>ENSMMOP00000022784 ------------------------------------------------------------ --------------------------------MAAGSYSLADVFFNTEVDEKVVSDLVGS VESELSAAGRANTTAGGQSAANHVGSCAVG----SNS----------------------- --------------------SVQSSKMGLSQQELAKAGTVAAHS---------------- -------------------------------------------------G---------- ------------------IDARRGLINCT------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------HASSMDGA------------------------------------ ----------------------------------------------------AGTT---- ------------------------------------------------------------ ------------------------------------------SAAGPS-VTAAQTQSKTG ------------------------------------------------------------ -------------------------------------------------TASGAVTVASD AASGVGKTG--------------------------------------------------- -------TAGAQTLNGSTVLVNCHVPGSAAV------DTRGSNSHVNSH----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------VNNGPV---------SVSKDSAAGLSA--------------TP-------GAI IRTPP------------------------------------------------------- TSAQNT-----------------VISSQQ------------------------------- ----------------------ST-KSVPTVTLVR-APMQTPS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------STSQS--SPATVLTPPAVSVSSTTGSLLNKPDATKAVI---- -------------QTGG------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------HVVAS --------TTRSPS---------------------------------------------- --VLQN--LRTSATSTV----GTA--PA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------AGVRTVTQ------- -------------------------------------QV-LAPRLSQP-------NI--Q NIQLPP---GMVLVRSESGQLLMIHQQTLAQM------------------------QAQS QSQ----SAMTPRPAAPTST-PPV--QITTLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGASL LTRT-VTP--TTIIKQGSTVHTTVT-ATTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------VTP------------------------------------AFTAIHISAVNLIC AHQKILNFVGIFL-------Q--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTANVKELVKKLLEAKIEPEDFTSNLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QTSTPT-----------AAAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSAA-------------------- ------------------------------------------------------------ ----------------------------------ATMATSTASTKTTVISLTQ------- -----------PPHSKPGL----------------------------------------- ------------------------------------------------------------ --------------------------------------------------------YMTN DLNFTFLSLNFYVCKAISVWTQGKVENISLLMSVSSVSS--------------------- -------V---------------------------------------------------- ------------S----------------------------------------------- ---------------------------------------P-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESDRILATNSELVGTVTRSCKDETFLSTSLLGRRALEIGKKFGVSELGTDVINYI SHATQQRLQNLLEKVSQVAQLKNQSFK-EDERYEQVGDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------VRGAS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSGPSQPGGSSG---------------AGCRQFMRQRITR VNLRDLLFCLETERGTSHSQLLYRGFLK-- >ENSPREP00000011437 ------------------------------------------------------------ --------------------------------MAAGSDLLADVFSNRAVDKKVVSEVV-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------RAFNTL------ --------LRG----AICANLTSGIQLA----KNHFLI---------VRGS--------- ------------------------------------------------------------ ----------------HGRSMEGT------------------------------------ ----------------------------------------------------AGIT---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------SAAEPI TTAAQSHFGSLTTSGAVTGASGATAGADKQQATGAPA----------------------- ------------------------------------------------------------ -------------LDGNGAVMNCHIPGS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GQSDSSQTAAVNGPASSSPGFIIRTS---------------- LSAQNPSTSS-------------GSSSQP------------------------------- ----------------------AE-KTVPTVALVRPPPMQTSA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NESQSTECPNTVV----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SGSGSVSCKTEPTKSITQAGAQVLPS GVL---TATMRNPT---------------------------------------------- --VLQN--MRTTLSSTI----SAA--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------AGIRTIAP------- -------------------------------------QV-LAPRLTQPQQNA-T-SI--Q NIQIP---AGMVLVRSESGQLLMIHQQTLAQM------------------------QAQA QSQ----SATTPRPAAPTST-PPV--QVTSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------TPGGPL LARS-VTP--TTIIKQGSPVQTTVA-TTTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------VPQ-------------S------VC-------------- -------ILAYLFVV---------------VTETLENVKKCGNFLSTLIKLASNGKQSSE TTATVKELVKNLLEGKMEPEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDPEAFI QQSLLP------------QSSGQS-----------AAATSPAL------------GA--- --------------------------------------VVL------------------- ---------------------------------RPSLSPA-------------------- ------------------------------------------------------------ ----------------------------------VSSATGSTTTKATVITLSQ------- -----------KANSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------VIKNILGS---------------------------IYSNHFTSCCDLSCFSKL CHKVNFCPNLYIL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GSVVKQNV APGTRG-VQL-------------------------------------------------- ------------------------------------------------------------ -----------------------------LNQASLV-------------------DAQR- ----------------------------------------------NRLREAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEENARIMASSSELVGIVTRSCKDEAFLSISPLTRIVLQIGKKFGVSELGTDVINYI SHATQQRLQNLLENASQVAQLKNLNFK-EEERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQLELAQI RQREANLTALAAIGPRKKRR-TDSP--------------LSGAS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGLGSTQPGGSSG---------------QGSRQFMRHRITR VNLRDLLLCLENDRDSSHSQLLYKGLLK-- >ENSGAFP00000020284 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MVLVRSESGQLLMIHQQTLAQM------------------------QAQA QSQ----SATTPRPAAPTST-PPV--QVTSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------TPGGPL LARS-VTP--TTIIKQGSPVQTTIA-TTTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------VPQ-------------S------VC-------------- -------ILRYLIVV---------------VTETLENVKKCGNFLSTLIKLASSGKQSSE TTATVKELVRNLLEGKIEPEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDPEAFI QQSLLP------------QPSGQP-----------AAATSPAL------------GA--- --------------------------------------VVL------------------- ---------------------------------RPSLSPA-------------------- ------------------------------------------------------------ ----------------------------------VSAATGSTTTKATVITLSQ------- -----------KANSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------VIKLLL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----G-VQL-------------------------------------------------- ------------------------------------------------------------ -----------------------------LNQASLI-------------------DAQR- ----------------------------------------------NKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEENARIMASSSELVGIVTRSCKDEAFLSIPSLTRIVLQIGKKFGVSELGTDVITYI SHATQQRLQNLLENASHVAQLKNLNFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQLELAQI RQREANLTALAAIGPRKKRR-TDSP--------------LSGASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGLGSSQPGGSSG---------------QGSRQFMRQRITR VNLRDLLLCLENDRDSNHSQLLYKGLLK-- >ENSXMAP00000026305 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MDGT------------------------------------ ----------------------------------------------------AGIT---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------SAAETI PTAAKSHFGSLTTSGAVTGASGATAGGDKQQATGAPA----------------------- ------------------------------------------------------------ -------------LDGNGAVMNCHIPGS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GQSDSSQTAVVNGPASASPGFIIRTN---------------- PSAQNTSTSS-------------GSSSQP------------------------------- ----------------------AE-KTVPTVALVR-PPMQTSA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NETQSTESPNTVL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSGSGSVSCKTEPTKNITQAGAQVLPS GVL---SATMRNPT---------------------------------------------- --VLQN--LRTTLSSTI----SAA--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRSIAP------- -------------------------------------QV-LAPRLTQPQQNA-T-SI--Q NIQIP---AGMVLVRSESGQLLMIHQQTLAQM------------------------QAQA QSQ----SATTPRPAAPPST-PPV--QVTSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------TPGGPL LARS-VTP--TTIIKQGSPVQTTVA-TTTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIILGGNAT STGQA--------------------------------LGTPTTVQ---ATAAVTQRVGPL GV-TGVPVTP-------------------------------------------------- --------------TTIT--A--------------------------------------- --------------------------------ETLENVKKCGNFLSTLIKLASNGKQSSE TTATVKELVRNLLEGKIEPEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDPEAFI QQSLLP------------QPSSQP-----------AAATSPAL------------GA--- --------------------------------------VVL------------------- ---------------------------------RPSLSPA-------------------- ------------------------------------------------------------ ----------------------------------VSAATGSTTTKATVITLSQ------- -----------KANSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------V---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------AQQQ----VR-P-QVTLAQ-- SP-LVTIRG-AAPSRIIVGQPQ-------------------------------------- ----------M-VRHT-------------------------------------------- ----------------------------PQ----------------------GSVVKQNV APGTRG-VQL-------------------------------------------------- ------------------------------------------------------------ -----------------------------LNQASLV-------------------DAQR- ----------------------------------------------NKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEENARIMASSSELVGIVTRSCKDEAFLSISSLTRIVLQIGKKFGVSELGTDVINYI SHATQQRLQNLLESASQVAQLKNLNFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQLELAQI RQREANLTALAAIGPRKKRR-TDSP--------------LS-ASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGLGSSQPGGSSG---------------QGSRQFMRQRITR VNLRDLLLCLENDRDSSHSQLLYKGLLK-- >ENSPLAP00000021753 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MEGT------------------------------------ ----------------------------------------------------AGIT---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------SAAEPI TTAAQSHFDSLATSGAVTGASGATAGADKQQATGAPA----------------------- ------------------------------------------------------------ -------------LDGNGAVMNCHIPGS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GQSDSSQTAPVNGPTSASPGFIIRTS---------------- LSAQNPSTSS-------------GSSSQP------------------------------- ----------------------AE-KIVPTVALVRPPPMQTSA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NESQSTDSPNTVL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSGSGSVSCKTEPTKSITQAGAQVLPS GVL---TATMRNPT---------------------------------------------- --VLQN--MRTTLSSTI----SAA--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRTIAP------- -------------------------------------QV-LAPRLTQPQQNA-T-SI--Q NIQIP---AGMVLVRSESGQLLMIHQQTLAQM------------------------QAQA QSQ----SATTPRPAAPTST-PPV--QVASLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------TPGGPL LARS-VTP--TTIIKQGSPVQTTVA-TTATLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIILGGNAT STGQA--------------------------------LGTPTTVQ---ATAAVTQRVGPL GA-TGVPVTP-------------------------------------------------- --------------TAIT--A--------------------------------------- --------------------------------ETLENVKKCGNFLSTLIKLASNGKQSSE TTATVKELVKNLLEGKMEPEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDPEAFI QQSLLP------------QPSGQP-----------AAATSPAL------------GA--- --------------------------------------VVL------------------- ---------------------------------RPSLSPA-------------------- ------------------------------------------------------------ ----------------------------------VSAATGSTTTKATVITLSQ------- -----------KANSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------V---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------TQQQ---PVR-P-QVTLAQ-- SP-LVTVRG-AAPSRIIVGQPQ-------------------------------------- ----------M-VRHI-------------------------------------------- ----------------------------PQ----------------------GSVVKQNV APGTRG-VQL-------------------------------------------------- ------------------------------------------------------------ -----------------------------LNQASLV-------------------DAQR- ----------------------------------------------NKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVTSMAG VNLSEENARIMASSSELVGIVTRSCKDEAFLSISSLTRIVLQIGKKFGVSELGTDVINYI SHATQQRLQNLLENASQVAQLKNFNFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQLELAQI RQREANLTALAAIGPRKKRR-TDSP--------------LSGASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGLGSSQPGGSSG---------------QGSRQFMRQRITR VNLRDLLLCLENDRDSSHSELLYKGLLK-- >ENSPMEP00000034021 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MEGT------------------------------------ ----------------------------------------------------AGIT---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------SAAEPI TTAAQSHFDSLATSGAVTGASGATAGADKQQATGAPA----------------------- ------------------------------------------------------------ -------------SDGNGAVMNCHIPGS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GQSDSSQTAAVNGPTSASPGFIIRTS---------------- LSAQNPSTSS-------------GSSSQP------------------------------- ----------------------AE-KTVPTVALVRPPPMQTSA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NESQSTDSPNTVL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSGSGSVSCKTEATKSITQAGAQVLPS GVL---TATMRNPT---------------------------------------------- --VLQN--MRTTLSSTI----SAA--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRTIAP------- -------------------------------------QV-LAPRLTQPQQNA-T-SI--Q NIQIP---AGMVLVRSESGQLLMIHQQTLAQM------------------------QAQA QSQ----SATTPRPAAPTST-PPV--QVASLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------TPGGPL LARS-VTP--TTIIKQGSPVQTTVA-TTATLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIILGGNAT STGQA--------------------------------LGTPTTVQ---ATAAVTQRVGPL GA-TGVPVTP-------------------------------------------------- --------------TAIT--A--------------------------------------- --------------------------------ETLENVKKCGNFLSTLIKLASNGKQSSE TTATVKELVKNLLEGKMEPEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDPEAFI QQSLLP------------QPSSQP-----------AAATSPAL------------GA--- --------------------------------------VVL------------------- ---------------------------------RPSLSPA-------------------- ------------------------------------------------------------ ----------------------------------VSAATGSTTTKATVITLSQ------- -----------KANSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------V---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------TQQQ---PVR-P-QVTLAQ-- SP-LVTVRG-AAPSRIIVGQPQ-------------------------------------- ----------M-VRHI-------------------------------------------- ----------------------------PQ----------------------GSVVKQNV APGTRG-VQL-------------------------------------------------- ------------------------------------------------------------ -----------------------------LNQASLV-------------------DAQR- ----------------------------------------------NKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVTSMAG VNLSEENARIMASSSELVGIVTRSCKDEAFLSISSLTRIVLQIGKKFGVSELGTDVINYI SHATQQRLQNLLENASQVAQLKNFHFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQLELAQI RQREANLTALAAIGPRKKRR-TDSP--------------LSGASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGLGSSQPGGSSG---------------QGSRQFMRQRITR VNLRDLLLCLENDRDSSHSQLLYKGLLK-- >ENSPFOP00000010203 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MEGT------------------------------------ ----------------------------------------------------AGIT---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------SAAEPI TTAAQSHFDSLATSGAVTGASGATAGADKQQATGAPA----------------------- ------------------------------------------------------------ -------------SDGNGAVMNCHIPGS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------RQSDSSQTAPVNGPTSASPGFIIRTS---------------- LSAQNPSTSS-------------GSSSQP------------------------------- ----------------------AE-KTVPTVALVRPPPVQTSA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NESQSTDSPNTVL----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSGSGSVSCKTEATKSITQAGAQVLPS GVL---TATMRNPT---------------------------------------------- --VLQN--MRTTLSSTI----SAA--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRTIAP------- -------------------------------------QV-LAPRLTQPQQNA-T-SI--Q NIQIP---AGMVLVRSESGQLLMIHQQTLAQM------------------------QAQA QSQ----SATTPRPAAPTST-PPV--QVASLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------TPGGPL LARS-VTP--TTIIKQGSPVQTTVA-TTATLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIILGGNAT STGQA--------------------------------LGTPTTVQ---ATAAVTQRVGPL GT-TGVPVTP-------------------------------------------------- --------------TAIT--A--------------------------------------- --------------------------------ETLENVKKCGNFLSTLIKLASNGKQSSE TTATVKELVKNLLEGKMEPEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDPEAFI QQSLLP------------QPSSQP-----------AAATSPAL------------GA--- --------------------------------------VVL------------------- ---------------------------------RPSLSPA-------------------- ------------------------------------------------------------ ----------------------------------VSAATGSTTTKATVITLSQ------- -----------KANSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------V---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------TQQQ---PVR-P-QVTLAQ-- SP-LVTVRG-AAPSRIIVGQPQ-------------------------------------- ----------M-VRHI-------------------------------------------- ----------------------------PQ----------------------GSVVKQNV APGTRG-VQL-------------------------------------------------- ------------------------------------------------------------ -----------------------------LNQASLV-------------------DAQR- ----------------------------------------------NKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVTSMAG VNLSEENARIMASSSELVGIVTRSCKDEAFLSISSLTRIVLQIGKKFGVSELGTDVINYI SHATQQRLQNLLENASQVAQLKNFNFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQLELAQI RQREANLTALAAIGPRKKRR-TDSP--------------LSGASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGLGSSQPGGSSG---------------QGSRQFMRQRITR VNLRDLLLCLENDRDSSHSQLLYKGLLK-- >ENSXCOP00000015076 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MVLVRSESGQLLMIHQQTLAQM------------------------QAQA QSQ----SATTPRPAAPPST-PPV--QVTSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------TPGGPL LARS-VTP--TTIIKQGSPVQTTVA-TTTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----VPQSV---------------------------SLGTPTTVQ---ATAAVTQRVGPL GV-TGVPVTP-------------------------------------------------- --------------TTI------------------------------------------- -------------------------------TETLENVKKCGNFLSTLIKLASNGKQSSE TTATVKELVRNLLEGKIEPEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDPEAFI HQSLLS------------QPSSQP-----------AAATSPAL------------GA--- --------------------------------------VVL------------------- ---------------------------------RPSLSPA-------------------- ------------------------------------------------------------ ----------------------------------VSA----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SKLFQIVVSLPSCGFFVQLWDTGNILEFIYSNHFTSCCVLSCFSKR RHKVNFCPNLYIL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GSVVKQNV APGTRG-VQL-------------------------------------------------- ------------------------------------------------------------ -----------------------------LNQASLV-------------------DAQR- ----------------------------------------------NKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEENARIMASSSELVGIVTRSCKDEAFLSISSLTRIVLQIGKKFGVSELGTDVINYI SHATQQRLQNLLENASQVAQLKNLNFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQLELAQI RQREANLTALAAIGPRKKRR-TDSP--------------LS-ASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGLGSSQPGGSSG---------------QGSRQFMRQRITR VNLRDLLLCLENDRDSSHSQLLYQGLLK-- >ENSCVAP00000010278 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------YFAGMVLVRSESGQLLMIHQQTLAQM------------------------QAQA QSQ----SAITPRPVAPSTT-PSV--QVT------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ASQVQTLKQRN---------------------TT---------------------- ------------------------------------------------------------ -------------------------------------------------HNTIVLGGNAS SSGQA--------------------------------LGTSATVQ---ATTVVTQRVAPL G----------------------------------------------------------- ------------------------------------------------------------ --------------------------------ETLENVKKCRNFLSTLIKLASNGKQSSE TTASVKELVKSLLEGRIEPDDFTKQLYKELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QPSTQP-----------AAAASTAL------------GA--- --------------------------------------VVL------------------- ---------------------------------RPPLPP--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T ATVATVNFCPHLSILVSMVKQTVVPGARGVKVINPASPIN----VQNKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESARIMATSSELVGIVTRSCKDEAFLSISSLTRIVLQIGKRFGVSELGTDVISYI SHATQQRLQNLLEKASHVAQQKNINFR-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQLELAQI RQREANLTALAAIGPRKKRK-TDSP--------------LSGASA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------SGSGPTQPGGSNG---------------PGSRQFMRQRITR VNLRDLLLCLENDRETSHSQLLYKGLLK-- >ENSFHEP00000002580 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MDGT------------------------------------ ----------------------------------------------------AGIP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------PAAEPN TAAAQAHLGSAAAGGAVRGASGATAGADKQQAAGAPA----------------------- ------------------------------------------------------------ -------------LDGSGALANCHIPGS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GQPASSPSAAVNGPASASPGFVIRTA---------------- PSAQNTSTSP-------------GSASQP------------------------------- ----------------------SA-NTVPTVALVR-PPMQTSA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NESPSADGP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SPGSVGVSCKTEPTKTITHTGAQVMAS GVLTGTTATMRSPT---------------------------------------------- --VLQN--LRASLPSAV----GAT--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRTIAP------- -------------------------------------QV-LAPRLTQPHQNP-T-SI--Q NIQLPP---GMVLVRSESGQLLMIHQQTLAQM------------------------QAQA QSQ----SAITPRPVAPTGT-PPV--QVTSAQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------TPGAPL LARS-VTP--TTIIKQGSSVQTTVT-TTTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIILGGNAT STGQA--------------------------------LGTSTTVQ---ATAAVTQRVGPL GA-TGVPVAP-------------------------------------------------- --------------IAVT--A--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASNGKQSSE TTASVKELVKNLLEGKMEPDDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDSEAFV QQSLLP------------QPSTQP-----------AATASAAL------------SA--- --------------------------------------VVL------------------- ---------------------------------RPPLPPA-------------------- ------------------------------------------------------------ ----------------------------------VTAAAGTATTKATVITLSQ------- -----------TANSKPRL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------V---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQQGSAVR-P-QVTLAQ-- PS-LVTIRG-AAPSRIIVGQPQ-------------------------------------- ----------M-VRPI-------------------------------------------- ----------------------------PT----------------------GSVVKQTV AAGARG-VQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------FNQASLI-------------------DAQR- ----------------------------------------------NKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESAR-MATSSELVGIVTRSCKDEAFLSISSLTRIVLQIGKRFGVSELGTDVISYI SHATQQRLQNLLEKASQVAQQKNINFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQLELAQM MQREANLTALAAIGPRKKRK-TDSP--------------LSGASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSGPSQPGGSSG---------------PGSRQFMRQRITR VNLRDLLLCLENERETSHSQLFYKGLLK-- >ENSACIP00000003932 ------------------------------------------------------------ --------------------------------MAAGSDLLGDVFFNTEVDEKVVTDLVGS LESELKATGCANTTARVPSAVNHAGNSAVG----SSF----------------------- --------------------NVQGSKMGLSQQELAKAGKIAAHS---------------- ------------------------------------------------------------ -------------------GAQGGVSNST------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------LGSSMDGA------------------------------------ ----------------------------------------------------AGIP---- ------------------------------------------------------------ ------------------------------------------SAAGPS-MTAAQSQSKSD ------------------------------------------------------------ -------------------------------------------------VASGVVTVTLD ATAGADKPG--------------------------------------------------- -------ATGAQTLNGSAVVMNCHITAG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GPTDS--NNS QSAAVALLKNGPV---------SVSKGSVAGLSG--------------TP-------STI IRAT-------------------------------------------------------- LDAQNAVISS-------------VISSQP------------------------------- ----------------------SV-KTVPTVTLVR-PPMQTPV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NPSQSTGSATTVLSSPSVSVSSTTGSPGSKTDCSKTIM---- -------------PTGA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------HVVTS AVATGTAA--RSPT---------------------------------------------- --VLQN--LRTSVPSTV----AAT--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRAIAP------- -------------------------------------QV-LAPRLTQPQQNA-P-NI--Q NIQLPP---GMVLVRSESGQLLMIHQQALAQM------------------------QAQS QSQ----SAMTPRPPAPTST-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGASL LARP-VTP--TTIIKQCSTVQTTVT-ATTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETLENVKKCRNFLSTLIKLA-SGKQSSE TTANVKELVKNLLEAKIEPEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLL----------------PQP-----------AAAVSTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTT-------------------- ------------------------------------------------------------ ----------------------------------VTTTTSPATTKTTVISLTQ------- -----------TPHSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------V---------------------------------------------------- ------------IFFFFFSATGNYYLYLSTLMGMHIEVETSVYMPICTSLKLELVSVPL- -----------CDFLVPAVKQTLAPVTKGVQVLGQASLI--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AAQK- ----------------------------------------------NKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGMVTRSCKDETFLSTSSLTRIVLEIGKKFSVSELGTDVINYI SHATQQRLQDLLGKVSQVAQQKNMTFK-EDEHYEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRR-MDSP--------------VRGAIAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------RSGSCPSQTGGSSG---------------TGSRQFMRQRITR VNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSONIP00000021592 ------------------------------------------------------------ --------------------------------MAAGSDLLGDVFLSTEVDEKVVSDLVGS LESELTETRCDNTTARAPSAENHGGNSAVG----SSL----------------------- --------------------NVQGSKMGLSQQELAKAGKIAAHSGV-------------- ----------------------------------S-----------AAAG---------- ------------------TGAQGGVSNST------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------LGSSMDGA------------------------------------ ----------------------------------------------------AGIT---- ------------------------------------------------------------ ------------------------------------------STAGPS-VTATQSQSKSD ------------------------------------------------------------ -------------------------------------------------AASGVVTVTLD ATAGAGKPG--------------------------------------------------- -------GTGAQTLNGSAVVMNCQITAG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GPADS--NNS QPGAVTLLNNGPV---------SVSKPSAAGLPG--------------TP-------STI IRAT-------------------------------------------------------- LNAQNVVTSS-------------VISSQP------------------------------- ----------------------SV-KTVPTVTLVR-PPMQTSM----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NPSPSTGSPTTVLTSPSVSVTSTTGSPASKTDCPKAIM---- -------------PTGA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------HVVAS VVATGTTATVRSPT---------------------------------------------- --VLQG--LRTSVPSTV----AAT--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRTIVP------- -------------------------------------QV-LAPRLAQPQQNA-P-NI--Q NIQLPPG-TGMVLVRSESGQLLMIPQQALAQM------------------------QAQS QSQ----SAMTPRPPAPTST-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGAPL LARP-VTP--TTIIKQCSTVQTTVT-ATTALQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIMLGGVAT TAGQP--------------------------------LGTATMVQPGSASTAVAQRVGPV GA-TATPVTP-------------------------------------------------- --------------TPVT--A--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTANVKELVKNLLEAKIEPEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QLSPQP-----------TAAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTA-------------------- ------------------------------------------------------------ ----------------------------------ITTTTSPATTKTTVISLTQ------- -----------TPHSKPGL----------------------------------------- ------------------------------------------------------------ -------------------------------------------------------SF--- --------------------------------------SEC------------------- -----AQI---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GTIVR-P-PVTLAQ-- SA-VVTLRG-QTHSRIIVSQPQ-------------------------------------- ----------V-IKQL-------------------------------------------- ----------------------------QT----------------------IPAVKQTL APAPKG-IQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------FSQPSFG-------------------TAQK- ----------------------------------------------NKLKE--GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGMVTRSCKDETFLSTSLLTRIVLEIGKKFSVSELGTDVINYI SHATQQRLQDVLEKVSQVAQQKNLTFK-EDERYEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------GRGANAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSCPSQTGGSGG---------------TGSRQFMRQRITR VNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSPNYP00000028810 ------------------------------------------------------------ --------------------------------MAAGSDLLGDVFLSTEVDEKVVSDLDGS LESELTETRRDNTTARAPSAENHGGNSALG----SSL----------------------- --------------------NVQG------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ S--------------------------------------KM-----------GLS----- ------------------------------------QQ-----ELA--KAASGVVMVTLD ATAGAGRPG--------------------------------------------------- -------ATDAQTLNGGAVVMNCQITAG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GPADS--NNS QPGAVTLLNNGPV---------SVSKPSAAGLPG--------------TP-------STI IR---------------------------------------------------------- ----------------------------P------------------------------- ----------------------SV-KTVPTITLVR-PPMQTSM----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NPSPSTGSPTTVLTSPSVSVTSTTGSPASKTDCPKVIL---- -------------PTGA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------HVVAS VVATGTTATVRSPT---------------------------------------------- --VLQG--LRTSVPSTV----AAT---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRTIVP------- -------------------------------------QV-LAPRLAQPQQNA-P-NI--Q NIQLPP---GMVLVRSESGQLLMIPQQALAQM------------------------QAQS QSQ----SAMTPRPPAPTST-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGAPL LARP-VTP--TTIIKQCSTVQTTVT-ATTALQRPPVLENICVCL---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTANVKELVKNLLEAKIEPEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QLSPQP-----------AAAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTT-------------------- ------------------------------------------------------------ ----------------------------------ITTTTSPATTKTTVISLTQ------- -----------TPHSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------V---------------------------------------------------- ------------M----------------------------------------------- -----------------------------------------QQ-GTIVR-P-PVTLAQ-- SA-VVTLRG-QTHSRIIVGQPQ-------------------------------------- ----------V-IKQL-------------------------------------------- ----------------------------QT------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------K-- ------------------------------------------------------------ ------------------------------------------------------------ NCFCRF------------------------------------------------------ --------------SRD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGMVTRSCKDETFLSTSLLTRIVLDIGKKFSVSELGTDVINYI SHATQQRLQDILEKVSHVAQQKNLTFK-EDEQYEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------GRGANAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSCPSQTGGSGG---------------TGSRQFMRQRITR VNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSNBRP00000029402 ------------------------------------------------------------ --------------------------------MAAGSDLLGDVFLSTEVDEKVVSDLVGS LESELTEARRDNTTARAPSAENHGGNSAVG----SSL----------------------- --------------------NVQG------------------------------------ ------------------------------------------------------------ ------------------TGAQGGVNNST------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------LGSSMDGA------------------------------------ ----------------------------------------------------AGIT---- ------------------------------------------------------------ ------------------------------------------STAGPS-VTATQSQSKSD ------------------------------------------------------------ -------------------------------------------------AASGVVMVTLD ATAGAGRPG--------------------------------------------------- -------ATDAQTLNGNAVVMNCQITAG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GPADS--NNS QPGAVTLLNNGPV---------SVSKPSAAGLPG--------------AP-------STI IRAT-------------------------------------------------------- LNAQNVVTSS-------------VISSQP------------------------------- ----------------------SV-KTVPTVTLVR-PPMQTSM----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NPSPSTGSPTTVLMSPSVSVTSTTGSPASKTDCPKVIL---- -------------PTGA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------HVVAS VVATGTTATVRSPT---------------------------------------------- --VLQG--LRTSVPSTV----AAT--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRTIVP------- -------------------------------------QV-LAPRLAQPQQNA-P-NI--Q NIQLPP---GMVLVRSESGQLLMIPQQALAQM------------------------QAQS QSQ----SAMTPRPPAPTST-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGAPL LARP-VTP--TTIIKQCSTVQTTVT-ATTALQRPPVLQKIFVCL---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTANVKELVKNLLEAKIEPEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QLSPQP-----------AAAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTT-------------------- ------------------------------------------------------------ ----------------------------------ITTTTSPATTKTTVISLTQ------- -----------TPHSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------V---------------------------------------------------- ------------MF---------------------------------------------- --------------------------------------FLLLP-GTIVR-P-PVTLAQ-- SA-VVTLRG-QTHSRIIVGQPQ-------------------------------------- ----------V-IKQL-------------------------------------------- ----------------------------QT------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------K-- ------------------------------------------------------------ ------------------------------------------------------------ NCFCLF------------------------------------------------------ --------------SRD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGMVTRSCKDETFLSTSLLTRIALDIGKKFSVSELGTDVINYI SHATQQRLQDILEKVSHAAQQKNLTFK-EDEQYEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------GRGANAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSCPSQTGGSGG---------------TGSRQFMRQRITR VNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSHBUP00000010741 M----------------------------------------------------------- ----------------------RLTNERSWEKMAAGSDLLGDVFLSTEVDEKVVSDLDGS LESELTETRRDNTTARAPSAENHGGNSALG----SSL----------------------- --------------------NVQGSKMGLSQQELAKAG---------------------- ------------------------------------------------------------ ------------------TGAQGGVSNST------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------LGSSMDGA------------------------------------ ----------------------------------------------------AGIT---- ------------------------------------------------------------ ------------------------------------------STAGPS-VTATQSQSKSD ------------------------------------------------------------ -------------------------------------------------AASGVVMVTLD ATAGAGRPG--------------------------------------------------- -------ATDAQTLNGGAVVMNCQITAG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GPADS--NNS QPGAVTLFNNGPV---------SVSKPSAAGLPG--------------TP-------STI IRAT-------------------------------------------------------- LNAQNVVTSS-------------VISSQP------------------------------- ----------------------SV-KTVPTITLVR-PPMQTSM----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NPSQSTGSPTTVLTSPSVSVTSTTGSPASKTDCPKVIL---- -------------PTGA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------HVVAS VVATGTTATVRSPT---------------------------------------------- --VLQG--LRTSVPSTV----AAT--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRTIVP------- -------------------------------------QV-LAPRLAQPQQNA-P-NI--Q NIQLPP---GMVLVRSESGQLLMIPQQALAQM------------------------QAQS QSQ----SAMTPRPPAPTST-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGAPL LARP-VTP--TTIIKQCSTVQTTVT-ATTALQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIMLGGVAT TAGQP--------------------------------LGTATTVQPGSASTAVAQRVGPV GA-TATPVTP-------------------------------------------------- --------------TPVT--A--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTANVKELVKNLLEAKIEPEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QLSPQP-----------AAAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTT-------------------- ------------------------------------------------------------ ----------------------------------ITTTTSPATTKTTVISLTQ------- -----------TPHSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------I---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GTIVR-P-PVTLAQ-- SA-VVTLRG-QAHSRIIVGQPQ-------------------------------------- ----------V-IKQL-------------------------------------------- ----------------------------QT----------------------IPAVKQTL APAPKG-IQA-------------------------------------------------- ------------------------------------------------------------ -----------------------------FSQPSFG-------------------AAQK- ----------------------------------------------NKLKE-GGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGMVTRSCKDETFLSTSLLTRIVLDIGKKFSVSELGTDVINYI SHATQQRLQDILEKVSHVAQQKNLTFK-EDEQYEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------GRGANAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSCPSQTGGSGG---------------TGSRQFMRQRITR VNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSMZEP00005034783 ------------------------------------------------------------ --------------------------------MAAGSDLLGDVFLSTEVDEKVVSDLDGS LESELTETRRDNTTARAPSAENHGGNSALG----SSL----------------------- --------------------NVQGSKMGLSQQ---------------------------- ----------------------------------DCSTLPLFSCVSAAAG---------- ------------------IGAQGGVSNST------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------LGSSMDGA------------------------------------ ----------------------------------------------------AGIT---- ------------------------------------------------------------ ------------------------------------------STAGPS-VTATQSQSKSD ------------------------------------------------------------ -------------------------------------------------AASGVVMVTLD ATAGAGRPG--------------------------------------------------- -------ATDAQTLNGGAVVMNCQITAG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GPADS--NNS QPGAVTLLNNGP-----------VSKPSAAGLPG--------------TP-------STI IRAT-------------------------------------------------------- LNAQNVVTSS-------------VISSQP------------------------------- ----------------------SV-KTVPTITLVR-PPMQTFM----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NPSPSTGSPTTVLTSPSVSVTSTTGSPASKTDCPKVIL---- -------------PTGA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------HVVAS VVATGT--TVRSPT---------------------------------------------- --VLQG--LRTSVPSTV----AAT---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRTIVP------- -------------------------------------QV-LAPRLAQPQQNA-P-NI--Q NIQLPP---GMVLVRSESGQLLMIPQQALAQM------------------------QAQS QSQ----SAMTPRPPAPTST-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGAPL LARP-VTP--TTIIKQCSTVQTTVT-ATTALQRPPVLENICVCL---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTANVKELVKNLLEAKIEPEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QLSPQP-----------AAAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTT-------------------- ------------------------------------------------------------ ----------------------------------ITTTTSPATTKTTVISLTQ------- -----------TPHSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------V---------------------------------------------------- ------------M----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------D-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGMVTRSCKDETFLSTSLLTRIVLDIGKKFSVSELGTDVINYI SHATQQRLQDILEKVSHVAQQKNLTFK-EDEQYEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------GRGANAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSCPSQTGGSGG---------------TGSRQFMRQRITR VNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSAPOP00000007877 ------------------------------------------------------------ --------------------------------MAAGSDLLDDVFFNTEVDEKVVSALVGS LECELTAAGQCNTTARVQSAANHVGNSAVG----SNF----------------------- --------------------SVQGNKMGLSQQELAKSC---------------------- ------------------------------------STPHLFSCVSAAVW---------- ------------------TGVQCGVSNSA------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------HGSSMDGA------------------------------------ ----------------------------------------------------AGIT---- ------------------------------------------------------------ ------------------------------------------SAAAPS-VTAAQSPSKPA ------------------------------------------------------------ -------------------------------------------------AADGVVMVVPD ATSAVGKPG--------------------------------------------------- -------VTGVQTLNGSAVVMNCHIP------R--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VGPADS--NSS QP-AVTLVNNGPV---------SVSKGGAAVLSA--------------TP-------STI IRTT-------------------------------------------------------- LSAQNAVTSS-------------VISSQP------------------------------- ----------------------SV-KTVPTVTLVR-PPMQSPT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NTSHSAGNPSTVLTTPAVSVTSTAG----------------- ------------------------------------------------------------ --------------------------------------------A--------------- ------------------------------------------------------------ -------------------------------------------------------HVVVS AVATGTTATMRSPT---------------------------------------------- --VLQN--LRTSVPSTI----AAS--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------AGIRAIAP------- -------------------------------------QV-LAPRLTQPQQNA-T-NI--Q NIQLPA---GMVLVRSESGQLLMIHQQTLAQM------------------------QAQS QSQ----SAMTSRPAAPTST-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGASL LARP-VTP--TTIIKQGSTVQTTVT-ATTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------VTPPYFPLGYLFP---------------------------------------- -------------ACKITKSQ--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTANVKELVKNLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI KESLLP------------QPSTQP-----------AAAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTA-------------------- ------------------------------------------------------------ ----------------------------------ITTATSTATTKTTVISLTQ------- -----------TPHSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------I---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GTVVR-P-QVTLAQ-- SP-MVTLRG-QTHSRIIVGQPQ-------------------------------------- ----------V-VKQL-------------------------------------------- ----------------------------QT----------------------VPAVKQTL APGAKT-VQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------LSHASLT-------------------AAQK- ----------------------------------------------NKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGMVTRSCKDEAFLSTSLLTRMALEIGKKFGVSELGTDVINYI SHATQQRLQNLLEKVSQVAQQRNVTFK-EDNRSEQVSDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------LRGAS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSGPSQPGGSGG---------------TGSRQFMRQRITR VNLRDLLFCLENEKGTSHSHLLYKGFLK-- >ENSAOCP00000003356 ------------------------------------------------------------ --------------------------------MAAGSDLLDDVFFNTEVDEKVVSALVGS LEWELTAAGHCNTTARVHSAANHVGNSAVG----SNF----------------------- --------------------SVQGNKMGLSQQELAK------------------------ ------------------------------------------------------------ ----------------------------ADSV--------------GNS----------- ------------------------------------------------EGS--------- ------------------------------------------------------------ ----------------HGSSMDRA------------------------------------ ----------------------------------------------------AGIT---- ------------------------------------------------------------ ------------------------------------------SAAAPS-VTAAQSPSKPG ------------------------------------------------------------ -------------------------------------------------AAGGVVMVVPD ATSAVGKPG--------------------------------------------------- -------VTGVQTLNGSAVVMSCHIP------R--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VGPADS--NSS QP-AVTLVNNGPV---------SVSKGGATVLSA--------------TP-------STI IRTT-------------------------------------------------------- LSAQNAVTSS-------------VISSQP------------------------------- ----------------------SA-KTVPTVTLVR-PPMQSPT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NTSHSAGNPSTVLTTPAVSVTSTAG----------------- ------------------------------------------------------------ --------------------------------------------A--------------- ------------------------------------------------------------ -------------------------------------------------------HVVVS AVATGTTATMRSPT---------------------------------------------- --VLQN--LRTSVPSTI----AAS--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRAIAP------- -------------------------------------QV-LAPRLTQPQQNA-T-NI--Q NIQLPA---GMVLVRSESGQLLMIHQQTLAQM------------------------QAQS QSQ----SAMASRPAAPTST-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGASL LARP-VTP--TTIIKQGSTVQTTVT-ATTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------VTPPYIPLGYLFP----------------------NVNNA----------VVC ------------L-------Q--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTANVKELVKNLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI KESLLA------------QPSTQP-----------AAAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTA-------------------- ------------------------------------------------------------ ----------------------------------ITTATSTATTKTTVISLTQ------- -----------TPHSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------I---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GTMVR-P-QVTLAQ-- SP-MVTLRG-QTHSRIIVGQPQ-------------------------------------- ----------V-VKQL-------------------------------------------- ----------------------------QTG--------------------VFPAVKQTL APGAKT-VQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------LSQASLT-------------------AAQK- ----------------------------------------------NKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGIVTRSCKDETFLSTSSLTRMALEIGKKFGVSELGTDVINYI SHATQQRLQNLLEKVSQVAQQRNVTFK-EDNRSEQVSDVRTQLKFFEELDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------LRGAS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSGPSQPGGSGG---------------TGSRQFMRQRITR VNLRDLLFCLENEKGTSHSHLLYKGFLK-- >ENSAPEP00000019291 ------------------------------------------------------------ --------------------------------MAAGSDLLDDVFFNTEVDEKVVSALVGS LEWELTAAGHCNTTARVHSAANHVGNSAVG----SNF----------------------- --------------------SVQGNKMGLSQQELAK------------------------ ------------------------------------------------------------ ----------------------------ADSV--------------GNS----------- ------------------------------------------------EGS--------- ------------------------------------------------------------ ----------------HGSSMDGA------------------------------------ ----------------------------------------------------AGIT---- ------------------------------------------------------------ ------------------------------------------SAAAPS-VTAAQSPSKPG ------------------------------------------------------------ -------------------------------------------------AAGGVVMVVPD ATSAVGKPG--------------------------------------------------- -------VTGVQTLNGSAVVMSCHIP------R--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VGPADS--NSS QP-AVTLVNNGPV---------SVSKGGATVLSA--------------TP-------STI IRTT-------------------------------------------------------- LSAQNAVTSS-------------VISSQP------------------------------- ----------------------SA-KTVPTVTLVR-PPMQSPT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NTSHSAGNPSTVLTTPAVSVTSTAG----------------- ------------------------------------------------------------ --------------------------------------------A--------------- ------------------------------------------------------------ -------------------------------------------------------HVVVS AVATGTTATMRSPT---------------------------------------------- --VLQN--LRTSVPSTI----AAS--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRAIAP------- -------------------------------------QV-LTPRLTQPQQNA-T-NI--Q NIQLPA---GMVLVRSESGQLLMIHQQTLAQM------------------------QAQS QSQ----SAMASRPAAPTST-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGASL LARP-VTP--TTIIKQGSTVQTTVT-ATTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------VTPPYIPLGYLFP----------------------NVNNA----------VVC ------------L-------Q--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTANVKELVKNLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI KESLLA------------QPSTQP-----------AAAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTA-------------------- ------------------------------------------------------------ ----------------------------------ITTATSTATTKTTVISLTQ------- -----------TPHSKPGLVILLLLG---------------------------------- ------------------------------------------------------------ -----------------------------------------------------INT---- ------------------------------------------------------------ ------S----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------VKQTL APGAKT-VQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------LSQASLT-------------------AAQK- ----------------------------------------------NKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGIVTRSCKDETFLSTSSLTRMALEIGKKFGVSELGTDVINYI SHATQQRLQNLLEKVSQVAQQRNVTFK-EDNRSEQVSNVRTQLKFFEELDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------LRGAS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSGPSQPGGSGG---------------TGSRQFMRQRITR VNLRDLLFCLENEKGTSHSHLLYKGFLK-- >ENSSPAP00000024900 ------------------------------------------------------------ --------------------------------LS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MVLVRSESGQLLMIHQQTLAQM------------------------QAQS QSQ----STMASRPAAPTNT-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGASL LARP-VTP--TTIIKQGSTVQTTVT-ATTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------VTPPHITLGYLFPG--------------AQNYQVPN----------------- --------------------A--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTANVKELVKNLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI KDSLLP------------QPSTQP-----------AAAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTA-------------------- ------------------------------------------------------------ ----------------------------------ITTATSTATTKTTVISLTQ------- -----------TPHSKPGLVIFLLLGNQYLYPNA-------------------------- ------------------------------------------------------------ ------------------------------------VIGHVHGSGTVKCELTSI------ ------------------------------------------------------------ -------I---------------------------------------------------- ------------V----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PAVKQTL VQGAKA-VQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------LSQASLT-------------------AAQK- ----------------------------------------------NKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGMVTRSCKDETFLSTSSLTRMALEIGKKFGVSELGTDVINFI SHATQQRLQNLLEKVSQVAQQKNITFK-EDDRCEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------LRGASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSGPSQPGGSGG---------------TGSRQFMRQRITR VNLRDLLFCLENEKGTSRSHLLYKGFLK-- >ENSLCRP00005003573 ------------------------------------------------------------ --------------------------------MAAGSDLLDDVFFNTELDEKVVSDIVGS LESELSGSDRVNTAAGVQSAGNYAGKSVVG----SNS----------------------- --------------------NVQGSKMGLSQQELAKA----------------------- -------------------------------------------------G---------- ------------------TGVQGGVINSA------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------HGSSMDGA------------------------------------ ----------------------------------------------------AGTTPVVA AAAAAAAGQSMTAAQSQPKPVV-------------------------------------A SGVVTVMSDATAGV-----------------------GKAVTS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GVQTLNGSTVVMNCHITAGASA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DSGGNNS QP-AVTLVNNGPV---------SVSKGSAAVLSA--------------TP-------STI IRT--------------------------------------------------------- -----------------------------C------------STSSA------------- ----------------HNAVISSV-KSVPTVTLVR-PPMQTPT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------IIT-----S-------QS-----GGNP----------------- --------------------------------------------TTVLTSAAVSV----- ---------GS----------------------------------TA------------- ---------------------------ASLVNKT-------------------GGHVVAS TVA--TTATVRSPT---------------------------------------------- --VLQN--LRTSVPSTI----ATT--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------AGIRAIAP------- -------------------------------------QV-LAPRLTQPQQ-----NI--Q NIQLPP---GMVLVRSESGQLLVIHQQTLAQM------------------------QAQS QSQ----SAMTPRPAAPTST-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGASL LARP-VTP--TTIIKQGSTVQTTVT-ATTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIMVGGTAT TPGQP--------------------------------LGTPTTVQPGSAATAVTQRVGPL GA-TGTPVTP-------------------------------------------------- --------------TAIT--A--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTANVKELVKNLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI HQSLLP------------QTST-P-A--------AAAASSTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTA-------------------- ------------------------------------------------------------ ----------------------------------ATTATSTAATKTTVISLTQ------- -----------TPHSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------I---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GTIVR-P-QVTLAQ-- SH-LVTLRG-QSHSRIVVGQPQ-------------------------------------- ----------V-VKQL-------------------------------------------- ----------------------------QT------------------------AVKPTL APGAKG-VQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------VSQTPLT-------------------AAQK- ----------------------------------------------IKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGAVTRSCKDETFLSTSLLTRRALEIGKKFGVSELGTDVINYV SHATQQRLQNLLEKVSQVALQKNTTFK-EDERFEQADDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------VRGASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSGPSQPGGSSG---------------AGSRQFMRQRITR VNLRDLLFCLENERGTSHSQLLYKGFLK-- >ENSLCAP00010041871 M----------------------------------------------------------- ----------------------RLTSERSWAKMAAGSDLLDDVFFNTEVDEKVVSDLVGS LESELTGAGHVNATARVQAAANHVGNSAVG----SNS----------------------- --------------------NVQGSKMGLSQQELAKA----------------------- -------------------------------------------------G---------- ------------------AGVQGGVINSK------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------HGSSMDGA------------------------------------ ----------------------------------------------------TGTT---- ------------------------------------------------------------ ------------------------------------------SAAGPS-MTAAQSQSNSG ------------------------------------------------------------ -------------------------------------------------TTSRVVTVVSD APSGAGKPG--------------------------------------------------- -------TTAVQTLNGSTVVMNCHIPGGASA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DSSGNNS QP-AVTLVNNGPV---------SVSKGSTAILSA--------------AP-------STI IRTTS------------------------------------------------------- TSAQNAVTSP-------------VISSQP------------------------------- ----------------------SL-KSVPTVTLVR-PPMQTPT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NTSQSGGNPITVLPAPAVSVTSTAGTLVNKFDSTKTIV---- -------------QTGA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------HVVAS TVATGTTATIRSPT---------------------------------------------- --VLQN--LRTSVPSTI----AAT--SP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRAIAP------- -------------------------------------QV-LAPRLTQPQQNA-P-NI--Q NIQLPP---GMVLVRSESGQLLMIHQQTLAQM------------------------QAQS QSQ----SAMTPRPAAPTST-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------PPGASL LARS-VTP--TTIIKQGSTVQTTVA-ATTKLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIMLGGTAT TPGQP--------------------------------LGTPTTVQPGTAATAVTQRVGPL GP-TGSSVTP-------------------------------------------------- --------------TAIS--A--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTASVKELVKNLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QPSTQP-----------AATASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTA-------------------- ------------------------------------------------------------ ----------------------------------ATTAASTAATKTTVISLTQ------- -----------TPHSKSGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------I---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GTMVR-P-QVTLAQ-- SP-MVTLRG-QPHSRIIVGQPQ-------------------------------------- ----------V-VKQL-------------------------------------------- ----------------------------QT----------------------VPAVKQTL APGPKG-VQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------VSQAPLT-------------------AAQK- ----------------------------------------------NKLKEAGGGMF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGTVTRSCKDEAFLSTSSLTRRALEIGKKFGVSELGTDVINYI SHATQQRLQNLLEKVTQVAQQKNGTFK-EDERYEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-IYSP--------------VRGASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SSGSGPSQPGGSSG---------------AGSRQFMRQRITR VNLRDLLFCLENEKGNSHSHLLYKGFLK-- >ENSSDUP00000031668 M----------------------------------------------------------- ----------------------RLKNERSCAKMAAGSDLLDDVFFNTEVDEKVVSDLVGS LESKLIGASHINTKAKIQSAANHVGNSAVG----SNS----------------------- --------------------NVQGSKMGLSQQELAKA----------------------- -------------------------------------------------G---------- ------------------TGVQGGIINST------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------LGSSMDGA------------------------------------ ----------------------------------------------------AGTT---- ------------------------------------------------------------ ------------------------------------------SAAGAS-MTAAQSQSKSG ------------------------------------------------------------ -------------------------------------------------TASGVVTVVSD ATSCAGKAG--------------------------------------------------- -------KTGVQTLNGSSVVMNCHIPGGASA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DSSGSNS QP-AVTFVNNGPI---------SVSKGNTAVLSA--------------AP-------STI IRTTS------------------------------------------------------- ASVHNAVTSP-------------VISSQP------------------------------- ----------------------SV-KSVPTVTLVR-PPMQTPT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NTSQSGGNSATVSTSPAVSVTSTAGPLVNKVDFTKTIM---- -------------QTG-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------VVAS TVATGTTATMRSPT---------------------------------------------- --VLQN--LRTSVPSTI----AAT--TP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRTIAP------- -------------------------------------QV-LAPRLTQPQQNA-P-NI--Q NIQLPP---GMVLVRSESGQLLVIHQQTLAQM------------------------QAQS QSQ----SAMTPRPAAPTST-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGASL LARS-VTP--TTIIKQGPTVQTTVT-AATKLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIMLGGTAT TPGQP--------------------------------LGTPTTVQPGSAATAVTQRVGPL GA-TGTPVTP-------------------------------------------------- --------------TAVT--A--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTASVKELVKNLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QPSTQPAA--------AAAAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTA-------------------- ------------------------------------------------------------ ----------------------------------TTTATSTAVTKTTVISLTQ------- -----------APHSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------I---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GAMVR-P-QVTLAQ-- SP-MVTLRG-QPHSRIIVGQPQ-------------------------------------- ----------V-VKQL-------------------------------------------- ----------------------------QT------------------------AVKQTL APGAKG-VQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------VSQAPLT-------------------AAQK- ----------------------------------------------NKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGTMTRSCKDEAFLSTSSLTRRALEIGKKFGVSELGTDVINFI SHATQHRLQNLLEKVSQVAQQKNLTFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MYSP--------------VRGDSAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSGPSQPGVSGG---------------AGSRQFMRQRITR VNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSSLDP00000014166 M----------------------------------------------------------- ----------------------RLTNERSCAKMAAGSDLLDDVFFNTEVDEKVVSDLVGS LESELIGASHVNTEAKIQSAANHVGNSAVG----SNS----------------------- --------------------NVQGSKMGLSQQELAKA----------------------- -------------------------------------------------G---------- ------------------TGVQGGIINST------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------LGSSMDGA------------------------------------ ----------------------------------------------------AGTT---- ------------------------------------------------------------ ------------------------------------------SAAGAS-MTAAQSQSKSG ------------------------------------------------------------ -------------------------------------------------TTSGVVTVVSD ATSCVGKAG--------------------------------------------------- -------KTGVQTLNGSSVVMNCHIPGGASA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DSSGSNS QP-AVTFVNNGPI---------SVSKGSTAVLSA--------------AP-------STI IRTTS------------------------------------------------------- ASVHNAVTSP-------------VISSQP------------------------------- ----------------------SV-KSVPTVTLVR-PPMQTPT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NTSQSGGNSATVSTSPAVSVTSTAGPLVNKVDFTKTIM---- -------------QTG-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------VVAS TVATGTTATMRSPT---------------------------------------------- --VLQN--LRTSVPSTI----AAT--TP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRTIAP------- -------------------------------------QV-LAPRLTQPQQNA-P-NI--Q NIQLPP---GMVLVRSESGQLLVIHQQTLAQM------------------------QAQS QSQ----SAMTPRPAAPTST-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGASL LARS-VTP--TTIIKQGSTVQTTVT-AATKLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIMLGGTAT TPGQP--------------------------------LGTPTTVQPGSAAAAVTQRVGPL GA-TGTPVTP-------------------------------------------------- --------------TAVT--A--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTASVKELVKNLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QPSTQPAA--------AAAAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTA-------------------- ------------------------------------------------------------ ----------------------------------TTTATSTAATKTTVISLTQ------- -----------APHSKQGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------I---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GAMVR-P-QVTLAQ-- SP-MVTLRG-QPHSRIIVGQPQ-------------------------------------- ----------V-VKQL-------------------------------------------- ----------------------------QT----------------------VSAVKQTL ASGAKG-VQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------VSQAPLT-------------------AAQK- ----------------------------------------------NKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGTMTRSCKDEAFLSTSSLTRRALEIGKKFGVSELGTDVINFI SHATQHRLQNLLEKVSQVAQQKNLTFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MYSP--------------VRGDSAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSGPSQPGVSGG---------------AGSRQFMRQRITR VNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSCGOP00000032594 M----------------------------------------------------------- ----------------------RLTSERSLGKMAAGSDLLDDVFFNTEVDEKVVSDLVGS LESELTGAGRVNTPTRVQSAANHFGNSAVG----SNP----------------------- --------------------NVQGRNMGLSQQELAKA----------------------- -------------------------------------------------G---------- ------------------TGVQGGVINST------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------PGSSMDGS------------------------------------ ----------------------------------------------------AGTT---- ------------------------------------------------------------ ------------------------------------------S----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------GM----------PAT--------QSQSKPGTASGV-------------VTAV LGVGKHETTSVQTLNGSAVMMNCHVTGG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------SSGNNS QP-VVTLVNNGPV---------SAIKGSATVLSA--------------TP-------STI IRTYS------------------------------------------------------- TSAPNA-----------------VISSQP------------------------------- ----------------------SV-KSVPTVTLVR-PPMQTPT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NTSHIGGNTTTVLTAPAVSVTSTAGSLVNKFDSTKTIM---- -------------QTGA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------HVMAS TVA---TPTIRSPT---------------------------------------------- --VLQN--LRTSLPSTI----AVT--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRAIAP------- -------------------------------------QV-LAPRLTQPQQNA-P-NI--Q NIQLPP---GMVLVRSESGQLLVIHQQTLAQM------------------------QAQS QSQ----SAMTPRPAAPTST-PPV--QISSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGASL LARP-VTP--TTIIKHGSTGQTTVT-ATTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIMLGGSAT TPGQP--------------------------------VGTPTT------ATAVTQRV--- ---TGTPVTP-------------------------------------------------- --------------TAIT--A--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSTE TTANVKELVKHLLEAKIEPEGFTSRLYQELSSSPQPYLVPFLKRSLPALRLMTPDADSFI HQSLLP------------LPSPQP-----------AATASTAL------------TE--- --------------------------------------VML------------------- ---------------------------------RPPLSTA-------------------- ------------------------------------------------------------ ----------------------------------TTTATSTAATKTTVISLTQ------- -----------TPHSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------I---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GTMVR-P-QVTLSQ-- SP-MVTLRG-QSHSRIIVGQPQ-------------------------------------- ----------M-IRQL-------------------------------------------- ----------------------------QT------------------------AVKQTF APGAKG-VQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------VSQAPLT-------------------AAQK- ----------------------------------------------NRLRETGGGAF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGMVTRSCKDEAFLSTSLLTRRALEIGKKFGVGDLGADVINCI SHAAQQRLQNLLERVSQVAQQRNTAFK-EDAQCQQVSDVRTQLRFFEQLDQMEKQRKEEL EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------VRAAGAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------CSGSDPSQPGGSSG---------------SGSRQFMRQRITR VNLRDLLFCLENEKGTSHSHLLYKGFLK-- >ENSATEP00000022953 M----------------------------------------------------------- ----------------------RLTNERSWAKMAAGSDLLDDVFFNTEVDEKVVSDIVGS LESELTGAGHVKAPAGLQSAANHVGNSAVC----SKS----------------------- --------------------NVQGSKMGLSQQELAKA----------------------- -------------------------------------------------G---------- ------------------TGVKGGVINSL------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------HALSMDGE------------------------------------ ----------------------------------------------------SGST---- ------------------------------------------------------------ ------------------------------------------SAAGPS-MTAAQSEPKPG ------------------------------------------------------------ -------------------------------------------------TAAGVVPAVSE ATSGAGRPG--------------------------------------------------- -------TTSVQTLNGSTVVVNCHIPGGASAVS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SSSSSSS QS-AVTLVNNGPV----------------------------------------------- ----PATEGGSAVLPPTSG-----------------------TAVRT-----------PL TSAQHTVTSP-------------VISCQP------------------------------- ----------------------SV-KSVPTVTLAR-PPMQTPT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ITSQSGG----------------------------------- -----------------------------------------SPA---------------- --------------TAATP-----PAATVDGKSDSAKPVMQTGNA--------------- ------------------------------------------------------------ -------------------------------------------------------HVVAS VLATGTTAIVRSPT---------------------------------------------- --VMQN--VRTSVPSTL----AAT--PS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRAIAP------- -------------------------------------QV-LAPRVTQPQQSA-P-NI--Q NIQLPP---GMVLVRSESGQLLMIHQQTLAQM------------------------QAQS QSQ----SAMTPRPAVPTST-PSV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTSI LARP-VTP--TTIIKQGSTVQTSVT-PTTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIMLGGSAT TPGQM--------------------------------LGTPTTVQPGSAATAVTQR---- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETVENVKKCKNFLSTLIKLASSGKQSSE TTANVKELVKNLLEGKIEPEDFTSSLYRELNSSPQPYLVPFLNRSLPALRQMTPDSEAFI QQSLLP------------QPSTQP-----------AVAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTA-------------------- ------------------------------------------------------------ ----------------------------------TTVATSTAVTKATVISLTQ------- -----------TPHSKPGV----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------V---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GIMVR-P-QVTLAP-- SP-IVTFRG-QPHSRIIVNQPQ-------------------------------------- ----------V-VKHL-------------------------------------------- ----------------------------QT----------------------VSAVKHTL VPGAKG-VQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------VSQASLT-------------------AAQK- ----------------------------------------------NKMKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATSSELVGTVTRSCKDETFLSTSLLTRRALEIGKKFGVRELGIDVINYL SHATQQRLQNLLEKASQVAQQKNTTFK-EDERYEQVNDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANQTALAAIGPRKKRR-MDSP--------------VRGASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSGPSHPGGSAG---------------AGSRQFMRQRITR VNLRDLLSCLENERGTSHSYLLYKGFLK-- >ENSMALP00000032303 ------------------------------------------------------------ --------------------------------MAAGSDLLDDVFFSTEVDEKVVSDLVGS LESELTAAGHVNTTIGIQSAANHVGNLAAR----SNS----------------------- --------------------NVQSRKMGLSQQDLAKA----------------------- -------------------------------------------------G---------- ------------------TGVQGGVINST------------------------------- -------------------------------------------------GF--------- ------------------------------------------------------------ ----------------HNSSMDEA------------------------------------ ----------------------------------------------------AGTP---- ------------------------------------------------------------ ------------------------------------------STAGPS-MTVAQSQSTPG ------------------------------------------------------------ -------------------------------------------------DV--------D ATSGVGTPG--------------------------------------------------- -------TTGVQTLNGSAVVMNCHIPGVASV----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DSSGNNS QS-AVTLINNGPV---------SVSKGSAAVLST--------------TS-------STI IRTSA------------------------------------------------------- TNAQNTVTST-------------VISCQP------------------------------- ----------------------SV-KSVPTVTLVR-PPMQTPV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------STSQSGGIPTTVLTSPAVNVICTTGSLINKLDSTKTTV---- -------------QSGA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------QVVAS TASTGTTATIRSPT---------------------------------------------- --VLQN--SRTSVPA-L----AAT--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRPIAQ------- -------------------------------------QV-LAPRPTQSQPNA-P-NI--Q NIQLPA---GMVLVRSETGQLLMIHQQTLAQI------------------------QAQS QSQ----SAMTPRPAAPTST-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------TPGASL LARP-VTP--TTIIKQGSTVQSTVT-ATTVLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIMLGGTAT TPGQP--------------------------------LGTPTTVQPGSAATAVTQRAGPL GATTTTPVTP-------------------------------------------------- --------------TPVS--A--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTARVKELVKSLLEAKIEPEDFTSRLYQELNSSPQPCLVPFLKRSLPVLREMTPDSEAFI QQ------------------STPP-----------AAAPSKAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLPTT-------------------- ------------------------------------------------------------ ----------------------------------ATSATSTAVTKTTVINLTQ------- -----------TPHSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------I---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GVMVR-P-QVTLAQ-- TP-TVTLRG-QPHNRIIVSQPQ-------------------------------------- ----------L-VKQL-------------------------------------------- ----------------------------QT----------------------VPAVKQML IPGAKG-IQI-------------------------------------------------- ------------------------------------------------------------ -----------------------------ISQAPLI-------------------AAQK- ----------------------------------------------NKLKETGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARIMATNSEIVGMVTHSCKDETFLSTTSLTQRVLEIGKKFGVSELGTEVISYI SHAAQQRLQNLLEKMSHVAQQKNLTFK-EDELYEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------VRGANAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSASGPSQAGGS-----------------SGSRPFMRQRITR VNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSMAMP00000035928 M----------------------------------------------------------- ----------------------RLTRERSWAKMAAGSDLLDDVFFNTEVDEKVVSALVGS LESELTGTGHVNTTSGNQSAANHVGSSVVC----SNS----------------------- --------------------SVQGGKMGLSQQELAKA----------------------- -------------------------------------------------G---------- ------------------TGVQGGVIGST------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------QGSSMDGA------------------------------------ ----------------------------------------------------AGTT---- ------------------------------------------------------------ ------------------------------------------SAAGPS-MTIAQSESNPG ------------------------------------------------------------ -------------------------------------------------AATGDVTVMSD ATSGVGKPG--------------------------------------------------- -------TTAVQTLNGSSVVINCHVSGGASA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DSGGNSS QP-AVTPVNNGPV---------SASKGSAAVSSAP------------SSA-------STV IQTSA------------------------------------------------------- SSAQNTVTSP-------------VISSQP------------------------------- ----------------------SV-KSVPTVTLVR-PPMQTPI----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------N----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------APQSGCSSSTIVSS AAGNVTSTTGSLVNKPDSTKTITQT--A---------------------------QVALS TAASGTTVTVRSPT---------------------------------------------- --VLQN--LRTSAPSAV----AAT--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRAIAP------- -------------------------------------QV-LAPRLTQPQQNT-P-NI--Q NIQLPP---GMVLVRSESGQLLMIHQQTLAQM------------------------QAQS QSQ----SAMTPRPAVPTST-PPV--QITSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTSL LARP-VTP--TTIIKQGSTVPATVT-ATTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIVLGGTAA TPAQP--------------------------------LGTPTTVQPGSATTAVTQRVGPL GA-TPTPVTP-------------------------------------------------- --------------IAIT--A--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTANVKELVKNLLEAKIEPEDFTSRLYRELSSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QTSTQP-----------AAAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPISTC-------------------- ------------------------------------------------------------ ----------------------------------TTTATSTAMTKTTVISLTQ------- -----------TPHSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------M---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GTVVR-P-QVTLAQ-- SP-MVTFRG-PLHSRIIVGQPQ-------------------------------------- ----------V-VKQL-------------------------------------------- ----------------------------QA----------------------VPSLKQPL VPGAKG-IQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------VSQAALT-------------------TAQ-- ----------------------------------------------NKLKDAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLLEESARILATSS-LVGTVTRSCKDETFLSTSSLTQRALEIGKKFGVSELGTDVISYI SYATQQRLQNLLEKVSQVAQQKNITFK-EDQRYEQLSDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------VRGASAEVRNRRVVLMLNHLK FTNETSKSHNKTFSLSYVCSISPPGLRVRPLPAWRLQWRGLQTLYAT------------- ------------------------------------------------------------ -----------------------------------------------AHHQSQPQGPVVL ------------------------------------------------------------ -----------------PGA---------------------------------------- ------------------------------ >ENSORLP00000014852 M----------------------------------------------------------- ----------------------RFTNERGLAKMAASSDLLGDVFFKTERDEKVKSELIGS LDTESTEESHVNSAGGTQSETNHADSSAIR----SSF----------------------- --------------------NIQGSKMGLSQQELAKA----------------------- -------------------------------------------------G---------- ------------------SGVQRGVSSSA------------------------------- ----------GCLVPR-------------------------------------------- ------------------------------------------------------------ --------------------MDGA------------------------------------ ----------------------------------------------------AGVT---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------PAAE-- -------------------------------AVGNPAQSQPQPA-----TASGVVTAASD AASGLEKPE--------------------------------------------------- ---------GAQSLNGSAAVTNCHI-------AESRADS--------SQPNG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------PAPA---------------------------------------------- -----------------------CKEEA-------------------AAV---------- ------------------------------------------------QP-------STI IRTT-------------------------------------------------------- LSAQNAPSPG-------------VVPAQPG------------ART--------------- --------------------------TVPTVTLVK-PLMQTST----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SSPVLTSSSPGISVSSSSPV TKSDCTKSVILTGGQAAPP-----P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----GATATIRSPG---------------------------------------------- --VWPN--PRTAAPSTI----AAA---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGVRPPAP------- -------------------------------------QV-LAPRLSQPQQNT-T-NI--Q NIQLPP---GMVLIRSESGQLLMIHQQTLAQM------------------------QAQS QSQ----SAMTPRPAAPTST-PPV--Q-TSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------TPGTPL LTRP-VTS--TTIIKQASPVQTTGI-VTTALQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTVMLGVTAS --GQP--------------------------------MGTAAKVQPAA------QRVGPL GA-TGTAVAP-------------------------------------------------- --------------TPVS--A--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLA-SGKQSPQ TSANVKELIKNLLQAKIEPEDFTSRLYKELSSSPQPYLVPFLKRSLPALRQMTPDPDAFI QQSLLP------------LPSTQP-----------VATASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTT-------------------- ------------------------------------------------------------ ----------------------------------VTTATST--TKATVISLTQ------- -----------TPQSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------I---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------SQQQ-GTMVR-P-QVPLAQ-- SP-VVTIRG-QPHSRIIVGQPQ-------------------------------------- ----------V-VKQL-------------------------------------------- ----------------------------TA----------------------VPAVRQTL APGIRG-VQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------LGHASVA-------------------DAHR- ----------------------------------------------NRLKEAGGGAF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESARILATSSELVGMVTRSCKDEAFLSTPSLTRIALEIGKKFGVSELGTDVISYI SHATQQRLQNLLEKVSQVAHHKNVTLK-EDERCEQVSDVRGQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQLELAQI RQREANLAALAAIGPRKKRK-TDSP--------------VKGAGAD-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSSSGPSQPGGSGG---------------AGSRQFTRQRITR VNLRDLLFCLENEKETSHSQLLYKGFLK-- >ENSORLP00020032548 M----------------------------------------------------------- ----------------------RFTNERGLAKMAASSDLLGDVFFKTERDEKVKSELIGS LDTESTEESHVNSAGGTQSETNHADSSAIR----SSF----------------------- --------------------NIQGSKMGLSQQELAKA----------------------- -------------------------------------------------G---------- ------------------SGVQRGVSSSA------------------------------- ----------GCLVPR-------------------------------------------- ------------------------------------------------------------ --------------------MDGA------------------------------------ ----------------------------------------------------AGVT---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------PAAE-- -------------------------------AVGNPAQSQPQPA-----TASGVVTAASD AASGLEKPA--------------------------------------------------- ---------GAQSLNGSAAVTNCHI-------AESRADS--------SQPNG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------PAPA---------------------------------------------- -----------------------CKEEA-------------------AAV---------- ------------------------------------------------QP-------STI IRTT-------------------------------------------------------- LSAQNAPSPG-------------VVPAQPG------------ART--------------- --------------------------TVPTVTLVK-PLMQTST----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SSPVLTSSSPGISVSSSSPV TKSDCTKSVILTGAQAAPP-----P----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----GATATIRSPG---------------------------------------------- --VWPN--PRTAAPSTI----AAA---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGVRPPAP------- -------------------------------------QV-LAPRLSQPQQNT-T-NI--Q NIQLPP---GMVLIRSESGQLLMIHQQTLAQM------------------------QAQS QSQ----SAMTPRPAASTST-PPV--Q-TSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------TPGTPL LTRP-VTS--TTIIKQASPVQTTGI-VTTALQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTVMLGVTAS --GQP--------------------------------MGTAAKVQPAA------QRVGPL G-----AVAP-------------------------------------------------- --------------TPVS--A--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLA-SGKQSPQ TSANVKELIKNLLQAKIEPEDFTSRLYKELSSSPQPYLVPFLKRSLPALRQMTPDPDAFI QQSLLP------------LPSTQP-----------AATASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPMSTT-------------------- ------------------------------------------------------------ ----------------------------------VTTATST--TKATVISLTQ------- -----------TPQSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------I---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------SQQQ-GTMVR-P-QVPLAQ-- SP-VVTIRG-QPHSRIIVGQPQ-------------------------------------- ----------V-VKQL-------------------------------------------- ----------------------------TA----------------------VPAVRQTL APGIRG-VQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------LGHASVA-------------------DAHR- ----------------------------------------------NRLKEAGGGAF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESARILATSSELVGMVTRSCKDEAFLSTPSLTRIALEIGKKFGVSELGTDVISYI SHATQQRLQNLLEKVSQVAHHKNVTLK-EDERCEQVSDVRGQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQLELAQI RQREANLAALAAIGPRKKRK-TDSP--------------VKGAGAD-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSSSGPSQPGGSGG---------------AGSRQFTRQRITR VNLRDLLFCLENEKETSHSQLLYKGFLK-- >ENSLBEP00000010312 ------------------------------------------------------------ --------------------------------MAADSDLLGDVLLDAAADEKV------- ------------------------------------AGEDTVGSAESSVTEAGRVNANSA STQCAENHVSSVAVLSNACANVQRSKMGLSQQEVAK------------------------ ------------------------------------------------------------ ------------------TGAHGGVISST------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------LDSNRDGA------------------------------------ ----------------------------------------------------AGTT---- ------------------------------------------------------------ ------------------------------------------SAAGPS-LTAGQSQSKTG ------------------------------------------------------------ -------------------------------------------------AAAG------- -----------------------------------------GVETVSPDATTGANAL--- -----------QTLNGSAVVTSCHPPGG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GPADS----- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SAQP-----------------PAATLVNNGHAAVL PAAPPTITRTSSPASLHTAVVSSV-KSEPTVTLAR-PPMQTPTT---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------TTNTSRSGGSPGAVLTSPAVSVTSTTGPSVNKLDTSKT------ ------------------------------------------------------------ ------------------------------------------------------VFHASG HKVASTVAAG-------------------------------------------------- ------------------------------------------------------------ --------TMRSST---------------------------------------------- --VLQN--LRTSVPSTITAAAAAA--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------AGIRAIAP------- -------------------------------------QV-LAPRLTQTQQNA-P-NI--Q NIQLPP---GMVLVRSESGQLLMIHQQTLAQM------------------------QAQS QSQ----SAMTPRPAAPTST-PPF--QINSLK---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTSL LPRP-VTP--MTIIKQASPVQTSVT-ATTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTMMLGGSAT TPGQT--------------------------------LVTPSTVQPGSAATAVTQRVGSL AA-TGTPVTP-------------------------------------------------- --------------IAVT--A--------------------------------------- --------------------------------ETLENVKKCRNFLSTLIKLASSGKQSSE TTANVKELVKNLLEAKLEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSEAFI QQSLPP------------QPSSQP-----------TTAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTA-------------------- ------------------------------------------------------------ ----------------------------------ATTTTSAAATKTTVINLTQ------- -----------TTHSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------I---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GTVLR-P-QMTLAQ-- SP-MVTLRG-QPHNRIIVSQPQ-------------------------------------- ----------V-VKQL-------------------------------------------- ----------------------------HA------------------------GVKQTL APGVKGVVQI-------------------------------------------------- ------------------------------------------------------------ -----------------------------VSQSALA-------------------VAQN- ----------------------------------------------HKQKETGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGAVTRSCKDESFLSTSLLTQRALGIGKKFGVSELGSDVINYI SYATQQRLQNLLEKVSQVAQQKNMTFK-EDERYKQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------VRGASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSGPSQPGASSR---------------SGSRQFTRQRITR VNLKDLLFCMENERETSHSHLLYKCFLK-- >ENSBSLP00000036051 ------------------------------------------------------------ --------------------------------MAAGTDLLDDVFLNTEVDEKVVSDVVGS LESELTETGCVNTSTRVQPAANHTGNS--------------------------------- ---------------------------------------------LVRTSNGESIARA-- -----------------------PVSSCVSAAVGT------------------------- ----------------------GGVLNST------------------------------- -------------------------------------------------GS--------- ------------------------------------------------------------ ----------------RDSSMDGA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------TSASKTAAQAESD------- ------------------------------------------------------------ -------PGTVTGVVTDTRNPH-------------------------------------- -------AAAAQTLNGSAAVMSCHIPAGASA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DGGGDSS QS-AVTLVNNGPV---------SESRGS--------------------SPA-----CSTI VRTST-----------------------------------------TGDGSHVKADTSP- ---------------------------QP------------------------------- ----------------------SA-QSVPTVTLVR-PPMQT------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LIS---------- ------------------------------------------------------------ -------------NKSDSTKAVTQTCNAQ----------------------------VAS VVPTGIAPSTKSPA---------------------------------------------- --VLHN--LRTSVPSTL----AAT--PA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------AGIRAAAP------- -------------------------------------PA-LAPRITQPQQ-----NV--Q NIQLPP---GMVLIRSESGQLLMIHQQTLAQM------------------------QAQS QSQ----SAVTPRPAAPTST-PAV--QLTSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------ASGTSI LTRS-VTP--TTIIKQGSTVQTTVT-PTTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETLENVKKCKNFLSTLIKLASSGKQSSE TTANVKKLVKNLLEGKIEPEDFTSSLYRELSSSPQPYLVPFLNRSLPALRQMTPDAEAFI QQSLGP------------QASSQP-----------AAAASTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RRPLSAAT------------------- ------------------------------------------------------------ ---------------------------------FTTAATGTAVTKTTVISLPQ------- -----------TSQTKPGVVSL-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------L---------------------------------------------------- ------------L----------------------------------------------- ---------------------------------------IKQQ-GMMVR-P-QVTLAQ-- SS-MLTFRG-QPHSHIIVTQPK-------------------------------------- ----------A-VKHL-------------------------------------------- ----------------------------QSGG-------------------TLPAVKQTL VPGAKG-LQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------ISHIS-V-------------------AAQK- ----------------------------------------------NTLNEAGGGSY--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLCEENARILATSSEFVGRVTRSCKDETFLSTSLLTRRALEIGKKFGVSEMGTDVINYI SHAAQQRLQTLLEKTSQVAQQKNRTFK-EDERHVQVSDVRTQLKFFEQLDQVEKQRKEEQ EREVLLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RHREANQTALAAIGPRKKRR-MDSP--------------VRGSGAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSGSSHPGGP-G---------------SGSRHFMRQRITR VNLRDLLFCLENEKGASHSHLLYKGFLK-- >ENSTNIP00000000446 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------ASV----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DTSGDSA QP-AASVIN---------------------------------------GPSAAAASVTSI IRSAS------------------------------------------------------- ------------------------------------------------------------ ----------------HNTATSSQ-QTVPTVTLVR-PPGSTPSSI--------------- ------------------------LP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------ASL-----------------AVSVSSASGSIPNKADGPKPII---- -------------QTVA------------------------------------------- ----------------------------------SA------------------------ ------------------------------------------------------------ -----------------ATATITA------------------------------------ ------------------------------------------------------------ -------------PSTIA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---IST---GMVLVRSESGQLLMFQQQNLAQM------------------------KAQS QSQ----SAITPRLTVPAST-PPV--QVTSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APAASL LTRA-VTP--TTIIKQVSTVHTTGT-TTATLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NTIMLGGTVT PPGQP--------------------------------LGTTTTVQPLTA----------- ---TGTSVTP-------------------------------------------------- --------------TAFT--A--EHSI--------TLR------LC-------------- -------L-----------------------QETLENVKKCRNFLSTLIKLTSNGKQSSE TTANVKELIKKLLEAKIEPEDFTSRLYQELSSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QIST-P-----------AAAASTAL------------AA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTAA------------------- ------------------------------------------------------------ ----------------------------------SSSSTSTALTKTTVISLPQ------- -----------TPHSKPTL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RLFYFSNCLIHLVLDVLNSV IYYFWVQL---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQK-GTITR-P-QMMLAQ-- SP-VMTLQG-PTHSRVIVGQLQTG---------------------------LSSTFTQSS SGHGLMQRLHV-IK---------------------------------------------- -----------------------------------------------------AAVKQTV APSTKG-VQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------VTQSLLH-------------------AAQKS -------------------------------------------------KETAGGTFRLV T----------------------------------------------------------- ------------------------NLTSLGFFPDIMIINGRRICWLANGPRDSSREDLLQ SCI--------------------------------------------------------- ---------------RD-------------------------------DDDINDVASMAG VNLTEESANILATNSELVGTVTRSCKDEMFLSPSLLSRRALEIGKKFGVSELGADVISYI SHATQNRLLNLLEKVSHVAQLKNHNLK-EDGRHEQVCDVRAQLRFFEQLDR--------- -----LKAAKV--------TKSSRRRPLPAGQSRSRQEDPEQLRLKQKAKEMQQQELAQI RHREANLTALAAIGPRKKRK---------------MDSLVRGAGAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SGGSSG---------------PGSRQFMRQRITR VNLRDLLFCLENERGTNRSQLLYKGFLK-- >ENSTRUP00000003317 ------------------------------------------------------------ --------------------------------LS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------PYGRR---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MVLVRSESGQLLMFHQQTLAQM------------------------KAQS QSQ----SAITPRLSAPAST-PPV--QVASLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APAASL LNRA-VAP--ATIIKQVSTVYTTVA-GTTTLQRPPV-------L---------------- ---Q---------------------------------V---------------------- ------------------------------------------------------------ -------------------------------------------------PNAIMLGGTVA APGQP--------------------------------LGTATTVQPGAS---VPQRV--- ---TGTSATP-------------------------------------------------- --------------TAFT------------------------------------------ --------------------------------ETLENVKKCRSFLSTLIKLTSNGKQSSE TTANVKELIKKLLEAKIEAEDFTSRLYRELSSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QTNT-P-----------AAAASTAL------------AA--- --------------------------------------VVL------------------- ---------------------------------RPPLSTAAP------------------ ------------------------------------------------------------ --------------------------------TSTSTSTSTALTK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------QK-GGVTR-P-QMTLAQ-- PP-VMTLQG-PTHSRIIVGQLQTGVGSTLTHSLIFEMLSLAASLSFMSPPSL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLTEESANILATNSELVGTVTRSCKDETFLSPSLLGHRALEIGKKFGVGELGADVVRYI SHAAQQRLQDLLEKVSHVAQLRSHILK-EDGRHEQVSDVRAQLKFFEQLDQLERQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RHREANLTALAAIGPRKKRK-TDAPGSGWGPPPQP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------GGSSG---------------SGSRQFMRQRITR VNVRDLLFCLENERGTNRSQLLYKGFLK-- >ENSKMAP00000017183 ------------------------------------------------------------ --------------------------------MAAGSDLLGDVFFNRKVDKKVVSELLRF PDSELTGASDSYLTPGVYSAANHV------------------------------------ ------------------------AKMGLSQQELPKT----------------------- -------------------------------------------------G---------- ------------------VGVSGGVGNSQ------------------------------- ---------RG------------------------------------------------- ------------------------------------------------------------ -----------------GSSMDGT------------------------------------ ----------------------------------------------------AGLT---- ------------------------------------------------------------ ------------------------------------------STAEPSGVTAAQSQSKPA ------------------------------------------------------------ -------------------------------------------------TASGV------ --------------AAPEAAPR-------------------------------------- -------PAGAETLNGSTAVMNCHVPGG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GRQQS--NSS PP-AGTLVN-GPA---------SASK---------------------------------- -------EG--------------------------AAGVVFRTT---------------- LGAQNAVTPP-------------VTSAQP------------------------------- ----------------------SV-KAVPTVTLVR-PPTQTST----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HDAQSAGNPATVLTS--------------------------- ---------------------------------SSSASVTSTPVI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------KTDPIKTIIQTGVQVVAS -----TDGTVRSPT---------------------------------------------- --VLQS--LKTLAPSTI----AAAPPPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRTIAP------- -------------------------------------QV-LGAQLSQPQRNATT-SV--Q NVQISP---GMVLVRSDSGHYLMIHQQTLAQM------------------------QAQA QSQ----SAMTPRPAATTST-PPV--QVTSLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------TAGTPL LGRS-VTPT-TTIIKQGSSAQTTVT-ATTTLQRPPV-------L---------------- ---Q---------------------------------V---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------IVS----------------- --------------ESVS------------------------------------------ -------------------------------EETLEIVKKCRNFLSTLIKLASSGKQTSE TSANVKELVKSLLESKIEPEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------LPSTQP-----------AATAASAL------------SA--- --------------------------------------VVL------------------- ---------------------------------RPPLASV-------------------- ------------------------------------------------------------ ----------------------------------ATTATGMATTKTTVISLSQ------- -----------TPNSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------I---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GAVVR-P-QVTLTQ-- SP-MVTIRG-QAPNRI-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------F--- ------------------------------------------------------------ ------------------------------------------------------------ -----LSQVVKQIPTGVVKNILLKGQLKVSVYPKKKRTKVHKIKLTV------------- ----------LFYLNRD-------------------------------DDDINDVASMAG VNLSEENARILATGSHLVGMVTRSCTDETFLSVSSLTRITLEIGKKFGVNELGAHVISYI SHATQQRLRILLEKASHVAQQKNTSFK-EDERYEQVSNVRAQLKFFEQLDQLEKQRKDEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAKEMEQLKEAQI RQREANLTALAAIGPRKKRT-ADSP--------------VR------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GSGPSQPGGSS------------------SRQFMRQRITR VNLRDLLFCLENERETSRSQLLYKGFLK-- >ENSGACP00000019908 ------------------------------------------------------------ --------------------------------MQ-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------IA A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------RSPS---------------------------------------------- --VLQN--PRPSL----------A--PP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGTRAIAP------- -------------------------------------QV-LAPRLTQPQQAT-P-NI--Q NIQLPP---GMVLVRSESGQLLVIHQQTLAQM------------------------QAQS QSQ----SAMTPRAAAPTST-PPV--QIASLQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGASP LARP-VAP--TAIIKQGSAVQATVT-PTTTLQRPPI-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------VTLM------ --------CLNRVHTQPG----------------KEPLGTPTPVQAGPAA---TQRA--- ---TGTPVTP-------------------------------------------------- --------------TAVT--A---------------VRRAPFVCMC-------------- -------L-----------------------QETLENVKKCRNFLSTLIKLASSGKQSSE TIANVKELVKNLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSESFI QQSLLP----------------QP-----------AAATSTAL------------TA--- --------------------------------------VVL------------------- ---------------------------------RPPVSTA-------------------- ------------------------------------------------------------ -------------------------------------SSSPAATKTTVISLTQ------- -----------TPPSKPAL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------V---------------------------------------------------- ------------I---------------------------------------------LC CGSASHSSASDC---------------------------AQQH-GTLVR-P-QVALAQ-- SP-MGTLRG-QPHSRIVVSHPQ-------------------------------------- ----------V-VKQQ-------------------------------------------- ----------------------------PTGVSLCLLYKVNLTDFCLCASVTHPAMKQTL AQGAKG-LQV-------------------------------------------------- ------------------------------------------------------------ -----------------------------VSQASLI-------------------AAQR- ----------------------------------------------NKLKEAGGGTFRSV TRSEKLHSAVLNVMQGYKSPWS----------------------------LCIVHEGESP AVIKQRVLPAAGLLNLNVSHTKRCKL---------------------------------- -CHCV------------------------------------------------------- -------------LSRD-------------------------------DDDINDVASMAG VNLSEESDRILATNSELVGAVTRSCKDEAFLSTALLARRALEIGRKFGVSELGPDAANFI AHATQQRLRHLLERVSLVAQHRNGTFK-EDERCEQASDVRTQLRFFEQLD---------- ------KAAKVRILAQRHMTSS-------AAGSRSRQEDPEQLRLKQKAKEMQQQELAQI RQREANLTALAAIGPRKKRK-MDSP--------------VRGASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PGGSGG---------------SGSRQFTRQRITR VNLRDLLFCLENERGTSRSHLLYRGFLK-- >ENSDCDP00000037608 ------------------------------------------------------------ --------------------------------MAAGSDLLDDVFFNTEVDEKVVSDIVGS LESELTGASPGDTAVRARGLGNHVSGAAGS----ANS----------------------- --------------------NVQDNKVGLA-QELVKA----------------------- -------------------------------------------------GK--------- ---GQKLLGSICSRHLVCAGVPGGVINNTRSQAPAAELNPARTGAGG------------- ---------RG----------------AADGRK----------------AS--------- ------------------------------------------------------------ ----------------PGA----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------P------------------------ ------------------------------------------------------------ ------------TLNGGSVVMNSH--------------------------TSVSVPAAPA TP---------------------------------SAG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------------------------------------ ---AVPPVNNGPG---------TVVKGHGAALPP--------------SS-------GTV IQTSL------------------------------------------------------- LST----TST-------------VIS-QT------------------------------- ----------------------SC--AGPAVTLVR-PPMQAAGPVGTPNGSGGSVLTAGV AVAHLPL-----SSATAAVTSGLPV----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------NKSESPK------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AAVPTTVLPGSAGAPV-AK SPVLQNAATRASVPPNI----AAS---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------ATIRAIAP------- -------------------------------------QV-LAPRLPNAQPGT-P-NI--Q NIQLPP---GMVLVRSESGQLLMIHQQTLAQM------------------------QA-- QN------AMAPRPATPTST-PPV--QIASVQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTPI ITRQ-ITP--TTIIKQTQPAQPTVQAATTSLQRPPV-------LRSAFVLNIHSVFTVSV CRVQ-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETLENVKKCKNFLSTLIKLASSGKQSSE TAANVKELVKDLLEGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSASFI QQSQLQ------------QPSTQP--------------TSTAL------------TA--- --------------------------------------VVLGGSATQRTAIQPAPTVVKT PSA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---AATAATATTPAAVPIL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------Q---------------------------------------------------- ------------Q----------------------------------------------- ---------------------------------------PQQQ-GAMVR-P-QVSIAQ-- TP-MVTLRG-QP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------Q-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------NRITLTLSLTEIISVNVFTV HIKVFLSVFFFFFKNRD-------------------------------DDDINDVASMAG VNLSEESARILATNSDLVGAVMRSCKDEAFLYTSSLNRRMLEIGRKYGVNELGPEVINFV SHATQQRLKNLLEKVSEIAQQKNLSYK-EDERYDQASDVRTQLKFFEQLDQAEKQRKEEQ EREMLMKAAK----------------------SRSRQEDPEQARLKQKAKEMQQQELAQM RQRDANLTALAAIGPRKKRK-LDLQ--------------TGGAVTE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSTSGSAASGASGS---------------GVSRQFTRQRITR VNLRDLLFCLENERETSHSHLLYKAFLK-- >ENSCHAP00000050116 ------------------------------------------------------------ --------------------------------MAAGSDLLDDVFFNTEVDEKVVSDIVGS LESELTGSGHGNSAVRVQGVGNHISNSSGS----ANS----------------------- --------------------SVQDNKMGLA-QELVKA----------------------- -------------------------------------------------G---------- ------------------AGVPGGVINNTRSQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------GSTMDAA------------------------------------ ----------------------------------------------------VGTT---- ------------------------------------------------------------ -------------------------------------------SAAGS-GT--------- ----------QVEINQGKAGAGNAVLMAIPNHGAGSGQKGTS------------------ ---------------------------------GMP------------------------ ------------------------------------------------------------ ------------TLNGSNVVINSH--------------------------SSGSVPATPG TT---------------------------------ASSINSVGST--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------VP------------------------------------------------- ------------------------------------------------------------ ---AVTVVNNGPG---------SVVKGQTIVLPS--------------SA-------STV IHTSL------------------------------------------------------- MNTQNVVTST-------------VIANQT------------------------------- ----------------------SCLTTGPTVTLVR-PPMQTPGPITTQNGSNNSVLTANV NVAHLAL-----SNTSTPVSSGLQI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------NKSESPKTII---- -------------QTTTQT-----G----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------SPTVLASPGNLTLGQPMQSTLQPGTIGAASA--------------V-GK SPVLQN-MTRTSVPSTI----SAS---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRAIAP------- -------------------------------------QV-LAPRLPNAQQNQ-P-NI--Q NIQLPP---GMVLVRSESGQLLMIHQHTLAQM------------------------QA-- QSQ----GAMATRPATPTSS-PPV--QITSVQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTPI IARQ-VTP--TTIIKQGSPAQTTVQ-ATTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------NIMLGGTGA AP---------------------------------------------------------- -----TVGTPP--------PVQPGKAVTQKVVAPRA------------------------ --------------LAAT-TT--------------------------------------- --------------------------------ETLENVKKCKNFLSTLIKLASSGKQSSE TAANVKELVKSLLEGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSGAFI QQSQLQQQQTQQPQQQQSQPAPQP--------------TSTAL------------TA--- --------------------------------------VVLGGSATQRTAIQPAPTHMKT PTATVAATGTPSQ-------------------HHP------------------------- ------------------------------------------------------------ -----------------------------------------------VISLTQTGQNKPS LIL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------QQP-GAALR-P-QVTIAQ-- SS-MVTLRG-QPH----------------------------------------------- -----------------------------------------HRMFTPVVKHLSAGSLIRP G----------------------------------------------------------L APGTKV------------------------------------------------------ ------------------------------------------------------------ -----------------------------------VSVSG---------PHSLASAAQK- ----------------------------------------------NKLKEAGGGSF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGAVTRSCKDEAFLFTDSLRRKMLEIGRKYGITELGPDVINFV SHATQQRLQNLLEKVSEVSQQKNIYYK-EDERYDQVSDVRTQLKFFEQLDQMEKQRKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQHELNQM RQRDANLTALAAIGPRKKRK-VESP--------------SSGAGAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSGSAASGASGA---------------GGSRQFTRQRIIR VNLRDLLFCLENERETSHSHLLYKAFLK-- >ENSHHUP00000085528 MIKNGNIIDVWCGSFPFGNASRTTTQCNPVCTVVPIFRRAISSGCDSLNANCNNSSQTVN LVITNQSTLESDVSDGVSNRFTRLTSECSRVKMAAGSDLLDDVFFNTEVDEEVVSDLVGS LESELTGSGRGNSSVRVQAAANNIDNSVVG----RNS----------------------- --------------------NVQDSEMGLS-QELAKP----------------------- -------------------------------------------------G---------- ------------------TGVPGAVINSRRSK---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------GSTMYAA------------------------------------ ----------------------------------------------------VGTT---- ------------------------------------------------------------ -------------------------------------------AAGSS-KTAGHSPSKTG ------------------------------------------------------------ -------------------------------------------------EVSGVVTVVPD HGAGIRKTG--------------------------------------------------- -------AAVVQTLNGRSVVINSH--------------------------NSGSV----- -----------------------------------AALVSSASST--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------VP------------------------------------------------- ------------------------------------------------------------ ---AVAVVNNGPS---------SVVKGN-VILPS--------------TS-------STV IQTPV------------------------------------------------------- M--HKAVTST-------------VISSQL------------------------------- ----------------------SVLNSVPTVTLVR-PPMQTPGTVTSQSGSNNTVLIRSV NVAH-------------PLSSEAQI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------NKLESPKTTI---- -------------QTTSQV-----T----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------APSV-----------------------------------------V-GK SLVLQN--VRTSIPSTI----AAC---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------SGIKAIAP------- -------------------------------------QV-FSPRLPQPQQNA-S-NI--Q NFQLPP---GMVLVRSESGQLLMIHQQTLAQM------------------------QS-- QSQ----SAMTPRAATPTSS-PPV--QITSAQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTPM MSRQ-VTPT-TTITKQGSLALTTVQ-ATTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------PNTIMLGGAAA TPGQAP-------------------------------------VQP-CSA-AVTQRAGTP GA-AGTPGAP-------------------------------------------------- --------------TVVS-TT--------------------------------------- --------------------------------EILENVKKCKNFLSTLIKLASSGKQSSE TTANVKELVKSLLEGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSAAFI QQSQLP------------HAGAQP------------AASSKAL------------TA--- --------------------------------------VVLGGTAT-------------- -----------AQRSRLNS---SSPGAMGTMHQSP------------------------- ------------------------------------------------------------ -----------------------------------------------VISLAQ------- -----------TPHSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------M---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GAMAR-P-QVTLAQ-- SP-MVTLRG-QPHSHIIMGQPQ-------------------------------------- ----------V-VRQL-------------------------------------------- ----------------------------QT----------------------VPVVKQAL APGAKV------------------------------------------------------ ------------------------------------------------------------ -------------------------------------TLG---------PQSMLSVVLK- ----------------------------------------------NRQKEAEGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESARILATNSEVVGMVTRSCKDEAFLHTSSLTQRVHEIGRRLGVTDLGPEVINYV SHATQHRLQNLLEKVTVVAQQKNITFK-EDDKCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELNQI RQKEANMTALAAIGPRKKRK-MNSP--------------VSGTGAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------DLYSGPSPSGGYSS---------------GGSRP-QRQRITR VNLRDLLFCLENESETSRSHLLYKGFLK-- >ENSHHUP00000045140 ------------------------------------------------------------ --------------------------------MAAGSGSLEDVFYDTEVDDKVVSDLVGS LESELTGSGRGNSAARVQAAGNHIGKSSVG----GHS----------------------- --------------------NVQDSKMGLS-QELVQP----------------------- -------------------------------------------------G---------- ------------------TRVQGGVINSAR------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------STMGTA------------------------------------ ----------------------------------------------------AGTT---- ------------------------------------------------------------ -------------------------------------------AAGSS-VTAGHSLSKTG ------------------------------------------------------------ -------------------------------------------------TAGGVVTVVPD HGEWIGKTG--------------------------------------------------- -------SAGVQTLNGSSVVMNSH------------------------------------ ------------------------------------SLVSSASG---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----VTVVNNGPG---------SVVKGN-VFLPS--------------TS-------SAV IQTSL------------------------------------------------------- M--DNAVTST-------------VI----------------------------------- -------------------------NSVPTVTLVR-PPMQTPGGVASLSGS-NAFLTSSV NVAH-------------PACSGAQI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------NKPESPKTTI---- -------------QKTAQV-----TGTGAALGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------S------------------------------------------------- -------------PSTI----AIS---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRAIAP------- -------------------------------------QV-LAPRLPQPQQNA-P-NI--Q NIQLPP---GMVLVRSESGQLLMIHQQTLAQM------------------------QA-- QSQ----SPMTPRPATPTST-PPV--QITSVQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGMPL MARQ-VTP--TTIIKQGSPAQTTV------LQRPPV-------L---------------- ---Q----------QVGTHLTPLFSLIISPSPLSLISS---------------------- ------------------------------------------------------------ -------------------------------------------------PET-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LENVKKCKNFLSTLIKLASSGKQSSE TTASVKDLVKSLLEGKIEAEEFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSTAFI QQSQLP------------QASVQP------------ASSSTAL------------TA--- --------------------------------------VVLGGTAA-------------- -----------AQRLPLNSTTTTSPGAKGTMHQSP------------------------- ------------------------------------------------------------ -----------------------------------------------VISLAQ------- -----------TPHSKPCL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------M---------------------------------------------------- ------------V----------------------------------------------- ---------------------------------------PQQQ-GALAS-T-QVTLAQ-- SP-VVTLRG-QSHSHVIMGHPQ-------------------------------------- ----------S-VRLLCNCSF-------------------PP-----------------P SC---------ALCLSV----------CIS----------------------VPVVKQAL APGAKV------------------------------------------------------ ------------------------------------------------------------ -------------------------------------TLG---------RQSMLSVAQK- ----------------------------------------------NKLKEASGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESAHILATNSELVGAVTRSCKDEAFLYTTSLTRRVQEIGRRFGVTDLGPEVINYV SHATQQRLQNLLEEVTEVAQQKNITFK-EDDKYEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELNQI RQKEANMTALAAIGPRKKRK-MESP--------------GSG------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SGPSSSGGASS---------------GGSRP-QRQRITR VNLRDLLFCLENERETSSSHLLYKGFLK-- >ENSELUP00000016499 ------------------------------------------------------------ --------------------------------MAAGSNLLDDVFFNAEVDEKVVSDLVGS LESELTGSGRGNSAVRVQAAANHIDNTAVG----GNS----------------------- --------------------NVQDNKIGLS-QELATP----------------------- -------------------------------------------------G---------- ------------------TCVQGGVI-STRSE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------GSTMDAA------------------------------------ ----------------------------------------------------TGTT---- ------------------------------------------------------------ -------------------------------------------APGTS-MTARHSQSQTG TFSDAVTAVSN------------------------------------------------- -----------------------------------PR--------TTIE----------- ------KTG--------------------------------------------------- -------PAGVQTLNGSSVLMNSQ--------------------------NSEHV----- -----------------------------------TTLVSSASCT--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------VP------------------------------------------------- ------------------------------------------------------------ ---ALTVVNNGPG---------SVAKGN-AILPS--------------TS-------STV IQTSL------------------------------------------------------- M--QNAVTPT-------------VISSLP------------------------------- ----------------------SVLNSVPTVTLVR-PPMQTPGIVPSQSRSSNAFLTTSV SVSH-------------PAISGAHI----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------NTLDSSKTII---- -------------QTTSPV-----T----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TPSV-----------------------------------------VMGA PAVLQN--VRTTIASSI----AAS---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------CGIRAIAP------- -------------------------------------QV-LAPRHPLPQQNA-P-NI--H NIQLPP---GMVLVRHENGQLLMIHQQTLAQM------------------------QAQS QSQ----SAMTPRPATTNST-PPA--QISSVQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------G----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TIMLGGAAA TPGHTP-------------------------------------VQPGLAA-ALTQRAGTP GA-TGTSGTP-------------------------------------------------- --------------TASN-IT--------------------------------------- --------------------------------ETLDNVKKCKNFLSTLIKLASSGKQSAE TTANVKQLVKSLLEGHIEVEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSAAFI QQSQLP------------QASVKP------------ASSS-AL------------TA--- --------------------------------------VVLGGASI-------------- -----------AQRQPQNSSTTSSPGAKGTLPQSP------------------------- ------------------------------------------------------------ -----------------------------------------------GISLAQ------- -----------TPQSKPGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------I---------------------------------------------------- ------------T----------------------------------------------- ---------------------------------------SQQQ-GAMAR-P-RGTLAQ-- SP-VVPLRG-QHNSRIVMGQTH-------------------------------------- ----------V-VKPL-------------------------------------------- ----------------------------QT----------------------VSVVKQAL APGTKV------------------------------------------------------ ------------------------------------------------------------ -------------------------------------TVG---------PLSMASVAQK- ----------------------------------------------NKLKEAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGSVTRSCKDEAFLYTSSLTRRVQEIGRRFGVTDLGPEVINYV SHATQQRLQDLLEKASEVAQQRNITFK-EEDKHDQTSDVRAQLKFFEQLDQMERQRKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELNQI RQREANMTALAAIGPRKKRK-MDSP--------------LSGATAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GTGSGPSPSAGANS---------------GGSRP-QRQRITR VNLRDLLFCLENERESSRSHLLYRGFLK-- >ENSSFOP00015007079 ------------------------------------------------------------ --------------------------------MAAGSDLLDEVFFNTEVDEKVVSDLVGS L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------DGAACAAARTPSLCVRARVCACLCIIMCAYAY VWRASERTSARALVYFATYLRARCTRLDSTRALSCCFRSXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPAAGIRPIAP------- -------------------------------------QV-LAPRLPQATQNP-P-NI--Q NIQLPP---GMVLVRSDSGQLLMIHQQTLAQM------------------------QAQS QSQ----SAMTPRPATPTST-PQV--QIAPVQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------GPGTSI LTRQ-MTP--TTIIKQTSPGQASVP-ATTTLQRPPV-------L---------------- ---Q---------------------------------VRSQDPQ---------------- ------------------------------------RCGKGWVYIPSLYCRSMAC----- ------------------------------------------------SSTP-------- ------------------------------------------------------------ -----TPGAT-------------------------------------------------- --------------VTTT--T--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLASSGKQSSE TAANVKDLVKSLLEGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRAMTPDSAAFI ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------XXXXXTA SASVVSAAGTFQ------------------------------------------------ -------------------------------QP--------------VISLPQ------- -----------TGHAKPG---------------------------QTAPL---------- ------------------------------------------------------------ ------------------------------------VT---------------------- ------------------------------------------------------------ -------A-----------------------R---------------------------- ------------------------------------------------------------ ---------------------------------------PPQQ-GAVVR-PPQVTLTQ-- TP-MVTLR--PPHSRIVLGQPQ-------------------------------------- ----------VQVKPL-------------------------------------------- ----------------------------QT----------------------VPLVKQSA LAGAK------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------VPAPPVATLSAAQK- ----------------------------------------------NKPKDAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGAVTRSCKDEAFLYTATLHRRLLEIGKKYGIVELGPEVVNLV SHATQQRLQDLLEKVSQVAQQKNISFK-DDSRHEQISDVRAQLKFFEQLDHMEKQKKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQM RQRDANLTALAAIGPRKKRK-LDWP--------------GGGAGAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSSPSLSGGSGA---------------AASRQFTRQRITR VNLRDLLFCLENEKGTSHSHLLYRAFLK-- >ENSPKIP00000017193 ------------------------------------------------------------ --------------------------------MAAGSDLLDEVFFHTEVDEKVVSDLVGS LESELAGSGHANSQAKGQALANHV----TGFGARGNT----------------------- --------------------NVQESKVGLA-QEVAEA----------------------- -------------------------------------------------G---------- ------------------AGVQGGVINNTRSP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------GSAMDAA------------------------------------ -------------------------------------------------------T---- ------------------------------------------------------------ -----------AGIASATDSEPLAGLSQSKTVAVSAIGTT-------------------- ----------------------------VSNHATVR------------------------ ------------------------------------------------------------ -----GKSG--------------------------------------------------- -------TSAVQTLNGSS-VINSH--------------------------SSGSVAAFAG T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------PEPASG-------------------GTENVAS------------------ ------------------------------------------------------------ ---AVTVVNNGPG---------SAVRGG-AVLPP--------------------A-SSTV IQTSF------------------------------------------------------- MNTQNIVTST-------------VITPQA------------------------------L ----------------------AL-STAPGVALVR-PPMQAAGSATTQNGN-NAVLTSGV SVAALPTPGIPSQSVTVSVTTGAQVIKSESPKTLPQGLVSSAGGLTLGQATQPAPIAKS- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PA-------------LQA------------------------------ -------VTRAPTPSSP----AAS---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------AGIRAIAP------- -------------------------------------PV-LAPRLSQAAPSQ-P-NI--Q NIQLPP---GMVLVRSDSGQLLMIHQQTLAQM------------------------QAQS QSQ----SAMAPRPATPTST-PPV--HITSVQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------GPGTPI LARQ-VTP--TTIIKQASGVQASVQ-TTTTLQRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NPILLGGAA- -PGSS--------------------------------VGTPATVQPG-----VAQRT--- --VTGTPGAT-------------------------------------------------- --------------VTAT--T--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLASSGKQSSE TAANVKDLVKNLLEGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRAMTTDSAAFI QQSQLQ------------QP---------------APASTTSL------------TT--- --------------------------------------VVM------------------- --------SSAAQ--------------------RP------TTVTPASVATVT------- --------GTLQ------------------------------------------------ -------------------------------QP--------------VISLAQ------- -----------AGHSKPGQ--------------AASLVLHQSQQQQT------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------AMVR-PPQVTITQ-- TP-MVTLR--QPHSRIVLGQPQ-------------------------------------- ----------VQMKPL-------------------------------------------- ----------------------------HT----------------------VPLVKSSA SVGAR------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------GPTPPMAALSATQK- ----------------------------------------------NKLKDAGGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEENARILATNSELVGAVTRSCKDEAFLYTATLHRRVLNIGKKYGIAELGPEVVNFV SHATQQRLQDLLEKVSQIAQQKNFSFK-DDSRYEQISDVRSQLKFFEQLDQMEKQRKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRK-LDWP--------------GTGAGAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGVSPSLSGATGT---------------GSSRQFTRQRITR VNLRDLLFCLETERESSHSNLLYRAFLK-- >ENSELUP00000004592 ------------------------------------------------------------ --------------------------------MAEGSDLLDEVFFNTEVDEEVVSNLVGS LESELSGWVHGNPWVRCQTVVKH--SSGTG----GNS----------------------- --------------------NVQQSKRGLA-QGVAKA----------------------- ------------------------------------------------------------ --------------------VQWGVISNTRSQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------SSAMDASSAESDSSAGHGQS-NTVAVSANI------------- ----------------------------------------IAPLPNHGGK---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AITTTAP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------GM---------------------------AIQTSLLNNG------QS PSSVAVSATSHIIKA----------------------------------EAPKTII---- -------------QTAP------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------VVVT------------------------------------- -----------NPS-------------FQS------------------------------ -------APRTPTPVTV----AAN---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GAIRAIAP------- -------------------------------------QM-LAPRLPQTSPNQ-P-NV--Q NIQLPP---GMVLVRSESGQLLMIHQQTLAQM------------------------QAQS HSQ----GAMAPRPDTPTST-AQV--QITSVQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTPI LSRQ-LAPTSTTIIKQGMSVPTCAP-ITTTLQRPP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------VLQ--VQVQIVVSWFVR------LCLSEGVFHSSTMGAS CELLFLFL-----------------------QETMENVKKCKNFLSTLIKLASSGKQSEE TVTNVKDLVKDLLEGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRKLTPDSARFI EQSGLQ------------Q----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------QTSAPTPQTVVLGSP--------PPRPAA-------------------- ------------------------PSMIPNLQP--------------VNS---------- ---------------KQG---------------------------QPASL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-GAMVR-PLQM------ TP-MVTLRGQHPHSRIVLGQPQ-------------------------------------- ----------V--KRL-------------------------------------------- ----------------------------PM----------------------VPMVKPGV LSGSKL------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SSGAASPA---------TAVQQ- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGAVTRSCKDEAFLHASALTRRILEMGKKFGVSDLGPEVVSYV SHATQTRLTNLLEKVSEVAQQRNINLK-EDSRYEQTSDVRAQLKFFEQLDQMEKQRREEQ QREILMKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELFQL RQKEANLTALAAIGPRKKRR-TEA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSSPSASGSGSS---------------GASRQFVRQRITR VNLRDLLFCLENERDTSHSHLLYRGFLK-- >ENSHHUP00000074005 ------------------------------------------------------------ --------------------------------MAAGSDLLDEVFFNAEVDEKVVRDLVGS LESELSG--HENPEARSQTVAKHMASSGTG----FNA----------------------- --------------------NVQQNERGLA-QEVAK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------GSAMDASSSEPDSSAGHGQG-KTVAVSASI------------- ----------------------------------------ITPLPNHGGKVASSTT---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------QTLNGGS-LMNCH--------------------------NSGSAVSLTG T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------P----------------------------LSSSC---------------- ---------------TSSGNA-LV------------------------------------ ---AVTVVNNGPGL-SKG--HAS------AVMPP--------------------SLNTTI IQTSF------------------------------------------------------- VNSQNVVTSSHAASLGTGPAISHI------------------------------------ ---------------------------------VR-PSMQTAGSGTAMNGP-NA------ ----------------------------------------------------------GL PFDC-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------LNNG------QS PTSLAVSAGSHITMA----------------------------------EAPKTII---- -------------QTG-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------AVT------------------------------------- -----------NPS-------------FQS------------------------------ -------APTASTPVTV----AAS---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGSRSIAQ------- -------------------------------------QV-LAPRHPQTSPNQ-P-NV--Q NIQLPP---GMVLVRSESGQLLMIHQQTLAQM------------------------QSQS QSQ----GVMAPRPATPTST-PPF--QITSVQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTPI LTRQ-VTP--TTIIKQGSPVPTSAP-VTTTLQKPP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPMIVVGAA- -AGTS--------------------------------MG---TALPG-----ATQRT--- --VTASPGTT-------------------------------------------------- --------------VTLA--T--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLASSGNQSSE TAANVKDLVKDLLEGKIEVEDFTNRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QHSGLQ------------Q----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------QASATTPTTVVLDSP--------ALRPAA-------------------- ------------------------QTIRPHLQP--------------VIS---------- ---------------KPG---------------------------QTTPM---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-GAMVR-PLQV------ TP-MVTLRGQPPHSHIMLGQPQ-------------------------------------- ----------VQLKQL-------------------------------------------- ----------------------------QT----------------------VPVVKPGV LTGSKS------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SPGAASLA---------TAVQK- ----------------------------------------------NKLKEA-GVTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGAVTRSCKDEAFLHTSTLTRRILEIGKKFGVSDLGPEVVNYV SHASQTRLQNLLEKVSEVAQQKNINFK-EDSRYEQTSDMRAQIKFFEQLDQMEKQRKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELFQL RQKEANLTALAAIGPRKKRK-MEAA--------------AAAAGAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSSPSASGSGSS---------------GASRQFIRQRITR VNLRDLLFCLENERDTSHSHLLYKGFLK-- >ENSFHEP00000005286 ------------------------------------------------------------ --------------------------------MD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ASTASTDTKTGQKPG-KPPVV----------------- -------------------------------------GDGVSFPLNYP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVG--------------------------------------------------- -------TYSAQTFNGSQ-TMNAH--------------------------NSGSVAPLEG ATATSVTGN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------SSSGST-VI------------------------------------ ---AAAALGTGTAL-SKRPSG--------SSLPP--------------SS-------NSV IQTPL------------------------------------------------------- VNADG-----------------GPGA----------------SQAA-------------- ---------------------------GPTVTLVR-PPMQTVGSGTTLNGSST------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPVVAANATNQTGA---------------------------GTQNPPVNHGP-PGTSAP -----LSAGPHIIKA----------------------------------EPPAAII---- -------------PPAPQP----------------------------------------- ------------------------------------------------------------ -----------------AASPGFI---------------------NAPR----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------PGAPGMAP------- -------------------------------------QM-LAPRLPQTSPGQ-P-SV--H NIQLPP---GMVLVRSESGQLLMIPQQALAQM----------------------QAQAQA Q------GGMAPRTAMPASV-SA-------GQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTTI VSRQ-VSQ--STIIRPGCPAPASLA-ATTALHRPSI-------L---------------- ---P-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------TSV------- -----------------GTTV---PGMAPRTFTPT------------------------- ---AGTTVTS-------------------------------------------------- --------------VTVS--K--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLASSGKQSTE TAATVSNLVKELLEGTLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASVA-----------VSSASATS------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------APRLTA-------------------- ------------------------PGSRPQLQP---------------------T----- -------------VTQ-G---------------------------HTTSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAILR-P-QVTLAA-- ATGLMALRN-QTPGRIVVGQHQ-------------------------------------- ---------------L------------------------------------------QP G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------P-----------LRPEGTLVSKPVSAVALT-------------------QAQK- ----------------------------------------------NKLREA-GGNF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDEAFLSCAALQRRALEIGARHGVTELGAEVVNYI SHATQQRLLNLLEKVSLVAQQKNVNFKQEDDGYEQSSDVRAQLRFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRKNLDSP--------------SSSASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGSSLPGAAGS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSHSHFLYKGFLK-- >ENSGAFP00000030159 ------------------------------------------------------------ --------------------------------MD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ASTGSTDTKRGHEPG-KPLVV----------------- -------------------------------------GDGISFPPNQP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVV--------------------------------------------------- -------SYSVQTFNGSQ-TMNSH--------------------------NTGSIAPLEG AKATSGTGNNNS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SSST-VI------------------------------------ ---SAAAASTGAVL-SKGQTG--------VSFSP--------------SS-------NSV IQTPL------------------------------------------------------- INSDG--------------------A----------------NQAA-------------- ---------------------------GPTVTLVR-PPMQTAGSGTTLNGSSA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPAVAANATNQTGI---------------------------GMQNPPVNNG------QP -----VSAGSHIIKA----------------------------------EPPTTII---- -------------QSAPQP----------------------------------------- ------------------------------------------------------------ -------------ATAAAAAPSSI---------------------TAPR----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PLGMS---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AAGAPGITT------- -------------------------------------QM-LAPRLPQASPAQ-P-SV--H NIQIPP---GMVLVRSESGQLLVIPQQALAQMQ--------------------AQAQAQA Q------GGMAPRTATPTNV-SA-------TQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTTI INRQ-VSP--GAIIRPGCPPPVSLT-ATTALHRAPI-------L---------------- ---S-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSV------- -----------------GATV---PGLAPRTLTPT------------------------- ---PGTTVTS-------------------------------------------------- --------------VTVS--K--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLASSGKQSTE TAATVRELVKDLLEDKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASVA-----------VSSTSATS------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------GPRLTT-------------------- ------------------------PGSRPQLQP---------------------T----- -------------VSQ-G---------------------------QTTSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAMLR-P-QVTLPT-- AP-MMALRN-QTPGRIMVGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVQ-----------LRPEVTLVSRQVSAVALT-------------------QAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSGFVGAVTHSCKDEAFLSFALLQRRMLQIGMKYGVTEFSTEVVNYV SHATQHRLLNLLEKVSHVAQQKNINFK-EDDSYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKKKNLDSP--------------SSSASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGSSLTGTAGS---------------SGSRL-TRQRITR VNLRDLLFCLENERFTSHSHFLYKGFLK-- >ENSPFOP00000005672 ------------------------------------------------------------ --------------------------------MD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ASTGSTDTKRGHEPG-KPLVV----------------- -------------------------------------GDGISFPPNQP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVA--------------------------------------------------- -------SYSVQTFNGSQ-TMNSH--------------------------NSGSVTPLEG AKATSGTGNNNN------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------SSSST-VI------------------------------------ ---SAAAGSTGAVL-SKGLTG--------VSLPP--------------SS-------NSV IQTPL------------------------------------------------------- MNSDG-----------------VSAA----------------SQAA-------------- ---------------------------GPTVTLVR-PPMQTAGSGTTLNGSST------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPAVAANASNQTGI---------------------------GTQNPPVNNG------QP -----VSAGSHIIKA----------------------------------EPPTTII---- -------------QSAPQSAA--------------------------------------- ------------------------------------------------------------ -------------APAAA---SSI---------------------SAPR----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PLGMA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AAGAPGITT------- -------------------------------------QM-LAPRLPQTSPGQ-P-SV--H NIQIPP---GMVLVRSESGQLLVIPQQTLAQM------------------------QAQA Q------GGMVPRTATPTNV-SA-------AQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGATI ISRQ-VSP--GTIIRPGCPPPVSLA-ATTALHRAPI-------L---------------- ---P-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSV------- -----------------GATV---PGLAPRTLTPT------------------------- ---PGTTVTS-------------------------------------------------- --------------VTVS--K--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLASSGKQSTE TAATVRELVKDLLEDKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASVA-----------VSSTSATC------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------GPRLTT-------------------- ------------------------PGSRPQLQP---------------------T----- -------------VSQ-G---------------------------QTTSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAMLR-P-QVTLPT-- TP-MMALRN-QTPGRIMVGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVQ-----------LRPEVTLVSRQVSAVALT-------------------QAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDEAFLSYALLQRRMLEIGMKYGVTELGTEVVNYV SHATQQRLLNLLEKVSQVAQQKNINFKQEDDSYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKKKNLDSP--------------SSSASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGLSLTGAAGS---------------SGSRL-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSPREP00000024331 ------------------------------------------------------------ --------------------------------MD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ASTGSTDTKRGHEPG-KPLVV----------------- -------------------------------------GDGISFPSNQP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVS--------------------------------------------------- -------SYPVQTFNGSQ-TMNFH--------------------------NSGSVAPLEG AKATSGTGNNNN------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SSST-VI------------------------------------ ---SAAAVSTGAVL-SKGLTG--------VSLPP--------------SS-------NSV IQTPL------------------------------------------------------- MNSDG-----------------VSVA----------------SQAA-------------- ---------------------------GPTVTLVR-PPMQTAGSGTTLNGSST------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASSAVAANALNQTGI---------------------------GTQNPPVNNG------QP -----VSTGSHIIKA----------------------------------EPPTTII---- -------------QSAPQPAA--------------------------------------- ------------------------------------------------------------ -------------AAAAAAAPSSI---------------------SAPR----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SLGMA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AAGAPGITT------- -------------------------------------QM-LAPRLPQTSPGQ-P-SV--H NIQIPP---GMVLVRSESGQLLVIPQQTLAQM------------------------QAQA Q------GGMVPRTTTPTNV-SV-------AQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTTI ISRQ-VSP--GTIIRPGCPPPVSLA-ATTALHRAPI-------L---------------- ---S-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSV------- -----------------GATV---PGLAPNTLTPT------------------------- ---PGTTVTS-------------------------------------------------- --------------VTVS--K--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLASSGKQSTE TAATVRELVKDLLEDKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASVA-----------VSSPSATC------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------GPRLTT-------------------- ------------------------PGSRPQLQP---------------------T----- -------------VSQ-G---------------------------QATSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAMLR-P-QVTLPT-- AP-MMALRN-QTPGRIMVGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVQ-----------LRPEVTLVSRQVSAVALT-------------------QAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDEAFLSYALLQRRMLEIGMKYGVTELGTEVVNYV SHATQHRLLNLLEKVSQVAQQKNINFKQEDDSYEQSSDVRAQLKYFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKKKNLDSP--------------SSSASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGSSLTGAAGS---------------SGSRL-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSPMEP00000032733 ------------------------------------------------------------ --------------------------------MD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ASTGSTDTKRGHEPG-KPLVV----------------- -------------------------------------GDGISFPPNQP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVA--------------------------------------------------- -------SYSVQTFNGSQ-TMNSH--------------------------NSGSVTPLEG AKATSGTGNNNNS----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------SSSSST-VI------------------------------------ ---SAAAGSTGAVL-SKGLTG--------VSLPP--------------SS-------NSV IQTPL------------------------------------------------------- MNSDG-----------------VSAA----------------SQAA-------------- ---------------------------GPTVTLVR-PPMQTAGSGTTLNGSST------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPAVAANASNQTGI---------------------------GTQNPPINNG------QP -----VSAGSHIIKA----------------------------------EPPTTII---- -------------QSAPQPA---------------------------------------- ------------------------------------------------------------ ---------------AAAAAPSSI---------------------SAPR----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PLGMA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AAGAPGITT------- -------------------------------------QM-LAPRLPQTSPGQ-P-SV--H NIQIPP---GMVLVRSESGQLLVIPQQTLAQM------------------------QAQA Q------GGMVPRTATPTNV-SA-------AQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGATI ISRQ-VSP--GTIIRPGCPPPVSLA-ATTALHRAPI-------L---------------- ---P-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSV------- -----------------GATV---PGLAPRTLTPT------------------------- ---PGTTVTS-------------------------------------------------- --------------VTVS--K--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLASSGKQSTE TAATVRELVKDLLEDKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASVA-----------VSSTSATC------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------GPRLTT-------------------- ------------------------PGSRPQLQP---------------------T----- -------------VSQ-G---------------------------QTTSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAMLR-P-QVTLPT-- TP-MMALRN-QTPGRIMVGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----AVQ-----------LRPEVTLVSRQVSAVALT-------------------QAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NRD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDEAFLSYALLQRRMLEIGMKYGVTELGTEVVNYV SHATQQRLLNLLEKVSQVAQQKNINFKQEDDSYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKKKNLDSP--------------SSSASAEV------------- ----------------------------------------------TMKTVINVCTIYAC APAAARA---------GCIR---------------------------------------- ------------------------------------------------------------ ----------------------------------------ILGHLSLSLSLFFFPTYPVL ISATSGKN---------------------------------------------------- ------------------------------ >ENSXCOP00000023265 ------------------------------------------------------------ --------------------------------FA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----S---GMVLVRSESGQLLVIPQQTLAQM------------------------QAQA Q------GGMAPRTATPTNV-S-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTTI ISRQ-VSP--GAIIRPGCPPPVSLA-ATTALHRAPI-------L---------------- ---P---------------------------------V---------------------- -----------------------------------CRC---------------------- -----------------------------------------------SL----------- --------------------L---PGLAPRTLTPT------------------------- ---PGTTVTS-------------------------------------------------- --------------VTVS--KV-------------------------------------- ----------R--------------------SETMENVKKCKNFLSTLIKLASSGKQSTE TAATVRELVKDLLEDKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLT------------QPASVA-----------VSSTSAMS------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------G-P--------APRLMT-------------------- ----------------------PPPGSRAQLQQ---------------------T----- -------------VSQ-G---------------------------QTTSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAMLR-P-QVTLPT-- AP-MMALRN-QTPGRIMVGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP GE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----A------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDEAFLSYALLQRRMLQIGMKYGVTELGTEVVNYI SHATQQRLLNLLEKVSHVAQQKNINFK-EDDSYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKKKNLDSP--------------SSSAS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGSSLPGTVGS---------------SGSRL-TRQRITR VNLRDLLFCLENERFTSHSHFLYKGFLK-- >ENSXMAP00000010027 ------------------------------------------------------------ --------------------------------MAVGPSLLDELFSQTGENKAVVCHPPRS VESQLSL----------------------------------------------------- ---------------------------------------------------------FIS LSW---------HEAAVNYMVIVP-------------------------G---------- ------------------------------------------------------------ ---------RG--------------------------------------ASA-------- -----GVCREKQQ------------------------------------------TYSSL PPSHSSVGGSPLSEFPNGSAMDASTGSTDTKRGHEPG-NPLVV----------------- -------------------------------------GDGISFPPNQP------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVA--------------------------------------------------- -------SYSVQTFNGSQ-TMNSH--------------------------NSGSVAPLEG AKATSGTGNNNSS----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------SSSSTT-VI------------------------------------ ---SAAAVSTGAVL-SKGLTG--------VSLPP--------------SS-------NSV IQTPL------------------------------------------------------- MNSDG-----------------VSAA----------------SQAA-------------- ---------------------------GPTVTLVR-PPMQTAGSGTTLNGSST------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPAAAANATSQTGT---------------------------GTQNPPVNNG------QP -----VSAGSHIIKA----------------------------------EPPTMII---- -------------QSAPQP----------------------------------------- ------------------------------------------------------------ ----------------AAAAPSSI---------------------SAPR----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PLGMS---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AAGAPGITT------- -------------------------------------QM-LAPRLPQASPGQ-P-SV--H NIQIPP---GMVLVRSESGQLLVIPQQTLAQM------------------------QAQA Q------GGMASRTATPTNV-S-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTTI ISRQ-VSP--GAIIRPGCPPPVSLA-ATTALHRAPI-------L---------------- ---P---------------------------------V---------------------- -----------------------------------CRC---------------------- -----------------------------------------------SLRTGL------- -----------------WATV---PGLAPRTLTPT------------------------- ---PGTT----------------------------------------------------- ------------------------------------------------------------ --------------------------------ETMENVKKCKNFLSTLIKLASSGKQSTE TAATVRELVKDLLEDKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLT------------QPASVA-----------VSSTSAMS------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------GPRLTT-------------------- ----------------------PPPGNRAQLQQ---------------------T----- -------------VSQ-G---------------------------QTTSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAMLR-P-QVTLPT-- AP-MMALRN-QTPGRIMVGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP GE---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----A---------------PEVALVSRQVSAVALT-------------------QAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------NRD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDEAFLSYALLQRRMLQIGMKYGVTELGTEVVNYV SHATQQRLLNLLEKVSHVAQQKNINFK-EDDSYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKKKNLDSP--------------SS--S---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGSSLPGTAGS---------------SGSRL-TRQRITR VNLRDLLFCLENERFTSHSHFLYKGFLK-- >ENSSDUP00000029075 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MDASTASTDSSPGHDPG-KTLVV----------------- -------------------------------------SDGATSLPNHL------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RKVG--------------------------------------------------- -------SYSVQTFNGSQ-TMNSH--------------------------NSGSAALLGG TTVTSGTGN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SSVP-AV------------------------------------ ---SVAAVNSGPVL-SKGLAS--------AIMPP--------------SS-------NSV IQTHL------------------------------------------------------- MNSQS-----------------VVASAQPV------------SQPT-------------- ---------------------------GHTVTLVR-PPMQTAGLGATLNGNNN------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ TSPAVVANTTGQSGI---------------------------SIQTPLVNNG------QP SNSVSVSARSHIIKA----------------------------------EPPTTII---- -------------QSASQP----------------------------------------- ------------------------------------------------------------ -----------------TVTPGAV---------------------SAPRT---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------PATV----AAG---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRALTP------- -------------------------------------QM-LAPRVPQTSPGQ-P-SI--H NIQLPP---GMVLVRSESGQLLMIPQQTLAQM------------------------QAQA Q------GGMTPRTATPTNV-PP-------GQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGN-I ISRQ-VAP--SNIIRQGCPTPTSLA-ATTTLHRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSV------- -----------------GAAV---PGMTTRTVTQT------------------------- ---AGTTVTS-------------------------------------------------- --------------VTVS--K--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLASTGKQSTE TAASVRELVKDLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASSP-----------VASTSPTPT----------PTT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------APRLTS-------------------- ------------------------PISRPQLQP---------------------G----- -------------VNKPG---------------------------QIPPL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAVLR-P-QVTLPT-- TP-MVTLRN-QAPGRIMLGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VP-----------VRPDVSPASKQISAAALT-------------------PAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDETFLSCTMLQRRMLEIGRRHGVTDLGAEVVNFV SHATQQRLQNLLEKVSQVAQQKNVNLK-EDGNHEQSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRRILDSP--------------SSSAVAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGSSLSGGAGS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSSLDP00000014585 ------------------------------------------------------------ --------------------------------MAVRPGPLDELFLHTEVNKAVVCHPVRS VESQLS------------------------------------------------------ ------------------------------------------------------------ --VFCHNNHWGRHEAAGNYMAIVP-------------------------G---------- ------------------------------------------------------------ ---------QG--------------------------------------G---------- ------------------------------------------------------------ --------------SPHGSTMDASTASTDSSPGHDPG-KTLVV----------------- -------------------------------------SDGAAPLPNHL------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----RKVG--------------------------------------------------- -------SYSVQTFNRSQ-TMNSH--------------------------NSGSAALLGG TTVTSGTGN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SSVP-AV------------------------------------ ---SVAAVNSGPVL-SKGLAS--------AIMPP--------------SS-------NSV IQTHL------------------------------------------------------- MNSQS-----------------VVASAQPV------------SQPT-------------- ---------------------------GHTVTLVR-PPMQTAGLGATLNGNNN------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ TNPAVVANTTGQSGI---------------------------SIQTPLVNNA------QP SNSVSVSARSHIIKA----------------------------------EPPTTII---- -------------QSASQP----------------------------------------- ------------------------------------------------------------ -----------------TVTPGAV---------------------SAPRT---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------PATV----AAG---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRALTP------- -------------------------------------QM-LAPRVPQTSPGQ-P-SI--H NIQLPP---GMVLVRSESGQLLMIPQQTLAQM------------------------QAQA Q------GGMTPRTATPTNV-PP-------GQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGN-I ISRQ-VTP--SNIIRQGCPTPTSLA-ATTTLHRPPV-------L---------------- ---Q---------------------------------VT--------------------- --------------------------------LSVCRC---------------------- --------------------------------------------HIISGN---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETMENVKKCKNFLSTLIKLASTGKQSTE TAASVRELVKDLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASSP-----------VASTSPTPT----------PTTNL- ----------------------------------KPSQ---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAVLR-P-QVTLPT-- TP-MVTLRN-QAPGRIMLGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP GEDVNL------------------------------------------------------ ------------------------------------------------------------ -KIIRLY----------------------------------------------------- ----------------------VSPASKQISAAALT-------------------PAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDETFLSCTMLQRRMLEIGRRHGVTDLGAEVVNFV SHATQQQLQNLLEKVSQVAQQKNVNLK-EDGNHEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKKRILDSP--------------SSS------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGSSLSGGAGS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSATEP00000023870 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MNSH--------------------------NSGSAAPLGG TTVTSGTGN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SGGP-AV------------------------------------ ---SVTAVNSGAVL-SKGLAT--------AIMPP--------------SS-------NSV IQTPL------------------------------------------------------- MNSQS-----------------VVTSAPPV------------NQAA-------------- ---------------------------GPTVTLVR-PPMQTPGPGVTLNGNNN------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPAVVASTTGQPGV---------------------------GIQTPHVNNG------PP SSSVSVSAASHIIKA----------------------------------EPPTTII---- -------------QSAPQT----------------------------------------- ------------------------------------------------------------ -----------------AVTPGAV---------------------SAPRA---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------SATV----AAV---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRTLAP------- -------------------------------------QM-LAPRLPQTSPGQ-P-SV--H NIQLPP---GMVLVRSESGQLLMIPQQALAQMQ--------------------AQAQAQA Q------GNIAPRSATPSNV-PP-------GQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGNTI ISRQ-VTP--S----------------TTTLHRPPI-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------STV------- -----------------GPAV---PGMTARTVTQT------------------------- ---AGTTVTS-------------------------------------------------- --------------VTVS--K--------------------------------------- --------------------------------ETMENVTKCKNFLSTLIKLASTGKQSTE TAASVRQLVKDLLEGKLEAEEFTSRLYKELKSSPQPYLVPFLKRSLPTLRQLTPDSAAFI QQSQLP------------QPASGP-----------VSSTSPTP------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------TSP--------TPRLTA-------------------- ------------------------PISRPQFQP---------------------G----- -------------INKPG---------------------------QTPSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAMLR-P-QVTLPT-- TP-IVTVRN-QAPGRIIVGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VP-----------VRPEVPPVSKQVSAAALT-------------------LAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDETFLSCTILQRRMLEIGRRYGVTDLGAEVVNYV SHATQQRLQNLLEKVSQVAQQKNFSFK-EGDTYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRKILDSP--------------SSSSAAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGTSLSGGAGS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSACIP00000015771 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------MVLVRSESGQLLMIAQQALAQM------------------------QAQA Q------GDMAPRATTPTNV-PP-------GQ---------------------------- ------------------------------------------------------------ ----------------------------------------------------VRAPGNTV ISRQ-VTP--STIIRPGCPAPTPLT-ATTTLHRPPI-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETIENVKKCKNFLSTLIKLASTGKQSTE TAASVRELVKDLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLA------------QPASGS-----------VSSTSPTP------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------APRLPA-------------------- ------------------------PVSRPQLQP---------------------G----- -------------INKPG---------------------------QMTSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAILR-P-QVTLPA-- TP-I-TLRN-QAPGRIMLGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GEDVTTILFF---------------------YDDDINDVASMAG VNLSEESANILATNSITVGAVTHSCKDEAFLSCAILQRRMLEIGRRHGVTELGPEVVNYV SHAAQQRLQNLLEKVSQVAQQKNISFK-EDNNHEQSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRKNLDSP--------------SSSAS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGPSLSGGPAS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSMZEP00005001168 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MDASTASTDSNTGHDPG-KTPVV----------------- -------------------------------------SSGVTFLPNHQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVG--------------------------------------------------- -------SYSAQTFNGSQ-TMNSH--------------------------NSGNAATLRG TIVTSGTGS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SSSA-AI------------------------------------ ---SVTAVNSGPVL-SKGLAG--------VTMPP--------------SS-------NSV IQTPL------------------------------------------------------- MNSQS-----------------VVASAQPV------------SQAT-------------- ---------------------------GPTVTLVR-TPMQTVGSGAVLNGNNS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPSVAASASSQTGI---------------------------GMQTPLVNNG------QP SSSVAISAGTHIIKA----------------------------------EPPTTIT---- -------------ESAPQP----------------------------------------- ------------------------------------------------------------ -----------------TVTPGAV---------------------TVPRT---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------SAAA----AAA---T-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRALAP------- -------------------------------------QM-LAPRLPQATPGQ-P-SI--H NIQLPP---GMVLVRSDSGQLLMIPQQALAQM------------------------QAQA Q------GDLAPRATTPTNV-PP-------GQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------TPGNTV ISRQ-VTP--STIIRPGGPAPASLT-ATTTLHRPPI-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSV------- -----------------GAAV---PGMTSRTVSQT------------------------- ---AGTTVTS-------------------------------------------------- --------------VAFS--K--------------------------------------- --------------------------------ETIENVKKCKNFLSTLIKLASSGKQSTE TAATVRELVKDLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLA------------QPASGS-----------VSSTSTTP------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------APRLPT-------------------- ------------------------PVSRPLLQP---------------------G----- -------------INKPG---------------------------QMPSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RALLR-P-QVTFPT-- TP-VMTLRN-QAPSHIVLGQQQ-------------------------------------- ----------VHLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VP-----------LRPEGPPGSKQVLVAALT-------------------PAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSITVGAVTHSCKDEAFLSCAVLQRKMLEIGRRYGVTELGPEVVNYV SHAAQQHLQNLLEKVSQVAQQKNITFK-EDNNHEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKKRNLESP--------------SSSASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGPSLSGGPAS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSHBUP00000010335 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MDASTASTDSNTGYDPG-KTPVV----------------- -------------------------------------SSGVTFLPNHQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVG--------------------------------------------------- -------SYSAQTFNGSQ-TMNSH--------------------------NSGNAATLRG TIVTSGTGS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SSSA-AI------------------------------------ ---SVTAVNSGPVL-SKGLAG--------VTMPP--------------SS-------NSV IQTPL------------------------------------------------------- MNSQS-----------------VVASAQPV------------SQAT-------------- ---------------------------GPTVTLVR-TPMQTVGSGAVLNGNNS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPSVAASASSQTGI---------------------------GMQTPLVNNG------QP SSSVAISAGTHIIKA----------------------------------EPPTTIT---- -------------ESAPQP----------------------------------------- ------------------------------------------------------------ -----------------TVTPGAV---------------------TVPRT---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------SAAA----AAA---T-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRALAP------- -------------------------------------QM-LAPRLPQATPGQ-P-SI--H NIQLPP---GMVLVRSESGQLLMIPQQALAQM------------------------QAQA Q------GDLAPRATTPTNV-PP-------GQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGNTV ISRQ-VTP--STIIRPGGPAPASLT-ATTTLHRPPI-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSV------- -----------------GAAV---PGMTSRTVSQT------------------------- ---AGTTVTS-------------------------------------------------- --------------VAFS--K--------------------------------------- --------------------------------ETIENVKKCKNFLSTLIKLASSGKQSTE TAATVRELVKDLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLA------------QPASGS-----------VSSTSTTP------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------APRLPT-------------------- ------------------------PVSRPLLQP---------------------G----- -------------INKPG---------------------------QMPSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RALLR-P-QVTLPT-- TP-VMTLRN-QAPSHIVLGQQQ-------------------------------------- ----------VHLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VP-----------LRPEGPPGSKQVLVAALT-------------------PAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSITVGAVTHSCKDEAFLSCAVLQRKMLEIGRRYGVTELGPEVVNYV SHAAQQHLQNLLEKVSQVAQQKNITFK-EDNNHEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKKRNLESP--------------SSSASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGPSLSGGPAS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSPNYP00000025945 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MDASTASTDSNTGHDPG-KTPVV----------------- -------------------------------------SSGVTFLPNHQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVG--------------------------------------------------- -------SYSAQTFNGSQ-TMNSH--------------------------NSGNAATLRG TIVTSGTGS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SSSA-AI------------------------------------ ---SVTAVNSGPVL-SKGLAG--------VTMPP--------------SS-------NSV IQTPL------------------------------------------------------- MNSQS-----------------VVASAQPV------------SQAT-------------- ---------------------------GPTVTLVR-TPMQTVGSGAVLNGNNS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPSVAASASSQTGI---------------------------GMQTPLVNNG------QP SSSVAISAGTHIIKA----------------------------------EPPTTIT---- -------------ESAPQP----------------------------------------- ------------------------------------------------------------ -----------------TVTPGAV---------------------TVPRT---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------SSAA----AAA---T-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRALAP------- -------------------------------------QM-LAPRLPQATPGQ-P-SI--H NIQLPP---GMVLVRSDSGQLLIIPQQALAQM------------------------QAQA Q------GDLAPRATTPTNV-PP-------GQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGNTV ISRQ-VTP--STIIRPGGPAPASLT-ATTTLHRPPI-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSV------- -----------------GAAV---PGMTSRTVSQT------------------------- ---AGTTVTS-------------------------------------------------- --------------VAFS--K--------------------------------------- --------------------------------ETIENVKKCKNFLSTLIKLASSGKQSTE TAATVRELVKDLLEGKLEAEEFTSRLYKELNSSPQPHLVPFLKRSLPALRQLTPDSAAFI QQSQLA------------QPASGS-----------VSSTSTTP------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------APRLPT-------------------- ------------------------PVSRPLLQP---------------------G----- -------------INKPG---------------------------QMPSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RALLR-P-QVTLPT-- TP-MMTLRN-QAPSHIVLGQQQ-------------------------------------- ----------VHLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VP-----------LRPEGPPGSKQVLVAALT-------------------PAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSITVGAVTHSCKDEAFLSCAVLQRKMLEIGRRYGVTELGPEVVNYV SHAAQQHLQNLLEKVSQVAQQKNITFK-EDNNYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKKRNLESP--------------SSSASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGPSLSGGPAS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSACLP00000029056 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MNSH--------------------------NSGNAATLRG TIVTSGTGS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SSSA-AI------------------------------------ ---SVTAVNSGPVL-SKGLAG--------VTMPP--------------SS-------NSV IQTPL------------------------------------------------------- MNSQS-----------------VVASAQPV------------SQAT-------------- ---------------------------GPTVTLVR-TPMQTVGSGAVLNGNNS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPSVAASASSQTGI---------------------------GMQTPLVNNG------QP SSSVAISAGTHIIKA----------------------------------EPPTTIT---- -------------ESAPQP----------------------------------------- ------------------------------------------------------------ -----------------TVTPGAV---------------------TVPRT---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------SAAA----AAA---T-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRALAP------- -------------------------------------QM-LAPRLPQATPGQ-P-SI--H NIQLPP---GMVLVRSDSGQLLMIPQQALAQM------------------------QAQA Q------GDLAPRATTPTNV-PP-------GQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETIENVKKCKNFLSTLIKLASSGKQSTE TAATVRELVKDLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSATFI QQSQLA------------QPASGS-----------VSSTSTTP------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------APRLPT-------------------- ------------------------PVSRPLLQP---------------------G----- -------------INKPG---------------------------QMPSL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------QQ-RALLR-P-QVTFPT-- TP-VMTLRN-QAPSHIVLGQQQ-------------------------------------- ----------VHLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------P-----------LRPEGPPGSKQVLVAALT-------------------PAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------D-------------------------------DDDINDVASMAG VNLSEESANILATNSITVGAVTHSCKDEAFLSCAVLQRKMLEI-RRYGVTELGPEVVNYV SHAAQQHLQNLLEKVSQVAQQKNITFK-EDNNHEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKKRNLES------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------P-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSONIP00000025602 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SGAVLNGNNS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPSVATSASSQTGI---------------------------GMQTPLVNNG------QP SSSVAISAGTHIIKA----------------------------------EPPTTIT---- -------------ESAPQP----------------------------------------- ------------------------------------------------------------ -----------------TVTPGAV---------------------TVPRT---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------SATA----AAA---T-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRALTP------- -------------------------------------QM-LAPRLPQATPGQ-P-SI--H NIQLPP---GMVLIRSDSGQLLMIPQQTLAQM------------------------QAQA Q------GDLAPRATTPTNV-PP-------GQWLGPRSTCTQLMKT-------------- ----------------PVEQNIR------------------LYNLQCMG----------- -------------------------------------------SSI-----VCRAPGNTV ISRQ-VTP--STIIRPGCPAPASLT-ATTTLHRPPI-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSV------- -----------------GAAV---PGMTSRT----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETIENVKKCKNFLSTLIKLASSGKQSTE TAATVRELVKDLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLTRSLPALRQLTPDSAAFI QQSQLA------------QPASGS-----------VSSTSTTP------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------DSP--------APRLPT-------------------- ------------------------PVSRPLLQP---------------------G----- -------------INKPG---------------------------QMPSLVSKIHLDVDS GSSCSTDNLIIWHSTYLNGERTSFSCLESLCSPEEKSCLRNKGLLGKSIAKHGEDKGKKS WEKPPIKSERTLHSLLRLPAESPVSHLCYIRLYLTDV----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAILR-P-QVTLPT-- TP-VMTLRN-QAPSHIVLGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP GEDVSL------------------------------------------------------ ------------------------------------------------------------ ------TTLL---------------------------NVCVCVCAPF------------- --IGLVP-----------LRPEGPLGSKQVLVAALT-------------------PAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSITVGAVTHSCKDEAFLSYAILQRKMLEIGRRYGVTELSPEVVNYV SHAAQQRLQNILEKVSQVAQQKNITFK-EDNNYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRK--DSP--------------SSSASAEL------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------DLIEGKSSKILS------------------------------SRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSAPEP00000033340 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M---------------------VQ--LWTH---------- ------------------RRPARTPLRDTTLAAKHLFSGGATFLPNHQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVG--------------------------------------------------- -------SHSAQTFNGNQ-TMNSH--------------------------NSGSAAPPGG TTVTSSSSN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SSSP-AM------------------------------------ ---SVTAVTSGPVL-SKGPAA--------ASVPP--------------SA-------NTV IQTPL------------------------------------------------------- MNSQS-----------------VVASA----------------QTT-------------- ---------------------------GATVTLAR-PPMQTAGSGATLNGNNT------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPGVAVSAA---GV---------------------------GAQTPLVNNS------QP SNSV---SGSHIIKA----------------------------------EPPTTII---- -------------QAAPQP----------------------------------------- ------------------------------------------------------------ -----------------AA--GAA---------------------SAPRT---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------PVSV----AAG---A-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRALTP------- -------------------------------------QM-LAPRLPQTSPGQ-P-SV--H NIQLPP---GMVLVRSESGQLLMIPQQALAQM----------------------QAQAQA Q------GGMAPRTTTPTNV-PP-------SQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGNTI ISRQ-VSS--STIIRQGCPTPASLA-ATTTLHRPPI-------L---------------- ---P-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------STV------- -----------------GAAV---PGITPRTVSQT------------------------- ---TGATVTS-------------------------------------------------- --------------VTLS--K--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLASSGKQSTE TAASVRELVKDLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASGP-----------ASSTSPTP------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------APRPTA-------------------- ------------------------PISRPQLQP---------------------G----- -------------LNKPG---------------------------QTASL---------- ------------------------------------------------------------ ------------------------------------I----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQP-RAMLR-P-QVTLPT-- TP-MM-IRN-QVPGRIMLGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VP-----------LRPEVSTVSKQISAAALT-------------------SAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DEDINDVASMAG VNLSEESANILATNSGLVGVVTHSCKDEAFLSCAMLQRRMLEIGKKYGVTDLGVEVVNYV SHATQQRLQNLLEKVSEVAQQRNITFK-EDDNYEQSSDVRVQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANMTALAAIGPRKKRKNLDSP--------------SSSASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGPSLSGGPGS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTNRSHFLYKGFLK-- >ENSAPOP00000000626 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MDASTASTDSATGHDPGSKTLVV----------------- -------------------------------------SGGATFLPNHQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVG--------------------------------------------------- -------SYSAQTFNGNQ-TMNSH--------------------------NSGSAAPPGG TTVTSGSSN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SSSP-AM------------------------------------ ---SVTAVTSGPVL-SKGPAA--------ASVPP--------------SA-------NTV IQTPL------------------------------------------------------- MNSQS-----------------VVASA----------------QTT-------------- ---------------------------GATVPLVR-SPMQTAGSGATLNGNNT------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPGVAVSAA---GV---------------------------GVQTPFVNNS------QP SNSV---SGSHIIKA----------------------------------EPPTTII---- -------------QAAPQP----------------------------------------- ------------------------------------------------------------ -----------------AA--GAA---------------------SAPQT---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------PVSV----AAG---A-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRALTP------- -------------------------------------QM-LAPRLPQTSPGQ-P-SV--H NIQLPP---GMVLVRSESGQLLMIPQQALAQMQ--------------------AQAQAQA Q------GGMAPRTTTPTNV-PP-------SQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGNTI ISRQ-VSS--GTIIRQGCSTPTSLT-ATTALHRPPI-------L---------------- ---P-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SAV------- -----------------GAAV---PGITPRTVSQT------------------------- ---TGATVTS-------------------------------------------------- --------------VTLS--K--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLASSGKQSTE TAASVRELVKDLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASGP-----------ASSTSPTP------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------APRPTA-------------------- ------------------------PISRPQLQP---------------------G----- -------------VNKPG---------------------------QTASL---------- ------------------------------------------------------------ ------------------------------------I----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAMLR-P-QVTLPT-- TP-MM-IRS-QVPGRIMLGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VP-----------LRPEVSTVSKQISAVALT-------------------LAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DEDINDVASMAG VNLSEESANILATNSGLVGVVTHSCKDEAFLSCTMLQRRMLDIGRRYGVTDLGVEVVNYV SHATQQRLQNLLEKVSEVAQQKNITFK-EDDNYEQSSDVRVQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANMTALAAIGPRKKRKNLDSP--------------SSSASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGPSLPGGPGS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSLCRP00005039130 ------------------------------------------------------------ --------------------------------MAVGSGPLDEPYLHTEVNKAVVCHPVKP VESQLS------------------------------------------------------ ------------------------------------------------------------ --FLCHNNHWGRHEAAGNYIAIVP-------------------------G---------- ------------------------------------------------------------ ---------QG--------------------------------------GS--------- ------------------------------------------------------------ -------------ASPHGSTMDASTASTDSTAGHDPG-KPLVV----------------- -------------------------------------SGGVT-LPNHQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVG--------------------------------------------------- -------SYSVQTFNGSQ-TMNSH--------------------------NSGNAAPLGG TTATSGIGN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SSSSTAI------------------------------------ ---AVTAVNSGPVM-SKGLAT--------AIMPP--------------SS-------GSV IQTPL------------------------------------------------------- ------------------------ATAQPV------------SQAT-------------- ---------------------------GPTVTLVR-PPMQTAGSGATLNGNNN------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPALVANTTAPTGI---------------------------AIQTTLVNNS------QP SNSVSVSAGSHIIKA----------------------------------EPPTTII---- -------------QSAPQP----------------------------------------- ------------------------------------------------------------ -----------------AVIP------------------------SAPRI---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------PATV----AAG---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------SGIRAMTP------- -------------------------------------QM-LAPRLPQTSPGQ-P-SI--H NIQLPQ---GMVLVRSESGQLLMIPQQALAQMQA------------------QAQAQAQA Q------GGMAPRAATPTSV-PP-------GQ---VRSHCL------------------- ------------------------------------------------------------ ------------------------------------------------------------ --RQ-VTP--STIIRQGC--PASLA-ATTTLQRPPI-------L---------------- ---Q---------------------------------VTP--PHLRQIISHHVH------ ----------LACYA---------------LFC--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETMDNVKKCKSFLSTLIKLASTGKQSTE TAASVRELVKDLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QLASAP-----------VSSTSLTP------------ST--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------APRLTA-------------------- ------------------------PVSRPQLQP---------------------G----- -------------VSKPG---------------------------QTSSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAMLR-P-QVTLPT-- TP-MVTLRN-QAPGRIMLGQQQ-------------------------------------- ----------VHLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VP-----------VKLEVPSVSKQVCAAALT-------------------PAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDEAFLSCAMLQRRMLEIGRRYGVTDLGAEVVNYV SHATQQRLQSLLEKVSQVAQQKNVNFK-EDDNYEQNSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRKILDSP--------------SS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------SGSGSSLSGGAGS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSLCAP00010045537 ------------------------------------------------------------ --------------------------------MAVRPGPLDKLFLHTEVNKAVVCHPVRS VESQLS------------------------------------------------------ ------------------------------------------------------------ --VLCHNNHWGRHEAAGNYMAIVP-------------------------G---------- ------------------------------------------------------------ ---------QG--------------------------------------GS--------- ------------------------------------------------------------ -------------ESPHGSAMDASTASTDSNTGHDPG-KTLVV----------------- -------------------------------------SGGATSLPNHQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVG--------------------------------------------------- -------SYSVQTFNGSQ-TMNSH--------------------------NSGSAAPLVG TTVTSGTGN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SSGP-AV------------------------------------ ---SVAAVSSGPVL-SKGLAS--------AIMPP--------------SS-------NSV IQTPL------------------------------------------------------- MNSQT-----------------VVASAQPV------------SQAT-------------- ---------------------------GPTVTLVR-PPMQTAGSGGTLNGNNN------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPAVVANTTGQSGI---------------------------GIQTPLVNNS------QP SNPVSVSAGSHIIKA----------------------------------EPPTTII---- -------------QSTPQA----------------------------------------- ------------------------------------------------------------ -----------------AVTPGAV---------------------SAPRT---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------PVTV----AAG---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------SGIRALTP------- -------------------------------------QM-LAPRLPQNSPGQ-P-SI--H NIQLPP---GMVLVRSESGQLLMIPQQALAQM------------------------QAQA Q------GGVTPRTATPTNV-PP-------GQ---VRSH------SLHRRSFILPTIMSH VRDKGSITANVQLAFLPV------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETMENVKKCKNFLSTLIKLASTGKQSTE TAASVRELVKDLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASSP-----------ISSTSTNP------------AT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------SSP--------APRLTA-------------------- ------------------------PVSRPQLQP---------------------G----- -------------ISKPG---------------------------PTPSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAILR-P-QVTLPT-- TP-MVTLRN-QAPGRIVLGQHQ-------------------------------------- ------------LKEL------------------------------------------QP GEEVNL------------------------------------------------------ ------------------------------------------------------------ -K-----SPL---------------------------SVHVCV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------FPWMTYSIYCDFCASTSSCETRGDDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDEAFLSCTLLQRRMLEIGRRYGVTDLGAEVVNYV SHATQQRLQNLLEKVSQVAQQKNVNLK-EDDNYEQSSDVRAQLKYFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRKILDSP--------------SSSAT---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGPSLSGGAGS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSPRNP00000004277 ------------------------------------------------------------ --------------------------------MAESSGPLDELFLHTGVNKAVVCHPARS VESQLS------------------------------------------------------ ------------------------------------------------------------ --FLCHNNHCGRHETAGNYMVIVP-------------------------G---------- ------------------------------------------------------------ ---------QG--------------------------------------G---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ML-SKGLAS--------ATMPP--------------TS-------NSV IQTPL------------------------------------------------------- MNSQS-----------------VMASAHPV------------SQAT-------------- ---------------------------GPTLALVR-PPMQNSGSGLTLSENNA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPAVTANTTGQTSI---------------------------GIQTPLVNNG------QP SNPASVSAGSHIIKA----------------------------------EPPTTII---- -------------QSAAHA----------------------------------------- ------------------------------------------------------------ -----------------AGTPGTV---------------------SAPRN---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------PGTV----TAP---D-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRTPTP------- -------------------------------------QM-LAPRLPQTVAGQ-P-SI--Q NIQLPP---GMVLVRSESGQLLMIPQQALAQMQ--------------------AQAQAQA Q------GGITPRTPAPTNV-PP-------VQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGNPI ISTQ-VSP--STIIRPGCPTPTSLS-ATTTLHRPPV-------F---------------- ---Q---------------------------------VR--------------------- -------------------------------------CL-------------MNCMFYLA KTVSSAATEVDFVLC---------------------------FWQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETIENVKKCKNFLSTLIKLASSGKQSTE TAATVRELVKDLLEAKLEVEEFTSRLYKELNSPPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASGP-----------VSSTSTTS------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------AHRLPT-------------------- ------------------------PITRPQLQP---------------------G----- -------------VSKPG---------------------------QAPSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------SDQQ-RPMLR-P-QVTLTT-- TP-MMAIRN-QAPGRIMLGQQQ-------------------------------------- ----------VQFKEL------------------------------------------QP GE---------------------------------------------------------- ------------------------------------------------------------ ---M-------------------------------------------------------- --------------------PDVPLVSKQISAAGLT-------------------PAQK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSIIVGAVTHSCKDEAFLSFAMLQRRMLEIGKRYGVTDLGAEVVNSV SHATQQRLQNLLEKVSQVAQQKSSNLK-EDDNYRHSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKKKNPDSP--------------SSS------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGPSLHGGPGS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSCSEP00000007330 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MDSTTASADSTTGCDPG-KALVD----------------- -------------------------------------GGGATSLPNHQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVG--------------------------------------------------- -------SYLVQTFNGSQ-TMNSH--------------------------DPGSAAAPHG GTVTSGGAN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SGGP--------------------------------------- -----AAVNSGSVLSSKGLPG--------PIMPP--------------AS-------NSV IQTPL------------------------------------------------------- MNSQS-----------------VVVSTQPA------------SQTT-------------- ---------------------------GPTVTLVR-PPVHT----TTLNGNN-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------IVVTATNTALQS--------------VVGTQPPLVNNG------QS STSVTVSARPHIIKA----------------------------------EPPTTLI---- -------------QSALQT----------------------------------------- ------------------------------------------------------------ -----------------TVTPGAV---------------------STPRS---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------PATV----TAS---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRTLTP------- -------------------------------------QM-LAPRLPQTSPGQ-P-SI--H NIQLPP---GMVLVRSESGQLLMIPQQALAQM------------------------QAQA Q------GGIAPRTATPSNV-ST-------GQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------ATGN-- INRQ-VAP--SAIIRQGCAAPTTLA-ATTTLHRPPI-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSV------- -----------------GVS----PGLTPRTVTQT------------------------- ---AGSTVTT-------------------------------------------------- --------------TTVS--K--------------------------------------- --------------------------------ETMENVKKCKNFLATLIKLASTGKQSTE AAPIVRELVKDLLEGKLEAEEFTSRLYKELKSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQAP------------QTTASP-----------VSSPSLTPAT---------VTT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------SSP--------APRLTT-------------------- ------------------------PISRPQLQP---------------------G----- -------------ISKPG---------------------------LTPTM---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RPILR-P-QVNFPTPS TP-MVTLRN-QAPSRIMLGHQQ-------------------------------------- ----------VQLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VT-----------TRPELP---SQVPAAALT-------------------PANK- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGVVTHSCKDEAFLSCALLQRRMLEIGRRHGVTDLGADVVNFV SHAAQQRLQNLLENVSQVAQQKNVSFK-EDHNCEQSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRKLLDSP--------------SSSAVAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGSSSSVGTGS---------------SASRP-TRQRITR VNLRDLLFCLENERFTSSSHFLYKGFLK-- >ENSSMAP00000020780 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MEASAAGTDSTTGRDPG-KTLVE----------------- -------------------------------------VGGATSLPNHQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GRVG--------------------------------------------------- -------SYSSQTFNGSQ-TMNCH--------------------------NSGSAAPHGG -SVTSGTGGGAP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AV------------------------------------ ---SPAAVHGGPVL-SKGLYG--------AIVPA--------------AS-------NSV IQTPL------------------------------------------------------- VNSQS-----------------VVVQALPVSPATGATGATGATGAT-------------- ---------------------------GATVTLAR-PPAQAAGSGATLNGNNA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AA---------QSGV---------------------------GAHTPLVNDA------QP PTSLSVSARLHTIKA----------------------------------EPPATIS---- -------------QSAPQP----------------------------------------- ------------------------------------------------------------ -----------------AVTPASA---------------------GAPRA---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------PAPA----AVG---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------VGIRALTP------- -------------------------------------QM-LVPWLPPTSARP-P-GI--H NIQLPP---GMVLVRSESGQLLVIPQQALAQM------------------------QAQA Q------GGTAPRTATPTNV-PP-------GP---------------------------- ------------------------------------------------------------ ------------------------------------------------------SPGN-- ISRQ-VAP--STIIRQGCPAPTSLA-ATTTLHRPPI-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------RSV------- -----------------GAAV---PGMTPRTGSHT------------------------- ---AGTTVTS-------------------------------------------------- --------------V-----K--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLASTVSQSTE TAATVRELVKELLEGKVEAEEFTSRLYKELNSQPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------KPGSQR-----------VSSISPTP------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GNP--------TPRLTA-------------------- ------------------------PISRPQLQP---------------------G----- -------------VSKPG---------------------------QTPSL---------- ------------------------------------------------------------ ------------------------------------L----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------QQQ-RAMLR-P-QVTVPS-- TP-MVTLRN-QAPGRIMLGQQQ-------------------------------------- ----------VQHKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VP-----------VRPELLPVSRQVSAAALT-------------------PAQR- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEENANILATNSGLVGAVTHSCKDEAFLSCAMLQRRMLEIGRSYGVTDLGAEVVNYV SHATQHRLQNLLEKVSQVAQQKNVNLK-EDDNNEQGSDVRAQLKFFEQLDLLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRKNLDSP--------------SSSAAAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGP-------L---------------SGSRP-TRQRITR VNLRDLLFCLEEERFTSRSHFLYKGFLK-- >ENSGACP00000013177 ------------------------------------------------------------ --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- -------------------------------------QM-LAPRLPQTNPGQ-P-SIGLH NIQLPP---GMVLVRSESGQLLMIPQQALAQM------------------------QAQA Q------GGLTPRAATPTSA-PP-------AQ---------------------------- ------------------------------------------------GS---------- ------------------------------------------RSS---------APGN-- ISRQ-VAP--GP-IRQSCAAPT-----TTTLHRPPV-------L---------------- ---Q---------------------------------VR--------------------- --------------------------------LSV------------------------- -----------------------------------------------GVKSPV------- -----------------GAAV---PGITPRAVSQA------------------------- ---AGTTVAS-------------------------------------------------- --------------ITMS--K--------------------------------------- --------------------------------ETIENVKKCKNFLSTLIKLASTGKQSTE TAASVRELVKELLEGRLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QTPSGP-----------VPSTSPVP------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------APRLTA-------------------- ------------------------PVSRPPLQL---------------------G----- -------------ISKP------------------------------------------- ------------------------------------------------------------ -----------------------------------VV----------------------- ------------------------------------------------------------ -------I-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------SQQP-RAMLK-P-QVALPT-- TP-MGTLRN-QAPGRIMLGQQQ-------------------------------------- ----------VHLKGL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VL-----------VRPESSPFSKQVSAASLS-------------------LAQR- ----------------------------------------------NELKQP-GATF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------EDDINDVASMAG VNLSEESANILATNSRLVGVVTHSCKDEAFLSFSVLQKTMQEIGRRHGVTDLGAEVVNFV SHATQHRLMDLLEKVSQVALQKNLNSK-EDGKYEPSSNVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRKILDSP--------------SSSSAAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------ASGPSLSGGGGP---------------SASRP-TRQRITR VNLRDLLFCLENERSTSHSHFLYKGFLKTQ >ENSBSLP00000028202 ------------------------------------------------------------ --------------------------------MS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------GMVLVRSESGQLLMIPQQALAQM------------------------QAQ- ----------VPRSATPTGV-PPICA---SSQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------SAGNTI ITRQ-VAP--S----------------TTTLHRPPI-------L---------------- ---Q---------------------------------VN--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------SLAVVISDSDLSTYSSCSSCKLETIENVKKCKNFLATLIKLASSGKQSTE TAASVKELVKDLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPTLRQLTPDSDAFI QQSQTP------------QSASGL-----------ASSTSPSP------------AT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------SSL--------APRLTA-------------------- ------------------------PVSRPQLQP---------------------G----- -------------VSKPG---------------------------QTPSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAMLR-P-QVALPT-- TP-IVTLRN-QAPGRIILGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP GEVVSLS----------------------------------------------------- --------------------------PALGCVWVTSGTDHCLIFLPVPVRPGATAAYFLA QK---------------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------KLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDEAFISCALLQRRMLEIGRRYGVTDLGAEVVNYV SHATQQHLQKLLEKVSQVAQQKNVSFK-GDNNYEQSSDVRVQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRKILDPS--------------SSSSAAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SGGAGS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSTNIP00000004874 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------RALTP------- -------------------------------------QV-LAPRLPLTSPGQ-P-SV--H NIQIPP---GMVLIQSESGQLLLIPQQALAQM------------------------QAQA Q------GGVAARTATPTNA-SP--GQVSFSQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------ATGNTV VSKP-VAP--STIIHPGCAAPTSLP-VTTTLHRPPV-------L---------------- ---Q-------------------------------------------------------- --------------APGKVADFILFPLYLVV----------------------------- --------------------------------------------------SIS------- -----------------GAS-----GTVPRTVNKT------------------------- ---AGTTVTT-------------------------------------------------- --------------IAMS--K--------------------------------------- --------------------------------ETIENVKKCKNFLSTLMKLASTGKQSPE TAALVRELVKDLLDGKLEAEEFTSRLYKELNSSPQPYLVPFLMRSLPALRQLTPDSTAFI QQSQLP------------QPASAP-----------VTSASAIS------------ST--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------SSP--------APRLPV-------------------- ------------------------PVSRPQFQP---------------------G----- -------------VTKPG---------------------------QSTSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAVLG-P-QVTLAT-- TP-MVTLRN-PAPSHIVLGQQR-------------------------------------- ----------VQLKDLQPAIFTKVVLR-------------PP------------GSVRQP G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SKQASAPALT-------------------PSQR- ----------------------------------------------NQLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSELVGVVTRSCKDEAFLSASLLQRRMLEIGRRFGVTDLGAEVVKYV SHAAQQRLQSLLEKVSLVAQQRHISFK-EDERYEQDGDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQL RQREANLTALAAIGPRKKRKFLDSP--------------SSSS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AEGSGPGPCLSSSAVSGSRP-VRQRITR VNLRDLLFCLENERFTSRSHFLYKSFLNPG >ENSTRUP00000029009 ------------------------------------------------------------ --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DAPTISTDSKAGDDHG-KT-------------------- ------------------------PV-----------SSGLTALTGHS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKIG--------------------------------------------------- -------SYPVQTFSGSQ-TMNSH--------------------------NSGSTA---- ------------VTEG----------ST--------------------------SES--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GQ------------------------------------------- -------------NPM-------------------------------------------- ---------------SKGLIS--------VVTPP--------------TS-------NSV IQTPV------------------------------------------------------- MTSQN-----------------VV---QPM------------SQAA-------------- ---------------------------GPTVTLAR-PPMQSGRSGMNLNGDNN------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ VTPS----TSCQAGT---------------------------AVQTSVLNNN------QP TNSVTVSTGLHVIKA----------------------------------EPP-------- --------------------QAIQT----------------------------------- ------------------------------------------------------------ ----------SSQL---AVIPG------------------------TPRN---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------LGTV----AAG---Q-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGVRALTP------- -------------------------------------QA-LAPRLPHTSPGQ-P-SV--H NIQIPP---GMVLVQSESGQLLMIPQQALAQV------------------------QAQA QAQAQAQGGGAPRTATPTNV-SP-------VQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGGTV ISKP-VAP---TIIHQGCPAPTSLP-ATTTLHRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSI------- -----------------GAS-----GTIARTINKT------------------------- ---AGTTVTT-------------------------------------------------- --------------VTMS--K--------------------------------------- --------------------------------ETIENVKKCKNFLSTLMKLASTGKQSPE TAALVRELVKDLLDGKLEAEEFTGRLYKELNSSPQPYLVPFLMRSLPALRQLTPDSTAFI QQSQLP------------QPSSAP-----------VTSASPIS------------ST--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------APRLPV-------------------- ------------------------PVNRPQFQP---------------------G----- -------------VTKLG---------------------------QTTSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RAVLR-P-QVPLAT-- TP-MVTLRN-PAPAHMVLGQQR-------------------------------------- ----------VQLKDL------------------------------------------QP GEDDTLTASHVSSCV------------------------------CVC------------ -------VGVVFIR--------TVLCPT-------------------------------- ---G-------------------------------------------------------- --------------------PVRPLASKQVSATALT-------------------PAQK- ----------------------------------------------NQLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSELVGVVTHSCKDEAFLSTSLLQRRILEIGRKYGVTDLGAEVVKYV SHATQQRLQNLLEKVSLVAQQRHISFK-EDDNYEQGSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQL RQREANLTALAAIGPRKKRKFLDSP--------------SSSSGAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTCPSLSSGAGT---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKSFLK-- >ENSORLP00020034139 ------------------------------------------------------------ --------------------------------MA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------STDSSAGHEPG----------------------- ----------------------ETP--DA--------GDRVTSLPNHS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVD--------------------------------------------------- -------SNSAQTFNGSQ-TMNSH--------------------------NSGSAA---- --------------------------------------------------------AVER TATSATG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------TPAAGSG-------------------------------------------- ------------------------------------------------------------ ----------GAVL-SKGL----------LTMPP--------------SS-------GGV IQAPL------------------------------------------------------- LNSDGG---------------GVAAAAQAV------------SQAP-------------- ---------------------------GHTVTLIR-QPMQTPGSSVTLNGNNSA------ ------------------------------------------------------------ -------NSAAAAG------------------------STTDQAAVG------------- ------------------------------------------------------------ ----------------------------VQ---------------------------TNN AAP--------------------------------------------------------- ----------HIIKA----------------------------------EPPTTLL---- -------------QSSPQPVL--------------------------------------- ------------------------------------------------------------ ---------------------------------------------SAPQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PPSMA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AGGLRAPNP------- -------------------------------------QM-LAPRLPQTSTGQ-P-SV--H NIQLPP---GMVLVRSESGQLLMIPQQALAQM------------------------QAQA Q------GGMAPRPSTPTNM-PL-------GQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------PLGNTI ISRQ-VSQ--SAISRQSCPAPAPLT-ASTTLHRPPI-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------STV------- -----------------GAT-----PVAQRTLSQP------------------------- ---VGNTITT-------------------------------------------------- --------------VTVS--K--------------------------------------- --------------------------------ETLENVKKCKNFLATLIKLASSGKQSSE TAASVRELIKELLEGKVEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQHP------------QAASGP-----------VSSSSS--------------ST--- --------------------------------------VVQ------------------- ------------------------------------------------------------ -----------------------GSP--------APRLAA-------------------- ------------------------PAIKPQLQP---------------------A----- -------------TNKPG---------------------------HPTPLLVQ------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SQQ-RTMLR-P-QLATAS-- TP-MMAVRN-QVPARIIVGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VP-----------LRPDGALVSKQVFAAALT-------------------SAQR- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDEAFLSCAVLQRRMLEISKRHGVTDLGTDVVTFI SHATQQRLQNLLEKVSFVAQQKNINLK-ESENYEQSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRKNLDSP--------------SSSASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGSSLMGGAGS---------------SSSRP-TRQRITR VNLRDLLFCLEDERFTSRSHFLYKGFLK-- >ENSORLP00000016972 ------------------------------------------------------------ --------------------------------MA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------STDSSAGHEPG----------------------- ----------------------ETP--DA--------GDRVTSLPNHS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVG--------------------------------------------------- -------SNSAQTFNGSQ-TMNNH--------------------------NSGSAA---- --------------------------------------------------------AVER TATSAPG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------TPAAGSG-------------------------------------------- ------------------------------------------------------------ ----------GAVL-SKGL----------LTMPP--------------SS-------GGV IQAPL------------------------------------------------------- LNSDGD---------------GVAAAAQAV------------SQAP-------------- ---------------------------GHTVTLIR-QPMQTPGSSVTLNGNNSA------ ------------------------------------------------------------ -------NSAAAAG------------------------STTDQAAVG------------- ------------------------------------------------------------ ----------------------------VQ---------------------------TNN AAP--------------------------------------------------------- ----------HIIKA----------------------------------EPPTTLL---- -------------QSSPQPVL--------------------------------------- ------------------------------------------------------------ ---------------------------------------------SAPQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PPSMA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AGGLRAPNP------- -------------------------------------QM-LAPRLPQTSTGQ-P-SV--H NIQLPP---GMVLVRSESGQLLMIPQQALAQM------------------------QAQV Q------GGMAPRPSTPTNM-PL-------GQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------PLGNTI ISRQ-VSP--SAISRQSCPAPTPLT-ASTTLHRPPI-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSV------- -----------------GAT-----PMAQRTLSQP------------------------- ---VGNTITT-------------------------------------------------- --------------VTVS--K--------------------------------------- --------------------------------ETLENVKKCKNFLATLIKLASSGKQSSE TAASVRELIKELLEGKVEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQHP------------QAASGP-----------VSSSSS--------------ST--- --------------------------------------VVQ------------------- ------------------------------------------------------------ -----------------------GSP--------APRLAA-------------------- ------------------------PAIKPQLQP---------------------A----- -------------TNKPG---------------------------HPTPLLVQ------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SQQ-RTVLR-P-QLATAS-- TP-MMAVRN-QVPARIIVGQHQ-------------------------------------- ----------VQLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VP-----------LRPDGALVSKQVFAAALT-------------------PAQR- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDEAFLSCAVLQRRMLEISKRHGVTDLGTDVVTFI SHATQQRLQNLLEKVSFVAQQKNINLK-ESENYEQSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRKNLDSP--------------SSSASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGSSLMGGAGS---------------SSSRP-TRQRITR VNLRDLLFCLEDERFTSRSHFLYKGFLK-- >ENSORLP00015015894 ------------------------------------------------------------ --------------------------------MA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------STDSSAGHEPG----------------------- ----------------------ETP--DA--------GDRVTSLPNHS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVG--------------------------------------------------- -------SNSAQTFNGSQ-TMNSH--------------------------NSGSAA---- --------------------------------------------------------AVER TATSATG----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------TPAEGSG-------------------------------------------- ------------------------------------------------------------ ----------GAVL-SKGL----------LTMPA--------------SS-------GGV IQAPL------------------------------------------------------- LNSDGD---------------GVAAAAQAV------------SQAP-------------- ---------------------------GHTVTLIR-QPMQTPGSSVTLNGNNSA------ ------------------------------------------------------------ -------NSAAAAG------------------------STTDQAAVG------------- ------------------------------------------------------------ ----------------------------VQ---------------------------TNN AAP--------------------------------------------------------- ----------HIIKA----------------------------------EPPITLL---- -------------QSSPQPVL--------------------------------------- ------------------------------------------------------------ ---------------------------------------------SAPQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PPSMA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AGGLRAPNP------- -------------------------------------QM-LAPRLPQTSTGQ-P-SV--H NIQLPP---GMVLVRSESGQLLMIPQQALAQM------------------------QAQA Q------GGMAPRPSTPTNM-PL-------GQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------SLGNTI INRQ-VSP--SAISRQSCPAPTPLT-ASTTLHRPPI-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSV------- -----------------GAT-----PMAQRTLSQP------------------------- ---VGNTITT-------------------------------------------------- --------------VTVS--K--------------------------------------- --------------------------------ETLENVKKCKNFLATLIKLASSGKQSSE TAASVRELIKELLEGKVEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQHP------------QPASGP-----------VSSSSS--------------ST--- --------------------------------------VVQ------------------- ------------------------------------------------------------ -----------------------GGP--------APRLAA-------------------- ------------------------PAIKPQLQP---------------------A----- -------------TNKPG---------------------------HPTPLLVQ------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SQQ-RTMLR-P-QLAMAS-- TP-MMAVRN-QVPARIIVGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VP-----------LRPDGPLVSKQVFAAALT-------------------PAQR- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDEAFLSCAVLQRRMLEISKRHGVTDLGTDVVTFI SHATQQRLQNLLEKVSFVAQQKNINLK-ESENYEQSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRKNLDSP--------------SSSASAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGSSLMGGAGS---------------SSSRP-TRQRITR VNLRDLLFCLEDERFTSRSHFLYKGFLK-- >ENSOMEP00000021800 ------------------------------------------------------------ --------------------------------MA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SAGHEPG-KTL------------------- --------------------------DDA--------GDRVTLLPNHS------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVG--------------------------------------------------- -------SYSAQTFNGSQ-TMNSH--------------------------NAGSAAPAEG TTVTGAAGT--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------PT------------------------------------------------ ------------------------------------------------------------ -------VSSGAAL-SKGLLG--------ATVPP--------------SS-------GGV IQTPL------------------------------------------------------- LTSDG-----------------VAAAAQAA------------SQAP-------------- ---------------------------GPTVTLVR-PPMQTPGSSVTLNGNNS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ VNSADGSSTTEQAGVA-------------------------------LANNG------QP CNAGSGSAGTHIIKA----------------------------------EPPTTII---- -------------QSAPQP----------------------------------------- ------------------------------------------------------------ -----------------AGTPSVV---------------------SAPQI---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------PAMV----A-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRAPNP------- -------------------------------------QM-LAPRLPQPSPGQ-P-SV--H NIQLPA---GMVLVRSESGQLLMIPQQALAQM------------------------QAQA Q------GGMAPRPSTPTNM-PL-------GQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------SPGNTI ISRQ-VSP--TTIIRQTCPTPTPLT-ASTTLHRPPI-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSV------- -----------------GA---------PRTLSQP------------------------- ---AGTSITS-------------------------------------------------- --------------VTVS--K--------------------------------------- --------------------------------ETLENVKKCKNFLATLIKLASSGKQSSE TAASVRELIKDLLEGKVEAEEFTSRLYKELNSSPQPYLVSFLKRSLPALRQLTPDSAAFI QQSQHP------------QPASGP-----------ASSSSCSS------------ST--- --------------------------------------VVQ------------------- ------------------------------------------------------------ -----------------------GSP--------APRLAA-------------------- ------------------------PVIKPQLQP---------------------A----- -------------TNKSG---------------------------NTVPL---------- ------------------------------------------------------------ ------------------------------------L----------------------- ------------------------------------------------------------ -------V-----------------------Q---------------------------- ------------------------------------------------------------ ----------------------------------------SQQ-RTMLR-P-QVTTAT-- SS-MMAVRN-QVPARIILGQQQ-------------------------------------- ----------VQLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VP-----------LRPDGTLVSKQAFAAALT-------------------PALR- ----------------------------------------------NKLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDEAFLSCAMLQRRMLEIGRKHGVTDLGADVVTFI SHATQQRLQNLLEKVSLVAQQKNINIK-ESENYEQSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------VRGDPEHLCRPVSFTVPHFYVHVCCSDAAAGAGSDEAEGGQP HSSGSHRPQEEEEEPGLPVLLCLSRGIRNRLLPDGRGWIVGLQTHTAAHHTRQSQGPALL SGRREVYQSLPFSLQGLSEVGLTSEGGGRRHQEGKASIRFI------------------- ------------------------------------------------------------ ------------------------------ >ENSLBEP00000021454 ------------------------------------------------------------ --------------------------------MAVGFGPLGEPLVHTEVNKAVIYHNVQP VESQLL------------------------------------------------------ ------------------------------------------------------------ --FLCKNNHSSRHEKAGNYMAIVP-------------------------G---------- ------------------------------------------------------------ ---------QA--------------------------------------GR--------- ------------------------------------------------------------ -------------ASPHGSTMDASTASKDHTTGHDPG-KTLVV----------------- -------------------------------------SGGVTSLPNAR------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GEIG--------------------------------------------------- -------SYSVQTLNGNQ-TMN-------------------------------------- ----------------------------------------STGSTGNVTA---IS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------AMNSGPVM-SKGLTG--------ALMPP--------------SS-------NSV IQTPL------------------------------------------------------- MNSQS-----------------VVASPQPV------------SQAT-------------- ---------------------------GATVALVR-PPMQTVGSG-TMNGNNN------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASPAVVANATGQTGN----------NIH-----------------IPLVNNS------QP ----PVNAGSHIIKA----------------------------------EPPTTIV---- -------------QSAPQP----------------------------------------- ------------------------------------------------------------ -----------------AVTPGAV---------------------SAPRA---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------PVTV----AGS---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------AGIRALSP------- -------------------------------------QM-LAPRLPQTSPGQ-P-SIGLH NIQLPP---GMMLVRSESGQLLMIPQQALAQMQAQAQAQAQAQAQAQAQAQAQAQAQAQA Q------GGMAPRTVTPT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------SVPPELSFVFSHFSVMVIAFTLSWFVFFWQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETMENVKKCKNFLSTLIKLASTGKHSEE TAASVRELVKDLLEGRLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSTAFI QQSQLP------------QPTSAP-----------ASSTSPTP------------NT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------APRLAV-------------------- ------------------------PVSRPQLEP---------------------G----- ------------TVNKPG---------------------------QTPSM---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------NSQQ-RAMLR-P-QVTLPT-- TP-MVTVRN-QAPGRIIVGQQQ-------------------------------------- ----------VQLKGL------------------------------------------QP GKDVSLT----------------------------------------------------- ------------------------------------------------------------ -------TPL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------D-------------------------------EDDINDVASMAG VNLSEESANILATNSGLVGAVTHSCKDEAFLSCAVLQRRMLEIGRRYGLTDLGAEVVNFV SHAAQQRLQHLLEKVSQVAQQKNVHFK-EDNNYEQNSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRKILDSP--------------SSSS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSGPSVPGAAGS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSCGOP00000018779 ------------------------------------------------------------ --------------------------------MAVGTGPLGEPFSHTEVNKVIVCHPVQS VESQLS------------------------------------------------------ ------------------------------------------------------------ --FLCHNNHWGRHEADGNYMAIVP-------------------------G---------- ------------------------------------------------------------ ---------QG--------------------------------------GS--------- ------------------------------------------------------------ -------------ATPHGSTMDASTASTDSTAGHDPG-KKLVV----------------- -------------------------------------SGGVTSLSNHQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----GKVG--------------------------------------------------- -------SHSVHTFNGSH-TMNSH--------------------------NSGSAAPLGG AT-------------------------SDTRINISTATMHS------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------SS-------NSV IQTPL------------------------------------------------------- MNSQS-----------------DVASAQSV------------SPAT-------------- --------------------------TGATVTLVR-PPVQTAGSGATLNGNNN------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AS-------------------------HAAVFANTLGHTGTIGIQTPLVNNS------QP SNSVSVSAGSHIIKA----------------------------------EPPTTII---- -------------QSAPQP----------------------------------------- ------------------------------------------------------------ -----------------AVTPGAI---------------------SAPRI---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------STTV----AAS---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRALTP------- -------------------------------------QM-LAPRLHQTSPGQ-P-SI--H NIQLPP---GMVLVRSESGQLLMIPQQALAQM--------------------------QA Q------GGMAPRTATPTNV-LP-------GQ---VRSN--------------------- ----------------------KGKACCDVEHSYSQMRLEFVYNLN-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------VVC---------------------------YWQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETMENVKKCKNFLSTLIKLASSGKQSTE TAASVRELVKDLLEGRLEAEEFTSRLYKALNSSPQPYLVPFLKRSLPALRQLTPDSATFI QQSQLP------------QPASGP-----------VSSTSPIP------------TT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------APPLTT-------------------- ------------------------PVNRPQLQP---------------------G----- -------------ISKPG---------------------------QTPSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------V-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQQQ-RTMFR-P-QVALTT-- TP-MVTLRN-QAPGRIMLGQQQ-------------------------------------- ----------V------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------PVYLISFTFYCLKDLSGQINNKVSVLILKHVHVYV----------------- ------------------------------------------------------------ --------------------------------------------------------Y--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEENANILATNSGLVGAVTHSCKDEAFLPCAVLQRRMQEIGKRYGVTDLGAEVVNFV SHATRQQLQNLLGKVSQVAQQKNSTFK-EDDNYEQSSDVRAQLKFFEQLDQLEKQQKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRKILDSP---------------SSS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTGPSLSGGAGS---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSHSHFLYKGFLK-- >ENSPMGP00000017796 ------------------------------------------------------------ --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------DAATSSSDS-SGHDPG-RTLVV----------------- -------------------------------------SGGVTSLPAPQ------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----EKVD--------------------------------------------------- -------TLSVQTLNGSQ-SMNSH--------------------------NSGSAAPL-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GTAGTSVPGDSSTNTTSVNSG------------------------ -------TVLTKVL---------------------------------------------- ---------------------------------P--------------SS-------NSV IQTSP------------------------------------------------------- LNSHS--------------------------QAGGQAG----GQAA-------------- ---------------------------GATVTLVR-PPMHI----VALNGNNN------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ GSPAAVTS----TGI---------------------------SLQTPQVNNNPDP----- -SSVSVSTATNVIKQ----------------------------------EPATTII---- -------------QPPPQQ----------------------------------------- ------------------------------------------------------------ -----------------AV---------------------------SPRT---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------PVSL----SAS---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGVRTLSP------- -------------------------------------QM-LAARLPQPTSGQ-P-SV--H NIQLPP---GMVLVRSDSGQLLMIPQQTLAQM------------------------QAQA Q------GGLAPRAATPTNMQTP-------GQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------TPGNAV ISRP-VTP--STVIRPGGPVSTTLP-KTTTLHRPHI-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETMENVNKCKNFLSTLIKLASTGKQSTE TAACVRELVKDLLEGRLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQGQLP------------QSSSGP-----------ASTTS----------------T--- --------------------------------------VIL------------------- ------------------------------------------------------------ -----------------------SSP--------GPRVTT-------------------- ------------------------SITRPLLQP---------------------G----- -------------VTKPG---------------------------QSPSLVKGIH----- ------------------------------------------------------------ -----------------------------------IV----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------TPQQ-RALVR-P-QVTLPT-- AS-MVTLRN-HAPSRIMLGQQQ-------------------------------------- ----------IQLKE--------------------------------------------P GE---------------------------------------------------------- -------------RLRTNVSLDN------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------AD-------------------------------DDDINDVASMAG VNLTEESANILATNSSLVGSVTHSCEDEAFLSFALLQRRMLEIGRRHGVTDFGTDVVKLV SHATQQHLQNLLEKVTQVAQQKNISFK-DNDNYDQSSDVRAQLKFFEQLDQLEKQRMEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKFKEMQQQELAQM RQREANLTALAAIGPRKKRKIGDFS--------------SSSSVSE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGTASSASGGASA---------------SGSRP-TRQRITR VNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSHCOP00000019483 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MNCH--------------------------TSGSVVP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------PV-----------------------GK-TVAS-CHNSCQVTSVSSTGQVL PKASSAATVV-------------------------------------------------- ---------------------------------P--------------LS-------NTV IHTPL------------------------------------------------------- PNPQT-----------------VIAS---------------------------------- ---------------------------APTVTLVR-PPMQTVQLGPTLNGNGD------- ------------------------------------------------------------ -------------GMRALAPPIKPQTSATNMPAASHQSGTSDGA---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------PP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAS---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGMQTLTQ------- -------------------------------------QI-LSPRLPLTSTGQ-P-GI--H NIQLPP---GMVLVRSEAGQLLMIPQQALAQM------------------------QAQA L------GGAASRTAAP-NM-TP-------GQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------VPGNAV ISRQ-TSP--SAIIRQGCPTPASLP-STTALHRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSV------- -----------------GTAI---PGMAQR--SQT------------------------- ---AGATVTS-------------------------------------------------- --------------VTMS--K--------------------------------------- --------------------------------ETMENVNKCRNFLSTLIKLTCTGKRFSE -AASVKQLVKDLLENKLEAEEFTSRLYKELNSSPQPYLVPFLEKNLPALRQLTPDSAAFI RQSQLA------------QPASAS-----------VSSTSASP------------AA--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------GSP--------APRLSA-------------------- ------------------------QIHRPQLQP---------------------N----- -------------VSKPG---------------------------HTTSL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------QQP-RAALR-P-QVPLAV-- SS-VVNLRN-QAPGRVVLGQPQ-------------------------------------- ----------VQLKEL------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FP-----------VKSEVSAVSRQNSAAVLT-------------------LAQK- ----------------------------------------------DRLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESANILATNSGLVGAVTRSCKDEAFLSCAMLQRRMLEIGRRHGVTDLGPEVINYV SHATQQRLRDLLERVSLVAQQKNGNFK-EEDNHEQSSDVRSQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANQTALAAIGPRKKRKILDSP--------------SSTAATE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GSGPNLSGGAGS---------------AGSRP-TRQRITR VNLRDLLFCLENERCTSSASFLYKGFLK-- >ENSGMOP00000018451 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TQ------- -------------------------------------QL-LAPRLPQTPAGQ-P-NL--Q NFQLPP---GMVLVRSESGQLLMIHQQALAQM------------------------QAQA Q----------PRPATPTAM-PL-------AQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGIPM SSRP-MGP--GSMVRQASP----VA-PTTTLHRPPV-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------VL--L--------------------------------------- --------------------------------ETMENVKKCRNFLSTLIKLASTGKQSAQ TAENVKELVKELLEGKLEAEDFTSKLYSELNSSPQPYLVPFLKRSLPALRQLTPNAALFA QQSHVP------------QPT---------------ASTPPSP------------AT--- --------------------------------------VVL------------------- ------------------------------------------------------------ -----------------------RSP--------APHLTT-------------------- ------------------------AVTRPQVQP---------------------D----- -------------ISRPG------------------------------------------ ------------------------------------------------------------ ------------------------------------L----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------PQPL-AVGMR-P-PVNMAT-- AP-MVTPRT-QSPGKILVGPQQ-------------------------------------- -------------------------LRQLPQVVLGRTGLLP---------------VFKP ------------------------------------------------------------ ----------------------------------------------VP------------ ---------------------------------------------P-------------- --------------------------------AAAS-------------------LAQK- ----------------------------------------------NQLKEA-GGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------EDDINDVASMAG VNLTEESARILATNSELVGAVTRSCKDEAFLSTAVLQRRMLEIGKKFGVSELGVDVGTFV SHATQQRLQNLLEKVTQVAQHKNFSFK-EESSYEGSSDVRAQLRFFEQLDQLEKQRKEGQ ERQILLKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAMM RQKEANLTALAAIGPRKPRKPADAS--------------ASAGAAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSGSSL--GAGS---------------SGSRP-TRQRITR INLKDLLFCLETERPTAHSQFLYKGFL--- >ENSPNAP00000027332 ------------------------------------------------------------ --------------------------------MAAGPELLDDVFFNAEVDEKTVSDVVGS LESQLIGAG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------PGKLAGRLQTAG GHIG-------------------------------------------------------- -------------------------------------------------GSAGGNSGEIR DNNNMGLGQENQRAGARMPAGSINDARVPPKGMDARAA-----------------T---- -----------------------------------PG------------NLKPGLG---- ------------------------------------------------------------ -------------------------------------------------------ATSAA S----------------------------------------------------------- ----------------------------IANHMLGS------------------------ ------------------------------------------------------------ -----GQRG--------------------------------------------------- -------TSAVTSLNGSNVLVNSH------------------------------------ ---------------GSVGVGPFSSASS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------APSPVSG------------------------------------IVSTG--- ------------------------------------------------------------ -----TVVNNGPG---------CMPKGQ----TT--------------PS-------GTV IQTSL------------------------------------------------------- MN-----TAT-------------VISAQT------------------------------- ----------------------SCLSAGPTVALVR-PPMQT------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------QVTVTAPNGTGSLALSAGVNAVHLPTSHT-- ------------------------------------------------------PG---- --SLSLSSAGQVNKA----------------------------------DSTKTLI---- -------------QTVAQT----------------------------------------- ------------------PVSVAQP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------IRGPV-------------MQS------------------------------ -------GSRTPVPAAV----GAN---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGIRAIAP------- -------------------------------------QV-LAPRVPQPQQSQ-P-SV--H NIQLPP---GMVLVRSESGQLLMIHQQTLAQM------------------------QAQS Q------GAMATRPTTPTST-PPV--HITSVQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTSL ITRQ-VAP--TTIIKQASPVPAPVQ-PTTALQRPPL-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------NNIMLGGTTA PP-----------------------------------VGTPP---PGQVGVAPTQRVTTV GP------TP-------------------------------------------------- --------------APAT--T--------------------------------------- --------------------------------ETLENVKKCKNFLSTLIKLASSGKQSSE TAANVKELVKNLLEGKLEAEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDSVAFI QQSQLQ------------QPS--------------APTSSTAL------------TA--- --------------------------------------AVLGGSSTVR------PT---- -----------------------------SLP---------------------------- -------------------------------------------------------TTPSA AIAKTSSTASITSATTPTTTSPH--------QP--------------VISLSQ------- -----------NAPSKPNL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------IV----------------------Q---------------------------- ------------------------------------------------------------ ------------------------P--------------PQQQLGTLVRGP-QVNLAQ-- TP-MVTLR---------------------------------------------------- -----------------------------------------------------------P GQ--------------ARVLSPQTVVKTQT------------------------------ ------------------------------------------------------------ --------------------------------------------LPSGSMVKTAVSVGNK LLS----------------------------------VSG---------PQSLPSAVQK- ----------------------------------------------TKLKDAGSGSF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESDRILATNSELVGVVTRSCKDEPFLYTGSLQRRILEIGKKYGITEVGSDVISIV SHAAQQRLQNLLEKVTQVAQQKNVPYK-EDERHEQISDVRAQLKFFDQLDQMEKQKKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQM RQRDANLTALAAIGPRKKRK-MDTS--------------AGGSGPE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GVSSVSAGSVAAGS---------------GGSRQFPRQRITR VNLRDLLFCLENERETSHSHLLYKAFLK-- >ENSAMXP00000002973 ------------------------------------------------------------ --------------------------------MAAGSELLDDVFFSAEVDETAVSAVVGS LESQLIGPG--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------VGKLAGRLQTPG G----------------------------------------------------------- ------------------------------------------------------------ -----------QR----------------------RAAAGDNMPAGARLQSIGAGT---- -----------------------------------PG------------HLKQGLGPAPT LNHTPVSGQRAAPTGAPIGAP-------------------------------TGAT---- ---------------------LNGSNMVMVVNSHDSAAFSNTSSSPAPVPPTPGAA---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------VNNGPG---------CVLKAP----PP--------------PS-------GTV IQTSL------------------------------------------------------- MN-----TST-------------VISAQT------------------------------- ----------------------PGLTTRPTVALVR-PPMQT------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------QVTVAPPNG-------AAVNAVHLPTT---- ------------------------------------------------------------ -------------------------------------------------------ITV-- -AQSHRVDSPKALQTVAQA----------------------------------------- ------------------PTTVVQP----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------IRGPI-------------MQT------------------------------ -------GGRTTVPGAV----AAG---A-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GAIRAIAP------- -------------------------------------QV-LAPRVPPPQQNQ-P-SV--H NIQLPP---GMVLVRSESGQLLMIHQQTLAQM------------------------QAQT Q------GAMAPRPTTPTST-PPV--HITSVQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTPL ITRP-VAP--TTIIKQSSPVPAGVQ-PTTALQRPPI-------L---------------- ---Q-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------ETLENVKKCKNFLSTLIKLASSGKQSSE TAANVKELVKNLLEGKLEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSVLFI QQSQ-------------------------------------------------------- ------------------------------------------------------------ ------------------------------LPLGPP-----PTATP-------------- -------------------------P--------SPALTSAVLTTSITSTTSSTLTTP-- ------------------TTSAH--------QP--------------IASLPQ------- -----------HTHSKPNL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------V---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TF--- ---------------------SNSYRYTLQQGAISPTPSVNTCNHACLLVLC-------- ------------------------------------------------------------ ---VI------------------------------------------------------- -------------ICRD-------------------------------DDDINDVASMAG VNLSEESDRILATNSELVGAVTRSCKDEAFLYTGALHSRILQIGKKFGISELGSDVVSIV SHAAQQRLQNLLEKVTQVAQQRNVPYK-EDERHEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQM RQRDANLTALAAIGPRKKRK-VDSP--------------ASGSGPEV------------- ------------------------------------------------------------ ------LKGCVLLVLVGCAR---------------------------------------- -------------------------------------W---------------------- ------------------------------------------------------------ ------------------------------GS---------------GGSRQFSRQRITR VNLRDLLFCLENERDTSRSHLLYKAFLK-- >ENSDARP00000103064 ------------------------------------------------------------ --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VTTL---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------IG--------------------------------------------------- -------TSTVQTLNGGN-AMDPH----------T---------------ESG------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TPV------------------------------------------------ -----------------SSGP------SSSSSDDASTS---------------------- ----VPVVNNGPGV-AKGLGN--------VTVAP--------------SP-------NTV IQSSF------------------------------------------------------- ---------------GTPPA---------------------------------------- ------------AAS----------SAGPLVTVVR-PSMQTAGAGLTINGSNN------- ------------------------------------------------------------ ----------------------------------------------NTTISVANVATPGI TTTSTTTTSSTTTTTPLLLNQTSAPVTAS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------KS----------------------------------ESPKTII---- -------------Q---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------PAGSMTVG PAVAKGAVLQGVARTAAPATVAAASASSSPTIRASAPQV-LAPRLPQSSPGQ---NI--Q NIQLPP---GMVLVRSDSGQLLMIPQQMLAQL------------------------QAQT QSA---------RPAAPAST-TPA--QITPAQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTPL MARQ-VTP--TTIIKQGSHTASS-T-ATTTLQRPPV-------Q---------------- ---QA------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------SSV------- -----------------GPVLSVQAGAAQRTVTAA------------------------- ---TGTT----------------------------------------------------- --------------VSSA--T--------------------------------------- --------------------------------ETMENVKKCRNFLSTLIKLATSGKQSSE TVANVKELVKNLLEGKIEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSTAFI QQSQAL------------H----------------------------------------- ----------------------------------SPT-VVL------------------- ------------------------------------------------------------ -----------------------TSPNTAGGTTAAPR----------------TLT---- -------------------------------QP---------------------A----- ------------------------LSNSS----------------QTASL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------SPQQ-GAIVKPP-QVTLTT-- TP-MVTLRG-QPHSHIVVGQPQ-------------------------------------- ----------LQLKQI-------------------------------------------- ----------------------------QT---------V-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------PLKQGVMASTKLVH----------SSVNLV-------------------AAQK- ----------------------------------------------NKPKDGAGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------RD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGAVTRSCKDEAFLSASMLQHKILEIGQRFGVTDLGPEVVNIV SHATQQRLQNLLEKVSLIAQQKNMTYK-EDSRYEQVEDVRAQLKFFEQLDQLEKQKKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQRDANLTALAAIGPRKKRK-PDSP--------------SLGIDTE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGLCASASGGLNA---------------GASRQFTRQRITR VNLRDLLFCLENEKSTSHSQLLYRALLK-- >ENSIPUP00000035460 ------------------------------------------------------------ --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VTTLPGHE------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VKLG--------------------------------------------------- -------TSTVQTLDGGD-AMDPR----------S---------------ES-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TPA------------------------------------------------ -----------------SSG---------------SSSDTTASAPVNV------------ ---TVPVVNNGPGI-AKGL----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VTASSTSNTVIQASFVNAPSAPGGTATATIRSSMQ PATLTINGNNSNASCVLTAAPLTHAQPPVNVS---------------------------- VSPAV-------------------------------------------------P----- ------------IKA----------------------------------ESPQTVI---- -------------QSAAHT--------GS------------------------------- ------------------------P----------------------------------- -----------------QVSPGAAKGAGLMHATTAVRGGAPVTGGGAPVT---------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------AAA---A-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------GGVRTIAPQ------ -------------------------------------QV-LAPRLPQSTPGH-P-SI--H NIQLPP---GMVLVRSEAGQLLMIPQQVL----------------------------AHM QAT---------RAATPAST-TPG--QVTSTQ---------------------------H VTD---------------------------------------------GSFLLERVTERE RESEKETEGERERDRQTEKETEREGERETESERERVRGREEMQSSYWLNHDHAGTPGATI MARP-VTP--TTIIKQGSPTTSS-T-TAPTLQRPPV------------------------ ---QP------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------ASV------- -----------------GSVLAVQPGTAQRMVTPT------------------------- ---TGTS----------------------------------------------------- --------------VTLA--T--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLATSAKQSSQ TAANVKDLVKNLLEGTIEAEDFTSRLYKELNSSPQPYLVPFLKRSLPALRKLTPDSLAFI QQSQGL------------QP------------------------TRPAATVVLTNTTTAN AATVATATPAASVPSATPSISAGTAATIASAAVAT------------------------- ------------------------------------------------------------ ----------------------------------APR----------------TLT---- -------------------------------QP---------------------S----- ------------------------LATTS----------------QPASL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------SQQQ-GAIVKSP-QVTL-A-- TP-MVTLRG-QPHSRIVVGQPQ-------------------------------------- ----------VQVKQL-------------------------------------------- ----------------------------NT---------V--------------AVKPGM VSGAKV------------------------------------------------------ --------------------------------------------SP-------------- -----SP-------------------------VAFN-------------------AAQK- ----------------------------------------------NKLKDASGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KD-------------------------------DDDINDVASMAG VNLSEESARILATNSELVGAVTRSCKDEAFLFSAALQRRILDIGKRFGVTDLGPEVVNLV SHATQQRLQNLLEKVTVIAQQKNMNYK-EDARFEQMTDVRAQLKFFEQLDQLEKQKKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQRDANLTALAAIGPRKKRK-LDSP--------------ALGTDAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSSASSSAGLSG---------------GASRQFTRQRITR VNLRDLLFCLENEKESTRSQLLYRALLK-- >ENSPNAP00000027322 ------------------------------------------------------------ --------------------------------M--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VTTLPSHE------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VKTG--------------------------------------------------- -------TSTAQTFGGGD-AMDAR----------A---------------ESGAALP--- ------------------------------------------------------------ ------GTPVSNSSPAADASAGMVLNNGPGVVVTKGPASGSGGGAPSTSGTVIIQTSTAT GATVTVVRPAMQTTTNAMVHTVNG-------SNVNSTAVLNVAQQAPTAAAPATGVTLTI TPQTSGQAPAPGVLTTKPEPAKSIIQSPAGHTATVTLAQQLQPQLHVSPGPAKGAVLQQG VARSAAPAPSPA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GVRAIAPQ------ -------------------------------------QV-LAPRLPQSSPGQ-H-SI--Q NIQLPP----MVLVRSESGQLLMIPQQVLAQM------------------------QAQM QAT---------RAVTPAST-TPG--QITSAQ---------------------------- ------------------------------------------------------------ ----------------------------------------------------LQTPGAPI MTRQ-VAP--T-IIKQGPPTASS-T-ATTTLQRPPV------------------------ ---QL------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------PSV------- -----------------GSVLAVQPGAAPRVVTPA------------------------- ---TGTS----------------------------------------------------- --------------VTLA--T--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLATSAKQSSQ TAANVKELVKNLLEGTIEAEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSLAFI QQSQGL------------Q-------------------------AKPAATVALTSSTQ-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------Q---------------------------- ------------------------------------------------------------ ---------------------------------------SPQQ-GAIVKTP-QVTLTT-- TP-MVTLRG-QPHSRIVVGQHH-------------------------------------- ----------MQVKQL-------------------------------------------- ----------------------------QT------------------------TVKPGA VPGAKL------------------------------------------------------ --------------------------------------------SP-------------- -----SP-------------------------VTLI-------------------AAQK- ----------------------------------------------SKLKDAAGGTF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------D-------------------------------DDDINDVASMAG VNLSEESARILATNSDVVGAVTRSCQDEAFLSSALLQRRILDI-KRFGVTDLAPDVVNLV SHATKQRLQNLMEKVSVIAQQKNMTYK-EDGRFEQVTDVRAQLKFFEQLDQLEKQKKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAKEMQQQELAQI RQRDANLTALAAIGPRKKRK-LDSP--------------ALGTDAE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSGSSASMTVGLSG---------------GVSRQFTRQRITR VNLRDLLFCLENERASSRSQLLYRALLK-- >ENSCHAP00000056366 ------------------------------------------------------------ --------------------------------MAVDPELLDAVLSNTEVDHKVVSIIVGS LDWEIRQTG--------------------------------------------------- -----------------------------------------------------------Q -------------------------------------------------G---------- ------------------------------------------------------------ -------------------------------------TFVSRVVAYDITGS--------- ------------------------------------------------------------ --------GVAL------------------------------------------------ ----------------------------------------------------AGTP---- ------------------------------------------------------------ ------LS---------------------------------------------------- ------------------------------------------------------------ ---------------------------------GGPNV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------NITSNPVVS----- ------------------------------------------------------------ ----------------------NGLGMADGNTNVNV------------------------ ------------------------------------------------------------ ---------IPS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------SP-------NIV IRT--------A------------------------------------------------ TNSQNTVLSP-------------------------------------------------- ----------------------SL-GSGATSVTIR-PPVQMGTSG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------AISNVTTT--TQIVTASQG------------------------ --------TLQNPL-------------LQT------------------------------ -------VTRTVSPTAV----AAAV--PSNMN---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QSGVRAIAP------- -------------------------------------QV-FAPRLPQPGPNP-PANV--Q NIQLPP---GMVLVRNQSGQLLMMHQQTLAQM------------------------QAQA KSQ----SAMAPRPSTPTIS-TP-------IK---------------------------- ------------------------------------------------------------ ------------------------------------------------------APGTPI VARH-MAP--LTVTKQGSPTPVSAP-ATTTLQRPPI-------L---------------- ---Q---------------------------------VH--------------HSTSGIF PRIWTKEYPLLN------------------------------------------------ ------------AQC---------------------------FY---------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------T--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLACSGKQSTE TAANVKDLVRKLLEGKIEPEDFTGRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQGL-----TP-----SPAT---VTPAIAGPFPVTATATAA--------ALGATAN-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------LTAP---------------------------------- ---------------------------RPRLQP--------------------------- -----------------------------------------------TTL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------R---------------------------- ------------------------------------------------------------ ---------------------------------------APQP-GAIRKPP-HVTMAT-- TP-MVTLRT-QPQNRVFVGAPS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -K---------------------------------------------------------- ------------------------------------------------------------ -----------------MI--------------------------------TGAGVG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GD-------------------------------DDDINDVASMAG VNLSEESARILAINSDLAGTVMRSCKDEAFLHTPMLTRRIAEIGKKYGIAELGPELVTFV SHATQQRLSSLLEKASVVAQHKNANFK-EGNHYEQASDVRLQLKFFEQLDQMEKQRKEEQ EREILMKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAEI RQREANLTALAAIGPRKRKK-MDSPG---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------SSGASCSSSASSGS---------------GASRQFTRQRITR INLRDLLYCLENEHSSSHSQLLYRGLLK-- >ENSDCDP00000038070 ------------------------------------------------------------ --------------------------------MK-------------------------- -------------------------------------------------TQSSAVD---- ------------------------------------------------------------ -------------------------------------------------GR--------- -----------------------------------------------------AAEETSV IQQNLVKQPEG--------------------------------------GVAG------- ------------------------------------------------------------ ----------------------------------DPG----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PRTWNGDESKCQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------TPV-----------------------G------------------------ ------------------------------------------------------------ -----------------------------AAAPPVPAFQNSAASAPATTSAA-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------VAVAR-APFQAAG----------------- ------------------------------------------------------------ ---CA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ AAP---------------------------------G----------------------- ---------------------------------------------------PTTVT-VSG GAAAH-------VQTGPRPAC--------------------------------------- ------------------------------------------------------------ ---------------------------------------------SSP------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AAAA---P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------AAVRTMTP------- -------------------------------------QVALTPRLPQPAPSQ-P-SI--S NIQLPP---GMVLVRSETGQLLMMPQQVLAQL------------------------QAKS Q------NAIAPRPANPIST--------ATVK---------------------------- ------------------------------------------------------------ ------------------------------------------------------APSSPI VPRQSVTP--VAIAKQGAITASSMS-ATPTTHRPPV-------L---------------- ---Q------------------------GPRPATA------------------------- ------------------------------------------------------------ --VSSSQ----------------------------------------------------- -----------------GTSV--QPGVPQRTLVAS------------------------- ---TG------------------------------------------------------- --------------TTVS--Q--------------------------------------- --------------------------------ETMENVKKCKNFLSTLIKLASSGKQSSE TAANVKELVKKLLEGRVEAEDFTSSLYKELNSPPQPYLVPFLKRSLPAVRQLTPDSMAFI QQSLTP------------AQPQKP-----------TASVST------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------P---------------------------------- ---------------------------RTQAQP--------------------------- -----------------------------------------------TTL---------- ------------------------------------------------------------ ------------------------------------V----------------------- ------------------------------------------------------------ -------L-----------------------K---------------------------- ------------------------------------------------------------ ---------------------------------------TSQQ-GTVLKAP-QVT-GT-- TP-LVTLRS-QPPSRVVLGPQA-------------------------------------- -------------------------LA-------------------------------KP ------------------------------------------------------------ -----------------------------------------LM----------------- --------------------------------------------AP-------------- -----KP----------------------------------------------------- ---------------------------------------NDGEGT--------GGSF--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------R--------------------------------DDDINDVASMAG VNLSEESARILATNSDVVGAVTRSCGDKAFLYSTALQRRILEIGRRKGITELGPDVVNFV SHAAQHRLRDILERVSTIAHHKNVAFK-EDGKHEQTDDVRLQLKFFEQLDHVEKQRKEEQ EREILMKAAK----------------------SRARQEDPEQLRLKQKAKEMQQQELAQM RQREANLTALAAIGPRKKRK-VDSL--------------GGGAGTE-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GSLSTSLSVSGAGT---------------GPARQFTRQRITR VNLRDLLVCLENERSTCHSQLLYRALLK--