFLP-------------------------LEK---PRSPRRNRRA---- -RRDGQREREASLPD-PV----------PERPYSPRRG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------S--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EEAPYPGSPRNPTLPQELGSLENKPKM GVFPLEKGLRNASSSPQ--------------SN---------------GD---------- -------------------------GPSRQGPVKAGL------------IGESMFRSGR- ---------------------------RRD------------------------LSSPRS VSDSEHHV---------------------------------ER----GSG---------- ----------------------------------------------------------EF QVSTPSAFSKLTIHRTFSPLVLSHAQGLSQGSW-SS--RSASPCASSRSSPLIGPPPRGA SSSPCRPE---------GSPALE-PFSDGADLQVANLDYRMSRKELQQCLYEAFSRHGRV KGVELSPHTDYQLKATVQMTSLQQAISAVSGLHRYKIGGKRIHVSLVTGAGNKSLAMLTS EIIQILQDAPANCLPLFKFTEIYEKKFGRKLAASDLYRLPEVVAVREQGGGRLVCLLPVG QARQSPLGSS--QSQDG-SSASGSPVVFEELEYHEPVCRLHYPQPNFSEADFDPDSYKIP FVVMSLKGLASHVHCLLQSHEGSLPLLSFPECYESEFGSLAISEEGTVDGGVPLEHLITC IPGINIVTAQNGFKVIKWIHNKPPAPN-TD------AWLQRCKSPVGNPQLIQFSREIID LVKNQPRSLMPLGKFIPAYHHHYAKQCRVSDYGYSKLLELLEAVPHVLQILGMGNKRMLT LTHRAQVKRFTQDLLKLLKFQASKQVEVKDFMQAYHWCFSRDWQVLDYGMCDLMDLLAEI PDTTITITQQDVDTVISVPKR-ER-TTDEIERTRQFAKEVVDLLRHQPHCRMAFSKFIPT YHHHFGRQCKLTYYGFTKLIELFEAIPDVLTVLECGEEKVLMLTEMERVKALAAQLVKLL RSQRDSSLPAAQLLSEYSKTFGYGLRLQDYDVSSLPALLVKL-CHVVKVVDGANGREVQL INRKSLRSLTCQLLALLM------------------------------------------ ---GLGQHEGDGSVSVEGLSLLYQSVHGLQLNPCEYGFLSLSELLKSLPYLVE------- ---LFYDKGE-EEGE---------------------------------RG--EERVRLTR LYQFARSVRALLHTYHYHQIFLTEFPGAYAKFTGRSLQPRSYGYATVDDLLNAIPQVVWI KGHGHKRIIVLKNDMKA---------------VRATG----------------------- -----S------------------------SPAASEDPEDGNRDGTGTNPE--------- --------AGPLI---------------QGGGA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------VEA------------------------ELLCL--SSPLDLLCGPVPSCLPSPQL HPDPILLE-PADLIRFE------------------------------------------- --------------------------------QTPS------------------------ ------------------------P----------------------------------- --------------------------------------AESNTQVEEAVAEMAAPTVCSD ----------------------GPKEGPLTVDHQNRVPLVSAATKSPHSAGLKMETA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -E---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------NSPGRRAPRNKVK LAANFSFTAS-------------------------------------------H >ENSHHUP00000021979 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MDNRKPVLELKDLP--PP-P-----HHTA------ASQ PF-PLAPL----PL---TP---------------------------PRLPP--------- ---------------LPQDSL-QEL---------P-----------------------QQ G----------------VSPKV--SVCT-HCEHCSTDPLGWGGYGVVSGGGSAGISSG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------LHIPSVDTTSQPLPFQ----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------PLH--------------- --------------------S--------------------------------------- ---------YPSIPLPYNE-------------------------SKFITTSAPLSTPHHG TCNLGIPA-----------------------------------------GYY-PCG---- ----------------------------------------------GDYNPATVGVQRSL AAHSDPHIPTS------------------------------------GHICS-------- ------------------------------------------------------------ ---------------------------------------S--------------N-AMHF NLER-TVCRTGAHYCRDCLTK--------------------------------------- ---P------------ADKLWPNIPLPPAQSASV--PIPMCNGCGT---SSDGLLLLG-- SGLGKSATKYGMYHCNDASQ--GPENIPPVGVFWDIENCCVPSGRSAAAVVQRLRSYFFQ GHREAEFICVCDISKENKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVHKSGQTSDALLQHAHRHVAFEEMVADLPPR QAVK-------SQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------L MS-----------------SLLSPI--RRD------------------------LSSPRS ASDSERHV---------------------------------DR----SSG---------- ----------------------------------------------------------EF EVSTPSAFSKLTLLKTFSSS---------------------------------------- --------------------ASE-PFSDGADLQVANLDYRMSRKELQQSLHDAFSRHGRV KGVELSPHTDYQLKATVQMVSLQQAISAVSSLHRYKIGSKRIHVSLITGAGNKSLAMLRS EIFQILQDAPASCLPLFKFTEIYEKKFGRKLVVSDLYRLQEVVAVREQGGGRLVCLLPSS QARQSPLGSS--QSQEG-SSANGSPVVFEQLEYHEPVCRYHYTQQNFSEADFDPDSYKIP FVVVSLKTLASQVHCLLQSHEGTLPLLSFSECYASELGPLAVSEEGEEEGSVPLEHLITC IPGINIITAQNGFKVIKWIHNKPPASN-TD------QWTQRCKSPVGNPQLIQFSRELID LMKGQPCNLMPISKFIPAYHHHYAKQCRVSDYGYSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAITDFMQAYHWCFSRDWRVLDYGMCDLMDLLAEI PDTTITITHQDLDTVISVPKR-DR-TSDEMERTKHFGKEVVDLLRHQPHCRMAFSKFIPT YHHHFGRQCKLAYYGFTKLLELFEAIPDVLVVLECGEEKVLTLTEVERVKALAAQLVKIL RSQRDSSLPAAQLLSEYSKTFGYGLRLQDYDVSSLPALLINL-CHVVKVVDGANGREVQL INRKSLRSLTCQLLSLLM------------------------------------------ ---GLGQHEGDGSVSVEGLSLLYHSVHGVQLNPCEYGFLSLSELLKSLPYLVE------- ---V---------GE---------------------------------RG--EERVGLTS LYQFARSVRALLHTYHYHQIFLTEFPGAYAKFTERGLQPRSYGYGSVDDLLNAIPQVVWI KGHGHKRIIVLKNDMK----------------ARATG----------------------- -----A------------------------SPAASEEPED-------------------- -------------------------------GASQRDSP-------------------CS NTESGTHS-----------------------------------P---------------S VG---------------------------------------------------------- -----GVET------------------------ELLCL--TSPVDLLCGPVPSCLPSPQL HPDPV-LQ-QADLIRFE------------------------------------------- --------------------------------PTPS------------------------ ------------------------P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----EAVAEEVAAPAVCDTSEPIEPLTDNNQNVVVLVSTTTKP---------------- --------------------------PQ-------------------------------- ----------------------------------------------------NVTCKMAS VE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------NSPSKRAPRNKVK LAANFSFTAA-------------------------------------------P >ENSHHUP00000031637 M----------------------------------------------------ME----- ---------------G-LGKERSICSSRPFPWLS-H-----------PEK-----VASSR LWKLTD---------CFSTS---------------EQQN-TPSYNTDKQ----------- ------------------N-DYMDNRKPVLELKDLP--PP-P-----HHTA------ASQ PF-PLAPL----PL---PP---------------------------PCLPP--------- ---------------LPQDSP-QEL---------P-----------------------QQ G----------------GSPKV--SVCT-HCEHCSTDPLGRGGYGVVSGGGSAGISSG-- ----------------VGVSSG-------------------------------------- ------------------V----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PL--------------------------------------YL------------------ ------------------------------------------------------------ ---------------------------------------------------------PP- ------------------------------------------------------------ -----------------------------------------SSQEASFSRLGASQITPTT LNSHPHFPSLGGGGGDARATLLPSG-----------SYKLHIPSVDTTSQPLPFQSHSHL P----------------------------------------------CS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------CCTG------------GLLRPLH--------------- --------------------S--------------------------------------- ---------YPSIPLPYNE-------------------------SKFITTSAPLSTPHHG TCNLGIPA-----------------------------------------GYY-PCG---- ----------------------------------------------GDYNPSTVGVQRSL AAHSDPHVPIS------------------------------------GHICS-------- ------------------------------------------------------------ ---------------------------------------S--------------N-AMHF NLER-TVCRTGAHYCRDCLPK--------------------------------------- ---P------------ADKLWPNIPLPPAQSASV--PIPMCNGCGT---SSDGLLLLG-- SGLGKSATKYG------SPE--GPENIPPVGVFWDIENCCVPSGRSAAAVVQRLRSHFFQ GHREAEFICVCDISKENKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVHKSGQTSDALLQHAHRHVAFEEMVADLPPR QAVK-------SQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELGGLETKPKI GGFPLEKGQRN--SSPH--------------SN---------------GE---------- -------------------------GPSQQHPIKAGL------------IGESMFRC-R- ---------------------------RRD------------------------LSSPRS SSDSERHV---------------------------------DR----SSG---------- ----------------------------------------------------------EF QVSTPSAFSKLTLLKTFSSSVLPQPQGLSQGAW-SS--RSGSPCMSSRSSPLIGPPPRG- SSSPCLPV---------GAQASE-PFSDGADLQVANLDYRMSRKELQQSLHDSFSRHGPV KGVELSPHTDYQLKATVQMVSLQQAISAVSSLHRYKIGGKRIHVSLITGAGNKSLAMLRS EIFQILQDAPASCLPLFKFTEIYEKKFGRKLVVSDLYRLQEVVAVREQGGGRLVCLLPSS QARQSPLGSS--QSQEG-SSANGSPVVFEQLEYHEPVCRYHYTQQNFSEADFDPDSYKIP FVVVSLKTLASQVHCLLQSHEGTLPLLSFSECYASELGPLAVSEEGEEEGSVPLEHLITC IPGINIVTAQNGFKVIKWIHNKPPVSN-TD------QWTQRCKSPVGNPQLIQFSRELID LMKGQPCNLMPISKFIPAYHHHYAKQCRVSDYGYSKLLELLEAVPHVLQILGMGTKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVAITDFMQAYHWCFSRDWRVLDYGMCDLMDLLAEI PDTTITITHQDLDTVISVPKR-DR-TSDEMERTKHFGKEVVDLLRHQPHCRMAFSKFIPT YHHHFGRQCKLAYYGFTKLLELFEAIPDVLVVLECGEEKVLTLTEVERVKALAAQLVKIL RSQRDSSLPAAQLLSEYSKTFGYGLRLQDYDVSSLPALLVNL-CHVVKVVDGANGREVQL INRKSLRSLTCQLLSLLM------------------------------------------ ---GLGQHEGDGSVSVEGLSQLYHSVHGVQLNPCEYGFLSLSELLKSLPYLVE------- ---XFYGKGE-EEGE---------------------------------RG--EERVRLTR LYQFARSVRALLHTYHYHQIFLTEFPGAYTKFTGRGLQPRSHGYGSIDDLLNAIPQVVWI KGHGHKRIIVLKNDMKA---------------ARATG----------------------- -----A------------------------SPAASEEPED-------------------- -------------------------------GASQRDSP-------------------CS NTESGTHS-----------------------------------P---------------G VG---------------------------------------------------------- -----GVET------------------------ELLCL--TSPVDLLCGPVPSCLPSPQL HPDPV-LQ-QADLICFE------------------------------------------- --------------------------------QTPS------------------------ ------------------------P----------------------------------- --------------------------------------AE-------------------- --------------------------------------------------------RDKP ---EEEAVAEEVAAPAVCDTSEPIEPLTDNNQNVVVLVSTTTKP---------------- --------------------------PQ-------------------------------- ----------------------------------------------------NVTRKMAS VE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------NSPSKRTPRNKVK LAANFSFTAA-------------------------------------------P >ENSIPUP00000024136 -----------------------------------------------------ME----- ---------------G-SGKERKVCDGRSFPWLT-H-----------TD---------NR FWKLAD---------CFSSL---------------QK---TAP-STPHQ----------- ------------------N-SYMEVRKPVLELKDVP--PP-PL----HSASQ-------Q PL-ALAPQ----PA---PP---------------------------PCQ----------- --------L-------------------------PASDPQLPQQTVP------------- --------QLQP-----GSSKV--SLCS-CCE---------------------------- ------------------------------------------------------------ ------------------------CSLHVQQHSGSLEARAHSFGGGCSVSSNTNASTGGG ------------------------------------------------------------ -------------------------L---------------------------------- ------------------------------------------------------------ PA------------------------------------------------------LF-- ------------------------------------------------------------ ---------------------------------------------------------SPA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------QLQTPQSFGF RVA--------------------------------------------------------- -------SVATSQPMAAHTHPSYCG-----------------HLH--------------- -TCS--SVGCLQPKHVSGS----------------------------------------- ------------------------------------------------------------ --------------------------------------APIHGPCVALSG---------- ------------------------------------------------------------ RCH-----------------------------------------------CSEEHRVEQH YHSLSDAPSSTHL----------------------------------------------- --------------------------------------CT--------------N-PLYL --EHNSGCQKGAHYCHQCLRK--------------------------------------- ---PTQGLGAAD----SEKVWPNIPPPQPCSATL----PMCNGCRVPGTSNDGI--LH-P TSVGKITQKYG------SIEGGGQESLPPVGVFWDIENCAVPSGRSAATVVQRLRERFFQ GHREAEFICVCDISKENKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVIVVSSDVNFASELSDLRHRHGFKVILVH-KTQASPALLQHAHLHVLFEDFVSELPPR MLIK-------SQPCFNLLFVHNLPTHRD------------AKSVSSRLQRLSNNCGGKV LG--VSGGTAVLRFASAEAAERARKRMENEDVLGNRISVSFS------------------ ---------P------------------------------------DGL----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------QEE------EEA E------------------------RSR-P------------------------VASSSF SSAL--------FLP-------------------------VEK---PRSPRRPRRA---- -MR------ASQ-------SGKDAGVNVPERPYSPRKV---------------------- -------------------------GHASSCSPVLKSLSQ-------------------- ---------------------------------------DASGMESKPRTGFPLEKVRAA SASPQSNGLTSQLQPAKPAFPAELLQRGRRRDT--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CSVRSTTDSPAE--------------------- ----------------------------------------------------------SF QVSTPSAFSKLNLHTSFSPLM------FSQGSW-SS--RSASPCLSNRSSPLSVPS---- -RSPC-PD---------S--QPE-PFSDGADIQVANLDYRMSRKELQQILLDTFAKHGRV KSVELSPHTDYQLKAKVQMGSLQQAIGAVSILHRYKIGNKRVNVSLITGANNKSLTCLSS EIISILQDSPANCLPLFKFSEIYEKKFGRKLVASDLYRLPEVVAVREQGAGRLVCLLSNS LVRHSPLGSS--QSYDG-SSTSGSPVVFEELEYHEPVCKRHYTQQDFSEADYDPDTYKIP FVVVSLKALSAHVHSLLQSHEGTIPLLSLPECYASEFSPLTMEEEGKLEGSVPLEHLITC IPGITIVTAQNGFKVIKWIHNKPPPPN-AD------PWLQRCKSPVGNPQLIQFSREIID LMKNQPCCLMPITKFVPAYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGLGSKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVIIRDFMQAYHWCFSRDWHVVEYGMCDLMDLLTEI PDTTITITQQDSDTVISVPKR-ERGTTEEMERTRQFGKEVVDLLRHQPHFRMPFSKFIPT YHHHFGRQCKLTYYGFSKLVELFEAIPDVLQVLECGEEKVLALTEVERVKALAAQLVKLL RAQRDCALPVSQLLAEYSKTFGYGLRLQDYDASTLPALLAKL-CHVVKVVDGAEEKVVQL INRKSLRALTSQLLAVMMSLPDAHNWLGVEALQKQ------------------------- ----------------------YESMYDQQLNPCEYGFVSLTELLKSLPYLVE------- ---LFEEEED-D------------------------------------EA--KDRVRLTQ LYQFARKVRALLHTYHYNQIFLTEFRGAFSKYTGHEFQPRDYGYSSLDELLAAIPQVVWI KGHGHKKIIVLRNDMK----------------ARSSP----------------------- -----ASTES------PQ-----L--------------------------EEARESQSPA S-----T-----------------------------HSPASGGSTG-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------EA------------------------ELLCMSSGSPVDLLCGPVPSCLPSPQL HPDPVLLQ-HRDLIRFDE------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------HSHSQPTGGTREDQPVHDRQPRAAMTATERCTASNEENETVGTSDPTNS DEKNSECQSGNTKSSDT------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PSQPPNL--------------------KPSAT---------------------------- -----------------------------------------------ESPSKRNFRNKIK LAANFSFSTN-----------------------------------------PSV >ENSAMXP00000011517 M----------------------------------------------------MD----- ---------------G-LGKEKSICSSGSFPWLN-H-----------LNS-----EAPSR VWKLTD---------CFSSP---------------KQ---TTP-ASQPQ----------- ------------------S-SYMEVRKPVLELKDVP--PP-PL----HSASQ-------Q PL-PLAPL----PV---PP---------------------------PCH----------- --------L-------------------------P------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------PDPRPPQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GQTLALPLSQPRSTSPKVSLCSRCE----------- ---------------------------------------SSLLLQQTHGLLEARSHSFGD PGGGCSISSNANANVGGGGLPTLHFSHTQGSTLSGQSTATPSSAPYLPSPQLQTPESFGL KKP--------------------------------------------------------- -------SVATSQPMAAHSQPSCCAG-L-------------RHLH--------------- -TCPSLSVGCVQSSHVPGSGS--------------------------------------- ------------------------------------------------------------ --------------------------------------ASIHEPCMTSSG---------- ------------------------------------------------------------ YGH-----------------------------------------------CSGECRLEQN SHSHSDAPPSTHL----------------------------------------------- --------------------------------------CS--------------N-PLHL SVEHSAVCLKGAHYCHQCLSK--------------------------------------- ---PVQGLDATN----SAKVWPNIPPPHAQSAPV----PVCNGCGVPGSSTDGIL-LH-T ASLNKVNHKYG------TPENSGQESLPPVGVFWDIENCAVPSGRSAAIVVQRLRDRFFQ GHREAEFICVCDISKENKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVIVVSSDVNFASELSDLRHRHRFQVILVH-KSQASLALLQHAHVHVPFEDFVSELPPR MLIK-------SQPCFNLLFVHNLPTHRD------------AKAVSSRLQRLSNNCGGKV LG--VSGGTAVLRFASAEAAERAAKRMENEDVLGNRITVSFS------------------ ---------P------------------------------------DGR----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------QQE------EEE E------------------------RIRLP------------------------VSSSSS SAAL--------FLP-------------------------LEK---PRSPRRPRRV---- -SR------SCQ-------SGRDAGVNIPERPYSPRKG---------------------- -------------------------GHASSCSPVMKLLPQ-------------------- ---------------------------------------DASALDSRPRTGFTLEKSRAA SMSPQSNSLTSQMQPSKPGFPAELLHRSRRRDS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CSLRSVTDSPVE--------------------- ----------------------------------------------------------PF QVSTPSAFSKLSLHTSFSPML------LSQGSC-SS--RSASPCLSNRSSPLSVQS---- -RSPC-LD---------S--RPELPFSDGADIQVANLDYRMSRKELQQILLDTFAKHGRV KNVELSPHTDYQLKAKVQMGSLQQAIGAISILHRFKIGNKRIHVSLLTGANSKSLACLSS EIISILQDSPANCLPLFKFTEIYEKKFGRKLVVSELYRLPEVVAVREQGGSRLVCLLSSS IARHSPLSSS--QSHDG-SSTSGSPVVFEELEYHEPVCKRHYTQQDFSEADYDPDTYKIP FVVVSLKALSAHVHCLLQSHEGTVPLLSFLECYAAEFSPLTVGEEGTLEGSVPLEHLITC IPGITIVTAQNGFKVIKWIHNKPPPSN-AD------PWLQRCKSPVGNPQLIQFSREIVD LMKSQPSCLMPITKFIPAYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGLGSKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVVIRDFMQAYHWCFSRNWHVVDYGMCDLMDLLTEI PDTTISITQQDSDTVISVPKR-ER-TPEEVERTKQFGKEVVDLLRHQPHFRMPFSKFIPT YHHHFGRQCKLTYYGFSKLMELFEAIPDVLQVLECGEEKVLALTEVERVKALAAQLVKLL RAQRDCSLSVNQLLAEYSKTFGYGLRLQDYDACTLPALLAKL-CHVVKVVDGADGKEVQL INRKSLRALTSQLLAIMMSLPDEHNWLEVEALRRQ------------------------- ----------------------YELMFDIPLNPWEYGFVSLCELLKSLPYLVE------- ---MFVGECDND---------------------------------A--KP--EEGVRLTR LYQFARNVRALLHTYHYNQIFLTEFWGAFSKYTGREFQPREYGYSTLDELLAAIPQVVWI KGHGHKKIIVLRNDMK----------------ARVSP----------------------- -----ANTET------PQ-----P--------------------------EEVRESQSPA STQDSGT-----------------------------HSP--GGSTG-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------DA------------------------ELLCLNSASPVDLLCGPVPSCLPSPQL HPDPVLLQ-NSDLIHFEE------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------RSQPQ-------------------------------- ------------------------------------------------------------ ---LTGGAAEQH------------QPVHDRQPQAALS-------------------P--- ------------------------------------------------------------ --------------SSYTSDRLSVSDVENGTPETSSTSSVQDEGRSNTDAESHSTAG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SGVTK PPQPPNL--------------------KPHAT---------------------------- -----------------------------------------------DSPSKRHSRNKVR LAANFSFSPA-----------------------------------------PSV >ENSAMXP00005002082 M----------------------------------------------------MD----- ---------------G-LGKEKSICSSGSFPWLN-H-----------LNS-----EAPSR VWKLTD---------CFSSP---------------KQ---TTP-ASQPQ----------- ------------------S-SYMEVRKPVLELKDVP--PP-PL----HSASQ-------Q PL-PLAPL----PV---PP---------------------------PCH----------- --------L-------------------------P------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------PDPRPPQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GQTLALPLSQPRSTSPKVSLCSRCE----------- ---------------------------------------SSLLLQQTHGLLEARSHSFGD PGGGCSISSNANANVGGGGLPTLHFSHTQGSTLSGQSTATPSSAPYLPSPQLQTPESFGL KMP--------------------------------------------------------- -------SVATSQPMAAHSHPSCCAC-L-------------RHLH--------------- -TCPSLSVGCVQSSHVPGSGS--------------------------------------- ------------------------------------------------------------ --------------------------------------ASIHEPCMTSSG---------- ------------------------------------------------------------ YGD-----------------------------------------------CSGECRLEQN SHSHSDAPPSTHL----------------------------------------------- --------------------------------------CS--------------N-PLHL SVEHSAVCLKGAHYCHQCLSK--------------------------------------- ---PVQGLDATN----SAKVWPNIPPPHAQSAPV----PVCNGCGVPGSSTDGIL-LH-T ASLNKVNHKYG------TPENSGQESLPPVGVFWDIENCAVPSGRSAAIVVQRLRDRFFQ GHREAEFICVCDISKENKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVIVVSSDVNFASELSDLRHRHRFQVILVH-KSQASLALLQHAHVHVPFEDFVSELPPR MLIK-------SQPCFNLLFVHNLPTHRD------------AKAVSSRLQRLSNNCGGKV LG--VSGGTAVLRFASAEAAERAAKRMENEDVLGNRITVSFS------------------ ---------P------------------------------------DGR----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------QQE------EEE E------------------------RIRLP------------------------VSSSSS SAAL--------FLP-------------------------LEK---PRSPRRPRRV---- -SR------SCQ-------SGRDVGVNIPERPYSPRKG---------------------- -------------------------GHASSCSPVMKLLPQ-------------------- ---------------------------------------DASALDSRPRTGFTLEKSRAA SMYPQSNSLTSQMQASKPGFPAELLHRSRRRDS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CSLRSVTDSPVE--------------------- ----------------------------------------------------------PF QVSTPSAFSKLSLHTSFSPML------LSQGSC-SS--RSASPCLSNRSSPLSVQS---- -RSPC-PD---------S--RPELPFSDGADIQVANLDYRMSRKELQQILLDTFAKHGRV KNVELSPHTDYQLKAKVQMGSLQQAIGAISILHRFKIGNKRIHVSLLTGANSKSLACLSS EIISILQDSPANCLPLFKFTEIYEKKFGRKLVVSELYRLPEVVAVREQGGSRLVCLLSSS IARHSPLSSS--QSHDG-SSTSGSPVVFEELEYHEPVCKRHYTQQDFSEADYDPDTYKIP FVVVSLKALSAHVHCLLQSHEGTVPLLSFLECYAAEFSPLTVGEEGTLEGSVPLEHLITC IPGITIVTAQNGFKIIKWIHNKPPPSN-AD------PWLQRCKSPVGNPQLIQFSREIVD LMKSQPSCLMPITKFIPAYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGLGSKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVVIRDFMQAYHWCFSRNWHVVDYGMCDLMDLLTEI PDTTISITQQDSDTVISVPKR-ER-TPEEVERTKQFGKEVVDLLRHQPHFRMPFSKFIPT YHHHFGRQCKLTYYGFSKLMELFEAIPDVLQVLECGEEKVLALTEVERVKALAAQLVKLL RAQRDCSLSVNQLLAEYSKTFGYGLRLQDYDACTLPALLAKL-CHVVKVVDGADGKEVQL INRKSLRALTSQLLAIMMSLPDEHNWLEVEALRRQ------------------------- ----------------------YELMFDIPLNPWEYGFVSLCELLKSLPYLVE------- ---MFVGECDND---------------------------------A--KP--EERVRLTR LYQFARNVRALLHTYHYNQIFLTEFWGAFSKYTGREFQPREYGYSTLDELLAAIPQVVWI KGHGHKKIIVLRNDMK----------------ARVSP----------------------- -----ANTET------PQ-----P--------------------------EEVRESQSPA STQDSGT-----------------------------HSP--GGSTG-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------DA------------------------ELLCLNSASPVDLLCGPVPSCLPSPQL HPDPVLLQ-NSDLIHFEE------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------RSQPQ-------------------------------- ------------------------------------------------------------ ---LTGGAAEQH------------QPVHDRQPQAALS-------------------P--- ------------------------------------------------------------ --------------SSYTSDRLSASDVENGTPETSSTSSVQDDGRSNTDAESHSTAG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SGVTK PPQPPNL--------------------KPHAT---------------------------- -----------------------------------------------DSPSKRHSRNKVR LAANFSFSPA-----------------------------------------PSV >ENSPNAP00000037907 M----------------------------------------------------ME----- ---------------G-LGKERSICNAGSFPWLN-H-----------LDS-----ETPSK VWKLTD---------CFSSL---------------KQ---APP-ASQPQ----------- ------------------N-SYMEVHKPVLELKDVP--PP-PL----HSASQ-------Q SL-PLASL----PV---PP---------------------------PCH----------- --------L-------------------------P------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------PDPRPPQVQPGS------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PK------------SSTFTGQPTV------------------------------------ ------------------------------------------------------------ ---------------------------------------TPSSAPYRPSLQLQTPQSFGL QMP--------------------------------------------------------- -------SVATSQPVAAHSHCSCCSG-L-------------RPLH--------------- -ACPSLSVGCVQSNHVPGS----------------------------------------- ------------------------------------------------------------ ---------------------------------------AIHGPCVASSG---------- ------------------------------------------------------------ CCH-----------------------------------------------CSGECQAEQH SHSHGDASSSTHL----------------------------------------------- --------------------------------------CS--------------N-PLHL NVEHTTVCLKGAHYCHQCLRK--------------------------------------- ---PVQGLGAAD----SVKVWPNIPPPQTQTAPL----PVCNGCGVPGASTDGVH-LH-T TSLGKINQKYG------SPESSGQEALPPVGVFWDIENCAVPSGRSAATVVQRLRERFFQ GHREAEFICVCDISKENKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTTP ATVIVVSSDVNFASELSDLRHRHGFQVILVH-KSQASPALLQHAHLHVPFEDFVSELPPR MLMK-------SQPCFNLLFVHNLPTHRD------------AKAVSSRLQRLSNNCGGKV LG--VSGGTAVLRFASAEAAERAAKRMENEDVLGNRITVSFS------------------ ---------P------------------------------------DGP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------QQE------EEE E------------------------RIQLP-----------------------TASSSSS SAAV--------FLP-------------------------LEK---SRSPRRPRRV---- -SR------SCQ-------SGRDVGVNIPERPYSPRKG---------------------- -------------------------GHASSCSPVMKLLPQ-------------------- ---------------------------------------DVSGVESRPRTGFALEKSRAA SASPQNNGLAAQLQSAKPGFPTELLHRGRRRDS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------CSLRSVTDSPME--------------------- ----------------------------------------------------------PF QVSTPSAFSKLNLHTSFSPLM------FSQG---SS--RSTSPCLSNRSSPLSVAS---- -RSPC-PD---------T--HPE-PFSGGADIQVANLDYRMSRKDLQQILLDTFAKHGRV KCVELSPHTDYQLKAKVQMGSLQQAIGAVSILHRYKIGNKRIHVSLITGANNKSLACLSS EIISILQDSPANCLPLFKFTEIYEKKFGRKLVVSELYRLPEVVAVREQGGSRLVCLLSSS LTRHSPLGSS--QSHDG-SSTSGSPVVFEELEYHEPVCKRHYTQHDFSEADYDPDTYKIP FVVVSLKALAAHVHSLLQSHEGTVPLLSFLECYAAEFSPLTVAEEGKLEGSVPLEHLITC IPGITIVTAQNGFKVIKWIHNKPPPPN-AD------PWLQRCKSPVGNPQLIQFSREIID LMKSQPSCLMPITKFIPAYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGMGSKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVVIRDFMQAYHWCFSRNWHVVDYGICDLMDLLTEI PDTTITITQQDSDTVISVPKR-ER-TVEEVERTKQFGKEVVDLLRHQPHFRMPFSKFIPT YHHHFGRQCKLTYYGFSKLMELFEAIPDVLQVLECGEEKVLALTEMERVKALAAQLVKLL RAQKDCSLPVNQLLAEYSKTFGYGLRLQDYDANTLPALLSKL-CHVVKVVDGAEEKEVQL INRKSLRALTSQLLAVMMSLPDERNWLGVEALREQ------------------------- ----------------------YESMYDTALNPCEYGFVSLSELLKSLPYLVE------- ---LFEGESD-D---------------------------------G--KA--EEQVRLTC LYQFARNVRALLHTYHYNQIFLTEFWSAFSKYTGREFQPRDYGYNTLDELLAAIPQVVWI KGHGHKKIIVLRNEMK----------------ARSSP----------------------- -----ANTES------PQ-----P--------------------------EEVRESQSPA STQDSGT-----------------------------HSP--GGSTG-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------DA------------------------ELLCLKSTSPVDLLCGPVPSCLPSPQL HPDPVLLQ-HKDLIRFEE------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------HSHHQPTGGVGQRQPVHNRQPQAALT-------------------PTNC ----------------TPERHTASDVENGMADSSTTVTVVLSVGDSYSSCVQDDIGSKTA HTDSHGTAGLTVTM---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PPQAPNL--------------------KPSAT---------------------------- -----------------------------------------------DSPSKRPLRNKVR LAANFSFSTA-----------------------------------------PSI >ENSDARP00000151473 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MEVCKPVLELKDVP--PP-PV----HSG---------- -----VPQAHACPA---PPHTPPGLSVSVCSMCELLLPACAALRPLPC------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PGSALCLCRRAPHSFPRAEPPVCPSALHTPLCVAAAHCVQDCWRQ GVRVD------------------------------------------------------- ------------------------------------------------------------ P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------EKVWPNIPPP------V----PVCNGCGATGAPTDGLLGVH-- --LGKPVQKYG------PAESSTQESLPPIGVFWDIENCAVPSGRSAAAVVQRLRERFFQ GHREAEFICVCDINKENKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVIVVSSDVNFGSELSDLRHRHGFQVILLH-KSQASPALLQHAHRCAAFEELVSGLPPG MQVR-------TQPSVSLLFVHRLPMHRD------------AKAVANRLQRLSNNCGGKV LG--VSGGCAVLRFASAEAAERARKRMENEDVLGQRILVSHS------------------ ---------R------------------------------------DGPDEGEEL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPPTAAAA------------ ------------------------------------------------------------ -AAL--------FMP-------------------------VEK---LRSPRRQRRA---- -SR------SCH-------A--------PERPYSPRNA---------------------- -------------------------GHASSCSPVMKPLPQAVCGATRPATASPQSNTLL- -----------------------------SAPGRPVEPP--------------------- -------------------------QRSRRR----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------DSPGQ--------------------- ----------------------------------------------------------LF QVSTPSAFSKLSLQRSFSPMM------LSHSSW-SS--RSASPCPSSRSSPRSAPS---- -PSGC-AD------------EPQ-PFSDGADLQVSNLDYRLPRTELQQSLRDAFARHGRV KSVDLSPHTDYQLKARVHMSSLQQAISAVSLLHRYKIGSKRIQVSLVTGASNKSLTCLSS EIISILQDAPANCLPLYKFTETYERKFGHKLAVGDLYRLPELVCVREQGGGRLVCLLSNT QIRQSPLGSSHTHTHDS-SNTA-SPVLFEELEYHEPVCKRHSAQQDFSEADFDPDSYMIP FVLESLKVLAAHVHSLLQSHEGMLPLLSFPDCYAAEFSALSVAEEGQLEGSVPLEHLITC IPGVTIVTAQNGFKVIKWIHNKPPPPN-AD------LWLQRSKSPVGNPQLIQFSREMVD LMRSQPSCLMPVSRFIPAYHHHFAKQCRVSDYGYTKLLELLEAVPHVLQILGLGSKRLLT LTHRAQVKRFTQDLLKLLKMQASKQVSLQGFGSAYHWCFSRDWQVVDYGMCDLMDLLSEI PDSTISVCQQDADVIISVPKR-ER-SAEEAERTRQFGREVVDLLRHQPHFRMAFSRFIPT YHHHFGRQCKLSYYGFSKLMELFEAIPDILQVLECGEERLLVLTEVERVKALAAQLVKLL RAQRDSGLPVCRLLGEYSKTFGYCLRLQDYEASTLPALLHRL-CHVVKVVDTPEGKEVQL INRKSLRALTSQLLALMMSLPEERSDVCVEELRCQ------------------------- ----------------------YELSYGAPLNPCEYGFISLAELLKSLPYLLQ------- ---LSEDE-------------------------------------G--GG--NERVRLTR LYQFARRVRALLLTFHYSQLFLSEFSSAFSKHSGETLHTHNYGYNTLEELLAAIPQVVWI KGHGHKKIIVLKNDMR----------------ARGSP----------------------- -----ALTDS------PADEPHPE--------------------------EEPRATTSPA S--------------------------------------------G-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------EL------------------------ELLCLSSSSAVDLLCAPVPSCLPSPAL RPDPV------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --QPPDLMHFQPPVNHQPRPANGSDPAQPSAG---------------------------- ---------------------------------------------VWDSPARRSARSRVR LAANFSFTAA-----------------------------------------QPV >ENSCHAP00000022572 -----------------------------------------------------ME----- ---------------E-LGKERSICSARSFSWLE-P-----------PENVKVTLAPPSK FWKLSD---------CFSS---------------------TVP-TTANQ----------- ------------------N-NYMDSQPPVLELKDVP--PP-PL----PAASQ-------- PF-PLAPL---------PP---------------------------PCLPS--------- -----RGSL-------------------------A-----------P------------- --------PLQP-----GSPKV--STCS-QCE---------------------------- ------------------------------------------------------------ ------------------------ASLHPQ----------------------------SG LDLLGSQARGFGDLCGGGSSITGGAGGGSILFSKPLGAAHAWAACQAASSSSNTSTSAPS SSSSSSTVPHHLSLLSGHAGQVPSSL---------------------------------- ------------------------------------------------------------ P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------SVATSQPVASLSQLPCCSGLL-------------KPLHA-------------- PTCP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QLSQAYGQPMYGSCPAAPSSGYYRYGGELGSGTAGKQPQHPHHHHHGGL STSPAPV-------------------------------CS--------------H-PLHH GIKR-TVCLKGVHYCQDCLSK--------------------------------------- ---PAQGL-VSE----PAKLWPNIPPPHAQSAPI--PVPMCNGCGVTGASTDGLL-LL-G SSLGKTSQKYG------SPDSGTQESLPPVGVFWDIENCSVPTGRSAASVVQRLRARFFP GHREAEFICVCDISKENKDVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFADTHTAP ATVVLVSSDVNFASELSDLRHRHGFQVILVH-KNQVSGALLQHAHRHVAFEEFLSGLPPR MPLK-------SQPGFNILFVHNLPTNRD------------GKSVANRLRRLSDNCGGKV LG--LSAGTAVLRFSSLEAAERARKRMENEDVYGCRIHVSFS------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------PEEE QGGGGGGGEGEEEGDNNDDDDDSVRRVQLPSV------------------LPSSSSSSSL SAAL--------FLP-------------------------VEK---PRSPRRPRRAGAGA HIR------PCQ-------VASY---TVPERPYSPRKG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------GGPH--AASRPTQ-------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------ELGPAETKPRM GFLS-DKG-RTSSASPH--------------SN---------------GET--------- ------------------------------------------------------------ -TLQNHQRAGLAGDAPYRGK-------RRD------------------------LS---- ------------GSPHAPARRD----LSGVRSATDSPAE--------------------- ----------------------------------------------------------PF TVSTPSAFSKLSLQRSFSPML------LSQGSW-SS--RSGSPCLSNRSSPLSAPR---- --SPG-PDA-------NA--SAE-PFSDGADIQVSNLDYRMSRKELQQILQDTFAKHGKV KGVELSPHTDYQLKATIQMSSLQQAIGAIGALHRYKIGGKRIQVSLLTGANNKSLTVFSS EIISILQDAPASCLPLFKFTEIYEKKFGHKLVVSELYRLPEVVAVREQGGGRLVCLLPNS QARQSPLGSS--QSHDG-SSASGSPVVFEELEYHEPVCKRHYTQSSFSEADYDPDSYKIP FVVVSVKTLAAQVHSLLQSHEGTIPLLSFPECYATEFSPLTVGEEGELEDGVPLEHLITC IPGVTVVTAQNGFKVVKWIHNKPPPPN-AGKEACQYPWVPRCKSPVGNPQLIQFSRELVD LLKGQPSCLMPLSRFIPAYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGLGSKRLLT LTHRSQVKRFTQDLLKLLKFQASKQVVIRDFMQAYHWCFSRDWSVIDYGMCDLMDLLTEI PDTTITITQQDDDMVISVPKR-ER-TAEEQERTRQFAKEVVDLLRHQPHFRMAFSKFIPT YHHHFGRQCKLTHYGFTKLVELFEAIPDVLMVLECGEEKVLCLTEVERVKALAAQLVKLL RAQRDCRLPVQQLLAEYSKTFGYGLRLQDYDANSLPELLAKL-CHVVKVVDGAEGREVQL INRKSLRALTSQLLTLLMG----------------PAPGSAPPPQRQGKGDGAGGQE--- ----------PAWPDVEQLQQRYEAAHSAPLKPCEYGFLSLSELLKSLPFLVE------- ---LYEVEEG-D---------------------------------GECGG--RERVRLTR LYQFACRVRALLHTYHYHQIFLSEFPSAFSKYTGLSLQCRTYGYGTLDELLAAIPQVIWI KGHGHKKIIVLKNEMK----------------VRNS------------------------ ------------------------------------------------------------ ------------------------------------SAP--GDSPGPEGDRVRADSQSSS SAKSGNQS-----------------------------------P---------------- --------------------------------------------------------G--- ------CDP------------------------ELLCLGSGSPVDLLCGPVPSCLPSPQL HPDPVPLQ-PADLIHFEE------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------KDHNDLQTEAASSEEVPWSSASAPSACD DSSSQDGANSDTSITTTLAATAAAALEPQSPLLA---------APVTDSPSKRTPRTRVK LAANFSFTPA-----------------------------------------TTA >ENSDCDP00000052507 -----------------------------------------------------MEGCGAG PGAGPGPGPGSAPRL--------------------------------------------- -WKLSD---------CFSS---------------------T----PDNK----------- ------------------K-DYMDGQTPVLELKDVP--PP-PR----HSVPQ-------- RF-PLAPL----PM--PPP---------------------------PCL----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------L---------------------------------- ------------------------------------------------------------ P----------------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------PP ------P----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -LPLHVDGPNVSACACCRLGAEHFGSRSHKSGDGGVSTLYTAEAPLASASSCSHPLRASP FSGHRNLQVATSQPPASHSHLPCCMGPI-------------RPLH--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PAPYPRSPHVGHPTLGALHPAPATSSSSSSSSSSGCSYCVRHSEAGTPPHLH-PFHL GAEH-RVCLKGAHYCQDCFRK--------------------------------------- ---PSDAL-VAE----PEKRCPGVPPPLAQSAPI--PVPMCNGCGASGAVSDG---ML-G NSLGKPSLKYG------SPDVGAQESLPPVGVFWDIENCSVPSGRSAASVVQRLRTHFFQ GHREAEFICVCDINKENKAVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFAETHTAP ATVVLVSSDVNFASELSDLRHRHGFLVILVH-KNQVSGALLQHAHHHVAFEEFLTDLPPR MPVK-------SQPGFNLLFVRNLPTHRD------------AKSVSNRLRRLSDNCGGRV LG--ISGGTAVLRFGSLEAAERARKRMDHEDVFGCRIRVSFS------------------ ---------P------------------------------------DSL----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------KDEEAVGEPEE- ------------------------------------------------------------ --AA--------FLP-------------------------AEK---PRSPRRPRRAGALP PAR------LCQ-------AGRD---TVPERPYSPRKGVQ-------------------- -------------------PAAAAPGH-------------------------------LQ ELGMEPKCKMAFMVEKSHPPAEMDTAHQFKA----------------------------- ----------------------------RRRDSSGP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------RSGTDLPVE--------------------- ----------------------------------------------------------HF QVSTPSAFSKLCLQRSFSPML------ISQGSW-SS--RSGSPSLSNHSSPLNAPS---- -YSPC-PD------------SSE-PFSDGADIQVANIDYRMSRKELQQILLDTFSKHGRV KSVELSPHTDYQLKATVQMASLQQAIGAVSCLHRFKIGAKRIRVSLVTGAINKSLTILST EIVSILQDAPANCLPLFKFTEIYEKKFGHKLVASELYRLPEVVSVREQGGGRLVCLLPSS QARQSPLGSS--QSHDS-SSTSGSPVVFEELEYHEPVCKRHHGQQNFSEADYDPDSYKVP FVVVSLKTLAAQVHGLLQTHEGTVPLLSFLECYAAEFSPLEVGEEGELPGGVPLEHLITC VPGITVVTAQNGFKVIKWIHNKPPPPN-AD------PWVQRCKSPVGNPQLIQFSREMVD LLKNQPACLMPLSKFIPAYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGLGSKRLLT LTHRAQVKRFTQDLLKLLKFQASKQVVIQDFMQAYHWCFSRDWQVVSYGMCDLMDLLSEI PDTTITITHQDEDMVISVPKR-ER-TPQEVERTKQFAKEVVDLLRHQAHFRMPFSKFIPT YHHHFGRQCKLTCYGFTKLVELFEAIPDVLMVLECGEEKVLSLTEVERVKALAAQMVKLL HAQKDASLPMQHLLSEYSKTFGYGLRLQDFDVSSLPALLSKL-CHVVKVVDCAEDPNVQL INRKSLRALTSQLLVLLMGQGDARDWLSLEELSGL------------------------- ----------------------YEASHGVPLNPCEYGFLSLTELLKSLPYLVE------- ---LFEGENE-E---------------------------------GCC----EERARLTR LYQFARSVRALLHTYHYNQIFLTEFPAAFSKYTGRRVQPRTYGYATLDELLTAVPQVVWI KGHGHKKIIVLKNDMK----------------ARSSP----------------------- -----ATVLS------PD-----P--------------------------E--------- -----GNLR--------------------------ESSP--------------------N SAKSGDQS-----------------------------------S---------------- --------------------------------------------------------G--- ------TEA------------------------ELLCLSSSSPVDLLCAPVPSWLPSPQL HPDPILLQ-HTDLIRFEE------------------------------------------ --------------------------------QFP------------------------- ------------------------PSTRT------------------------------- ---------------------------ETPSPTPAPV----------------APDVCS- ------------------------------------------------------------ ------------------------------------------------------------ -SAVLSQEATPTQPFTTAATMVARPGP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PHAS---------------------------- -----------------------------------------------DCPTKRTPRNRVR LAANFSLSQM-----------------------------------------PTA