>ENSJJAP00000014847 ------------------------------------------------------------ ------------------------------------------------------------ -------NDRHREKDRERERERERERENGRARAFSLYVL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EDE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------RLKQIKKCLPSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSHLEGPAGGPAKNKVA-KVSVKSGSHKVMQDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------E-------------- ------G---------------------------------------DDF----------- -------------------RDFTGNIRKGKHPKREVTV---------------------- -------------------------DKGS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----DK----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------ESED-EWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP------------VLGD----SAS---- ---------C-PSVLPVKP----VEIEIETPEQAKTRERS-------------EKIKMEF ETYIRRMMKRFNKEVQENTHKVHLLCLLANGFYRSSICSQPDLLAIGLSIIPTHFT---- --KVPPQDVDIHYLCDLVKW----------FIGTFTVNADLSSSEQD-----SLQTTLER RFAIYSARDEEELVH--------------------------------------------- ---------------------------------IFLLILRSLQLLTRLVVSLQPIPLKLS V--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERSIDGPG---ASSEPSCHILKSHDK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK RTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFC---------------------KGNSKTSAKWKRSK------------------- ------------------------------------------------------------ STARDKEPRRL----------SSSEED--------------------------------- ------------------------------------------------------------ -----------------------------------------------------GEQPEET ------------------------------------------------------------ ---------QR-------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DA AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--AHHSS-EDSE-------------------------PGPARQKRVVAPQR TKT--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKRNSR TQHGSYCKLSEFPAV-------SSSLSTS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----SK--------------------------------- -----------------------------------KISSGG------------------- ------------------PE---------------------------------------- ------------------------------------------------------------ ---------E------EDRK---------------------------------------- ------------------------------------------------------------ -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GADQWLEVFCEPEEKWVCVDCVH-GVVNQPVVCYRYATKPVTYV VGIDSDGWVRDVTQRYDPAWMTATRKCRVDAEWWTKTLRPYQSPFMKREKKEDLEF-QEK HLDQPLPTAIGTYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRLGEVPYKMVKGYSNRARKARLAEPQLQDQNDLGLFGHWQTEEYQPPVA VGGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFKDVLLAAWENEQALIEKK EKEKKEKRALGNWKLLVKGLLIRERLKLRY----------GTGAEAEAPH---------- ---------------------------TA------VGDGLSSD--E------EGT----- ------------SSKA-EAARILAASWPQNRE--------------------A----EE- ------QKPK-CPR---KTRRG-------------------------------------- ------------------------------------------------------------ --------------------------------------------TVAASHLFPFEK-L >ENSMUSP00000032182 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------PKRTADGRRRKR------------------------------------ -----------------------------------------GQKTEDNKVARH------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EESVA--------------------- -------------------DDF-------------------------------------- -------------EDEKQKP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------R------- ----------------------------------RKSSFPKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGDPTNGAAKKKVA-KATAKSKNLKVLKEEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SPADCKKAKKHPKSKVV------------------------------------------- -----------------------------------DQG---------------------- -----TD----------------------------------------------------- ------------------------------------------------------------ -E----D--------------DSED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP------------VL-DMGENSAT---- ---------S-PSDMPVKA----VEIEIETPQQAKERERS-------------EKIKMEF ETYLRRMMKRFNKEVQENMHKVHLLCLLASGFYRNSICRQPDLLAIGLSIIPIRFT---- --KVPLQDRDAYYLSNLVKW----------FIGTFTVNADLSASEQD-----DLQTTLER RIAIYSARDNEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA V--------------------------------------TK------------------- ------------------------------------------------GR-KS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ETSVEGPG---GSSELSSNSPESHNK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PTTSR RIKEEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TLS---------------------EGRGKATARGKRGT------------------- ------------------------------------------------------------ -------------------------------------GTAGSRQ---------------- -----------------------RRKPSCS------------------------------ -------------------EGEEAEQ------KVQGRPH--------------A------ -----------------------------------------------------------R K-----------------------------------------RRVAAKVSYKEESES--- ----------------------------------------------------------DG AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----PSSGE--GQHSSDEDCE-------------------------PGPRKQKRASAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASK TQRGSQCEPSSFPEA-------SSSSSGC------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KVSSGA------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------M------ADRK---------------------------------------- ---------------------------------P-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVYCEPQAKWVCVDCVH-GVVGQPVACYKYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPYRSLLTEREKKEDQEF-QAK HLDQPLPTSISTYKNHPLYALKRHLLKFQAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGFSNRARKARLSEPQLHDHNDLGLYGHWQTEEYQPPIA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQMTLPNLN RVARKLGIDCVQAIT-----GFDFHGGYCHPVTDGYIVCEEFRDVLLAAWENEQAIIEKK EKEKKEKRALGNWKLLVRGLLIRERLKLRY----------GAKSEAAAPH---------- ---------------------------A-------AGGGLSSD-EE------EGT----- ------------SSQA-EAARVLAASWPQNRE--------------------D----PE- ------QKSE-YTK---MTRKR-------------------------------------- ------------------------------------------------------------ -------------------------------------------RAAEASHLFPFEK-L >MGP_SPRETEiJ_P0078084 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------PKRTADGRRRKR------------------------------------ -----------------------------------------GQKTEDNKVARH------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EESDA--------------------- -------------------DDF-------------------------------------- -------------EDEKQKT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------R------- ----------------------------------RKSSFPKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGDPTSGAAKKKVA-KATAKSKNLKVLKEEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SPADCKKAKKHPKIEVV------------------------------------------- -----------------------------------DQG---------------------- -----TD----------------------------------------------------- ------------------------------------------------------------ -E----D--------------DSED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP------------VL-DMGENSAT---- ---------S-PSDLPVKA----VEIDIETPQQAKERERS-------------EKIKMEF ETYLRRMMKRFNKEVQENMHKVHLLCLLASGFYRNSICRQPDLLAIGLSIIPIRFT---- --KVPLQDRDAYYLSNLVKW----------FIGTFTVNADLSASEQD-----DLQTTLER RIAIYSARDNEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA V--------------------------------------TK------------------- ------------------------------------------------GR-KS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ETSVEGPG---GSSELSSNSPESHNK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PTTSR RIKEEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TLS---------------------EGRGKATARGKRGT------------------- ------------------------------------------------------------ -------------------------------------GTAGSRQ---------------- -----------------------RRKPSCS------------------------------ -------------------EGEEAEQ------KVQGRPH--------------A------ -----------------------------------------------------------R K-----------------------------------------RRVAAKVSYKEESES--- ----------------------------------------------------------DG AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----PSSGE--GQHSSDEDCE-------------------------PGPRKQKRASAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASK TQRGSQCELSSFPEA-------SSSSSGC------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KVSSGA------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------M------ADRK---------------------------------------- ---------------------------------P-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVYCEPQAKWVCVDCVH-GVVGQPVACYKYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPYRSLLTEREKKEDQEF-QAK HLDQPLPTSISTYKNHPLYALKRHLLKFQAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGFSNRARKARLSEPQLHDHKDLGLYGHWQTEEYQPPIA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQMTLPNLN RVARKLGIDCVQAIT-----GFDFHGGYCHPVTDGYIVCEEFRDVLLAAWENEQAIIEKK EKEKKEKRALGNWKLLVRGLLIRERLKLRY----------GAKSEAAAPH---------- ---------------------------A-------AGGGLSSD-EE------EGT----- ------------SSQA-EAARVLAASWPQNRE--------------------D----PE- ------QKSE-YTK---MTRKR-------------------------------------- ------------------------------------------------------------ -------------------------------------------RAAEASHLFPFEK-L >MGP_PahariEiJ_P0051228 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------PKRTADRRRRKR------------------------------------ -----------------------------------------SQEAEDNKVARH------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EESDA--------------------- -------------------DDF-------------------------------------- -------------EDEKQKP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------RKRFLPKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGDPTNGAAKKKVA-KATAKSKNLKARKEEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDS----------- -------------------RD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SPADCKKAKKHPTREVV------------------------------------------- -----------------------------------DQG---------------------- -----SD----------------------------------------------------- ------------------------------------------------------------ -E----D--------------DSED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP------------VL-DMGENSAT---- ---------S-RSDPPVKA----VEIEIETPQQAKERERS-------------EKIKMEF ETYLRRMMKRFNKEVKENMHKVHLLCLLASGIYRNSICRQPDLLAIGLSIIPIRFT---- --KVPLQDRDVSYLSNLVKW----------FIGTFTVNADLSASEQD-----SLQTTLER RIAIYSARDNEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA M--------------------------------------TK------------------- ------------------------------------------------GR-KS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ETSGEGPG---GSSELSSNSPESHSK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PTTSR RIKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TLS---------------------EGRGKATTKGKRGT------------------- ------------------------------------------------------------ -------------------------------------GTAGSRQ---------------- ----------------------RRRKPSCS------------------------------ -------------------EGEEAKQ------EVQGRPH--------------A------ -----------------------------------------------------------R K-----------------------------------------RRVAVKVSYKEESES--- ----------------------------------------------------------DG AG-----------------------------SS------------------SD------- --------------------------------------------------------FE-- ----LSSGE--GQHSSDEDCE-------------------------PGPRKQKRASASQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASK TQLRGQCEPPSFPEA-------SSSSSGC------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KVSSGA------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------M------EDRR---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVYCEPQAKWVCVDCVH-GVVGQPVACYKYATKPMTYV VGIDSDGWVRDVTQRYDPAWLTTTRKCRVDAEWWAETLRPYRSPLTEREKKEDQEF-QAK HLDQPLPTSISTYKNHPLYALKRHLLKFQAIYPETAAVLGYCRGEEVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGFSNRARKARLSEPQLHDHNDLGLYGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQMTLPNLH RVARKLGIDCVQAIT-----GFDFHGGYCHPVTDGYVVCEEFRDVLLAAWENEQAIIEKK EKEKKEKRALGNWKLLVRGLLIRERLKLRY----------GAKSEAAAPH---------- ---------------------------A-------AGGGLSSD-EE------EGT----- ------------SSQA-EAARVLAASWPQNRE--------------------A----TE- ------PKPE-YTK---MTRKR-------------------------------------- ------------------------------------------------------------ -------------------------------------------RAAEASHLFPFEK-L >ENSRNOP00000011490 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRTAGGKRRKR------------------------------------ -----------------------------------------GQEAEDNKATRP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EESDA--------------------- -------------------DDF-------------------------------------- -------------EDEKQKP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------RKCFLPKVSQGKR-KR---------- ------------------------------------------------------------ -----------DCSDPGDPTNGAAKKKVA-KATTKSKNLKAVKEEAL------------- ----------------------------------------------SD------------ ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SLSNCRKAKKHPKREVV------------------------------------------- -----------------------------------DQG---------------------- -----TD----------------------------------------------------- ------------------------------------------------------------ -E----D--------------DSED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP------------VL-DMGENSAT---- ---------S-RSDLPVKA----VEIEIETPEQAKARERS-------------EKIKMEF ETYLRRMMKRFNKEVQENMHKVHLLCLLASGFYRNSICQQPDLLAIGLSIIPIRFT---- --KVPLQDRDVYYLSNLVKW----------FIGTFTVNADLSASEQD-----SLQTTLER RIAIYSARDNEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA V--------------------------------------AK------------------- ------------------------------------------------GK-KS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ETSLEGPG---DSSEPSSNIPESHNK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK RIKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TLS---------------------EGSGKANARGKRGT------------------- ------------------------------------------------------------ -------------------------------------ATAGSRQ---------------- -----------------------QRKPSCS------------------------------ -------------------EGEEAKQ------EIQSHPQ--------------A------ -----------------------------------------------------------Q K-----------------------------------------RRVAAKVSYKEESES--- ----------------------------------------------------------DG AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--GQHSSDEDCK-------------------------PGPRKQKRASAPQR SKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASK TQSGSQWEPPSFSVA-------SSSSSAC------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KISCGG------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------T------DDRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEPQAKWVCVDCVH-GVVGQPVACYKYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPYRSPLTEREKKEDQEF-QAK HLDQPLPTSISTYKNHPLYALKRHLLKFQAIYPESAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGFSNRARKARLSEPQLHDHNDLGLFGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQMNLPNLH RVARKLGIDCVQAIT-----GFDFHGGYCHPVTDGYVVCEEFRDVLLAAWENEQALIEKK EKEKKEKRALGNWKLLVRGLLIRERLKLRY----------GAKSEAAAPH---------- ---------------------------AN------AGGGLSSD-EE------EGT----- ------------SSQA-EAARVLAASWPQNRE--------------------T--K-EE- ------QKPD-YTK---MTRRR-------------------------------------- ------------------------------------------------------------ -------------------------------------------RAAEASHLFPFEK-L >ENSCGRP00000022070 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------PKRPAGGRRRGR------------------------------------ -----------------------------------------GREAENNKAARP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EESEA--------------------- -------------------DDF-------------------------------------- -------------EDEKQKP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKCPLSKVSQRKR-KR---------- ------------------------------------------------------------ -----------ACSDPGDPTKGPSKKKVA-KATAKSENLKAPKEEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PPGDCKKSKKHPKREVV------------------------------------------- -----------------------------------DEG---------------------- -----SD----------------------------------------------------- ------------------------------------------------------------ -E----DE-------------DSED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP------------ML-DTGENPST---- ---------S-QSVLPVKA----VEIEIETPEQAKARKRS-------------EKIKMEL EMYLRRMMKRFNKEVQENMHKVHLLCLLASGFYRNSICRQPDLLAIGLSIIPTRFT---- --KVPLKDRDICFLSNLVKW----------FIGTFTVNEDLSASEQD-----SLQTTLER RIAIYSARDEEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSS V--------------------------------------TK------------------- ------------------------------------------------GK-KS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ETSLESPG---GSSEPSSQVLESHNR--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK RIKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TVS---------------------EDSDKANTRGKKSK------------------- ------------------------------------------------------------ -------------------------------------A-VDSRQ---------------- -----------------------RRKPSCS------------------------------ -------------------EGEETKP------KTQSRAH--------------A------ -----------------------------------------------------------R Q-----------------------------------------RRVAAKVSYKEESGS--- ----------------------------------------------------------DE DG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--GQHSSDEEHK-------------------------PSPRKQKRTPVPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------RSKSASK HQ------PPGFPVA-------SSSSSGS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KVSSGG------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------T------GDRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVNQWLEVFCEPQAKWVCVDCVH-GVVAQPLTCYKYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPYQSPLKEREKKEDQEF-QAK HLDQPLPTSISTYKNHPLYALKRHLLKFQAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGFSNRARKARLSEPQLHDYNDLALYGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQMNLPNLH RVARKLGIDCVQAIT-----GFDFHGGYCHPVTDGYIVCEEFKDVLQAAWENEQDIIEKK EKEKKEKRVLGNWKLLVRGLLIRERLQLRY----------GAKSEAVAPH---------- ---------------------------AN------AGGGLSSD-EE------EGT----- ------------SSQA-EAARVLAASWPQNRE--------------------A--K-EE- ------QKPE-YSK---MTRKR-------------------------------------- ------------------------------------------------------------ -------------------------------------------RAAEASHLFPFEK-L >ENSCGRP00001012909 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------PKRPAGGRRRGR------------------------------------ -----------------------------------------GREAENNKAARP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EESEA--------------------- -------------------DDF-------------------------------------- -------------EDEKQKP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKCPLSKVSQRKR-KR---------- ------------------------------------------------------------ -----------ACSDPGDPTKGPSKKKVA-KATAKSENLKAPKEEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PPGDCKKSKKHPKREVV------------------------------------------- -----------------------------------DEG---------------------- -----SD----------------------------------------------------- ------------------------------------------------------------ -E----DE-------------DSED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP------------ML-DTGENPST---- ---------S-QSVLPVKA----VEIEIETPEQAKARKRS-------------EKIKMEL EMYLRRMMKRFNKEVQENMHKVHLLCLLASGFYRNSICRQPDLLAIGLSIIPTRFT---- --KVPLKDRDICFLSNLVKW----------FIGTFTVNEDLSASEQD-----SLQTTLER RIAIYSARDEEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSS V--------------------------------------TK------------------- ------------------------------------------------GK-KS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ETSLESPG---GSSEPSSQVLESHNR--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK RIKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TVS---------------------EDSDKANTRGKKSK------------------- ------------------------------------------------------------ -------------------------------------A-VDSRQ---------------- -----------------------RRKPSCS------------------------------ -------------------EGEETKP------KTQSRAH--------------A------ -----------------------------------------------------------R Q-----------------------------------------RRVAAKVSYKEESGS--- ----------------------------------------------------------DE DG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--GQHSSDEEHK-------------------------PSPRKQKRTPVPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------RSKSASK HQ------PPGFPVA-------SSSSSGS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KVSSGG------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------T------GDRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVNQWLEVFCEPQAKWVCVDCVH-GVVAQPLTCYKYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPYQSPLKEREKKEDQEF-QAK HLDQPLPTSISTYKNHPLYALKRHLLKFQAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGFSNRARKARLSEPQLHDYNDLALYGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQMNLPNLH RVARKLGIDCVQAIT-----GFDFHGGYCHPVTDGYIVCEEFKDVLQAAWENEQDIIEKK EKEKKEKRVLGNWKLLVRGLLIRERLQLRY----------GAKSEAVAPH---------- ---------------------------AN------AGGGLSSD-EE------EGT----- ------------SSQA-EAARVLAASWPQNRE--------------------A--K-EE- ------QKPE-YSK---MTRKR-------------------------------------- ------------------------------------------------------------ -------------------------------------------RAAEASHLFPFEK-L >ENSCGRP00015018087 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---VHGALHLICVVFIVTIEKALGERLSTVCCLRHRMVTRGLMTDVVLGSLAQKSHCLHL LNHLSPLALCCY------------------------------------------------ --L--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DDF-------------------------------------- -------------EDEKQKP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKCPLSKVSQRKR-KR---------- ------------------------------------------------------------ -----------ACSDPGDPTKGPSKKKVA-KATAKSENLKAPKEEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PPGDCKKSKKHPKREVV------------------------------------------- -----------------------------------DEG---------------------- -----SD----------------------------------------------------- ------------------------------------------------------------ -E----DE-------------DSED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP------------ML-DTGENPST---- ---------S-QSVLPVKA----VEIEIETPEQAKARKRS-------------EKIKMEL EMYLRRMMKRFNKEVQENMHKVHLLCLLASGFYRNSICRQPDLLAIGLSIIPTRFT---- --KVPLKDRDICFLSNLVKW----------FIGTFTVNEDLSASEQD-----SLQTTLER RIAIYSARDEEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSS V--------------------------------------TK------------------- ------------------------------------------------GK-KS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ETSLESPG---GSSEPSSQVLESHNR--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK RIKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TVS---------------------EDSDKANTRGKKSK------------------- ------------------------------------------------------------ -------------------------------------A-VDSRQ---------------- -----------------------RRKPSCS------------------------------ -------------------EGEETKP------KTQSRAH--------------A------ -----------------------------------------------------------R Q-----------------------------------------RRVAAKVSYKEESGS--- ----------------------------------------------------------DE DG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--GQHSSDEEHK-------------------------PSPRKQKRTPVPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------RSKSASK HQ------PPGFPVA-------SSSSSGS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KVSSGG------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------T------GDRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVNQWLEVFCEPQAKWVCVDCVH-GVVAQPLTCYKYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPYQSPLKEREKKEDQEF-QAK HLDQPLPTSISTYKNHPLYALKRHLLKFQAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGFSNRARKARLSEPQLHDYNDLALYGHWQTEEYQPPVA VDGKVRTALGGQSRLPCFPSSYILACPSLQVPRNEFGNVYLFLPSMMPIGCVQMNLPNLH RVARKLGIDCVQAIT-----GFDFHGGYCHPVTDGYIVCEEFKDVLQAAWENEQDIIEKK EKEKKEKRVLGNWKLLVRGLLIRERLQLRY----------GAKSEAVAPH---------- ---------------------------AN------AGGGLSSD-EE------EGT----- ------------SSQA-EAARVLAASWPQNRE--------------------A--K-EE- ------QKPE-YSK---MTRKR-------------------------------------- ------------------------------------------------------------ -------------------------------------------RAAEASHLFPFEK-L >ENSPEMP00000016162 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKHPAGRRRRGR------------------------------------ -----------------------------------------GPEAKDNKAARP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EESEA--------------------- -------------------DDF-------------------------------------- -------------EDENQKP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKCFPSRVSRGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGDPTDGAAKTKVA-KATAKSKNLKAPKEEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SPGDCKKAKKHAKTEVV------------------------------------------- -----------------------------------DGG---------------------- -----SD----------------------------------------------------- ------------------------------------------------------------ -E----DE-------------DSED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP------------ML-DMGEDSAT---- ---------S-QSVLPVKA----VEIEIETPEQAKARKRS-------------EKIKMEL ETYLRRMMKRFNKEVQENMHKVHLLCLLASGFYRNSICRQPDLLAIGLSIIPTRFT---- --KVPLQNRDICFLSNLVKW----------FIGTFTINADLSASEQD-----SLQTTLER RIAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPVPLKSS V--------------------------------------TK------------------- ------------------------------------------------GT-KS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ST------------------------- ------------------------------------------------------------ -------------GTSLESPG---GSSDPSSNVPESPKR--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK RIKEEEASSEC------------------------SEKADA------------------- ---------------RGK------------------------------------------ RRSK-----------------------------------------------------ATA GSG--------------------------------------------------------- ------------------------------------------------------------ -------------------------------------------Q---------------- -----------------------RRKPSCS------------------------------ -------------------EGEEAKP------KTQSRAR--------------A------ -----------------------------------------------------------R QR--------------------------------------RRRRVAAKVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--GRNSSDEDCE-------------------------PGPRKQKRTPGPQR TKT--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------RSKSATK TQ----CEPPSFPAA-------SSSSSGS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GR--------------------------------- -----------------------------------KVSSGG------------------- ------------------QV---------------------------------------- ------------------------------------------------------------ ---------T------GERK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GIDQWLEVFCESQAKWVCVDFVH-GVVGQPLTCYKYATKPMTYV VGIDNDGWVRDVTQRYDPAWMTTTRKCRVDSEWWAETLRPYQSPLTEREKKEDQEF-QAK HLDEPLPTSIGTYKNHPLYALKRHLLKFQAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGFSNRARKARLSEPQLHDYNDLALYGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQMHLPNLH RVARKLGIDCVQAIT-----GFDFHGGYCHPVTDGYIVCEEFRDVLLTAWENEQAIIEQK EKEKKEKRALGNWKLLARGLLIRERLQLRY----------GPKSEAGAPH---------- ---------------------------AN------AGGGLSSD-EE------EGT----- ------------SSQA-ETARVLAASWPQNRE--------------------A--K-EE- ------QKPE-YPK---MTRKR-------------------------------------- ------------------------------------------------------------ -------------------------------------------RAAEASHLFPFEK-L >ENSMOCP00000003687 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRRAGGRRRGR------------------------------------ -----------------------------------------GREAEDNKAARH------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EESEA--------------------- -------------------DDF-------------------------------------- -------------EDEKQKP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKCLVSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGDPGKGPAKKKAT-KATAKSKNLKAPKEEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------GE------------------------------------DRDDF----------- -------------------RE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SPGDRKKAKKHPKREVV------------------------------------------- -----------------------------------DKD---------------------- -----SD----------------------------------------------------- ------------------------------------------------------------ -E----DE-------------DSED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP------------VL-DMGENSAT---- ---------S-QSVLPVKA----VEIEIETPEQAKARKKS-------------EKIKMEL ETYLRRMLKRFNKEVQENMHKVHLLCLLASGFYRNNICREPDLLAIGLSIIPTRFT---- --KVPLQHRDTTFLSNLVKW----------FIGTFTVNADLSASEQD-----SLQTTLER RIAIYSARDEEELVY--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKPS V--------------------------------------AK------------------- ------------------------------------------------GK-KL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ST------------------------- ------------------------------------------------------------ -------------ETSLESPG---GSSETSSKVPESHNT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK RIKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFS---------------------EDSDRADAGGKRSK------------------- ------------------------------------------------------------ -------------------------------------ATVGSRQ---------------- -----------------------RRKPSCS------------------------------ -------------------EGEEAKQ------KTQRRAH--------------T------ -----------------------------------------------------------R A-----------------------------------------RRVTAKVSYK-ESGS--- ----------------------------------------------------------ED AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--GQHSSDEDGE-------------------------PYPRKQKRAPVSQR SNA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------RSKSASK TQ----HGPPDFPAA-------SSSSSGS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KVSSGG------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------I------RDGK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEPQAKWVCVDCVH-GVVGQPLTCYRYATKPTTYV VGIDSDGWVRDVTQRYDPAWMTATRKCRVDAEWWTETLRPYQSPLTEREKKEDQEF-QAK HLDEPLPTSIGIYKNHPLYALKRHLLKFQAIYPETAAVLGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRLGEVPYKMVKGFSNRARKARLSEPQLHDYNDLALYGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQMHLPNLH RVARKLGIDCVQAIT-----GFDFHGGYCHPVTDGYVVCEEFRDVLLTAWENEQAIIEKK EKEKKEKRALGNWKLLVRGLLIRERLQLRY----------GAKSEAVVPH---------- ---------------------------GN------AGGGLSSD-EE------EGT----- ------------SSQA-ETARVLAASWPQNRE--------------------A--K-EE- ------PKPE-YRK---MTRKR-------------------------------------- ------------------------------------------------------------ -------------------------------------------RAAEASHLFPFEK-L >ENSMUGP00000018769 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRTAGGRRRRR------------------------------------ -----------------------------------------GREVEDNKAARQ------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EESET--------------------- -------------------DDF-------------------------------------- -------------EDEKQKP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKDFLSKVSQGKRKKR---------- ------------------------------------------------------------ -----------GFSDPGDATNGSAKKKVA-RATAKSERPKALKEEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ SPGDCKKVKKHPKKEVV------------------------------------------- -----------------------------------DKS---------------------- -----SD----------------------------------------------------- ------------------------------------------------------------ -E----DQ-------------DSED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP------------VL-DMGENSAT---- ---------S-LSALPEKA----VEIEIETPEQAKARKRS-------------EKIKMEL ETYVRRMIKRFNKEVQENMHKVHLLCLLASGFYRNNICRQPDLLAIGLSIIPAHFT---- --KVPLQNRDVSYLSKLVKW----------FIGTFTVNTDLSASKQD-----SLQTTLER RIAIYSARDNEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPISLKSS V--------------------------------------TK------------------- ------------------------------------------------GK-KS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PE------------------------- ------------------------------------------------------------ -------------ETSLEGPG---GSSKPSSKVSKSHNK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PTTSK RIKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFS---------------------EGNGKADARGERRK------------------- ------------------------------------------------------------ -------------------------------------AAVGNRQ---------------- -----------------------QRKPSCS------------------------------ -------------------EGEEAKR------KIQSCSH--------------TQ----- ----------------------------------------------------------KR K-----------------------------------------RRVAAKVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--GQHSSDEDSE-------------------------PGRRRRKRALAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASK TQCRSQREQPSFSAA-------SSGSLGS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KVSSGG------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------T------EDRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------S---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEPQAKWVCVDCVH-GVVGQSVICYKYATKPMTYV VGIDSDGWARDVTQRYDPFWMTATRKFRVNAEWWAETLRPYQSPLTEREKKEDLEF-QAK HLEKSLPTSIGTYKDHPLYALKRHLLKFQAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLRQARVVRLGEVPYKMVKGFSNRARRARLSDPQMNDHNDLALYGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQMNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYCHPVTDGYIVCEEFKDVLLTAWENEQALIEKK EKEKKEKRALGNWKLLVRGLLIRERLRLRY----------GAKSEAVPSH---------- ---------------------------AN------AGGGLSSD-EE------EGT----- ------------SSQA-EAARVLAASWPQNRE--------------------V--K-QE- ------QKPE-YPK---RTRRR-------------------------------------- ------------------------------------------------------------ -------------------------------------------RAAEASHLFPFEK-L >ENSNGAP00000024440 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------V-------------------------------------------------- ------------RKRAAGRRRRGRKP---------------------------------- ----------------------------------------KGQDAEDQSAARP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------AESEA--------------------- -------------------DDF-------------------------------------- -------------EDEKPKS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKCFLSKVSKAKR-KR---------- ------------------------------------------------------------ -----------GCSDPGAPADGPVKKKVA-KATVKA--------ETL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------GED------------VRDF-------------AGHIKKV--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KHPEREVM------------------------------------------- -----------------------------------DKD---------------------- -----SD----------------------------------------------------- ------------------------------------------------------------ -E----DE-------------EESDGDWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TDP------------VL-DMGENSTS---- ---------S-QSVLPVKP----VEIEIETPEQAKTRKRR-------------EKIKMEF ETYLRRMMKRFNKEVHENMHKVHLLCLLANGFYRNSICSQPDLLAIGLSIIPTCFT---- --KVPPQDRDIRYLSNLVKW----------FIGTFTVNVDLSTSEQD-----SLQTTLER RFAIYSARNDEEVVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSS S--------------------------------------TK------------------- ------------------------------------------------GR-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ETCKDGPR---DSSEPSRQVPESHNK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --SKISRTHQQEEPFSKGRGKASAGQKSKTAAYSRQWRGPSFSEEKELGQETRSRSRA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R V-----------------------------------------RRVATRVSYK-ESGS--- ----------------------------------------------------------DK AG-----------------------------SS------------------SD------- --------------------------------------------------------FE-- ----LSSEE--AHSSSDENSE-------------------------PGSSRQKRAPAPKR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------RSKGGSR THRGSHREPPGFP-A-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------N----------------------------------- --------------------R----CK--------------------------------- -----------------------------------KVSRGG------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------A------EDRR---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEPQAKWVCVDCVH-GVVDQPLACYKYATKPMTYV VGIDSNGWVRDVTQRYDPAWMTATRKCRVDADWWAKTLRLYQSPFTEREKKEDLEF-QAK HLDQPLPTAIGTYKNHPLYALKRHLLKFEAIYPETAAILGYCRGEPVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGFSNRARKARLAEPQLQDYNDLGLFGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFQPSMMPVGCVQMNLPNLH RVARKLGIDCVQAIT-----GFDFHGGYCHPVTEGYIVCEEFKDVLLAAWENEQALIEKK EKEKREKRALGNWKLLVKGLLIKERLKLRY----------GAKSEPVAPH---------- ---------------------------TG------AGGGLSSD-EE------EGT----- ------------SSQA-ETARVLASSWPQNRE--------------------A----EE- ------QQPK-CPK---KTRRR-------------------------------------- ------------------------------------------------------------ -------------------------------------------AAAAASHLFPFEK-E >ENSBIXP00000002734 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGRGPR------GQTAKGETKARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------KEEEA--------------------- -------------------DVF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- ----------------------------------KKSPPTKVSRGKR-KR---------- ------------------------------------------------------------ -----------GCGDAGGSADGPVRRKAA-KVSVKSEEPQVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EDF----------- -------------------RDLPSARRKGQPPEREAAA---------------------- -------------------------DKGSCEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------DSEE-DWEEVE---------------------------- ---------------------------------------------------EV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VPGDVGESGAF---- ---------S-ASALPVKP----VEIEIETPEQVKARERS-------------EKIKMEF ETYLRRMMKRFSKEVHEDTHKVHLLCLLANGFYRNSICNQPDLQAIGLSIIPTRFT---- --KVPPRDVDVSYLSNLVKW----------FIGTFTVNAELSTNEQD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLLLRALHLPTRLVLSLQPVPLKLS A--------------------------------------EK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------CK------------------------- ------------------------------------------------------------ -------------ERSTEAPG---GSSEAASHAPGKPS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------GGSGGEHASSGGAGGARA RGKGGKAAAGRRPRGESPSSGEDAGQARGQRRGTQRRAQ--------------A------ -----------------------------------------------------------R R-----------------------------------------RRVAAKVSYKEESGS--- ----------------------------------------------------------DA AS-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----PSSED--SCRPSDEDSE-------------------------PGLPRPRRAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSRSK SQQGS------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------RGLRPGFVEASASAAGSKRKGGKKPSGDGGKAG-------- ------------------------------RQGA-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFLEREEKWVCVDCVH-GVVGQPLTCYQYATKPVTYV VGIDGAGCVRDVTQRYDPAWLTATRKSRVDAAWWAETLRPYRSPLVDREQREDQEF-QAK HLDQPLPTVIGTYKNHPLYALKRHLLKYEAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARRARQAEPQLHDYNDLGLFGRWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLNIDCAQAVT-----GFDFHKGYCHPITDGYVVCEEYRDVLLTAWENEQALIEKK EKEKREKRALGNWKLLVKGLLIRERLKLRY----------GAQSEAAAPH---------- ---------------------------TD------VGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------A----E-- -------KPK-CPR---KTRRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKEAAAHLFPFEK-L >ENSBIXP00005044240 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGRGPR------GQTAKGETKARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------KEEEA--------------------- -------------------DVF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- ----------------------------------KKSPPTKVSRGKR-KR---------- ------------------------------------------------------------ -----------GCGDAGGSADGPVRRKAA-KVSVKSEEPQVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EDF----------- -------------------RDLPSARRKGQPPEREAAA---------------------- -------------------------DKGSCEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------DSEE-DWEEVE---------------------------- ---------------------------------------------------EV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VPGDVGESAAF---- ---------S-ASALPVKP----VEIEIETPEQVKARERS-------------EKIKMEF ETYLRRMMKRFSKEVHEDTHKVHLLCLLANGFYRNSICNQPDLQAIGLSIIPTRFT---- --KVPPRDVDVSYLSNLVKW----------FIGTFTVNAELSTNEQD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLLLRALHLPTRLVLSLQPVPLKLS A--------------------------------------EK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------CK------------------------- ------------------------------------------------------------ -------------ERSTEAPG---GSSEAASHAPGKPS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------GGSGGEHASSGGAGGARA RGKGAKAAAGRRPRGESPSSGEDAGQARGQRRGTQRRAQ--------------A------ -----------------------------------------------------------R R-----------------------------------------RRVAAKVSYKEESGS--- ----------------------------------------------------------DA AS-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----PSSED--SCRPSDEDSE-------------------------PGLPRPRRAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSRSK SQQGS------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------RGLRPGFVEASASAAGSKRKGGKKPSGDGGKAG-------- ------------------------------RQGA-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFLEREEKWVCVDCVH-GVVGQPLTCYQYATKPVTYV VGIDGAGCVRDVTQRYDPAWLTATRKSRVDAAWWAETLRPYRSPLVDREQREDQEF-QAK HLDQPLPTVIGTYKNHPLYALKRHLLKYEAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARRARQAEPQLHDYNDLGLFGRWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLNIDCAQAVT-----GFDFHKGYCHPITDGYVVCEEYRDVLLTAWENEQALIEKK EKEKREKRALGNWKLLVKGLLIRERLKLRY----------GAQSEAAAPH---------- ---------------------------TD------VGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------A----E-- -------KPK-CPR---KTRRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKEAAAHLFPFEK-L >ENSBBBP00000018198 X----------------------------------------------------------- ---------------XXXXXXXXXXXXXXXXXXXXXXXXXXXXX---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EEEA--------------------- -------------------DVF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- ----------------------------------KKSPPTKVSRGKR-KR---------- ------------------------------------------------------------ -----------GCGDAGGSADGPVRRKAA-KVSVKSEEPQVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EDF----------- -------------------RDLPSARRKGQPPEREAAA---------------------- -------------------------DKGSCEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------DSEE-DWEEVE---------------------------- ---------------------------------------------------EV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VPGDVGESAAF---- ---------S-ASALPVKP----VEIEIETPEQVKARERS-------------EKIKMEF ETYLRRMMKRFSKEVHEDTHKVHLLCLLANGFYRNSICNQPDLQAIGLSIIPTRFT---- --KVPPRDVDVSYLSNLVKW----------FIGTFTVNAELSTNEQD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLLLRALHLPTRLVLSLQPVPLKLS A--------------------------------------EK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------CK------------------------- ------------------------------------------------------------ -------------ERSTEAPG---GSSEAASHAPGKPS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------GGSGGEHASSGGAGGARA RGKGGKAAAGRRPRGESPSSGEDAGQARGQRRGTQRRAQ--------------A------ -----------------------------------------------------------R R-----------------------------------------RRVAAKVSYKEESGS--- ----------------------------------------------------------DA AS-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----PSSED--SCLPSDEDSE-------------------------PGLPRPRRAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSRSK SQHGS------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------RGLRPGFVEASASAAGSKPKGGKKPSGDGGKAG-------- ------------------------------RQGA-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFLEREEKWVCVDCVH-GVVGQPLTCYQYATKPVTYV VGIDGAGCVRDVTQRYDPAWLTATRKSRVDAAWWAETLRPYRSPLVDREQREDQEF-QAK HLDQPLPTVIGTYKNHPLYALKRHLLKYEAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARRARQAEPQLHDYNDLGLFGRWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLNIDCAQAVT-----GFDFHKGYCHPITDGYVVCKEYRDVLLTAWENEQALIEKK EKEKREKRALGNWKLLVKGLLIRERLKLRY----------GAQSEAAAPH---------- ---------------------------TD------VGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------A----E-- -------KPK-CPR---KTRRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKEAAAHLFPFEK-L >ENSBTAP00000058770 MLMGVWREVTREDFCDPAHEPAMSPLFLCPSSRVP------------------------- -----------CGHLY-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- ----------------------------------KKSPPTKVSRGKR-KR---------- ------------------------------------------------------------ -----------GCGDAGGSADGPVRRKAA-KVSVKSEEPQVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EDF----------- -------------------RDLPSARRKGQPPEREAAA---------------------- -------------------------DKGSCEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------DSEE-DWEEVE---------------------------- ---------------------------------------------------EV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VPGDVGESGAF---- ---------S-ASALPVKP----VEIEIETPEQVKARERS-------------EKIKMEF ETYLRRMMKRFSKEVHEDTHKVHLLCLLANGFYRNSICNQPDLQAIGLSIIPTRFT---- --KVPPRDVDVSYLSNLVKW----------FIGTFTVNAELSTNEQD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLLLRALHLPTRLVLSLQPVPLKLS A--------------------------------------EK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------CK------------------------- ------------------------------------------------------------ -------------ERSTEAPG---GSSEAASHAPGKPS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------GGSGGEHASSGGAGGARA RGKGGKAAAGRRPRGESPSSGEDAGQARGQRRGTQRRAQ--------------A------ -----------------------------------------------------------R R-----------------------------------------RRVAAKVSYKEESGS--- ----------------------------------------------------------DA AS-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----PSSED--SCRPSDEDSE-------------------------PGLPRPRRAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSRSK SQQGS------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------RGLRPGFVEASASAAGSKRKGGKKPSGDGGKAG-------- ------------------------------RQGA-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFLEREEKWVCVDCVH-GVVGQPLTCYQYATKPVTYV VGIDGAGCVRDVTQRYDPAWLTATRKSRVDAAWWAETLRPYRSPLVDREQREDQEF-QAK HLDQPLPTVIGTYKNHPLYALKRHLLKYEAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARRARQAEPQLHDYNDLGLFGRWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLNIDCAQAVT-----GFDFHKGYCHPITDGYVVCEEYRDVLLTAWENEQALIEKK EKEKREKRALGNWKLLVKGLLIRERLKLRY----------GAQSEAAAPH---------- ---------------------------TD------VGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------A----E-- -------KPK-CPR---KTRRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKEAAAHLFPFEK-L >ENSTTRP00000010617 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSVRSKVSRGKR-KR---------- ------------------------------------------------------------ -----------GFGDSGGPADGPARKKAA-KVTVKSENPPVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EDS----------- -------------------RDFPSALKKVHRPEKEAAA---------------------- -------------------------DKGGGEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------G----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------ESEE-DWEEVE---------------------------- ---------------------------------------------------EV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VPGDVGESAAF---- ---------S-TSALPVKP----VEIEIETPEQVKARERS-------------EKIKTEF ETYLRRMMKRFNKEVREDTHKVHLLCLLANGFYRNSICNQPDLRAIGLSIVPTRFT---- --KVPPQDVDVSYLSNLAKW----------FIGTFTVNADLSTNEQD-----GLQTTLER RFAIYSARDSEELVH--------------------------------------------- ---------------------------------IFLLILRALHLPTRLVLSLQPIPLKLS A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERSTEGPG---GSSETSSQVPGKPSK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PETSR GSRRED------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---MSS---------------------EGTG----------------------SAP---- ----------------------------DKAKGSKAAAT--------------------- ------------------------------------------------------------ --------------------RKKRREPSSSRKEEGKAGGQTE------------------ --------------------------------GTQRRSR--------------G------ -----------------------------------------------------------R E-----------------------------------------RQAAARVSYKEESGS--- ----------------------------------------------------------DK AS-----------------------------SS------------------SD------- --------------------------------------------------------FELS RTAI----------PSDEDSE-------------------------PGLPRQRRAAAPQR MKV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKRESR SQRGSDGQPPGFPEAS-----VSASSSKR------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GKR-------------------------------- -----------------------------------KMPVDG------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------A------DGRR---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFSEQEEKWVCVDCVH-GVVGQPLTCYQYATKPVTYI VGIDSDGCLRDVTQRYDPAWMTVTRKCRVDAAWWAETLRPYQSPLVEREQKEDQEF-QAR HLDQPLPTVIGMYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRLGEVPYKVVKGYSNRARRARLAEPQLQDYNDLGLFGKWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPGMMPVGCVQLNLPNLH RVARKLNIDCAQAVT-----GFDFHKGYSHPITDGYIICEEYKDVLLAAWENEQALIEKK EKEKREKRALGNWKLLVKGLLIRERLRLRY----------GAQSEEAAPH---------- ---------------------------AD------AGGGLSSD-EE------EGT----- ------------SSPA-EVARILAASWPQNRE--------------------V--E-E-- -------KRK-CPR---KSRRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------EKEAASHLFPFEK-L >ENSVVUP00000024703 MR---------------------------------------------------------- -------------------------------------------RKEKEIGYVSSASYSSY WSFGAGAE------------------------------LRGRRRGAQGRGVAVPRPPRPL GAGS-------------------------------------------------------- -----------YSASRGSVRHGRG---------------------------------ESC PGSM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------V-------------------------------------------------- ------------RKRAAGREPQGRGP-CGRKAKG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KSTA-------------------------------ARE AAAAAAAAAADISEDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- ----------------------------------KRSLLSKVSRAKR-KR---------- ------------------------------------------------------------ -----------GCSGPGGPAHSPAKMKVA-KVSVKSENPKIVKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EEF----------- -------------------RDFASVRKKAHPSQREAAV---------------------- -------------------------DKGSCEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------ESED-EWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GEP------------VPGDVGENAAF---- ---------S-KSVLPVKP----VEIEIETPQQAKARERS-------------ERIKVEF ETYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRSNICNQPDLLAIGLSIVPTRFT---- --RVPPQDVDAGYLSNLVKW----------FVGTFTVNADLSTNEQD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLPTRLVLSLQPLPLKLP T--------------------------------------AK------------------- ------------------------------------------------GK-KA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------TT------------------------- ------------------------------------------------------------ -------------ERSAEDPG---SSLETSSPVAEGQTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTRQED------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TSS---------------------KSRGSTSAKGKKGKAAAV--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GKRRREPSSSGEEERKAGGQEE------------------ --------------------------------ETQRRRY--------------G------ -----------------------------------------------------------R E-----------------------------------------RQVASRVSYKEESAS--- ----------------------------------------------------------DK GS-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--AHHSSDEDSE-------------------------PVLPRQRRAPGPQR TKV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSRTDSR TQSGRPSKHPGFPAAS-----TSSSSSKS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------Q----GK--------------------------------- -----------------------------------KISSDG------------------- ------------------EG---------------------------------------- ------------------------------------------------------------ ---------A------ERRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWVCVDCVH-GVVGQALACYKYATKPMTYV VGIDGDGSVRDVTQRYDPAWMTATRKCRVDAKWWAETLRPYQSLLVEREKKEDSEF-QAK HLGQPLPTVIGTYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARKARLAEPQLQDQNDLGLFGKWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHKGYSHPITDGYIVCEEYKDVLLAAWENEQALIEKR EKEKREKRALGNWKLLARGLLIRERLKLRY----------GDESGTGAPQ---------- ---------------------------AH------AGGGLSSD-EE------EGT----- ------------SSQA-EASRILAASWPQNRE--------------------A--E-EE- ------QKPK-CSK---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSCAFP00000006670 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGREPQGREP-CGRKAKG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KSTA-------------------------------ARE --AAVAAAAADISEDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- ----------------------------------KRSLLSKVSRAKR-KR---------- ------------------------------------------------------------ -----------GCSGPGGPAHSPAKMKVA-KVSVKSENPKIVKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EEF----------- -------------------RDFASVRKKAHPSQREAAV---------------------- -------------------------DKGSCEE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------ESED-EWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GEP------------VPGDVGENAAF---- ---------S-KSVLPVKP----VEIEIETPQQAKARERS-------------ERIKVEF ETYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRSNICNQPDLLAIGLSIVPTRFT---- --RVPPQDVDSGYLSNLVKW----------FVGTFTVNADLSTNEQD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLPTRLVLSLQPLPLKLP T--------------------------------------AK------------------- ------------------------------------------------GK-KA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------TT------------------------- ------------------------------------------------------------ -------------EKSAEDPG---SSLETSSPVAEGQTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTRQED------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TSS---------------------KGLGSTSAKGKKGKAAAV--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GKRRREPSSSGEEERKAGGQEE------------------ --------------------------------ETQRRRY--------------G------ -----------------------------------------------------------R E-----------------------------------------RQVASRVSYKEESAS--- ----------------------------------------------------------DK GS-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--AHHSSDEDSE-------------------------PVLPRQRRAPGPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSRTDSR TQSGRPSKHPGFPAAS-----TSSSSSKS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------Q----GK--------------------------------- -----------------------------------KISSDG------------------- ------------------EG---------------------------------------- ------------------------------------------------------------ ---------A------ERRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWVCVDCVH-GVVGQALACYKYATKPMTYV VGIDGDGSVRDVTQRYDPAWMTATRKCRVDAKWWAETLRPYQSLLVEREKKEDSEF-QAK HLGQPLPTVIGTYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARKARLAEPQLQDQNDLGLFGKWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHKGYSHPITDGYIVCEEYKDVLLAAWENEQALIEKR EKEKREKRALGNWKLLARGLLIRERLKLRY----------GDESGTRAPQ---------- ---------------------------AH------AGGGLSSD-EE------EGT----- ------------SSQA-EASRILAASWPQNRE--------------------A--E-EE- ------QKPK-CSK---KTRRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSCAFP00020006987 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGREPQGREP-CGRKAKG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KSTA-------------------------------ARE --AAV-AAAADISEDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- ----------------------------------KRSLLSKVSRAKR-KR---------- ------------------------------------------------------------ -----------GCSGPGGPAHSPAKMKVA-KVSVKSENPKIVKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EEF----------- -------------------RDFASVRKKAHPSQREAAV---------------------- -------------------------DKGSCEE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------ESED-EWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GEP------------VPGDVGENAAF---- ---------S-KSVLPVKP----VEIEIETPQQAKARERS-------------ERIKVEF ETYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRSNICNQPDLLAIGLSIVPTRFT---- --RVPPQDVDSGYLSNLVKW----------FVGTFTVNADLSTNEQD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLPTRLVLSLQPLPLKLP T--------------------------------------AK------------------- ------------------------------------------------GK-KA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------TT------------------------- ------------------------------------------------------------ -------------EKSAEDPG---SSLETSSPVAEGQTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTRQED------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TSS---------------------KGLGSTSAKGKKGKAAAV--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GKRRREPSSSGEEERKAGGQEE------------------ --------------------------------ETQRRRY--------------G------ -----------------------------------------------------------R E-----------------------------------------RQVASRVSYKEESAS--- ----------------------------------------------------------DK GS-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--AHHSSDEDSE-------------------------PVLPRQRRAPGPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSRTDSR TQSGRPSKHPGFPAAS-----TSSSSSKS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------Q----GK--------------------------------- -----------------------------------KISSDG------------------- ------------------EG---------------------------------------- ------------------------------------------------------------ ---------A------ERRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWVCVDCVH-GVVGQALACYKYATKPMTYV VGIDGDGSVRDVTQRYDPAWMTATRKCRVDAKWWAETLRPYQSLLVEREKKEDSEF-QAK HLGQPLPTVIGTYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARKARLAEPQLQDQNDLGLFGKWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHKGYSHPITDGYIVCEEYKDVLLAAWENEQALIEKR EKEKREKRALGNWKLLARGLLIRERLKLRY----------GDESGTRAPQ---------- ---------------------------AH------AGGGLSSD-EE------EGT----- ------------SSQA-EASRILAASWPQNRE--------------------A--E-EE- ------QKPK-CSK---KTRRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSUMAP00000021728 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------V-------------------------------------------------- ------------RKRAARREPQGGEP-CGRKAKGESVAGR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EEKEA--------------------- -------------------DVL-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- ----------------------------------KRSLPSKVSRCKR-KR---------- ------------------------------------------------------------ -----------GRGDPGGPAQVPAKKKAA-QVTVKSENPKVVKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EEF----------- -------------------RDFAKGRKKAQPPRREAPA---------------------- -------------------------DKGSCEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GEP------------VPGDVGEDAAF---- ---------S-KSVLPVKP----VEIEIETPQQAKARERS-------------ERIKVEF ETYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRSHTCSQPDLLAVGLSIIPARFT---- --RVPPHDVDAGYLSNLVKW----------FIGTFTVNADLSTNEGD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLPTRLVLSLQPLPLKLP T--------------------------------------AK------------------- ------------------------------------------------GK-KA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PK------------------------- ------------------------------------------------------------ -------------ETSAESPG---GSLETRSPVPESQTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PETSK GTRQED------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TSS---------------------KGPGGPSAKGKRSKAAVV--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GKKRREPSCSGEEEHKAGGQQE------------------ --------------------------------DTWRRRH--------------G------ -----------------------------------------------------------R E-----------------------------------------RQVASKVSYKEESGS--- ----------------------------------------------------------DK VS-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--AHHSSDEDSE-------------------------PGLSRQRRAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKNDSR TQRGRHSKHPSFPAAS-----TSSSSNKS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KISSDG------------------- ------------------EG---------------------------------------- ------------------------------------------------------------ ---------A------ERGK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWVCVDCVH-GVVGQALTCYKYATKPMTYV VGIDGDGWVRDVTQRYDPAWMTVTRKCRVDAKWWAETLRPYQSPLVEREKKEDSEF-QAK HLGQPLPTVIGTYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARKARLAEPQLQDHNDLGLFGEWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHKGYSHPITDGYIVCEEYKDVLLAAWENEQALIEKR EKEKREKRALGNWKLLVRGLLIRERLKLRY----------GDKSEAGAPP---------- ---------------------------AP------A---FFSD-EE------EGT----- ------------SSQA-EASRILAASWPQNRE--------------------A--E-EE- ------QKPK-CPK---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFER-L >ENSUAMP00000021921 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------V-------------------------------------------------- ------------RKRAARREPQGGEP-CGRKAKGESVAGR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EEKEA--------------------- -------------------DVL-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- ----------------------------------KRSLPSKVSRCKR-KR---------- ------------------------------------------------------------ -----------GRGDPGGPAQVPAKKKAA-QVTVKSENPKVVKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EEF----------- -------------------RDFAKGRKKAQPPRREAPA---------------------- -------------------------DKGSCEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GEP------------VPGDVGEDAAF---- ---------S-KSVLPVKP----VEIEIETPQQAKARERS-------------ERIKVEF ETYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRSHTCSQPDLLAVGLSIIPARFT---- --RVPPHNVDAGYLSNLVKW----------FIGTFTVNADLSTNEGD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLPTRLVLSLQPLPLKLP T--------------------------------------AK------------------- ------------------------------------------------GK-KA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PK------------------------- ------------------------------------------------------------ -------------ETSAESPG---GSLETRSPVPESQTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PETSK GTRQED------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TSS---------------------KGPGGPSAKGKRSKAAAV--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GKKRREPSCSGEEEHKAGGQQE------------------ --------------------------------DTWRRRH--------------G------ -----------------------------------------------------------R E-----------------------------------------RQVASKVSYKEESGS--- ----------------------------------------------------------DK VS-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--AHHSSDEDSE-------------------------PGLSRQRRAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKNDSR TQRGRHSKHPSFPAAS-----TSSSSNKS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KISSDG------------------- ------------------EG---------------------------------------- ------------------------------------------------------------ ---------A------ERGK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWVCVDCVH-GVVGQALTCYKYATKPMTYV VGIDGDGWVRDVTQRYDPAWMTVTRKCRVDAKWWAETLRPYQSPLVEREKKEDSEF-QAK HLGQPLPTVIGTYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARKARLAEPQLQDHNDLGLFGEWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHKGYSHPITDGYIVCEEYKDVLLAAWENEQALIEKR EKEKREKRALGNWKLLVRGLLIRERLKLRY----------GDKSEAGAPP---------- ---------------------------AP------AGGGLSSD-EE------EGT----- ------------SSQA-EASRILAASWPQNRE--------------------A--E-EE- ------QKPK-CPK---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFER-L >ENSAMEP00000009896 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------V-------------------------------------------------- ------------RKRAARREPQGGEP-CGRKAKGESVAGR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EEKEA--------------------- -------------------DVL-------------------------------------- -------------EDE--KA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- ----------------------------------KRSLPSKVSRGKR-KR---------- ------------------------------------------------------------ -----------GCGDPGGTAQVPVKKKAA-QVTVKSENPKVVKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EEF----------- -------------------RDFAKGRKKAHPPRREAPV---------------------- -------------------------DKGSCEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GEP------------VPGDVGEDAAF---- ---------S-KSVLPVKP----VEIEIETPQQAKARERS-------------ERIKVEF ETYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRSHTCSQPDLLAVGLSIIPARFT---- --RVPPQDVDAGYLSNLVKW----------FIGTFTVNADLSTNEGD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLPTRLVLSLQPLPLKLP A--------------------------------------AK------------------- ------------------------------------------------GK-KA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PK------------------------- ------------------------------------------------------------ -------------EISAESPG---GSLETHSPVPESQTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTRQED------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TSS---------------------KGPGGPSAKGKRSKAAAV--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GKKRREPSCSGEEEHKAGGQQE------------------ --------------------------------DTRRHRH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASKVSYKEESGS--- ----------------------------------------------------------DK IS-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--AHHSSDEDSE-------------------------PGLSRQRRAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSDSR TQRGRHSKHPSFPAAS-----TSSSSSKS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KISNDG------------------- ------------------EG---------------------------------------- ------------------------------------------------------------ ---------A------ERGK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------V---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWVCVDCVH-GVVGQALTCYKYATKPMTYV VGIDGDGWVRDVTQRYDPAWMTVTRKCRVDAKWWAETLRPYQSPLVEREKKEDSEF-QAK HLGQPLPTVIGTYKNHPLYVLKRHLLKYEAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARKARLAEPQLQDHNDLGLFGEWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLSLPNLH RVARKLDIDCAQAIT-----GFDFHKGYSHPITDGYIVCEEYKDVLLAAWENEQALIEKR EKEKREKRALGNWKLLVRGLLIRERLKLRY----------GDKSEAGAPP---------- ---------------------------AP------AGGGLSSD-EE------EGT----- ------------SSQA-EASRILAASWPQNRE--------------------A--E-EE- ------QKPK-CPK---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFER-L >ENSNVIP00000012812 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GLIRSVRQGRCGVFSPVGRSPLSAFRGVVRHSLGESC LGNM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------V-------------------------------------------------- ------------RKRAAGREPQGREP-CGRKAKGESMAGR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VEKEA--------------------- -------------------DVL-------------------------------------- -------------EDK--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- ----------------------------------KTRLLSKGSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGPAHGPAKKKVA-KVTVKSENPTVVKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EEF----------- -------------------RDFTKGGKKAQPPRREAAV---------------------- -------------------------DKGSCEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------E----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GET------------VPGDMGENTAF---- ---------S-ESVLPVEP----VEIEIETPQQAKARERS-------------ERIKVEF ETYLRRMMKRFSKEVHEDTHKVHLLCLLANGFYRSNICNQPDLLAISLSIIPARFT---- --RVPPQDVDACYLSNLVKW----------FVGTFTVNADLSTNERD-----DLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLSTRLVLSLQPIPLKLP P--------------------------------------AK------------------- ------------------------------------------------GK-KA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PK------------------------- ------------------------------------------------------------ -------------VTSVEGAG---GSLETCSPVLESQTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSQ GTRQEV------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TSS---------------------KGPGRPSAKGKRSKAATV--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------RKKQREPS-SGEEEHKAGGQQE------------------ --------------------------------DTERRRH--------------G------ -----------------------------------------------------------R E-----------------------------------------RQVASRVSYKEESGS--- ----------------------------------------------------------DK GS-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--AHHSSDEDSE-------------------------PGLPR-------QR SKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSRSDSR TQRGRHPKHPSFPAAT-----TSSSSSKS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KISSDG------------------- ------------------EG---------------------------------------- ------------------------------------------------------------ ---------A------ERGK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWVCVDCVH-GVVGQALSCYKYATKPMTYV VGIDGDGWVRDVTQRYDPDWMTATRKCRVDAKWWAETLRPYQSPLVEREKKEDSEF-QAK HLGQPLPTVIGTYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARKARLAEPQLQDHNDLGLFGEWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHKGYSHPITDGYIVCEEYKDVLLAAWEKEQALIEKR EKEKREKRALGNWKLLVRGLLIRERLKLRY----------GDEREERALQ---------- ---------------------------GP------AGGGLSSD-EE------EGT----- ------------SSQA-EASRILAASWPQNRE--------------------A--E-EE- ------QKPK-CPK---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KAAAASHLFPFER-L >ENSPPRP00000022196 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------V-------------------------------------------------- ------------RKRAAGREPQGREP-CGRKAKGKSTARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EEKEA--------------------- -------------------DVL-------------------------------------- -------------QDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- ----------------------------------KRSLLSKVSRETR-KR---------- ------------------------------------------------------------ -----------GCSDPGGPAHSPAKRKAA-KVTVKSENAK-VKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EDF----------- -------------------RDFASAPKKAHHPKREAAV---------------------- -------------------------DKGSCEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESDD-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VPSDAGENAAF---- ---------S-KSVLPVKP----VEIEIETPQQAKARERS-------------ERIKMEF ETYLRRMMNRFSKEVREDTHKVHLLCLLANGFYRSNICNQPDLLAIGLSIIPARFT---- --KVPPQDVDACYLSNLVKW----------FIGTFTVNADLSTNEQD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLPTRLVLSLQPVPLKLP T--------------------------------------AK------------------- ------------------------------------------------GK-KA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERSTEGPG---GSLETSSPVPENQAK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKSGK GTGQES------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TPS---------------------AGTGSPSARGKRSKAAAV--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GKKRRGPSSSEEEECKAGEQEE------------------ --------------------------------GRRRRRQ--------------G------ -----------------------------------------------------------R E-----------------------------------------RQVASRVSYKEESGS--- ----------------------------------------------------------ER GS-----------------------------NG------------------SD------- --------------------------------------------------------FE-- ----PSSGE--ARHSSDEDSE-------------------------PGLPRQRRAPGPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSDSR THRGKHPRRSGFPAAS-----TSSSSSKS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KISSDG------------------- ------------------EG---------------------------------------- ------------------------------------------------------------ ---------A------QRGT---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GRDQWLEVFCEQEEKWVCVDCVH-GVVGQAVACYKYATKPMTYV VGIDGDGWVRDVTQRYDPAWMTTTRKCRVDAKWWAETLRPYQSPLVEREKKEDSEF-QAK HLGQPLPTVIGTYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARKARLAEPQLQDQNDLGLFGRWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RIARKLDIDCVQAIT-----GFDFHKGYSHPITDGYIVCEEYKDVLLAAWENEQALIEKK EKEKREKRALGNWKLLVKGLLIRERLKIRY----------GDKSEAVAAQ---------- ---------------------------AH------AGGGLSSD-EE------EGT----- ------------SSQA-EASRILAASWPQNRE--------------------A--E-EE- ------QKPQ-CPK---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSPTIP00000013594 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------V-------------------------------------------------- ------------RKRAAGREPQGREP-CGRKAKGKSTARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EEKEA--------------------- -------------------DVL-------------------------------------- -------------QDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- ----------------------------------KRSLLSKVSRETR-KR---------- ------------------------------------------------------------ -----------GCSDPGGPAHSPAKRKAA-KVTVKSENAE-VKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EDF----------- -------------------RDFASAPKKAHHPKREAAV---------------------- -------------------------DKGSCEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESDD-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VPSDAGENAAF---- ---------S-KSVLPVKP----VEIEIETPQQAKARERS-------------ERIKMEF ETYLRRMMNRFSKEVREDTHKVHLLCLLANGFYRSNICNQPDLLAIGLSIIPARFT---- --KVPPQDVDACYLSNLVKW----------FIGTFTVNADLSTNEQD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLPTRLVLSLQPVPLKLP T--------------------------------------AK------------------- ------------------------------------------------GK-KA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERSTEGPG---GSLETSSPVPENQAK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKSGK GTGQES------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TPS---------------------AGTGSPSARGKRSKAAAV--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GKKRRGPSSSEEEERKAGGQEE------------------ --------------------------------GPRRRRQ--------------G------ -----------------------------------------------------------R E-----------------------------------------RQVASRVSYKEESGS--- ----------------------------------------------------------ER GS-----------------------------NG------------------SD------- --------------------------------------------------------FE-- ----PSSGE--ARHSSDEDSE-------------------------PGLPRQRRAPGPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSDSR THRGRHPRRSGFPAAS-----TSSSSSKS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KISSDG------------------- ------------------EG---------------------------------------- ------------------------------------------------------------ ---------T------QRGT---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GRDQWLEVFCEQEEKWVCVDCVH-GVVGQAVACYKYATKPMTYV VGIDGDGWVRDVTQRYDPAWMTTTRKCRVDAKWWAETLRPYQSPLVEREKKEDSEF-QAK HLGQPLPTVIGTYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARKARLAEPQLQDQNDLGLFGRWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RIARKLDIDCVQAIT-----GFDFHKGYSHPITDGYIVCEEYKDVLLAAWENEQALIEKK EKEKREKRALGNWKLLVKGLLIRERLKIRY----------GDKSEAVAAQ---------- ---------------------------AH------AGGGLSSD-EE------EGT----- ------------SSQA-EASRILAASWPQNRE--------------------A--E-EE- ------QKPQ-CPK---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSFCAP00000001725 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------V-------------------------------------------------- ------------RKRAAGREPQGREP-CGRKAKGKSTARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EEKEA--------------------- -------------------DVL-------------------------------------- -------------QDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- ----------------------------------KRSLLSKVSRETR-KR---------- ------------------------------------------------------------ -----------GCSDPGGPAHSPAKRKAA-KVTVKSENAE-VKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EDF----------- -------------------RDFASAPKKAHHPKREAAV---------------------- -------------------------DKGSCEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESDD-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VPSDAGENAAF---- ---------S-KSVLPVKP----VEIEIETPQQAKARERS-------------ERIKMEF ETYLRRMMNRFSKEVREDTHKVHLLCLLANGFYRSNICSQPDLLAIGLSIIPARFT---- --KVPPQNVDACYLSNLVKW----------FIGTFTVNADLSTNEQD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLPTRLVLSLQPVPLKLP T--------------------------------------AK------------------- ------------------------------------------------GK-KA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERSTEGPG---GSLETSSPVPENQAK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKSSK GTGQEG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TPS---------------------AGTGSPSARGKRSKPAAV--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GKKRRGPSSSEEEERKAGGQEE------------------ --------------------------------GPRRRRQ--------------G------ -----------------------------------------------------------R E-----------------------------------------RQVASRVSYKEESGS--- ----------------------------------------------------------ER GS-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----PSSGE--AHHSSDEDSE-------------------------PGLPRQRRAPGPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSDSR THRGRHPRRSGFPAAS-----TSSSSSKS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KISSDG------------------- ------------------EG---------------------------------------- ------------------------------------------------------------ ---------A------QRGT---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GRDQWLEVFCEQEEKWVCVDCVH-GVVGQAVACYKYATKPMTYV VGIDGDGWVRDVTQRYDPAWMTTTRKCRVDAKWWAETLRPYQSPLVEREKKEDSEF-QEK HLGQPLPTVIGTYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARKARLAEPQLQDQNDLGLFGRWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RIARKLDIDCVQAIT-----GFDFHKGYSHPITDGYIVCEEYKDVLLAAWENEQALIEKK EKEKREKRALGNWKLLVKGLLIRERLKIRY----------GDKSEAVTAQ---------- ---------------------------AH------EGGGLSSD-EE------EGT----- ------------SSQA-EASRILAASWPQNRE--------------------A--E-EE- ------QKPQ-CPK---KTKRA-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSMLUP00000009722 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAVRGPRGREP-RGQKAKG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EEKEAV-QSKSCGH------------ ------------------LDVF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCHDPGGSPDGPVKKKVA-KVTVKSESLKVKKDEVF------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EDF----------- -------------------RDFTSACKKAYHPKRESAV---------------------- -------------------------DKDSHEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----DD----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEL------------VPDDGAENATF---- ---------S-QSVLPVKP----VEIEIETPEQAKARQRS-------------EKIQMEF ETALRRLMKRFNKEVHEDTHKVHLLCLLANGFYRNSICNQLDLQAISLSIIPIRFT---- --RVPPQDVDISYLSNLVKW----------FIGTFTVNSDLSVSEHD-----SLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------VFLLMLRALQLPTRLVLSLQPVPLKLS V--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------K------------------------- ------------------------------------------------------------ -------------ESSTESPE---GSSETSSQVSENQTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSR GTRKEG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TSS---------------------KGTNSPSAKGKRSKAAAV--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GKKRREPSSSEEEEGKAGEQEE------------------ ---------------------------------TQRQLR--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DK TN-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--AHPPSDEDSE-------------------------PGPSRQRRAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSDSR TRRGSHPKHPDSPAAS-----TSSSSSKN------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------ER---------------------------------------- ------------------------------------------------------------ ---------T------EKGK---------------------------------------- ---------------------------------T-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEREEKWVCVDCVH-GVVGQAVTCYRYATKPMAYV VGFDNDGWVRDVTQRYDPAWMTATRKCRVDAKWWAETLRPYQSPLVEREKKEDLEF-QAK HLDQPLPTVIGTYKNHPLYALKRHLLKYEAIYPETAAIIGYCRGEAVYS--RDCVQTLHS RDTWLKQGRVVRLGEVPYKMVKGYSNRARRARLAEPQLQDQNDLGLFGKWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLN RVARKLGIDCVPAVT-----GFDFHKGYSHPITDGYIVCEEYKDVLLAAWENEQALIEKK EKEKREKRALENWKLLAKGLLIRERLKLRY----------GAKSGAETPH---------- ----------------------------P------AGGGLSSD-EE------EGT----- ------------SSQA-EAAKILAASWPQNRE--------------------A--K-EE- ------QKPR-CPK---KTKRE-------------------------------------- ------------------------------------------------------------ --------------------------------------------KAEASHLFPFEK-L >ENSPVAP00000015843 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---MG--------PKRSTGRKPRGRKR--------------------------------- ------------------------------------------------------------ ---------------------------------------------RGQKAKGEST----- AGREEEEAAA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DVV-------------------------------------- -------------EDK--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLPKVSQGKR-KR---------- ------------------------------------------------------------ -----------GFSDPGCSTDGRAKKKVA-KVTVKSENLKVIKDEAF------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EDF----------- -------------------RDFTSACKKAHHPKREAAM---------------------- -------------------------DKGSHEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VPGDAGENAAF---- ---------S-QSVLPMKP----VEIEIETPEQAKARERS-------------EKIQMEF ETNLRRLMKRFNKEVHEDTHKVHLLCLLANGFYRNNICNQPDLQAIGLSIIPARFT---- --RVPPQDVDIYYLSNLVKW----------FIGTFTVNTDLSTNEQD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLPTRLVLSLQPVPLKLS A--------------------------------------TK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ESSTECPG---GSAETSSQVPENQTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSR ETRQED------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TTS---------------------KSAGSPSVKGKRSKAAAIKKKQKEPPS------ --------------------------------------SG------------------EE E---------VKA------------------EKQEKKT-----QGRV------------- -------------------RGQK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DK AS-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--AHHSSSEDCE-------------------------PGPSRQRRASAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSDSR TQHGSHPKHPGFPAAS-----ASSSSSKS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------T------ERGK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVNQWLEVFCEQEEKWTCVDCVH-GVVGQSPTCYRYATKPMTYV VAIDNNGWVRDVTQRYDPAWMTATRKCRVDAKWWAETLRPYQSPLVEREKKEDLEF-QAK HLEQPLPTVIGTYKNHPLYALKRHLLKYEAIYPETAAIIGYCRGEAVYS--RDCVHILHS RDTWLKQGRVVRLGEVPYKMVKGYSNRARRARLAEPQLQDHNDLGLFGKWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLQ RVARKLDIDCVQAIT-----GFDFHKGYSHPITEGYIVCEEYKDVLLAAWENEQALIEKK EKEKKEKRALGNWKLLAKGLLIRERLKLRY----------GAKSEAVAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------A--E-EE- ------QKPK-YPK---RTRRE-------------------------------------- ------------------------------------------------------------ --------------------------------------------KATASHLFPFER-L >ENSECAP00000013224 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGSGRRGREP-RGQKAKGESAARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EQKEA--------------------- -------------------DVF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKKLLSKVSRGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSADGPAKKKVA-KVTGKSEKLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ----------------------------------------------EDF----------- -------------------RDSPSARKKARRPKKEAAM---------------------- -------------------------DKGSHGG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VPGDAGENTAF---- ---------S-KSALPVEP----VEIEIETPEQAKARERS-------------EKVKMEF ETYLRRMVKRFNKEVHEDTHKVHLLCLLANGFYRNSVCNQPDLQAIALSILPARFT---- --RVPPRDVDICHLSDLVKW----------FIGTFTVNADLSTSERD-----GLQTTLER RFAIYSARDDQELVH--------------------------------------------- ---------------------------------IFLLILRALQLPTRLVLSLQPIPLKLS A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERSTEGPR---GSSETSSQVPENQTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSR GTRQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TSS---------------------EGTSNPGTKGKRSKPAAG--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GRRRRDPSSSGEEEGEAGAREE------------------ --------------------------------HTPRRLR--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DK AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSEE--AQHSSDEDSE-------------------------PGLPRRRRARAPQR TKT--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------ESKSDSR TQHGRHPKNPGFPATS-----SSSSSSKS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KIHHEG------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------A------EGGK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWMCVDCVH-GVVGQPLTCYRYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAQWWASTLRPYQSPCVEREKKEDLEF-QAK HLDQPLPTAIGTYKNHPLYALKRHLLKFEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGFSNRARKARLAEPQLQDQNDLGLFGQWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLDIDCVQAVT-----GFDFHGGYCHPVTDGYIVCEEYKDVLLAAWEKEQALIEKK EKEKKEKRALGNWKLLVKGLLIRERLRLRY----------GAKCEAAAPH---------- ---------------------------AD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------A--E-EE- ------PKPK-CPK---TKRGK-------------------------------------- ------------------------------------------------------------ --------------------------------------------KAAASHLFPFER-L >ENSEASP00005022624 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGSGRRGREP-RGQKAKGESAARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EQKEA--------------------- -------------------DVF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKKLLSKVSRGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSADGPAKKKVA-KVTGKSEKLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ----------------------------------------------EDF----------- -------------------RDSPGARKNARRPKKEAAM---------------------- -------------------------DKGSHGE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VPGDAGENTAF---- ---------S-KSALPVEP----VEIEIETPEQAKARERS-------------EKVKMEF ETYLRRMVKRFNKEVHEDTHKVHLLCLLANGFYRNSVCNQPDLQAIALSILPARFT---- --RVPPRDVDICHLSDLVKW----------FIGTFTVNADLSTSERD-----GLQTTLER RFAIYSARDDQELVH--------------------------------------------- ---------------------------------IFLLILRALQLPTRLVLSLQPIPLKLS A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERSTEGPR---GSSQTSSQVPENQTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSR GTRQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TSS---------------------EGTSNPGTKGKRSKPAAG--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------GRKRRDPSSSGEEEGEAGAREE------------------ --------------------------------HTPRRLR--------------A------ -----------------------------------------------------------Q E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DK AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSEE--AQHSSDEDSE-------------------------PGLLRRRRARAPQR TKT--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------ESKSDSR TQHGRHPKNPGFPATS-----SSSSSSKS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------K----GK--------------------------------- -----------------------------------KIHREG------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------A------EGGK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWMCVDCVH-GVVGQPLTCYRYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAQWWASTLRPYQSPCVEREKKEDLEF-QAK HLDQPLPTAIGTYKNHPLYALKRHLLKFEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGFSNRARKARLAEPQLQDQNDLGLFGQWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLDIDCVQAVT-----GFDFHGGYCHPVTDGYIVCEEYKDVLLAAWEKEQALIEKK EKEKKEKRALGNWKLLVKGLLIRQRLRLRY----------GAKCEAAAPH---------- ---------------------------AD------AGGGLSSD-EE------EGT----- ------------SSQA-ETARILAASWPQNRE--------------------A--E-EE- ------PKPK-CPK---TKRGK-------------------------------------- ------------------------------------------------------------ --------------------------------------------KAAASHLFPFER-L >ENSRBIP00000007949 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGEPRGRET-RSQKSKAKSKARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSAGGPAKKKVA-KVTVKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RDFPSDLKKAHHLKRGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NK----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVRESTAF---- ---------S-QSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETHLRRAMKRFNKEVHADTHKVHLLCLLANGFYRNSICSQPDLHAIGLSIIPAHFT---- --RVLPRDVDTYYLANLVKW----------FIGTFTVNAELSASEQD-----NLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADLE---GCSETSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGKRSK------------------- ------------------------------------------------------------ ------------GGRKKRRKLSSSEEDQGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PSPPKQRKAPTPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR TQCGSHHKDPSLPAA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------ER---------------------------------------- ------------------------------------------------------------ ---------A------EKRS---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYRYATKPVTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIEKK EKEKREKRAVGNWKLLAKGLLIRERLKRRY----------GPKSEAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKSGPR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSRROP00000029859 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGEPRGRET-RSQKSKAKSKARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSAGGPAKKKVA-KVTVKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RDFPSDLKKAHHLKRGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NK----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVRESTAF---- ---------S-QSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETHLRRAMKRFNKEVHADTHKVHLLCLLANGFYRNSICSQPDLRAIGLSIIPAHFT---- --RVLPRDVDTYYLANLVKW----------FIGTFTVNAELSASEQD-----NLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADLE---GCSETSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGKRSK------------------- ------------------------------------------------------------ ------------GGRKERRKLSSSEEDQGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PSPPKQRKAPTPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR TQCGSHHKDPSLPAA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------ER---------------------------------------- ------------------------------------------------------------ ---------A------EKRS---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GIDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYRYATKPVTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIEKK EKEKREKRAVGNWKLLAKGLLIRERLKRRY----------GPKSEAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRD--------------------D--E-EK- ------QKLKSGPR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSCANP00000005827 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGESRGRET-RSQKSKAKSKTRR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSAGGPAKKKVA-KVTVKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RDFPSDLRKAHHPKRGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVRESTAF---- ---------S-QSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETHLRRAMKRFNKEVHADTHKVHLLCLLANGFYRNNICSQPDLRAVGLSIIPAHFT---- --RVLPRDVDTYYLSNLVKW----------FIGTFTVNAELSASEQD-----NLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADLG---GCSETSSQVLENRTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGKRSK------------------- ------------------------------------------------------------ ------------GGRKKRRKLSSSEEDQGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVVSRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PGPPKQRKAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR TQCGSHHKDPSLPAA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EKRS---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVNQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYRYATKPVTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIEKK EKEKREKRAVGNWKLLAKGLLIRERLKRRY----------GPKSEAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKSGPR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSPTEP00000010196 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGEPRGRET-RSQKSKAKSKARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSAGGPAKKKVA-KVTVKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RDFPSDLKKAHHLKRGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVRESTDF---- ---------S-QSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETHLRRAMKRFNKEVHADTHKVHLLCLLANGFYRNNICSQPDLRAIGLSIIPAHFT---- --RVLPRDVDTYYLSNLVKW----------FIATFTVNAELSASEQD-----NLQTTLER RFAIYSARDDEELVHPQKKQGKSNHLSHHNMAPHTGLSPEAVAVIKE------------- ----------RCWDLETRVGRPCPSTLSLLPLKIFLLILRALQLLTRLVLSLQPIPLKSA A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADLG---GCSETSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGKRSK------------------- ------------------------------------------------------------ ------------GGRKKRRKLSSSEEDQGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRLH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVVSRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PGPPKQRKAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR TQCGSHHKDPSLPAA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EKRS---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYRYATKPVTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIICEEFKDVLLTAWENEQAVIEKK EKEKREKRAVGNWRLLAKGLLIRERLKRRY----------GPKSEAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKSGPR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSMNEP00000029866 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGEPRGRET-RSQKSKAKSKTRR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLVSRVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSAGGPAKKKVA-KVTVKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RDFPSDLKKAHHLKKGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVRESTAF---- ---------S-QSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETHLRRAMKRFNKEVHEDTHKVHLLCLLANGFYLNNICSQPDLRAIGLSIIPAHFT---- --RVLPRDVDTYYLSNLVKW----------FIGTFTVNAELSASEQD-----NLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADLG---GCSETSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGKRNK------------------- ------------------------------------------------------------ ------------GGRKKRRKPSSSEEDQGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PGPPKQRKAPAPRR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR TQCGSHRKDPSLPVA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EERS---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYRYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWAETLRPYQSPFMEREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFRDVLLTAWENEQAIIEKK EKEKREKRALGNWKLLAKGLLIRERLKRRY----------GPKSEAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKSGPR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSMFAP00000017437 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGEPRGRET-RSQKSKAKSKTRR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLVSRVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSAGGPAKKKVA-KVTVKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RDFPSDLKKAHHLKKGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVRESTAF---- ---------S-QSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETHLRRAMKRFNKEVHEDTHKVHLLCLLANGFYLNNICSQPDLRAIGLSIIPAHFT---- --RVLPRDVDTYYLSNLVKW----------FIGTFTVNAELSASEQD-----NLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADLG---GCSETSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGKRNK------------------- ------------------------------------------------------------ ------------GGRKKRRKPSSSEEDQGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PGPPKQRKAPAPRR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR TQCGSHRKDPSLPVA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EERS---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYRYATKPLTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFRDVLLTAWENEQAIIEKK EKEKREKRALGNWKLLAKGLLIRERLKRRY----------GPKSEAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKSGPR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSMMUP00000043928 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGEPRGRET-RSQKSKAKSKTRR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLVSRVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSAGGPAKKKVA-KVTVKSENLKVIKDEAF------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RDFPSDLKKTHHLKKGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVRESTAF---- ---------S-QSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETHLRRAMKRFNKEVHEDTHKVHLLCLLANGFYLNNICSQPDLRAIGLSIIPAHFT---- --RVLPRDVDTYYLSNLVKW----------FIGTFTVNAELSASEQD-----NLQTTLER RFAIYSARDDEELVHPQKKQGKSNHLSHHNVAPHTGLSPEAVAVIKE------------- ----------RCWDLETRVGRPCLSTLSLLPLKIFLLILRALQLLTRLVLSLQPIPLKSA A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADLG---GCSETSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGKRNK------------------- ------------------------------------------------------------ ------------GGRKKRRKPSSSEEDQGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEDSGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PGPPKQRKAPAPRR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR TQCGSHRKDPSLPVA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EERS---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYRYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFRDVLLTAWENEQAIIEKK EKEKREKRALGNWKLLAKGLLIRERLKRRY----------GPKSEAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKSGPR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSTGEP00000017721 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGEPRRRET-RSQKSKAKSKTRR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLVSRVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSAGGPAKKKVA-KVTVKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RDFPSDLKKAHHPKKGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVRESTAF---- ---------S-QSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETHLRRAMKRFNKEVHEDTHKVHLLCLLANGFYRNNICSQPDLRAIGLSIIPAHFT---- --RVLPRDVDTYYLSNLVKW----------FIGTFTVNAELSASEQD-----NLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADLG---GCSETSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGKRNK------------------- ------------------------------------------------------------ ------------GGRKKRRKPSSSEEDQGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PGPPKQRKAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR TQCGSHRKDPSLPVA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EKRS---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYRYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFRDVLLTAWENEQAIIEKK EKEKREKRALGNWKLLAKGLLIRERLKRRY----------GPKSEAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKSGPR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSPANP00000005147 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGEPRGRET-RSQKSKAKSKTRR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLVSRVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSAGGPAKKKVA-KVTVKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RDFPSDLKKAHHPKKGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVRESTAF---- ---------S-QSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETHLRRAMKRFNKEVHEDTHKVHLLCLLANGFYRNNICSQPDLRAIGLSIIPAHFT---- --RVLPRDVDTYYLSNLVKW----------FIGTFTVNAELSASEQD-----NLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADLG---GCSETSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGKRNK------------------- ------------------------------------------------------------ ------------GGRKKRRKPSSSEEDQGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PGPPKQRKAPALQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR TQCGSHRKDPSLPVA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EKRN---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYRYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFRDVLLTAWENEQAIIEKK EKEKREKRALGNWKLLAKGLLIRERLKRRY----------GPKSDAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKSGSR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSMLEP00000035079 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGREPRGRET-RSQKSKAKSKTRR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLASRVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSAGGPAKKKVA-KVTVKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RDFPSDLKKAHHPKKGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVRESTAF---- ---------S-QSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETHLRRAMKRFNKEVHEDTHKVHLLCLLANGFYRNNICSQPDLRAIGLSIIPAHFT---- --RVLPRDVDTHYLSNLVKW----------FIGTFTVNAELSASEQD-----NLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADLG---GCSETSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGICKPSAKGKRNK------------------- ------------------------------------------------------------ ------------GGRKKQRKPSSSEEDQGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PGPPKQRKGPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR TQCGSHRKDPSLPVA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EKRS---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYKYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWTETLRPYQSPFMDREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFRDVLLTAWENEQAIIEKK EKEKREKRALGNWKLLAKGLLIRERLKRRY----------GPKSEAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKSGPR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSCATP00000026656 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGELRGRET-RSQKSKAKSKTRR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------EEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLVSRVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSAGGPAKKKVA-KVTVKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RDFPSDLKKAHHPKKGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVRESTAF---- ---------S-QSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETYLRRAMKRFNKEVHEDTHKVHLLCLLANGFYRNNICSQPDLRAIGLSIIPAHFT---- --RVLPRDVDTYYLSNLVKW----------FIGTFTVNAELSASEQD-----NLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADLG---GCSETSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKRSAKGKRNK------------------- ------------------------------------------------------------ ------------GGRKKQRKPSSSEEDQGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PGPPKQRKALAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSRSASR TQCGSHRKDPSLPVA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EKRS---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYKYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFRDVLLTAWENEQAIIEKK EKEKREKRALGNWKLLAKGLLIRERLKRRY----------GPKSEAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKSAPR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSPPYP00000014988 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGREPRGREP-RSQKSKAKSKARRE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------EEEEEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLPSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSHPGRSADGPAKKKVA-KVTVKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDL----------- -------------------RDVPSDLKKAHHPKRGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESEN-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP------------VLGDVRESTAF---- ---------S-RSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETHLRRAMKRFNKEVHEDTHKVHLLCLLANGLYRNNICSQPDLHAIGLSIVPARFT---- --RVLPRDVDTYYLSNLVKW----------FIGTFTVNAELSASEQD-----NLQSTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLHPIPLKSA T--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADPG---ASSETSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGKRNK------------------- ------------------------------------------------------------ ------------GGRKKRSKPSSSEEDEGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PGPPKQRKAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR TQRGSHHKDPSLPAA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EKRS---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYKYATKPVTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAIIEKK EKEKREKRALGNWKLLAKGLLIRERLKRRY----------GPKSEAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKGGPK---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSGGOP00000009760 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGEPRGREP-RSQKSKAKSKARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EEEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSHPGGSADGPAKKKVA-KVTVKSENLKIIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDL----------- -------------------RDFPSDLKKAHHPKRGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESEN-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVRESTAF---- ---------S-RSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETHLRRAMKRFNKEVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIIPARFT---- --RVLPRDVDTYYLSNLVKW----------FIGTFTVNAELSASEQD-----NLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA T--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADPG---GSSETSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGKRNK------------------- ------------------------------------------------------------ ------------GGRKKRSKPSSSEEDEGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------PTQRRRH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PGPPKQRKAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR TQRGSHHKDPSLPAA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMCSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EKRS---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GIDQWLEVFCEQEEKWVCVDCVH-GVVGQPLTCYKYATKPMTYV VGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERK EKEKREKRALGNWKLLAKGLLIRERLKRRY----------GPKSEAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKGGPK---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSP00000285021 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGEPRGREL-RSQKSKAKSKARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EEEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSHPGGSADGPAKKKVA-KVTVKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDL----------- -------------------RDFPSDLKKAHHLKRGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESEN-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVRESTAF---- ---------S-RSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIIPARFT---- --RVLPRDVDTYYLSNLVKW----------FIGTFTVNAELSASEQD-----NLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA T--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADPG---GSSETSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCRPSAKGKRNK------------------- ------------------------------------------------------------ ------------GGRKKRSKPSSSEEDEGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PGPPKQRKAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR THRGSHRKDPSLPAA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMCSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EKRS---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GIDQWLEVFCEQEEKWVCVDCVH-GVVGQPLTCYKYATKPMTYV VGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERK EKEKKEKRALGNWKLLAKGLLIRERLKRRY----------GPKSEAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKGGPK---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEQ-L >ENSPTRP00000051558 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGEPRGREL-RSQKSKAKSKARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EEEEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLSKVSQGKR-KR---------- ------------------------------------------------------------ -----------HCSHPGGSADGPAKKKVA-KVTVKSENLKVIKDEAF------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDL----------- -------------------RDFPSDLKKAHHLKRGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESEN-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVRESTAF---- ---------S-RSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETYLRRAMKRFNKEVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIIPARFT---- --RVLPRDVDTYYLSNLVKW----------FIGTFTVNAELSASEQD-----NLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA T--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADPG---GSSETSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTRKPSAKGKRNK------------------- ------------------------------------------------------------ ------------GGRKKRSKPSSSEEDEGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PGPPKQRKAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR TQRGSHHKDPSLPAA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMCSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EKRS---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GIDQWLEVFCEQEEKWVCVDCVH-GVVGQPLTCYKYATKPMTYV VGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERK EKEKREKRALGNWKLLAKALLIRERLKRRY----------GPKSEAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKGGPK---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSPPAP00000041697 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGEPRGREL-RSQKSKAKSKARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EEEEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSHPGGSADGPAKKKVA-KVTVKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDL----------- -------------------RDFPSDLKKAHHLKRGA------------------------ --------------------------------TM-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESEN-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVRESTAF---- ---------S-RSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKLEF ETYLRRAMKRFNKEVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIIPARFT---- --RVLPRDVDTYYLSNLVKW----------FIGTFTVNAELSASEQD-----NLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA T--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERLTADPG---GSSETSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGKRNK------------------- ------------------------------------------------------------ ------------GGRKKRSKPSSSEEDEGPGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSDEDSE-------------------------PGPPKQRKAPTPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR TQRGSHHKDPSLPAA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMCSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EKRS---------------------------------------- ---------------------------------I-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GIDQWLEVFCEQEEKWVCVDCVH-GVVGQPLTCYKYATKPMTYV VGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERK EKEKREKRALGNWKLLAKALLIRERLKRRY----------GPKSEAAAPH---------- ---------------------------TD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKGGPK---KTKRERKQQLP-------------------------------- --------------------TCS------------------------------------- ---------------------------------HLRSCELSAH--------------- >ENSCCAP00000008434 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGKPRGRQP-RSQKSKGKRKCRR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EEEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSADGPAKKKVA-KVTVKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDV----------- -------------------RDFPSDLKKAHHLKRGA------------------------ --------------------------------TV-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDGKESTAF---- ---------S-PSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKMEF ETYLRRAMKRFNKEVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSVVPSRFT---- --RVPPRDVDTYYLSNLVKW----------FIGTFTVNADLSASEQD-----NLQATLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------KRLTADPG---GSSESSSQVLESHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGK-NK------------------- ------------------------------------------------------------ ------------ADRKKQSKLSSSEEDEGLGDKQEK------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSNEDSE-------------------------PGPPKQRKVPAPQR TKT--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASK TQRGNHHKDLSLPAA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----G---------------------------------- -----------------------------------KMSSNG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------V------EKRS---------------------------------------- ---------------------------------L-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYRYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWAETLRPYQSPFLDREKKEDMEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGYSNRARKARLAEPQLRDENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAIIEKK EKEKREKRALGNWKLLTKGLLIRERLKRRY----------GPKSEAAASH---------- ---------------------------SD------AGGGLSSD-EE------EGT----- ------------SSQV-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKGGPK---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKAAASHLFPFEK-L >ENSSBOP00000011255 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGGPRGRQL-RSQKSKGKSKARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EEEEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLSRVSQGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSADGPAKKKVA-KVTVKSENLKIIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDV----------- -------------------RDFPSDLKKAHHPKRGA------------------------ --------------------------------TL-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDGKESTAF---- ---------S-PSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKMEF ETYLRRAMKRFNKEVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIVPSRFT---- --RVPPRDVDTYYLSNLVKW----------FIGTFTVNADLSASEQD-----NLQATLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------KRLTADPE---GSSESSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGK-NK------------------- ------------------------------------------------------------ ------------ANRKKRSKLSSSEEDEGLGDKQEE------------------------ ------------------------------------------------------------ --------------------------------ATQRRLH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSNGE--ASDPSNEDSE-------------------------PCPPKQRKVPAPQG TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSVSK TQRGSHHKDLSLPVA-------SSGSSNS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----G---------------------------------- -----------------------------------KMSSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EKRS---------------------------------------- ---------------------------------P-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYRYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWAETLRPYQSPFLDREKKEDMEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGYSNRARKARLAEPQLRDENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAIIEKK EKEKREKRALGNWKLLTKGLLIRERLKRRY----------GPKSEAAASH---------- ---------------------------SD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRD--------------------D--E-EK- ------QKLKGGPK---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKAAASHLFPFEK-L >ENSCJAP00000045013 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGEPRGRQP-RSQKSKGKSKARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EEEEEE--------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLSEREKGKR-KR---------- ------------------------------------------------------------ -----------GCSDPGVSADGPAKKKVA-KVTVKSENLKVIKDEAL------------- ----------------------------------------------G------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDV----------- -------------------RDFPSDLKKAHHPKRGA------------------------ --------------------------------TV-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------MLGDGKESTAF---- ---------S-PSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKMEF ETYLQRAMKRFNKEVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIVPSRFT---- --RVLPRDVDTYYLSNLVKW----------FTGTFTVNADLSACEQD-----NLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA A--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------KRLTVDPG---GSSESSSQVLENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGK-NK------------------- ------------------------------------------------------------ ------------ADRKKWCKPSSSEEDEGLGDKQKE------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--ASDPSNEDSE-------------------------PGPPKQRKAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASK TQCGSHHKDPSLPAA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EQRN---------------------------------------- ---------------------------------L-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYRYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWAETLRPYQSPFLDREKKEDMEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGYSNRARKARLAEPQLRDENDLGLFGYWQTEEYQPPVA IDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAIIEKK EKEKREKRALGNWKLLTKGLLIRERLKRRY----------GPKSEAAASH---------- ---------------------------SD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKGGPK---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKAAASHLFPFEK-L >ENSANAP00000005999 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LRV----------------- ----------------ES-----GD------GSYLAPRKTDG----------PGRGVMQC ----G------------------------------------------------------- ------------------------------------------------------------ -------------------DS--------------------------------------- -------------RMSLTRSS-----------------------------TVGS------ -----------------HLTSPLGYRIG---FL--------------------------- -------------------DAF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GCRDPGVSADGPAKKKVA-KVTIKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDV----------- -------------------RDFPSDLKKAHHLKRGA------------------------ --------------------------------TV-------------------------- ------------------------------------------------------------ ---------------------------------------------------------NED S----------------------------------------------------------- ------------------------------------------------------------ -----NE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDGKESTAF---- ---------S-PSLLPVKP----VEIEIETPEQAKTRERS-------------EKIKMEF ETYLRRAMKRFNKEVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIVPSRFT---- --RVLPQDVDTYYLSNLVKW----------FIGTFTVNADLSASEQD-----NLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKSA I--------------------------------------AK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------KKLTVDPG---GSSESSSQVLENYTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFA---------------------KGTCKPSAKGK-NK------------------- ------------------------------------------------------------ ------------ADRKKRSKPSSSEEDEGLGGKQEE------------------------ ------------------------------------------------------------ --------------------------------ATQRRPH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DE AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--TSDPSNEDSE-------------------------PGPPKQRKAPAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASK AQRGSHHEDPSLPAA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KMSSDG------------------- ------------------EK---------------------------------------- ------------------------------------------------------------ ---------A------EERS---------------------------------------- ---------------------------------L-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYRYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTVTRKCRVDAEWWAETLRPYQSPFLDREKKEDMEF-QAK HMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAIYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGYSNRARKARLAQPQLRDENDLGLFGYWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAIIEKK EKEKREKRALGSWKLLTKGLLIRERLKRRY----------GPKSEAAASH---------- ---------------------------SD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------D--E-EK- ------QKLKGGPK---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKAAASHLFPFEK-L >ENSTSYP00000004754 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGQTRAHEP-RGQKSKGKSKARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EEKDA--------------------- -------------------NVS-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLSKVSRGQR-KR---------- ------------------------------------------------------------ -----------GCSDPGGSADGPAKKKVA-KVTVKPENLNVIKVEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RNFPSDLKKAHHPKRGA------------------------ --------------------------------TV-------------------------- ------------------------------------------------------------ ---------------------------------------------------------AEG S----------------------------------------------------------- ------------------------------------------------------------ -----DP----------------------------------------------------- ------------------------------------------------------------ -E----DE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVGENTAF---- ---------S-QSVVPVKP----VEIEIETPEQAKTRERS-------------EKIKMEF EAHLRRMMKRFNKEVLEDTHKVHLLCLLANGFYRNSICNQPDLRAIGLSIIPIRFT---- --KVLPQDVDTYYLSNLVKW----------FIGTFTVNADLSVNEQD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLKPIPLKSS A--------------------------------------AK------------------- ------------------------------------------------RK-KS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERSVEAPG---GSSETSSQVLENHGK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PRTRK GAKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TLC---------------------KGTGNPRGNGKRSK------------------- ------------------------------------------------------------ ------------AGRKKQSEPSSSEEEEG---MREK------------------------ ------------------------------------------------------------ --------------------------------AVQRRWH--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVSSRVSYKEESGS--- ----------------------------------------------------------GE AG-----------------------------SS------------------TD------- --------------------------------------------------------FE-- ----LSSGE--AHDPSDEDSE-------------------------PGPPRRSRISTPQR PKS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKGASS TQQGSHQKHPGFPAA-------SSSSSRS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------K----GK--------------------------------- -----------------------------------KMPSDG------------------- ------------------EQ---------------------------------------- ------------------------------------------------------------ ---------A------ERGS---------------------------------------- ---------------------------------P-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCVQEEKWICVDCVH-GVVGQPLTCYRYATKPVTYV VGIDNDGWVRDVTQRYDPAWMTATRKCRVEAEWWAETLRPYQSPFVEREKKEDSEF-QAK HLDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS KDTWLKKARVVRLGEVPYKMVKGYSNRARKARLAEPELREHNDLGLFGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQALIEKK EKEKREKRALGNWKLLAKGLLIRERLRLRY----------GPTSEAAAPH---------- ---------------------------AD------AGGGLSSD-EE------EGT----- ------------SSQA-EAAKILAASWPQNREAEA------------QQTPK-------- -----------GPK---KTRKE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAAASHLFPFEK-L >ENSOGAP00000021556 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRTAGGQ---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------QQEPKSS HQKAKGKSTARCEEAGDHL----------------------------------------- -------------------DVF-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLLSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GRSDPAGSAGGPTKKKVA-KVMVKSENREVRKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------DDF----------- -------------------RDFPSKLKKTQHPKRGAPV---------------------- -------------------------DKGSHKG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------E----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------MPGDVGENSTF---- ---------S-QSLLPVKP----VEIEIETPEQARTRERS-------------EKIKMEF EMHLRRVMKRFNKEVHEDTHKVHLLCLLANGFYRNSICSQPDLRAIGLSIIPTRFT---- --KVLPRDVDSYYLSNLVKW----------FIGTFTVNSDLSVSDQD-----SLQTVLER RFGIYSARNEEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKFS A--------------------------------------AK------------------- ------------------------------------------------GK-KS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------KRSTEDPG---VFSETSSQVPEDHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AKTSK GTKQKE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TSS---------------------KGPGTPGAKGKRSK------------------- ------------------------------------------------------------ ------------AGKKKWSESSSSEEEEGTRGRQEE------------------------ ------------------------------------------------------------ --------------------------------ATQRRPR--------------G------ -----------------------------------------------------------Q K-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DH AG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--AHHLSDEDSE-------------------------PGLPRRRKVPTAQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSASR TQPGSHRKHLGLPAA--------ASSSTS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----SK--------------------------------- -----------------------------------KMSTDG------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------A------ARGS---------------------------------------- ---------------------------------S-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEEKWICVDCVH-GVVGQPLTCYRYATKPITYV VGIDSDGWVRDVTQRYDPDWMTATRKLRVDAEWWAETLRPYQSPFMEREKKEDLEF-QAK HQDQPLPTSVGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRLGEVPYKMVKGFSNRARKARHAEPQLHDQNDLGLFGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLHLPNLH RVARKLGIDCVQAVT-----GFDFHGGYSHPVTDGYIVCEEFRDVLLSAWENEQALIEKK EKEKKEKRALGHWKVLVKGLLIRERLKLRY----------GPKTETAAPH---------- ---------------------------AD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------A--E-EK- ------QK----PKCSQKTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAEASHLFPFEK-L >ENSCCNP00000011474 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRPAGRKPRG------------------------------------- -----------------------------------------------------------C ----GVRGP--------------------------------------------------- ------------------------------------------------------------ ----------KAKGRSTAKP---------------------------------------- ------------------------------------------------------------ ----------------------------------EEKEA--------------------- -------------------DVS-------------------------------------- -------------EDEKPKP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSCLSKGSQGKR-KR---------- ------------------------------------------------------------ -----------GCSNP----EHPAKKKVA-KMTVRSENLKVVKKAAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EDF----------- -------------------RDFPGDSKKTKHPKREVAL---------------------- -------------------------DK--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ D----------------------------------------------------------- ------------------------------------------------------------ -----ND----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------NEP------------VLGDMGENSSF---- ---------S-PSVLPVEP----VEIEIETPEQAKTRERS-------------EKIKMEF ETYLRRMVKRFNREVHEHTHKVHLLCLLANGFYRNNICSQPDLLAIGLSIIPTRFT---- --KVPPRDVDICYLSNLMKW----------FIGTFTVNVDLSVNEQD-----SLQTTLER RFAIYSARDEEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVVSLQPIPLKSS M--------------------------------------AK------------------- ------------------------------------------------AK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERSTAGLG---GFSEPSSQVPENHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK RTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFS---------------------KGTGKPSAKGKRSK------------------- ------------------------------------VATGSKKWRESSSSEEDLGGSRE- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------QRKETQRRLS--------------G------ -----------------------------------------------------------R E-----------------------------------------RRVASGVSYKEESGS--- ----------------------------------------------------------EK TG-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------AHHSSDEDSES ------------GPPRQRRASAPQGTKAVSKSDSRTQSGSHHKQPGFSAVSSRSLSSKRG KKISNEGDIAEGRKTIGVDQWLEVFCEQEAKWICVDCVH-GVVGQPLTCYKYATKPMTYA VGIDSNGWVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPYQSPLVEREKKEDLEF-QAK HLDQPLPTAIGTYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRLGEVPYKMVKGYSNRARKARLAEPHLQDHNDLGLFGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLH RVARKLNIDCVQAIT-----GFDFHGGYSHPVTDGYIICEEFKDVLLSAWENEQALIEKK EKEKREKRALGNWKLLVKGLLIRERLKLRY----------GAKSEAVAPH---------- ---------------------------AD------AGGGLSSD-EE------EGT----- ------------SSQA-EAAKILAASWPQNRK--------------------T--E-EE- ------QAPE-CPK---TTRRR-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKAAAVHLFPFEK-L >ENSDORP00000001970 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VF-------------------------------------- -------------EVEKSKP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KRSCLSKASQAKR-KR---------- ------------------------------------------------------------ -----------G------------------------------------------------ ----------------------------------------------SSDAGG-------- ----------PAKK---------KEAK---------ATAKAENLKG--V----------- ---------------------------------------KEEDVGD-------------- ------G---------------------------------------EDL----------- -------------------RDFASDLKKMKQPKR-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ESPVNTGSEEEDDQESEE-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GEP------------VLGDMGENSSF---- ---------C-QSLLPVKP----VEIEIETPEQVKTRERS-------------EKIKMEF ETYLRRMMKRFSKEVHENTHKVHLLCLLANGFYRNSICQQVDLLAIGLSIIPVRFT---- --RVPPEDVDLSYLSNLMKW----------FIGTFTVNADLSVSEGD-----SLQTTLER RFAVYSARDEEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVVSLQPVPLKLS M--------------------------------------AK------------------- ------------------------------------------------AK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SS------------------------- ------------------------------------------------------------ -------------QRSTEGSR---GTSEPSTHTPESHTKAKISK---------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------RAKHEGTGKAGARGKRSKAAAGSK---DRRESSSEEEQREAKRCP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------H--------------G------ -----------------------------------------------------------R A-----------------------------------------RRVASKVSYKEDSAS--- ----------------------------------------------------------DE AG-----------------------------SS------------------SD------- --------------------------------------------------------FE-- ----LSSGE--DQQSSDEDPR-------------------------PGSKRQKRAPAPRR TKK--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSESESR TPRRSHHKNLGFSAA-------SSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KTSNDG------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------A------EAGR---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEGKWVCVDCVH-GVVGQPLVCHRYATKPMAYV VGFDSDGCVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPYQSPFVERERKEDLEF-QAK HLDQPLPTAIGTYKNHPLYALKRHLLKYEAIYPETAAVLGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRLGEVPYKMVKGYSNRARKARLAEPHLQDHNDLGLFGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPCMMPIGCVQLRLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPITDGYIVCEEFRDVLLAAWENEQALAEKK EKEKREKRALGNWKLLVRGLLIRERLKLRY----------GAKSEVVAPH---------- ---------------------------MD------GEGGLSSD-EE------EGT----- ------------SSQA-ETARILAASWPQNRE--------------------AE-E-EE- ------QKPK-CHR---TSRRG-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKAVAAHLFPFEK-L >ENSDNOP00000013987 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---MGRRGAASAVSRR-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------REP-RGQKAKGESQARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EEKEA--------------------- -------------------DVL-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------RKSLPSKVSQRKR-KK---------- ------------------------------------------------------------ -----------GCSDPGGPADGPAKKKVA-KVTVKSAKPNVIKEEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EDF----------- -------------------RSFSSIPKKACHTKRENSI---------------------- -------------------------DKGSSEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VPGDVGESATL---- ---------S-RSVVPVNP----VEIEIETPEQAKTRERS-------------EKIKMEF ETYLRRIMKRFNKEVHEGTHKVHLLCLLANGFYRNRVCSQPGLHAIALSIIPTHFT---- --KVLPRDMDIAYLSNLLKW----------FIGTFTVNADISVNEQD-----SLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLSRLVLSLQPIPLKLP A--------------------------------------TK------------------- ------------------------------------------------GK-KP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------E------------------------- ------------------------------------------------------------ -------------ERPTEVPG---GSSEVSSQVPENQTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK GTKQEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFS---------------------KGTGHPRTKGKRGKATTG--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------RKQRREPSSS-EDEDEGGQQEE------------------ --------------------------------SSQRRRH--------------G------ -----------------------------------------------------------R Q-----------------------------------------RRVASTVSYKEDSGS--- ----------------------------------------------------------DK AD-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----LSSGE--AHSLSDDNFE-------------------------SDLPRQRRALAPPG TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------ASKSDSR TRRKSHTKQPGSQAA-------PSSSSSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----SK--------------------------------- -----------------------------------NFSSNG------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------A------ERGK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------GKDQWLEVFCEQEERWVCVDCVH-GVVGQPLTCYKYATKPITYV VGIDSDGCARDITQRYDPAWMTATRKGRVNAEWWAETLRPYQSPFVEREKKEELEF-QAK HLEQPLPTAIGIYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYSRDRDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARKARLAEPQLRDQNDLGLFGLWQTEEYQPPMA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLKLPSIN RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEFKDVLLAAWENEQALIEKK EKEKREKRALGNWKLLVKGLLIRERLKLRY----------GAKSEATAPH---------- ---------------------------AS------AGGGLSSD-EE------EGT----- ------------SSQV-ETARILAASWPQNRE--------------------A--E-EE- ------PKPK-CPR---KTKRG-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKEAASHLFPFEK-L >ENSOPRP00000002823 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------V-------------------------------------------------- ------------RRRASRKEPQVPEPTRGSKAKGKSAARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GKQE---- ------------------------------------------------------------ -------------------DDF-------------------------------------- -------------EDEEPKP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KRSLPSPAPRGNR-KR---------- ------------------------------------------------------------ -----------GRSGARATAGGPAKKKAVDTVTVKSERLQAVKAEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ----------------------------------------------DDF----------- -------------------RD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------CPSDPGKVRRPGRGVPSGK------------------------- ---------------------------------GSDKD---------------------- -----DE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------VLGDVGEQPAA---- ---------S-RSRVPADT----VEIEIETPEQAKIRERS-------------EKMKMEF ETYVRRALKRFHKEVQENKHKVHLLCLLANGFYRNRVCSQPDLHAIGLSIIPARFT---- --RVPPGDVDVLYLSNLMK-----------FVGTFTVNTELSASEQD-----SLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPVPLKLS G--------------------------------------AK------------------- ------------------------------------------------GG-KS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SR------------------------- ------------------------------------------------------------ -------------KRSTEGPG---GATETSS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----PTPETSSKLRTNTTATAEEASLKGSSKPGTKGKRGK------------------- ------------------------------------AAAGRRKRQET------------- ---------------------SSSEEE--------------------------------- ------------------------------------------------------------ ---------------------------------------VGPGPKQGGRRKPQG------ -----------------------------------------------------------R Q-----------------------------------------RRVASRVSYKEDSGS--- ----------------------------------------------------------DG SS-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----PSSG---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ESQQPSDDSSGPGRIRPRKALAHRRA KAGPKPGVRTQGGGRRKHPALPGASPSSSGGTGSKKTSGDTKGKERGPLA---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEAKWVCVDCVH-GVVGQPLTCYRFATKPLRYV VGIDNEGWARDVTQRYDPAWMTETHKCRVDAEWWAETLRPYRSPLLEREKKEDAEF-QAK QLDQPLPTSIGIYKNHPLYALKRHLLKFQAIYPESAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGFSNRARKARLAEPQLHNQNDLGLFGRWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVHLNLPNLH RVARKLDIDCVPAVT-----GFDFHGGYCHPVTDGYIVCEEFKDVLLAAWENEQALIEKK EKEKKRKRALGNWKLLTKDLLIRERLRLRY----------GPRSEVVAPR---------- ---------------------------SD------ARGGLSSD-EE------EGT----- ------------SAQA-EAARILAASWPQNRA--------------------A--E-EQ- ------QKPQ--GA---KSRRG-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKAAASHLFPFEK-P >ENSOCUP00000009532 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M---------------------HRKQKEACWFTAGRSGRRAERHQGAWPGTTPPRGR GQSRSSSAASRGL----------------------------------------------V RHARSESCPGKMVRKRAAGGEPQGRKA------------PQAREARGQKAKGKST----- ARREKPEG-V-------------------------------------------------- ------------S----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EDEEAKP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLPSRVSQGKR-KR---------- ------------------------------------------------------------ -----------GCGGAAGAADGPAKKKAA-TAAVRSENLTAVKEEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ----------------------------------------------DDF----------- -------------------RD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------CPSDLRKAQPPERRAPAGK------------------------- ---------------------------------GSDQG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP------------VLGDVGEPEAS---- ---------S-QSTVPVSA----VEIEIETPEQAKMREKR-------------EKIKMEY ETYIRRAMKRFHKEVHENTHKVHLLCLLANGFYRNSVCSQPDLHAIGLSIIPTRFT---- --KVPPGDVDVSYLSNLVKW----------FIGTFTVNAELSASERD-----NLQTTLER RFAIYSARDDKELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPVPLKLS M--------------------------------------AK------------------- ------------------------------------------------GS-RS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------KRPTEDPG---GSSETSSQIAENHPK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------PKTSK AAKGEE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TFP---------------------KGTGRPGARGRRSK------------------- ------------------------------------AAAGSRQRAES------------- ---------------------SSSEEEGARKGKQKQ------------------------ ------------------------------------------------------------ --------------------------------ETPRRAR--------------G------ -----------------------------------------------------------R Q-----------------------------------------RRVASRVSYKEESGS--- ----------------------------------------------------------DG AD-----------------------------SS------------------SD------- --------------------------------------------------------FE-- ----PSSG--------DDDSE-------------------------PGPPRQRKTTAPQR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSK---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------CGPRTPSGGR SKHAGIPEASSSSAGGKGSKKLSRDSEEHERGGA-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEQEAKWVCVDCVH-GVVGQPLTCYRFATKPLSYV VGFDNEGWVRDVTQRYDPAWMTATRKCRVDAEWWAQTLRPYQSPFVERQKKEDSEF-QAK HLDQPLPTSIGTYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGFSNRARKARLAEPQLHDQNDLGLFGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLQ RVARKLDIDCVQAVT-----GFDFHGGYCHPVTEGYVVCEEFKDVLLAAWENEQALIEKK EKEKKEKRALGNWKLLAKGLLIRERLRLRY----------GAKSEAGAPR---------- ---------------------------SD------ARGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRA--------------------A--E-EE- ------QKPQ-CTK---KSKRG-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKAEASHLFPFEK-L >ENSFDAP00000022512 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAAGGR---------------------------------------- ------------------------------------------------------------ -------KPGDASVAR------------------RKKEK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EA--------------------- -------------------DVF-------------------------------------- -------------EDKKMKL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLRSKVSPGER-KR---------- ------------------------------------------------------------ -----------GFSDPGGPTDGPVKLKVA-KVTVKSEKLKAIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------G-------------- ------G---------------------------------------EDF----------- -------------------RDSSPDLKKAQRPKREAAV---------------------- -------------------------DKGSDEE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -E----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SGP------------APGDAGGSST----- ---------S-QSVLSLKP----VEIEIETPEQAKTREKS-------------EKIKMEF ETYLRRMMKRFSKEVQENTHKVHLLCLLANGFYRNGVCSQPDLLAIGLSIIPARFT---- --RVLPQDMDSGYLSSLVKW----------FIGTFTVNADLSAPNQS-----SLQTTLER RFAIYSARDEEELVH--------------------------------------------- ---------------------------------MFLLILRALQLLTRLVLSLQPLPLKSS M--------------------------------------AK------------------- ------------------------------------------------GK-KL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PK------------------------- ------------------------------------------------------------ -------------ERATEDPG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------DAPGTSSQAEENQPELQTSKG TR---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------EWET FPKGPSKA----------------------------------------------VTKGKR SRAAAGNMKQKESSSSKSKEAGPGKQQPQ---HRRAQRRAL------RVSYKEESES--- ----------------------------------------------------------DL AA-----------------------------SS------------------SD------- --------------------------------------------------------FE-- ----PSSGE--THHSSDESSE-------------------------PAPRRQKRARAPRR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSDSR TQPGSCHQHP-----------ASSCSLGS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KVSQDD------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------A------GGGR---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDHWLEVFCEKEAKWMCVDCVH-GVVDQPQACYRYATKPMTYV VGIDSDGWVRDVTQRYDPAWMTATRKCRVDAEWWDETLRPYQSPFVEREKKEDLEF-QAK HLDQPLPSAIGTYKNHPLYALKRHLLKYEAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARKARLADPQLQNQNDLGLFGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLHLPNLH RVARKLDIDCAPAVT-----GFDFHGGYCHAVTDGYVVCEEFRDVLLTAWENEQALIEKK EKERREKRALGNWKLLARGLLIREKLRMRY----------GAQSDAAAPH---------- ---------------------------MG------AGGGL-SD-DE------EGT----- ------------SSQA-EVASVLAASWPQNRE--------------------A--E-EE- ------QKPE-CPR---KTRKA-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKEAASHLFPFEK-L >ENSCPOP00000005994 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------S-------------------------------------------------- ------------RKRAA------------------------------------------- ------------------------------------------------------------ --------------------------------------RSH------------------- ------------------------------------------------------------ ----------KAKKASTAR----------------------------------------- ------------------------------------------------------------ ---------------------------------QEEEEA--------------------- -------------------DVF-------------------------------------- -------------EDKKVKL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLRSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GSSDAGGPVDGPVKKKVT-KVTVKSENLKAIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------E-------------- ------G---------------------------------------EDF----------- -------------------RDFSRDLKKAQRPKREAVT---------------------- -------------------------DNGGDEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SGP------------AQDDMGGSSA----- ---------S-QSVPPLKP----VEIEIETPEQVKTRERR-------------EKIKMEF ETHLRRMMKRFNKEVHENTHKVHLLCLLANGFYRNSVCSQPDLLAIGLSIVPARFT---- --KVPPEDVDLGYLSNLVKW----------FIGTFTVNADLSVPEQG-----NLQTTLEK RFAIYSARDEEELVH--------------------------------------------- ---------------------------------MFLLMLRALQLLTRLVLSLQPLPLKPS V--------------------------------------DK------------------- ------------------------------------------------RK-KL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PK------------------------- ------------------------------------------------------------ -------------DKATEDSG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------DAAGTSSQVPENQPTLQTSKG TRQGKAF----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------PKNKA--- ---------GTKGRRTATTGRTKHREPSSS------------------------------ ----------------------------------------------------EGEA---- ------------------------------------------------------------ --------------------AGPSKQQPQQLRHSRAQRRTP------RVSYKVESGS--- ----------------------------------------------------------DP AA-----------------------------SS------------------SD------- --------------------------------------------------------FE-- ----PSSEE--AHCSSDESSE-------------------------PAPPRQRRPSAPQL KKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKNDSR THPGSRRQHP-----------ASSSSLGN------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----SK--------------------------------- -----------------------------------KVSQDD------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------A-------GGK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEKEAKWLCVDCVH-GVVGQPRACYRYTTKPVTYV VGIDSNGWVRDVTQRYDPAWMTATRKCRVDAEWWDETLRPYQSPFVEREKKEDLEF-QAK HLDQPLPSAIGTYKNHPLYALKRHLLKYEAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARKARLANPQLQDQNDLGLFGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLHLPNLH RVARKLDIDCAPAVT-----GFDFHGGYCHAVTDGYVVCEEFRDVLLTAWENEQALIEKK EKEKREKRALGNWKLLARGLLIRERLRLRY----------GAQSDTSASH---------- ---------------------------TG------TGDGL-SD-EE------EGT----- ------------SSQA-EAARILAASWPQNRE--------------------G--E-EE- ------QKLK-CPR---RTRKA-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKEAAGHLFPFEK-L >ENSCLAP00000019528 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SGP------------APGDAGGTSA----- ---------S-QSVLPLKP----VEIEIETPEQVKTRERR-------------EKIKIEF ETYLRRMMKRFSKEVRENTHKVHLLCLLANGFYRNSVCRQPDLLAIGLSIVPARFT---- --RVPPQDVDSGFLSSLVKW----------FIGTFTVNADLSVPEQA-----GLQTTLER RFAIYSARDEEELVH--------------------------------------------- ---------------------------------MFLLILRALQLLTRLVLSLQPLPLKSS L--------------------------------------AK------------------- ------------------------------------------------VR-KL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PK------------------------- ------------------------------------------------------------ -------------DRATKDPG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------DAPGTSSETPESQPELQTSKG IRQGKAFSRGPDKAGT-------------------------------------------- ------------------------------------------------------------ -----------------------------------KGKRRK------------------- ------------------------------------------------------------ ----------------------------------------------TAAGSR-------- ----------------------KHGEPSSS------------------------------ ----------------------------------------------------EGEA---- ------------------------------------------------------------ --------------------AGPSEQQPQQPRRGRAQRRAL------RVSYKEDSGS--- ----------------------------------------------------------NS AA-----------------------------SS------------------SD------- --------------------------------------------------------FV-- ----PSSGE--AHQSSEEGSE-------------------------PAPPRPRRTRAPQC TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKSDSK TQPGSRRQRS-----------ASCSSLGS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KASQDD------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------A-------GGK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GIDQWLEVFCEKEAKWICVDCVH-GVVGQPRACYRYATKPMTYV LGIDSNGWVRDVTQRYDPAWMTATRKCRVDAEWWDETLRPYRSPFVEREKKEDLEF-QAK HLDQPLPSAIGTYKNHPLYALKRHLLKYEAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGFSNRARKARLADPQLQDQNDLGLFGRWQTEEYQPPLA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLHLPNLH RVARKLNIDCAPAVT-----GFDFHGGYCHAVTDGYVVCEEFRDVLLTAWENEQALIEKK EKEKREKRALGNWKLLARGLLIREKLQRRY----------GAQSDAAAPH---------- ---------------------------TA------GGGGL-SD-DE------EGT----- ------------SSQA-EAARVLAASWPQNRE--------------------A--E-EE- ------QKLK-CPR---KTRRA-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKEAAGHLFPFEK-L >ENSODEP00000002175 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---K-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------PVALQ--- -------TQDNELVRDVVGKRSWNVFEDKKIRHRKKSLRSKVSQGKR-KR---------- ------------------------------------------------------------ -----------GSGDPGGPVDGPVKKKVT-KVTVKSENLKVIKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------G---------------------------------------EDL----------- -------------------RDFSHDLKKAQRPKREVAV---------------------- -------------------------DKGHDEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D----EE-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SGT------------LPDDAGESSA----- ---------S-QSVLPLKP----VEIEIETPEQAKTRERR-------------EKIKMEF ESCLRRMMKRFSKEVHENTHKVHLLCLLANGFYRNAVCSQPDLLAIGLSIVPARFT---- --RVPPQDVDLSYLCNLVKW----------FIGTFTVNADLSVPEQG-----SLQTTLER RFAIYSARDEEELVH--------------------------------------------- ---------------------------------MFLLILRALQLLTRLVLSLQPLPLKSS V----------------------------------------------------------- ---------------------------------------------------KL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PK------------------------- ------------------------------------------------------------ -------------SKTTEDSG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------DAPGTSSQAAENQPERQTSKR TMQGKAFLKGPGKADT-------------------------------------------- ------------------------------------------------------------ -----------------------------------KGKRRK------------------- ------------------------------------------------------------ ----------------------------------------------TATGSM-------- ----------------------KQREPSSS------------------------------ ----------------------------------------------------EGEV---- ------------------------------------------------------------ --------------------AGPREQ----PRRSRARYRAH------RVSYKEESGS--- ----------------------------------------------------------DP AA-----------------------------SS------------------SD------- --------------------------------------------------------FE-- ----PSSEE--AHFSSDEGSE-------------------------PAPPRQKR------ --APN------------------------------------------LQW---------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------TK----- ------------------------------------------------------------ ----------------------------------------------------VGSKKDSR TRPRSRRQHP-----------ASSTSLGS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------KVSQDN------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------A-------GGK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEKDAKWMCVDCVH-GVVDQPRACYRYTTKPVTYV VGIDNNGWVRDVTQRYDPAWMTATRKCRVDAEWWDETLRPYRSPFVEREKKEDLEF-QAK HLDQPLPSAIGTYKNHPLYALKRHLLKYEAIYPETAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARKARLANPQLQDQNDLGLFGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLHLPNLH RVARKLDIDCAPAVT-----GFDFHGGYCHAVTDGYVVCEEFRDVLLTAWENEQALIEKK EKEKREKRALGNWKLLARGLLIRERLQLRY----------GAQSDAAAPH---------- ---------------------------TG------MGGGL-SD-EE------EGT----- ------------SSQA-EAARVLAASWPQNRE--------------------V--E-EE- ------QKPA-CPR---KTRRA-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKEAASHLFPFEK-- >ENSSSCP00000041133 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------PKRSAGRAPRGRKL-RGQKAKGEGKARR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EEKEA--------------------- -------------------DVS-------------------------------------- -------------EDE--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------L------- ----------------------------------KKSLLSKVSRGKR-KS---------- ------------------------------------------------------------ -----------SCGASGGPAAGPARKKVA-RATVKLETPQVVKDEAL------------- ----------------------------------------------S------------- ------------------------------------------------------------ ---------------------------------------------D-------------- ------E---------------------------------------DDF----------- -------------------RDFTSARKKTHLPKKEAAV---------------------- -------------------------DTGACEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -A----EE-------------DSED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP------------VPGGLGENTAF---- ---------S-KSAVPVKP----VEIEIETPEQVKARERS-------------EKIKMEF ETQLRRMMKRFNKEVHEDTHKVHLLCLLANGFYRNSICSQPDLRAIGLSIIPTRFT---- --KVPPQDVDVCYLSNLVKW----------FIGTFTVNADLSTNEQD-----GLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLIIRALHLSARLVLSLQPIPLKSS A--------------------------------------AK------------------- ------------------------------------------------GK-KA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERSTEGPG---CSSETSSPGPAKQTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LKSSS GNRREDPSS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EGTSGPRAKGKGSKAAAA--------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------TKKQREPSSSGEEEGKAAGQQG------------------ --------------------------------EARRPAR--------------G------ -----------------------------------------------------------R R-----------------------------------------RQAATRVSYKEESGS--- ----------------------------------------------------------DK AS-----------------------------SS------------------SD------- --------------------------------------------------------FE-- ----LSSGD--SHCPSDEDSE-------------------------PGLRRQRRAPGLPR TKA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GAKSDSR SQRGSHPKPPGFLAA-------SAGPPGS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------RK--GGK--------------------------------- -----------------------------------KTSVRG------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------A------DGGK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDHWLEVFCEREDKWVCVDCVH-GVVGQPLTCYQYATKPMTYV VGIDGDGWVRDVTQRYDPAWMTATRKCRVDAVWWAETLRPYRSPLLEREQREDQEF-QAK HLDQPMPTVIGTYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQGRVVRLGEVPYKMVKGYSNRARKARLAEPQLRDHNDLPLFGQWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPVGCVQLNLPNLQ RVARKLNIDCVQAIT-----GFDFHKGYSHPITDGYIVCEEYRDILLAAWENEQALIEKK EKEKKEKRTLGNWKLLVKGLLIRERLRLRY----------GTQ----------------- ------------------------------------------------------------ ----------------------------------VSVVLVGSLSALSQ------------ -----------CPR-------------PVSPTPCVLSSLGKFPRIGPHRLKSTPTGVRFG ILQSPGLLMPRGACSTPLHSTCSPHGSHQGTEASGRGYMEGPVLSQGCGDVLLGQLSPHC SVPPLPSHALPLLLAPPPSAVTPASRVPPALSWF------------------------ >ENSUPAP00010001071 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------IVGSYWPFGTGRSFLLGEELGPARRGAARPRPAWGRAPRARLFWGVLV RHALGEICPGSM------------------------------------------------ ---------A-------------------------------------------------- ------------RRRGARGEPRGREP-SGRSARGKNAAPR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------E E-------AAGVSEDKKPED---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKSLVPRVSPGKK-KR---------- ------------------------------------------------------------ -----------GRSRPGDSADRPARKKVA-RATVTSE----------------------- ------------------------------------------------------------ ---------------------------------------------SVPV----------- ---------------------------------------KEEALGE-------------- ------GAEVRGCSRDVKKARV-------------------------------------- --------------------------------KKEAPV---------------------- -------------------------DSTSSEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------D----------------------------------------------------- ------------------------------------------------------------ -D----DE-------------ESEE-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------GPSVVGGGPASS--- --------AS-ASAVPVEP----VEIEIETPEQAKSRERR-------------EKMKMEF ETYLRRMMKRFSKEVHENTHKVHLLCLLANGFYRNSVCSQPDLLAIGLSIIPTRFT---- --KVPPRDVDVSFLSNLVKW----------FIGTFTVNPDLSTNEQD-----DLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALRLLTRLVLSLQPIPLKLS V--------------------------------------AK------------------- ------------------------------------------------GR-RL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------ERAAEGAG---HSSE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AGRRVPGD----------------PKT-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PKSSPRAGP EGASSKGPGQRAAKARKTKATRPGRKRGD------------------------------- ---------------------SSSEE------------------------------AEGS QGQRPGKAQG-------------------------------------------------- ------------------------------------RPR--------------G------ -----------------------------------------------------------R Q-----------------------------------------RRVTSRVSYKEDSGS--- ----------------------------------------------------------GR SS-----------------------------SS------------------SD------- --------------------------------------------------------FE-- ----LSSGE--AHGSSGEDSE-------------------------PGPLKRRKAPAPRR TKS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GPKSD-- ---------------HCQRPAASSASSSH------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------K----------------- ------------------------------------------------------------ -------------------------------------------------A---------A GEAAEAAEAAGRGPP--------------------------------------------- ----------------GVDQWLEVFCERESRWVCVDCVH-GVVGQPLACYRFATRPVAYV VGIDSDGWVRDVTQRYDPAWMTATRKCRVDPEWWAETLRPYQSPQLDRDKKEDSEF-QAK HLGQPLPTAIGTYKNHPLYALKRHLLKYEAIYPESAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGFSNRARKARQAEPQLQDHRDLALFGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAVT-----GFDFHGGYSHPVTEGYIVCEEFKDVLLTAWENEQALIEKR EKEKREKRALGHWKLLTKGLLIRERLKLRY----------GAQKEAVASP---------- ---------------------------AD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRG--------------------A--EAEE- ------QKPR-RP----QTRRG-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKAADAHLFPFEK-M >ENSMMMP00000013188 ----------------------------------PGSPLSCSGDSRGRKLQKSWPEAQRD PGKHKSRCRGVC------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EDKKPEA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ----------------------------------KKGLVPKVSPGKK-KR---------- ------------------------------------------------------------ -----------GRSHPGDSADRPARKKVA-QATVTSE----------------------- ------------------------------------------------------------ ---------------------------------------------SLLV----------- ---------------------------------------KEEALGE-------------- ------GEEVRGFSRDFKKARV-------------------------------------- --------------------------------KKEAPV---------------------- -------------------------DRTSSEG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------E----------------------------------------------------- ------------------------------------------------------------ -D----EE-------------DSEE-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP------------GPSDMGGGSAS---- ---------S-ASVVPVEP----VEIEIETPEQAKSRQRR-------------EKMKMEF ETHLRRMMKRFSKEVHENTHKVHLLCLLANGFYRNSVCSQPDLLAIGLSIIPTRFT---- --KVPPHDVDVSFLSNLVKW----------FIGTFTVNPDLSTNEQD-----DLQTTLER RFAIYSARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALRLLTRLVLSLQPIPLKLS V--------------------------------------AK------------------- ------------------------------------------------GR-RL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ -------------GTCAEGAG---DSSE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------AGSQVPGD----------------PKT-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PKSSPRAGP GGASSKGPGQRAAKARKTQAARPGRKRGD------------------------------- ---------------------SSSE--------------------------------EGS QGQRPGKAPG-------------------------------------------------- ------------------------------------RPR--------------G------ -----------------------------------------------------------R Q-----------------------------------------RRVTSRVSYKEDSGS--- ----------------------------------------------------------GR SS-----------------------------SS------------------SD------- --------------------------------------------------------FE-- ----LSSGE--AHGSSGEDSE-------------------------PGPPKRRKAPAPRK TKS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GPQSD-- ---------------HCKRPAASSVSSSR------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------K----------------- ------------------------------------------------------------ -------------------------------------------------A---------T GEAEEAAEAAGRGLP--------------------------------------------- ----------------GVDQWLEVFCERESRWVCVDCVH-GVVGQPPACYRFATRPVAYV VGIDSDGWVRDVTQRYDPAWMTATRKCRVDPEWWAETLRPYQSPQLERDKKEDSEF-QAK HLGQPLPTAIGTYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRLGEVPYKMVKGFSNRARKARLAEPQLQDHNDLALFGRWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPSMMPIGCVQLNLPNLH RVARKLDIDCVQAVT-----GFDFHGGYSHPVTEGYIVCEEFKDVLLTAWENEQALIEKR EKEKREKRALGHWKLLTKGLLIREKLKLRY----------GAQTEAVASP---------- ---------------------------AD------AGGGLSSD-EE------EGT----- ------------SSQA-EAARILAASWPQNRG--------------------A--EDEE- ------QKSR-RP----QTRRG-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKAAAAHLFPFEK-M >ENSMODP00000009034 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAS------------------------------------------- -----------------------------------------------------------C EEPRGQRRP--------------------------KKTRT-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------QEAEA--------------------- -------------------DVF-------------------------------------- -------------EDE--KPKNIRLLKVSGGKRKKSCDPNGPNQGVSRKSR--------V KAEATSKN---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PP------- ---------------RV------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KEEASSE-------------- ------GEE---------------FTTFTSTPKKIQLVT--------------------- ----------------------------------EASV---------------------- -------------------------KQESSEE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------N----------------------------------------------------- ------------------------------------------------------------ -D----ED-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------NES------------VPEEMGEITASLKPI LST--------------KP----VEIEIETPEQVKERERR-------------EKRQMEF ETYLRRMMKRFNKEVHEDTHKVHLLCLLANGFFRNHVCNEPDLQAISLSIIPAHFT---- --KVLPSKVDVPYLSNLVKW----------FIATFTVNAELSTDDRD-----SLQSTLAR RFAIYSARDNEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLTRLVLSLQPIPLKF- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PA------------TKSKKNSSLKSSESSSQL PS---------------------------------------QKSQTQI------------ ------------------------------------------------------------ -----------R-------------------------------------------SKTN- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ------QMAASSKKTEEGKKTEPQKAAVGRKKHTQSLPSKEEDMVIEEEGTQRPI----R E-----------------------------------------RRRTSKVSYKEESGS--- ----------------------------------------------------------GG SA-----------------------------SS------------------SD------- --------------------------------------------------------FQ-- ----LSSEN--DSQLSNEDSQ-------------------------LGPQRPRRPPLSQK TKA----------------------------------------------ASKSSRKKISS SA---------------------------------------------------------- -----------------------------------------------------KNKRVGS QPCTLLAASPEA---------------------------------------TGT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------IISSD-------------------- ----------------DEEE---------------------------------------- ------------------------------------------------------------ ---------E------EIGK---------------------------------------- ---------------------------------T-------------------------- -------------------------------------------------V---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEGADKWICLDCVH-GVVGQPLTCYKYATKPLSYI IGIDNDGYARDITQRYDPVWMTATRKCRVDSEWWAATMRPYQSPFGAREDKEEMEF-QAK LQAQPLPTAIGMYKNHPLYALKRHLLKYEAIYPESAAILGYCRGEAIYS--RDCVHTLHS KDTWLKQARVVRIGEIPYKMVKGYSNRARKARLADPQFRDQDDLALFGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFLPCMLPIGCVQLKLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYVVCEEHKEVLLAAWENEQALIEQK EKEKREKRALGHWKLLVKGLLIRERLKRRF----------GDKGEAAAAP---------- ---------------------------PE-------GEGFSSD--E------EGT----- ------------SSQA--AAKNLAASWPQNRE--------------------T--E-EQ- ------QKLK-GTR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KREEVKHLFPFEK-L >ENSVURP00010020583 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAS------------------------------------------- -----------------------------------------------------------C KEQPGQRPP--------------------------KKART-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------QEAKP--------------------- -------------------DVF-------------------------------------- -------------EDQ--KPKNTRV----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ---------------RVPS-------------------------GKR-KK---------- ------------------------------------------------------------ -----------RSSDPGGP----------------------------------------- ---------------------------------------------------RGGASKKAG VKSEKKSEKRPA------------------------------------V----------- ---------------------------------------KEEASSE-------------- ------GED---------------FVDFTSITKKIRPKT--------------------- ----------------------------------EASV---------------------- -------------------------KKDSSRE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------N----------------------------------------------------- ------------------------------------------------------------ -E----ED-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------KEP------------VPDE----------- --TGGTAASF-QSTLPAKP----VEIEIETPEQLKARERR-------------EKRQTEL ETYLRRMMKRFNKEVREDTHKVHLLCLLANGFFRNNTCNEPDLQAIGLSIIPAHFA---- --KVLPNKVDVPYLSNLVKW----------FIATFTVNAELSTDERD-----SLRSTLER RFAIYSAQDNEELVH--------------------------------------------- ---------------------------------IFLLILRSLQLLTRLVLSLQPIPLKLL A--------------------------------------AK------------------- ------------------------------------------------GK-KK------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SQ------------------------- ------------------------------------------------------------ -------------NSSLENPE---SCSEP------------------------------- PS---------------------------------------QKAQTQI------------ ------------------------------------------------------------ -----------R-------------------------------------------PKTS- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -T---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ------RAAASSKRAAEGKKPKSQKAAVGSKKHAQCSPSEEEDVVVEKKEAQRPV----R E-----------------------------------------SRRTSKVSYKEESGS--- ----------------------------------------------------------DG AE-----------------------------SS------------------SD------- --------------------------------------------------------FE-- ----LSGEN--DSHLSDEDSQ-------------------------PGTQRPRRSAPSQR TKA----------------------------------------------ASVGSRRRVST SA---------------------------------------------------------- -----------------------------------------------------KNKRNGS QPSILPGASPEA---------------------------------------LGT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------K----VK--------------------------------- -----------------------------------IISSD-------------------- ----------------EEEE---------------------------------------- ------------------------------------------------------------ ---------E------EIGK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------V---------- ------------------------------------------------------------ ----------------GVDQWLEVYCEGEDRWVCVDCVH-GVVGQPLTCYKYATKPLSYI IGIDNDGCARDITQRYDPAWMTATRKCRVDSEWWAETLRPYQSPFGARENKEEMEF-QAK LQSQPLPTAIGMYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKEARVVRIGEVPYKMVKGYSNRARKARLADPQYRDQDDLGLFGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFVPSMLPIGCVQLKLPNLH RVARKLGIDCVQAIT-----GFDFHCGYSHPVTDGYIVCEEYKDVLLAAWDNEQSLIEQK EKEKREKRVLGHWKLLVKGLLIRERLKLRF----------GDKGEVAAAT---------- ---------------------------SE------RGAGFSSD--E------EGT----- ------------SSQA--AAQDLAASWPQNRE--------------------T--E-EQ- ------QKLR-RTR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------RREEAKHLFPFEK-L >ENSSHAP00000001339 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRAA------------------------------------------- -----------------------------------------------------------C EEQVGPRRP--------------------------KKSRG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------REAELADQSVN--------------- -------------------NVF-------------------------------------- -------------EDE--KPKKIHV----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ---------------RIPG-------------------------GKR-KK---------- ------------------------------------------------------------ -----------RSSSPGGP----------------------------------------- ---------------------------------------------------SISASKKVG AKAKKKTENHPS------------------------------------V----------- ---------------------------------------KEEASSEEDFTNFKSVPKKEI PLKIEP------------------------------------------------------ ------------------------------------SV---------------------- -------------------------KKDSSEE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------N----------------------------------------------------- ------------------------------------------------------------ -D----ED-------------ESED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP------------GPDEVGETAAPFKPA L--------------PAEP----VEIEIETPEQAKARERR-------------EKRQMEF ETYLRRMMKRFNKEVREDTHKVHLLCLLANGFFRNTVCNEPDLQAIGLSIVPAPFT---- --KVLPNKVDESYLSKLVKW----------FIATFTVNAELSTDERD-----SLGSTLER RFAIYSAQNDEELVH--------------------------------------------- ---------------------------------IFLLILRSLQLLTRLVLSLQPIPLKLL A--------------------------------------AK------------------- ------------------------------------------------GK-KK------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SQ------------------------- ------------------------------------------------------------ -------------DSSLKNPR---SSSQS------------------------------- PS---------------------------------------QKIQTQT------------ ------------------------------------------------------------ -----------K-------------------------------------------AKTS- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -S---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ------QAVASCRRAAESKKSAPAKTAVGRKKPAQASPGE------EKEGAQRPV----R E-----------------------------------------QRRTPKVSYREESGS--- ----------------------------------------------------------DG AR-----------------------------SS------------------SDSEFSSKD DSGSSDEESRPGPRRTRRPPASQRRGVASGSSPPVRRQRPGRPASALLAAPPEACP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----GK--------------------------------- -----------------------------------IISSDE------------------- ---------------EEEEE---------------------------------------- ------------------------------------------------------------ ---------E------EVRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GVDQWLEVFCEGEDRWVCVDCVH-GVVGQPLACYKYATKPLCYV VGIDNGGCARDVTQRYDPAWMTATRKCRVDSEWWAETLRPYQGPSGARESKEELEF-QAK LESQPLPTSIGMYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRLGEVPYKMVKGYSNRARKARLADPQLRDQDDLGLFGHWQTEEYQPPVA VDGK--------------------------VPRNEFGNVYLFVPSMLPIGCVQLKLPNLH RVARKLGIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEYKEVLLAAWDNEQSLIEQK EKEKREKRVLGHWKLLVKGLLIRERLKLRF----------GDKGEAVAAT---------- ---------------------------SE------GGAEFSSD--E------EGT----- ------------SSQA--AAKNLAASWPQNRE--------------------T--E-EQ- ------QKLK-GTR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKEEAKHLFPFEK-L >ENSCPBP00000020190 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------G-------------------------------------------------- ------------KKRKG------------------------------------------- -----------------SL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------QQEAANKKVK GEPAAAATRAPQTHRQESEDDF-------------------------------------- -------------EEE--KP---------------------------------------- ---SMKKNLSKVSGGNNKKKRDCDTEVHSLPGRSSRQKGAKSVAKEENNIDVKNKGNRNK GEM--------------------------------------------------------- --------------------------------------------CSA------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------LPSP---------------------------------- ----------------------------------------------------S---QKEM TLKRQSTI--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DD ------------------------------------------------------------ ------------------------------------------------------------ -----DD----------------------------------------------------- ------------------------------------------------------------ -D----GD-------------GSED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------EDP------------VLDKSGEAAAL---- ---------P-ALMLPSKP----VEIEIETPEQAKKRERR-------------EKRKAEF ETYLRRMMKRFNKEVHEDTHKVHLLCLLANGFYRNKVCNQPDLQAIGLSIIPTHFT---- --KVPAGRVDLLYLSNLVKW----------FVATFTINTELSVDDRE-----SLQSTLER RFAIYAARDDEELVH--------------------------------------------- ---------------------------------MFLLILRALQLLCRLVLSLRPIPLKEP A--------------------------------------GK------------------- ------------------------------------------------GK-SS------- ------------------------------------------------------------ ------------------CKKHSA------------------------------------ ------------------KNPKAPSRKSSCKGAKQQETVSGSEGADKE------------ -----------------SNTSGTKRKSKSKVIKDC------------------------- ------------------------------------------------------------ ---------------------------QEQ------------------------------ ---KESSDDESNLGEEEGA----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------HR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------------------------------------------------NN----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C R-----------------------------------------RRVTLKVSYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SD------------------SE------- --------------------------------------------------------FE-- ----ASEEE--DSHFSDEDFE-------------------------TVSKKQKRSSGPHK ----ARIAVENSRKTRSLDSKGPKNSGGNEQLLAKAASPGSSNTPR-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDD------------------- ----------------DG-E---------------------------------------- ------------------------------------------------------------ ---------Q------EVVK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------GTDQWLEIFVEREDRWVCVDCVR-GIVGQPSMCFKYATKPVSYI VGIDSNGHVKDVTQRYDPAWMTSTRKCRVDPQWWEDTLEPYRSPFVEREKKEEREF-LVK LQDQPLPTAIGEYKNHPLYALKRHILKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRIGEVPYKMVKGYSNQARKARLAEPSNREKDDLGLFGLWQTEEYQPPVA VDGR--------------------------VPRNEYGNVYLFLPCMLPIGCVQLKLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEYKEVLIAAWENEQAEIEKR EKEKREKRALGNWKLLAKGLLIRERLKQRY----------CRKSEASGSM---------- ---------------------------ME------KGAGFSSD-EE------GEP----- ------------SSET--PAEDVVVSWPQNRQ--------------------V--D-EQ- ------RKEK-KGR---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEVAHLFPFEK-L >ENSGAGP00000036274 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------G-------------------------------------------------- ------------RKRKG------------------------------------------- -----------------SL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------QRKAASKKFK GEPAATATRAPQTHRREAEDDF-------------------------------------- -------------EEE--KP---------------------------------------- ---SMKKNLSKVPSGNNKKKGDRDAEVHSPPGRSSRQKGAKSVAKEENNIAVKNKGNHNK GEM--------------------------------------------------------- --------------------------------------------CSA------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------LSSS---------------------------------- ----------------------------------------------------S---QKEM TLKRQSTI--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------N-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED ------------------------------------------------------------ ------------------------------------------------------------ -----DD----------------------------------------------------- ------------------------------------------------------------ -------D-------------GSED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------EDP------------VLDKSGEAAAL---- ---------P-ALVLPSKP----VEIEIETPEQAKKRERR-------------EKRKAEF ETYLRRMMKRFNKEVHEDTHKVHLLCLLANGFHRNSVCNQPDLQAIGLSVIPTRFT---- --KVPAGRIDVLYLSNLVKW----------FVATFTINTELSIDDRE-----SLQSTLER RFAIYAARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLCRLVLSLRPIPLKEP A--------------------------------------GK------------------- ------------------------------------------------GK-NS------- ------------------------------------------------------------ ------------------CKKHSA------------------------------------ ------------------KKPKAPSRKSSCKAAK-QETLSGSEGDCKE------------ -----------------SNTSGTKRKSKSKVIKDC------------------------- ------------------------------------------------------------ ---------------------------QEQ------------------------------ ---KESSDDESNPGEEERA----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------HM-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------------------------------------------------NN----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C P-----------------------------------------RRVTLKVSYKEESGS--- ----------------------------------------------------------DK -G-----------------------------SD------------------SD------- --------------------------------------------------------FE-- ----ASEEE--DSHFSDEDFE-------------------------TVSKKQRRSSGPHK ----ARIAVENSRKTRSLESKGPKKSGGNEQLLSKAASPGSSNTPR-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDD------------------- ----------------DE-E---------------------------------------- ------------------------------------------------------------ ---------Q------EVVK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------GTDQWLEIFVEREDRWVCVDCVR-GIVGQPSLCFRYATKPVSYI VGIDSNGHVKDITQRYDPAWMTSTRKCRVDPQWWEDTLEPYRSPFVEREKKEEREF-LAK LQDQPLPTAIGEYKNHPLYALKRHILKYEAIYPETAAIIGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRIGEVPYKMVKGYSNQARKARLAEPSNREKKDLGLFGLWQTEEYQPPVA VDGR--------------------------VPRNEYGNVYLFLPCMLPIGCVQLKLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEYKEVLIAAWENEQAEIEKR EKEKREKRALGNWKLLAKGLLIRERLKQRY----------CRKSEASSSM---------- ---------------------------LE------KGAGFSSD-EE------GKP----- ------------SAET--PAEDVVVSWPQNRQ--------------------V--D-EE- ------RKEK-KGR---RSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGEVAHLFPFEK-L >ENSCABP00000006144 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----MKKNLSKVPDGNNKKKGDHDTEGHSPPGRSSRQKGAKSVVKEENNIAVKNKGNHNK GEMSID-----------------------------SMGINFN------------------ ------------------------------------F----TFP---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------EDP------------VLGKSGEAAAL---- ---------P-ALVLPSKP----VEIEIETPEQAKKRQRR-------------EKRKAEF ETYLRRMMKRFNKEVHEDTHKVHLLCLLANVFHRNRVCNQPDLQAIGLSVIPTHFT---- --KVPAGRIDVLYLSKLVKW----------FFATFTINTELSIDDRE-----NLQSTLER RFAIYAARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLCRLVLSLRPIPLKEP A--------------------------------------GK-VGFTGIV----------- ---------------------------------------EEKELTILGGK-SS------- ------------------------------------------------------------ ------------------CMKYSA------------------------------------ ------------------KKPKAPSRKSSCKAAKQQETLSGSEGDCKE------------ -----------------SNTSGTKRKSKSKVIKDC------------------------- ------------------------------------------------------------ ---------------------------QEQ------------------------------ ---KESSDDESNLEEEGRA----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------HM-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C R-----------------------------------------RRVTLKVSYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SN------------------SE------- --------------------------------------------------------FE-- ----ASEEE--DSHFSDEDFE-------------------------TVSKKQRRSSGPYK ----ARIAIENSRKPRSLESKGPKKSGGNEQLLSKAASPGSSNTPR-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDD------------------- ----------------DE-E---------------------------------------- ------------------------------------------------------------ ---------Q------EVVK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------GTDQWLEIFVEREDRWVCVDCVR-GIVDQPSLCFKYATKPISYI VGIDSNGHVKDVTQRYDPAWMTLTRKCRVDPQWWEDTLEPYRSPFVEREKKEEKEF-LVK LQDQPLPTAIGEYKNHPLYALKRHILKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRIGEVPYKMVIGYSNQARKARLAEPSNREKKDLGLFGLWQTEEYQPPVA VDGR--------------------------VPRNEYGNVYLFLPSMLPIGCVQLKLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEYKEVLIAAWENEQAEIEKR EKEKREKRALGNWKLLAKGLVIRERLKQRY----------YRKSEASGSM---------- ---------------------------IE------KGAGFSSD-EE------GKP----- ------------SSET--PAEDVVVSWPQNRQ--------------------V--D-EQ- ------RKEK-KGR---RSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGEEAHLFPFEK-L >ENSPSIP00000017183 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KKRKG------------------------------------------- -----------------SL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------QQEASSKKFK AEPAAAATRALQTLRQEGEDNF-------------------------------------- -------------EGE--KP---------------------------------------- ---SLKKCLSKVPAGNKKKKKDCDTGIHRLPGRSSRQKGAKSTVKEENNIAVKNEGNL-K EEM--------------------------------------------------------- --------------------------------------------CSA------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------LPSS---------------------------------- ----------------------------------------------------P---QKEM TLKRKSAI--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EI---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------DD E----------------------------------------------------------- ------------------------------------------------------------ -----DD----------------------------------------------------- ------------------------------------------------------------ -D----GD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------E----------------EKSGEAAAL---- ---------P-ALVLPSKP----VEIEIETPELAKKRERR-------------EKRKAEF ETYLRRMMKRFNKEVHEDTHKVHLLCLLANGFHRNRVCNQPDLQAIGLSIIPTHFT---- --KVPAGRVDLLYLSNLVKW----------FVATFTINTELSVDDRE-----SLQSTLER RFAIYAARDDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLMCRLVLSLQPIPLKQP A--------------------------------------GK------------------- ------------------------------------------------GK-SS------- ------------------------------------------------------------ ------------------LKKHSA------------------------------------ ------------------KTPKAPSRKSSCKQAK-QEEMSGSEG---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ADRKGNVSVTKRSSKSK------------------------- ------------------------------------------------------------ VVK-------GGQE---------------------------------------------- --------------------------------------------QKETS--DGESYL--- -----------------------------------------------------------E EE-----VGTHR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------C R-----------------------------------------RRATVKVSYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SD------------------SE------- --------------------------------------------------------FE-- ----ASDEE--DSHFSDEDFE-------------------------TVCKKQKRSSGPHK ----ARLAVENSRKAKSLESKEFKNSGGNEQLLAKAASPGSSNKPK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDD------------------- ----------------DDGE---------------------------------------- ------------------------------------------------------------ ---------Q------EAVK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------GTDQWLEIFVEREDRWVCVDCVH-GIVDQPSLCFKYATKPVSYI VGIDTNGHVKDITQRYDPAWMTSTRKYRVDPQWWEDTLELYRSPFVEREKKEDREF-LVK LQDRPLPTSIGEYKNHPLYALKRHILKYEAIYPETAAILGYCRGEAVYA--RDCVHTLHS RDTWLKQARVVRIGEVPYKMVKGFSNQARKARMAEPSNREKEDLALFGLWQTEEYQPPVA VDGR--------------------------VPRNEYGNVYLFQPCMLPIGCVQLKLPNLH RVARKLDIDCVQAIT-----GFDFHGGYSHPVTDGYIVCEEYREVLIAAWENEQAELEKR EKEKREKRALGNWKLLAKGLLIRERLKQRY----------CKKSEASGSI---------- ---------------------------ME------NGAGFSSD-EE------GEP----- ------------SSKT--PAEDVIVSWPQNRQ--------------------V--E-EP- ------RKEK-KGR---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEAAHLFPFEK-L >ENSSPUP00000022183 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------FP---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------HET------------TSDKLGEVSAL---- ---------P-ELMLPNKP----VEIEIETPEQAKKRERR-------------EKRKVEF ETYLRRMMKRFNKEVHEDTHKVHLLCLLANGFYRNRLCNQLDLQAIGLSVIPTHLT---- --KVPVGRVDRLYLSNLVKW----------FVATFTINGELSVEDGE-----SLQSTLER RFDVYAARDDKELVH--------------------------------------------- ---------------------------------IFLLILRALQLLCRLVLSLQPIPLKET T--------------------------------------GK------------------- ------------------------------------------------GK-SSK------ -----------------------------------------KC----------GS----- -----------IPEEQGG----SS------------------------------------ ------------------KKPKVPSRK--------------------------------- ----------------------------------CVGKKIT------------------- ------------------------------------------------------------ -----------------------QGAAQEETLPRSPQTGKKAGTSGTKKAACKSRASVGD WKPKESSGDESRPGEKEGA----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------PR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NN----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R Q-----------------------------------------RRVASKVSYKEESGS--- ----------------------------------------------------------EE -D-----------------------------SD------------------SE------- --------------------------------------------------------FE-- ----AS-EE--DSNISDEDFE-------------------------DSSRKQRRPSGTHK --------------------------------------------PRAA------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ASSSSSRKAVISLSKVLKNSDRAE--------------- --------------------------------------CSLG------------------ ---------------KTASP---------------------------------------- --------------------------------LSSNSI---------------------- -----------------------KK----------------------------------- --------------------S----NK--------------------------------- -----------------------------------IISS-D------------------- ----------------DE-E---------------------------------------- ------------------------------------------------------------ ---------Q------GVVK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------GMDQWLEVFIEREDKWVCVDCVH-GVVGQPQLCFKYAMKPVSYI IGIDNDGSIKDVTQRYDPAWMTSTRKCRVDAEWWEDTLEPFRSPFVEREKKEETEF-LVK LQEQPLPTAIGEYKNHPLYALKRHVLKYEAIYPETAAILGYCRGEAVYS--RDCVHTMHS KDTWLKQARVVRIGEVPYKMVKGYSNQARKARMAEPANRDKKDLPLFGLWQTEEYQPPVA VDGR--------------------------VPRNEFGNVYLFLPSMLPIGCVQLKLPNLH RVPRKLDIDCVQAIT-----GFDFHGGYSHPVTDGYVVCEEYKEVLIAAWENEEAEREKR EKEKREKRALANWKLLTKGLLIRERLKQRY----------CSKSETAGAV---------- ---------------------------TE------GGDGFSSD-DE------GGP----- ------------SSEI--PAGDMPVSWPQNRK-----------------------E-EQ- ------REEK-QTR---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEEKYLFPFEK-L >ENSARWP00000005717 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ADDFEEKKPSTRRNNSKVPARKKEEDCDTGVCSS ANKPSKQKGVKLLIKEENNKTTKSKGNHSKEEP------------VADKLEEVAVV---- ---------P-TAVLPSKP----VEIEIETPEQAKKRERR-------------EKRKAEF EVYLRRMMKRFNKEVREDTHKVHLLCLLANGFYRNRICSQPDLLAIGLSIIPTHFT---- --KVPAGRVDLLYLSNLVKW----------FVGTFTVNDELSIEKGE-----PLQSTLGR RFAIYAARDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSLQPIPLKET R--------------------------------------AKSLSL--------------- -----------------------------------------------QGK-GS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRQSLSSTSEGQESSATTPKAVAKKG FCR------------------KKSNTAQKKRPCKSKLTTKSQEQREPSNEDCSLGEKDMP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SV------------------SD------- --------------------------------------------------------FK-- ----ASEEE---SSLSDEDFE-------------------------TVPKKQRKS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LGSRKSKVTADKSLKTKTSELRL SKSSHEAEPRPAKSTATALPKAQRK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------ILSSDE------------------- ----------------DDGE---------------------------------------- ------------------------------------------------------------ ---------Q------ELRK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------DTDQWLEVFLEREDKWVCVDCVH-GNVGQPQLCFKYATKPLSYI VGVDNDGSVKDVTQRYDPVWMTATRKSRVDSEWWENTLQPYKTPFVERDRKEEREF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYEAIYPESAAILGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRLGEVPYKMVKGFSNQARKARLAEPANRDKEDLALFGLWQTEEFQPPVA VDGK--------------------------VPRNEYGNVYLFLPSMLPIGCVQIRLPNLN RVARKLDIDCAQAIS-----GFDFHGGYSHPVTDGYVVCEEYKEVLIAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRY----------RIKTEPSAPE---------- ---------------------------AE------KGAGFSSD-EE------GGP----- ------------SSET--AVGDVAISWPQNRQ--------------------X--E-RQ- ------KEKK-TTK---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEAAQLFPFEK-L >ENSAHAP00000012745 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MSS----- ------------------------------------------------------------ ---------------------FLLASEDDFEEKKPSTRRNNSKVPARKKEEDCDTGVCSS ANKPSKQKGVKLLIKEENNKTTKSKGNHSKEEP------------VADKLEEVAVV---- ---------P-TAVLPSKP----VEIEIETPEQAKKRERR-------------EKRKAEF EVYLRRMMKRFNKEVREDTHKVHLLCLLANGFYRNRICSQPDLLAIGLSIIPTHFT---- --KVPAGRVDLLYLSNLVKW----------FVGTFTVNDELSIEKGE-----PLQSTLGR RFAIYAARDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSLQPIPLKET R--------------------------------------AKSLSL--------------- -----------------------------------------------QGK-GS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRQSLSSTSEGQESSATTPKAVAKKG FCR------------------KKSNTAQKKRPCKSKLTTKSQEQREPSNEDCSLGEKDMP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SV------------------SD------- --------------------------------------------------------FK-- ----ASEEE---SSLSDEDFE-------------------------TVPKKQRKS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LGSRKSKVTADKSLKTKTSELRL SKSSHEAEPRPAKSTATALPKAQRK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------ILSSDE------------------- ----------------DDGE---------------------------------------- ------------------------------------------------------------ ---------Q------ELRK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------DTDQWLEVFLEREDKWVCVDCVH-GNVGQPQLCFKYATKPLSYI VGVDNDGSVKDVTQRYDPVWMTATRKSRVDSEWWENTLQPYKTPFVERDRKEEREF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYEAIYPESAAILGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRLGEVPYKMVKGFSNQARKARLAEPANRDKEDLALFGLWQTEEFQPPVA VDGK--------------------------VPRNEYGNVYLFLPSMLPIGCVQLRLPNLN RVARKLDIDCAQAIS-----GFDFHGGYSHPVTDGYVVCEEYKEVLIAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRY----------RIKTEPSAPE---------- ---------------------------AE------KGAGFSSD-EE------GGP----- ------------SSET--AVGDVAISWPQNRQ--------------------V--E-RQ- ------KEKK-TTK---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEAAQLFPFEK-L >ENSAOWP00000027510 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MSS----- ------------------------------------------------------------ ---------------------FLLASEDDFEEKKPSTRRNNSKVPARKKEEDCDTGVCSS ANKPSKQKRVKLLIKEENNKTTKSKGNHSKE-------------------AKFAVV---- ---------P-TAVLPSKP----VEIEIETPEQAKKRERR-------------EKRKAEF EVYLRRMMKRFNKEVREDTHKVHLLCLLANGFYRNRICSQPDLLAIGLSIIPTHFT---- --KVPAGRVDLLYLSNLVKW----------FVGTFTVNDELSIEKGE-----PLQSTLGR RFAIYAARDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSLQPIPLKET R--------------------------------------AK------------------- ------------------------------------------------GK-GS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRQSLSSTSEGQESSATTPKAVAKKG FCRKAKQDEKSSGSEEDNRKPKKSNTAQKKRPCKSKLTTKSQEQREPSNEDCSLGEKDMP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SV------------------SD------- --------------------------------------------------------FK-- ----ASEEE---SSLSAEDFE-------------------------TVPKKQRKS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LGSRKSKVTADKSLKTKTSELRL SKSSHEAEPRPAKSTATALPKAQRK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------ILSSDE------------------- ----------------DDGE---------------------------------------- ------------------------------------------------------------ ---------Q------ELRK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------DTDQWLEVFLEREDKWVCVDCVH-GNVGQPQLCFKYATKPLSYI VGVDNDGSVKDVTQRYDPVWMTATRKSRVDSEWWENTLQPYKTPFVERDRKEEREF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYEAIYPESAAILGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRLGEVPYKMVKGFSNQARKARLAEPANRDKEDLALFGLWQTEEFQPPVA VDGK--------------------------VPRNEYGNVYLFLPSMLPIGCVQLRLPNLN RVARKLDIDCAQAIS-----GFDFHGGYSHPVTDGYVVCEEYKEVLIAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRY----------RIKTEPSAPE---------- ---------------------------AE------KGAGFSSD-EE------GGP----- ------------SSET--AVGDVAISWPQNRQ--------------------V--E-RQ- ------KEKK-TTK---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEAAQLFPFEK-L >ENSDNVP00000003864 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I NLKRESPA--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED N----------------------------------------------------------- ------------------------------------------------------------ -----DD----------------------------------------------------- ------------------------------------------------------------ -D----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------VVDKLEEDAVV---- ---------P-AAVLPSKP----VEIEVETPEQAKKRERR-------------EKRKAEF EVYLRRMMKRFIKEVREDTHKVHLLCLLANGFYRNRICSQPDLLAIGLSIIPTHFT---- --KVPEGRVDLLYLSNLVKW----------FVGTFTVNDELSIDKGE-----PLQSTLER RFAIYAARDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSLQPVPLKET K--------------------------------------AK------------------- ------------------------------------------------GK-GS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRQSLSSTSEGQESSATTPKAVAKKG FCRKAQQDKKSSES-EDNKEPKKPNTAQTKRPYKSKLTTESQAQREPSNEDCSLGEKDMP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -R-----------------------------SV------------------SD------- --------------------------------------------------------FE-- ----ASEEE---SSLSEEDFE-------------------------TVRKKQRRS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LGSQKSKVTADKSLKTKTSELRL SKKSHEAEPRPAKGTATALPNAQRK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DDGE---------------------------------------- ------------------------------------------------------------ ---------Q------ELRK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------GTDQWLEVFLEREDKWVCVDCVH-GTVGQPQLCFKYATKPLSYI VGVDNDGSVKDVTQRYDPVWMTATRKSRVDSEWWKDTLKPYKSPFVERDKKEEREF-QVK LQDQPLPTAIGEYKNHPLYALRRHLLKYEAIYPESAAILGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRIGEVPYKMVKGFSNQARKARLAEPANRDKEDLALFGLWQTEEFQPPVA VDGK--------------------------VPRNEYGNVYLFLPSMLPIGCVQLRLPNLN RVARKLDIDCVQAIS-----GFDFHGGYSHPVTDGYIVCEEYKEVLVAAWENEQAKIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRY----------CIKTEPSAPE---------- ---------------------------AE------KGAGFSSD-EE------GGP----- ------------SSET--AVGDVAISWPQNRQ--------------------V--E-RQ- ------KEEK-TTR---RSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEAAQLFPFEK-L >ENSCPUP00000029641 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRKA------------------------------------------- -----------------S------------------------------------------ -----------------------------PRPAAASKRRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGL--------GT-------PGDK--------- ---------------PEEDDDF-------------------------------------- -------------EEE--KP---------------------------------------- ---SIKKN---------------------------------------------------- -----------------------------------------NSKALARKKEENCDTRVSN ------------------------------SANK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------PSKQKGAKSLIKEEKKVTRNKGNHSKDETCSDLLKPP---Q-EI KLKKESPV--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED N----------------------------------------------------------- ----------------------------------TD------------------------ -----DD----------------------------------------------------- ------------------------------------------------------------ -D----EG-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------ATDKLEEAALL---- ---------P-AMGLPSNP----VEIEIETPEQMKRRQRR-------------EKRNAEF EMYLRRMMKRFSKDVRENTHKVHLLCLLANGFYRNRICSQPDLHAIGLSIIPIHFT---- --KVPAGQVDLPYLSNLVKW----------FVGTFTVNEELSTEKGE-----PLQSTLER RFAIYAARDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSFQPIPLKET K--------------------------------------AK------------------- ------------------------------------------------VK-SS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRQSL-STSEGQESSATTPKAVAKKC PCRKAKQDEKSSESEEDNKEPKKRKTAQTKRTRKSRLTPGSQEQKESGNEESGLAEKDVP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----VSEEE---SDLSDDDFE-------------------------TVSKRQRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LGSQKSKVTAIKSPKTETSESRL PKNSCGAEPRSAKSTAPALPPAQRK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DDGQ---------------------------------------- ------------------------------------------------------------ ---------Q------EVRK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------V---------- ------------------------------------------------------------ ----------------GTDQWLEVFLEREDKWVCVDCVH-GNVGQPQLCFTYATKPLSYI LGFDNDGSVRDVTQRYDPVWMTTTRKSRVDPEWWEDTLQPYKSPYVERDEKEENEF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYQAIYPETAAVLGYCRGEPVYS--RDCVHTLHS KDTWLKKARVVRIGEVPYKMVKGFSNQARKARLAEPANRDKEDLALFGRWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFLPSMLPVGCVQLRLPNLN RLARKLDIDCAQAIT-----GFDFHGGYSHPVTDGYVVCEEYKEVLIAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRY----------SIKTEPAAPD---------- ---------------------------AE------KGAGFSSD-EE------GGP----- ------------SSET--AVGNTDISWPQNRQ--------------------L--E-KK- ------KEEE-TTR---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEAAQLFPFEK-L >ENSAPLP00000014092 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------ALPLPSLP--------RPLPLRRGGLWGGQTRGPGVCGRC----------- --------SAMARKRKA------------------------------------------- -----------------SIPAATA------------------------------------ ----SKKRPGGP---RDEVKKEKE--EEEE------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------EEEDDF-------------------------------------- -------------EEK--KP---------------------------------------- ---SIKK----------------------------------------------------- ------------------------------------------------------------ --------------------------------NKPKV----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------PAT-------------------------------- KKKEDSDPGVSKSANKPSKQKGVKLLAKENKKITENKGNHSKEQTCSDSLKPP---QRET KLKRESSV--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED N----------------------------------------------------------- ----------------------------------T-DN---------------------- -----DD----------------------------------------------------- ------------------------------------------------------------ -D----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------VTDKLEEAAVH---- ---------S-SVALPSNP----VEIEIETPEQRKKRERR-------------EKRKSEF ETYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRNRICSQPDLHAIGLSIIPTRFT---- --KVSAGQVDVLYLSNFVKW----------FIGTFTVNDELSIEKGE-----PLQSTLER RFAIYAARDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSLQPVPLKET T--------------------------------------AK------------------- ------------------------------------------------GK-GS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRQSLSSTSEGRESSGTTPKAVAKKC PCKKAKKDEKSSGSEEDNKEPEKPRTARTKRTHKSKLTSGSQEQKEIGNEESGLGEKDVP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------K-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NN----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -D-----------------------------SA------------------SD------- --------------------------------------------------------FE-- ----VSEEE---SDLSDEDFV-------------------------TVSKKQRRS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LGSQKSKLTSIKSPKTETSESKQ SKNCSGVEPRPAKSTAPALPHAPRK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DDGQ---------------------------------------- ------------------------------------------------------------ ---------Q------LVRK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------I---------- ------------------------------------------------------------ ----------------GTDQWLEVYLEREDKWVCVDCVH-GSVGQPQQCFKYSTKPLYYV VGFDNDGSVKDVTQRYDPVWMTTTRKNRVDPEWWEDTLQPYRSPFVERDEKEEKEF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYQAIYPESAAILGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRIGEVPYKMVKGYSNQARKARLAEPANRDKEDLALFGRWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFLPSMLPVGCVQLRLPNLN RLARKLDIDCAQAIT-----GFDFHGGYSHPVTDGYVVCEEYKEVLIAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRY----------SIKTEPSAPE---------- ---------------------------TE------KGAGFSSD-EE------GGP----- ------------SSGT--AGRDVAISWPQNRQ--------------------V--E-KQ- ------KEEQ-TTK---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEAAQLFPFEK-L >ENSABRP00000011524 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KKRKA------------------------------------------- -----------------SISAAAA------------------------------------ ----SKKRPGGP---RAEVKKKKEEEEEEE------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------EEEDDF-------------------------------------- -------------EEK--QP---------------------------------------- ---SIKK----------------------------------------------------- ------------------------------------------------------------ --------------------------------NKPKV----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------PAT-------------------------------- KKKEDSDPGVSKSASKPSKQKGVKLLAKENKKITKNKGNHSKEQTCSDSLKPP---QRVT KLKRESPV--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED N----------------------------------------------------------- ----------------------------------TDDN---------------------- -----DD----------------------------------------------------- ------------------------------------------------------------ -N----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------VTGKLEEAAVL---- ---------S-SVALPSNP----VEIEIETAEQRKRRERG-------------EKRKAEF ETYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRNRICSQPDLHAIGLSIIPTHFT---- --KVPAGQVDILYLSNLVKW----------FIGTFTVNDELSTEKGE-----SLQSTLER RFAIYAARDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSLQPVPLKET T--------------------------------------AK------------------- ------------------------------------------------GK-GS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRQSLSSTSEGRESSGTTPKAVAKKC PCKKAKKDEKSSGSEEDDKEPKKPRTARTKRTHKSKLPSGSQEQKEISNEESGLGEKDVP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SV------------------SD------- --------------------------------------------------------FE-- ----ISEEE---SDLSDEDFE-------------------------TVSKKQRRS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LGSQKSKLTSIKSPKTETSESKQ SKNCSGVEPRPVKSTAPALPHAPRK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DDGQ---------------------------------------- ------------------------------------------------------------ ---------Q------VVRK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------V---------- ------------------------------------------------------------ ----------------GTDQWLEVFLEREDKWVCVDCVH-GSVGQPQQCFTYSTKPLYYI VGFDNDGSVKDVTQRYDPVWMTTTRKNRVDPEWWEDTLQPYRSPFVERDEKEEREF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYQAIYPESAAILGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRIGEVPYKMVKGYSNQARKARLAEPANRDKEDLALFGRWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFLPSMLPVGCVQLRLPNLN RLARKLDIDCAQAIT-----GFDFHGGYSHPVTDGYVVCEEYKDVLIAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRY----------SIKTEPSAPE---------- ---------------------------TE------KGAGFSSD-EE------GGP----- ------------SSGT--AGRDVAISWPQNRQ--------------------V--E-KQ- ------KEEQ-TTK---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEAAQLFPFEK-L >ENSMGAP00000007912 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRKA------------------------------------------- -----------------SVVRKPA------------------------------------ ----GKRRPGG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AGVRRDGEEEREEGDFVEEKPSVKKSRAGVAAK KKEDDGDAGVAKSADKPSKQ---KRRAKENEKSPENKGTRHKEQTCSDSPKAS---QKEI KLKRESLI--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED N----------------------------------------------------------- ----------------------------------T------------------------- -----DD----------------------------------------------------- ------------------------------------------------------------ -D----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------VVDKLEEGAVL---- ---------P-AVVLPSNP----VEIEIETPEQLKRRERR-------------EKRKAEF ETYVRRMIKRFTKEVREDTHKVHLLCLLANGFYRNRICSQPDLHAIGLSIIPIHFT---- --KVPAGQVDLLYISNLVKW----------FVGTFTVNDELSSEKGE-----PLQSTLER RFAIYAARDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSLQPIPLKET K--------------------------------------AK------------------- ------------------------------------------------EK-DT------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKKQSLSSTSEGQESSGTTPKVVAKKC PCKKAKRDEKSSGSEEDNEESKKTKSAQTKRTHKSKLTTGNKEQKETGNEDSGLGEKDVP I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SV------------------SD------- --------------------------------------------------------FE-- ----ISGEE---SDISDEDFE-------------------------TVSKKRRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RGAQKSKVMTMKSPKR------- ------VEPRPAKTAAPSLPRAQRK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DDGQ---------------------------------------- ------------------------------------------------------------ ---------Q------MVQK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------V---------- ------------------------------------------------------------ ----------------GTDQWLEVFLEREDRWVCVDCVH-GIVGQPQQCFTYATKPLSYI VGFDNDGSVKDVTQRYDPVWMTTTRKKRVDPEWWEDTLQPYKSPFADRDKKEETEF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYQAIYPESAAILGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRIGEVPYKMVKGYSNQARKARLAEPANRDKADLALFGRWQTEEYQPPIA VDGK-----------------------QYQVPRNEYGNVYLFLPSMLPVGCVQLRLPNLN RLARKLDIDCAQAVT-----GFDFHGGYSHAVTDGYVVCEEYKEVLIAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRF----------SIKAEPSAPE---------- ---------------------------TE------KGAGFSSD-EE-------GP----- ------------NSGT--AGGDMEIFWPRNRQ--------------------A--E-KQ- ------K-EK-TTR---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKDEAAQLFPFEK-L >ENSCJPP00005019947 ML---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -AAM-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRKA------------------------------------------- -----------------SVQRVSA------------------------------------ ----GKRRPGG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VGVRRDGAEEREEGDFVEEKHSVKKSRAGVAAR KKEEDSDAGIAKLAEKPSKQKGVKGRVKENERDPENKGDDHEEEKCSDSVKAP---QKEV KLKRESPI--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED N----------------------------------------------------------- ----------------------------------TD-D---------------------- -----DD----------------------------------------------------- ------------------------------------------------------------ -D----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------LVDKLEEGAVL---- ---------P-EVVLPSNP----VEIEIETPEQLMKRQRR-------------EKRKAEF ETYVRRMIKRFTKEVREDTHKVHLLCLLANGFYRNRICSQPDLHAIGLSIIPIHFT---- --KVPASQVDLLYISNLVKW----------FVGTFTVNDELSTEKGE-----PLQSTLER RFAIYAARDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSLQPIPLKET K--------------------------------------AK------------------- ------------------------------------------------EK-SK------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------FKKQSLSSTSEGQESSGTTPKVVAKKC PCKKAKRDEKSSGSEEDNEESKQTKSAETKRTHKSKLTTGNKEQKETGNEDSGLGEKDVP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NN----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SG------------------SD------- --------------------------------------------------------FE-- ----ISGEE---SDISDEDFE-------------------------TVSKKRRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RGAQKSKVMAIKSPKSETSESKL SRNTLGVEPRPAKSTAPTLPHTQKK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DDGQ---------------------------------------- ------------------------------------------------------------ ---------Q------MVQK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GTDQWLEVFLEREDRWVCVDCVH-GIVGQPQQCFAYATKPLSYV VGFDNDGSVKDVTQRYDPVWMTTTRKKRVDPEWWEDTLQPYRSPFVDRDKKEETEF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYQAIYPESAAILGYCRGEPVYS--RDCVHTLHS KDTWLKQARVVRIGEVPYKMVKGYSNQARKARLAEPANRDKADLALFGRWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFLPSMLPVGCVQLRLPNLN RLARKLDIDCAQAVT-----GFDFHGGYSHAVTDGYVVCEEYKEVLIAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRF----------SIKAEPSASE---------- ---------------------------TE------KGTGFSSD-EE-------GP----- ------------SSGT--AGGDVEVSWPRNRQ--------------------A--E-QQ- ------K-EK-TTR---KSKRQ-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKEEAAQLFPFEK-L >ENSGALP00000010261 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------M---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED N----------------------------------------------------------- ----------------------------------TD-D---------------------- -----DD----------------------------------------------------- ------------------------------------------------------------ -D----D--------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------ATDKLEQGAVL---- ---------P-AVVLPSNP----VEIEIETPEQLKKRERR-------------EKRKAEF ETYVRRMIKRFTKEVREDTHKVHLLCLLANGFYRNRICSQPDLHAIGLSIIPIHFT---- --KVPAGQVDLLYISNLVKW----------FVGTFTVNDELSTEKGE-----PLQSTLER RFAIYAARDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSLQPIPLKET K--------------------------------------AK------------------- ------------------------------------------------EK-ST------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKKQSLSSTSEGQESSGTTPKAVAKKC PCKKAKRDEKSSGSEEDNEESKKTKSAQTERTHKSKLTAGNREQKETRNVDSGLREKDVP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R W-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SV------------------SD------- --------------------------------------------------------FE-- ----ISGEE---SDISDEDFE-------------------------TVSKKRRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QGAQKSKVMTVKSPKSETSESRL SRNSLGVEPR---------PHAQRK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DDGQ---------------------------------------- ------------------------------------------------------------ ---------Q------MVRK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------V---------- ------------------------------------------------------------ ----------------GTDQWLEVFLEREDRWVCVDCVH-GIVGQPQQCFTYATKPLSYI VGFDNDGSVKDVTQRYDPVWMTMTRKKRVDPEWWEDTLQPYKSPFVDRDKKEETEF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYQAIYPESAAILGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRIGEVPYKMVKGYSNQARKARLAEPANRDKADLALFGRWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFLPSMLPIGCVQLRLPNLN RLARKLDIDCAQAVT-----GFDFHGGYSHAVTDGYVVCEEYKEVLIAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRY----------SIKVEPSAPE---------- ---------------------------TE------KGGGFSSD-EE-------GP----- ------------SSGT--AGGGMEIFWPRNRQ--------------------A--E-KQ- ------K-EK-ATR---KSKQE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKEEAAQLFPFEK-L >ENSNMEP00000023813 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRKA------------------------------------------- -----------------SLPRAAA------------------------------------ ----GKRRPGG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TGERRDGAEEREEDDFVEEKPSVKKSRLGVPAR KEEEDCDAGVSKSAHTPSKQKGVKRQAKENKKSTESKGTHHKEQTCSDSLKAP---QKET KLERDSPI--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED N----------------------------------------------------------- ----------------------------------TDGD---------------------- -----GD----------------------------------------------------- ------------------------------------------------------------ -D----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------VIDKLEEGAVL---- ---------P-AVELPSNP----VEIEIETPEQLKKRERR-------------EKRKAEF ETYLRRMIKRFTKEVREDTHKVHLLCLLANGFYRNRICSQPDLHAIGLSIIPIHFT---- --KVPARQVDLLYISNLVKW----------FVGTFTVNEELSTEKGE-----PLQSTLER RFAIYAARDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSLQPVPLKET K--------------------------------------AK------------------- ------------------------------------------------EK-ST------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKKQSLSSTSEGQESSGTTPKAEAKKC PCKKAQRDEKSSGSEEDNEESRKTKSAQTKRTRKSKLTTGNKEQKETRNEDGGLGGKDVP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NN----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DD -D-----------------------------SV------------------SD------- --------------------------------------------------------FE-- ----ISGEE---SDVSDEDFE-------------------------TVSKKRRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RGAQKSKVMTIKSPKSETSESRL SRNSNGVEPRSAKSTAPALPHGQRK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------EDGQ---------------------------------------- ------------------------------------------------------------ ---------Q------MVRK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------V---------- ------------------------------------------------------------ ----------------GTDQWLEVFLEREDKWVCVDCVH-GSVGQPQQCFTYATKPLSYI VGFDNDGSVKDVTQRYDPVWMTVTRKNRVDPEWWEDTLEPYKSPFVDRDKKEEKEF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYQAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRIGEVPYKMVKGYSNQARKARLAEPANRDKADLALFGRWQTEEFQPPIA VDGK--------------------------VPRNEYGNVYLFLPSMLPIGCVQLRLPNLN RLARKLDIDCAQAVT-----GFDFHGGYSHAVTDGYVVCEEYKEVLIAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRY----------SIKTEPSAPE---------- ---------------------------TE------KGAGFSDE-EG-------GP----- ------------SSGT--AGGDVEISWPRNRQ--------------------V--E-KQ- ------KEEK-TTR---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEAAELFPFEK-L >ENSMVIP00005025987 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRKA------------------------------------------- -----------------S------------------------------------------ -----------------------------PRPAAARKRRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGL-REEEE------------------------ -----------------EEDDF-------------------------------------- -------------EEE--KP---------------------------------------- ---STKK----------------------------------------------------- -----------------------------------------NSKAPARKKEEGCDNGVSN SAKTSK---QTGAKSQTKENKRNGRNKENCN----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KEEMCSDSPKPP---QKEM KLKKESPV--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------S-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED N----------------------------------------------------------- ----------------------------------TD-N---------------------- -----DD----------------------------------------------------- ------------------------------------------------------------ -D----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------ATDKFEEAAVL---- ---------P-AVGLPSKP----VEIEIETPEQMKKRERR-------------EKRKAEF EAYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRNRICSQPDLLAIGLSVIPTRFT---- --TVPAGKVDLIYLSNLVKW----------FIGTFTVNDELSTEKGE-----PLQSTLER RFAIYAAQDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSFQPIPLKDT R--------------------------------------PK------------------- ------------------------------------------------GR-SS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRQSLSNTSEGQESSATTPKAGAKKC PCKKAKQDEKSSESEEDIKEPKKAKTAQTKGAHKSKLAKGSQEQKESSNE-SSLAEKDVP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESES--- ----------------------------------------------------------DE -G-----------------------------SV------------------SD------- --------------------------------------------------------FE-- ----VSEEE---SDLSDEDFE-------------------------TVSKRRRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LASQKAKMTTLKSPKTETSESRL SKNSCGSEPKPAKSTAPALPAGQKK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DDGQ---------------------------------------- ------------------------------------------------------------ ---------Q------EVRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------GTDQWLEVFLNREDKWVCVDCVH-GNVGQPQLCFTHATKPLFYV VGFDNDGSVRDVTQRYDPVWMTATRKIRVDPEWWEETLQPYESPNVERDRKEETEF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYQAIYPESAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRIGEVPYKMVKGFSNQARKARLMEPANRDREDLALFGHWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFLPSMLPVGCVQLKLPNLN RVARKLNIDCVQAIT-----GFDFHGGYSHPVTDGYVVCEEYKDVLIAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIREKLKKRY----------SIKTEPSAPE---------- ---------------------------TE------KGAGFSSD-EE------GAP----- ------------SSES--AVGNVAISWPQNRQ--------------------L--EKKE- ------E-EK-KTR---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKGEEAQLFPFEK-L >ENSLCOP00000017173 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------G-------------------------------------------------- ------------RKRKA------------------------------------------- -----------------S------------------------------------------ -----------------------------PRPAAVRKRRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGL-REEEE------------------------ -----------------EEDDF-------------------------------------- -------------EEE--KP---------------------------------------- ---STKK----------------------------------------------------- -----------------------------------------NSKAPARKKEEGCDNGVSN SAKTSK---QTGAKSQTKENKRNGRNKENCN----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KEEMCSDSPKPP---QKEM KLKKESPV--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------S-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED N----------------------------------------------------------- ----------------------------------TD-N---------------------- -----DD----------------------------------------------------- ------------------------------------------------------------ -D----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------ATDKFEEAAVL---- ---------P-AVGLPSKP----VEIEIETPEQMKKRERR-------------EKRKAEF EAYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRNRICSQPDLLAIGLSVIPTRFT---- --TVPAGKVDLLYLSNLVKW----------FIGTFTVNDELFTEKGE-----PLQSTLER RFAIYAAQDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSFQPIPLKDT R--------------------------------------PK------------------- ------------------------------------------------GK-SS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRQSLSNTSERQESSATTPKAGAKKC PCKKAKQDEKSSESEEDIREPKKAKTAQTKGTHKSKLAKGSQEQKESSNE-SSLAEKDVP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESES--- ----------------------------------------------------------DE -G-----------------------------SV------------------SD------- --------------------------------------------------------FE-- ----VSEEE---SDLSDEDFE-------------------------TVSKRRRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LASQKAQMTTLKSPKTETSESRL SKNSCGSEPKPAKSTAPALPAGQKK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DDGQ---------------------------------------- ------------------------------------------------------------ ---------Q------ELRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------GTDQWLEVFLEREDKWVCVDCVH-GNVGQPQLCFTHATKPLFYI VGFDNDGSVRDVTQRYDPVWMTATRKIRVDPEWWEETLQPYESPNVERDKKEETEF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYQAIYPESAAILGYCRGEAVYS--RDCVHTLHS RDTWLKKARVVRIGEVPYKMVKGFSNQARKARLVEPANRDREDLALFGHWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFLPSMLPVGCVQLKLPNLN RVARKLNIDCVQAIT-----GFDFHGGYSHPVTDGYVVCEEYKEVLIAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIREKLKKRY----------SIKTEPSAPE---------- ---------------------------TE------KGAGFSSD-EE------GAP----- ------------SSES--AVGNAAISWPQNRQ--------------------L--EKKE- ------E-EK-KTR---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKGEEAQLFPFEK-L >ENSTGUP00000008572 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----ND----------------------------------------------------- ------------------------------------------------------------ -D----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------S-DKL-EATVL---- ---------P-SMGLPSNP----VEIEIETPEQVKKRETR-------------EKRKAEF EMYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRNRICSQPDLLAIALSIVPTRFT---- --QVPAGQVGLVYLSNLVKW----------FVGTFTVNDELSTEKGE-----PLQATLER RFAIYAAQDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSFQPIPLKET R--------------------------------------PK------------------- ------------------------------------------------AK-SS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRLSHSSTCEGRESSTTTPKAVAKTC PCKKAKQDEKSSESKENNKEPKKPKTAQTGRTHKSKLTKGSQEQKGSNNE-TSSAEKDVP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SA------------------SD------- --------------------------------------------------------FE-- ----VSEEE---SDLSDEDFE-------------------------TVPKRRRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QASQNSKLTTIKRSKTETSETRQ AENLHGAETKPAKT--------QRK----------------------------------- --------------------K----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DDGQ---------------------------------------- ------------------------------------------------------------ ---------Q------EVRR---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------M---------- ------------------------------------------------------------ ----------------GTDQWLEVFLEPEDKWVCVDCVH-GNVGQPQLCFAHATKPLFYV VGFDNDGSVRDVTQRYDPVWMTSTRKSRVDPEWWEETLQPYESPFVERDKKEENEF-QVK LQDQPLPTSIGEYKNHPLYALKRHLLKYQAIYPESAAILGYCRGEAVYS--RDCIHTLHS RDTWLKQARVVRIGEVPYKMVRGFSNRARKARLAEPAIRDREDLALFGRWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFLPSMLPVGCVQLKLPNLN RVARKLNIDCAQAIT-----GFDFHGGYSHPVTDGYVVCEEYKDVLVAAWENEQAEIEKK EKQKREVRALGNWKLLTKGLLIRERLKQRY----------SIKTEPSVPE---------- ---------------------------TE------KGGGFSSD-EE------GAP----- ------------SSES--TVGNTAIYWPQNRQ--------------------Q--E-KQ- ------E-EI-AAK---TSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGEAAQLFPFEK-L >ENSLSDP00000013431 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------M---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED N----------------------------------------------------------- ----------------------------------TD-N---------------------- -----ND----------------------------------------------------- ------------------------------------------------------------ -D----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------P-DKLEEATVL---- ---------P-SVGLPSNP----VEIEIETPEQVKKRERR-------------EKRKAEF EMYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRNRICSQPDLLAIALSIVPTRFT---- --QVPTGQVGLVYLSNLVKW----------FVGTFTVNDELSTEKGE-----PLQATLER RFAIYAAQDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSFQPIPLKET R--------------------------------------PK------------------- ------------------------------------------------AK-SS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRLSHSSTHEGRESSATTPKAVAKTC PCKKAKQDEKSSESKESNKEPKKPKTAQTGRTHKSKLTKGSQEQKGSNNE-TSSAEKDVP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SA------------------SD------- --------------------------------------------------------FE-- ----VSEEE---SDLSDEDFE-------------------------TVPKRRRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QASQNSKLTTVKRSKTETSETRQ AENSHGAETKPAKSTTPALPQAQRK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DDGQ---------------------------------------- ------------------------------------------------------------ ---------Q------EVRR---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------M---------- ------------------------------------------------------------ ----------------GTDQWLEVFLEPEDKWVCVDCVH-GNVGQPQLCFAHATKPLFYV VGFDNDGSVRDVTQRYDPVWMTSTRKSRVDAEWWEETLQPYESPYVERDKKEENEF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYQAIYPESAAILGYCRGEAVYS--RDCIHTLHS RDTWLKQARVVRIGEVPYKMVRGFSNRVRKARLAEPANRDQEDLALFGRWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFLPSMLPVGCVQLKLPNLN RVARKLDIDCAQAIT-----GFDFHGGYSHPVTDGYVVCEEYKEVLVAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLRQRY----------SIKTEPSAPE---------- ---------------------------TE------KGGGFSSD-EE------GAP----- ------------SSEN--TVGNTAIYWPQNRQ--------------------Q--E-KQ- ------E-EI-AAK---MSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGEAAQLFPFEK-L >ENSSCAP00000006339 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------ARPLP----LPLPSAAR--------------------GRAGP-----ARAG --------SAMARKRRA------------------------------------------- -----------------S------------------------------------------ -----------------------------PRPAAAKKRRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GRL-PKEEEEEE--------------------- ----------------EEKDDF-------------------------------------- -------------EEK--KP---------------------------------------- ---SIKK----------------------------------------------------- -----------------------------------------TSKPPARKKEEDCETEVSN SAKTSKPSKQEEANSQIKESKKNARNKENCI----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KEEICSDSLKHP---QKEM KLKTESPV--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED N----------------------------------------------------------- ----------------------------------TD-N---------------------- -----DD----------------------------------------------------- ------------------------------------------------------------ -D----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------STDKLEEAAVL---- ---------P-SVGLPSNP----VEIEIETPEQVKKRERR-------------EKRKAEF EMYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRNRICSQPDLLAIGLSIIPTRFT---- --QVSAGQVGLVYLSNLVKW----------FVGTFTVNDELSTEKGE-----PLQSTLER RFAIYTAKDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSFQPIPLKET R--------------------------------------PK------------------- ------------------------------------------------GK-SS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRLSHSSTSEGQKSSATTPKAVAKSC PCKKAKQDEKSSESKENNKEPKKPKTAQTERTQKSKLTKGSQAQKESNNE-TSSAEKDVP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SA------------------SD------- --------------------------------------------------------FE-- ----LSEEE---SDVSDEDFE-------------------------TVPKRRRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QASQNSKLTTVKRSKTNTSETRQ SENLYGAETKPAKSTTPALSEAQRK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DEGQ---------------------------------------- ------------------------------------------------------------ ---------Q------EVRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------M---------- ------------------------------------------------------------ ----------------GTDQWLEVFLEPEDKWVCVDCVH-GNVGQPQLCFAHATKPLFYV VGFDNDGSVRDVTQRYDPVWMTSTRKSRVDPEWWEETLQPYESPHVERDKKEQNEF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYQAIYPETAAILGYCRGEAVYS--RDCIHTLHS RDTWLKQARVVRIGEVPYKMVKGFSNRARKARLAEPANRDREDLALFGHWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFLPSMLPVGCVQLKLPNLN RVARKLDIDCAQAIT-----GFDFHGGYSHPVTDGYVVCEEYKEVLVAAWENEQAEMEKK EKEKREKRALGNWKLLTKGLLIRERLKQRY----------SIKSEPSAPE---------- ---------------------------TE------KGGGFSSD-EE------GAP----- ------------SSES--TVGNTAMYWPQNRQ--------------------L--E-KQ- ------E-EI-KTK---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGEAAQLFPFEK-L >ENSZALP00000021462 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------M KLETESPV--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE N----------------------------------------------------------- ----------------------------------TD-N---------------------- ----DDD----------------------------------------------------- ------------------------------------------------------------ -D----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------ATDKLEEAAAL---- ---------P-SVGLPSNP----VEIEIETPEQVKKRERR-------------EKRKAEF EMYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRNRICNQPDLLAIALSIVPVRFT---- --QVPAGQVGLVYLSNLVKW----------FVGTFTVNDELSTEKGE-----PLQSTLER RFAIYAAQDEEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSFQPIPLKET R--------------------------------------PK------------------- ------------------------------------------------GK-SS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRLSHSSTSEGQESFATTPKAVAKAC PCKKAKQDKKSSESKENSKEPKKPKTAQTKRTQ--KLTKGSQEQEESKNE-SSPAEKDVP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SA------------------SD------- --------------------------------------------------------FE-- ----LSEEE---SDVSDEDFE-------------------------SVPKRRRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QASQNSKLTTVKRSKPETSETRQ SENLCGAETKSAKSTTSALPQAKKK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DEGQ---------------------------------------- ------------------------------------------------------------ ---------Q------EVRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------M---------- ------------------------------------------------------------ ----------------GTDQWLEVFLEPEDKWVCVDCVH-GNVGQPQLCFAHATKPLFYV VGFDNDGSVRDVTQRYDPVWMTSTRKSRVDPEWWEETLQPYESPYVERDKKEENEF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKFQAIYPETAAILGYCRGEAVYS--RDCIHTLHS RDTWLKQARVVRIGEVPYKMVKGFSNRARKARLAEPANRDREDLALFGRWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFLPSMLPVGCVQLKLPNLN RVARKLNIDCAQAVT-----GFDFHGGYSHPVTDGYVVCEEYKEVLVAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRY----------SIKTEPSAPE---------- ---------------------------TE------KGGGFSSD-EE------GAP----- ------------SSES--TVGNTAMYWPQNRQ--------------------L--E-KQ- ------E-KI-KTK---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGEAAQLFPFEK-L >ENSJHYP00000003569 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RKRRA------------------------------------------- -----------------S------------------------------------------ -----------------------------PRPAAAKKRRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GRLIKKEEEEQE--------------------- ----------------EEEDDF-------------------------------------- -------------EEK--KP---------------------------------------- ---RIKK----------------------------------------------------- -----------------------------------------TSKAPARRKGEDCDTEVSN SAKTSKPSKREEAKSQVKESKKNARNKENCI----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KEETCSDSLKHP---QKEM KLETESPV--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EE N----------------------------------------------------------- ----------------------------------TD-ND--------------------- ----DDD----------------------------------------------------- ------------------------------------------------------------ -D----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------ATDKLEEAAAL---- ---------P-SVGLPSNP----VEIEIETPEQVKKRERR-------------EKRKAEF EMYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRNRICSQPDLLAIALSIVPVRFT---- --QVPAGQVGLVYLSNLVKW----------FVGTFTVNDELSTEKGE-----PLQSTLER RFAIYAAQDEEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSFQPIPLKET R--------------------------------------PK------------------- ------------------------------------------------GK-SS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRLSHSSTSEGQESFATTPKAVAKAC PCKKAKQDEKSSENKENSKEPKKPKTAQTKRTQ--KLIKGSQEQKESKNE-SSSAEKDVP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SA------------------SD------- --------------------------------------------------------FE-- ----LSEEE---SDVSDEDFE-------------------------SVPKRRRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QASQNSKLTTVKRSKTETSETRQ SENLCGAETKSAKSTTPALPQAKKK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DEGQ---------------------------------------- ------------------------------------------------------------ ---------Q------EVRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------M---------- ------------------------------------------------------------ ----------------GRDQWLEVFLEPEDKWVCVDCVH-GNVGQPQLCFAHATKPLFYV VGFDNDGSVRDVTQRYDPVWMTSTRKSRVDPEWWEETLQPYESPHVERDKKEENEF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKFQAIYPETAAILGYCRGEAVYS--RDCIHTLHS RDTWLKQARVVRIGEVPYKMVKGFSNRARKARLAEPANRDREDLALFGRWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFLPSMLPVGCVQLKLPNLN RVARKLNIDCAQAVT-----GFDFHGGYSHPVTDGYVVCEEYKEVLVAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRY----------SIKTEPSAPE---------- ---------------------------TE------KGGGFSSD-EE------GAP----- ------------SSES--TVGNTAMYWPQNRQ--------------------L--E-KQ- ------E-EI-KTK---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGEAAQLFPFEK-L >ENSCCEP00000003173 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------M---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED NA---------------------------------------------------------- ----------------------------------VD-D---------------------- -----DD----------------------------------------------------- ------------------------------------------------------------ -D----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------ATGKLEEAAVL---- ---------P-SVGLPSNP----VEIEIETPEQVKKRERR-------------EKRKAEF EMYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRNRICSQPDLLAVGLSIVPTRFT---- --QVPAGQVGLVYLSNLVKW----------FVGTFTVNDELSTEKGE-----PLQSTLER RFAIYAAQDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSFQPIPLKET R--------------------------------------PK------------------- ------------------------------------------------GKSSS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRLSNSSTSEVQESTATTPKAAAKKC PCKKAKQEEKSSESKENSVEPKKPKTAQTEVTHKSKLTKGSQEQKESNNE-TSSAEKDVP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SA------------------SD------- --------------------------------------------------------FE-- ----VSEEE---SDLSDEDFE-------------------------TVPKKRRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QASQNSKLTAIKRSKTETSETML SKNSYEAETKPAKSATSALPQAQKK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DDGQ---------------------------------------- ------------------------------------------------------------ ---------Q------EVRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------M---------- ------------------------------------------------------------ ----------------GTDQWLEVFLESEDKWVCVDCVH-GNVGQPQLCFAHATKPLFYV VGFDNDGSVRDVTQRYDPVWMTSTRKSRVDPEWWEETLQPYESPYVERDKKEENEF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKFQAIYPETAAILGYCRGEAVYS--RDCIHTLHS RDTWLKQARVVRVGEVPYKMVKGFSNRARKARLAEPANRDREDLALFGRWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFLPSMLPVGCVQLKLPNLN RVARKLDIDCAQAIT-----GFDFHGGYSHPVTDGYVVCEEYKEILVAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRY----------SVKTEPSAPE---------- ---------------------------TE------KGGGFSSD-EE------GAP----- ------------SSEG--AVENTAIYWPQNRQ--------------------L--E-KQ- ------E-EK-ITR---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGEASQLFPFEK-L >ENSFALP00000013189 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------VRPLPSLPSLPFPS-----------------------------------AG PGRACPLRSAMARKRRA------------------------------------------- -----------------S------------------------------------------ -----------------------------PRPAAAKKRRS-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GRL-RKEEEGEE--------------------- -------------------DDF-------------------------------------- -------------EEK--KP---------------------------------------- ---SIKK----------------------------------------------------- -----------------------------------------SSKAPAKKKEEDCDTEVSN SAKTSKPSKPEEAKSQIKESKKNARNKENCI----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KEETCSDSLKCP---QEEV KLKTESSI--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED N----------------------------------------------------------- ----------------------------------TD-N---------------------- -----ND----------------------------------------------------- ------------------------------------------------------------ -D----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------ATDKLEEVAVL---- ---------P-SVGLPSNP----VEIEIETPEQMKKRERR-------------EKRKAEF EMYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRNRICSQPDLLAIGLSIIPTRFT---- --QVPTGQMGLVYLSNLVKW----------FVGTFTVNDELSTEKGE-----PLQSTLER RFAIYAAQDDEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSFQPVPLKET R--------------------------------------PK------------------- ------------------------------------------------GK-SS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SKRLSHSSTSEGQESSATTPKAVAKKC PCKTAKQDEKSSEGKENNKE---PKTAQAEKTHKSKSTKGSQEQKETNNE-TSSAEEDVP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -G-----------------------------SA------------------SE------- --------------------------------------------------------FE-- ----VSEEE---SDVSDEDFE-------------------------TVPKRRRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QASQNSKLTTIKRSKTQTSETKL STNSCGAETKPAKDTTPALFQAQRK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DDGH---------------------------------------- ------------------------------------------------------------ ---------Q------EVRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------M---------- ------------------------------------------------------------ ----------------GTDQWLEVFLEPEDKWVCVDCVH-GNVGQPQLCFAHATKPLFYV VGFDNDGNVRDVTQRYDPVWMTSTRKSRVDPEWWEETLQPYQSPYVERDRKEENEF-QLK LHDQPLPTAIGEYKNHPLYALKRHLLKFQAIYPESAAILGYCRGEAVYS--RDCIHTLHS RDTWLKQARVVRVGEVPYKMVKGFSNRARKARLAEPANRDREDLALFGRWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFLPSMLPIGCVQLKLPNLN RVARKLNIDCAQAIT-----GFDFHGGYSHPVTDGYVVCEEYKDVLVAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRY----------SIKNEPPAPE---------- ---------------------------TE------KGEGFSSD-EE------GAP----- ------------SSES--AVGNTAMYWPQNRQ--------------------L--E-KQ- ------G-EK-TAK---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGEAAQLFPFEK-L >ENSNPEP00000006936 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DDF-------------------------------------- -------------EEK--KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RGNKAKVSAGKKGEDSGTGVCSS ASKPSKQKEVKLPVKEESKKTTKSKGKHKLQEP------------VTDKLED-AVV---- ---------P-AVVLPSKP----VEIEIETPEQAKNRERR-------------EKRKAEF EVYLRRMMKRFNKEIREDTHKVHLLCLLANGFYRNRICNQPDLLAIGLSVIPTHFT---- --KVPAGQVDLPRLSNLVKW----------FVGTFTVNDELSVEKGE-----PLQATLER RFAIYAARDNEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSLQPIPLKET R--------------------------------------AK-VSF--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------STSEGQESSATTPKAAAKKG FCGKAKRNEKSSGSEDDNREPKKPSSARTKRPCRSKLTRESQEQRETNNEDCSLGEKDRP A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESGS--- ----------------------------------------------------------DE -D-----------------------------SV------------------SD------- --------------------------------------------------------FE-- ----VSEEE---SSLSDEDFE-------------------------TLPKKQRRS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LGSQKSKVKADKNSKTKISELRL PKNSQEAEPRPAKNTATALPNAQRK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- -----------------DGE---------------------------------------- ------------------------------------------------------------ ---------Q------ELRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------GTDHWLEVFLEREDKWVCVDCVH-GSVGQPQLCFKNATKPLSYI VGFDNDGSIKDVTQRYDPVWMTVTRKSRVGSEWWKDTLRPYESPFVERDKKEEMEF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYEALYPESAAILGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRIGEVPYKMVRGFSNQARKARLMEPANREKQDLALFGRWQTEEFQPPVA VDGK--------------------------VPRNEYGNVYLFLPSMLPVGCVQLRLPNLN RVARKLDIDCAQAIT-----GFDFHGGYSHPVTDGYVVCEEYKEVLIAAWENEQAEIEKK EKEKREKRALGNWKLLTKGLLIRERLKQRYCSK-----LP-------APE---------- ---------------------------AE------KRAGFSSD-EE------GGP----- ------------SSET--AAGDLAASWPQNRQ--------------------A--E-KQ- ------KKEK-TTR---KSRRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKGEAAQLFPFEK-L >ENSMUNP00000007462 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------I----------------------------------------TYNSNSL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------KPP---PEEI KLKKESPI--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED N----------------------------------------------------------- ----------------------------------T------------------------- ------D----------------------------------------------------- ------------------------------------------------------------ -D----DD-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------QEP------------ATDNLE-AAAL---- ---------P---VLPSNP----IEIEIETPELLKKRERR-------------EKRKAEF EIYLRRMMKRFSKEVREDTHKVHLLCLLANGFYRNRICSQPELHAIGLSIIPTRFT---- --KVPAGQVDLHYLSNLVIW----------FVGTFTINDELSTDKGE-----SLQSTLER RFAIYAARDEEELVH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSLQPVPLKEA K--------------------------------------AK------------------- ------------------------------------------------VK-SS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------FMKQPFSSTSQGQKSSAITPKAAAKKC PCKKAKQEEKSSEGEEDKKEPEKPKTAQPKRPRKSQLTAGSQKQREPGNGESSLVEKDVP V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NN----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RRVASKVCYKEESDS--- ----------------------------------------------------------DE -G-----------------------------SV------------------SD------- --------------------------------------------------------FE-- ----VSEEE---SDLSDEDFE-------------------------AVSKRRRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MGSQKSKVTAIKSPEVETSQWRI SQNSSGAEPRPANSPSPALASAPKK----------------------------------- --------------------R----NK--------------------------------- -----------------------------------IISSDE------------------- ----------------DDG----------------------------------------- ------------------------------------------------------------ ---------Q------EVRK---------------------------------------- ---------------------------------A-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------GTDQWLEVFLEPEDKWVCVDCVH-GNVGQPQVCFTHATKPLSYV LGFDNDGSVRDVTQRYDPMWMTATRKSRVDPAWWEDTLQPYRSPYVQRDEKEENEF-LVK LQDQPLPTAIGEYKNHPLYALKRHLLKYQAIYPESAAILGYCRGEAVYS--RDCVHTLHS KDTWLKQARVVRIGEVPYKMVKGFSNQARKARLAEPTNQDKEDLALFGRWQTEEFQPPVA VDGK--------------------------VPRNEYGNVYLFLPSMLPIGCVQLKLPNLN RVARKLDIDCAQAIT-----GFDFHGGYSHPVIDGYVVCEEFKEVLIAAWENEQAEIERK EQEKREKRALANWKLLIKGLLIRERLKKRY----------SFKTEPSAPA---------- ---------------------------TG------KGAGSSSE-EG------GGP----- ------------SSEL--AAGNVDLFWPQNRQ--------------------L--E-MK- ------KEGK-TTR---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------IKGEEAHLFPFEK-L >ENSACAP00000013318 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SDSNKRKGRPSLQGAGKRPRRDGKPGDDFEAEKPKNAKRLPKASSEKKKKREHEE SVSTSSSYKNAEQKAKKPRIKEENRTVEKQGSYKKGERSSGLQSSPQKKGIKKEFTIKKK EE----EE-------------ESED-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------HEPEIELLEKIAAPT--------------- --------------LPKET----VEIEIETPEQAKKRERR-------------EKRQTEF ETYLRRMMKRFNKEVREDTHKVHLLCLLANGFYRNKICCQSDLQAIGLSIIPTRFT---- --KVPEDRVDRVYLSNLVKW----------FVATFTVNSDLS-DNEE-----GWQATLER RFAIYAARDEEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLCRLVLSVQPIPLKES ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LEKRNSSSKKCASAAVSTKSRG------ ----------------------SA------------------------------------ ------------------KKPK-------------------------------------- ---------------------------------------IAAPKCTGSHKTK-------- --------------------------------------QEAEQEKVSPRSQKEDKKPNTS ETKGTVNKSPVLSGTQKGNESAHH------------------------------------ ---------ESNLREKEGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------GK-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R Q-----------------------------------------RKVASKVSYKEESGS--- ----------------------------------------------------------DE -D-----------------------------SD------------------SE------- --------------------------------------------------------FS-- ----VSEEEEEDSSVSDEDFE-------------------------TPRRKQKSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LGVCKAKGTFEHRKRSGPLV SKGSRNSKTVDAPTQKTASPCSSNSVKKRNKIISSDEKGESDGGEQVTYKL--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------R---------- ------------------------------------------------------------ ----------------GTDQWAEVFLEREDRWVCVDCVH-GTVGQPSLCFKYATKPVCYI IGIDNTGYVKDITQRYDPAWMTTTRKTRVDPQWWEDTLEPYRTPLVEREKKEDREF-IVK HQDQPLPTSIGEYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCIHTLHS KDTWLKQARVVRIGELPYKMVKGYSNHARKARMAEPANRDKKDLPLFGLWQTEEYQPPIA VDGR--------------------------VPRNEFGNVYLFQPKMLPIGCVQLKLPNLN RVARKLDIDCVQAVT-----GFDFHGGYSHPVTEGYVICEEYKEVLVAAWENEEAEREKK EKEKREKRVLGNWKLLVKGLLIRERLKARY----------SIKNEAAGVV---------- ---------------------------VE------RGAGFSSD-DD--EEEKGGP----- ------------SSET--PAEDMAISWPQNRQ--------------------V--E-EQN ------KGSK-TTR---KSRRQ-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEAKHLFPFEK-L >ENSSMRP00000002986 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------M-------------------------------------------------- ------------R----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----NPIFASLGSRYSDLHNPTLKKDKSTKKGSTS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------V--------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ED K----------------------------------------------------------- ------------------------------------------------------------ -----ED----------------------------------------------------- ------------------------------------------------------------ -E----ED-------------ESEE-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------HEPEIEMLKDIAPPL--------------- --------------LPSKNIEKMVEIEIETPEQAKKRERR-------------EKRQSEF ETYLRRMVKRFNKEVREDTHKVHLLCLLANGFHRNRICMQPDLQAIGLSIIPVRFT---- --KAPAERIDRLYLENLVRW----------FVATFTINNELS-DAEE-----GWQATLQR RFAVYAAQNDEELVH--------------------------------------------- ---------------------------------IFLLILRALQLLCRLVLSLQPIPLKES A--------------------------------------MK------------------- ------------------------------------------------VKLSSKK----- ----------------------RSRTVSEELN---------------------G------ ----------------------SA------------------------------------ ------------------KKPK-------------------------------------- ---------------------------------------VTSGKCRGSPKTKNGAGQKEI LSSNQVAGDKSNCCGTQRTTNKATASDDAQKKKEFGSG---------------------- ------------------------------------------------------------ --------------EKEGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------GK-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------ND----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R Q-----------------------------------------RRIASKISYKEESGS--- ----------------------------------------------------------GE -D-----------------------------SS------------------SE------- --------------------------------------------------------FC-- ----ASEEEEEESNTSDEDFE-------------------------TPKRKPRSS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------LG------------------ --------------------------------------------------LAKSKPTVSR RQNCVPSTRKILKNSEEIEGSKEKMAPSTXTPL--------------------------- -----------------------KK----------------------------------- --------------------R----GK--------------------------------- -----------------------------------IISSDE------------------- ----------------DE-E---------------------------------------- ------------------------------------------------------------ ---------Q------QPVN---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------K---------- ------------------------------------------------------------ ----------------GIDQWVEVFLQREDRWVCVDCVN-GTVGQALQCYKRATKPVTYI IGIDNNAYVKDVTKRYDPAWMTSTRKHRVDAQWWEDTLEPYKSPFREREEKEEREF-SVK LQDQPLPTAIGEYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCIHTLHS KDTWLKQARVVRIGEVPYKMVKGYSNQARKARMAEPANRDKKDLALFGFWQTEEYQPPVA VDGI--------------------------VPRNEFGNVYLFQPSMLPIGCVQLKLPNLH RVARKLDIDCVPAVT-----GFDFHGGYSHPVTEGYVICEEYKEVLVAAWENEEAEREKK EKEKREKRVLGNWKLLVKGLLIKERLKERY----------SAKNEAVGMM---------- ---------------------------MG------KGAEFSSD-EE-------GP----- ------------SSQT--PAGDMAVSWPQNRQ--------------------A--E-EWN ------KEGK-RTK---QTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEAKHLFPFEQ-L >ENSCPRP00005025558 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------EM---------------------------------- ---------------------------------------------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EN S----------------------------------------------------------- -------------------------------------D---------------------- -----DS----------------------------------------------------- ------------------------------------------------------------ -N----ED-------------ESED-EWEDVE---------------------------- ------------------------------------------------------GKNLLM WPYQLSDILWDSLTDSDCFQWNLSIFMQGPVNGHSAWHVTDGTLPGMHVGLSIKSETNFL GQESRKGGAQKITEIFYLVPSY-------------------------------------- ------------------------------------------------------------ ---------------------------------------R-------------EKRKTEF ETYLRRMMKRFNKEVHEDTHKVHLLCLIANGFYRTRICNQPDLQAIGLSIIPNHFT---- --KVPAGRVDVLYLSNLVKW----------FVGTFTINTELSVEDGE-----NMQCILER RFAIYAARDNEELIH--------------------------------------------- ---------------------------------IFLIILRALQLLCRLVLSLQPIPLKEV A--------------------------------------GK------------------- ------------------------------------------------GK-SS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------R-------------------------------------------PSVSG VTKEQEGSVRNPKKSSGPRAKKKEALLDNARADKKPKKSDIPGT---------------- -----------------KRVSKSKMAKHVQEQKESSAEEGSPGEKE-------------V L----------------------------------------------------------- --------------------------------------RTK------------------- ------------------------------------------------------------ -----------------------------------------------------NN----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RSVASKVSYKEESGS--- ----------------------------------------------------------GG -D-----------------------------SD------------------SE------- --------------------------------------------------------FE-- ----ASEEE---SSVSDEDFE-------------------------IVPRKQRRSSGPKK ----PGVTVKSNRKAWPLESKLPKNSGEAEHALAKKAALGSFNSP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------K----SK--------------------------------- -----------------------------------IISTDE------------------- ----------------DDME---------------------------------------- ------------------------------------------------------------ ---------Q------EMVK---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------SADQWLEVFVEREDKWVCVDCVR-GTVNQPQLCFRYATKPVSYI VGIDNDGCVKDITQRYDPAWMTLTRKYRVDPEWWEETLEPYKSTFVERDKKEEMEF-QVK LQDQPLPTAIGEYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYS--RDCVHTLHS RDTWLKQARVVRIGEVPYKMVKGYSNHARRARLAEPANRDKDDLALFGLWQTEEYQPPVA VDGK--------------------------VPRNEYGNVYLFLPCMLPVGCVQLKLPNLN RVARKLGIDCVQAVT-----GFDFHGGYSHPVTDGYIVCEEYREVLVAAWENEQAEMERK EKEKREKRALGNWKLMVKGLLIRERLKQRYCNKVFETSG--------------------- ---------------------------ME------KGAGFSSD-EE------EGP----- ------------SSET--PAEDVAAFWPLNRQ--------------------V--E-KQ- ------DEEK-KVR---KSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEAAHLFPFEK-L >ENSECRP00000026714 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------PKRRG------------------------------------------- -----------------SVDA--------------------------------------C --------------AKAET----------------KRAKG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------PAVKKTGSQRKMTDANDNKVTVGAKQGRKNSKVARE LTS---------------KP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------KK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EDSEINSQILDQMQIISFSTVDHG----------------------- ---------------------------------------------DNSS----------- ------GEE-------------------------------PCLKA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----EE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------ESED-EWQEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP------------VSFESG-VSAL---- ---------S-EPVLPSKP----VEIEIETPEQARKRQKR-------------EKRKAEF ETYLRRMMNRFSKDLQVETHKVHLLCLLANGFFRNRVCNEPDLHAIALSIIPTRFT---- --QDVPEKMDLFFLSNLAKW----------FTSAFVLNPHLSLDENE-----NLQVRLEK RFAQFAARDTNEMTH--------------------------------------------- ---------------------------------IFLIILRALRLFCRLVISLQPISIKSL P--------------------------------------GK------------------- -----------------------------------------KNLSSA-NKEKPEKKELEE SKVNIKKEDDDMVPLKIQGVNKRAAT---------------------------G------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TRSK------------------------- ------------------------------------------------------------ ----------------------------------------KMAKK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------QR-------------------------------------------P---- ------------------------------------------------------------ ---------------------------------------------SDCKDDKSQNSKEAL Q----------------------------------------------------------- --------------------------------------KTK------------------- ------------------------------------------------------------ -----------------------------------------------------NN----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R L-----------------------------------------RKVASKVSYKEDSDE--- ----------------------------------------------------------QD -G-----------------------------SD------------------SD------- --------------------------------------------------------FQ-- ----LSHGS--------------------------------------------------- -----------------------------------------------------------D SS---------------------------------------------------------- ---------------------YSEGEKEKEKKTVGGSRGTSIPAKRKSFGKSNKEKKE-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------Q----SK--------------------------------- -----------------------------------VLSEDD------------------- ------------------EE---------------------------------------- ------------------------------------------------------------ ---------L------DKKG---------------------------------------- ---------------------------------M-------------------------- -------------------------------------------------Q---------- ------------------------------------------------------------ ----------------GTDQWVEVYLERFGKWSCIDCMA-PSVNQPQNCFKHATKPVKYI VGFDNNNFVKDVTRRYDPAWMTSTRKLRVSPEWWEETLLYYQSPITEREKKEDQQL-QTQ LLDQPLPASVSEYKNHPLYALERHILKYEAIYPPTATVLGYCRGEAVYS--RDCVHTLHS RDTWLKEAKVVKLGEVPYKMVKGFSNRARKARMMEAESREKNDLGLFGLWQTEEYQPPVA VDGK--------------------------VPRNDYGNVYLFRPCMLPIGCVHLQVPNLH KVARKLEIDCAPAVT-----GFDFHCGFSHPVVDGYVVCEEFKEVLLAAWENEQVEIERK QQEKREKRVLANWTLLTKGLLIKERLKKRY----------QLQSKPEENM---------- ---------------------------GD-----AAGDGFSSD-EE-------VP----- ------------NSQT--TATDVASSWPQNRQ--------------------GP-EGKE- -----------TLR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEEKHLFPFEK-L >ENSDARP00000058099 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRK--------------------------------------------- -------------------------------DTR-------------------------- --------------QKSDT----------------KKPKQI--------ANTKS------ -----------------------GSKTQKA------KENGM------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------ETKKNLKNSKVA SRRSRKVKDVLDEV------------------------TSKYFQD--------------- ------------------------------------------------------------ -SEVK------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TEEPEDLSDHSE------------------------ ------------------------------------------------------------ -------------------------------------------ERMIIEDTSLSKQ---- ---------------------------------------------------------VK- ----EEE----------------------------------------------------- ------------------------------------------------------------ -E----DS-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EM------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AGP--------------------------- L---GPVDSS-ELALESKP----VEIEIETPDMIRKRQKK-------------EKRKAEF ETYLRRMMNRFNKDLLVDTHKVHLLCLMASGLFRNRLLCEPDLLAVALSLLPSHFT---- --TVSLKRINNGFLEGLLKW----------FQATFTLNPALPEEKEV-----DLRTVLEK RMGCLSARNHEEMTY--------------------------------------------- ---------------------------------LFLLVLRSLRLFCRLVLSLQPLPLKP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PPA----------------------TKSKTTPSKSSSEKA QSEK-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---SSPELKVS--------PG----------------SK--------------------R PSSATAAAKEDR------------------------------------------------ ------------------------------GGKRKKKTG--------------GGG---D KE----AAGAQK-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R R-----------------------------------------RSVASKVSYKEVGSE--- ------------------------------------------------------------ ----------------------------------------------EEEEQSE------- ------EE------------------------------------------------FQ-- ----PSN---------EDDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ GAVKICRKSKVKSRRSSKVKQEERS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------EEE---------EEEEEE------------------------- EEEEK-----------EVKKQRR------------------------------------- ----------------KKKQ---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------K---------- ------------------------------------------------------------ ----------------GADEWLEVYLESSGRWVCVDVDQ-G-VGQPQLCSDQATLPITYV VGLDDEGFMKDLGSRYDPTWLTSSRRRRVDSEWWEETMELYKSPDTERGQKEDQEM-QAK LLDKPLPTSVSEYKNHPLYVLKRHLLKYEALYPATAAVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVLGFSNRSRKARMMS-EQKNVKDLALFGTWQTEEYQPPIA VDGK--------------------------VPRNEFGNVYMFKSCMLPIGCVHVHLPNLH RVARKLNIDCALAVT-----GFDYHCGFAHAVNDGYIVCEEHEEILKAAWENEQEIQQKK EQEKREKRAVTNWTLLVKGLLIKERLKRRY----------GQQ----------------- -----GLASGTGLKQGKEG---GAE-------------GLSSD-EE----------KE-- -G----------GAQSAQAPPSLTASWPQNRK--------------------E--E-AEE KIV----R----R----VSNRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGEEKHLFPFEK-V >ENSPNAP00000031862 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KH---------------------------------------------- ------------------------KNIADEKDT--------------------------- ------------------T----------------KKLKQV--------A---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----KKSKAPKTPKTKENTTGAKNVPKN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------SKPRGRASKKVTKPV------------------------------------ ------------------------KEEPEDMSDSSEDVGVTFPE---------------- ------------------------------------------------------------ C---------------------------------K---IP--NDKM-------------- ----------------------------------------------------------KE EEDGESE----------------------------------------------------- ------------------------------------------------------------ -E----SD-------------ED---EWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PGP--------------------------- L---GPVDTELEPAVPSQP----VEIEIETAEAMHKRQRK-------------EKRQAEF ETYLRRMMKRFNKELLEDTHKVHLLCLLAGGLFRNRLCCEPDLLAIALSLLPVHFT---- --SVVTERINTGFLEGLLKW----------FRVTFTLNPELPEEKGV-----ELREVLER RLGSLSARDHQEMTY--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPVPFKQP A--------------------------------------KK------------------- ------------------------------------------------DK---------- ------------------------------------------------------------ ------------------------------------------------------------ -TQSSTSPAAKNISDEPDEKP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----EKPKVS--------PGFKRSSANT-------ATK--------------------R ----------QR------------------------------------------------ ------------------------------GGKKQKKNE--------------SGKEDEE KE----AAVGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NT----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSIASKVSYKEESSE--- ------------------------------------------------------------ ----------------------------------------------EEEEASE------- -----GEE------------------------------------------------FQ-- ----LTS---------EEESD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DS------------------------------------- ------------------------------------------------------------ ----------------------------------------------------------KD GA--------------------KRSKRCSKTKRKDK------------------------ ------------------------------------------------------------ -----------------------------------------GK----------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------VQ--------------------------- --------------------RRSSGVKKGAK----------------------------- --------------------KEEE--DVDY------------------------------ ----------------EEEE---------QEET--------------------------- -------------------KSQG------------------------------------- ----------------RRRH---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------K---------- ------------------------------------------------------------ ----------------GDDEWIEVYLDGAKRWVCVDVNQ-G-VGKPQLCTNQATQPITYV VGVDSDGYLKDLSARYDPTWLTSSRRRRIDSEWWEETLDFYECPDSEREQQEDKEL-QDK LLDKPLPTSVSEYKNHPLYALERHLLKYEALYPRTAAILGYCRGEAVYS--RDCVHTLHS KDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMMS-EQKDYKDLALFGHWQTEEYQPPLA IDGR--------------------------VPRNEFGNVYMFKPCMLPVGCVHLRLPSLH RVARKLDLDCAAAVT-----GFDCHGGYSHAVTDGYIVCEEHQEILKAAWENEQEIQQKK EQEKREKRALSNWTLLVKGLLIKERLQRRY----------GQQ----------------- -----GLAKGTGLGQGDE-----VG------------AGLSSG-EE----------DE-- -G----------GAHT--APPMLAASWPQNRQ--------------------E--E-QDE GGA----K----KS---LSRRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------RRGQDKHLFPFEKSK >ENSEEEP00000044328 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---MCF-----------SSENGKGRKR--------------------------------- ------------------------------------------------------------ ----------------------VGRNAKSRCRTSKKADDP-------SE--RKTSKYFQI SGLLKEEADS-------------------------------------------------- ------------K----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------SDISEDVGETFPESTGVDDEMEED----- ----------------------------------------------------KEE-KKNN ------------------------------------------------------------ ------------------------------------------------------------ ----ESE----------------------------------------------------- ------------------------------------------------------------ -E----SD-------------DDDE-EWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AAP--------------------------- L---GPGSTELEPTFSSQP----VQIEIETAEAMHKRQRK-------------EKRQAEF ETYLRRMMKRFNKELVEDTHKVHLLCLLASGLFRNRLCCEPELLAITLSLVPVHFT---- --TVVAERINTGFLEGLLKW----------FQVTFTLNHTLPEDRGM-----ELREVLER RLGSLSVRDHQEMTY--------------------------------------------- ---------------------------------VFLLVLRSLRLLCRLVLSLQPLPLKPL T--------------------------------------KK------------------- ------------------------------------------------DK---------- ------------------------------------------------------------ ------------------------------------------------------------ -AQTSISPPAQDKSDKPDEKP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----PEPKVS--------PG----------------SK--------------------R PSSAVSEGKTER------------------------------------------------ ------------------------------GGKRQKKKE--------------QGGED-- -------MGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NN----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESSEGEG PSEGEEFRLSGEDESDESEGGVKKSSKNSKAKRKGKVRVPQRLSGNQKKTTREEKDKEEG EQ-E---------------------------------------TKKE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------RG------------------------------------- ----------------KRRE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------K---------- ------------------------------------------------------------ ----------------GDDEWIEVYLVGAKKWVCVDVNQ-G-VGKPLQCTNRASQPVTYV VGVDGDGYLKDLSSRYDPTWLTLSRRRRIDSEWWEETLEFYECPDSERKQQEDKEM-QDK LLDKPFPTAISEYKNHPLYVLERHLLKYEVIYPRSAATLGYCRGEPVYS--RDCVHTLHS KDTWLKEARTVRLGEEPYKMVKGFSNRSRKARQMS-EQKDENDLALYGRWQTEEYQPPLA IDGK--------------------------IPRNEFGNVYMFKPCMVPVGCVHLCLPNLH RVARKLDLDCAAAVT-----GFDFHGGYSHAVTDGYIVCEEHEDILKAAWENEQEIRQKK EQEKREKRAVANWTLLVKGLLIKERLQRRY----------GQR----------------- -----GLTKGVELGQQDEG---RVG-------------GLSSG-EE----------EE-- -G----------GAQD--APPTLAASWPQNRQ--------------------Q--E-LKA GET----M----TS---LSNKE-------------------------------------- ------------------------------------------------------------ -------------------------------------------ERGQQKHLFPFEKSV >ENSIPUP00000009576 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRKHR-------------------------AEAAATEKDNTKKKLSQA VKKRKAAPKTPSIKDKGT----KAKNVA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------KPRGQASKKAHKPTDEK--------------------------------- ---------------KSKYFSEPFKEEPED---------------------IFEDSSMSL PESSVLKSSD-------------------------------------YK--MKEE-KKES ------------------------------------------------------------ ------------------------------------------------------------ ----DIE----------------------------------------------------- ------------------------------------------------------------ -S----DE-------------SDDE-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AGP--------------------------- L---APTEADQEPAVPSQP----VEIEIETAEARHKRQKK-------------EKIQAEF EIYLRRMMKRFNKGIQEDTHKVHLLCLLASGLFRNRLCCEPDLLAITLSLVPTHFT---- --KVIKKRINTVYLEGLLKW----------FKVTFTLNPALPEEKDV-----GLRKLLER RLGSLSARDHQEMTY--------------------------------------------- ---------------------------------LFLLVLRSLHLYCRLVLSLQPIPLKPS T--------------------------------------NM------------------- ------------------------------------------------DK---------- ------------------------------------------------------------ ------------------------------------------------------------ -APTSSSSSSKVKSNEADKKP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----PEPKVS--------PG----------------SK--------------------R PSTLSIEGQPKR------------------------------------------------ ------------------------------GGKRQKRNV--------------ADRGDKE KE----AVGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NT----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSIASKVSYKEVSSD--- ------------------------------------------------------------ ----------------------------------------------EEDELSD------- -----GEE------------------------------------------------YK-- ----PTR---------EDESD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSDCDAK-------------------------------- ------------------------------------------------------------ ------------------------------RSNRYSNAKGKGKSQAPLRSSKPQKRTKK- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------EE---------EEETDE------------------------- EEEQI-----------KGKKQYG------------------------------------- ----------------RRRQ---------------------------------------- ---------------------------------V-------------------------- -------------------------------------------------K---------- ------------------------------------------------------------ ----------------GDDEWIEVYLKGAKRWICVDVDQ-G-VGQPERCSNKATQPITYV VGVDEDGYLKDVSSRYDPTWLTSSRRRRINSDWWEETLSFYACPDNKQKQEEDKEL-QDK LIGKPLPKVISEYKNHPLYALERHLLKYEALYPPTAAILGYCRGEAVYS--RDCIHTLHS RDIWLKKARTVRLGEEPYKMVKGCSNHSRKARRMS-ENKDKKDLGLFGHWQTEEYQPPAA INGK--------------------------IPRNEFGNVYMFQPCMLPVGCVHVHLPNLN RVARKLDLDCAPAVT-----GFDFHGGHSHAVTDGYIICKEHEEILKAAWENEQEIQRKK EKEKREKRALANWKLLVKGLLIKERLQRRY----------GQQ----------------- -----GVAKDTGIAE-----------------------GFSSG-EE----------DE-- -G----------GAHT--APPSLAVSWPQNRQ--------------------E--E-KEE GGA----K----KS---VSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------RRGQHKHLFPFEKRV >ENSTNIP00000014994 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------KKKV-------------EK--------------------------------- ------------------------------------------------------------ ---------------------------------------------------------DAE ------------------------------------------------------------ ------------------------------------------------------------ ----GEQ----------------------------------------------------- ------------------------------------------------------------ -D----SE-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP--------------------------- L---GPVEAQ-EPALPSQS----LEIEIETPEV----RKE-------------RKRQAEW ETYVRRMVNRYKKDLLVDMHKVHLMCLIARGMFQNRLCSQPDLLAITLSLLPTHFS---- --MVAKDRVDQNFLSGLLRW----------FRTTFTLNPSLPCERRA-----DPRLLLEG RLASLSARNHEEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPVPLKLP P--------------------------------------AKVLTLGSVVHLEVLPCQQQF DILGFILLNHSFSRLLIFVQQ---------------------------GK---------- ------------------------------------------------------------ ----------------------SAARTSEKSNANQEKRRCDPKQTGDKRPINGTPS---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------AGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T R-----------------------------------------RSIASKVSYKEESSS--- ----------------------------------------------------------DG E---------------------------------------------E--KAAS------- -----DDD------------------------------------------------FQ-- ----VSSE--------EED----------------------------------------- ------------------------------------------------------------ ---GVDSENEAISTKRAGKRRSKQDSGGKRKQDSRPG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------NGAKRRSG------------------------------------- ----------------RKKE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------L---------- ------------------------------------------------------------ ----------------GDDEWLEVYLAKTSSWICVDVEQ-G-IGMPHLCSQKASSPVTYV VSVDGDGFVKDLGRKYDPTWMTLSRKRRVEEDWWEDTLAPFMGPEDEKDQKEDKEL-QKT LLNKPLPISVAEYKNHPLYALKRHLLKYEAIYPSTAAVLGYCRGEAVYS--RDCVHTLHS RDTWLKEARTVGLGEEPYKMVKGFSNRSRKARMMS-ELKNENDLALFGEWQTEEYQPPIA VDGK--------------------------VPRNDFGNVYLFKPSMLPVGCVHLRLSNLH RVAKKLSIDAAPAVT-----GFDFHGGYSHAVTDGYIVCEEFEEILQAAWLEEQELLKQK EKEKREKRVTSNWALLVKGLLIREKLKKRY----------STKNQGLRT----------- ------------------------------LADGDEPGGLSSD-EE--AQEGASP----- ------------AAKT--ASETLAMSWPQNRQ--------------------E--E-EEK DFVSGLQK----KK---MTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGQDKHLFPFEK-A >ENSTRUP00000027086 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRSKC-------------------------A----VK----------- ------------------------------------------------------------ ---------------KTDT----------------KK----------------------L KRDLKGK------------------------------QSGVNLQVKKENTG--------- ------------------------------------------------------------ -------------------------------------------------IT--------- ----------------------------------EEEENL-------------------- --------------------------------ERKV------------------------ ------------------KQ----------------------------KPR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------HSKNQAT---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------SSLK---------------------------------------- ------------------------------------------------------------ ---------------------------------------EEER--D-----------SE- ----------------------------------------------EDFD---------- -------------------RG------------KSAAPPGW------------------- ------VNNKKV-------------EK--------------------------------- ------------------------------------------------------------ ---------------------------------------------------------EDE ------------------------------------------------------------ ------------------------------------------------------------ ----GEE----------------------------------------------------- ------------------------------------------------------------ -E----SE-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MEP--------------------------- L---GPVEPP-EPVLPSQT----LQIEIETPEV----RKE-------------RKRKAEW ETYVRRMVNRYKKDLLVDIHKVHLMCLIASGMFRNRVCSEPDLLAITLSLLPTHFS---- --MVAKERIDQNYLSGLLKW----------FRATFTLNPSLTCDQQT-----DPQALLER RLASLSARNHEEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLLCRLIFSLQPIPLKLP P--------------------------------------SK------------------- ------------------------------------------------GK---------- ------------------------------------------------------------ ----------------------DAAGPSEKSNANQEKK--------------GTDSKQ-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------S--------PG----------------NK--------------------R PI------------------------KEGKSKADR------------------------- ------------------------------GRKKAK------RTGEER------EAEDKE EE-KSTTLAGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSIASKVSYKEESSS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GADEKLVSEDDFQAPSEEECIV-- ---------------------DSESEEKSTK----------------------------- ---------------------------------------RAAGKRKS------------- ------------------------------------------------------------ -------------------------------------------------------KSD-- ------------------------------------------------------------ -----------W------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------TKTNTAQKQQKSGGNLKQDSRELEEKKEMEEGGG EGGTRTM----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------RSGAKRRSG------------------------------------- ----------------QKKG---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GDDEWLEVYLAKTSSWICVDVDH-G-IGKPHLCSQNATSPVTYV VSVDGDGFVKDLGRKYDPTWMTLSRKRRVDEEWWEETLTPFMGPEDEKDKKEEKEL-QNT LLNKPLPLSVAEYKNHPLYALKRHLLKYEAVYPSTAAVLGYCRGEAVYS--RDCVQTLHS KDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMMS-ETKNENDLALFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCAHLRLSNLH RVAKKLSIDAAPAVT-----GFDFHGGYSHAVTDGYVVCEEFEEILRAAWVEEQELQKQK EKEKREKRVISNWTLLVKGLLIREKLKRRY----------SKKNQGLRI----------- ------------------------------LADGEEPGGLSSD-EE--AGEGASP----- ------------AAKN--ASETLAMSWPQNRQ--------------------E--E-EDK DCVSGLQK----KK---MTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQGKHLFPFEK-P >ENSXMAP00000019407 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRRKC-------------------------AET--------------- ------------------------------------------------------------ ---------------EADT----------------KKPKQVLNAEGRG-AKTRS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------RKKAPENDPA--------- ----------------------------------EKEERL-------------------- --------------------------------ERKV------------------------ ------------------NP----------------------------KPR--------- --------LS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S------ ------------------------------------------------KRAAQNKSSSTT II---------------------------------------------------------- ------------------------------------------------------------ ----------------SA-----------------DSKTSKYFQ--S------------- -----------------------------------------------LP----------- ---------------------------------------KEEV--N-----------SE- ----------------------------------------------DDFEMPTAAPA--- -------------------------------------------------AV--------K K------STKKP-------------EE--------------------------------- ------------------------------------------------------------ -----------------------------------------------------EE-EKEE ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -D----DS-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPAETP-EPVLSPQP----VEIEIETAEV----RKQ-------------KKRQAEF ETYLRRMMKRYKKDLLIDTHKVHLLCLLANGMFRNRLCSEPDLLAVALSLLPPHFC---- --TVAREHIDQNYLSGLLKW----------FRATFTLDPSLPTEERP-----DPQALLQR RLGSLSARDHQEMTH--------------------------------------------- ---------------------------------LFLLFLRSLQLFCRLVLSLHPVLFKPP S--------------------------------------SK------------------- ------------------------------------------------SK---------- -----------------------------------------------------GAKTSTG AAER-------------------------------------------------------- ------------------------------------------------------------ -----------------CQTS--------------------------------------- ------------------------------------------------------------ ---------------------------QES------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --SNSPETKVS--------PG----------------TK--------------------R RA------------------------QGEKVKGSS------------------------- ------------------------------RGKKAKRKEMK----------------EEE EE-KPVLSGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVNYKEESNS--- ----------------------------------------------------------EA DE-E------------------------------------------EKEEASD------- -----AEE------------------------------------------------YQ-- ----ESS---------EDD---FETSTKPARKRTGLGK---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SSEKTSSTQGALKRRRTG GKQQEKNEDGEW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EEGK-------------------------------------------------- ------------------------------------------------------------ -EEE--DDEDEGTTSNRAKGRSR------------------------------------- ----------------QRKD---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWIEVYLDKSSSWVCVDVEH-G-VGVPHLCSQNATAPLTYV VAVDGDGFLKDLGRKYDPTWMTASRKRRVDDEWWEDTLEPFMGPEDERDKREEKEL-QSK LLNKPMPTSIAEYKSHPLYALKRHLLKYEALYPPTAAVLGYCRGEPVYS--RDCVRTLHS RETWLKEARTVRLGEEPYKMVKGFSNRSRKARMMS-EMKDENDLPLFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKACMIPVGCVHLRLPNLH RVARKLDLDAAPAVT-----GFDYHGGYSHAVTDGYIVCEENEEVLRAAWVEEQEIQKQK EKEKKEKRAIASWTLLVKGLLIRERLKQRY----------SQKSPGLGS----------- ------------------------------LTPGEEAGGFSSD-ED--GVEVDLP----- ------------GAKT--ASETLALSWPQNRQ--------------------A--E-EDA DPGKQ-KK----KK---TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEKHLFPFEK-V >ENSGAFP00000003965 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRRKC-------------------------AET--------------- ------------------------------------------------------------ ---------------EADT----------------KKPKQVLNAEGRG-AKTRS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------RKKAPENDPA--------- ----------------------------------EKEERL-------------------- --------------------------------ERKV------------------------ ------------------NP----------------------------KPR--------- --------LS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------L------ ------------------------------------------------KRAAQNKSSPAT NS---------------------------------------------------------- ------------------------------------------------------------ ----------------TA-----------------DSKTSKYFQ--S------------- -----------------------------------------------LP----------- ---------------------------------------KEEV--N-----------SE- ----------------------------------------------DDFEMLTAAPA--- -------------------------------------------------AV--------K K------STKKP-------------EE--------------------------------- ------------------------------------------------------------ -----------------------------------------------------EEKEEEE ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -D----DS-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPAETP-EPILPSQP----VEIEIETAEV----RKQ-------------KKRQAEF ETYLRRMMKRYKKDLLINTHKVHLLCLLANGMFRNGLCSEPDLLAVALSLLPPHFC---- --TVARERIDQNYLSGLLKW----------FTATFTLDPSLPIEERP-----NAQALLHR RLGSLSARDHQEMTH--------------------------------------------- ---------------------------------LFLLFLRSLQLFCRLVLSLHPVSFKPP S--------------------------------------SK------------------- ------------------------------------------------SK---------- -----------------------------------------------------GAKTSTG AAER-------------------------------------------------------- ------------------------------------------------------------ -----------------CQTG--------------------------------------- ------------------------------------------------------------ ---------------------------QER------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --SNSPETKVS--------PG----------------TK--------------------R QA------------------------QGEKVKGSS------------------------- ------------------------------GGKKAKRKEMK----------------EEG EE-KPVSSGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVNYKEESNS--- ----------------------------------------------------------EA DE-E------------------------------------------EEEEASD------- -----AEK------------------------------------------------YQ-- ----ESS---------EDD---FETSTKPARKRTGNGK---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------RSEKNSSTQSALKKRSPG GKQQEKNEDSEW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EE--DDEDEGMTSNRVKRRSR------------------------------------- ----------------QRKD---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWIEVYLVKSSSWVCVDVEH-G-VGVPHLCSQNATAPLTYV VAVDGDGFLKDLGRKYDPTWMTASRKRRVDDEWWEDTLEPFMGPEDERDKREEKEL-QSK LLNKPMPTSIAEYKNHPLYALKRHLLKYEALYPPTAAVLGYCRGEPVYF--RDCVHTLHS RETWLKEARTVRLGEEPYKMVKGFSNRSRKARMMS-EMKDENDLPLFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKACMIPVGCVHLRLPNLH RVARKLDLDAAPAVT-----GFDYHGGYSHAVTDGYIVCEEDEEVLRAAWVEEQEIQKQK EKEKKEKRAIASWTLLVKGLLIRERLKQRY----------SQKSQGLGS----------- ------------------------------LAPGEGAGGFSSD-ED--GVEVDLP----- ------------GAKT--ASETLALSWPQNRQ--------------------A--E-EDA DPGKQKKK----KK---TAKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEKHLFPFEK-V >ENSPMEP00000025452 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRRKC-------------------------AET--------------- ------------------------------------------------------------ ---------------EADT----------------KKPKQVLNAEDRG-AKTRS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------RKKAPENDPA--------- ----------------------------------EKEEKL-------------------- --------------------------------ERKV------------------------ ------------------NP----------------------------KPR--------- --------WS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S------ ------------------------------------------------KRAAQNKTSSAT NT---------------------------------------------------------- ------------------------------------------------------------ ----------------SA-----------------HSKTSKYFQ--S------------- -----------------------------------------------PP----------- ---------------------------------------KEEV--N-----------SD- ----------------------------------------------DDFEMPTAAPP--- -------------------------------------------------VV--------K K------STKKP-------------EE--------------------------------- ------------------------------------------------------------ -----------------------------------------------------EE-EKEE ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -D----DS-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPAETP-EPVLPSQP----VEIEIETAEV----RKQ-------------KKRQAEF ETYLRRMMKRFKKDLLIDTHKVHLLCLLANGMFRNRLCSEPDLLAVALSLLPPHFC---- --TVARERIDQNYLSGLLKW----------FRATFTLDPSLPTEERP-----DPQALLER RLGSLSARDHQEMTH--------------------------------------------- ---------------------------------LFLLFLRSLQLFCRLVLSLHPVPFKPP S--------------------------------------SK------------------- ------------------------------------------------SK---------- -----------------------------------------------------GARTSTG APER-------------------------------------------------------- ------------------------------------------------------------ -----------------CQTS--------------------------------------- ------------------------------------------------------------ ---------------------------QES------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --SNSPETKVS--------PG----------------TK--------------------R PA------------------------QGEKVKGSS------------------------- ------------------------------GGKKAKRKEMK----------------EEE EE-KPVLSAGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESNS--- ----------------------------------------------------------EA DE-E------------------------------------------EEEEASD------- -----AEE------------------------------------------------YQ-- ----ESS---------EDD---FETSSKRARKKMRNAT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SSEKTSRTQGTRKRRRTG ----GKNEDGEW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EECK-------------------------------------------------- ------------------------------------------------------------ --EE--DDDDEGTTSNRAKRRSG------------------------------------- ----------------QRKD---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLDKSSSWVCVDVEH-G-VEAPHLCSQNATAPLTYV VAVDGDGFLKDLGRKYDPTWMTASRKRRVDDEWWEDTLEPFMGPEDERDKKEEKEL-QSK MLNKPMPTSIAEYKNHPLYALKRHLLKYEALYPPTAAVLGYCRGEPVYS--RDCVHTLHS RETWLKEARTVRLGEEPYKMVKGFSNRSRKARMMS-EMKDENDLPLFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKACMIPVGCVHLRLPNLH RVAKKLDLDAAPAVT-----GFDYHGGYSHAVTDGYIVCEEDEEVLRAAWVEEQEIQKRK EKEKKEKRAIASWTLLVKGLLIRERLKQRY----------SQKSQGLGS----------- ------------------------------IAPGEEAGGFSSD-ED--GVEVDPP----- ------------AAKT--ASETLALSWPQNRQ--------------------A--E-EDA GPGKQKKK----KT---TTRRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEKHLFPFEK-V >ENSPLAP00000017491 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRRKC-------------------------AET--------------- ------------------------------------------------------------ ---------------EADT----------------KKPKQVLNAEDRG-AKTRG------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------RKKAPENDPA--------- ----------------------------------EKEEKL-------------------- --------------------------------ERKV------------------------ ------------------NP----------------------------KPR--------- --------WS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S------ ------------------------------------------------KRAAQNKSSSAT NTRS-------------------------------------------------------- ------------------------------------------------------------ -------------KTI-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K K------STKKP-------------EE--------------------------------- ------------------------------------------------------------ -----------------------------------------------------EE-EKEE ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -D----DS-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPAETP-EPVLPSQP----VEIEIETAEV----RKQ-------------KKRQAEF ETCLRRMMKRFKKDLLIDTHKVHLLCLLANGMFRNRLCSEPDLLAVALSLLPPHFC---- --TVARERIDQKYLSGLLKW----------FRATFTLDPSLPTEERP-----DPQALLER RLGSLSARDHQEMTH--------------------------------------------- ---------------------------------LFLLFLRSLQLFCRLVLSLHPVPFKPP S--------------------------------------SK------------------- ------------------------------------------------SK---------- -----------------------------------------------------GPRTSTG APER-------------------------------------------------------- ------------------------------------------------------------ -----------------CQTS--------------------------------------- ------------------------------------------------------------ ---------------------------QES------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --SNSPETKVS--------PG----------------TK--------------------R PA------------------------QGEKVKGSS------------------------- ------------------------------GGKKAKRKKMK----------------EEE EE-KPVLSAGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESNS--- ------------------------------------------------------------ -E-E------------------------------------------EEEEASD------- -----AEE------------------------------------------------YQ-- ----ESS---------EDD---FETCTKRARKKMRNAK---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SSEKTSRTQGTRKRRRTG ----EKNEDGEW------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EECK-------------------------------------------------- ------------------------------------------------------------ --EE--DDEDEGATSNRAKRRSG------------------------------------- ----------------QRKD---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLDKSSSWVCVDVEH-G-VEVPHLCSQNATAPLTYV VAVDGDGFLKDLGRKYDPTWMTASRKRRVDDEWWEDTLEPFMGPEDERDKKEEKEL-QSK LLNKPMPTSIAEYKNHPLYALKRHLLKYEALYPPTAAVLGYCRGEPVYS--RDCVHTLHS RETWLKEARTVRLGEEPYKMVKGFSNRSRKARMMS-EMKDENDLPLFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKACMIPVGCVHLRLPNLH RVAKKLDLDAAPAVT-----GFDYHGGYSHAVTDGYIVCEEDEEVLRAAWVVEQEIQKRK EKEKKEKRAIASWTLLVKGLLIRERLKQRY----------SQKSQSLGS----------- ------------------------------IAPGEEAGGFSSD-ED--GVEVDPP----- ------------AAKT--ASETLALSWPQNRQ--------------------A--E-EDA GPGKQKKK----KT---TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEKHLFPFEK-V >ENSPREP00000019514 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------KL-------------------- --------------------------------ERKV------------------------ ------------------NP----------------------------KPR--------- --------MP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S------ ------------------------------------------------KRAAQNKSSPTT NT---------------------------------------------------------- ------------------------------------------------------------ ----------------SS-----------------DSKTSKYFQ--S------------- -----------------------------------------------PS----------- ---------------------------------------KEEV--K-----------SE- ----------------------------------------------DDFEMPTAAPP--- -------------------------------------------------VV--------K K------STKKP-------------EE--------------------------------- ------------------------------------------------------------ -----------------------------------------------------EE-EKEE ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -D----DS-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPAETP-EPVLPSQP----VEIEIETAEV----RKQ-------------KKRQAEF ETYLRRMMKRFKKDLVIDTHKVHLLCLLANGMFRNRLCSEPDLLAVALSLLPPHFC---- --TVARQRIDQNYLSGLLKW----------FSATFTLDPSLPTEERP-----DPQALLER RLGSLSARDHQEMTH--------------------------------------------- ---------------------------------LFLLFLRSLQLFCRLVLSLHPVPFKPP S--------------------------------------SKV------------------ -------------------------------------IDT-------------------- ------------------------------------------------------------ -PER-------------------------------------------------------- ------------------------------------------------------------ -----------------CQSS--------------------------------------- ------------------------------------------------------------ ---------------------------QES------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --SNSPEAKVS--------PG----------------TK--------------------R PA------------------------QGEKVKGSS------------------------- ------------------------------GGKK-------------------------- -E-KPVLSGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESNS--- ----------------------------------------------------------EA DE-E------------------------------------------EEEEASD------- -----AEK------------------------------------------------YQ-- ----ESS---------EDD---FESSTKPERKRTGNRK---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SSEKTSRTQG-------- -----------W------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EEGK-------------------------------------------------- ------------------------------------------------------------ --EE--DDEDEGATSNRVKRRSG------------------------------------- ----------------QRKD---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLDKSSAWVCIDVEH-G-VGVPHLCSQNATAPLTYV VAVDGDGFLKDLGRKYDPTWMTASRKRRVDDEWWEDTLEPFLGPEDERDKREEKEL-QSK LLNKPMPTSIAEYKNHPLYALKRHLLKYEALYPPTAAVLGYCRGEPVYS--RDCVHTLHS RETWLKEARTVRLGEEPYKMVKGFSNRSRKARMMS-EMKNVNDLPLFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYMFKACMIPVGCVHLRLPNLH RVARKLDLDAAPAVT-----GFDCHGGYSHAVTDGYIVCEEDEEVLRAAWVEEQEIQKQK EKEKKEKRAIASWTLLVKGLLIRERLKQRY----------SQRSQGLGS----------- ------------------------------LAPGEEAGGFSSD-ED--GVEVDSP----- ------------AAKT--ASETLVLSWPQNRQ--------------------A--E-EDA GPGKQKKK----KT---TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEKHLFPFEK-V >ENSCVAP00000011449 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRRQC-------------------------AET--------------- ------------------------------------------------------------ ---------------KANT----------------KKPKQLLSAESRG-AKTRS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KQKDPESESA--------- ----------------------------------EKEEKL-------------------- --------------------------------ERKV------------------------ ------------------KP----------------------------KSR--------- --------LS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S------ ------------------------------------------------KR---------- ---SAGKK-------------------------------------PSS------------ ----TNDASADG------------------KTTK------------VKE----------- ------------SI---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KKP--------------E--------------------------------- ------------------------------------------------------------ -----------------------------------------------------EE-EKQE ------------------------------------------------------------ ------------------------------------------------------------ ----EDD----------------------------------------------------- ------------------------------------------------------------ -D----DS-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------DEP--------------------------- L---GPVEPP-EPILPSQP----VEIEIETAEV----RKQ-------------KKRKAEF ETYLRRMMKRYKKDLLIDTHKVHLLCLLANGMFRNRLCSEPDLLAVALSLLPPHFC---- --KVAKERIDHNYLCGLLKW----------FRATFTLNPSLPTEERP-----DPQALLER RLGSLSARDHQEMTH--------------------------------------------- ---------------------------------LFLLFLRSLQLFCRLVLSLHPVPFKPP P--------------------------------------AK------------------- ------------------------------------------------SK---------- -----------------------------------------------------GTRASTS APGG-------------------------------------------------------- ------------------------------------------------------------ -----------------GQTS--------------------------------------- ------------------------------------------------------------ ---------------------------QES------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --TNSPETKVS--------PG----------------TK--------------------R PA------------------------GGGKVKGSS------------------------- ------------------------------GGKKAKRTEMK----------------QEE EE-RPVLSGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSIASKVSYKEESNS--- ----------------------------------------------------------EG G---------------------------------------------EEEEISD------- -----AEE------------------------------------------------FQ-- ----ETS---------EDDSEDFETTFRPAKRKTGNGKSATKKTKTP------------- ----------------------------------------------------------KR NSSG-----------------------------------------------------GKR Q------------------VKE-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------EDSELEDGEEENEDDGPKSDRR ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------KRRSG------------------------------------- ----------------QKKE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLDKTSSWVCVDVEH-G-VGAPQLCSQNATAPLTYV VAVDGDGRLKDLGRKYDPTWMTTSRKRRVDDEWWEETLEPFMGPEDERDKKEEKEL-QKK LLNKPLPISIAEYKNHPLYALKRHLLKYEALYPPTASVLGYCRGEPVYS--RDCVHTLHS RETWLKEARTVRLGEEPYKMVKGFSNRSRKARMMS-EMKDENDLPLFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKACMIPVGCVHLRLPNLH RVARKLNLDAAPAVT-----GFDYHGGYSHAVTDGYIVCEEDEEVLRAAWVEEQEIQRQK EKEKKEKRAIASWTLLVKGLLIRERLKRRY----------NQKNQGLGS----------- ------------------------------LGAEGDAEGFSSD-EE--GVEVEPS----- ------------GGKT--ATEALALSWPQNRQ--------------------A--E-EDG SSGKP--K----RR---TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQDKHLFPFEK-V >ENSKMAP00000003546 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRKKC-------------------------AETD--E----------- ------------------------------------------------------------ --------------EQADT----------------KKLKQPVKRESRG-AKTRA------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KKKDTVNDIT--------- ----------------------------------DNEEKL-------------------- --------------------------------ERKV------------------------ ------------------KP----------------------------KSR--------- --------LS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S------ ------------------------------------------------KRAAESNSASSA NT---------------------------------------------------------- ------------------------------------------------------------ ----------------RT-----------------GVKSSKYFS--S------------- -----------------------------------------------PV----------- ---------------------------------------KEEV--E-----------SE- ----------------------------------------------DDFDMVTSAPP--- -------------------------------------------------VVDVSAKKEDG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -D----ES-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPVEPP-EPVLPSQP----VEIEIETAEV----RKQ-------------KKRQAEF ETYLRRMVKRYKKDQLIDTHKVHLMCLIANGIFRNRLCSKPDLLAITLSLLPSHFC---- --NVAKERIDQNYLSGLLKW----------FRATFTLNPSLPYEECP-----DPQALLER RLASISARDHQEMTH--------------------------------------------- ---------------------------------IFLLILRSLQLFCRLVLSLQPVPFKPP S--------------------------------------AK------------------- ------------------------------------------------CK---------- -----------------------------------------------------GTRKSTA APKR-------------------------------------------------------- ------------------------------------------------------------ -----------------CRKS--------------------------------------- ------------------------------------------------------------ ---------------------------QET------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --TNSAEPKVS--------PG----------------TK--------------------R PS------------------------GGGKGRGSS------------------------- ------------------------------GGKKSKRKEMQ----------------EEK EE-KPVFSGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESNS--- ----------------------------------------------------------EG NDGD------------------------------------------EEEELSD------- -----AEE------------------------------------------------FQ-- ----ATS---------EDSSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSESEVKSTKVK--------------------KGKVQS- ----------KANAG--------------------------------------------- -------------NNKNTTASKGKSGG--------------------------------- -----------------------RKQ--------EKSEEDSELEEG-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KE--DDEDEGATSNKTKGQSR------------------------------------- ----------------RSGD---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLDKTSSWVCVDVQH-G-VGMSHLCSQNATAPVTYV IAVDGNGFLKDLGRKYDPTWMTLSRKRRVDDEWWEETLEPFLGPKDERDKMEEKEL-QNK LLNKPMPVSVAEFKNHPLYALKRHLLKYEALYPPTAAVLGYCRGEPVYS--RDCVHTLHS RETWLKEARTVRLGEEPFKMVKGFSNRSRKARMMS-ETKDEKDLPLFGEWQTEAYQPPIA VDGK--------------------------VPRNEYGNVYLFKACMIPVGCVHVRLPNLH RVARKLNLDAAPAVT-----GFDYHGGYSHAVTDGYIVCEEDEEILRAAWVEEQEIQKQK EKEKKEKRAVAHWTLLVKGLLIRERLKRRY----------NKKPQGLGS----------- ------------------------------LAQGGDAGGFSSD-EE--VIEGDTS----- ------------GAKT--ATETLAMSWPQNRQ--------------------A--E-EDD GSTSR-SK----KK---TTKRG-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKSQEQHLFPFEK-V >ENSATEP00000009915 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRRES-------------------------AET--------------- ------------------------------------------------------------ ---------------EADT----------------KRVKQVKKAGSSGPSKTRA------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------TSKDAGNDIT--------- ----------------------------------EKEEKL-------------------- --------------------------------ERKV------------------------ ------------------KP----------------------------KSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------SSAKRAGGNTSSTTAASTIAVKTSKYFQ--S------------- -----------------------------------------------PV----------- --------------------------------------KKEET--D-----------SE- ----------------------------------------------DDFDMVTSAAP--- ------------------------------------------------------------ ---VITVNAQKP-------------EK--------------------------------- ------------------------------------------------------------ ---------------------------------------------------------EEE ------------------------------------------------------------ ------------------------------------------------------------ ----EDE----------------------------------------------------- ------------------------------------------------------------ -D----SE-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPVEPP-EPALPSQP----VEIEIETPEI----RKR-------------KKKQAEL ETYLRRMVNRYKKDVLIDTHKVHLMCLIASGMFRNRLCSKPDLLAITLSLLPSNFC---- --MIDKERIDQNYLSELLKW----------FRAAFTLNPCLPCEERP-----DPQTLLER RLTSLSAKNHQEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPIPLKPP S--------------------------------------AK------------------- ------------------------------------------------GK---------- -----------------------------------------------------GDKTSAG AQGK-------------------------------------------------------- ------------------------------------------------------------ -----------------SHKA--------------------------------------- ------------------------------------------------------------ ---------------------------KET------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --ATSLEPKVS--------PG----------------TK--------------------R PA------------------------GGCTAKGAR------------------------- ------------------------------GGKKPKKKEIREE-------------DEEE DE-KTLTSAGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVRYKEESTS--- ----------------------------------------------------------EQ E---------------------------------------------E--DLSD------- -----DEE------------------------------------------------FQ-- ----VAS---------EEDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSEGEAKSTKRKV------------------VK------ ------------------------------------------GKR--------------- -----KAKGTN------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------KKKAG--------------------------------- ------------------AP---------------------------------------- ------------------------------------------------------------ ------------------------K----------------------------------- --------------------RRSGGGKKKIK----------------------------- ------------------------------------------------------------ -----------------DEE-DKDW----------------------------------- EEEEGSDEEGEETTNNITERRSG------------------------------------- ----------------KNKD---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLEKTSSWVCVDVEQ-G-VGVPHLCYKNATVPVTYV VSVDGDGFVKDLGKKYDPTWMTSSRKRRVDEDWWEETLEPFLGPEDDRDLKEDKEL-QNK LLNKPMPVSIAEYKNHPLYALKRHLLKYEAIYPETATVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMVS-EMKDENDLALFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHLRLPNLH RVARKLDLDAAPAVT-----GFDFHGGYSHAVTDGYIVCEEHEEVLRAAWVEEQELQKQK EKEKREKRAISNWTLLVKGLLIRERLKQRY----------SKKNHGVGN----------- ------------------------------LACDEDTGGLSSD-EE--VVEGECS----- ------------GSKT--ASETLAMSWPQNRQ--------------------A--E-EDG GSASGLKK----KT---TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEKHLFPFEK-V >ENSMAMP00000023641 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ETEDKL-------------------- --------------------------------ERKV------------------------ ------------------KP----------------------------RSRYSTRQAAGI TSSSASTNI--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -T---------------------------------------------------------- ------------------------------------------------------------ -----------------------------------AVKTSKYFQ--S------------- -----------------------------------------------PA----------- --------------------------------------KEEET--H-----------SE- ----------------------------------------------DDFDMETSAKP--- ------------------------------------------------------------ ---VVTVNTREP-------------EKE-------------------------------- ------------------------------------------------------------ ------------------------------------------------------E-EEEE ------------------------------------------------------------ ------------------------------------------------------------ ----EDE----------------------------------------------------- ------------------------------------------------------------ -D----SE-------------EDEG-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPVEPP-EPILPSQP----VEIEIETPEV----RKK-------------QKKQAEF ETYLRRMMNRYKKDVLEDTHKVHLMCLIASGMFRNRLCSEPDLLAVTLSLVPARFT---- --IVAKERMDENYLSGLLKW----------CVATFTLNPSLPCEERP-----DPQALLER RLASLSARNHQEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPIPLKPP SGARTSAGTSGKSDTSQ--------------KTSETNSP--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EPKVS--------PG----------------TK--------------------R PA------------------------GSRESKGAR------------------------- ------------------------------GGKKAKKKEVKEE-------------DEDE EE-NAVISGRQK-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NL----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESNS--- ----------------------------------------------------------EG E---------------------------------------------E--GLTD------- -----EEE------------------------------------------------FQ-- ----LTS---------EEASE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSEGEDKSTKEK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------RRSGGTKKQVKEDKDCEDEEDSDE----------------G EKVQNNRTKQRS---AKKMD---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GNDEWLEVYLQTGSSWVCMDVEH-G-VGMPHLCSENATAPVTYV VSVDGDGFVKDLGRRYDPTWMTSSRKRRVDEDWWEETLEPFLGPEDNRDIKEDKEL-QNK LLNKPLPVSIVEYKNHPLYALKRHLLKYEAIYPPTAAVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMMS-ELKNENDLPLFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHIRLPNLH RVAKKLNMEAAPAVT-----GFDFHGGYSHAVTDGYIVCEEHEEVLRAAWVEEQELQKQK EKEKKEKRAVSNWTLLVKGLLIRERLKQRY----------SKKNQGLGS----------- ------------------------------LAHGGDTAGFSSD-EE--VVEGGSP----- ------------GAKT--ASETLAMSWPQNRQ--------------------T--E-EEG GSSNRLKK----K----TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGQEKHLFPFEK-V >ENSACIP00000021625 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------FSFIISQAQRLKN IFPSVYPGEDIAEKEEKLERKVIPKPRL-------------------------------- ----------------------------------------------------PS------ ------------------------------------------------KRAAXNTLSSKS DT---------------------------------------------------------- ------------------------------------------------------------ ----------------ST-----------------TVKASKYFQ--S------------- -----------------------------------------------PV----------- ---------------------------------------KEEN--D-----------SE- ----------------------------------------------DDFDMATSPPP--- ------------------------------------------------------------ ---LVRVNTKKP-------------EK--------------------------------- ------------------------------------------------------------ -----------------------------------------------------------E ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -E----SE-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPVDPL-EPVLPSQP----VEIEIETPEV----RKK-------------RKKQAEL ETYLRRMVNRYKKDLLIDTHKVHLMCLIASGMFRNRLCSEPDLLAVTLSLLPAHFT---- --MVAKERIDQSYLSGLLKW----------CVATFTLNPSLPCEERP-----DPRALLEK RLASVSARNHQEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPVPLKPP S--------------------------------------A-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---KV------------------------------------------------------- ------------------------------------------------------------ ---------------LTSNTS--------------------------------------- ------------------------------------------------------------ ---------------------------KES------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --TNSPEPKIS--------PG----------------TK--------------------R PA------------------------GGRKIKGDV------------------------- ------------------------------GGKK-------------------------- -K-RAVVSGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESNS--- ----------------------------------------------------------EG E---------------------------------------------EEEGLSD------- -----EDE------------------------------------------------FQ-- ----ASS---------ENDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSESGVKSTK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GKKGK----------GK----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DGEWE---------------------------------- EGKE--EEEEEGTTSKGTKRRSG------------------------------------- ----------------PKKE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVFLEKTSSWVCVDVDH-G-VGMPHLCSQNATSPVTYV VSVDGDGFVKDLGKKYDHTWMTSSRKRRVDDDWWEETLQPFLGPEDERDIKEDKEL-QNK LLNKPMPVSVAEYKNHPLYALKRHLLKYEAVYPPTATVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMMS-ELKDENDLSLFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHIRLPNLH RVARKLNLDAAPAVT-----GFDFHGGYSHAVTDGYIVCEEHEEILRAAWVEEQELQKQK EKEKKEKRAISNWTLLVKGLLIRERLKQRY----------NKKNQGLGS----------- ------------------------------LADGGDTGGFSSD-EE--AVEGGSP----- ------------GAKT--ASETLAMSWPQNRQ--------------------A--E-EDS GSASGLKR----K-----TKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEQHLFPFEK-V >ENSACLP00000027375 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------FCI---------DVFSFILSQAQRLQN IFQSVLPGEDIKDKEEKIERKVIPKPRA-------------------------------- ----------------------------------------------------PS------ ------------------------------------------------KRAAGNKLSSQS DT---------------------------------------------------------- ------------------------------------------------------------ ----------------SS-----------------AVNTSKYFE--S------------- -----------------------------------------------PI----------- ---------------------------------------MEEN--D-----------SE- ----------------------------------------------DDFDMVTSPPR--- ------------------------------------------------------------ ----LKVNTKKP-------------EK--------------------------------- ------------------------------------------------------------ -----------------------------------------------------------E ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -EGEDSEE-------------EDED-DWEEVE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GKCKIRNICNNTLQKKQAEL ETYLRRMVNRYKKDLLIDTHKVHLMCLIASAMFRNRLCSEPDLLAITLSLLPAHFT---- --MAAK-RIDQNYLSGLLKW----------FRATFTLNSSLPCEEVP-----DPQRLLER RLASLSARNHEEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPIPF--- ----------------------------------------K------------------- ------------------------------------------------AK---------- -----------------------------------------------------GARTSAG APEK-------------------------------------------------------- ------------------------------------------------------------ -----------------SNTS--------------------------------------- ------------------------------------------------------------ ---------------------------KES------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --TNSPEPKIS--------PG----------------TK--------------------R PA------------------------GGRTIKGDV------------------------- ------------------------------GGKKAKKKE---K-------------DEEE EK-KVVVSGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESNS--- ----------------------------------------------------------EG E---------------------------------------------EDGGLSD------- -----EDE------------------------------------------------FQ-- ----ATS---------EDDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSESGVKSKK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GNKGK----------G------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------RRSSGGKKQVK----------------------------- ------------------------------------------------------------ -----------------DEE-DGDL----------------------------------- EEEE--EEGGEGTTSNGTKRRSG------------------------------------- ----------------AKRE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLEKTASWVCVDVDH-G-VGVPQLCYRNATTPVTYV VSVDGDGFVKDLGKKYDPTWMTSSRKRRVDDDWWEETLEPFLGPEDEKDIKEDKEL-QKT LLNKPLPVSVAEYKNHPLYALKRHLLKYEAIYPPTATVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMTS-ELKDENDLALFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHIRLPNLH RVARKLNIDAAPAVT-----GFDFHGGYSHAVTDGYIACEEHEEVLRAAWVEEQELQKQK EKEKKEKRAISNWTLLVKGLLIRERLKKRY----------NKKNQGLGS----------- ------------------------------LAHGGDAEGFSSD-EE--AAEGESP----- ------------GAKT--ASETLAMSWPQNRQ--------------------A--E-EDG GNASGLKK----KK---VTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEQHLFPFEK-V >ENSHBUP00000002933 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------FCI---------DVFSFILSQAQRLQN IFQSVLPGEDIKDKEEKIERKVIPKPRA-------------------------------- ----------------------------------------------------PS------ ------------------------------------------------KRAAGNKLSSQS DT---------------------------------------------------------- ------------------------------------------------------------ ----------------SS-----------------AVNTSKYFE--S------------- -----------------------------------------------PI----------- ---------------------------------------MEEN--D-----------SE- ----------------------------------------------DDFDMVTSPPR--- ------------------------------------------------------------ ----LKVNTKKP-------------EK--------------------------------- ------------------------------------------------------------ -----------------------------------------------------------E ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -EGEDSEE-------------EDED-DWEEVE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GKCKIRNICNNTLQKKQAEL ETYLRRMVNRYKKDLLIDTHKVHLMCLIASAMFRNRLCSEPDLLAVTLSLLPAHFT---- --MAAK-RIDQNYLSGLLKW----------FRATFTLNSSLPCEEGP-----DPQRLLER RLASLSARNHEEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPIPF--- ----------------------------------------K------------------- ------------------------------------------------AK---------- -----------------------------------------------------GARTSAG APEK-------------------------------------------------------- ------------------------------------------------------------ -----------------SNTS--------------------------------------- ------------------------------------------------------------ ---------------------------KES------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --TNSPEPKIS--------PG----------------TK--------------------R PA------------------------GGRTIKGDV------------------------- ------------------------------GGKKAKKKE---K-------------DEEE EK-KVVVSGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESNS--- ----------------------------------------------------------EG E---------------------------------------------EDGGLSD------- -----EDE------------------------------------------------FQ-- ----ATS---------EDDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSESGVKSKK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GNKGK----------G------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------RRSSGGKKQVK----------------------------- ------------------------------------------------------------ -----------------DEE-DGDL----------------------------------- EEEE--EEGGEGTTSNGTKRRSG------------------------------------- ----------------AKRE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLEKTASWVCVDVDH-G-VGVPQLCYRNATTPVTYV VSVDGDGFVKDLGKKYDPTWMTSSRKRRVDDDWWEETLEPFLGPEDEKDIKEDKEL-QKT LLNKPLPVSVAEYKNHPLYALKRHLLKYEAIYPPTATVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMTS-ELKDENDLALFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHIRLPNLH RVARKLNIDAAPAVTDDSED------------TDGYIACEEHEEVLRAAWVEEQELQKQK EKEKKEKRAISNWTLLVKGLLIRERLKKRY----------NKKNQGLGS----------- ------------------------------LAHGGDAEGFSSD-EE--AAEGESP----- ------------GAKT--ASETLAMSWPQNRQ--------------------A--E-EDG GNASGLKK----KK---VTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEQHLFPFEK-V >ENSNBRP00000030239 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------FCI---------DVFSFILSQAQRLQN ILQSVLPGEDIKDKEEKIERKVIPKPHA-------------------------------- ----------------------------------------------------PS------ ------------------------------------------------KRAAGNKLSSQS DT---------------------------------------------------------- ------------------------------------------------------------ ----------------SS-----------------AVNTSKYFE--S------------- -----------------------------------------------PI----------- ---------------------------------------MEEN--D-----------SE- ----------------------------------------------DDFDMVTSPPR--- ------------------------------------------------------------ ----LKVNTKKP-------------EK--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -EGEDSEE-------------EDED-DWEEVE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GKCKIRNICNNTVQKKQAEL ETYLRRMVNRYKKDLLIDTHKVHLMCLIASGMFRNRLCSKPDLLAITLSLLPAHFT---- --MVAK-RIDQNYLSGLLKW----------FRATFTLNSSLPCEERP-----DPQRLLER RLASLSARNHEEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPIPF--- ----------------------------------------K------------------- ------------------------------------------------AK---------- -----------------------------------------------------GARTSAG APEK-------------------------------------------------------- ------------------------------------------------------------ -----------------SNTS--------------------------------------- ------------------------------------------------------------ ---------------------------KES------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --TNSPEPKIS--------PG----------------TK--------------------R PA------------------------GGRTIKGDV------------------------- ------------------------------GGKKAKKKE---K-------------DEEE EK-KVVVSGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESNS--- ----------------------------------------------------------EG E---------------------------------------------EDGGLSD------- -----EDE------------------------------------------------FQ-- ----ATS---------EDDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSESGVKSKK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GN--K----------G------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------RRSRGGKKQVK----------------------------- ------------------------------------------------------------ -----------------DEE-DEDL----------------------------------- EEEE--EEGGEGTTSNGTKRRSG------------------------------------- ----------------AKRE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLEKTASWVCVDVDH-G-VGVPQLCYRNATTPVTYV VSVDGDGFVKDLGKKYDPTWMTSSRKRRVDDDWWEETLEPFLGPEDEKDIKEDKEL-QKT LLNKPLPVSVVEYKNHPLYALKRHLLKYEAIYPPTATVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMTS-ELKDENDLALFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHIRLTNLH RVARKLNIDAAPAVT-----GFDFHGGYSHAVTDGYIACEEHEEILRAAWVEEQELQKQK EKEKKEKRAISNWTLLVKGLLIRERLKKRY----------NKKNQGLGS----------- ------------------------------LAHGGDAEGFSSD-EE--AAEGESP----- ------------GAKT--ASETLAMSWPQNRQ--------------------A--E-EDG GNASGLKK----KK---VTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEQHLFPFEK-V >ENSPNYP00000014334 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------FCI---------DVFSFILSQAQRLQN IFQSVLPGEDIKDKEEKIERKVIPKPRA-------------------------------- ----------------------------------------------------PS------ ------------------------------------------------KRAAGNKLSSQS DT---------------------------------------------------------- ------------------------------------------------------------ ----------------SS-----------------AVNTSKYFE--S------------- -----------------------------------------------PI----------- ---------------------------------------MEEN--D-----------SE- ----------------------------------------------DDFDMVTSPPR--- ------------------------------------------------------------ ----LKVNTKKP-------------EK--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----EE----------------------------------------------------- ------------------------------------------------------------ -EGEDSEE-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPLEPL-EPVLPSEP----VEIEIETPEV----RKR-------------QKKQAEL ETYLRRMVNRYKKDLLIDTHKVHLMCLIASAMFRNRLCSEPDLLAVTLSLLPAHFT---- --MAAK-RIDQNYLSGLLKW----------FRATFTLNSSLPCEEGP-----DPQRLLER RLASLSARNHEEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPIPF--- ----------------------------------------K------------------- ------------------------------------------------AK---------- -----------------------------------------------------GARTSAG APEK-------------------------------------------------------- ------------------------------------------------------------ -----------------SNTS--------------------------------------- ------------------------------------------------------------ ---------------------------KES------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --TNSPEPKIS--------PG----------------TK--------------------R PA------------------------GGRTIKGDV------------------------- ------------------------------GGKKAKKKE---K-------------DEEE EK-KVVVSGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESNS--- ----------------------------------------------------------EG E---------------------------------------------EDGGLSD------- -----EDE------------------------------------------------FQ-- ----ATS---------EDDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSESGVKSKK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GNKGK----------G------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------RRSSGGKKQVK----------------------------- ------------------------------------------------------------ -----------------DEE-DGDL----------------------------------- EEEE--EEGGEGTTSNGTKRRSG------------------------------------- ----------------AKRE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLEKTASWVCVDVDH-G-VGVPQLCYRNATTPVIYV VSVDGDGFVKDLGKKYDPTWMTSSRKRRVDDDWWEETLEPFLGPEDEKDIKEDKEL-QKT LLNKPLPVSVAEYKNHPLYALKRHLLKYEAIYPPTATVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMTS-ELKDENDLALFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHIRLPNLH RVARKLNIDAAPAVTDDSED------------TDGYIACEEHEEVLRAAWVEEQELQKQK EKEKKEKRAISNWTLLVKGLLIRERLKKRY----------NKKNQGLGS----------- ------------------------------LAHGGDAEGFSSD-EE--AAEGESP----- ------------GAKT--ASETLAMSWPQNRQ--------------------A--E-EDG GNASGLKK----KK---VTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEQHLFPFEK-V >ENSONIP00000002110 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RRREC-------------------------ANT--------------- ------------------------------------------------------------ ---------------GGDT----------------KKLKQVLKAKSSG-AKTRA------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KKKD--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------A--------------------------- -------GEDITDKEEKIERKVIPKPRV-------------------------------- ----------------------------------------------------PS------ ------------------------------------------------KRAAGNKLSSQS DT---------------------------------------------------------- ------------------------------------------------------------ ----------------GS-----------------AVNTSKYFE--S------------- -----------------------------------------------PI----------- ---------------------------------------MEEN--D-----------SE- ----------------------------------------------DDFDMVTSPPR--- ------------------------------------------------------------ ---LLKVNTKKP-------------EK--------------------------------- ------------------------------------------------------------ -----------------------------------------------------------E ------------------------------------------------------------ ------------------------------------------------------------ ----EEG----------------------------------------------------- ------------------------------------------------------------ -VGEDSEE-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPLEPL-EPVLPSEP----VEIEIETPEV----RKR-------------RKKQAEL ETYLRRMVNRYKKDLLIDTHKVHLMCLIASGMFRNRLCSEPDLLAITLSLLPAHFT---- --MVAKDRIDQNYLSGLLKW----------FRATFTLNSSLHCEERP-----DPQRLLER RLASLSARNHEEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPIPFKAP S--------------------------------------AK------------------- ------------------------------------------------AK---------- -----------------------------------------------------GARTSAG APEK-------------------------------------------------------- ------------------------------------------------------------ -----------------SNTS--------------------------------------- ------------------------------------------------------------ ---------------------------KES------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --TNSPEPKIS--------PG----------------TK--------------------R PA------------------------GGRKIKGDV------------------------- ------------------------------GGKKAKKKE---K-------------DEEE EK-KVVVSGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESNS--- ----------------------------------------------------------EG E---------------------------------------------EEGGLSD------- -----EDE------------------------------------------------FQ-- ----ATS---------EDDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSESGVKSKK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GN--K----------GKAKG--T----------- -----HSK-------NTAAP---------------------------------------- ------------------------------------------------------------ ------------------------K----------------------------------- --------------------RRSSGGKKQVK----------------------------- ------------------------------------------------------------ -----------------DEE-DGDWE---------------------------------- EEEE--E--GEGTTSNGTKRRSG------------------------------------- ----------------AKRE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLEKTSSWVCVDVDH-G-VGVPQLCYRNATTPVTYV VSVDGDGFVKDLGKKYDPTWMTSSRKRRVDDDWWEETIEPFLGPEDEKDIKEDKEL-QKT LLNKPLPVSVAEYKNHPLYALKRHLLKYEAIYPPTATVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMMS-ELKDENDLALFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHIRLPNLH RVARKLNIDAAPAVT-----GFDFHGGYSHAVTDGYIACEEHEEVLRAAWVEEQELQKQK EKEKKEKRAISNWTLLVKGLLIRERLKKRY----------NKKNQGLGS----------- ------------------------------LAHGGDAEGFSSD-EE--AAEVESP----- ------------GAKT--ASETLAMSWPQNRQ--------------------A--E-EDG GNAGGLKK----KK---VTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEQHLFPFEK-V >ENSMZEP00005028360 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------RRREC-------------------------ANT--------------- ------------------------------------------------------------ ---------------GGDT----------------KKLKQVLKAKSCG-AKTRA------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KKKN--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------A--------------------------- -------GEDIKDKEEKIERKVIPKPRA-------------------------------- ----------------------------------------------------PS------ ------------------------------------------------KRAAGNKLSSQS DT---------------------------------------------------------- ------------------------------------------------------------ ----------------SS-----------------AVNTSKYFE--S------------- -----------------------------------------------PI----------- ---------------------------------------MEEN--D-----------SE- ----------------------------------------------DDFDMVTSPPR--- ------------------------------------------------------------ ----LKVNTKKP-------------EK--------------------------------- ------------------------------------------------------------ -----------------------------------------------------------E ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -EGEDSEE-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPLEPL-EPVLPSEP----VEIEIETPEV----RKR-------------QKKQAEL ETYLRRMVNRYKKDLLIDTHKVHLMCLIASAMFRNRLCSEPDLLAITLSLLPAHFT---- --MAAK-RIDQNYLSGLLKW----------FRATFTLNSSLPCEEVP-----DPQRLLER RLASLSARNHEEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPIPFKAP S--------------------------------------AK------------------- ------------------------------------------------AK---------- -----------------------------------------------------GARTSAG APEK-------------------------------------------------------- ------------------------------------------------------------ -----------------SNTS--------------------------------------- ------------------------------------------------------------ ---------------------------KES------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --TNSPEPKIS--------PG----------------TK--------------------R PA------------------------GGRTIKGDV------------------------- ------------------------------GGKKAKKKE---K-------------DEEE EK-KVVVSGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESNS--- ----------------------------------------------------------EG E---------------------------------------------EDGGLSD------- -----EDE------------------------------------------------FQ-- ----ATS---------EDDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSESGVKSKK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GNKGK----------GKAKG--T----------- -----HSR-------NTAAP---------------------------------------- ------------------------------------------------------------ ------------------------K----------------------------------- --------------------RRSSGGKKQVK----------------------------- ------------------------------------------------------------ -----------------DEE-DGDLE---------------------------------- EEEE--EEGGEGTTSNGTKRRSG------------------------------------- ----------------AKRE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLEKTASWVCVDVDH-G-VGVPQLCYRNATTPVTYV VSVDGDGFVKDLGKKYDPTWMTSSRKRRVDDDWWEETLEPFLGPEDEKDIKEDKEL-QKT LLNKPLPVSVAEYKNHPLYALKRHLLKYEAIYPPTATVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMTS-ELKDENDLALFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHIRLPNLH RVARKLNIDAAPAVT-----GFDFHGGYSHAVTDGYIACEEHEEVLRAAWVEEQELQKQK EKEKKEKRAISNWTLLVKGLLIRERLKKRY----------NKKNQGLGS----------- ------------------------------LAHGGDAEGFSSD-EE--AAEGESP----- ------------GAKT--ASETLAMSWPQNRQ--------------------A--E-EDG GNASGLKK----KK---VTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEQHLFPFEK-V >ENSLCAP00010059700 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------S-------------------------------------------------- ------------KRRER-------------------------ADT--------------- ------------------------------------------------------------ ---------------EADT----------------KKPKQELRAKSSA-AQVRA------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KKKDAGNSIT--------- ----------------------------------EEEEKL-------------------- --------------------------------KRKV------------------------ ------------------KP----------------------------KSR--------- --------LSS------------------------------------------------- ------------------------------------------------------------ -----------------------------------K------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TTSRNNSSSKSTATTAAADVK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------TSRYFQ--S------------- -----------------------------------------------PV----------- ---------------------------------------KEEV--D-----------SE- ----------------------------------------------DDFDMGTSPP---- ------------------------------------------------------------ ----LKLNCKKLE----------KKEK--------------------------------- ------------------------------------------------------------ -----------------------------------------------------------E ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -D----SE-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPVEPP-EPALPSQP----VEIEIETPEV----RKK-------------QKRQAEF ESYLRRMMNRYKKDLLIDTHKVHLMCLIASGMFRNRLCSEPDLLAITLSLLPSHFG---- --MVAKERIDQNYLSGLLKW----------FRATFTLNPSLPYEERP-----DPQALLER RLASLSARNHEEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPIPFKPP S--------------------------------------AK------------------- ------------------------------------------------GK---------- -----------------------------------------------------GAITSTG ---K-------------------------------------------------------- ------------------------------------------------------------ -----------------SHTN--------------------------------------- ------------------------------------------------------------ ---------------------------QET------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --TTSPEPKVS--------PG----------------SK--------------------R PA------------------------GEGKAKGDR------------------------- ------------------------------GGKKAKTKEI--K-------------EEEE EE-KAITSGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVTYKEESNS--- ----------------------------------------------------------EG E---------------------------------------------E--GLS-------- -----EEE------------------------------------------------FQ-- ----VTS---------EEDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSESEANSTK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GKKGR----------GKSKAKVT----------- -----NNK-------NTAAP---------------------------------------- ------------------------------------------------------------ ------------------------K----------------------------------- --------------------RRSGGGKKQVKGKG-------------------------- ---------------------------------------------------------EEE E--------------DDDEE---------------------------------------- ---------GEGTANNGTKRRSG------------------------------------- ----------------KKKE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLEKTSSWVCVDVEH-G-VGMPHLCSQNATAPVTYV VSVDGDGFVKDLGRKYDPTWMTSSRKRRVDEEWWEETLEPLLGPEDEKDMKEDKEL-QNK LLSKPLPISITEYKDHPLYALKRHLLKYEAIYPPTATVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMMS-EQKDEKDLPLFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHLRLPNLH RVARKLDMDAAPAVT-----GFDFHGGYSHAVTDGYIVCEEHEEVLRAAWVEEQELQKQK EKEKKEKRAISNWTLLVKGLLIRERLKQRY----------GKKNQGLGS----------- ------------------------------LANGDEAGGFSSD-EE--AVEGGSP----- ------------GAKT--ASEILAMSWPQNRQ--------------------A--E-EDG GNTSGLKK----KS---MTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEKHLFPFEK-A >ENSAPEP00000021729 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRRES-------------------------QET--------------- ------------------------------------------------------------ ---------------AADT----------------KKPKQVLKAKSSA-AKPRA------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KEKDADNFIA--------- ----------------------------------EKEEKL-------------------- --------------------------------ERKV------------------------ ------------------KP----------------------------KPR--------- --------LS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S------ ------------------------------------------------KRAPEQTSSSKS ST---------------------------------------------------------- ------------------------------------------------------------ ----------------SS-----------------AVKTSKYFQ--S------------- -----------------------------------------------PV----------- ---------------------------------------KEEI--N-----------SE- ----------------------------------------------EDFDMETSPPPPMF KKK--------------------------------------------PEI------KEEE EDS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------E-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPVEPS-EPVLPSQP----VEIEIETPEV----RKR-------------QKRQAEF ETYLRRMMNRYKKDVWIDTHKVHLMCLIASGMFRNRLCSEPDLLAITLSLLPTRYS---- --NVEKGCINLSYLSLLLKW----------FRQTFTLNPSLPYEECP-----DPRALLER RLASLSARNHQELTH--------------------------------------------- ---------------------------------LFLLILRSLQLFCRLVLSLQPIPLKPP S--------------------------------------AK------------------- ------------------------------------------------GK---------- -----------------------------------------------------AAGTS-- -PPKKSQEMS-------------------------------------------------- ------------------------------------------------------------ -------------KST-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------SPKVS--------PG----------------TK--------------------R PA------------------------EGRNIK---------------------------- ------------------------------GGKKAKRKEKKKE-------------EEEE EE-KSVSSGGQK-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESNS--- ----------------------------------------------------------DG DG-D-----------------------------------------EEEERLS-------- -----EEE------------------------------------------------FQ-- ----ATS---------EEDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSERGAKSAK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GKKTK----------RKSEAKGK----------- -----NSK-------GTVAP---------------------------------------- ------------------------------------------------------------ ------------------------K----------------------------------- --------------------RKSGGGKKQIK----------------------------- ------------------------------------------------------------ -----------------DEE---------------------------------------- EEED--DDEEEGIVNNGTKK-SG------------------------------------- ----------------KKKE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GVDEWLEVYLEKTSSWVCVHVEK-G-VGMPHLCSQNATAPVTYV VSVDGDGFLKDLGRKYDPTWMTSSRKRRIDDEWWKETLEPFLGPEDERDIKEEKEL-QNK LLNKPLPISIGEYKNHPLYALKRHLLKYEAIYPPTATTLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMMA-ELKEENDLPLFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHLQLPNLH RVARKLNLDAAPAVT-----GFDFHGGYSHAVTDGYIVCEEHEEVLRAAWVEEQELQKQK EKEKKEKRAISNWTLLVKGLLIRERLKQRY----------GKKTHGLGT----------- ------------------------------LAHGDDAGGFSSD-ED--LVEDGSN----- ------------GAKT--ASETLAMSWPQNRQA-------------------A--E-EDG GSGSGLKK----K----TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGQQQHLFPFEK-V >ENSAOCP00000023226 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRRES-------------------------QET--------------- ------------------------------------------------------------ ---------------AADT----------------KKPKQVLKAKSSA-AKPRA------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KEKDADNFIV--------- ----------------------------------EKEEKL-------------------- --------------------------------ERKV------------------------ ------------------KP----------------------------KPR--------- --------LS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S------ ------------------------------------------------KRAPEQTSSSKS ST---------------------------------------------------------- ------------------------------------------------------------ ----------------SS-----------------AVKTSKYFQ--S------------- -----------------------------------------------PV----------- ---------------------------------------KEEI--N-----------SE- ----------------------------------------------EDFDMETSPPPPMF KKK--------------------------------------------PEI------KEEE EDS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------E-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPVEPS-EPVLPSQP----VEIEIETPEV----RKR-------------QKRQAEF ETYLRRMMNRYKKDVWIDTHKVHLMCLLASGMFRNRLCSEPDLLAITLSLLPTRYS---- --NVEKGCINLSYLSLLLKW----------FRQTFTLNPSLPYEECP-----DPQALLER RLASLSARNHQELTH--------------------------------------------- ---------------------------------LFLLILRSLQLFCRLVLSLQPIPLKPP S--------------------------------------AK------------------- ------------------------------------------------GK---------- -----------------------------------------------------AAGTS-- -PPKKSQEMS-------------------------------------------------- ------------------------------------------------------------ -------------KSS-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------SPKVS--------PG----------------TK--------------------R PA------------------------EGRNIK---------------------------- ------------------------------GGKKAKRKEKKEE-------------EEEE EE-KSVSSGGQK-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESNS--- ----------------------------------------------------------DG DG-D-----------------------------------------EEEERLS-------- -----EEE------------------------------------------------FQ-- ----ATS---------EEDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSERGAKSTK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GKKTK----------RKSEAKGK----------- -----NSK-------GSVAP---------------------------------------- ------------------------------------------------------------ ------------------------K----------------------------------- --------------------RKSGGGKKQIK----------------------------- ------------------------------------------------------------ -----------------DEE---------------------------------------- EEE---DDEEEGIVNNGTKK-SG------------------------------------- ----------------EKKE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GVDEWLEVYLEKTSSWVCVHVEK-G-VGMPHLCSQNATAPVTYV VSVDGDGFLKDLGRKYDPTWMTSSRKRRIDDEWWKETLEPFLGPEDERDIKEEKEL-QNK LLNKPLPISIGEYKNHPLYALKRHLLKYEAIYPPTATTLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMMA-ELKEENDLPLFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHLQLPNLH RVARKLNLDAAPAVT-----GFDFHGGYSHAVTDGYIVCEEHEEVLRAAWVEEQELQKQK EKEKKEKRAISNWTLLVKGLLIRERLKQRY----------GKKTHGLGT----------- ------------------------------LAHGDDAGGFSSD-ED--LVEDGSN----- ------------GSKT--ASETLAMSWPQNRQ--------------------A--E-EDG GSGSGLKK----K----TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGRQQHLFPFEK-V >ENSAPOP00000020706 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRRQS-------------------------QET--------------- ------------------------------------------------------------ ---------------AADK----------------RKPKQELKAKSNA-AKRRA------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KKKDADNVIA--------- ----------------------------------EKEEKL-------------------- --------------------------------ERKV------------------------ ------------------KP----------------------------KRR--------- --------LS-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S------ ------------------------------------------------KQALGQTSSSKS ST---------------------------------------------------------- ------------------------------------------------------------ ----------------SS-----------------AVKTSKYFQ--S------------- -----------------------------------------------PV----------- ---------------------------------------KEEI--D-----------SE- ----------------------------------------------EDFDMETSPPPPMF KK---------------------------------------------------------- --SA-----KKP-------------EK--------------------------------- ------------------------------------------------------------ ---------------------------------------------------------EEE ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -E----EE-------------EEED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPAEPP-EPVLPSQP----VEIEIETPEV----RKR-------------QKRQAEF ETYLRRMMNRYKKDVWIDTHKVHLMCLIASGMFRNRLCSEPDLLAITLSLLPSQYS---- --NVEKGRVDLSYLSLLLKW----------FRQTFTLNASLPNEERL-----DLRVLLER RLASFSARNHQELTH--------------------------------------------- ---------------------------------LFLLILRSLQLFCRLVLSLQPIPLKPP S--------------------------------------AK------------------- ------------------------------------------------GK---------- -----------------------------------------------------AAVTS-- -PPKKSQEMS-------------------------------------------------- ------------------------------------------------------------ -------------KST-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------SPKVS--------PG----------------TK--------------------R PA------------------------EGGKIK---------------------------- ------------------------------AGKKAKRKEK----------------EDEE EE-KSVSSGGQK-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RRVASKVNYKEESNS--- ----------------------------------------------------------DR DG-D------------------------------------------EEERLS-------- -----DEE------------------------------------------------FQ-- ----ATS---------EEDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSERGAKSTK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------AKKMK----------RKSEVKGK----------- -----NSK-------DTVVP---------------------------------------- ------------------------------------------------------------ ------------------------K----------------------------------- --------------------RKSGEGKKQIK----------------------------- ------------------------------------------------------------ -----------------DEQ---------------------------------------- EDDD--DDDDEGIVSNGTKKRNG------------------------------------- ----------------KKKE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GVDEWLEVYLEKTSSWVCVHVEK-G-VGMPHLCSQNATAPVTYV VSVDGDGFLKDLGRKYDPTWMTSSRKRRIDDEWWEETLEPFLGPEDERDIKEEKEL-QNK LLNKPLPISIGEYKNHPLYALKRHLLKYEAIYPPTATTLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMMA-ELKEENDLPLFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHVQLPNLH RVARKLNLDAAPAVT-----GFDFHGGYSHAVTDGYIVCEEHEEVLRAAWVEEQELKKQK EKEKKEKRVISNWTLLVKGLLIRERLKQRY----------GKKTHGLGT----------- ------------------------------LAHGDDTVGFSSD-ED--LVEDGSS----- ------------GAKT--ASETLAMSWPQNRQ--------------------A--E-GDG GSDSGLKK----K----TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGQQQHLFPFEK-L >ENSLCRP00005052984 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRREC-------------------------AET--------------- ------------------------------------------------------------ ---------------EADT----------------KKAKQVLKAKSSG-A--RATTA--- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RKKKDAGNDIT--------- ----------------------------------EEEENL-------------------- --------------------------------ERKV------------------------ ------------------KP----------------------------KPRST------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------T------ ------------------------------------------------KRAA-------S TT---------------------------------------------------------- ------------------------------------------------------------ ----------------ST-----------------AVKTSKYFQ--S------------- -----------------------------------------------PV----------- --------------------------------------KEEET--D-----------SE- ----------------------------------------------DDFDMVTSPPR--- ------------------------------------------------------------ -------------------------ERKG----KA-----AKKTEKEEKKEEEEEDSEED FDMLTSP----------------------------------------------------- ------------------------PRTWK-----------AK------KTEQEEE-EEEE ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -D----SD-------------EEED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TGP--------------------------- L---GPVEPP-DLVLPSQP----VEIEIETPEV----RKK-------------KKKQAEF EMYLRRMMNRYKKDLLEDTHKVHLMCLIASGMFRNRLCNEPDLLAITLSLLPTHFG---- --SVAKERIDQNYLSGLLKW----------FRATFTLNPDLSYEERP-----DLRALLER RLASLSARNHQEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPIPLKLP S--------------------------------------AK------------------- ------------------------------------------------GK---------- --------------------------------------------------------TSAG GPEK-------------------------------------------------------- ------------------------------------------------------------ -----------------SSTS--------------------------------------- ------------------------------------------------------------ ---------------------------QGT------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --NSPTEPKVS--------PG----------------TK--------------------R TA------------------------GREKTRGDR------------------------- ------------------------------GGKKAKRKEI----------------NEEE EE-KAVTSVGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSIASKVSYKEESNS--- ----------------------------------------------------------EG EK-E------------------------------------------EEEGLSD------- -----EEE------------------------------------------------YQ-- ----ATS---------EE------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------EDSAESDSGAKSTKMK QKNKTKV----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------S----------- -----NSK-------STAAP---------------------------------------- ------------------------------------------------------------ ------------------------K----------------------------------- --------------------RRSGGGKKQVK----------------------------- ------------------------------------------------------------ -----------------EEE-EEGE----------------------------------- EEEE--ENKGEGRLSNGTKRRSG------------------------------------- ----------------KKKE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADVWLEVYVEKTSSWICVDVEH-G-VGMPQLCSQNATAPVTYV ISVDGNGFLKDLGRKYDPTWMTSSRKRRVDEDWWEDTLEPFLGPDDDRDKQEDKEL-ENK LLNKPLPVSVGEYKNHPLYALKRHLLKYEAIYPPTATVLGYCRGEPVYS--RDCVHTLHS KDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMVS-EQKDQNDLPLFGEWQTEEYQPPLA VDGK--------------------------IPRNDYGNVYLFKPCMLPVGCVHLRLPNLH RVARKLDIDAAPAVT-----GFDFHGGYSHAVTDGYIVCEEHEEILRAAWVEEQELQKQK EKEKREKRVTSNWALLVKGLLIREKLKQRY----------GKKSQGL------------- -------------------------------AQEEETGGLSSD-EE--AVEGGSP----- ------------GAKT--ASETLAMSWPQNRQ--------------------A--E-EDG GSVSGLKK----KT---TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEKHLFPFEK-V >ENSSMAP00000016723 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRRRG-------------------------AET--------------- ------------------------------------------------------------ ---------------AAGT----------------K-------------------TARQV R----------------------------------------------------------- -----------------------TA-----------------------KKKKSK------ -------------------------------------SGEAKKKEAGNGIT--------- ----------------------------------EKEEKI-------------------- --------------------------------ERKI------------------------ ------------------TP----------------------------KSR--------- --------LSS------------------------------------------------- ------------------------------------------------------------ -----------------------------------KLAAKINAPSK-------------- ------------------------------------------------------------ ------------------------------------------------------------ --------STITTT---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------AVNASKYFQ--S------------- -----------------------------------------------PV----------- --------------------------------------KEEES--D-----------SD- ----------------------------------------------DDFDMVTSPAR-MF ------------------------------------------------------------ -------NATKP-------------EK--------------------------------- ------------------------------------------------------------ ----------------------------------------------------------EK ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -D----SE-------------EDED-DWEEVEGKHEFKKEFKNR---------------- ---------SPVVHILHHITLPLFCPAFFTKAIVCWQYMVCVCVCVCVCVSEL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AGP--------------------------- L---GPAEPP-EPALPSQP----LEIEIETPEV----RKK-------------QKRQAEF ETYLRRMMNKYNKDMLIDTHKVHLMCLIASGMFHNRLCSEQDLLAITLSLLPTHYG---- --MVAKERIDQNYLSGLLKW----------FRATFTLNPSLPCEERP-----DPRALLER RLASLSAKNHQEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPIPFKPP S--------------------------------------AK------------------- ------------------------------------------------GK---------- -----------------------------------------------------GARTSNC ASEK-------------------------------------------------------- ------------------------------------------------------------ -----------------TSTT--------------------------------------- ------------------------------------------------------------ ---------------------------QET------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --TTSSDTKVS--------PG----------------TK--------------------R PA------------------------AGGKAKGSR------------------------- ------------------------------GGKKAKRKDIK-----------------EE EE-SSVKSGGPR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RTVASKVSYKEESHS--- ----------------------------------------------------------EG G---------------------------------------------E--GLSD------- -----EEE------------------------------------------------FQ-- ----VTS---------DEDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSESEAESTKKE--------------------KGR---- --------------GK---------------TKVIKNKNTAVG----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GGGKKRVKDEGDN------------------------ ----EREEG------------------------------------------EDDGGVE-- ------------------------------------------------------------ ----------EGTTNNYAKRRRG------------------------------------- ----------------KKEE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLEKTSSWVCVHVEH-G-VAMPHLCSRSATAPVTYV VSVDGDGFVKDLGRKYDPTWMTSSRKRRVDEDWWDETLQPFLGPEDEKDKREEKEL-QNK LLNKPLPISIAEYKNHPLYALRRHLLKYEAIYPPTASVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGSSNRSRKARIMA-ELKDGNDLPLFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYFFKPCMLPVGCIHLRLPNLH RVAKKLEMDAAPAVT-----GFDFHGGFSHAVTDGYIVCEENEEILQAAWLEEQELQKEK EKEKREKRVISNWTLLVKGLLIRERLKQRY----------GKKNPGLGG----------- ------------------------------LAHGDNTGGLSSDEEE--AVEGGSP----- ------------GAKT--ASETLAMSWPQNRQ--------------------A--E-EDG GNSSGLTK----KS---TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGQEKHMFPFEK-V >ENSMALP00000020658 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---F-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------S-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TPVSTSAVKASKYFQ--S------------- -----------------------------------------------PV----------- --------------------------------------KEEEA--D-----------SE- ----------------------------------------------DDFDMVTSAAP--- ------------------------------------------------------------ ---VVSVNIKKE------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EE-------------EDED------------------RINKNFRQDTGLARPII ITNNYYFSLA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------R-------------KKKQAEF ETYMRRMMNRYKKDLLVDTHKVHLLCLIASGMFRNRLCGDPDLLGITLSLLPAHFS---- --MVAKERIDQNYLSGLLKW----------FVATFTLDPSLPCEECA-----DPRALLER RLTSLSARNHQEMTH--------------------------------------------- ---------------------------------LFLLALRSLQLFCRLVLSLQPIPFKPP S----------------------------------------------------------- ------------------------------------------------GK---------- -----------------------------------------------------GARTSAS ASGK-------------------------------------------------------- ------------------------------------------------------------ -----------------SHTD--------------------------------------- ------------------------------------------------------------ ---------------------------QET------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --ITSPQSKVS--------PG----------------TK--------------------R PA------------------------GGLKAKGAR------------------------- ------------------------------GGKRAKKKEIKEE-------------GEEE EE-KALTSRGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NL----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVNYKEESHS--- ----------------------------------------------------------EG E---------------------------------------------E--GLGD------- -----EEE------------------------------------------------FQ-- ----ITS---------EEDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSESEAKSTK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GKMGK----------GKSKAK------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ KNQVTAEEDKEQQEADSGEE---------------------------------------- ---------GEGTMNKRTEQRSG------------------------------------- ----------------KKKE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLEKSSSWICVDVEH-G-VRMPHLCSENATAPVTYV VSVDGDGFVKDLGRKYDPTWMTSSRKRRVDEDWWEETLEPFLGPEDERDKKEDKEL-QNK LLNKPLPTSVVEYKNHPLYALKRHMLKYEAIYPPTATVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVRGFSNRSRKARMMS-ELKDENDLALFGEWQTEQYQPPIS VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHLRLPNLH RVARKLNLDAAPAVT-----GFDFHGGYSHAVTDGYIVCEEHEEILRAAWVEEQELQKQK EREKREKRVISNWTLLVKGLLIKERLKQRY----------TKKNQSSGS----------- ------------------------------LAHGDDTTGFSSD-EE--VGEGGSP----- ------------GPKT--ASETLAMSWPQNRQ--------------------T--E-EEG VSASGLKK----DT---TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGQAKHLFPFEK-V >ENSCGOP00000034208 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRREC-------------------------A----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------AEANTKKLKQGLKA-KRSGAKARVKKET-------- ---------------------------------------------AGNGIS--------- ----------------------------------EEEEKL-------------------- --------------------------------QRKV------------------------ ------------------KP----------------------------KPRSSTKQAAGK ISSNTSTTLT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------TVKTSKYFL--S------------- -----------------------------------------------PV----------- --------------------------------------KEEET--D-----------SE- ----------------------------------------------DDSDMVTSAAP--- -------------------------------------------------VLTMNAGKT-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------EK ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -D----SE-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SGP--------------------------- L---GPVEPP-EPVLPTQP----VEIEIETPEV----RKK-------------QKRQLEF EAYLRRMMNRFKKDVLIDTHKVHLMCLIANGMFRSRLCSEPDLLAITLSLLPTHYS---- --MVAKERIDQNYLSGLLKW----------FRATFTLNPSLSWEERP-----DPRALLER RLASLSARNHQEMTH--------------------------------------------- ---------------------------------MFLLVLRSLQLFSRLVVSLQPIPLKPP S--------------------------------------AK------------------- ------------------------------------------------GK---------- -----------------------------------------------------GARTSTG APGK-------------------------------------------------------- ------------------------------------------------------------ -----------------SNTS--------------------------------------- ------------------------------------------------------------ ---------------------------QQI------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --TSS-ETKVS--------PG----------------TK--------------------R PA------------------------GGGNVKGGR------------------------- ------------------------------GGKKAKTKEKK-E-------------EEEE KG-KTITSGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSIASKVSYKDESNS--- ----------------------------------------------------------EG EK--------------------------------------------EEEELSD------- -----EEE------------------------------------------------FQ-- ----ATS---------EEDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSAGGDKSTK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RKKGK----------GKSQ--------------- ---------------NTSAP---------------------------------------- ------------------------------------------------------------ ------------------------K----------------------------------- --------------------KRNGGGQKQ------------------------------- ------EEGKE----CEEVEEKEE-----------------------GTNKA-------- ------------------------------------------------------------ ------------------KRRSG------------------------------------- ----------------KKKG---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLDKTSSWVCVDVEQ-G-VEMPHLCSQNATAPVTYV VSVDGDGFVKDLGRKYDPTWLTLSRKRRVEEDWWEETLEPFLGPEYERDKKEDKEL-QNK LLNKPLPISITEYKNHPMYALKRHLLKYEAIYPSTAAILGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMAS-EQREENDLSVFGEWQTEEYQPPLA VDGK--------------------------VPRNDYGNVYLFKSCMLPVGCVHLKLPNLH RVAKKLEMDIAPAVT-----GFDFHGGFSHAVTDGYIVCEEHEEILRAAWEEEQHLQKQK EKEKKEKRVISNWTLLVKGLLIRERLNQRY----------GKMNQGL------------- -------------------------------VQGAETAGLSSDDEE--VVEGGSP----- ------------SAKT--ASETLAMSWPQNRQ--------------------A--E-EDS GSISGLKR----KT---TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGQEKHLFPFEK-A >ENSGACP00000007550 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------TKRE-------------EK--------------------------------- ------------------------------------------------------------ ---------------------------------------------------------EQQ ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -S----EE-------------DDGD-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SGP--------------------------- L---GPVETP-EPVLPSQP----VQIEIETPEV----RKK-------------KKRQAEF ETYMRRMVNRLKKDVLVDTHKVHLLCLIANGMFRGRLCSEPDLLAITLSLLPAHFS---- --MVAKERVDQNYLSGLLKW----------FTSTFTLNASLSCEESL-----NPRALLER RLASLSARNHQEMTH--------------------------------------------- ---------------------------------LFLLVLRSLRLFCRLVISLQPIPLKTP S--------------------------------------AKV------------------ ----------------------------RQYRQKPHLVLN--------GK---------- -----------------------------------------------------GAGTSTS APGK-------------------------------------------------------- ------------------------------------------------------------ -----------------SKTS--------------------------------------- ------------------------------------------------------------ ---------------------------QQT------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --TISPEQKVS--------PG----------------TK--------------------R PA------------------------GGGAVRGGH------------------------- ------------------------------GGKKAKTEEIKEE-------------YDEI KE-KTKASGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEDSES--- ----------------------------------------------------------EG EE-EEE---------------------------------------EEEEGLS-------- -----EDD------------------------------------------------FQ-- ----ATS---------EEDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ESERGAESAK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SKKEK----------GKGKANVT----------- -----KRN-------NSAAP---------------------------------------- ------------------------------------------------------------ ------------------------K----------------------------------- --------------------RRSGGGKKQMKDEGG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ EEED--ADEEEGAAGNGTKRRSG------------------------------------- ----------------RKND---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------RADEWLEVYLVKTSSWVCVDTER-G-VGMPHLCSQNATAPITYV VSVDGDGFVKDLGRKYDPTWLTSSRKRRVDEEWWEETLQPFLGPEDERDMKEEKEL-QNK LLNKPLPVSIAEYKNHPLYALKRHLLKYEALYPSTATSLGYCRGEPVYS--RDCVHTLHS KDTWLKEARTVRLGEEPYKMVRGFSNRSRKARMAS-EQKEENDLSLFGEWQTEEYQPPLA VGGK--------------------------VPRNEYGNVYLFKPCMIPVGCVHLKLPNLH RVARKLNMDAAPAVT-----GFDFHGGYSHAVNDGYIVCEEHEEILRAAWVEDQEIQKQK EKEKKEKRVISNWTVLVKGLLIRERLKQRY----------GKKNQGLGN----------- ------------------------------L---QETCGLSSD-EE--VPEAASP----- ------------SAKT--ASETLAMSWPQNRQ--------------------AEEE-EDG GSISGLKR----KT--KTTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEKHMFPFEK-V >ENSLBEP00000010696 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRKEC-------------------------EVT--------------- ------------------------------------------------------------ ---------------QTDT----------------KK----------------------- ------------------------------------------------------------ -----------------------------------LKVLKNSGAKAR------------- ----------------------------------------AKKEDTGSDIT--------- ----------------------------------DKEEKL-------------------- --------------------------------KRKV------------------------ ------------------QP----------------------------KPRSSAK----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------KTAGNNSSSTTSSTTAAVRTSKYFQ--S------------- -----------------------------------------------PV----------- --------------------------------------KKEDS--D-----------S-- ----------------------------------------------DDFDMVTSRAP--- ------------------------------------------------------------ ----------------------------------AYKHKNAKKTENK------------- ------------------------------------------------------------ ------------------------------------------------------E-EEED ------------------------------------------------------------ ------------------------------------------------------------ ----EEE----------------------------------------------------- ------------------------------------------------------------ -D----SE-------------ESGD-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SGP--------------------------- L---GPVEPP-EPVLPSQP----VEIEIETPEV----RKR-------------QKRQAEF ENYLKRMVNRFKKDQLIDTHKVHLMCLIASGMFRNRLCSEPDLLAITLSLLPPHYA---- --MVAKERIDQNYLSGLLKW----------FKATFTLNPSLPCEERP-----DPWALLGR RLASLSAKNHQEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPIPLKAP S--------------------------------------AK------------------- ------------------------------------------------SK---------- -----------------------------------------------------G------ ---------DKSP--------ASA---------------------------------PGK SAKN-------------------------------------------------------- -----------TGKG--------------------------------------------- ------------------------------------------------------------ -----------------------------T------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --ASPSESKVS--------TG----------------TK--------------------R RA------------------------GGGKTKEDR------------------------- ------------------------------GGKKAKTNRIK----------------EED EE-KAIVSAGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSIASKVSYKEESNS--- ----------------------------------------------------------EE EK--------------------------------------------EEGGLS-------- -----DEE------------------------------------------------FQ-- ----ASS---------EEDSA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ESESGAKSTK----------------------------- -----------------------------------------IGKR--------------- ----------NVSNSKNTPASKKKSGGGINQ----------------------------- ------------------VKEEDRK----------------------------------- ------------------------------------------------------------ -----------WENEEEDEEEIK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SNTTKRRSG------------------------------------- ----------------KKKE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVFLDKTSSWVCVDVEH-G-VGMPQLCSQNATAPVTYV VSVDNNGFVKDLGRKYDPTWMTSTRKRRVDEEWWEQTLEPFVGPEDERDRKEEKEL-QNR LLNRPLPISVGEYKNHPLYALQRHLLKYEAIYPSSATVLGYCRGEPVYS--RDCVHTLHS KDTWLKEARTVRLGEEPFKMVRGFSNRSRKARMAS-ELKEEKDLPLFGEWQTEDYQPPLA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHVRLNNLH RVARKLDMDAAPAVT-----GFDFHGGYSHAVTDGYIVCEEHEEILRAAWEEDQELQKQK EKEKREKRATSNWTLLVKGLQIRERLKQRY----------GKKNQGLAC----------- ------------------------------LAQGEETGGLSSDEED--AAEDGSP----- ------------GAKT--ASETLAMSWPQNRQ--------------------A--E-EDG GSISGLKK----KT---TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGQEKHMFPFEK-V >ENSBSLP00000002717 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRREC-------------------------AET--------------- ------------------------------------------------------------ ---------------GAHT----------------KRAKQV------------------- KR-----------------------------------------------TGSGGTRKARA RE--------------------DDA----------------------------------- ------------------------------------------------------------ ----------------------------------EEEEKL-------------------- --------------------------------ARKV------------------------ ------------------QP----------------------------KSRSSTKLAA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------V----------NASSTSPAKTAAVKTSKYFQ--S------------- -----------------------------------------------SM----------- ---------------------------------------EEET--D-----------SE- ----------------------------------------------DD------------ --KTSA---APVFTGK----------------------------TGIP------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------D ------------------------------------------------------------ ------------------------------------------------------------ ----EVE----------------------------------------------------- ------------------------------------------------------------ -D----SE-------------EEDD-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TEP--------------------------- L---GPVE-P-EPALPSQP----VEIEIETPEM----RKR------YISD---YKKQAEF ETYLRRMVNRYKKDLLIDTHKVHLLCLLASGMFHSRLCSEPDLLAVTLSLLPAHFC---- --AVDKDRIDQNYLSGLLKW----------FRATFTLNPSLPCDELP-----DPRSRLER RLASLSAKTYTEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPISFKPP S--------------------------------------TKVLTV--------------- --------------------QVPPNETPT------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----PELKAS--------PG----------------SK--------------------R PA------------------------GGSSAKGAR------------------------- ------------------------------GGKKPKKKEIKAE-------------DDEE EV-KVKASTGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESDS--- ----------------------------------------------------------AG E------------------------------------------------AMSD------- -----DDD------------------------------------------------FQ-- ----ATS---------GEESE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSEGEAKSRK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GKTGT----------SKSKVKV------------ -----NNK-------NTAAP---------------------------------------- ------------------------------------------------------------ ------------------------K----------------------------------- --------------------KRNSGGSKNVK----------------------------- ------------------------------------------------------------ -----------------EEE-DQTWE---------------------------------- EGEE--SDGEEGVAETKTERRRG------------------------------------- ----------------RKKE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------R---------- ------------------------------------------------------------ ----------------GADEWLEVYVEKTSSWVCVNVEH-G-VGVPQLCFKNATAPVTYV VSVDGEGFVKDLGRKYDPNWMTSSRRRRVDEDWWEETLAPFLGPEDERSKREEKEL-QHK LLNKPMPISIAEYKNHPLYALKRHLLKYEAIYPPTATVLGYCRGEPVYS--RDCVHTLHS SDTWLKEARTVRLGEEPYKMVRGFSNRSRKARMMS-EMKEENDLALFGEWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHLRLPNLN RVARKLDLDAAPAVT-----GFDFHGGYSHAVTDGYIVCEEHEEVLRAAWVEEQELQKQK EKEKREKKAISNWTLLVKSLLIRERLKQRY----------GKNNHGLGS----------- ------------------------------AAHSEDAGGLSSD-EE--VAEA-------- ------------GSKT--ASETLAMSWPQNRQ--------------------A--E-EVG GSPTGLKT----KT---PTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGQEKHLFPFEK-V >ENSPRNP00000001429 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRRDC-------------------------AETPAVS----------- ------------------------------------------------------------ -----------------------------------KKLKQVLKAKSSG------------ ------------------------------------------------------------ -------------------------------------------GKAA------------- ----------------------------------------AKKKGAGDDDT--------- ----------------------------------EKEEKL-------------------- --------------------------------KRKV------------------------ ------------------HP----------------------------KPRKS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------S------ ------------------------------------------------KAAAGNTASLQS DT---------------------------------------------------------- ------------------------------------------------------------ ----------------ST-----------------AVTTSKYFQ--S------------- -----------------------------------------------PP----------- ---------------------------------------KEEP--E-----------SE- ----------------------------------------------DDFDMVTSPRR--- ------------------------------------------------------------ ---LVKVNAKKP-------------EK-------------------------EEEDSEED FDMVTSPRRLVKVNIK-------------------------------------------- -----------------------KP----------------------------EE-EEEE ------------------------------------------------------------ ------------------------------------------------------------ ----EAG----------------------------------------------------- ------------------------------------------------------------ -D----SE-------------EDED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP--------------------------- L---GPGDPP-EPLLPSQP----VEIEIETPEV----RKK-------------QKAQAEF ETYLRRMMNRYKKDLLMDTHKVHLMCLIASGMFHNSLCSEQDLLAVTLSLLPAHFS---- --TISKERVDQNYLCGLLKW----------FRTTFTLNPSLPCEERP-----DPRALLER RLASLSARNHKELTH--------------------------------------------- ---------------------------------LFLLILRSLQLFCRLVLSLQPVPFKPP S--------------------------------------GK------------------- ------------------------------------------------GK---------- -----------------------------------------------------GAGRSTG VLEE-------------------------------------------------------- ------------------------------------------------------------ -----------------GHAS--------------------------------------- ------------------------------------------------------------ ---------------------------QET------------------------------ ---------------------------------SK------------------------- ------------------------------------------------------------ --TNSSEPKVS--------PG----------------TK--------------------R PA------------------------AGGDVKGGRG------------------------ -----------------------------GGGKKAKKKETK------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKPEEEAERATQTGGHRRKLQKRCSVSSKVCYKETDSEEDGEGEGIHD------- -----DEE------------------------------------------------YQ-- ----VTS---------EEDTE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------EAESEAKTTK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SNKGK----------GKS---------------- -----NNK-------KTASE---------------------------------------- ------------------------------------------------------------ ------------------------R----------------------------------- --------------------RRSGGGKKTVKD---------------------------- ------------------------------------------------------------ -------------------E-DRQW----------------------------------- -----EEEEEEGMSSNRTKRRSG------------------------------------- ----------------VKKE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVYLEKTSSWICVDVDH-G-VGMPHLCVQSATAPLTYV VSVDGDGSLKDLGRKYDPTWMTSTRKRRVDEDWWEETLQPFLGPEDEKDIKEDKEL-QNK LLSKPLPVSITEYKNHPLYALKRHLLKYEAIYPPTATVQGYCRGEPVYS--RSCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNNSRKARKTC-EQKDEKDLPLFGEWQTEEYQPPIA VDGK--------------------------VPCNDYGNVYLFKPCMLPVGCVHVRLPNLH RVARKLNIDTAAAVT-----GFDFHGGFSHPVTDGYIVCEEHEEVLRAAWLEEQEIQKQK EKEKREKRAISNWTLLVKGLIIRERLKQRY----------SKKNQTLES----------- ------------------------------LAREDDNSGLSSD-EE--PAEGGSG----- ------------EAKT--ASETLAMSWPQNRQ--------------------A--E-VDG ESGSKQKK----K----------------------------------------------- ------------------------------------------------------------ -------------------------------------------KRVQEKHLFPFEK-M >ENSGWIP00000021260 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRKE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------N RQPQTQTKKLKAKKKTTDRDNDDDAS---------------------------------- ------------------------------------------------------------ ----------------------------------EEEEKL-------------------- --------------------------------KRKV------------------------ ------------------KP----------------------------TPR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------LLSNRNARNTS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------TVTTSKYFQ--S------------- -----------------------------------------------PT----------- ---------------------------------------KEDE--D-----------SE- ----------------------------------------------DDFDMEMSPPP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------RGVSTSYK-------KQEE ------------------------------------------------------------ ------------------------------------------------------------ ----VED----------------------------------------------------- ------------------------------------------------------------ -D----SE-------------EDED-NWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP--------------------------- L---GPSEPS-DPALPYES----VEIEIETPEV----RKK-------------QKKKAEF ETYLRRMMMRFKKDLHTDTHKVHLMCLIASGMFRNKLCSEPDLLAVTLSLIPAHFS---- --SVSKERMDQHYLSGLLKW----------FRSTFTLNPSLPSEERP-----DPRALLER RLSSLSARDHQEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPIPLK-- ----------------QAATKVKSGRTLTKSR---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------QET------------------------------ ---------------------------------ST------------------------- ------------------------------------------------------------ --TNSPGTKVS--------PG----------------TK--------------------R PA------------------------GGGKVKAER------------------------- ------------------------------GGKRVRRKEIKEE-------------DEDE EDNKPAAKGRPK-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NL----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKISYKEESNS--- ----------------------------------------------------------EE E---------------------------------------------ECERLS-------- -----DEE------------------------------------------------FE-- ----AVS---------DVDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSE------------------------------------ --------------GGATSRAGRSKNKTSAAT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------K----------------------------------- --------------------RKSGGGKKTVK----------------------------- --------------------EEEEWKEVRVEEEEEEMTSSGTKIRRSG------------ ------------------------------------------------------------ ----------------------G------------------------------------- ----------------KKRE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GSDEWLEVYLQKSSSWVCVDVDH-G-VGMPHLCSQNATAPLTYV VSVDQEGFVKDLGRKYDPTWMTTSRKRRVDESWWEETLQPLLGPEDEKDVKEEKEL-QNK LLNKPLPISITEYKNHPLYALKRHLLKYEAIYPPTAAVLGYCRKEPVYS--RDCVHTLHS KDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMVS-EQKEEKDLPLFGDWQTEEYQPPIA VDGK--------------------------VPRNDYGNVYLFKPCMLPVGCVHLRLPNLH RVARKLDLDAAPAVT-----GFDFHGGYSHAVSDGYIVCEEHEEILRAAWVEDQENQKQK EREKKEKRATSNWTLLVKGLLIRERLKQRY----------SKKNQGLASTTG-------- GQN------------------------ADN--------GFSSD-EG--PAESGSC----- ------------GGKT--ASETLALSWPQNRQ--------------------K--E-EDN TGVSGLKK----KR---KTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGEEQHLFPFEK-V >ENSORLP00020032995 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRKKA-------------------------AET--------------- ------------------------------------------------------------ ---------------EKDT----------------KK----------------------- ------------------------------------------------------------ -----------------------------------------------------QRLVPK- -ADSCAAKTRTK---------------KKKAADDDIHE---------------------- ------------------------------------EEEL-------------------- --------------------------------QRKV------------------------ ------------------KP----------------------------KRR--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ------------------------------------------------------------ -----------------------------LKHAVQKVPASSPAPSP-------------- ------------------------------------------------------------ -----------------------------------DVKTSKYFK--T------------- -----------------------------------------------HL----------- ---------------------------------------GGEI--D-----------SE- ----------------------------------------------DDFDLVTSPPR--- -----IVKEA-------------------------------------------------- -------NHKKP-----------VKDKE-------------------------------- ------------------------------------------------------------ -----------------------------------------------------EE-EEEE ------------------------------------------------------------ ------------------------------------------------------------ ----E------------------------------------------------------- ------------------------------------------------------------ ------SD-------------SDDD-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPVEDS-EPFMPTQP----VEIEIETVEV----RKR-------------KKRQEEF ETYLRRMMKRYKKDLLIDTHKVHLLCLLANGIFRNSLCSEPDLLAVTLSLIPPHFC---- --TVDKKCIDQNYLCALLKW----------FRATFTLAPLLPQEENP-----EPRILLER RLATFSARDHQEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPVPFKPP S--------------------------------------AK------------------- ------------------------------------------------SK---------- -----------------------------------------------------GVRTSTT TSEK-------------------------------------------------------- ------------------------------------------------------------ -----------------GQTS--------------------------------------- ------------------------------------------------------------ ---------------------------QET------------------------------ ---------------------------------SE------------------------- ------------------------------------------------------------ --TNSPEQNVS--------PG----------------SK--------------------R PA------------------------KEKKLKESG------------------------- ------------------------------GGKRTKIKEMK-----------------HE EE-KPVLSGGRR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVNYKEGSNS--- ----------------------------------------------------------EG D---------------------------------------------DEDDLSD------- -----EED------------------------------------------------FQ-- ----ATS---------EEDSD-FE------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R EVKPRKGKIGKGGAAKKKTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------AP---------------------------------------- ------------------------------------------------------------ ------------------------K----------------------------------- --------------------KKKKGGQKQVK----------------------------- ------------------------------------------------------------ -----------------DEK-DSDWE---------------------------------- EEEQ--------------------------------------EEAERVEGKGKRRSVRRG ------------------------------------------------------------ ---------------------------------G-------------------------- -------------------------------------------------A---------- ------------------------------------------------------------ ----------------GADEWLEVFLEKSSSWVCVDVEH-G-VGMPHLCSQNATEPVTYV VAVDGNRFLKDLGKKYDPTWMTASRKRRVDDDWWEETLQPFLGPEDERDVKEEKEL-QSK LLNKPLPVSVAEYKNHPLYALKRHLLKYEALYPATATVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMAS-EQKDHKDLGLFGDWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFKPCMLPVGCVHLRLPNLH RVAKKLNLDAAAAVT-----GFDYHGGYSHAVTDGYIVCEEDEEILRAAWVEDQEIQKKK EKEKKEKRAVANWTLLVKGLLIRERLRQRY----------SQKNQGVGS----------- ------------------------------AAREDNADCFSSD-EE--PAGGDGT----- ------------GAKT--ASEALAMSWPQNRQ--------------------T--E-EGG GGAGTLKK---------TTRRG-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKGQEQHLFPFEK-V >ENSORLP00000041298 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRKKA-------------------------AET--------------- ------------------------------------------------------------ ---------------EKDT----------------KK----------------------- ------------------------------------------------------------ -----------------------------------------------------QRLVSK- -ADSSAPKTRTK---------------KKKAADDDIHE---------------------- ------------------------------------EEEL-------------------- --------------------------------QRKV------------------------ ------------------KP----------------------------KRR--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ------------------------------------------------------------ -----------------------------LKHAVQKVPASSPAPSP-------------- ------------------------------------------------------------ -----------------------------------DVKTSKYFK--T------------- -----------------------------------------------HL----------- ---------------------------------------GGEI--D-----------SE- ----------------------------------------------DDFDLVTSPPR--- -----IVKEA-------------------------------------------------- -------NHKKP-----------VKDKE-------------------------------- ------------------------------------------------------------ -----------------------------------------------------EE-EEEE ------------------------------------------------------------ ------------------------------------------------------------ ----EES----------------------------------------------------- ------------------------------------------------------------ -D----SE-------------DDDD-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPVEDS-EPFLPTQP----VEIEIETVEV----RKR-------------KKRQEEF QTYLRRMMKRYKKDLLIDTHKVHLLCLLANGIFRNSLCSEPDLLAVTLSLIPPHFC---- --TVDKKCIDQNYLCALLKW----------FRATFTLDPLLPLEEHP-----EPRILLER RLATFSARDHQEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPVPFKPP S--------------------------------------AK------------------- ------------------------------------------------SK---------- -----------------------------------------------------GVRTSTT TSEK-------------------------------------------------------- ------------------------------------------------------------ -----------------GQTS--------------------------------------- ------------------------------------------------------------ ---------------------------QET------------------------------ ---------------------------------SE------------------------- ------------------------------------------------------------ --TNSPEQNVS--------PG----------------SK--------------------R PA------------------------KEKKLKERG------------------------- ------------------------------GGKRTKIKEMK-----------------HE EE-MPVLSGGRR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVNYKEGSNS--- ----------------------------------------------------------EG D---------------------------------------------EEDDLGD------- -----EED------------------------------------------------FQ-- ----ATS---------EEDSD-FE------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R EVKPRKGKIGKGGAAKKKTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------AP---------------------------------------- ------------------------------------------------------------ ------------------------K----------------------------------- --------------------KKKNGGQKQVK----------------------------- ------------------------------------------------------------ -----------------DEK-DSHWE---------------------------------- EEEQ--------------------------------------EEAERVEGKGKRRSVRQG ------------------------------------------------------------ ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVFLEKSSSWVCVDVEH-G-VGMPHLCSQNATEPVTYV VAVDGNRFLKDLGKKYDPTWMTASRKRRVDDDWWEETLQPFLGPEDERDVKEEKEL-QSK LLNKPLPVSVAEYKNHPLYALKRHLLKYEALYPATATVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMAS-EQKDHKDLGLFGDWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFKPCMLPVGCVHLRLPNLH RVAKKLNLDAAAAVT-----GFDYHGGYSHAVTDGYIVCEEDEEILRAAWVEDQEIQKKK EKEKKEKRAVANWTLLVKGLLIRERLRQRY----------SQKNQGVGS----------- ------------------------------AAREDN------------------TGGL-- -SSDEE---QAGGAKT--ASEALAMSWPQNRQ--------------------T--E-EGG GGAGTLKK---------TTRRG-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKGQEQNLFPFEK-V >ENSORLP00015029518 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRKKA-------------------------AET--------------- ------------------------------------------------------------ ---------------EKDT----------------KK----------------------- ------------------------------------------------------------ -----------------------------------------------------QRLVPKE AESSSAAKTRTK---------------KKKAADDDIHE---------------------- ------------------------------------EEEL-------------------- --------------------------------QRKV------------------------ ------------------KP----------------------------KPR--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ------------------------------------------------------------ -----------------------------AKHAVQKVPASSPAPSP-------------- ------------------------------------------------------------ -----------------------------------DVKTSKYFK--T------------- -----------------------------------------------HL----------- ---------------------------------------GGEI--D-----------SE- ----------------------------------------------DDFDLVTSPPR--- -----IVKEA-------------------------------------------------- -------NHKKP-----------VKDK--------------------------------- ------------------------------------------------------------ --------------------------------------------------------EEEE ------------------------------------------------------------ ------------------------------------------------------------ ----EES----------------------------------------------------- ------------------------------------------------------------ -D----SE-------------DDDD-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPVEDS-EPFLPTQP----VEIEIETVEV----RKR-------------KKRQEEF ETYLRRMMKRYKKDLLIDTHKVHLLCLLANGIFRNSLCSEPDLLAVTLSLIPPHFC---- --TVDKKCIDQNYLCALLKW----------FRATFTLDPLLPLEEHP-----EPRILLER RLATFSARDHQEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPVPFKPP S--------------------------------------AK------------------- ------------------------------------------------SK---------- -----------------------------------------------------GVRTSTT TSEK-------------------------------------------------------- ------------------------------------------------------------ -----------------GQTS--------------------------------------- ------------------------------------------------------------ ---------------------------QET------------------------------ ---------------------------------SE------------------------- ------------------------------------------------------------ --TNSPEQNVS--------PG----------------SK--------------------R PA------------------------KETKLKESG------------------------- ------------------------------GGKRTKIKEVK-----------------HE EE-KPVLSGGWR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVNYKEGSNS--- ----------------------------------------------------------EG D---------------------------------------------DEDDHSD------- -----EED------------------------------------------------FQ-- ----ATS---------EEDSD-FE------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R EVKPRKGKIGKGGAAKKKTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------AP---------------------------------------- ------------------------------------------------------------ ------------------------K----------------------------------- --------------------KKKKGGQTQVK----------------------------- ------------------------------------------------------------ -----------------DEK-DSDWE---------------------------------- EEEQ--------------------------------------EDAERVEGKGKRR--RQG ------------------------------------------------------------ ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVFLEKSSSWVCVDVEH-G-VGMPHLCSQNATEPVTYV VAVDGNRFLKDLGKKYDPTWMTASRKRRVDDDWWEETLQPFLGPEDERDVKEEKEL-QSK LLNKPLPVSVAEYKNHPLYALKRHLLKYEALYPATATVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMAS-EQKDHKDLGLFGEWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFKPCMLPVGCVHLRLPNLH RVAKKLNLDAAAAVT-----GFDYHGGYSHAVTDGYIVCEEDEEILRAAWVEDQEIQKKK EKEKKEKRAVANWTLLVKGLLIREKLRQRY----------SQKNQGVGS----------- ------------------------------AAREDNAGGFSSD-EE--PAGGDGT----- ------------GAKT--ASEALAMSWPQNRQ--------------------T--K-EGG GGAGTLKK---------TTRRG-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKGQEQHLFPFEK-V >ENSOMEP00000006773 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRKKA-------------------------SET--------------- ------------------------------------------------------------ ---------------DVDT----------------K------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------KPRLPRAKRSAAKTRPKKKAADDDIIT---------------------- ------------------------------------DEEL-------------------- --------------------------------QRKV------------------------ ------------------KP----------------------------KPR--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------PS------ ------------------------------------------------KRA--------- -------MQTVSASSPTAGPDVQTMEAKC------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------KKP-----------VKDK--------------------------------- ------------------------------------------------------------ --------------------------------------------------------EEEE ------------------------------------------------------------ ------------------------------------------------------------ ----EES----------------------------------------------------- ------------------------------------------------------------ -D----SE-------------D-DD-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GPAEAS-EPSLPSEP----VEIEIETAEV----RKR-------------KKRQEEF ETYLRRMMKRYKKDLLIDTHKVHLLCLLANGIFRNRLCGEPDLLAVTLSLLPAHFC---- --SVDKKCIDQNYLCALLKW----------FRATFTLNPLLPQEEDPSDLPA----LLER RLATFTARDHQEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPVPFKPP S--------------------------------------AK------------------- ------------------------------------------------SK---------- -----------------------------------------------------GVRTSTS ------------------------------------------------------------ ------------------------------------------------------------ ------------------QTS--------------------------------------- ------------------------------------------------------------ ---------------------------RET------------------------------ ---------------------------------SE------------------------- ------------------------------------------------------------ --TNSPEQKVS--------PG----------------SK--------------------R PQ------------------------KEKKLKQSG------------------------- ------------------------------GGKKAKTKEIK-----------------HE EE-KLVLSGGRR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RRVASKVSYKEESNS--- ----------------------------------------------------------EG D---------------------------------------------EEEE--D------- -----GED------------------------------------------------FQ-- ----ATSE-------EEEDSD-FE------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S EVKPRKGKMGKG------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------KAT--------------------------------- ------VTASKKNVG----PKKKNDGKKHVK----------------------------- ------------------------------------------------------------ -----------------DEE-DSDWE---------------------------------- EEKQ--------------------------------------EDDERVEGTGKRRSVRRG ------------------------------------------------------------ ---------------------------------G-------------------------- -------------------------------------------------P---------- ------------------------------------------------------------ ----------------GADEWLEVFLEKSSSWVCVDVEH-G-VGMPQLCSQNATEPVTYV VAVDGNGFLKDLGRKYDPTWMTTSRKRRVDDDWWEETLQFFLGPEDERDVKEEKEL-QSK LLNKPLPISVAEYKNHPLYALKRHLLKYEALYPATATVLGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARMAS-EQKDHKDLGLFGEWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFKPCMLPVGCVHLRLPNLH RVAKKLNLDAAAAVT-----GFDYHGGYSHAVTDGYIVCEEDEEILRAAWVEEQEIQKKK EKEKKEKRAVANWTLLVKGLLIRERLRQRY----------SQKNQGVGS----------- ------------------------------VAREDDAGGFSSD-DEAAAAGGDGD----- ------------GAKT--ASETLAMSWPQNRQ--------------------T--Q-EGG GGAGTLKK---------TTKRG-------------------------------------- ------------------------------------------------------------ -------------------------------------------RKGQEQHLFPFEK-V >ENSCSEP00000009461 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---MK------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----EETMA-------------------------------------------------- ------------KRKDC-------------------------AEK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------QVVPKKAKHLLKTKNSASKA AKK--------------------------------------------------------- ------------------------REAENVVTVKKEEEEEKLVRRIQTKSQSVTSKPTAG SNTLKSTSAT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------TVNTSQYFQ--S------------- -----------------------------------------------AV----------- --------------------------------------KDEED--D-----------SE- ----------------------------------------------DDFDMVTSPAS--- ---------------KLAAR--------------------TKRVE--------------- ------------------------KDK-----------------------EEEDDDS--- ------------------------------------------------------------ -----------------------------------------------------------D ------------------------------------------------------------ ------------------------------------------------------------ ----EDD----------------------------------------------------- ------------------------------------------------------------ -D----SD-------------EEED-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------DEP--------------------------- L---GPVEAA-EPDLPTQA----VEIEIETVEV----KKK-------------KKRQAEY ETYMRRMINRYKKDLLMDTHKVHLMCLIGSGMFRNRLCSEPDLLAISLSLLPAHFG---- --KVAKERIDQNYLSGLLKW----------FRATFTLNPSLPYEERP-----DPQALLER RLASLSARNHQEMTH--------------------------------------------- ---------------------------------LFLLFLRSLLLSCRLVLSLQPVSFKPP S--------------------------------------AK------------------- ------------------------------------------------AK---------- -----------------------------------------------------GGGKSAG DSGK-------------------------------------------------------- SPKN-------------------------------------------------------- --KET--SRTTT------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EQKVS--------PG----------------TK--------------------R AA---------------------------KSKGDH------------------------- ------------------------------GGKKAKREDTK-----------------EK EE-KTVKPGGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESNS--- ----------------------------------------------------------EA E---------------------------------------------E--RLSD------- -----EEE------------------------------------------------FQ-- ----VTS---------EEDSD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DFESEAKSSK----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------NGKAKSKVKNNRKTAATEKNVKEKL VKEKEEEEGNEGGEAS-------------------------------------------- ------------------------------------------------------------ ------------------KRRSG------------------------------------- -----------------KKT---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------S---------- ------------------------------------------------------------ ----------------GADEWLEVYLDKTASWVCVDVEH-G-VGVPKLCSQNATAPVTYV VSVDGDGFLKDLGKKYDPTWMTSSRKRRVDDEWWEETLAPFLGPEDERDKKEEKEL-QNR LLNKPLPISIAEYKNHPLYALKRHLLKYEAIYPSTATVLGYCRGEPVYS--RDCVQTLHS RDTWLKEARTVRLGEEPYKMVKGFSNRSRKARIMS-DTKNENDLALFGEWQTEEYQPPIA VDGK--------------------------VPRNEYGNVYLFKPCMLPVGCVHLRLPNLH RVARKLDLEAAPAVT-----GFDFHGGYSHAVTDGYIVCEEHEEILRAAWSEDQEFQKQK EKEKKEKRAFSNWKLLVKGLLIRERLKKRY----------SKKNLGL------------- --VHHG------------------DNDV----------GLSSD-EE-------------- -----EVDSKSSPTKT--ASETLAMSWPQNRQ--------------------T--E-VGS GNSSGQKK----NS---TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQERHLFPFEK-A >ENSHHUP00000062691 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRKES-------------------------ADTAV------------- ------------------------------------------------------------ ---------------KTNT----------------KK----------------------- ------------------PKVAKG----KAGGLRAKKENG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EETEKV-------------------- --------------------------------QRKA------------------------ ------------------KH----------------------------KSR--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------LSKPIVG DTTETN------------------------------------------------------ --------------------------------------TSKYFQDKT------------- -----------------------------------------------P------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------G--------KEEPADMS----------PE---------------- --------SDIIPSFIRARKDTVKPV-------------------------------KKE ------------------------------------------------------------ ------------------------------------------------------------ ----EED----------------------------------------------------- ------------------------------------------------------------ -E----DS-------------EEDE-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SEP--------------------------- L---GPVEPV-EPALPSQP----VEIEIETPEIIHKRQKR-------------EKRKAEF ETYLRRMMNRFNKDVVEGTHKVHLMCLLANGMFRNRLCSTPDLLAISLSLLPTHFA---- --MVAKERIDTNYLSGLLKW----------FGATFTLNPELPYEERP-----DPQALLER RLGSLTARDHQEMTH--------------------------------------------- ---------------------------------LFLLMLRSLQLFCRLVLSLQPLSLKPP S--------------------------------------AK------------------- ------------------------------------------------SK---------- ------------------------------------------------------------ ------------------------------------------------------------ -AKNSGSPPRKS--------P-----------------------------------AQKK PPKE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---SPSKPKVS--------PG----------------SK--------------------R PA------------------------GG---KAER------------------------- ------------------------------GGKKAKKKE-----AGEM------------ ---EKVVSVGQK-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSIASKVSYKEESS---- ------------------------------------------------------------ ----------------------------------------------EGEGPSD------- -----GEE------------------------------------------------FQ-- ----LTN---------EEDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSEGGAKAIRTK--------------------K------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GNGGK----------GKS---------------- -----------------TAP---------------------------------------- ------------------------------------------------------------ ------------------------Q----------------------------------- --------------------KRSSGGKKKVK----------------------------- ------------------------------------------------------------ ----------------SEEE-DDDWEG--------------------------------- -KEEEGEEEEQGM-------KRG------------------------------------- ----------------KRKE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------T---------- ------------------------------------------------------------ ----------------GADEWLEVYLEKTGCWVCVEVLQ-G-VGQPHLCSKQATHPMTYV VAVDGDGHLKDLGSKYDPTWMTSTRKRRVDEEWWELTLEPFLGPESERDVQEDKEL-QAK LLDKPLPTSIAEFKNHPLYALKRHLLKYEALYPSTAAILGYCRGEPAYS--RDCIHTLHS RDTWLKEARTVRLGEEPYKMVRGFSNRSRKVRMAS-EQKDKDDLPLFGEWQTEEYQPPVA VDGR--------------------------VPRNDFGNVYLFKPCMQPVGCVHLRLPNLQ RVAKKLDMDCAAAVT-----GFDFHGGYSHAVTDGYIVCEEHEEILRAAWVEDQEIQRQK EKEKREKRAVTNWTLLVKSLLIRERLQRRY----------GKK----------------- -----GPTPGGGLDQLKSQDREGVE-------------GLSSE-EE----------GE-- -G----------GPNT--ASAALAQAWPQNRQ--------------------E--E-QDS GTG-----GA-YKT---TSKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGQQKHLFPFEK-V >ENSELUP00000011005 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KSKKS-------------------------ADTAV------------- ------------------------------------------------------------ ---------------KTDT----------------KKLKQV------------------- ----KGKTRGSARAKKDQ-------------------ENG-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EETEKI-------------------- --------------------------------QRKA------------------------ ------------------KT----------------------------KSR--------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PYK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------PIAERTKS------- ------------------------------------------------------------ ---------------------------------------SKYFQDNT------------- -----------------------------------------------PVKGVPADVIPAF IST-----------------------RND--TVMFPKNKEDDD--D-----------SE- ----------------------------------------------ED------------ ------------------------------------------------------------ ------------------------------------------------------DDS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----EED----------------------------------------------------- ------------------------------------------------------------ -D----DS-------------EEDD-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GSVEPL-EPALPSQP----VEIEIETPDILLKRQRR-------------EKRKTEF ETYLRRMMNRFNKDVVEDTHKVHLMCLLANGMFRNQLCSTPDLLAITLSLLPTHFN---- --MVAKERIDANYLSGLLKW----------FETTFTLNPNLSCEEKL-----DPQALLES RLGSLTARDHQEMTH-------------------------------EGQRLDTGQGFRAL VGILWTKQVVR-W------------------VKLFLLVLRSLQLFCRLVLSLQPLSLKAP S--------------------------------------AK------------------- ------------------------------------------------SK---------- ------------------------------------------------------------ ------------------------------------------------------------ -AKTSGSLPGKS--------P-----------------------------------SQKK PAKE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---NRSEHKVS--------PG----------------TK--------------------R PAAGTG----QRGAKKSKIKEADPELG--------------------------------- ------------------------------------------------------------ ------VSSGQK-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NS----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSVASKVSYKEESS---- ------------------------------------------------------------ ----------------------------------------------EGEGPSD------- -----GDE------------------------------------------------FQ-- ----PTT---------EENSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSEGAAKPIRCE--------------------K------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GKGGKSQAKMSDPRRG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GGKKKVK----------------------------- ------------------------------------------------------------ ----------------SEEEGDEDWEGGEEGEAEEVKGGRRK-----------------G EK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GADEWLEVYLEKTGCWVCVDVMQ-G-VGQPQLCARQATHPMTYV VAVDGDGHLKDLGSKYDPTWMTATRKRRVDEEWWEETLGPFLSPESERDIQEDKEL-QAR LLDKPLPTSIAEFKNHPLYALKRHLLKYEALYPPTAATLGYCRGEPVYS--RDCIHTLHS RDAWLKEARTVRLGEEPYKMVRGFSNRSRKARIAS-EQKEKDDLPLFGEWQTEEYQPPVA VDGR--------------------------VPRNDFGNVYLFKPCMLPLGCVHLRLPNLH RVAKKLGMDCALAVT-----GFDFHSGYSHAVTDGYIVCEEHEEILRAAWVEDQEIQKQK EKEKREKRALSNWTLLVKGLLIRERLHRRY----------GKK----------------- -----GPTAGGGLEELKRQNREGED-------------GLSSE-EE----------GE-- -G----------GPNT--AAATLAQAWPQNRQ--------------------E--V-QDS GTGAPPKK----------SKQE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGQQKHLFPFEK-- >ENSCHAP00000002403 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------S-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------V---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------D-----------AE- ----------------------------------------------DD------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------DFTTPTVSVASGAK------KTETKKE-DEDD ------------------------------------------------------------ ------------------------------------------------------------ ----ECE----------------------------------------------------- ------------------------------------------------------------ -D----DS-------------DEDG-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TGP--------------------------- L---GPAAPA-EPTIPSQP----VEIEIETPEVARKRQQK-------------EKRKTEF ESYLRRMMKRFNKDLVEDTHKVHVLCLLANGIFRNHVCREPDLIAITLSLMPSHFT---- --ALIR-RVDTIFLNDLLKW----------FGDTFTLNPELPEETGQ-----GLMAVLER RLGSLTVRNHEEMTH--------------------------------------------- ---------------------------------LFLLVLRSLQLFCRLVLSLQPLPIKPP P--------------------------------------AK------------------- ------------------------------------------------DK---------- ------------------------------------------------------------ ------------------------------------------------------------ -PKTSKSPADKSQS------P-----------------------------------GKKR PTEKSAAEK--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TSPEAKVS--------PG----------------SK--------------------R PAT-----------------------GRGEGKTER------------------------- ------------------------------GGKRPKKK---------HGTGEMEG----- --------TGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NT----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T R-----------------------------------------RSVASKVSYKDESSE--- ----------------------------------------------------------EE AD-------------------------R-----------------------SS------- -----EEE------------------------------------------------FQ-- ----LSSGGE----SEEEEEE--------------------------------------- ------------------------------------------------------------ --------------------------GGKK------------------------------ -----------------------------------------------------K------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GRAGK----------GKGVAK------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------GKSRAPRRSSGAKKTKK----------------------------- ------------------------------------------------------------ -------------EIKSEEE-------------DE------------------------- EGEE---------------------------------------------ETGK------- ----------------KRRE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------K---------- ------------------------------------------------------------ ----------------GNDEWLEVYLEEAGRWVCVDVEQ-G-VGQVQKCAAHATRPLVYV VGVDGEGYIKDLSRRYDPTWLTSSRKRRIDQDWWDETLDIYEAPDSEREKKEDNEVAQAK LLSKALPTSILEYKSHPLYALQRHQLKYEALYPPTAAILGYCRGEPVYS--RDCIHTLHS KDTWLKEARTVRLGEVPYKMVRGFSNQSRKARMMS-EHKVEKDLPLFGEWQTEEYQPPVA VDGK--------------------------VPRNDFGNVYMFKPCMMPIGCVSLRLPNLH RVARKLDIDCALAVT-----GFDFHGGYSHAVTDGYIVCEEHEEILRAAWENEQEIQQKK EIEKREKRVVSNWTLLVKGLLIRERLKRRY----------GQQ--------GLTQQPAGI GQGEQG----------------GVD-------------GLSSG-EE----------AEEV GG----------GPST--DAPSLASSWPQNRQ--------------------E--E-EET PKQSG-------------SKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGQKKHLFPFEK-V >ENSDCDP00000055594 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---I-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------P-------QKAMSKT------ ---------A-------------------------------------------------- ------------RR---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------T--------------------------- -----------------------------------SVRTSKYFG---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KQSRNKEG----------- ------------------------------------------PEVIG------------- -----------------------------------------------------DEGDQDE N---------------------------------SNLIIPHIESKI-------------- ----------------------------------------------------------KT ----EED----------------------------------------------------- ------------------------------------------------------------ -E----AS-------------EEDE-DWEEVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AEP--------------------------- L---GP---P-EMSRPSQL----LEIEIETPEMASQRQKR-------------EKSQNEF ESYLRRMMKRINKDMLEEMHKVHLLCLLAGGMIQNRLFLNPDLLAVALSLVPTRFTTSPP RAM----------------WPFFKMYMIFRFTVTFTLNSALPEEKEV-----EPRAVLEK RLGSLSIRDHQEMTH--------------------------------------------- ---------------------------------LFLLVLRSLRLFCRLVLSLQPVPFKPP T--------------------------------------AK------------------- ------------------------------------------------TK---------- ------------------------------------------------------------ ------------------------------------------------------------ -AKT----------------------------------------------DQTKNSS--- ------AEK--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TKDEPKVS--------LG----------------SK--------------------R PSGRCSGAKAER------------------------------------------------ ------------------------------GGKRQKK---------DRAL--TQG----- --------TGQR-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NT----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------K R-----------------------------------------RSIASKVNYKEVSSGA-- ----------------------------------------------------------EG ES-------------------------------------------------SE------- -----GEE------------------------------------------------FQ-- ----INS---------EAESD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSD------------------------------------ -------------------------------------------------FDMGT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKGK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------M---------SQASRKPGGVKKQVS----------------------------- ------------------------------------------------------------ -----------------SEE---------------------------------------- EEEE-------------------------KEEKPL------------------RRV---- ----------------KRKE---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------K---------- ------------------------------------------------------------ ----------------GEDEWLEVYLDGEDKWVCVDVVQ-G-VGQEMLCSSQATQPLSYI IAIDGDGCVKDLSSRYDLTWMTSSRKRRVDQEWWEETLGFYKPLVSERERSEDREL-QAR LLNKPLPTSIAEYKNHPLYALARHLLKYEALYPHTAAIIGYCKGEAVYS--RDCVHTLHS RDTWLKEARTVRLGEEPYKMVRGFSNQSRKARMMS-ELKDKKDLPLFGEWQTEEYEPPIA LDGK--------------------------VPRNDFGNVYMFKPCMLPVGCVHLHLPNLH RVARKLNMDCAPAVT-----GFDFHGGYSHAVTDGYIVCEDHKEILTAAWENEQELLKIK EREKREKRVLSNWTLLVKGLLIRERLKRRY----------GQQ----------------- -----GLTQQPRVGQGKEV---GPD-------------GLSSG-EE----------EE-- -G----------GTSM--DTTTLVTSWPQNRQ--------------------E--E-QDD AT-----K----KA---TTKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------RRGQEKHMFPFEK-V >ENSSFOP00015023937 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRK--------------------------------------------- ----------------GS------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AARA AKAHDHDKKKCKEVEEGKKKGQKEGANIVQKAETRYAAKTAKNFKKEKCPSQGSRSKCK- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------T-------------------------------- ----------------------------------------------------PG------ ------------------------------------------------KR---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------TSKYFH---------------- ------------------------------------------------------------ ---------------------------N-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------SSEVKDEPVVTSDDGDDDGNNSTGVAQPESAPSVLKVAK- ----EEE----------------------------------------------------- ------------------------------------------------------------ -E----ES-------------DEDV-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------TE---------------------------- ---------T-TAVLPSQP----VEIEIEAPEHSLKRQRR-------------EKRKAEF ETYLRRMVKRFNKELLVDMHKVHLLCLVANGIFRNRLCSDPDLLAIALSLLPARFT---- --TTPPEDVDTSFLCSLLKW----------FGATFTMNPELPEKPQE-----SARDVLEK RFGSHCARDHQEMTH--------------------------------------------- ---------------------------------LFLIMLRSIRLFCRLVLSLQPVPLKAA P--------------------------------------DK------------------- ------------------------------------------------NK---------- ------------------------------------------------------------ ------------------------------------------------------------ -TKAAG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -NAPSQGSAKACVSPGEKRSARSRSSGPERGGKRQRKREKEQKEE-----------TEEE KE-GVETAAVLK-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NK----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q R-----------------------------------------RSVASKVCYKEESS---- ----------------------------------------------------------EG E------------------------------------------------EVSD------- -----GEE------------------------------------------------FR-- ----ASS---------AEDSE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSEAEV--------------------------------- -----------------NRRP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------GRKGR----------GRGEAS------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RNQ------DNRKDENSEEE---------------------VIKS--------------- ------------------------------------------------------------ ---------------FKRKR---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------K---------- ------------------------------------------------------------ ----------------GEDEWLEVYLEQAERWVCLDVQQTG-VGQPMLCSRQATQPLSYV LAVDGDGCLKDLGCKYDPTWLTSTRKRRVDQEWWEESLQSFRSPASPREEKEDKEL-QAK LLDKPLPTSIAEYKNHPLYALKRHLLKYEALYPPTAAILGYCRGEAVYS--RDCIHTLHS RDTWLKEARTVRLGEVPYKMVKGFSNRSRKARLEP-QNRDIDDLALFGHWQTEEFQPPVA VDGK--------------------------VPRNEFGNVYLFRACMLPVGCVHMRLPNLH RVARKLDIDCAAAVT-----GFDFHGGFSHPVTDGYIVCEEYQEVLQAAWENEQELIEKK EREKREKRVLANWALLAKGLLIKERLRKRY----------GAKG--------VEQMP--- ----------------------GQE-------------GLSSG-EE----------EE-- -G----------ERQT--AAVDLATYWPQNRQ--------------------E--D-QGA EASG---Q----KP---ITKRE-------------------------------------- ------------------------------------------------------------ -------------------------------------------KKGQEKHLFPFEK-V >ENSPKIP00000034363 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------A-------------------------------------------------- ------------KRK--------------------------------------------- ----------------GSIGAVS------------------------------------- ---------------KVDT----------------KKLKESANAKTKG------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------T---- --------------------------------------------------------KCKK EADTEVARLISAEKTTKKTKIQKSR----------------------------------- ------------------------------------------------------------ -----------------------PKKNT-------------------------------- ----------------------------------------------------PG------ ------------------------------------------------QR---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------TSKYFQ---------------- ------------------------------------------------------------ ---------------------------NDFITI--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SD-------------------------------------------DE-DEDD -------------------------------------------------------DEDGD AAPHSDNEAAELKVENKVEGSDE------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DEDE-EWEDVE---------------------------- ---------------------------------------------------EL------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------AD---------------------------- ---------T-SCVVPSQP----VEIEIEAPEHVAKRLKR-------------EKRKVEF ETYLRRMVNRFNKELFVDMHKVHLLCLVANGMFRSRLCSDPDLLAVALSLLPAHFT---- --TTPPEEVTTPFLCGLLKW----------FQATFTLTLELPEEPER-----NPREILER RLGSLSARDHQEMTH--------------------------------------------- ---------------------------------LFLIVLRSLRLFCRLVVSLQPIPLKEP P--------------------------------------AK------------------- ------------------------------------------------NK---------- ------------------------------------------------------------ ------------------------------------------------------------ -AKSPGGTPQKS--------PK-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EPKAS--------PG----------------TK--------------------R SA------------------------GGRASGAGRNVKRQRKKVEEEEEEEDGEEQEAEA VTTPTQ------------------------------------------------------ -----------R-------------------------------------------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------------------------------------------------NK----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------Q R-----------------------------------------RSIASKVYYKEESS---- ----------------------------------------------------------EG E------------------------------------------------EHSE------- -----EEE------------------------------------------------FL-- ----VS-----------EEEE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DSEGEA--------------------------------- -----------------TRRP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DKKGK----------G------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------KSRSEASQRQGSRNKGG DEEE-------------------------------------------------------- -----------VLMEFKRKQ---------------------------------------- ---------------------------------G-------------------------- -------------------------------------------------K---------- ------------------------------------------------------------ ----------------GEDEWLEVHLQQAGEWVCLDVQQGN-VGKPLLCSKRATQPLTYV LAVDGDGCLKDLGCRYDPTCMTASRKRRVDQEWWEETLDSFRSRASKREQREDQEL-QAK LLDKPLPTSITEYKNHPLYALQRHLLKYEAIYPSTAAILGYCRGEPVYS--RDCVHTLHS RDTWLKEARTVRLGEVPYKMVKGFSNRSRKARLVP-ENRDIDDLPLFGPWQTEEYQPPVA VDGK--------------------------VPRNDYGNVYMFRPCMLPVGCVHLRLPNLH RVARKLEIDCAAAVT-----GFDFHGGFSHPVNDGYIVCEEHKEVLLAAWENEQEILEKK EREKREKRVLANWTLLVKGLLIRERLKRRY----------GAKN--------KEQAA--- ----------------------GPE-------------GLSSD-EE----------EG-- -D----------GSQT--TAVDLATSWPQNRQ--------------------E--E-PEG ATSG---R----KA---ASKRD-------------------------------------- ------------------------------------------------------------ -------------------------------------------KRGQEKHLFPFEK-L