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SxVPSTSSRQYTRQRITRVNLRDLIFYMEQERETAHSLLLYRALLK >ENSLCAP00010033840 -------------------------------------------------- -------MAGASDPLEDMLF--SEVDEKAVSDLVGSLESQLTGQSNPAxx xxxxxxxxxxxxxxxxxxxxLxxx--xxxxxxx----------------- -------------------------------------------------- ------------------------------------x------------- ----QQQ------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxx-xxxxxxxxxxxxxxPSLxCTxS FGEPPTTSxxxxxxxxxxx------------------------------- ----------------------------------------------QSHG AS-xxxx---------------------------xxxxxxxxx------- -------------------------------------------------- -----------------------x-xxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxxxxxxEx xxxxxxxxxxxxxxxxxxxxxxxxLNGxxxxxxxxx-------------- -------------------------------------------------- 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AVxxx--------------------------------xxxPVVM------ -----------------------------------------xxxx-PAQS ASQPV--------------------------------------------- ----xxxxxxxxxxxxx---PVVSQEMQENVKKCKNFLATLIKLASHNSP SPETSKNVKALVQDLLDAKIEPEEFTSRLQTELKSSPQPYLVPFLKKSLP ALRLSLLNSQQSLTx----------------------x------------ ---------------xxQxxx----------------------------- ---xA-Px----------------------------------------xx xxxxxxGPAVRIHHP---------------------------------NS VSTxxxxxxxxxGTxxx--------------xAAx--------------- -------------------------------------------------- -------------------G--------------------VKTG-GAVGG QVRMPVVITQSIRAQ----------------------------------- -----------GTM-G--------KGAIIQAGKSPMGLPVQISGNQKNKL NDPGGGSFRDDDDINDVASMAGVNLNEESARILATNSELVGTQIRSCKDE AFLHPGLLHRRILETAKKFGVTEVPMEAVTFISHATQSRLRTVVEKVSTI AQHRLDSCKDDEC--YEQSADVRSQLRFFEQLERIEKQRKDEQEREILLK AAK---------------SRSRQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKMDSPGATPS-GTEV-------------------x GxxAG----SPA-------------------------------------- -------------------------------------------------S SxAPSTSSRQYTRQRITRVNLRDLIFYMEQERETAHSLLLYRALLK >ENSAPEP00000015405 -------------------------------------------------- -------MAGASDPLEDMLF--SEVDEKAVSDLVGSLESQLAGQSNPVxx xxxxxxxxxxxxxxxxxxxxLxxx--xxxxxxx----------------- -------------------------------------------------- ------------------------------------x------------- ----QQQ------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxx-xxxxxxxxxxxxxxPPLxCTxS FGEPSATSxxxxxxxxxxx------------------------------- ----------------------------------------------QSHG AS-xxxx---------------------------xxxxxxxxx------- -------------------------------------------------- -----------------------x-xxxxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxEx 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-----------------xxxxxx-------------------------xx Axxxx--------------------------------xxxPVVM------ -----------------------------------------xxxx-PAQS ASQPV--------------------------------------------- ----xxxxxxxxxxxxx---PVVSQEMQENVKKCKNFLATLIKLASHNSP SPETSKNVKALVQDLLDAKIEPEEFTSRLQTELKSSPQPYLVPFLKKSLP ALRLSLLNSQQSLTx----------------------x------------ ---------------xxQxxx----------------------------- ---xA-Px----------------------------------------xx xxxxxxGPAVRIRHP---------------------------------NS VSTxxxxxxxxxGTxxx--------------xAAx--------------- -------------------------------------------------- -------------------G--------------------VKTG-GAVGG QVRMPVVITQSIRAQ----------------------------------- -----------GTM-G--------KGAIIQAGKSPMGLPVQISGNQKNKL NDPGGGSFRDDDDINDVASMAGVNLNEESARILATNSELVGTQIRSCKDE AFLHPGLLHRRILETAKKFGVTEVPMEAVTFISHATQSRLRTVVEKVSTI AQHRLDSCKDDEF--YEQSADVRSQLRFFEQLERIEKQRKDEQEREILLK AAK---------------SRSRQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKMDSPGATPS-GTEV-------------------x GxxAG----SPA-------------------------------------- -------------------------------------------------S SxAPSTSSRQYTRQRITRVNLRDLIFYMEQERETAHSLLLYRALLK >ENSSPAP00000004006 -------------------------------------------------- -------MAGASDPLEDMLF--SEVDEKAVSDLVGSLESQLAGQSNPVxx xxxxxxxxxxxxxxxxxxxxLxxx--xxxxxxx----------------- -------------------------------------------------- ------------------------------------x------------- ----QQQ------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxx-xxxxxxxxxxxxxxPSLxCTxS FGEPSTTSxxxxxxxxxxx------------------------------- ----------------------------------------------QSHG AS-xxxx---------------------------xxxxxxxxx------- -------------------------------------------------- -----------------------x-xxxxxx-xx---------------- -------------------------------------------------- -------------------------------------------------- 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-------------------------------------------------- -----------------xxxxxx-------------------------xx Axxxx--------------------------------xxxPVVM------ -----------------------------------------xxxx-PAQA ASQPV--------------------------------------------- ----xxxxxxxxxxxxx---PVVSQEMQENVKKCKNFLATLIKLASHNSP SPETSKNVKALVQDLLDAKIEPEEFTSRLQTELKSSPQPYLVPFLKKSLP ALRLSLLNSQQSLTx----------------------x------------ ---------------xxQxxx----------------------------- ---xA-Px----------------------------------------xx xxxxxxGPAVRIRHP---------------------------------NS VSTxxxxxxxxxGTxxx--------------xAAx--------------- -------------------------------------------------- -------------------G--------------------VKTG-GAVGG QVRMPVVITQSIRAQ----------------------------------- -----------GTM-G--------KGAIIQAGKSPMGLPVQISGNQKNKL NDPGGGSFRDDDDINDVASMAGVNLNEESARILATNSELVGTQIRSCKDE AFLHPGLLHRRILETAKKFGVTEVPMEAVTFISHAAQSRLRTVVEKVSTI AQHRLDSCKDDEC--YEQSADVRSQLRFFEQLERIEKQRKDEQEREILLK AAK---------------SRSRQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKVDSPGATPS-GTEV-------------------x GxxAG----SPA-------------------------------------- -------------------------------------------------S SxAPSTSSRQYTRQRITRVNLRDLIFYMEQERETAHSLLLYRALLK >ENSMAMP00000007307 -------------------------------------------------- -------MAGASDPLEDMLF--SEVDEKAVSDLVGSLESQLAGQSNPAxx xxxxxxxxxxxxxxxxxxxxLxxx--xxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- ----xxx------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxx-xxxxxxxxxxxxxxPALxCAxS FGEPSTTSxxxxxxxxxxx------------------------------- ----------------------------------------------QSHG AS-xxxx---------------------------xxxxxxxxx------- -------------------------------------------------- -----------------------x-xxxxxxxx----------------- -------------------------------------------------- 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CPLTPAKMAPSPS--------------------------------xxxxx xxxxxxxx------------------------------------------ --xxxxxxxxxxxxxxxxxxxxx-------------------------xx AVxxx--------------------------------xxxPMVM------ -----------------------------------------xxxx-PGQA SSQPP--------------------------------------------- ----xxxxxxxxxxxxx---PVVSQEMQENVKKCKNFLATLIKLASHNSP SPETSKNVKALVQDLLDAKIEPEEFTSRLQTELKSSPQPYLVPFLKKSLP ALRLSLLNSQQSLTx----------------------x------------ ---------------xxQxxx----------------------------- ---xA-Px----------------------------------------xx xxxxxxGPAVCIRHP---------------------------------NS VSTxxxxxxxxxGTxxx--------------xAAx--------------- -------------------------------------------------- -------------------G--------------------IKTA-GAVGG QVRMPMVITQSVRTQ----------------------------------- -----------GTM-G--------KGAVIQAGKSPVGLAVQISGNQKNKL NDPGGGSFRDDDDINDVASMAGVNLNEESARILATNSELVGTQIRSCKDE AFLHPGLLHRRILETAKKFGVTDIPMETVTFISHATQSRLRTVVEKVSAI AQHRLDSCKDDEC--YEQSADVRSQLRFFEQLERIEKQRKDEQEREILLK AAK---------------SRSRQEDPEQARLKQKAKELQQQELAQMRQRD ANLTALAAIGPRKKRKVDSPGATPS-GTEV-------------------x GxxAG----SPA-------------------------------------- -------------------------------------------------S SxAPSTSSRQYTRQRITRVNLRDLIFYMEQERETTHSLLLYRALLK >ENSLCRP00005009583 -------------------------------------------------- -------MAGASDPLEDMLF--SEVDEEAVSDLVGSLESQLAGQSNPAxx xxxxxxxxxxxxxxxxxxxxLxxx--xxxxxxx----------------- -------------------------------------------------- ------------------------------------x------------- ----QQQ------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxx-xxxxxxxxxxxxxxPSSxCAxS FGEPSTTSxxxxxxxxxxx------------------------------- ----------------------------------------------QSHG AS-xxxx---------------------------xxxxxxxxx------- -------------------------------------------------- -----------------------x-xxxxxxxxx---------------- 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AFLHPGLLHRRILETAKKFGVTEVPMEAVTFISHATQSRLRTVVEKVSTI AQHRLDSCKDDEC--YEQSADVRSQLRFFEQLERIEKQRKDEQEREILLK AAK---------------SRSRQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKVDSPGATPS-GTEV-------------------x GxxAG----SLA-------------------------------------- -------------------------------------------------S SxTPSTSSRQYTRQRITRVNLRDLIFYMEQERETAHSLLLYRALLK >ENSATEP00000005135 -------------------------------------------------- -------MAGASDPLEDMLF--SEVDEKAVSDLVGSLESQLAGQSNPAxx xxxxxxxxxxxxxxxxxxxxIxxx--xxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- ----xxx------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxx-xxxxxxxxxxxxxxPPLxCTxS FGDPSTTSxxxxxxxxxxx------------------------------- ----------------------------------------------QSHG AS-xxxx---------------------------xxxxxxxxx------- -------------------------------------------------- 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NDPGGGSFRDDDDINDVASMAGVNLNEESARILATNSELVGTQIRSCKDE AFLHPGLLHRRILETAKKFGVTEISMEAVTFISHATQSRLRTVVEKVSAI AQHRLDSCKDDEC--YEQSADVRSQLRFFEQLERIEKQRKDEQEREILLK AAK---------------SRSRQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKVDSPGATPS-GTEV-------------------x GxxAG----SPA-------------------------------------- -------------------------------------------------S SxAPSTSSRQYTRQRITRVNLRDLIFYMEQERETTHSLLLYRALLK >ENSPNYP00000013490 xxxxxxxxxxx--------------------------------------- --x---xMAGASDPLEDMLF--SEVDEKAVSDLVGSLESQLAGQSNPAxx xxxxxxxxxxxxxxxxxxxxLxxx--xxxxxxx----------------- -------------------------------------------------- ------------------------------------x------------- ----QQQ------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxx-xxxxxxxxxxxxxxPSPxCSxS FGEPSTTSxxxxxxxxxxx------------------------------- ----------------------------------------------QSHG AS-xxxx---------------------------xxx------------- 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----------xGTM-G--------KGAIIQAGKSPMGLPVQITGNQKNKL NDPGGGTFRDDDDINDVASMAGVNLNEESARILATNSDLVGTQIRSCKDE AFLHPGLLHRRIQETAKKFGITEVPMETVTFISHATQSRLRTVVEKVSTI AQHRLDSCKDDEC--YEQSADVRSQLRFFEQLERIEKQRKDEQEREILLK AAK---------------SRSRQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKVDSPGATPS-GTE--------------------- ------------xxx----------------------------------- ------------------------------------------xxxxxxxS SSAPSTSSRQYTRQRITRVNLRDLIFYMEQERETAHSLLLYRALLK >ENSHBUP00000019149 -------------------------------------------------- -------MAGASDPLEDMLF--SEVDEKAVSDLVGSLESQLAGQSNPAxx xxxxxxxxxxxxxxxxxxxxLxxx--xxxxxxx----------------- -------------------------------------------------- -----------------------------------xx------------- ----QQQ------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxx-xxxxxxxxxxxxxxPSPxCSxS FGEPSTTSxxxxxxxxxxx------------------------------- ----------------------------------------------QSHG 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LGQLVMVPQ--------------------------------QAL----xx xxxx------------xxAQA--------QAQ-AQ--------------N NISPRPATPTTGTSFRVTSPQx---------------------------- ---------------------------------------S-PVTSQTSRQ CPLTPAKMAPSPS--------------------------------xxxxx xxxxx-xx------------------------------------------ --xxxxxxxxxxxxxxxxxxxxx-------------------------xx AVxxx--------------------------------xxxPVVL------ -----------------------------------------xxxx-PAQP ASQPV--------------------------------------------- ----xxxxxxxxxxxxx---SVASQEMQENVKKCKNFLATLIKLASHNSP SPETSKNVKALVQDLLDAKIEPEEFTSRLQTELKSSPQPYLVPFLKKSLP ALRLSLLNSQQSLIx----------------------x------------ ---------------xxQxxx----------------------------- ---xA-Px----------------------------------------xx xxxxxxGPAVRIRHP---------------------------------NS VSTxxxxxxxxxGTxxx--------------xAAx--------------- -------------------------------------------------- -------------------G--------------------VKTG-GAVGG 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-------------------------------------------------- -------------------G--------------------VKTG-GAVGG QVRMPVVITQSIRAQ----------------------------------- -----------GTM-G--------KGAIIQAGKSPMGLPVQITGNQKNKL NDPGGGTFRDDDDINDVASMAGVNLNEESARILATNSDLVGTQIRSCKDE AFLHPGLLHRRIQETAKKFGITEVPMETVTFISHATQSRLRTVVEKVSTI AQHRLDSCKDDEC--YEQSADVRSQLRFFEQLERIEKQRKDEQEREILLK AAK---------------SRSRQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKVDSPGATPS-GTEV-------------------x GxxAG----SPA-------------------------------------- -------------------------------------------------S SxxPSTSSRQYTRQRITRVNLRDLIFYMEQERETAHSLLLYRALLK >ENSONIP00000003617 -------------------------------------------------- -------MAGASDPLEDMLF--SEVDEKAVSDLVGSLESQLAGQSNPAxx xxxxxxxxxxxxxxxxxxxxLxxx--xxxxxxxx---------------- -------------------------------------------------- -----------------------------------xx------------- ----QQQ------------------------------------------- -------------------------------------------------- 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VSTxxxxxxxxxGTxxx--------------xAAx--------------- -------------------------------------------------- -------------------G--------------------VKTG-GAVGG QVRMPVVITQSIRAQ----------------------------------- -----------GTM-G--------KGAIIQAGKSPMGLPVQITGNQKNKL NDPGGGTFRDDDDINDVASMAGVNLNEESARILATNSDLMGTQIRSCKDE AFLHPGLLHRRIQETAKKFGITEVPMETVTFISHATQSRLRTVVEKVSTI AQHRLDSCKDDEC--YEQSADVRSQLRFFEQLERIEKQRKDEQEREILLK AAK---------------SRSRQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKVDSPGATPS-GTEV-------------------x GxxAG----SPA-------------------------------------- -------------------------------------------------S SSAPSTSSRQYTRQRITRVNLRDLIFYMEQERETAHSLLLYRALLK >ENSBSLP00000028507 -------------------------------------------------- -------MAGASDPLEDMLF--SEVDEKAVSDLVGSLESQLAGQSNPAxx xxxxxxxxxxxxxxxxxxxxLxxx--xxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- ----xxx------------------------------------------- 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-------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxx----------------- ------xxxxxxTTxxxx--------------------xxxTISMVRPxx xxxxxxx-xxxx---------------------------xx-xP-RPGL- AA--PQRIVAPQ--LIVRP-SQQQATIQ--LPPGFTI---PPGMVLVRTE LGQFVMVPQ--------------------------------QALxxxxxx xxxx------------AQAQA--------QAQ-AQ--------------N NISPRPATPTTGTSFRVTTPQ----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxx-------------------------xx Axxxx--------------------------------xxxPVVM------ -----------------------------------------xxxx-PAQS TSQPV--------------------------------------------- ----xxxxxxxxxxxxx---PVVSQEMQENVKKCKNFLATLIKLASHNSP SPETSKNVKALVQDLLDAKIEPEEFTSRLQTELKSSPQPYLVPFLKKSLP ALRLSLLNSQQSLTx----------------------x------------ ---------------xxQxxx----------------------------- ---xA-Ax----------------------------------------xx xxxxxxGPAVRIRHP---------------------------------NS VSTxxxxxxxxxGTxxx--------------xAAx--------------- -------------------------------------------------- -------------------G--------------------VKTG-GVVGG QVRMPMVITQSIRPQ----------------------------------- -----------GTI-G--------KGAIIQTGKSPMGLPVQISGNQKNKL NDPGGGSFRDDDDINDVASMAGVNLNEESARILATNSELVGTQIRSCKDE AFLHPGLLHRRILETAKKFGVTEVSMEAVTFISHATQSRLRTVVEKVSVI AQHRLDSCKDDEC--YEQTGDVRSQLRFFEQLERIEKQRKDEQEREILLK AAK---------------SRSRQEDPEQARLKQKAKEMQQQEEAQMRQRD ANLTALAFIGPRKKRKLDSPGTTPS-GSEV-------------------x GxxAG----SPA-------------------------------------- -------------------------------------------------G SxAPSTSSRQYTRQRITRVNLRDLIFYMEQERETAHSLLLYRALLK >ENSXCOP00000016807 xxxxxxxxxxx--------------------------------------- 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TSQPA--------------------------------------------- ----xxxxxxxxxxxxx---PVVSQEMQENVKKCKNFLATLIKLASHNSP SPETSKNVKALVQDLLDAKIEPEEFTSRLQSELKSSPQPYLVPFLKKSLP ALRLSLLNSQQSLTx----------------------x------------ ---------------xxQxxx----------------------------- ---xA-Ax----------------------------------------xx xxxxxxGPAVRIRHP---------------------------------NS VSTxxxxxxxxxGTxxx--------------xAAx--------------- -------------------------------------------------- -------------------G--------------------VKTG-GTVSG PVRMPMVITQSIRPQ----------------------------------- -----------GMI-G--------KGAIIQAGKSPMGLPVQISGNQKNKL NDPGGGSFRDDDDINDVASMAGVNLNEESARILATNSELVGTQIRSCKDE AFLQPGLLHRRILETAKKFGVTEVPMEAVTFISHAAQSRLRTVVQKVSII AQHRIDSCKDDEC--YEQSADVRSQLRFFEQLERIEKQRKDEQEREILLK AAK---------------SRSRQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKLDSPGATPS-GTEV-------------------x SxxAG----SPG-------------------------------------- -------------------------------------------------C SxTPSTSSRQYTRQRITRVNLRDLIFYMEQERETAHSLLLYRALLK >ENSGAFP00000013995 -------------------------------------------------- -------MAGASDPLEDMLF--SEVDEKAVSDLVGSLESQLSGQSNSAxx xxxxxxxxxxxxxxxxxxxxLxxx--xxxxxxx----------------- -------------------------------------------------- ------------------------------------x------------- ----xQx------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxxxxx-xxxxxxxxxxxxxxPQLxCSxS FGEPPSSSxxxxxxxxxxx------------------------------- ----------------------------------------------QSHG AS-xxxx---------------------------xxxxxxxxx------- -------------------------------------------------- -----------------------x-xxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxxxxxxEx xxxxxxxxxxxxxxxxxxxxxxxxLNGxxxxxxxxx-------------- ------------------------------------xxxxxxxxxxxxxx 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AVxxx--------------------------------xxxPMAI------ -----------------------------------------xxxx-QAQP TSQPA--------------------------------------------- ----xxxxxxxxxxxxx---PVVSQEMQENVKKCKNFLATLIKLASHNSP SPETSKNVKALVQDLLDAKIEPEEFTSRLQTELKSSPQPYLVPFLKKSLP ALRLSLLNSQQSLTx----------------------x------------ ---------------xxQxxx----------------------------- ---xA-Ax----------------------------------------xx xxxxxxGPAVRIRHP---------------------------------NS VSTxxxxxxxxxGTxxx--------------xAAx--------------- -------------------------------------------------- -------------------G--------------------VKTG-GTVSG PVRMPMVITQSIRPQ----------------------------------- -----------GTI-G--------KGAIIQAGKSPMGLPVQISGNQKNKL NDPGGGSFRDDDDINDVASMAGVNLNEESARILATNSELVGTQIRSCKDE AFLHPGLLHRRILETAKKFGVTEVPMEAVTFISHAAQSRLRTVLEKVSII AQHRIDSCKDDEC--YEQSADVRSQLRFFEQLERIEKQRKDEQEREILLK AAK---------------SRSRQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKLDSPGATPS-GTEV-------------------x 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ANLTALAAIGPRKKRKMDSPGATPS-GTEV-------------------x GxxAG----SPA-------------------------------------- -------------------------------------------------S SxTPSNSSRQYTRQRITRVNLRDLIFYMEQERATAHSLLLYRALLK >ENSTRUP00000040346 -------------------------------------------------- -------MAGTSDPLEDMLF--SEVDEKAVSDLVGSLESQLAGQSKPAxx xxxxxxxxxxxxxxxxxxxxLxxx--xxxxxxx----------------- -------------------------------------------------- ------------------------------------x------------- ----QQQ------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxx-xxxxxxxxxxxxxxPSQxCSxP FGEPSTTSxxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxx--------xxxxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- 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--xxxxx-xxxxxx----------------------------xx-RPGLx AS--PTRAAAPQLxLAVRP--QQQTTIQ--LPPGFTM---PPGMVLVRTE TGQLVMVPQ--------------------------------QVL------ ----------------AQAQAxxx-----QAQ-TV--------------T NIAQRPATPTAGATIRVSTAT----------------------------- --------------------------------------TV-PGTPQTVRL ASPAPTRMVQSPSST----------------------------------- -xxx-----------------------------------xxx-------- --------------------xxxxxxxxxx-------------------- KMxxx--------------------------------xxxPTVIxxx--- ----------------------------------------xxxxxxPAxx xxxxL----------Txxxx------------------------------ -xx--------xxxxxx-xxTVVSQEMQENVKKCKNFLATLIKLASHNSP SPDTSKNVKALVQDLLDAKIEPEEFTTRLQAELKSSPQPYLIPFLKKSLP ALRQSLLSSQQSLMTxx--------------------xxxxx-------- ---xx--------------------------------------------- ---xxxxx---------xxxx----------------------------- -------AAIRPRLPxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------A--------------------VGRP-GVQTV QTRTPIVIGQTLRPQ----------------------------------- -----------GTL-I--------RGPTTIIGKSVVNLTAQ--ANQK-KL SDPGGGTFRDDDDINDVASMAGVNLNEENARILATSSELVGTKIRSCKDE SFLPTGLLHRRILDSAKKLGVTEVPLEVVNFISHATQSRLRSLLEKVSAV AQHRTDGGKDEEH--YEQSSDVRSQLRFFEQLERMEKQRKDEQEREILLK AAK---------------SRARQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKLDSPGGA-A-ATEV-------------------- --xxx----xxx-------------------------------------- -------------------------------------------------x xx-SSSSSRQQLRQRITRVNLRDFIFCLEQDRSTARSLMLYKALLK >ENSMAMP00000023993 -------------------------------------------------- -------MAGASDPLEDMLF--NEVDEKAVSDLVGSLESQLGDRKTPA-- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxx-xxxxx-------xx------------- ----xxQxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---QTVG AP------x----------------------------------------- -------------------------------------------------- -------------------------x------------xxxxx------- -------------------------------------------------- ---------------xxxxxxxxxxx-xxxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- --------------xxxxxxxxxSLNG----------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxx----- ----------------------------------------------xxx- -------------------------------------------------- ------------xx------------------xxxx--xxxxxxxxxxxx xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- PTFP-------VxxxSx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxA----------------------------LQG----HPxP-x ASVAQNG---------x-xxxxxx---xxTQGx----------------- ------------------------------------------------xx xxxxxxxVMxxxx-------------------------xxxxxxxxxx-- -------------------------------------------------- ----------------------------xxxxxxx-xxxxxxx--x---- ---------xxxxxxxxxxxxxxxxx------------x----------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxx----------------------------------------- --------------------------------------------x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------TVAVVRP-- --xxxxx-xxxxxx----------------------------xx-RPGLx VS--STRAAAPQAxLAVRP--QQQTTIQ--LPPGFTM---PAGMVLVRTE TGQLVMVPQ--------------------------------QVL------ ----------------AQAQAxxx-----QSQ-TV--------------A NITQRPATATAGAAIRVSTTT----------------------------- --------------------------------------TA-PGAPQTVRL ASPTQPRMVQSPATT----------------------------------- -xxx-----------------------------------xxx-------- --------------------xxxxxxxxxx-------------------- KMxxx--------------------------------xxxPTVIxxx--- ----------------------------------------xxxxxxPAxx xxxxL----------Txxxx------------------------------ -xx--------xxxxxx-xxTVLSQEMQENVKKCKNFLATLIKLASHNSP SPDTSKNVKALVQDLLDAKIEPEEFTTRLQAELKSSPQPYLIPFLKKSLP ALRQSLLSSQQSLMTxx--------------------xxxxx-------- ---xx--------------------------------------------- ---xxxxx---------xxxx----------------------------- -------TTIRPRLPxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------P--------------------VSRP-GFQTV QTRTPVVISQTLRPQ----------------------------------- -----------GTL-I--------RGPTTIISKCSVNLAAA--ANQK-KL SDPGGGTFRDDDDINDVASMAGVNLNEENARILATSSELVGTKIRSCKDE SFLPTGLLHCRILDTAKKLGVTEVPLEVVNLISHATQSRLRSLLEKVSAI AQHRADGGKDEEL--HEQTSDVRSQLRFFEQLERMEKQRKDEQEREILLK AAK---------------SRARQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKVDSPGG----GTEV-------------------- --xxx----xxx-------------------------------------- -------------------------------------------------x xx-PAASSRQQPRQRITRVNLRDFIFCLEQDRTTARSLMLYKALLK >ENSATEP00000020103 -------------------------------------------------- -------MAGASDPLEDMLF--NEVDEKAVSDLVGSLESQLGDRKSAA-- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxx-xxxxx-------xx------------- ----xxQxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---QVVG AS------------------------------------------------ -------------------------------------------------- ----------------------------------------xxx------- -------------------------------------------------- ---------------xxxxxxxxxxx-xxxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- --------------xxxxxxxxxSL------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx x------------------------------------xxxxxxxxxxxx- -------------------------------------------------- ------------x------------------------------------- ---xxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- PGFP-------VxxxSx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxT----------------------------LQR----HPxP-x VSVAQNG---------x-xxxxxx---xxTQGx----------------- ------------------------------------------------xx xxxxxxxIMxxxx-------------------------xxxxxxxxxx-- -------------------------------------------------- ----------------------------xxxxxxx-xxxxxxx--x---- ---------xxxxxxxxxxxxxxxxx------------xx-xxx------ -------------------------------------------------- ----------------------------------xx-------------- ----------------------------------------------xxxx xxxxxxxxx----------------------------------------- --------------------------------------------x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------AVAVVRx-- --xxxxx-xxxxxx----------------------------xx-RPGLx AS--PTRAAAPQPxLAVRP--QQQTTIQ--LPPGFTM---PPGMVLVRTE TGQLVMVPQ--------------------------------QVL------ ----------------AQAQAxxx-----xxx-xx--------------- -VTQRPATPTAGATIRVSSAP----------------------------- --------------------------------------TG-PGTPATVRL ASPAQTRMVQSPSTT----------------------------------- -xxx-----------------------------------xxx-------- --------------------xxxxxxxxxx-------------------- KMxxx--------------------------------xxxQTVIxxx--- ----------------------------------------xxxxxxPVxx xxxxM----------Txxxx------------------------------ -xx--------xxxxxx-xxTVVSQEMQENVKKCKNFLSTLIKLASHNSP SPETSKNVKALVQDLLDAKIEPEEFTTRLQAELKSSPQPYLIPFLKKSLP ALRQSLLSSQQSLVTxx--------------------xxxxx-------- ---xx--------------------------------------------- ---xxxxx---------xxxx----------------------------- -------AAIRPRLPxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------A--------------------VSR--xVQTV QPRTPVVISQTFRPQ----------------------------------- -----------GTL-V--------RAPTTIIGKSTLHLVAP--ANQK-KL SDPGGGTFRDDDDINDVASMAGVNLNEENARILATSSEIVGTKIRSCKDE SFLPTGLLHCRILNTAKKLGVTEVPLDVVNLISHATQSRLRSLLEKVSAV AQHRTDGGKDEEH--YEQSSDVRSQLRFFEQLERMEKQRKDEQEREILLK AAK---------------SRARQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKLDSPGGAGA-GAEV-------------------- --xxx----xxx-------------------------------------- -------------------------------------------------x xx-TAASSRQQLRQRITRVNLRDFIFCLEQDRGSARSLMLYKALLK >ENSLCRP00005027149 -------------------------------------------------- -------MAGASDPLEDMLF--TEVDEKAVSDLVGSLESQLGDRKLPA-- -------------------------------------------------- ------------------------------------------------x- xxxxxxxxxxxxxxxxxxxxxx-xxxxx--------x------------- ----xxQxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---QTVG AS------x----------------------------------------- -------------------------------------------------- -------------------------x------------xxxxx------- -------------------------------------------------- ---------------xxxxxxxxxxx-xxxxxx--------xxxxxxxxx xxx----------------------------------------------- --------------xxxxxxxxxTLNG----------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxx----- ----------------------------------------------xxx- -------------------------------------------------- ------------xx------------------xxxx--xxxxxxxxxxxx xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- PAFP-------Vxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxA----------------------------LQR----HPxx-x x---QNG---------x-xxxxxx---xxxxxx----------------- -------------------------------------------------- xxxxxxxVVxxxx-------------------------xxxxxxxxxx-- -------------------------------------------------- ----------------------------xxxxxxx-xxxxxxx--x---- ---------xxxxxxxxxxxxxxxxx------------xx-xxx------ -------------------------------------------------- ----------------------------------xx-------------- ----------------------------------------------xxxx xxxxxxxxx----------------------------------------- --------------------------------------------x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------TVTVVRP-- --xxx-x-xxxxxx----------------------------xx-RPGLx VS--STRAAAPQPxLAVRP--QQQTTIQ--LPPGFTM---PPGMVLVRTE TGQLVMVPQ--------------------------------QVL------ ----------------AQAQAxxx-----QGQ-TV--------------T NITQRPTTPTAGATIRGSTA------------------------------ --------------------------------------------PQTVRL ASPAQTRMVQSPSTT----------------------------------- -xxx----------------------------------xxxx-------- --------------------xxxxxxxxxx-------------------- KMxxx--------------------------------xxxQTVIxxx--- ----------------------------------------xxxxxxP--x xxxxL----------Txxxx------------------------------ -xx--------xxxxxx-xxTVVSQEMQENVKKCKNFLATLIKLASHNSP SPDTSKNVKALVQDLLDAKIEPEEFTTRLQAELKSSPQPYLIPFLKKSLP ALRQSLLSSQQSLV--x--------------------xxxxx-------- ---xx--------------------------------------------- ---xxxxx---------xxx------------------------------ --------AIRPRLPxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------GRT-GVQTV QTRTPVVFSQTLRPQ----------------------------------- -----------GTL-I--------RGPTAVIGKSPIHLAAQ--ANQK-KL SDPGGGTFRDDDDINDVASMAGVNLNEENARILATSSELVGTKIRSCKDE SFLPTGLLHCRILDTAKKLGVSEVPLEVVNFISHATQSRLRSLLEKVSTV AQHRTDGGKDEEH--HEQTTDVRSQLRFFEQLERLEKQRKDEQEREILLK AAK---------------SRARQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKMDSPGGAAS-GSEV-------------------- --xxx----xxx-------------------------------------- -------------------------------------------------x xx-AASSSRQQLRQRITRVNLRDFIFCLEQDRSTARSLTLYKALLK >ENSLBEP00000013694 -------------------------------------------------- -------MAGASDPLEDMLF--NEVDEKAVSDLVGSLESQLGDRKAPG-- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxx-xxxxx--------x------------- ----xxQxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---QTVG AS------------------------------------------------ -------------------------------------------------- -------------------------x------------xxxxx------- -------------------------------------------------- ---------------xxxxxxxxxxx-xxxxxxxxxxx----xxxxxxxx xxx----------------------------------------------- --------------xxxxxxxxxSLNG----------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxx----- ----------------------------------------------xxx- -------------------------------------------------- ------------xx------------------xxxx--xxxxxxxxxxxx xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- PGFPxxxxxxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxP----------------------------LQR----HTxx-x x---QNG---------x-xxxxxx---xxxxxx----------------- ------------------------------------------------xx x-----xVLxxxx-------------------------xxxxxxxxxx-- -------------------------------------------------- ----------------------------xxxxxxx-xxxxxxx--x---- ---------xxxx-xxxxxxxxxxxx------------x----------- -------------------------------------------------- -----------------------------------x-------------- ----------------------------------------------xxxx xxxxxxxxx----------------------------------------- --------------------------------------------x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------TVALVRP-- --xxxxx-xxxxxx----------------------------xx-RPGLx AT--PTRAAAPQPxIAVRP--QQQTTIQ--LPPGFSM---PPGMVLVRTE TGQLVMVPQ--------------------------------QVL------ ----------------AQAQAxxx-----QSQ-TV--------------S NITQRPATPTAAATIRVSTAS----------------------------- --------------------------------------xx----PQTVRL ATPAQTRMVHSPSTN----------------------------------- -xxx----------------------------------xxxx-------- --------------------xxxxxxxxxx-------------------- KMxxx--------------------------------xxxQTVIxxx--- ----------------------------------------xxxxxxPAxx xxxxH----------Txxxx------------------------------ -xx--------xxxxxx-xxTVVSQEMQENVKKCKNFLATLIKLASHNSP SPDTSKNVKALVQDLLDAKIEPEEFTTRLQAELKSSPQPYLIPFLKKSLP ALRQSLLSSQQSLV--x--------------------xxxxx-------- ---xx--------------------------------------------- ---xxxxx---------xxxx----------------------------- -------TAIRPRLPxxxxxxxxxxxxxxxxx--x--------------- -------------------------------------------------- -------------------------------------------------- -------------------A--------------------VNRA-GAQSV QTRSPVVFSQSIRPQ----------------------------------- -----------GNI-V--------RGPTTIIGKSPVNLAAQ--ANQR-KL SDPGGGTFRDDDDINDVASMAGVNLNEENARILATSSELVGTKIRSCKDE SFLPTGLLHRRILDTAKKLGVSEVPLEVVNFISHATQSRLRSLLEKVSAV AQHRSDGGKDEEH--HEPTSDVRSQLRFFEQLERMEKQRKDEQEREILLK AAK---------------SRARQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKMDSPGGSTA-GTEV-------------------- --xxx----xxx-------------------------------------- ------------------------------------------------xx Sx-xxxxSRQQLRQRITRVNLRDFIFCLEQDRTTARSLTLYKALLK >ENSPRNP00000026443 -------------------------------------------------- -------MAGASDPLEDMLF--NEVDEKAVSDLVGSLESQLGDRKPLP-- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxx-xxxxx-------xx------------- ----xxQxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxx---xxxxxxxxxx---QTVG AP------x----------------------------------------- -------------------------------------------------- -------------------------x------------xxxxx------- -------------------------------------------------- ---------------xxxxxxxxxxx-xxxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- --------------xxxxxxxxxSLNG----------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxx----- ----------------------------------------------xxx- -------------------------------------------------- ------------xx------------------xxxx--xxx---xxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- PSFP-------VxxxSx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxA----------------------------LQG----HPxP-x TSVAQNG---------x-xxx----------xx----------------- ------------------------------------------------xx xxxxxxxVMx-xx-------------------------xxxxxxxxxx-- -------------------------------------------------- ----------------------------xxxxxxx-xxxxxxx--x---- ---------xxxxxxxxxxxxxxxxxxxxxxx------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxx----------------------------------------- --------------------------------------------x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------TVAVVRA-- --xxxxx-xxxxxx----------------------------xx-RPGLx AG--SPRAATPQPxLAVRP--QQQATIQ--LPPGFTM---PPGMVLVRTE TGQLVMVPQ--------------------------------QVL------ ----------------AQAQAxxx-----QGQ-TV--------------T NIAQRPATPTAGSTIRVSTAT----------------------------- --------------------------------------TA-PGTPQTVRL ASPAQTRMVQSPATT----------------------------------- -xxx-----------------------------------xxx-------- --------------------xxxxxxxxxx-------------------- xx--x--------------------------------xxxPTVIxxx--- ----------------------------------------xxxxxxPAxx xxxxL----------Txxxx------------------------------ -xx--------xxxxxx-xxTVVSQEMQENVKKCKNFLATLIKLASHNSP SPETSKNVKALVQDLLDAKIEPEEFTTRLQAELKSSPQPYLIPFLKKSLP ALRQSLLSSQQSLITxx--------------------xxxxx-------- ---xx--------------------------------------------- ---xxxxx---------xxxx----------------------------- ---------IRPRLPxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------A--------------------AGR--xVQAV PTRSPIVISQPLRPQ----------------------------------- -----------SAF-V--------RGPMTIAGKTSINLAAQ--ANQK-KL SDPGGGTFRDDDDINDVASMAGVNLNEENARILATSSEIVGTKIRSCKDE SFLPTGLLHRRVLDTAKKLGVSEVPLDVVSFISHATESRLRSLLEKVSAI AQHRADGGKDEQH--HEQTSDARSQLRFFEQLERMEKQRKDEQEREMLLK AAK---------------SRARQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKLDSPGAATS-GTEV-------------------- --xxx----xxx-------------------------------------- -------------------------------------------------x xx-TAAGSRQQLRQRITRVNLRDFIFCLEQDRSTTRSLMLYKALLK >ENSAOCP00000001835 -------------------------------------------------- -------MAGASDPLEDMLF--TEVDEKAVSDLVGSLESQLGDRNTPA-- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxx-xxxxx--------x------------- ----xxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxx-xxxxxxxxxxxx---PAAG AA------x----------------------------------------- -------------------------------------------------- -------------------------x------------xxxxx------- -------------------------------------------------- ---------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxx--------------------------------------------- --------------xxxxxxxxxSLNG----------------------- -------------------------------------------------- ------------------------------------xxxxxxxxx----- ----------------------------------------------xxx- -------------------------------------------------- ------------xxxx---------------xxxxx--xxxx----xxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- PSFP------------x--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxA----------------------------LQR----LPxP-x TSVAQNG---------x-xxxxxx---xx--------------------- -------------------------------------------------x xxxxxxxVLxxxx-------------------------xxxxxxxxxx-- -------------------------------------------------- ----------------------------xxxxxxx-xxxxxxx--x---- ---------xx-xxxxxxxxxxxxxx------------xxxxxx------ -------------------------------------------------- ----------------------------------xx-------------- -------------------------------------------------- xxxxxxxxx----------------------------------------- --------------------------------------------x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------AVAVVRP-- --xxxxx-xxxxxx----------------------------xx-RPGLx AA---xRPAAPQPxLAVRP--QQQTTIQ--LPPGFTM---PPGMVLVRTE AGQLVMVPQ--------------------------------QVL------ ----------------AQAQAxxx-----QGQ-TV--------------A NISPRPTAPTAGATIRVSTAT----------------------------- --------------------------------------xA-PGx-QTVRL ASPTQPRMVQSPATT----------------------------------- -xxx----------------------------------xxxx-------- --------------------xxxxxxxxxx-------------------- KM-xx--------------------------------xxxPTVIxxx--- ----------------------------------------xxxxxxPTxx xxxxM----------Txxxx------------------------------ -xx--------xxxxxx-xxSVVSQEMQENVKKCKNFLATLIKLASHNSP SPDTSKNVKALVQDLLDAKIEPEEFTTRLQAELKSSPQPYLIPFLKKSLP ALRQSLLSSQQSLMTxx--------------------xxxxx-------- ---xx--------------------------------------------- ---xxxxx---------xxxx----------------------------- ------GATIRPRLPxxxxxxxxxxxxxx-xxxxx--------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxx-x---V QTRSPVVISQTFRPA----------------------------------- -----------GTL-I--------RGPTTIAGKTPVNLTAQ--ANQK-KL SDPGGGTFRDDDDINDVASMAGVNLNEENARILATSSELVGTKIRSCKDE SFLPTGLLHRRILDTAKKLGVTEVPLEVVNFVSHATQSRLRSLLERVSAV AQHRTDGGKDEEL--HEQTSDVRSQLRFFEQLERMEKQRKDEQEREMLLK AAK---------------SRARQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKLDSPG-xxx-GNEV-------------------- --xxx----xxx-------------------------------------- -------------------------------------------------x xxxPASSSRQQVRQRITRVNLRDFIFCLEQDRGTARSLMLYKALLK >ENSMZEP00005027512 -------------------------------------------------- -------MAGASDPLEDMLF--NEVDEKAVSDLVGSLESQLGDRKPPA-- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxx-xxxxx--------x------------- ----xxQxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------VG PP------x----------------------------------------- -------------------------------------------------- -------------------------x------------xxxxx------- -------------------------------------------------- ---------------xxx--xxxxxx-xxxxxxxxxxxxx---------x xxx----------------------------------------------- --------------xxxxxxxxxSVNG----------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxx----- ----------------------------------------------xxx- -------------------------------------------------- ------------xx------------------xxxx------------xx -----xxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- PGFP-------VxxxSx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxV----------------------------LQR----LPxx-- --xAQNG---------x-xxxxxx---xx--------------------- -------------------------------------------------x xxxxxxxVVxxxx-------------------------xxxxxxxxxx-- -------------------------------------------------- ----------------------------xxxxxxx-xxxxxxx--x---- ---------xx--xxxxxxxxxxxxxxxxx-------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxx----------------------------------------- --------------------------------------------x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------AVAVVRP-- --xxxxx-xxxxxx----------------------------xx-RPGLx AA--TTRVATSQPxLAVRP--QQQTTIQ--LPQGFTM---PQGMVLVRTE TGQLVMVPQ--------------------------------QVL------ ----------------AQAQAxxx-----QSQ-AV--------------T SITQRPATPTAGTTIRVSTAP----------------------------- --------------------------------------TA-PGTPQTVRL ATPTQTRMIQPPSTT----------------------------------x -xxx----------------------------------xxxx-------- --------------------xxxxxxxxxx-------------------- KMxxx--------------------------------xxxPTVIxxx--- ----------------------------------------xxxxxxPAxx xxxxM----------Tx-xx------------------------------ -xx--------xxxxxx-xxTVVSQEMQENVKKCKNFLATLIKLASHNSP SPDTSKNVKALVQDLLDAKIEPEEFTTRLQAELKSSPQPYLIPFLKKSLP ALRQTLLNSQQSLMTxx--------------------xxxxx-------- ---xx--------------------------------------------- ---xxxxx---------xxxx----------------------------- -------ATIRPRLPxxxxxxxxxxxxxxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------P--------------------VCRP-GVQTV QARAPIV----FRPQ----------------------------------- -----------ATLxV--------RGPTTIISKSPVNLAAQ--ANQK-KL SDPGGGTFRDDDDINDVASMAGVNLNEENARILATSSELVGTKIRSCKDE AFLPSGLLLRRILDTAKKFGVSEVPPEVVNLVSHATQSRLRTLLEKVSAI AQHRTDGGKDEER--YEQTSDVRSQLRFFEQLERLEKQRKDEQEREMLLK AAK---------------SRARQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKLDSPGG--x-GTEV-------------------- --xxx----xxx-------------------------------------- -------------------------------------------------x xx-VAGSSRQQPRQRITRVNLRDLIFCMEHDRPTARSLILYKALLK >ENSACLP00000031851 -------------------------------------------------- -------MAGASDPLEDMLF--NEVDEKAVSDLVGSLESQLGDRKPPA-- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxx-xxxxx--------x------------- ----xxQxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------VG PP------x----------------------------------------- -------------------------------------------------- -------------------------x------------xxxxx------- -------------------------------------------------- ---------------xxx--xxxxxx-xxxxxxxxxxxxx---------x xxx----------------------------------------------- --------------xxxxxxxxxSVNG----------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxx----- ----------------------------------------------xxx- -------------------------------------------------- ------------xx------------------xxxx------------xx -----xxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- PGFP-------VxxxSx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxV----------------------------LQR----LPxx-- --xAQNG---------x-xxxxxx---xx--------------------- -------------------------------------------------x xxxxxxxVVxxxx-------------------------xxxxxxxxxx-- -------------------------------------------------- ----------------------------xxxxxxx-xxxxxxx--x---- ---------xx--xxxxxxxxxxxxxxxxx-------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxx----------------------------------------- --------------------------------------------x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------AVAVVRP-- --xxxxx-xxxxxx----------------------------xx-RPGLx AA--TTRVATSQPxLAVRP--QQQTTIQ--LPQGFTM---PQGMVLVRTE TGQLVMVPQ--------------------------------QVL------ ----------------AQAQAxxx-----QSQ-AV--------------T SITQRPATPTAATTIRVSTAP----------------------------- --------------------------------------TA-PGTPQTVRL ATPTQTRMIQPPSTT----------------------------------x -xxx----------------------------------xxxx-------- --------------------xxxxxxxxxx-------------------- KMxxx--------------------------------xxxPTVIxxx--- ----------------------------------------xxxxxxPAxx xxxxx----------xx-xx------------------------------ -xx--------xxxxxx-xxTVVSQEMQENVKKCKNFLATLIKLASHNSP SPDTSKNVKALVQDLLDAKIEPEEFTTRLQAELKSSPQPYLIPFLKKSLP ALRQTLLNSQQSLMTxx--------------------xxxxx-------- ---xx--------------------------------------------- ---xxxxx---------xxxx----------------------------- -------ATIRPRLPxxxxxxxxxxxxxxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------P--------------------VCRP-GVQTV QARAPIV----FRPQ----------------------------------- -----------ATLxV--------RGPTTIISKSPVNLAAQ--ANQK-KL SDPGGGTFRDDDDINDVASMAGVNLNEENARILATSSELVGTKIRSCKDE AFLPSGLLLRRILDTAKKFGVSEVPPEVVNLVSHATQSRLRTLLEKVSAI AQHRTDGGKDEER--YEQTSDVRSQLRFFEQLERLEKQRKDEQEREMLLK AAK---------------SRARQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKLDSPGG--x-GTEV-------------------- --xxx----xxx-------------------------------------- -------------------------------------------------x xx-VAGSSRQQPRQRITRVNLRDLIFCMEHDRPTARSLILYKALLK >ENSHBUP00000005744 -------------------------------------------------- -------MAGASDPLEDMLF--NEVDEKAVSDLVGSLESQLGDRKPPA-- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxx-xxxxx--------x------------- ----xxQxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------VG PP------x----------------------------------------- -------------------------------------------------- -------------------------x------------xxxxx------- -------------------------------------------------- ---------------xxx--xxxxxx-xxxxxxxxxxxxx---------x xxx----------------------------------------------- --------------xxxxxxxxxSVNG----------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxx----- ----------------------------------------------xxx- -------------------------------------------------- ------------xx------------------xxxx------------xx -----xxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- PGFP-------VxxxSx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxG----------------------------LQR----LPxx-- --xAQNG---------x-xxxxxx---xx--------------------- -------------------------------------------------x xxxxxxxVVxxxx-------------------------xxxxxxxxxx-- -------------------------------------------------- ----------------------------xxxxxxx-xxxxxxx--x---- ---------xx--xxxxxxxxxxxxxxxxx-------------------- 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----------------------------------------xxxxxxPAxx xxxxM----------Tx-xx------------------------------ -xx--------xxxxxx-xxTVVSQEMQENVKKCKNFLATLIKLASHNSP SPDTSKNVKALVQDLLDAKIEPEEFTTRLQAELKSSPQPYLIPFLKKSLP ALRQTLLNSQQSLMTxx--------------------xxxxx-------- ---xx--------------------------------------------- ---xxxxx---------xxxx----------------------------- -------ATIRPRLPxxxxxxxxxxxxxxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------P--------------------VCRP-GVQTV QARAPIV----FRPQ----------------------------------- -----------ATLxV--------RGPTTIISKSPVNLAAQ--ANQK-KL SDPGGGTFRDDDDINDVASMAGVNLNEENARILATSSELVGTKIRSCKDE SFLPSGLLLRRILDTAKKFGVSEVPPEVVNLVSHATQSRLRTLLEKVSAI AQHRTDGGKDEER--YEQTSDVRSQLRFFEQLERLEKQRKDEQEREMLLK AAK---------------SRARQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKLDSPGG--x-GTEV-------------------- --xxx----xxx-------------------------------------- -------------------------------------------------x xx-VAGSSRQQPRQRITRVNLRDLIFCMEHDRPTARSLILYKALLK >ENSPNYP00000007490 G--------xx-------------------xQRxxxxxxxxxxxxxxxx- --GPASxMAGASDPLEDMLF--NEVDEKAVSDLVGSLESQLGDRKPPA-- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxx-xxxxx--------x------------- ----xxQxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------VG PP------x----------------------------------------- -------------------------------------------------- -------------------------x------------xxxxx------- -------------------------------------------------- ---------------xxx--xxxxx------------------------- -------------------------------------------------- -----------------------SVNG----------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxx----- ----------------------------------------------xxx- -------------------------------------------------- ------------xx------------------xxxx------------xx -----xxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- PGFP-------VxxxSx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxV----------------------------LQR----LPxx-- --xAQNG---------x-xxxxxx---xx--------------------- -------------------------------------------------x xxxxxxxVVxxxx-------------------------xxxxxxxxxx-- -------------------------------------------------- ----------------------------xxxxxxx-xxxxxxx--x---- 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KMxxx--------------------------------xxxPTVIxxx--- ----------------------------------------xxxxxxPAxx xxxxM----------Tx-xx------------------------------ -xx--------xxxxxx-xxTVVSQEMQENVKKCKNFLATLIKLASHNSP SPDTSKNVKALVQDLLDAKIEPEEFTTRLQAELKSSPQPYLIPFLKKSLP ALRQTLLNSQQSLMTxx--------------------x------------ -------------------------------------------------- ------------------xxx----------------------------- -------ATIRPRLPxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------V--------RGPTTIISKSPVNLAAQ--ANQK-KL SDPGGGTFRDDDDINDVASMAGVNLNEENARILATSSELVGTKIRSCKDE AFLPSGLLLRRILDTAKKFGVSEVPPEVVNLVSHATQSRLRTLLEKVSAI AQHRTDGGKDEER--YEQTSDVRSQLRFFEQLERLEKQRKDEQEREMLLK AAK---------------SRARQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKLDSPGG--x-GTEV-------------------- --xxx----xxx-------------------------------------- -------------------------------------------------x xx-VAGSSRQQPRQRITRVNLRDLIFCMEHDRPTARSLILYKALLK >ENSNBRP00000006378 H--------x---------------------QRxxxxxxxxxxxxxxxx- --GPASxMAGASDPLEDMLF--NEVDEKAVSDLVGSLESQLGDRKPPA-- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxx-xxxxx--------x------------- ----xxQxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------VG PP------x----------------------------------------- -------------------------------------------------- -------------------------x------------xxxxx------- -------------------------------------------------- ---------------xxx--xxxxxx-xxxxxxxxxxxxx---------x xxx----------------------------------------------- --------------xxxxxxxxxSVNG----------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxx----- ----------------------------------------------xxx- -------------------------------------------------- ------------xx------------------xxxx------------xx -----xxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- PGFP-------VxxxSx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxV----------------------------LQR----LPxx-- --xAQNG---------x-xxxxxx---xx--------------------- -------------------------------------------------x xxxxxxxVVxxxx-------------------------xxxxxxxxxx-- -------------------------------------------------- ----------------------------xxxxxxx-xxxxxxx--x---- ---------xx--xxxxxxxxxxxxxxxxx-------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxx----------------------------------------- --------------------------------------------x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------TVAVVRP-- --xxxxx-xxxxxx----------------------------xx-RPGLx AA--TTRVATSQPxLAVRP--QQQTTIQ--LPQGFTM---PQGMVLVRTE TGQLVMVPQ--------------------------------QVL------ ----------------AQAQAxxx-----QSQ-AV--------------T SITQRPATPTAATTIRVSAAP----------------------------- --------------------------------------x----------- -------------------------------------------------- -----------------------------------------xxx---xx- -------------------xx----------------------------- -------------------------------------xxxPTVIxxx--- ----------------------------------------xxxxxxPAxx xxxxM----------Tx-xx------------------------------ -xx--------xxxxxx-xxTVVSQEMQENVKKCKNFLATLIKLASHNSP SPDTSKNVKALVQDLLDAKIEPEEFTTRLQAELKSSPQPYLIPFLKKSLP ALRQTLLSSQQSLMTxx--------------------xxxxx-------- ---xx--------------------------------------------- ---xxxxx---------xxxx----------------------------- -------TTIRPRLPxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------V--------RGPTTIISKSPVNLAAQ--ANQK-KL SDPGGGTFRDDDDINDVASMAGVNLNEENARILATSSELVGTKIRSCKDE SFLPSGLLLRRILDTAKKFGVSEVPPEVVNLVSHATQSRLRTLLEKVSAI AQHRTDGGKDEER--CEQTSDVRSQLRFFEQLERLEKQRKDEQEREMLLK AAKxxxxxxxxxxxxxxx-------------------MQQQELAQMRQRD ANLTALAAIGPRKKRKLDSPGG--x-GTEVxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- ----------QPRQRITRVNLRDLIFCMEHDRPTARSLILYKALLK >ENSACIP00000020569 xxxxxxxxxx---------------------Dxxxxxxxxxxxxxxxxx- --GPASxMAGASDPLEDMLF--NEVDEKAVSDLVGSLESQLGDRKPPT-- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxx-xxxxx--------x------------- ----xxQxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---HTVG TP------x----------------------------------------- -------------------------------------------------- -------------------------x------------xxxxx------- -------------------------------------------------- ---------------xxx--xxxxxx-xxxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- --------------xxxxxxxxxxxxx----------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxx----- ----------------------------------------------xxx- -------------------------------------------------- ------------xx------------------xxxx------------xx xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- xGFP-------xxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxx----------------------------xQx----xxxP-V TSVAQNG---------x-xxxxxP---Sx--------------------- -------------------------------------------------x xxxxxxxVVxxxx-------------------------xxxxxxxxxx-- 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-------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx KMxxx--------------------------------xxxTTVIxxx--- ----------------------------------------xxxxxxx--- -------------------------------------------------- -------------------------EMQENVKKCKNFLATLIKLASHNSP SPDTSKNVKALVQDLLDAKIEPEEFTTRLQAELKSSPQPYLIPFLKKSLP ALRQTLLNSQQSLMTxx--------------------xxxxx-------- ---xx--------------------------------------------- ---xxxxx---------xxxx----------------------------- -------AAIRPRLPxxxxxxxxxxxxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------V--------RGPTTIISKSPVNLAAQ--ANQK-KL SDPGGGTFRDDDDINDVASMAGVNLNEENARILATSSELVGTKIRSCKDE SFLPTGLLLRRILDTAKKFGVTEVPPEVVNLISHATQSRLRTLLEKVSVI AQHRTDGGKDEER--HEQTSDVRSQLRFFEQLERLEKQRKDEQEREILLK AAK---------------SRARQEDPEQARLKQKAKEMQQQELAQMRQRD ANLTALAAIGPRKKRKLDSPGG--x-GTEV-------------------- --xxx----xxx-------------------------------------- -------------------------------------------------x xS-xAASSRQQPRQRITRVNLRDLIFCMEHDRPTARSLILYKALLK >ENSHHUP00000047753 -------------------------------------------------- -------MAGASDPLEDMLF--NEVDEKAVSDLVGSLESQLVSQKTSP-- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxx-xxxxx-------xx------------- ----xxQxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---QTYG AA------x---xx------------------------------------ -------------------------------------------------- ------------------------xx------------------------ -------------------------------------------------- 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AFLPPGLLHRRIMETAKRFGVTEVPAEAVNYISHATQARLRSMLEKVSTI AQHRTDGGKDEEW--YEPSTDVRAQLRFFEQLDRMEKQRKDEQEREVLLK AAK---------------SRARQEDPEQARLKAKAKEMQQAEQAQIRQRE ANLTALAAIGPRKKRKMDSPGSSTS-GTEV-------------------- --xxx----xxx-------------------------------------- -------------------------------------------------x xx-TAASSRQQLRQRITRVNLRDFIFCLEQERATSRSLLLYKALLK >ENSELUP00000038240 -------------------------------------------------- -------MAGASDPLEDMLF--NEVDEKAVSDLVGSLESQLVSQKTSP-- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxx-xxxxx-------xx------------- ----xxQxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---QTHG SA------xxxxxx------------------------------------ -------------------------------------------------- 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