>ENSMMOP00000022784 -------------------------------------------------- ------------------------------------------MAAGSYSL ADVFFNTEVDEKVVSDLVGSVESELSAAGRANTTAGGQSAANHVGSCAVG ----SNS------------------------------------------- SVQSSKMGLSQQELAKAxxxxxxx-------------------------- ---------------------------------------G---------- ------------------IDARRGLINCT--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xASS MDGA---------------------------------------------- ------------------------------------------AGTT---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxGKTG- -------------------------------------------------- -------TAGAQTLNGSTVLVNCHxxxxxxx------xxxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------VNNGPV---------xVxxxxxx xLSA--------------TP-------GAIIRTPx--------------- ----------------------------------------TSAQNT---- -------------xxxxxx------------------------------- ----------------------xx-xxVPTVTLVR-APMQTPS------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxx--xxxxxxxxxxxxxxx xxxxxxxxxDATKAVI-----------------QTGG------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxx--------xxRSPx-------------------------- ----------------------xxxx--LRTSATSTV----Gxx--xA-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------AGVRT VTQ--------------------------------------------QV- LAPRLSQx-------NI--QNIQLPP---GMVLVRSESGQLLMIHQQTLA QM------------------------QAQSQSx----SAMTPRPAAPTST -PPV--QITTLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGASLLTRT-VTP--TTIIKQGSTVHTTVT-ATTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxx------------------------------ ------xxxxxxxxxxxxxxxxxxxxxxxxxxx-------x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTANVKELVK KLLEAKIEPEDFTSNLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QTSTPT-----------AAAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------PPHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxx----------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------x -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESDRILATNSELVGT VTRSCKDETFLSTSLLGRRALEIGKKFGVSELGTDVINYISHATQQRLQN LLEKVSQVAQLKNQSFK-EDERYEQVGDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------V RGAS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSGPSQPGGSSG-------- -------AGCRQFMRQRITRVNLRDLLFCLETERGTSHSQLLYRGFLK-- >ENSPREP00000011437 -------------------------------------------------- ------------------------------------------MAAGSDLL ADVFSNRAVDKKVVSEVV-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxx--------------xxx----xxxxxxxxxxxxx----xxxxxx-- -------xxxx--------------------------------------- ----------------------------------------------xGRS MEGT---------------------------------------------- ------------------------------------------xGIT---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------LDGNGAVMNCHxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxxxx----------------xSAQNPSTSS -------------GSSSQP------------------------------- ----------------------Ax-xxVPTVALVRxPPMQTSA------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xxxxxxxxxxGVx---xxxxRNPx-------------------------- ----------------------xxxx--MRTTLSSTI----Sxx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------AGIRT IAP--------------------------------------------QV- LAPRLTQPQQNA-T-SI--QNIQIP---xGMVLVRSESGQLLMIHQQTLA QM------------------------QAQAQSx----SATTPRPAAPTST -PPV--QVTSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----TPGGPLLARS-VTP--TTIIKQGSPVQTTVA-TTTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxx------ -------x------xx---------------------xxxxxxxx----- ----------xxETLENVKKCGNFLSTLIKLASNGKQSSETTATVKELVK NLLEGKMEPEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDPEAFI QQSLLP------------QSSGQS-----------AAATSPAL------- -----GA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVITLSQ------- -----------KANSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxx---------------------------xxxxxxxxxxxxxxxxxx xxxxxxxxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxx-VQx---------------------------------------- -------------------------------------------------- -------------------------------------------------L xxxxLV-------------------DAQR--------------------- --------------------------NRLREAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEENARIMASSSELVGI VTRSCKDEAFLSISPLTRIVLQIGKKFGVSELGTDVINYISHATQQRLQN LLENASQVAQLKNLNFK-EEERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQLELAQIRQREANLTALAAIGPRKKRR-TDSP--------------L SGAS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGLGSTQPGGSSG-------- -------QGSRQFMRHRITRVNLRDLLLCLENDRDSSHSQLLYKGLLK-- >ENSGAFP00000020284 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------MVLVRSESGQLLMIHQQTLA QM------------------------QAQAQSx----SATTPRPAAPTST -PPV--QVTSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----TPGGPLLARS-VTP--TTIIKQGSPVQTTIA-TTTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxx------ -------x------xx---------------------xxxxxxxx----- ----------xxETLENVKKCGNFLSTLIKLASSGKQSSETTATVKELVR NLLEGKIEPEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDPEAFI QQSLLP------------QPSGQP-----------AAATSPAL------- -----GA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVITLSQ------- -----------KANSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-VQx---------------------------------------- -------------------------------------------------- -------------------------------------------------L xxxxLI-------------------DAQR--------------------- --------------------------NKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEENARIMASSSELVGI VTRSCKDEAFLSIPSLTRIVLQIGKKFGVSELGTDVITYISHATQQRLQN LLENASHVAQLKNLNFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQLELAQIRQREANLTALAAIGPRKKRR-TDSP--------------L SGASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGLGSSQPGGSSG-------- -------QGSRQFMRQRITRVNLRDLLLCLENDRDSNHSQLLYKGLLK-- >ENSXMAP00000026305 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxGT---------------------------------------------- ------------------------------------------xGIT---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------LDGNGAVMNCHxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxxxx----------------xSAQNTSTSS -------------GSSSQP------------------------------- ----------------------Ax-xxVPTVALVR-PPMQTSA------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxGVx---xAxxRNPx-------------------------- ----------------------xxxx--LRTTLSSTI----Sxx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRS IAP--------------------------------------------QV- LAPRLTQPQQNA-T-SI--QNIQIP---xGMVLVRSESGQLLMIHQQTLA QM------------------------QAQAQSx----SATTPRPAAPPST -PPV--QVTSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----TPGGPLLARS-VTP--TTIIKQGSPVQTTVA-TTTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx xxxxx--------------------------------xxxxxxxx---xx xxxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxIT--x--------- -------------------------------------------------- ------------ETLENVKKCGNFLSTLIKLASNGKQSSETTATVKELVR NLLEGKIEPEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDPEAFI QQSLLP------------QPSSQP-----------AAATSPAL------- -----GA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVITLSQ------- -----------KANSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------A xxx----xx-x-xxxxxx--xx-xxxxxx-AAPSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-VQx---------------------------------------- -------------------------------------------------- -------------------------------------------------L xxxxLV-------------------DAQR--------------------- --------------------------NKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEENARIMASSSELVGI VTRSCKDEAFLSISSLTRIVLQIGKKFGVSELGTDVINYISHATQQRLQN LLESASQVAQLKNLNFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQLELAQIRQREANLTALAAIGPRKKRR-TDSP--------------L S-ASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGLGSSQPGGSSG-------- -------QGSRQFMRQRITRVNLRDLLLCLENDRDSSHSQLLYKGLLK-- >ENSPLAP00000021753 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxGT---------------------------------------------- ------------------------------------------xGIT---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------LDGNGAVMNCHxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxxxx----------------xSAQNPSTSS -------------GSSSQP------------------------------- ----------------------Ax-xxVPTVALVRxPPMQTSA------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxGVx---xAxxRNPx-------------------------- ----------------------xxxx--MRTTLSSTI----Sxx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRT IAP--------------------------------------------QV- LAPRLTQPQQNA-T-SI--QNIQIP---xGMVLVRSESGQLLMIHQQTLA QM------------------------QAQAQSx----SATTPRPAAPTST -PPV--QVASLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----TPGGPLLARS-VTP--TTIIKQGSPVQTTVA-TTATLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx xxxxx--------------------------------xxxxxxxx---xx xxxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxIT--x--------- -------------------------------------------------- ------------ETLENVKKCGNFLSTLIKLASNGKQSSETTATVKELVK NLLEGKMEPEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDPEAFI QQSLLP------------QPSGQP-----------AAATSPAL------- -----GA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVITLSQ------- -----------KANSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------T xxx---xxx-x-xxxxxx--xx-xxxxxx-xAPSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-VQx---------------------------------------- -------------------------------------------------- -------------------------------------------------L xxxxLV-------------------DAQR--------------------- --------------------------NKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVTSMAGVNLSEENARIMASSSELVGI VTRSCKDEAFLSISSLTRIVLQIGKKFGVSELGTDVINYISHATQQRLQN LLENASQVAQLKNFNFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQLELAQIRQREANLTALAAIGPRKKRR-TDSP--------------L SGASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGLGSSQPGGSSG-------- -------QGSRQFMRQRITRVNLRDLLLCLENDRDSSHSELLYKGLLK-- >ENSPMEP00000034021 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxGT---------------------------------------------- ------------------------------------------xGIT---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------SDGNGAVMNCHxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxxxx----------------xSAQNPSTSS -------------GSSSQP------------------------------- ----------------------Ax-xxVPTVALVRxPPMQTSA------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxGVx---xAxxRNPx-------------------------- ----------------------xxxx--MRTTLSSTI----Sxx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRT IAP--------------------------------------------QV- LAPRLTQPQQNA-T-SI--QNIQIP---xGMVLVRSESGQLLMIHQQTLA QM------------------------QAQAQSx----SATTPRPAAPTST -PPV--QVASLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----TPGGPLLARS-VTP--TTIIKQGSPVQTTVA-TTATLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx xxxxx--------------------------------xxxxxxxx---xx xxxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxIT--x--------- -------------------------------------------------- ------------ETLENVKKCGNFLSTLIKLASNGKQSSETTATVKELVK NLLEGKMEPEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDPEAFI QQSLLP------------QPSSQP-----------AAATSPAL------- -----GA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVITLSQ------- -----------KANSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------T xxx---xxx-x-xxxxxx--xx-xxxxxx-AAPSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-VQx---------------------------------------- -------------------------------------------------- -------------------------------------------------L xxxxLV-------------------DAQR--------------------- --------------------------NKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVTSMAGVNLSEENARIMASSSELVGI VTRSCKDEAFLSISSLTRIVLQIGKKFGVSELGTDVINYISHATQQRLQN LLENASQVAQLKNFHFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQLELAQIRQREANLTALAAIGPRKKRR-TDSP--------------L SGASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGLGSSQPGGSSG-------- -------QGSRQFMRQRITRVNLRDLLLCLENDRDSSHSQLLYKGLLK-- >ENSPFOP00000010203 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxGT---------------------------------------------- ------------------------------------------xGIT---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------SDGNGAVMNCHxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxxxx----------------xSAQNPSTSS -------------GSSSQP------------------------------- ----------------------Ax-xxVPTVALVRxPPVQTSA------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxGVx---xAxxRNPx-------------------------- ----------------------xxxx--MRTTLSSTI----Sxx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRT IAP--------------------------------------------QV- LAPRLTQPQQNA-T-SI--QNIQIP---xGMVLVRSESGQLLMIHQQTLA QM------------------------QAQAQSx----SATTPRPAAPTST -PPV--QVASLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----TPGGPLLARS-VTP--TTIIKQGSPVQTTVA-TTATLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx xxxxx--------------------------------xxxxxxxx---xx xxxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxIT--x--------- -------------------------------------------------- ------------ETLENVKKCGNFLSTLIKLASNGKQSSETTATVKELVK NLLEGKMEPEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDPEAFI QQSLLP------------QPSSQP-----------AAATSPAL------- -----GA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVITLSQ------- -----------KANSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------T xxx---xxx-x-xxxxxx--xx-xxxxxx-AAPSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-VQx---------------------------------------- -------------------------------------------------- -------------------------------------------------L xxxxLV-------------------DAQR--------------------- --------------------------NKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVTSMAGVNLSEENARIMASSSELVGI VTRSCKDEAFLSISSLTRIVLQIGKKFGVSELGTDVINYISHATQQRLQN LLENASQVAQLKNFNFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQLELAQIRQREANLTALAAIGPRKKRR-TDSP--------------L SGASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGLGSSQPGGSSG-------- -------QGSRQFMRQRITRVNLRDLLLCLENDRDSSHSQLLYKGLLK-- >ENSXCOP00000015076 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------MVLVRSESGQLLMIHQQTLA QM------------------------QAQAQSx----SATTPRPAAPPST -PPV--QVTSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----TPGGPLLARS-VTP--TTIIKQGSPVQTTVA-TTTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxx---------------------------xxxxxxxxx---xx xxxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxx------------- -------------------------------------------------- -----------xETLENVKKCGNFLSTLIKLASNGKQSSETTATVKELVR NLLEGKIEPEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDPEAFI HQSLLS------------QPSSQP-----------AAATSPAL------- -----GA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxx-VQx---------------------------------------- -------------------------------------------------- -------------------------------------------------L xxxxLV-------------------DAQR--------------------- --------------------------NKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEENARIMASSSELVGI VTRSCKDEAFLSISSLTRIVLQIGKKFGVSELGTDVINYISHATQQRLQN LLENASQVAQLKNLNFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQLELAQIRQREANLTALAAIGPRKKRR-TDSP--------------L S-ASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGLGSSQPGGSSG-------- -------QGSRQFMRQRITRVNLRDLLLCLENDRDSSHSQLLYQGLLK-- >ENSCVAP00000010278 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxGMVLVRSESGQLLMIHQQTLA QM------------------------QAQAQSx----SAITPRPVAPSTT -PSV--QVT----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxx--------------- ------xx------------------------------------------ -------------------------------------------------- ---------------------------------------xxxxxxxxxxx xxxxx--------------------------------xxxxxxxx---xx xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASNGKQSSETTASVKELVK SLLEGRIEPDDFTKQLYKELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QPSTQP-----------AAAASTAL------- -----GA-----------------------------------------VV L------------------------------------------------- ---xxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxx----xxNKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESARIMATSSELVGI VTRSCKDEAFLSISSLTRIVLQIGKRFGVSELGTDVISYISHATQQRLQN LLEKASHVAQQKNINFR-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQLELAQIRQREANLTALAAIGPRKKRK-TDSP--------------L SGASx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------SGSGPTQPGGSNG-------- -------PGSRQFMRQRITRVNLRDLLLCLENDRETSHSQLLYKGLLK-- >ENSFHEP00000002580 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xDGT---------------------------------------------- ------------------------------------------xGIP---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------LDGSGALANCHxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxxxx----------------xSAQNTSTSP -------------GSASQP------------------------------- ----------------------Sx-xxVPTVALVR-PPMQTSx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxGVLxGTxAxxRSPx-------------------------- ----------------------xxxx--LRASLPSAV----Gxx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRT IAP--------------------------------------------QV- LAPRLTQPHQNP-T-SI--QNIQLPP---GMVLVRSESGQLLMIHQQTLA QM------------------------QAQAQSx----SAITPRPVAPTGT -PPV--QVTSAQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----TPGAPLLARS-VTP--TTIIKQGSSVQTTVT-TTTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxGNxx xxxxx--------------------------------xxxxxxxx---xx xxxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxVT--x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASNGKQSSETTASVKELVK NLLEGKMEPDDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDSEAFV QQSLLP------------QPSTQP-----------AATASAAL------- -----SA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVITLSQ------- -----------TANSKPRx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxxxxxxxx-x-xxxxxx--xx-xxxxxx-AAPSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-VQx---------------------------------------- -------------------------------------------------- -------------------------------------------------F xxxxLI-------------------DAQR--------------------- --------------------------NKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESAR-MATSSELVGI VTRSCKDEAFLSISSLTRIVLQIGKRFGVSELGTDVISYISHATQQRLQN LLEKASQVAQQKNINFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQLELAQMMQREANLTALAAIGPRKKRK-TDSP--------------L SGASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSGPSQPGGSSG-------- -------PGSRQFMRQRITRVNLRDLLLCLENERETSHSQLFYKGLLK-- >ENSACIP00000003932 -------------------------------------------------- ------------------------------------------MAAGSDLL GDVFFNTEVDEKVVTDLVGSLESELKATGxxxxxxxxxxxxxxxxxxxxx ----xxx------------------------------------------- xxxGSKMGLSxxxxxxxxxxxxxx-------------------------- -------------------------------------------------- -------------------GAxxxVxxxx--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xxxx xxxx---------------------------------------------- ------------------------------------------xxxx---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxDKPG- -------------------------------------------------- -------ATGAQTLNGSAxVMNCHxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxx--xxxxxxxVALLKNGPV---------xxxxxxxx xxxx--------------TP-------STIIRAT---------------- ----------------------------------------xxxxxxxIxx -------------xxxxxx------------------------------- ----------------------xx-KTVPTVTLVR-PPMQTPV------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxDCSKTIM-----------------PxxA------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxx--xxxx-------------------------- ----------------------xxxx--xxxxxxSTV----xxx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA IAP--------------------------------------------QV- LAPRLTQPQQNA-P-NI--QNIQLPP---GMVLVRSESGQLLMIHQQALA QM------------------------QAQSQSQ----SAMTPRPPAPTST -PPx--xITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGASLLARP-VTP--TTIIKQCSTVQTTVT-ATTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLA-SGKQSSETTANVKELVK NLLEAKIEPEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLL----------------xxx-----------xxAVSTxx------- -----xx-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVIxxxx------- -----------xxHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------AAQK--------------------- --------------------------NKLKEAGGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGM VTRSCKDETFLSTSSLTRIVLEIGKKFSVSELGTDVINYISHATQQRLQD LLGKVSQVAQQKNMTFK-EDEHYEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRR-MDSP--------------V RGAIAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------RSGSCPSQTGGSSG-------- -------TGSRQFMRQRITRVNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSONIP00000021592 -------------------------------------------------- ------------------------------------------MAAGSDLL GDVFLSTEVDEKVVSDLVGSLESELTETRCDNTTARAPSAENHGGNSAVG ----SSL------------------------------------------- NVQGSKMGLSQQELAKAxxxxxxxxx------------------------ ------------------------x-----------xxxG---------- ------------------TGAQGGVSNST--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xGSS MDGA---------------------------------------------- ------------------------------------------AGIT---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxGKPG- -------------------------------------------------- -------GTGAQTLNGSAVVMNCQxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxx--xxxxxxAVTLLNNGPV---------xVxxxxxx xLPG--------------TP-------STIIRAT---------------- ----------------------------------------xNAQNVVTSS -------------VISSQP------------------------------- ----------------------Sx-xxVPTVTLVR-PPMQTSM------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxDCPKAIM-----------------PTGA------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxVVAxGTxAxxRSPx-------------------------- ----------------------xxxx--LRTSVPSTV----Axx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRT IVP--------------------------------------------QV- LAPRLAQPQQNA-P-NI--QNIQLPPx-TGMVLVRSESGQLLMIPQQALA QM------------------------QAQSQSx----SAMTPRPPAPTST -PPV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGAPLLARP-VTP--TTIIKQCSTVQTTVT-ATTALQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxGVxx xxxxx--------------------------------xxxxxxxxxxxxx xxxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxVT--x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTANVKELVK NLLEAKIEPEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QLSPQP-----------TAAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------TPHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx----------------------- ------------------xxx------------------------xxx-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QTHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-IQV---------------------------------------- -------------------------------------------------- -------------------------------------------------F SQPSFG-------------------TAQK--------------------- --------------------------NKLKE--xxxF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGM VTRSCKDETFLSTSLLTRIVLEIGKKFSVSELGTDVINYISHATQQRLQD VLEKVSQVAQQKNLTFK-EDERYEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------G RGANAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSCPSQTGGSGG-------- -------TGSRQFMRQRITRVNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSPNYP00000028810 -------------------------------------------------- ------------------------------------------MAAGSDLL GDVFLSTEVDEKVVSDLDGSLESELTETRRDNTTARAPSAENHGGNSALG ----SSL------------------------------------------- NVQG---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------x----------------------------- ---------xx-----------xxx------------------------- ----------------xx-----xxx--xxxxxxxxxxxxxxxxxGRPG- -------------------------------------------------- -------ATDAQTLNGGAVVMNCQxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxx--xxxxxxAVTLLNNGPV---------xVxxxxxx xLPG--------------TP-------STIIR------------------ -------------------------------------------------- ------------------x------------------------------- ----------------------xx-xxVPTITLVR-PPMQTSM------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxDCPKVIL-----------------PTGA------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxVVAxGTxAxxRSPx-------------------------- ----------------------xxxx--LRTSVPSTV----Axx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRT IVP--------------------------------------------QV- LAPRLAQPQQNA-P-NI--QNIQLPP---GMVLVRSESGQLLMIPQQALA QM------------------------QAQSQSx----SAMTPRPPAPTST -PPV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGAPLLARP-VTP--TTIIKQCSTVQTTVT-ATTALQRPPVxxxx xxxx-------------------x-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTANVKELVK NLLEAKIEPEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QLSPQP-----------AAAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------TPHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -xx-Gxxxx-x-xxxxxx--xx-xxxxxx-QTHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------x------------ -------------------------------------------------- -------------------------------------------------- ----------xxxxxx---------------------------------- ----------------------------------xRD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGM VTRSCKDETFLSTSLLTRIVLDIGKKFSVSELGTDVINYISHATQQRLQD ILEKVSHVAQQKNLTFK-EDEQYEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------G RGANAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSCPSQTGGSGG-------- -------TGSRQFMRQRITRVNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSNBRP00000029402 -------------------------------------------------- ------------------------------------------MAAGSDLL GDVFLSTEVDEKVVSDLVGSLESELTEARRDNTTARAPSAENHGGNSAVG ----SSL------------------------------------------- NVQG---------------------------------------------- -------------------------------------------------- ------------------xGAQGGVNNST--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xGSS MDGA---------------------------------------------- ------------------------------------------AGIT---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxGRPG- -------------------------------------------------- -------ATDAQTLNGNAVVMNCQxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxx--xxxxxxAVTLLNNGPV---------xVxxxxxx xLPG--------------AP-------STIIRAT---------------- ----------------------------------------xNAQNVVTSS -------------VISSQP------------------------------- ----------------------Sx-xxVPTVTLVR-PPMQTSM------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxDCPKVIL-----------------PTGA------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxVVAxGTxAxxRSPx-------------------------- ----------------------xxxx--LRTSVPSTV----Axx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRT IVP--------------------------------------------QV- LAPRLAQPQQNA-P-NI--QNIQLPP---GMVLVRSESGQLLMIPQQALA QM------------------------QAQSQSx----SAMTPRPPAPTST -PPV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGAPLLARP-VTP--TTIIKQCSTVQTTVT-ATTALQRPPVxxxx xxxx-------------------x-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTANVKELVK NLLEAKIEPEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QLSPQP-----------AAAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------TPHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------xx------------------------------------ ------------------------------------------------xx xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QTHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------x------------ -------------------------------------------------- -------------------------------------------------- ----------xxxxxx---------------------------------- ----------------------------------xRD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGM VTRSCKDETFLSTSLLTRIALDIGKKFSVSELGTDVINYISHATQQRLQD ILEKVSHAAQQKNLTFK-EDEQYEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------G RGANAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSCPSQTGGSGG-------- -------TGSRQFMRQRITRVNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSHBUP00000010741 M------------------------------------------------- --------------------------------RLTNERSWEKMAAGSDLL GDVFLSTEVDEKVVSDLDGSLESELTETRRDNTTARAPSAENHGGNSALG ----SSL------------------------------------------- NVQGSKMGLSQQELAKAx-------------------------------- -------------------------------------------------- ------------------TGAQGGVSNST--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xGSS MDGA---------------------------------------------- ------------------------------------------AGIT---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxGRPG- -------------------------------------------------- -------ATDAQTLNGGAVVMNCQxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxx--xxxxxxAVTLFNNGPV---------xVxxxxxx xLPG--------------TP-------STIIRAT---------------- ----------------------------------------xNAQNVVTSS -------------VISSQP------------------------------- ----------------------Sx-xxVPTITLVR-PPMQTSM------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxDCPKVIL-----------------PTGA------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxVVAxGTxAxxRSPx-------------------------- ----------------------xxxx--LRTSVPSTV----Axx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRT IVP--------------------------------------------QV- LAPRLAQPQQNA-P-NI--QNIQLPP---GMVLVRSESGQLLMIPQQALA QM------------------------QAQSQSx----SAMTPRPPAPTST -PPV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGAPLLARP-VTP--TTIIKQCSTVQTTVT-ATTALQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxGVxx xxxxx--------------------------------xxxxxxxxxxxxx xxxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxVT--x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTANVKELVK NLLEAKIEPEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QLSPQP-----------AAAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------TPHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QAHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-IQA---------------------------------------- -------------------------------------------------- -------------------------------------------------F SQPSFG-------------------AAQK--------------------- --------------------------NKLKE-xxxxF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGM VTRSCKDETFLSTSLLTRIVLDIGKKFSVSELGTDVINYISHATQQRLQD ILEKVSHVAQQKNLTFK-EDEQYEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------G RGANAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSCPSQTGGSGG-------- -------TGSRQFMRQRITRVNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSMZEP00005034783 -------------------------------------------------- ------------------------------------------MAAGSDLL GDVFLSTEVDEKVVSDLDGSLESELTETRRDNTTARAPSAENHGGNSALG ----SSL------------------------------------------- NVQGSKMGLSQQ-------------------------------------- ------------------------xxxxxxxFSCxxxxxG---------- ------------------IGAQGGVSNST--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xGSS MDGA---------------------------------------------- ------------------------------------------AGIT---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxGRPG- -------------------------------------------------- -------ATDAQTLNGGAVVMNCQxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxx--xxxxxxAVTLLNNGP-----------xxxxxxx xLPG--------------TP-------STIIRAT---------------- ----------------------------------------xNAQNVVTSS -------------VISSQP------------------------------- ----------------------Sx-xxVPTITLVR-PPMQTFM------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxDCPKVIL-----------------PTGA------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxVVAxGT--xxRSPx-------------------------- ----------------------xxxx--LRTSVPSTV----Axx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRT IVP--------------------------------------------QV- LAPRLAQPQQNA-P-NI--QNIQLPP---GMVLVRSESGQLLMIPQQALA QM------------------------QAQSQSx----SAMTPRPPAPTST -PPV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGAPLLARP-VTP--TTIIKQCSTVQTTVT-ATTALQRPPVxxxx xxxx-------------------x-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTANVKELVK NLLEAKIEPEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QLSPQP-----------AAAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------TPHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------D------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGM VTRSCKDETFLSTSLLTRIVLDIGKKFSVSELGTDVINYISHATQQRLQD ILEKVSHVAQQKNLTFK-EDEQYEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------G RGANAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSCPSQTGGSGG-------- -------TGSRQFMRQRITRVNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSAPOP00000007877 -------------------------------------------------- ------------------------------------------MAAGSDLL DDVFFNTEVDEKVVSALVGSLECELTAAGQCNTTARVQSAANHVGNSAVG ----SNF------------------------------------------- SVQGNKMGLSQQELAKSx-------------------------------- --------------------------xxxHLFSCxxAxxW---------- ------------------TGVQCGVSNSA--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xGSS MDGA---------------------------------------------- ------------------------------------------AGIT---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxGKPG- -------------------------------------------------- -------VTGVQTLNGSAVVMNCHxx------x----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxx--xxxxx-AVTLVNNGPV---------xVxxxxxx xLSA--------------TP-------STIIRTT---------------- ----------------------------------------xSAQNAVTSS -------------VISSQP------------------------------- ----------------------Sx-xxVPTVTLVR-PPMQSPT------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- -------------------------------------------------- ------------------------x------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxRSPx-------------------------- ----------------------xxxx--LRTSVPSTI----Axx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------AGIRA IAP--------------------------------------------QV- LAPRLTQPQQNA-T-NI--QNIQLPA---GMVLVRSESGQLLMIHQQTLA QM------------------------QAQSQSx----SAMTSRPAAPTST -PPV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGASLLARP-VTP--TTIIKQGSTVQTTVT-ATTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxx-------------------- ---------------------------------xxxxxxxx--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTANVKELVK NLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI KESLLP------------QPSTQP-----------AAAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------TPHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QTHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-VQV---------------------------------------- -------------------------------------------------- -------------------------------------------------L SHASLT-------------------AAQK--------------------- --------------------------NKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGM VTRSCKDEAFLSTSLLTRMALEIGKKFGVSELGTDVINYISHATQQRLQN LLEKVSQVAQQRNVTFK-EDNRSEQVSDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------L RGAS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSGPSQPGGSGG-------- -------TGSRQFMRQRITRVNLRDLLFCLENEKGTSHSHLLYKGFLK-- >ENSAOCP00000003356 -------------------------------------------------- ------------------------------------------MAAGSDLL DDVFFNTEVDEKVVSALVGSLEWELTAAGHCNTTARVHSAANHVGNSAVG ----SNF------------------------------------------- SVQGNKMGLSQQELAK---------------------------------- -------------------------------------------------- ----------------------------xxxx--------------xxx- -------------------------------------------------- --------xxx--------------------------------------- ----------------------------------------------xGSS MDRA---------------------------------------------- ------------------------------------------AGIT---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxGKPG- -------------------------------------------------- -------VTGVQTLNGSAVVMSCHxx------x----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxx--xxxxx-AVTLVNNGPV---------xVxxxxxx xLSA--------------TP-------STIIRTT---------------- ----------------------------------------xSAQNAVTSS -------------VISSQP------------------------------- ----------------------Sx-xxVPTVTLVR-PPMQSPT------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- -------------------------------------------------- ------------------------x------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxRSPx-------------------------- ----------------------xxxx--LRTSVPSTI----Axx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA IAP--------------------------------------------QV- LAPRLTQPQQNA-T-NI--QNIQLPA---GMVLVRSESGQLLMIHQQTLA QM------------------------QAQSQSx----SAMASRPAAPTST -PPV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGASLLARP-VTP--TTIIKQGSTVQTTVT-ATTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxx-------------------- --xxxxx----------xxx------------x-------x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTANVKELVK NLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI KESLLA------------QPSTQP-----------AAAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------TPHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QTHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xxx--------------------xxxxxxxxx xxxxxx-VQV---------------------------------------- -------------------------------------------------- -------------------------------------------------L SQASLT-------------------AAQK--------------------- --------------------------NKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGI VTRSCKDETFLSTSSLTRMALEIGKKFGVSELGTDVINYISHATQQRLQN LLEKVSQVAQQRNVTFK-EDNRSEQVSDVRTQLKFFEELDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------L RGAS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSGPSQPGGSGG-------- -------TGSRQFMRQRITRVNLRDLLFCLENEKGTSHSHLLYKGFLK-- >ENSAPEP00000019291 -------------------------------------------------- ------------------------------------------MAAGSDLL DDVFFNTEVDEKVVSALVGSLEWELTAAGHCNTTARVHSAANHVGNSAVG ----SNF------------------------------------------- SVQGNKMGLSQQELAK---------------------------------- -------------------------------------------------- ----------------------------xxxx--------------xxx- -------------------------------------------------- --------xxx--------------------------------------- ----------------------------------------------xGSS MDGA---------------------------------------------- ------------------------------------------AGIT---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxGKPG- -------------------------------------------------- -------VTGVQTLNGSAVVMSCHxx------x----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxx--xxxxx-AVTLVNNGPV---------xVxxxxxx xLSA--------------TP-------STIIRTT---------------- ----------------------------------------xSAQNAVTSS -------------VISSQP------------------------------- ----------------------Sx-xxVPTVTLVR-PPMQSPT------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- -------------------------------------------------- ------------------------x------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxRSPx-------------------------- ----------------------xxxx--LRTSVPSTI----Axx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA IAP--------------------------------------------QV- LTPRLTQPQQNA-T-NI--QNIQLPA---GMVLVRSESGQLLMIHQQTLA QM------------------------QAQSQSx----SAMASRPAAPTST -PPV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGASLLARP-VTP--TTIIKQGSTVQTTVT-ATTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxx-------------------- --xxxxx----------xxx------------x-------x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTANVKELVK NLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI KESLLA------------QPSTQP-----------AAAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------TPHSKPGxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -----------------------xxx------------------------ ----------------------------------------------x--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxx-VQV---------------------------------------- -------------------------------------------------- -------------------------------------------------L SQASLT-------------------AAQK--------------------- --------------------------NKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGI VTRSCKDETFLSTSSLTRMALEIGKKFGVSELGTDVINYISHATQQRLQN LLEKVSQVAQQRNVTFK-EDNRSEQVSNVRTQLKFFEELDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------L RGAS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSGPSQPGGSGG-------- -------TGSRQFMRQRITRVNLRDLLFCLENEKGTSHSHLLYKGFLK-- >ENSSPAP00000024900 -------------------------------------------------- ------------------------------------------xx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------MVLVRSESGQLLMIHQQTLA QM------------------------QAQSQSx----STMASRPAAPTNT -PPV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGASLLARP-VTP--TTIIKQGSTVQTTVT-ATTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxxx--------------xxxxx xxx-------------------------------------x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTANVKELVK NLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI KDSLLP------------QPSTQP-----------AAAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------TPHSKPGxxxxxxxxxxxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxx-------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxxx xxxxxx-VQV---------------------------------------- -------------------------------------------------- -------------------------------------------------L SQASLT-------------------AAQK--------------------- --------------------------NKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGM VTRSCKDETFLSTSSLTRMALEIGKKFGVSELGTDVINFISHATQQRLQN LLEKVSQVAQQKNITFK-EDDRCEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------L RGASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSGPSQPGGSGG-------- -------TGSRQFMRQRITRVNLRDLLFCLENEKGTSRSHLLYKGFLK-- >ENSLCRP00005003573 -------------------------------------------------- ------------------------------------------MAAGSDLL DDVFFNTELDEKVVSDIVGSLESELSGSDRVNTAAGVQSAGNYAGKSVVG ----SNS------------------------------------------- NVQGSKMGLSQQELAKA--------------------------------- ---------------------------------------G---------- ------------------TGVQGGVINSA--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xGSS MDGA---------------------------------------------- ------------------------------------------AGTTxVVA AAAxxxxxxxxxxxxxxxxxxx---------------------------- ---------xxxxxxxxxxxxxxx-----------------------xxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------GVQTLNGSTVVMNCHxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxx-AVTLVNNGPV---------xVxxxxxx xLSA--------------TP-------STIIRT----------------- -------------------------------------------------- -------------------x------------xxxxx------------- ----------------xxxxxxSx-xxVPTVTLVR-PPMQTPT------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxx-----x----- --xx-----xxxx------------------------------------- ------------------------xxxxxxxxxxx--------------x x----------------------------------xx------------- ---------------------------xxxxxxx---------------- ---xxxxxxxTVA--xxAxxRSPx-------------------------- ----------------------xxxx--LRTSVPSTI----Axx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------AGIRA IAP--------------------------------------------QV- LAPRLTQPQQ-----NI--QNIQLPP---GMVLVRSESGQLLVIHQQTLA QM------------------------QAQSQSx----SAMTPRPAAPTST -PPV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGASLLARP-VTP--TTIIKQGSTVQTTVT-ATTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxGTxx xxxxx--------------------------------xxxxxxxxxxxxx xxxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxIT--x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTANVKELVK NLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI HQSLLP------------QTST-x-x--------xxxASSTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------TPHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QSHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx------------------------xxxxxx xxxxxx-VQV---------------------------------------- -------------------------------------------------- -------------------------------------------------V SQTPLT-------------------AAQK--------------------- --------------------------IKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGA VTRSCKDETFLSTSLLTRRALEIGKKFGVSELGTDVINYVSHATQQRLQN LLEKVSQVALQKNTTFK-EDERFEQADDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------V RGASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSGPSQPGGSSG-------- -------AGSRQFMRQRITRVNLRDLLFCLENERGTSHSQLLYKGFLK-- >ENSLCAP00010041871 M------------------------------------------------- --------------------------------RLTSERSWAKMAAGSDLL DDVFFNTEVDEKVVSDLVGSLESELTGAGHVNATARVQAAANHVGNSAVG ----SNS------------------------------------------- NVQGSKMGLSQQELAKA--------------------------------- ---------------------------------------G---------- ------------------AGVQGGVINSK--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xGSS MDGA---------------------------------------------- ------------------------------------------TGTT---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxGKPG- -------------------------------------------------- -------TTAVQTLNGSTVVMNCHxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxx-AVTLVNNGPV---------xVxxxxxx xLSA--------------AP-------STIIRTTx--------------- ----------------------------------------TSAQNAVTSP -------------VISSQP------------------------------- ----------------------Sx-xxVPTVTLVR-PPMQTPT------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxDSTKTIV-----------------QTGA------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxTVAxGTxAxxRSPx-------------------------- ----------------------xxxx--LRTSVPSTI----Axx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA IAP--------------------------------------------QV- LAPRLTQPQQNA-P-NI--QNIQLPP---GMVLVRSESGQLLMIHQQTLA QM------------------------QAQSQSx----SAMTPRPAAPTST -PPV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----PPGASLLARS-VTP--TTIIKQGSTVQTTVA-ATTKLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxGTxx xxxxx--------------------------------xxxxxxxxxxxxx xxxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxIS--x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTASVKELVK NLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QPSTQP-----------AATASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------TPHSKSGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QPHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-VQV---------------------------------------- -------------------------------------------------- -------------------------------------------------V SQAPLT-------------------AAQK--------------------- --------------------------NKLKEAxGGMF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGT VTRSCKDEAFLSTSSLTRRALEIGKKFGVSELGTDVINYISHATQQRLQN LLEKVTQVAQQKNGTFK-EDERYEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-IYSP--------------V RGASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------SSGSGPSQPGGSSG-------- -------AGSRQFMRQRITRVNLRDLLFCLENEKGNSHSHLLYKGFLK-- >ENSSDUP00000031668 M------------------------------------------------- --------------------------------RLKNERSCAKMAAGSDLL DDVFFNTEVDEKVVSDLVGSLESKLIGASHINTKAKIQSAANHVGNSAVG ----SNS------------------------------------------- NVQGSKMGLSQQELAKA--------------------------------- ---------------------------------------G---------- ------------------TGVQGGIINST--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xGSS MDGA---------------------------------------------- ------------------------------------------AGTT---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxGKAG- -------------------------------------------------- -------KTGVQTLNGSSVVMNCHxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxx-AVTFVNNGPI---------xVxxxxxx xLSA--------------AP-------STIIRTTx--------------- ----------------------------------------ASVHNAVTSP -------------VISSQP------------------------------- ----------------------Sx-xxVPTVTLVR-PPMQTPT------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxDFTKTIM-----------------QTG-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxTVAxGTxAxxRSPx-------------------------- ----------------------xxxx--LRTSVPSTI----Axx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRT IAP--------------------------------------------QV- LAPRLTQPQQNA-P-NI--QNIQLPP---GMVLVRSESGQLLVIHQQTLA QM------------------------QAQSQSx----SAMTPRPAAPTST -PPV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGASLLARS-VTP--TTIIKQGPTVQTTVT-AATKLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxGTxx xxxxx--------------------------------xxxxxxxxxxxxx xxxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxVT--x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTASVKELVK NLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QPSTQPxx--------xxxAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------APHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QPHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx------------------------xxxxxx xxxxxx-VQV---------------------------------------- -------------------------------------------------- -------------------------------------------------V SQAPLT-------------------AAQK--------------------- --------------------------NKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGT MTRSCKDEAFLSTSSLTRRALEIGKKFGVSELGTDVINFISHATQHRLQN LLEKVSQVAQQKNLTFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MYSP--------------V RGDSAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSGPSQPGVSGG-------- -------AGSRQFMRQRITRVNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSSLDP00000014166 M------------------------------------------------- --------------------------------RLTNERSCAKMAAGSDLL DDVFFNTEVDEKVVSDLVGSLESELIGASHVNTEAKIQSAANHVGNSAVG ----SNS------------------------------------------- NVQGSKMGLSQQELAKA--------------------------------- ---------------------------------------G---------- ------------------TGVQGGIINST--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xGSS MDGA---------------------------------------------- ------------------------------------------AGTT---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxGKAG- -------------------------------------------------- -------KTGVQTLNGSSVVMNCHxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxx-AVTFVNNGPI---------xVxxxxxx xLSA--------------AP-------STIIRTTx--------------- ----------------------------------------ASVHNAVTSP -------------VISSQP------------------------------- ----------------------Sx-xxVPTVTLVR-PPMQTPT------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxDFTKTIM-----------------QTG-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxTVAxGTxAxxRSPx-------------------------- ----------------------xxxx--LRTSVPSTI----Axx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRT IAP--------------------------------------------QV- LAPRLTQPQQNA-P-NI--QNIQLPP---GMVLVRSESGQLLVIHQQTLA QM------------------------QAQSQSx----SAMTPRPAAPTST -PPV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGASLLARS-VTP--TTIIKQGSTVQTTVT-AATKLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxGTxx xxxxx--------------------------------xxxxxxxxxxxxx xxxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxVT--x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTASVKELVK NLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QPSTQPxx--------xxxAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------APHSKQGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QPHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-VQV---------------------------------------- -------------------------------------------------- -------------------------------------------------V SQAPLT-------------------AAQK--------------------- --------------------------NKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGT MTRSCKDEAFLSTSSLTRRALEIGKKFGVSELGTDVINFISHATQHRLQN LLEKVSQVAQQKNLTFK-EDERCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MYSP--------------V RGDSAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSGPSQPGVSGG-------- -------AGSRQFMRQRITRVNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSCGOP00000032594 M------------------------------------------------- --------------------------------RLTSERSLGKMAAGSDLL DDVFFNTEVDEKVVSDLVGSLESELTGAGRVNTPTRVQSAANHFGNSAVG ----SNP------------------------------------------- NVQGRNMGLSQQELAKA--------------------------------- ---------------------------------------G---------- ------------------TGVQGGVINST--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xGSS MDGS---------------------------------------------- ------------------------------------------AGTT---- -------------------------------------------------- -------------------------------------------------- --x----------------------------------------------- -------------------------------------------------- ------------------------------------------------xx ----------xxx--------xxxxxxxxxxxx-------------xxxx xxxxxxxTTSVQTLNGSAVMMNCHxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxx-VVTLVNNGPV---------xAxxxxxx xLSA--------------TP-------STIIRTYx--------------- ----------------------------------------TSAPNx---- -------------xxxxxx------------------------------- ----------------------xx-xxVPTVTLVR-PPMQTPT------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxDSTKTIM-----------------QTGA------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxTVx---xPxxRSPx-------------------------- ----------------------xxxx--LRTSLPSTI----Axx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA IAP--------------------------------------------QV- LAPRLTQPQQNA-P-NI--QNIQLPP---GMVLVRSESGQLLVIHQQTLA QM------------------------QAQSQSx----SAMTPRPAAPTST -PPV--QISSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGASLLARP-VTP--TTIIKHGSTGQTTVT-ATTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxGSxx xxxxx--------------------------------xxxxxx------x xxxxxxx------xxxxxxx------------------------------ ----------------------------------xxIT--x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSTETTANVKELVK HLLEAKIEPEGFTSRLYQELSSSPQPYLVPFLKRSLPALRLMTPDADSFI HQSLLP------------LPSPQP-----------AATASTAL------- -----TE-----------------------------------------VM L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------TPHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QSHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx------------------------xxxxxx xxxxxx-VQV---------------------------------------- -------------------------------------------------- -------------------------------------------------V SQAPLT-------------------AAQK--------------------- --------------------------NRLRETxGGAF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGM VTRSCKDEAFLSTSLLTRRALEIGKKFGVGDLGADVINCISHAAQQRLQN LLERVSQVAQQRNTAFK-EDAQCQQVSDVRTQLRFFEQLDQMEKQRKEEL EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------V RAAGAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------CSGSDPSQPGGSSG-------- -------SGSRQFMRQRITRVNLRDLLFCLENEKGTSHSHLLYKGFLK-- >ENSATEP00000022953 M------------------------------------------------- --------------------------------RLTNERSWAKMAAGSDLL DDVFFNTEVDEKVVSDIVGSLESELTGAGHVKAPAGLQSAANHVGNSAVC ----SKS------------------------------------------- NVQGSKMGLSQQELAKA--------------------------------- ---------------------------------------G---------- ------------------TGVKGGVINSL--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xALS MDGE---------------------------------------------- ------------------------------------------SGST---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxGRPG- -------------------------------------------------- -------TTSVQTLNGSTVVVNCHxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxx-AVTLVNNGPV----------------- ----------------------------------xxxxxxxxxxxxxxx- ----------------------xxxxx-----------xxTSAQHTVTSP -------------VISCQP------------------------------- ----------------------Sx-xxVPTVTLAR-PPMQTPT------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxx--------------- -------------------------------------------------- -----------xxx------------------------------xxxxx- ----xxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxVLAxGTxAxxRSPx-------------------------- ----------------------xxxx--VRTSVPSTL----Axx--xS-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA IAP--------------------------------------------QV- LAPRVTQPQQSA-P-NI--QNIQLPP---GMVLVRSESGQLLMIHQQTLA QM------------------------QAQSQSx----SAMTPRPAVPTST -PSV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGTSILARP-VTP--TTIIKQGSTVQTSVT-PTTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx xxxxx--------------------------------xxxxxxxxxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETVENVKKCKNFLSTLIKLASSGKQSSETTANVKELVK NLLEGKIEPEDFTSSLYRELNSSPQPYLVPFLNRSLPALRQMTPDSEAFI QQSLLP------------QPSTQP-----------AVAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------TPHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QPHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-VQV---------------------------------------- -------------------------------------------------- -------------------------------------------------V SQASLT-------------------AAQK--------------------- --------------------------NKMKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATSSELVGT VTRSCKDETFLSTSLLTRRALEIGKKFGVRELGIDVINYLSHATQQRLQN LLEKASQVAQQKNTTFK-EDERYEQVNDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANQTALAAIGPRKKRR-MDSP--------------V RGASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSGPSHPGGSAG-------- -------AGSRQFMRQRITRVNLRDLLSCLENERGTSHSYLLYKGFLK-- >ENSMALP00000032303 -------------------------------------------------- ------------------------------------------MAAGSDLL DDVFFSTEVDEKVVSDLVGSLESELTAAGHVNTTIGIQSAANHVGNLAAR ----SNS------------------------------------------- NVQSRKMGLSQQDLAKA--------------------------------- ---------------------------------------G---------- ------------------TGVQGGVINST--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xNSS MDEA---------------------------------------------- ------------------------------------------AGTP---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xx--------xxxxxxGTPG- -------------------------------------------------- -------TTGVQTLNGSAVVMNCHxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxx-AVTLINNGPV---------xVxxxxxx xLST--------------TS-------STIIRTSx--------------- ----------------------------------------TNAQNTVTST -------------VISCQP------------------------------- ----------------------Sx-xxVPTVTLVR-PPMQTPV------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxDSTKTTV-----------------QSGA------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxTASxGTxAxxRSPx-------------------------- ----------------------xxxx--SRTSVPA-x----Axx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRP IAQ--------------------------------------------QV- LAPRPTQSQPNA-P-NI--QNIQLPA---GMVLVRSETGQLLMIHQQTLA QI------------------------QAQSQSx----SAMTPRPAAPTST -PPV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----TPGASLLARP-VTP--TTIIKQGSTVQSTVT-ATTVLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxGTxx xxxxx--------------------------------xxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxx------------------------------ ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTARVKELVK SLLEAKIEPEDFTSRLYQELNSSPQPCLVPFLKRSLPVLREMTPDSEAFI QQ------------------xxxx-----------xAAPSKAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVINLTQ------- -----------TPHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QPHNxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-IQI---------------------------------------- -------------------------------------------------- -------------------------------------------------I SQAPLI-------------------AAQK--------------------- --------------------------NKLKETxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARIMATNSEIVGM VTHSCKDETFLSTTSLTQRVLEIGKKFGVSELGTEVISYISHAAQQRLQN LLEKMSHVAQQKNLTFK-EDELYEQASDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------V RGANAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSASGPSQAGGS---------- -------SGSRPFMRQRITRVNLRDLLFCLENERGTSHSHLLYKGFLK-- >ENSMAMP00000035928 M------------------------------------------------- --------------------------------RLTRERSWAKMAAGSDLL DDVFFNTEVDEKVVSALVGSLESELTGTGHVNTTSGNQSAANHVGSSVVC ----SNS------------------------------------------- SVQGGKMGLSQQELAKA--------------------------------- ---------------------------------------G---------- ------------------TGVQGGVIGST--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xGSS MDGA---------------------------------------------- ------------------------------------------AGTT---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxGKPG- -------------------------------------------------- -------TTAVQTLNGSSVVINCHxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxx-AVTPVNNGPV---------xAxxxxxx xxxxx------------xxA-------STVIQTSx--------------- ----------------------------------------xSAQNTVTSP -------------VISSQP------------------------------- ----------------------Sx-xxVPTVTLVR-PPMQTPI------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------x--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxx--x---------------------- -----xxxxxTAAxGTxVxxRSPx-------------------------- ----------------------xxxx--LRTSAPSAV----Axx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA IAP--------------------------------------------QV- LAPRLTQPQQNT-P-NI--QNIQLPP---GMVLVRSESGQLLMIHQQTLA QM------------------------QAQSQSx----SAMTPRPAVPTST -PPV--QITSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGTSLLARP-VTP--TTIIKQGSTVPATVT-ATTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxGTxx xxxxx--------------------------------xxxxxxxxxxxxx xxxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxIT--x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTANVKELVK NLLEAKIEPEDFTSRLYRELSSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QTSTQP-----------AAAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLTQ------- -----------TPHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-xLHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-IQV---------------------------------------- -------------------------------------------------- -------------------------------------------------V SQAALT-------------------xxx---------------------- --------------------------NKLKDAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLLEESARILATSS-LVGT VTRSCKDETFLSTSSLTQRALEIGKKFGVSELGTDVISYISYATQQRLQN LLEKVSQVAQQKNITFK-EDQRYEQLSDVRTQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------V RGASAExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxSPPGLRVRP LPAWxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------xxxxxxxxxxxxx -------------------------------------------------- ---------------------------xxx-------------------- -------------------------------------------------- >ENSORLP00000014852 M------------------------------------------------- --------------------------------RFTNERGLAKMAASSDLL GDVFFKTERDEKVKSELIGSLDTESTEESHVNSAGGTQSETNHADSSAIR ----Sxx------------------------------------------- NIQGSKMGLSQQELAKA--------------------------------- ---------------------------------------x---------- ------------------SGVQRGVSSSA--------------------- --------------------xxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- MDGA---------------------------------------------- ------------------------------------------xGVT---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxx---------------------- -----------xxxxxxxxxxxxx-----xxxxxxxxxxxxxxxxEKxx- -------------------------------------------------- ---------GAQSLNGSAAVTNCHx-------xxxxxxx--------xxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxx------------------------------------ ---------------------------------xxxxx------------ -------xxx---------------------------------------- ------------------xP-------STIIRTT---------------- ----------------------------------------xSAQNAPSPG -------------VVPAQPx------------xxx--------------- --------------------------xVPTVTLVK-PLMQTST------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx- ----x--------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxAxxRSPx-------------------------- ----------------------xxxx--PRTAAPSTI----Axx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGVRP PAP--------------------------------------------QV- LAPRLSQPQQNT-T-NI--QNIQLPP---GMVLIRSESGQLLMIHQQTLA QM------------------------QAQSQSx----SAMTPRPAAPTST -PPV--Q-TSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----TPGTPLLTRP-VTS--TTIIKQASPVQTTGI-VTTALQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx --xxx--------------------------------xxxxxxxxxxx-- ----xxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLA-xGKQSPQTSANVKELIK NLLQAKIEPEDFTSRLYKELSSSPQPYLVPFLKRSLPALRQMTPDPDAFI QQSLLP------------LPSTQP-----------VATASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxx--xxxTVISLTQ------- -----------TPQSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------S xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QPHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-VQx---------------------------------------- -------------------------------------------------- -------------------------------------------------L xxxxVA-------------------DAHR--------------------- --------------------------NRLKEAxGGAF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESARILATSSELVGM VTRSCKDEAFLSTPSLTRIALEIGKKFGVSELGTDVISYISHATQQRLQN LLEKVSQVAHHKNVTLK-EDERCEQVSDVRGQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQLELAQIRQREANLAALAAIGPRKKRK-TDSP--------------V KGAGAD-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSSSGPSQPGGSGG-------- -------AGSRQFTRQRITRVNLRDLLFCLENEKETSHSQLLYKGFLK-- >ENSORLP00020032548 M------------------------------------------------- --------------------------------RFTNERGLAKMAASSDLL GDVFFKTERDEKVKSELIGSLDTESTEESHVNSAGGTQSETNHADSSAIR ----Sxx------------------------------------------- NIQGSKMGLSQQELAKA--------------------------------- ---------------------------------------x---------- ------------------SGVQRGVSSSA--------------------- --------------------xxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- MDGA---------------------------------------------- ------------------------------------------xGVT---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxx---------------------- -----------xxxxxxxxxxxxx-----xxxxxxxxxxxxxxxxEKxx- -------------------------------------------------- ---------GAQSLNGSAAVTNCHx-------xxxxxxx--------xxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxx------------------------------------ ---------------------------------xxxxx------------ -------xxx---------------------------------------- ------------------xP-------STIIRTT---------------- ----------------------------------------xSAQNAPSPG -------------VVPAQPx------------xxx--------------- --------------------------xVPTVTLVK-PLMQTST------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx- ----x--------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxAxxRSPx-------------------------- ----------------------xxxx--PRTAAPSTI----Axx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGVRP PAP--------------------------------------------QV- LAPRLSQPQQNT-T-NI--QNIQLPP---GMVLIRSESGQLLMIHQQTLA QM------------------------QAQSQSx----SAMTPRPAASTST -PPV--Q-TSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----TPGTPLLTRP-VTS--TTIIKQASPVQTTGI-VTTALQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx --xxx--------------------------------xxxxxxxxxxx-- ----xxxxxxx-----xxxx------------------------------ ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLA-xGKQSPQTSANVKELIK NLLQAKIEPEDFTSRLYKELSSSPQPYLVPFLKRSLPALRQMTPDPDAFI QQSLLP------------LPSTQP-----------AATASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxx--xxxTVISLTQ------- -----------TPQSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------S xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QPHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-VQx---------------------------------------- -------------------------------------------------- -------------------------------------------------L xxxxVA-------------------DAHR--------------------- --------------------------NRLKEAxGGAF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESARILATSSELVGM VTRSCKDEAFLSTPSLTRIALEIGKKFGVSELGTDVISYISHATQQRLQN LLEKVSQVAHHKNVTLK-EDERCEQVSDVRGQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQLELAQIRQREANLAALAAIGPRKKRK-TDSP--------------V KGAGAD-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSSSGPSQPGGSGG-------- -------AGSRQFTRQRITRVNLRDLLFCLENEKETSHSQLLYKGFLK-- >ENSLBEP00000010312 -------------------------------------------------- ------------------------------------------MAADSDLL GDVLLDAAADEKV------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx NVQRSKMGLSQQEVAK---------------------------------- -------------------------------------------------- ------------------xxxHGGVISST--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xDSN RDGA---------------------------------------------- ------------------------------------------AGTT---- -------------------------------------------------- -------------------------------------------------- --xxxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxx----------------- -------------------------------xxxxxxxxxxxxxxxx--- -----------QTLNGSAVVTSCHxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxx-----------------xxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxx-xxEPTVTLAR-PPMQTPTx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxDTSKT------------------------------------ -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx -------------------------------------------------- -------------------------------------------------- ------------------xxRSSx-------------------------- ----------------------xxxx--LRTSVPSTIxxxxxxx--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------AGIRA IAP--------------------------------------------QV- LAPRLTQTQQNA-P-NI--QNIQLPP---GMVLVRSESGQLLMIHQQTLA QM------------------------QAQSQSx----SAMTPRPAAPTST -PPF--QINSLK-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGTSLLPRP-VTP--MTIIKQASPVQTSVT-ATTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxGSxx xxxxx--------------------------------xxxxxxxxxxxxx xxxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxVT--x--------- -------------------------------------------------- ------------ETLENVKKCRNFLSTLIKLASSGKQSSETTANVKELVK NLLEAKLEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSEAFI QQSLPP------------QPSSQP-----------TTAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVINLTQ------- -----------TTHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QPHNxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx------------------------xxxxxx xxxxxxxVQI---------------------------------------- -------------------------------------------------- -------------------------------------------------V SQSALA-------------------VAQN--------------------- --------------------------HKQKETxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGA VTRSCKDESFLSTSLLTQRALGIGKKFGVSELGSDVINYISYATQQRLQN LLEKVSQVAQQKNMTFK-EDERYKQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------V RGASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSGPSQPGASSR-------- -------SGSRQFTRQRITRVNLKDLLFCMENERETSHSHLLYKCFLK-- >ENSBSLP00000036051 -------------------------------------------------- ------------------------------------------MAAGTDLL DDVFLNTEVDEKVVSDVVGSLESELTETGCVNTSTRVQPAANHTGNS--- -------------------------------------------------- -------------------------xxxxxxxxxxxxx------------ -------------xxxxxxxxxxxx------------------------- ----------------------GGVLNST--------------------- -------------------------------------------------- ---------xx--------------------------------------- ----------------------------------------------xDSS MDGA---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxxxxxxxxx--------------------------- -----------------------------------------------xxx xxxxxxxxxxxx-------------------------------------- -------AAAAQTLNGSAAVMSCHxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxx-AVTLVNNGPV---------xExxxx-- ------------------xxx-----xSTIVRTSx--------------- --------------------------xxxxxxxxxxxxx----------- -----------------QP------------------------------- ----------------------Sx-xxVPTVTLVR-PPMQT--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxx-------------------- -------------------------------------------------- -------------xxxxxxxxxxxxxxxx--------------------- -------xxxxxxxxxxxxxKSPx-------------------------- ----------------------xxxx--LRTSVPSTL----Axx--xA-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------AGIRA AAP--------------------------------------------PA- LAPRITQPQQ-----xx--QNIQLPP---GMVLIRSESGQLLMIHQQTLA QM------------------------QAQSQSx----SAVTPRPAAPTST -PAV--QLTSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----ASGTSILTRS-VTP--TTIIKQGSTVQTTVT-PTTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETLENVKKCKNFLSTLIKLASSGKQSSETTANVKKLVK NLLEGKIEPEDFTSSLYRELSSSPQPYLVPFLNRSLPALRQMTPDAEAFI QQSLGP------------QASSQP-----------AAAASTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxxx--------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxxTVISLPQ------- -----------TSQTKPGxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------I xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-xPHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xxxx-------------------xxxxxxxxx xxxxxx-LQV---------------------------------------- -------------------------------------------------- -------------------------------------------------I SHIx-x-------------------AAQK--------------------- --------------------------NTLNEAxGGSY------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLCEENARILATSSEFVGR VTRSCKDETFLSTSLLTRRALEIGKKFGVSEMGTDVINYISHAAQQRLQT LLEKTSQVAQQKNRTFK-EDERHVQVSDVRTQLKFFEQLDQVEKQRKEEQ EREVLLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRHREANQTALAAIGPRKKRR-MDSP--------------V RGSGAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSGSSHPGGP-x-------- -------xGSRHFMRQRITRVNLRDLLFCLENEKGASHSHLLYKGFLK-- >ENSTNIP00000000446 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxx-xxxxxx--------------------- ------------------xxxxxxxxxTSIIRSxx--------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxx-xxVPTVTLVR-PPGSTPxxx----- ----------------------------------xx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxx-----------------xxxxxx xxxxxxxxxDGPKPII-----------------QTxx------------- -------------------------------------------------- --------------xx---------------------------------- -------------------------------------------------- -----------------xxxxxxx-------------------------- -------------------------------------------------- ---------------------------------xxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------IST---GMVLVRSESGQLLMFQQQNLA QM------------------------KAQSQSx----SAITPRLTVPAST -PPV--QVTSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APAASLLTRA-VTP--TTIIKQVSTVHTTGT-TTATLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxGTxx xxxxx--------------------------------xxxxxxxxxxxx- -------------xxxxxxx------------------------------ ----------------------------------xxxx--A--xxxx--- -----xxx------xx---------------------x------------ -----------xETLENVKKCRNFLSTLIKLTSNGKQSSETTANVKELIK KLLEAKIEPEDFTSRLYQELSSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QIST-x-----------xxxASTAL------- -----AA-----------------------------------------VV L------------------------------------------------- ---xxxxxxxx--------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLPQ------- -----------TPHSKPTx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxxxxLDVLxxVxxxxxxxx-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-xTHSxxxxxxxxxx------ ---------------------xxxxxxxxxxxxxxxxxxxx-xx------ -------------------------------------------------- -------------------------------------------xxxxxxx xxxxxx-VQV---------------------------------------- -------------------------------------------------- -------------------------------------------------V TQSLLH-------------------AAQKx-------------------- -----------------------------xxxxxxxxxLVT--------- -------------------------------------------------- ------------------------NLTSLxFFPDIMIINGRRICWLANGP RDSSREDLLQSCI------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLTEESANILATNSELVGT VTRSCKDEMFLSPSLLSRRALEIGKKFGVSELGADVISYISHATQNRLLN LLEKVSHVAQLKNHNLK-EDGRHEQVCDVRAQLRFFEQLDR--------- -----xxxxxx--------xxxxxxxxxxxxxSRSRQEDPEQLRLKQKAK EMQQQELAQIRHREANLTALAAIGPRKKRK---------------xxxxV RGAGAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------SGGSSG-------- -------PGSRQFMRQRITRVNLRDLLFCLENERGTNRSQLLYKGFLK-- >ENSTRUP00000003317 -------------------------------------------------- ------------------------------------------xx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------MVLVRSESGQLLMFHQQTLA QM------------------------KAQSQSx----SAITPRLSAPAST -PPV--QVASLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APAASLLNRA-VAP--ATIIKQVSTVYTTVA-GTTTLQRPPV---- ---L-------------------Q-------------------------- -------x------------------------------------------ -------------------------------------------------- ---------------------------------------xxxxxxxGTxx xxxxx--------------------------------xxxxxxxxxxxx- --xxxxx------xxxxxxx------------------------------ ----------------------------------xxxx------------ -------------------------------------------------- ------------ETLENVKKCRSFLSTLIKLTSNGKQSSETTANVKELIK KLLEAKIEAEDFTSRLYRELSSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------QTNT-x-----------xxxASTAL------- -----AA-----------------------------------------VV L------------------------------------------------- ---xxxxxxxxx-------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xx-Gxxxx-x-xxxxxx--xx-xxxxxx-PTHSxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLTEESANILATNSELVGT VTRSCKDETFLSPSLLGHRALEIGKKFGVGELGADVVRYISHAAQQRLQD LLEKVSHVAQLRSHILK-EDGRHEQVSDVRAQLKFFEQLDQLERQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRHREANLTALAAIGPRKKRK-TDAPxxxxxxxxxx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------GGSSG-------- -------SGSRQFMRQRITRVNVRDLLFCLENERGTNRSQLLYKGFLK-- >ENSKMAP00000017183 -------------------------------------------------- ------------------------------------------MAAGSDLL GDVFFNRKVDKKVVSELLRFPDSELTGASDSYLTPGVYSAANHV------ -------------------------------------------------- ----xKMGLSQQELPKT--------------------------------- ---------------------------------------x---------- ------------------Vxxxxxxxxxx--------------------- -------------------xx----------------------------- -------------------------------------------------- -----------------------------------------------GSS MDGT---------------------------------------------- ------------------------------------------xGLT---- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxx---------------- ----xxxxxxxx-------------------------------------- -------PAGAETLNGSTAVMNCHxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxx--xxxxx-xxxxxx-GPA---------xAxx---- -------------------------------------xx----------- ---------------xxxxxxxxx----------------xGAQNAVTxP -------------VTSAQP------------------------------- ----------------------Sx-xxVPTVTLVR-PPTQTST------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxx------- -------------------------------------------------- ---xxxxxxxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxxx-----xxxxxRSPx-------------------------- ----------------------xxxx--LKTLAPSTI----AxxxxxP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRT IAP--------------------------------------------QV- LGAQLSQPQRNAxT-SV--QNVQISP---GMVLVRSDSGHYLMIHQQTLA QM------------------------QAQAQSx----SAMTPRPAATTST -PPV--QVTSLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----TAGTPLLGRS-VTPx-TTIIKQGSSAQTTVT-ATTTLQRPPV---- ---L-------------------Q-------------------------- -------x------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxx-------------------------------xxVS------------ -------------------------------------------------- -----------xETLEIVKKCRNFLSTLIKLASSGKQTSETSANVKELVK SLLESKIEPEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSEAFI QQSLLP------------LPSTQP-----------AATAASAL------- -----SA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ------------------------xxxxxxxxxxxxTVISLSQ------- -----------TPNSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-xAPNxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------x------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxx-----------------------xxxxxRD------------- ------------------DDDINDVASMAGVNLSEENARILATGSHLVGM VTRSCTDETFLSVSSLTRITLEIGKKFGVNELGAHVISYISHATQQRLRI LLEKASHVAQQKNTSFK-EDERYEQVSNVRAQLKFFEQLDQLEKQRKDEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAK EMEQLKEAQIRQREANLTALAAIGPRKKRT-ADSP--------------V R------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------xSGPSQPGGSx--------- ---------SRQFMRQRITRVNLRDLLFCLENERETSRSQLLYKGFLK-- >ENSGACP00000019908 -------------------------------------------------- ------------------------------------------xx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxx-------------------------- ----------------------xxxx--xxxxx----------x--xP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGTRA IAP--------------------------------------------QV- LAPRLTQPQQAT-P-NI--QNIQLPP---GMVLVRSESGQLLVIHQQTLA QM------------------------QAQSQSx----SAMTPRAAAPTST -PPV--QIASLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGASPLARP-VAP--TAIIKQGSAVQATVT-PTTTLQRPPI---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxx------ --------xxxxxxxxxx----------------xxxxxxxxxxxxxxxx ---xxxx------xxxxxxx------------------------------ ----------------------------------xxxx--A--------- ------xxxxxxxxxx---------------------x------------ -----------xETLENVKKCRNFLSTLIKLASSGKQSSETIANVKELVK NLLEAKIEPEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSESFI QQSLLP----------------xx-----------xxxTSTAL------- -----TA-----------------------------------------VV L------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxTVISLTQ------- -----------TPPSKPAx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- --------xxxxxxxxxxxxxx---------------------------A xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QPHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx-LQV---------------------------------------- -------------------------------------------------- -------------------------------------------------V SQASLI-------------------AAQR--------------------- --------------------------NKLKEAxGGTFxxxTRSEKLHSAV LNVMQGYKSPWS----------------------------LCIxxxxxxx xVIKQRVLPAAGLLNLNxxHxxxxxx------------------------ -----------xxxV----------------------------------- ---------------------------------LSRD------------- ------------------DDDINDVASMAGVNLSEESDRILATNSELVGA VTRSCKDEAFLSTALLARRALEIGRKFGVSELGPDAANFIAHATQQRLRH LLERVSLVAQHRNGTFK-EDERCEQASDVRTQLRFFEQLD---------- ------xxxxxxxxxxxxxxxx-------xxxSRSRQEDPEQLRLKQKAK EMQQQELAQIRQREANLTALAAIGPRKKRK-MDSP--------------V RGASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------PGGSGG-------- -------SGSRQFTRQRITRVNLRDLLFCLENERGTSRSHLLYRGFLK-- >ENSDCDP00000037608 -------------------------------------------------- ------------------------------------------MAAGSDLL DDVFFNTEVDEKVVSDIVGSLESELTGASPGDTAVRARGLGNHVSGAAGS ----Axx------------------------------------------- NVQDNKVGLA-xxxVxx--------------------------------- ---------------------------------------xx--------- ---xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--- -------------------xx----------------xxxxxx------- ---------xx--------------------------------------- ----------------------------------------------xxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------x---------------------------------- -------------------------------------------------- ------------TLNGGSVVMNSH-------------------------- xxxxxxxxxxxx---------------------------------xxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x--------------------------------------- -------------------------------------------------- -----------------------AVPPVNNGPG---------xVxxxxxx xxxx--------------SS-------xTVIQTSx--------------- ----------------------------------------LST----xxx -------------xxx-xx------------------------------- ----------------------xx--xGPAVTLVR-PPMQAAGxxxxxxx xxxxxxxxxxxxxxxxx-----xxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxESPK------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxxxxx-xxxxxxxxxxTRASVPPNI----Axx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------ATIRA IAP--------------------------------------------QV- LAPRLPNAQPGT-P-NI--QNIQLPP---GMVLVRSESGQLLMIHQQTLA QM------------------------xx--xx------AMAPRPATPTST -PPV--QIASVQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGTPIITRQ-ITP--TTIIKQTQPAQPTVQxATTSLQRPPV---- ---Lxxxxxxxxxxxxxxxxxxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETLENVKKCKNFLSTLIKLASSGKQSSETAANVKELVK DLLEGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSASFI QQSQLQ------------QPSTxx--------------TSTAL------- -----TA-----------------------------------------VV Lxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-xP------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------x------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxRD------------- ------------------DDDINDVASMAGVNLSEESARILATNSDLVGA VMRSCKDEAFLYTSSLNRRMLEIGRKYGVNELGPEVINFVSHATQQRLKN LLEKVSEIAQQKNLSYK-EDERYDQASDVRTQLKFFEQLDQAEKQRKEEQ EREMLMKAAK----------------------SRSRQEDPEQARLKQKAK EMQQQELAQMRQRDANLTALAAIGPRKKRK-LDLQ--------------T GGAVTE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSTSGSAASGASGS-------- -------GVSRQFTRQRITRVNLRDLLFCLENERETSHSHLLYKAFLK-- >ENSCHAP00000050116 -------------------------------------------------- ------------------------------------------MAAGSDLL DDVFFNTEVDEKVVSDIVGSLESELTGSGHGNSAVRVQGVGNHISNSSGS ----Axx------------------------------------------- SVQDNKMGLA-xxxVxx--------------------------------- ---------------------------------------x---------- ------------------xGVPGGVINNTxxx------------------ -------------------------------------------------- -------------------------------------------------- -----------------------------------------------GST MDAA---------------------------------------------- ------------------------------------------xGTT---- -------------------------------------------------- -------------------------------------------------- ---xxxxx-xx-------------------xxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxx-------------------------------------- -------------xxx---------------------------------- -------------------------------------------------- ------------TLNGSNVVINSH-------------------------- xxxxxxxxxxxx---------------------------------xxxxx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xx--------------------------------------- -------------------------------------------------- -----------------------AVTVVNNGPG---------xVxxxxxx xxxx--------------SA-------xTVIHTSx--------------- ----------------------------------------MNTQNVVTxT -------------VIANQT------------------------------- ----------------------xxxxxGPTVTLVR-PPMQTPGxxxxxxx xxxxxxxxxxxxxxxxx-----xxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxESPKTII-----------------QTTTxx-----x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxx xx--------------x-xxxxxxxx-xTRTSVPSTI----Sxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA IAP--------------------------------------------QV- LAPRLPNAQQNQ-P-NI--QNIQLPP---GMVLVRSESGQLLMIHQHTLA QM------------------------xx--xxx----GAMATRPATPTSS -PPV--QITSVQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGTPIIARQ-VTP--TTIIKQGSPAQTTVQ-ATTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xx------------------------------------------------ ---------------xxxxxx--------xxxxxxxxxxxxxxxxx---- ----------------------------------xxxx-xx--------- -------------------------------------------------- ------------ETLENVKKCKNFLSTLIKLASSGKQSSETAANVKELVK SLLEGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSGAFI QQSQLQxxxxxxxxxxxxxxxxxx--------------TSTAL------- -----TA-----------------------------------------VV Lxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------------- --xxx--------------------------------------------- -------------------------------------------------- -------------------------------------VISLTQxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-xPH----------------- -------------------------------------------------- ---------------------xxxxxxxxxxxxxxxxxxxx--------- -------------------------------------------------x xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxx---------xxxxxxAAQK--------------------- --------------------------NKLKEAxGGSF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGA VTRSCKDEAFLFTDSLRRKMLEIGRKYGITELGPDVINFVSHATQQRLQN LLEKVSEVSQQKNIYYK-EDERYDQVSDVRTQLKFFEQLDQMEKQRKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQHELNQMRQRDANLTALAAIGPRKKRK-VESP--------------S SGAGAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSGSAASGASGA-------- -------GGSRQFTRQRIIRVNLRDLLFCLENERETSHSHLLYKAFLK-- >ENSHHUP00000085528 MIKNGNIIDVWCGSFPFGNASRTTTQCNPVCTVVPIFRRAISSGCDSLNA NCNNSSQTVNLVITNQSTLESDVSDGVSNRFxRLTSECSRVKMAAGSDLL DDVFFNTEVDEEVVSDLVGSLESELTGSGRGNSSVRVQAAANNIDNSVVG ----RNS------------------------------------------- NVQDSEMGLS-xxxxxx--------------------------------- ---------------------------------------x---------- ------------------xGVPGAVINSRxxx------------------ -------------------------------------------------- -------------------------------------------------- -----------------------------------------------GST MYAA---------------------------------------------- ------------------------------------------VGTT---- -------------------------------------------------- -------------------------------------------------- ---xxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxRKTG- -------------------------------------------------- -------AAVVQTLNGRSVVINSH-------------------------- xxxxx----------------------------------------xxxxx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xx--------------------------------------- -------------------------------------------------- -----------------------AVAVVNNGPS---------xVxxxx-x xxxx--------------xx-------STVIQTPx--------------- ----------------------------------------M--xxxVTST -------------VISSQL------------------------------- ----------------------SxxxxVPTVTLVR-PPMQTPGxxxxxxx xxxxxxxxxxxxxx-------------xxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxESPKTTI-----------------QTTSxx-----x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxx------------------------- ----------------x-xxxxxxxx--VRTSIPSTI----Axx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------SGIKA IAP--------------------------------------------QV- FSPRLPQPQQNA-S-NI--QNFQLPP---GMVLVRSESGQLLMIHQQTLA QM------------------------xx--xxx----SAMTPRAATPTSS -PPV--QITSAQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGTPMMSRQ-VTPx-TTITKQGSLALTTVQ-ATTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxxxxx xxxxxx-------------------------------------xxx-xxx -xxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxxx-xx--------- -------------------------------------------------- ------------EILENVKKCKNFLSTLIKLASSGKQSSETTANVKELVK SLLEGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSAAFI QQSQLP------------HAGAQP------------xxSSKAL------- -----TA-----------------------------------------VV Lxxxxx-------------------------xxxxxxxx---xxxxxxxx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------VISLAQ------- -----------TPHSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-xPHSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxx---------xxxxxxVVLK--------------------- --------------------------NRQKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESARILATNSEVVGM VTRSCKDEAFLHTSSLTQRVHEIGRRLGVTDLGPEVINYVSHATQHRLQN LLEKVTVVAQQKNITFK-EDDKCEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELNQIRQKEANMTALAAIGPRKKRK-MNSP--------------V SGTGAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------DLYSGPSPSGGYSS-------- -------GGSRP-QRQRITRVNLRDLLFCLENESETSRSHLLYKGFLK-- >ENSHHUP00000045140 -------------------------------------------------- ------------------------------------------MAAGSGSL EDVFYDTEVDDKVVSDLVGSLESELTGSGRGNSAARVQAAGNHIGKSSVG ----GHS------------------------------------------- NVQDSKMGLS-xxxxxx--------------------------------- ---------------------------------------x---------- ------------------xxxxxxxxxxxx-------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx MGTA---------------------------------------------- ------------------------------------------AGTT---- -------------------------------------------------- -------------------------------------------------- ---xxxxx-xxxxxxxxxxx------------------------------ -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxGKTG- -------------------------------------------------- -------SAGVQTLNGSSVVMNSH-------------------------- ----------------------------------------------xxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------VTVVNNGPG---------xVxxxx-x xxxx--------------xx-------SAVIQTSx--------------- ----------------------------------------M--xxxxxxx -------------xx----------------------------------- -------------------------xxVPTVTLVR-PPMQTPGxxxxxxx x-xxxxxxxxxxxx-------------xxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxESPKTTI-----------------QKTAxx-----xxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------x----------------------------- ---------------------------------xxxI----xxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA IAP--------------------------------------------QV- LAPRLPQPQQNA-P-NI--QNIQLPP---GMVLVRSESGQLLMIHQQTLA QM------------------------xx--xxx----SPMTPRPATPTST -PPV--QITSVQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGMPLMARQ-VTP--TTIIKQGSPAQTTx------LQRPPV---- ---L-------------------Q----------xxxxxxxxxxxxxxxx xxxxxxxx------------------------------------------ -------------------------------------------------- ---------------------------------------xxx-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------LENVKKCKNFLSTLIKLASSGKQSSETTASVKDLVK SLLEGKIEAEEFTSRLYRELNSSPQPYLVPFLKRSLPALRQMTPDSTAFI QQSQLP------------QASVQP------------xxSSTAL------- -----TA-----------------------------------------VV Lxxxxx-------------------------xxxxxxxxxxxxxxxxxxx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------VISLAQ------- -----------TPHSKPCx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------P xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-QSHSxxxxxxxx-------- ----------------------------------------x-xxxxxxxx x-------------------xx-----------------xxx-------- -xxxxxx----------xxx----------------------xxxxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxx---------xxxxxxVAQK--------------------- --------------------------NKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESAHILATNSELVGA VTRSCKDEAFLYTTSLTRRVQEIGRRFGVTDLGPEVINYVSHATQQRLQN LLEEVTEVAQQKNITFK-EDDKYEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELNQIRQKEANMTALAAIGPRKKRK-MESP--------------x xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------SGPSSSGGASS-------- -------GGSRP-QRQRITRVNLRDLLFCLENERETSSSHLLYKGFLK-- >ENSELUP00000016499 -------------------------------------------------- ------------------------------------------MAAGSNLL DDVFFNAEVDEKVVSDLVGSLESELTGSGRGNSAVRVQAAANHIDNTAVG ----GNS------------------------------------------- NVQDNKIGLS-xxxxxx--------------------------------- ---------------------------------------x---------- ------------------xxxxxxxx-xxxxx------------------ -------------------------------------------------- -------------------------------------------------- -----------------------------------------------GST MDAA---------------------------------------------- ------------------------------------------TGTT---- -------------------------------------------------- -------------------------------------------------- ---xxxxx-xxxxxxxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- ---------------xx--------xxxx-----------------KTG- -------------------------------------------------- -------PAGVQTLNGSSVLMNSQ-------------------------- xxxxx----------------------------------------xxxxx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xx--------------------------------------- -------------------------------------------------- -----------------------ALTVVNNGPG---------xVxxxx-x xxxx--------------xx-------STVIQTSx--------------- ----------------------------------------M--xNAVTxT -------------VISSLP------------------------------- ----------------------SxxxxVPTVTLVR-PPMQTPGxxxxxxx xxxxxxxxxxxxxx-------------xxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxDSSKTII-----------------QTTSxx-----x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxx------------------------- ----------------xxxxxxxxxx--VRTTIASSI----Axx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------CGIRA IAP--------------------------------------------QV- LAPRHPLPQQNA-P-NI--HNIQLPP---GMVLVRHENGQLLMIHQQTLA QM------------------------QAQSQSx----SAMTPRPATTNST -PPA--QISSxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxxxxx-------------------------------------xxxxxxx -xxxxxxxxxxx-xxxxxxx------------------------------ ----------------------------------xxxx-xx--------- -------------------------------------------------- ------------ETLDNVKKCKNFLSTLIKLASSGKQSAETTANVKQLVK SLLEGHIEVEDFTSRLYQELNSSPQPYLVPFLKRSLPALRQMTPDSAAFI QQSQLP------------QASVKP------------xxxx-AL------- -----TA-----------------------------------------VV Lxxxxx-------------------------xxxxxxxxxxxxxxxxxxx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------GISLAQ------- -----------TPQSKPGx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------S xxx-Gxxxx-x-xxxxxx--xx-xxxxxx-xHNSxxxxxxxx-------- ----------------------------------------x-xxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxx---------xxxxxxVAQK--------------------- --------------------------NKLKEAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGS VTRSCKDEAFLYTSSLTRRVQEIGRRFGVTDLGPEVINYVSHATQQRLQD LLEKASEVAQQRNITFK-EEDKHDQTSDVRAQLKFFEQLDQMERQRKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELNQIRQREANMTALAAIGPRKKRK-MDSP--------------L SGATAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GTGSGPSPSAGANS-------- -------GGSRP-QRQRITRVNLRDLLFCLENERESSRSHLLYRGFLK-- >ENSSFOP00015007079 -------------------------------------------------- ------------------------------------------MAAGSDLL DEVFFNTEVDEKVVSDLVGSL----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxAGIRP IAP--------------------------------------------QV- LAPRLPQATQNP-P-NI--QNIQLPP---GMVLVRSDSGQLLMIHQQTLA QM------------------------QAQSxSx----SAMTPRPATPTST -PQV--QIAPVQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----GPGTSILTRQ-MTP--TTIIKQTSPGQASVP-ATTTLQRPPV---- ---L-------------------Q-------------------------- -------xxxxxxx------------------------------------ ----------------xxxxxxxxxxxxxxxxxxx--------------- --------------------------------------xxxx-------- -------------------------------------------------- ---------------xxxxx------------------------------ ----------------------------------xxTT--x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASSGKQSSETAANVKDLVK SLLEGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRAMTPDSAAFI -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxxxxxxxx-------- -------------------------------------------------- ---------------------xx--------------xxSLPQ------- -----------TGHAKPG---------------------------xxxxx -------------------------------------------------- -------------------------------------------------- ------xx------------------------------------------ -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Gxxxx-xxxxxxxx--xx-xxxxx--xPHSxxxxxxxx-------- ----------------------------------------xQxxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxxxAAQK--------------------- --------------------------NKPKDAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGA VTRSCKDEAFLYTATLHRRLLEIGKKYGIVELGPEVVNLVSHATQQRLQD LLEKVSQVAQQKNISFK-DDSRHEQISDVRAQLKFFEQLDHMEKQKKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQMRQRDANLTALAAIGPRKKRK-LDWP--------------G GGAGAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSSPSLSGGSGA-------- -------AASRQFTRQRITRVNLRDLLFCLENEKGTSHSHLLYRAFLK-- >ENSPKIP00000017193 -------------------------------------------------- ------------------------------------------MAAGSDLL DEVFFHTEVDEKVVSDLVGSLESELAGSGHANSQAKGQALANHV----xx xxxxGxx------------------------------------------- NVQESKVGLA-xxxAxx--------------------------------- ---------------------------------------x---------- ------------------xGVQGGVINNTxxx------------------ -------------------------------------------------- -------------------------------------------------- -----------------------------------------------GSA MDAA---------------------------------------------- ---------------------------------------------x---- -------------------------------------------------- ---------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxx ------------------------------------------------xx xxxxxx-------------------------------------------- ---------------------------------------------GKSG- -------------------------------------------------- -------TSAVQTLNGSS-VINSH-------------------------- xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxx-------------------xxxxxxx-------- -------------------------------------------------- -----------------------AVTVVNNGPG---------xxxxxx-x xxPP--------------------x-xxTVIQTSx--------------- ----------------------------------------MNTQxxxxxx -------------xxxxxx------------------------------x ----------------------xx-xxAPGVALVR-PPMQAAGxxxxxxx x-xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------Px-------------xxx---------- ---------------------------xTRAPTPSSx----xxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------AGIRA IAP--------------------------------------------PV- LAPRLSQAAPSQ-P-NI--QNIQLPP---GMVLVRSDSGQLLMIHQQTLA QM------------------------QAQSQSx----SAMAPRPATPTST -PPV--HITSVQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----GPGTPILARQ-VTP--TTIIKQASGVQASVQ-TTTTLQRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxx- -xxxx--------------------------------xxxxxxxxxx--- --xxxxx-----xxxxxxxx------------------------------ ----------------------------------xxAT--x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASSGKQSSETAANVKDLVK NLLEGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRAMTTDSAAFI QQSQLQ------------QP---------------xxxxTTSL------- -----TT-----------------------------------------VV M---------------------------xxxxx----------------- ---xx------xxxxxxxxxxxx---------------xxxx-------- -------------------------------------------------- ---------------------xx--------------VISLAQ------- -----------AGHSKPGx--------------xxxxxxxxxxxxxx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxx-xxxxxxxx--xx-xxxxx--xPHSxxxxxxxx-------- ----------------------------------------xQxxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxxxATQK--------------------- --------------------------NKLKDAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEENARILATNSELVGA VTRSCKDEAFLYTATLHRRVLNIGKKYGIAELGPEVVNFVSHATQQRLQD LLEKVSQIAQQKNFSFK-DDSRYEQISDVRSQLKFFEQLDQMEKQRKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRK-LDWP--------------G TGAGAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGVSPSLSGATGT-------- -------GSSRQFTRQRITRVNLRDLLFCLETERESSHSNLLYRAFLK-- >ENSELUP00000004592 -------------------------------------------------- ------------------------------------------MAEGSDLL DEVFFNTEVDEEVVSNLVGSLESELSGWVHGNPWVRCQTVVKH--xxxxx ----xxx------------------------------------------- xxxxxxxxxx-xxxxxx--------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxxxxxxxxxx-xxxxxxxxx----------------------- ------------------------------xxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xx---------------------------xxxxxxxx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EAPKTII-----------------QTAx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xxxx--------------------------- ---------------------xPx-------------xxx---------- ---------------------------xxxxxxPVTV----xxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GAIRA IAP--------------------------------------------QM- LAPRLPQTSPNQ-P-NV--QNIQLPP---GMVLVRSESGQLLMIHQQTLA QM------------------------QAQSHSx----GAMAPRPDTPTST -AQV--QITSVQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGTPILSRQ-LAPxSTTIIKQGMSVPTCAP-ITTTLQRPP----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxx--xxxx xxxxxxxx------xxxxxxxxxxxxxxxxxxxxxxxx------------ -----------xETMENVKKCKNFLSTLIKLASSGKQSEETVTNVKDLVK DLLEGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRKLTPDSARFI EQSGLQ------------Q------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxxxxx--------xxxxxx------------------------------ --------------xxxxxxxxx--------------xxx---------- ---------------KQG---------------------------xPASx -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Gxxxx-xxxx------xx-xxxxxxxxxHSxxxxxxxx-------- ----------------------------------------x--xxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxx---------xAVQQ--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGA VTRSCKDEAFLHASALTRRILEMGKKFGVSDLGPEVVSYVSHATQTRLTN LLEKVSEVAQQRNINLK-EDSRYEQTSDVRAQLKFFEQLDQMEKQRREEQ QREILMKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELFQLRQKEANLTALAAIGPRKKRR-TEA---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSSPSASGSGSS-------- -------GASRQFVRQRITRVNLRDLLFCLENERDTSHSHLLYRGFLK-- >ENSHHUP00000074005 -------------------------------------------------- ------------------------------------------MAAGSDLL DEVFFNAEVDEKVVRDLVGSLESELSG--xxxxxxRSQTVAKHMASxxxx ----xNA------------------------------------------- NVQQNERGLA-xxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxASxxxxxxxxxxxxx-xxxxxxxxx----------------------- ------------------------------xxxxxxxxxxxxxxxx---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------QTLNGGS-LMNCH-------------------------- xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x----------------------------xxxxx------ -------------------------xxxxxx-xx---------------- -----------------------AVTVVNNGPGx-xxx--xxx------x xxxx--------------------xxxTTIIQTSx--------------- ----------------------------------------VNSQxxxxxx xxxxxxxxxxxxxx------------------------------------ ---------------------------------VR-PSMQTAGxxxxxxx x-xx---------------------------------------------- ------------------xxxxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EAPKTII-----------------QTG-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xxx--------------------------- ---------------------xxx-------------xxx---------- ---------------------------xxxxxxPVTV----xxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGSRS IAQ--------------------------------------------QV- LAPRHPQTSPNQ-P-NV--QNIQLPP---GMVLVRSESGQLLMIHQQTLA QM------------------------QSQSQSx----GVMAPRPATPTST -PPF--QITSVQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGTPILTRQ-VTP--TTIIKQGSPVPTSAP-VTTTLQKPP----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxx- -xxxx--------------------------------xx---xxxxx--- --xxxxx-----xxxxxxxx------------------------------ ----------------------------------xxLA--x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASSGNQSSETAANVKDLVK DLLEGKIEVEDFTNRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QHSGLQ------------Q------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxxxxx--------xxxxxx------------------------------ --------------xxxxxxxxx--------------xxx---------- ---------------KPG---------------------------xTTPx -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Gxxxx-xxxx------xx-xxxxxxxxxHSxxxxxxxx-------- ----------------------------------------xQxxxx---- -------------------------------------------------- ------------------xx----------------------xxxxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxx---------xAVQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGA VTRSCKDEAFLHTSTLTRRILEIGKKFGVSDLGPEVVNYVSHASQTRLQN LLEKVSEVAQQKNINFK-EDSRYEQTSDMRAQIKFFEQLDQMEKQRKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELFQLRQKEANLTALAAIGPRKKRK-MEAA--------------A AAAGAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSSPSASGSGSS-------- -------GASRQFIRQRITRVNLRDLLFCLENERDTSHSHLLYKGFLK-- >ENSFHEP00000005286 -------------------------------------------------- ------------------------------------------xx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVG- -------------------------------------------------- -------TYSAQTFNGSQ-TMNAH-------------------------- xxxxxxxxxxxxxxSVxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxx-xx---------------- -----------------------AAAALGTGTAx-xxxxxx--------x xxxx--------------SS-------xSVIQTPx--------------- ----------------------------------------VNADx----- ------------xxxx----------------xxxx-------------- ---------------------------GPTVTLVR-PPMQTVGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxAANAxxQTGA---------------------------GTQNxPVx xxx-xxxxxx-----xxxxxxxxxx------------------------- ---------EPPAAII-----------------PPAPxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxx----------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------PGAPG MAP--------------------------------------------QM- LAPRLPQTSPGQ-P-SV--HNIQLPP---GMVLVRSESGQLLMIPQQALA QM----------------------xxxxxxx------GGMAPRTAMPASV -SA-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGTTIVSRQ-VSQ--STIIRPGCPAPASLA-ATTALHRPSI---- ---L-------------------P-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxx---xxxxxxxxxxx--------------- -------------AGxxxxx------------------------------ ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASSGKQSTETAATVSNLVK ELLEGTLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASVA-----------VSSASATS------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------VTQ-G---------------------------xTTSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xxxxxxxxx-xTPGxxxxxxxx-------- ---------------------------------------------x---- --------------------------------------xxx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------x-----------xxxxxxxxxxxV SAVALT-------------------QAQK--------------------- --------------------------NKLREA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDEAFLSCAALQRRALEIGARHGVTELGAEVVNYISHATQQRLLN LLEKVSLVAQQKNVNFKxEDDGYEQSSDVRAQLRFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRKxLDSP--------------S SSASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGSSLPGAAGS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSHSHFLYKGFLK-- >ENSGAFP00000030159 -------------------------------------------------- ------------------------------------------xx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVV- -------------------------------------------------- -------SYSVQTFNGSQ-TMNSH-------------------------- xxxxxxxxxxxxxxSGxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxx-xx---------------- -----------------------SAAAASTGAVx-xxxxxx--------x xxxx--------------SS-------xSVIQTPx--------------- ----------------------------------------INSDx----- ---------------x----------------xxxx-------------- ---------------------------GPTVTLVR-PPMQTAGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxAANAxxQTGI---------------------------GMQNxPVx xx------xx-----xxxxxxxxxx------------------------- ---------EPPTTII-----------------QSAPxx----------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxx---------------------xxxx----------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------------xAGAPG ITT--------------------------------------------QM- LAPRLPQASPAQ-P-SV--HNIQIPP---GMVLVRSESGQLLVIPQQALA QMx--------------------xxxxxxxx------GGMAPRTATPTNV -SA-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGTTIINRQ-VSP--GAIIRPGCPPPVSLT-ATTALHRAPI---- ---L-------------------S-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxx---xxxxxxxxxxx--------------- -------------PGxxxxx------------------------------ ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASSGKQSTETAATVRELVK DLLEDKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASVA-----------VSSTSATS------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------VSQ-G---------------------------xTTSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xTPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxx-----------xxxxxxxxxxxV SAVALT-------------------QAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGFVGA VTHSCKDEAFLSFALLQRRMLQIGMKYGVTEFSTEVVNYVSHATQHRLLN LLEKVSHVAQQKNINFK-EDDSYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKKKxLDSP--------------S SSASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGSSLTGTAGS-------- -------SGSRL-TRQRITRVNLRDLLFCLENERFTSHSHFLYKGFLK-- >ENSPFOP00000005672 -------------------------------------------------- ------------------------------------------xx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVA- -------------------------------------------------- -------SYSVQTFNGSQ-TMNSH-------------------------- xxxxxxxxxxxxxxSGxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxx-xx---------------- -----------------------xxxxxxxxxxx-xxxxxx--------x xxxx--------------SS-------xSVIQTPx--------------- ----------------------------------------MNSDx----- ------------xxxx----------------xxxx-------------- ---------------------------GPTVTLVR-PPMQTAGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxAANAxxQTGI---------------------------GTQNxPVx xx------xx-----xxxxxxxxxx------------------------- ---------EPPTTII-----------------QSAPxxxx--------- -------------------------------------------------- -------------------------------------------------- ---xxxxx---xxx---------------------xxxx----------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------------xAGAPG ITT--------------------------------------------QM- LAPRLPQTSPGQ-P-SV--HNIQIPP---GMVLVRSESGQLLVIPQQTLA QM------------------------xxxxx------GGMVPRTATPTNV -SA-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGATIISRQ-VSP--GTIIRPGCPPPVSLA-ATTALHRAPI---- ---L-------------------P-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxx---xxxxxxxxxxx--------------- -------------PGxxxxx------------------------------ ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASSGKQSTETAATVRELVK DLLEDKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASVA-----------VSSTSATC------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------VSQ-G---------------------------xTTSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xTPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxx-----------xxxxxxxxxxxV SAVALT-------------------QAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDEAFLSYALLQRRMLEIGMKYGVTELGTEVVNYVSHATQQRLLN LLEKVSQVAQQKNINFKxEDDSYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKKKxLDSP--------------S SSASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGLSLTGAAGS-------- -------SGSRL-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSPREP00000024331 -------------------------------------------------- ------------------------------------------xx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVS- -------------------------------------------------- -------SYPVQTFNGSQ-TMNFH-------------------------- xxxxxxxxxxxxxxSGxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxx-xx---------------- -----------------------SAAAVSTGAVx-xxxxxx--------x xxxx--------------SS-------xSVIQTPx--------------- ----------------------------------------MNSDx----- ------------xxxx----------------xxxx-------------- ---------------------------GPTVTLVR-PPMQTAGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxAANAxxQTGI---------------------------GTQNxPVx xx------xx-----xxxxxxxxxx------------------------- ---------EPPTTII-----------------QSAPxxxx--------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxx---------------------xxxx----------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------------xxGAPG ITT--------------------------------------------QM- LAPRLPQTSPGQ-P-SV--HNIQIPP---GMVLVRSESGQLLVIPQQTLA QM------------------------xxxxx------GGMVPRTTTPTNV -SV-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGTTIISRQ-VSP--GTIIRPGCPPPVSLA-ATTALHRAPI---- ---L-------------------S-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxx---xxxxxxxxxxx--------------- -------------PGxxxxx------------------------------ ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASSGKQSTETAATVRELVK DLLEDKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASVA-----------VSSPSATC------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------VSQ-G---------------------------xATSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xTPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxx-----------xxxxxxxxxxxV SAVALT-------------------QAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDEAFLSYALLQRRMLEIGMKYGVTELGTEVVNYVSHATQHRLLN LLEKVSQVAQQKNINFKxEDDSYEQSSDVRAQLKYFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKKKxLDSP--------------S SSASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGSSLTGAAGS-------- -------SGSRL-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSPMEP00000032733 -------------------------------------------------- ------------------------------------------xx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVA- -------------------------------------------------- -------SYSVQTFNGSQ-TMNSH-------------------------- xxxxxxxxxxxxxxSGxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxx-xx---------------- -----------------------SAAAGSTGAVx-xxxxxx--------x xxxx--------------SS-------xSVIQTPx--------------- ----------------------------------------MNSDx----- ------------xxxx----------------xxxx-------------- ---------------------------GPTVTLVR-PPMQTAGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxAANAxxQTGI---------------------------GTQNxPxx xx------xx-----xxxxxxxxxx------------------------- ---------EPPTTII-----------------QSAPxxx---------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxx---------------------xxxx----------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------------xAGAPG ITT--------------------------------------------QM- LAPRLPQTSPGQ-P-SV--HNIQIPP---GMVLVRSESGQLLVIPQQTLA QM------------------------xxxxx------GGMVPRTATPTNV -SA-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGATIISRQ-VSP--GTIIRPGCPPPVSLA-ATTALHRAPI---- ---L-------------------P-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxx---xxxxxxxxxxx--------------- -------------PGxxxxx------------------------------ ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASSGKQSTETAATVRELVK DLLEDKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASVA-----------VSSTSATC------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------VSQ-G---------------------------xTTSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xTPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxx-----------xxxxxxxxxxxV SAVALT-------------------QAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xRD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDEAFLSYALLQRRMLEIGMKYGVTELGTEVVNYVSHATQQRLLN LLEKVSQVAQQKNINFKxEDDSYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKKKxLDSP--------------S SSASAEx------------------------------------------- ----------------xxxxxxxxxxxxxxxxxxxxx---------xxxx -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx xxxxxxxxxxxxxxxxxx-------------------------------- -------------------------------------------------- >ENSXCOP00000023265 -------------------------------------------------- ------------------------------------------xx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------S---GMVLVRSESGQLLVIPQQTLA QM------------------------xxxxx------GGMAPRTATPTNV -S------------------------------------------------ -------------------------------------------------- -------------------------------------------------- ----APGTTIISRQ-VSP--GAIIRPGCPPPVSLA-ATTALHRAPI---- ---L-------------------P-------------------------- -------x------------------------------------------ ---------------xxx-------------------------------- -------------------------------------xx----------- --------------------x---xxxxxxxxxxx--------------- -------------PGxxxxx------------------------------ ----------------------------------VTxx--xx-------- ----------------------------------------x--------- -----------xETMENVKKCKNFLSTLIKLASSGKQSTETAATVRELVK DLLEDKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLT------------QPASVA-----------VSSTSAMS------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---x-x--------xxxxxx------------------------------ ------------xxxxxxxxxxx---------------------x----- -------------VSQ-G---------------------------xTTSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-QTPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xxxx-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------x------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDEAFLSYALLQRRMLQIGMKYGVTELGTEVVNYISHATQQRLLN LLEKVSHVAQQKNINFK-EDDSYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKKKxLDSP--------------S SSAS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGSSLPGTVGS-------- -------SGSRL-TRQRITRVNLRDLLFCLENERFTSHSHFLYKGFLK-- >ENSXMAP00000010027 -------------------------------------------------- ------------------------------------------MAVGPSLL DELFSQTGENKAVVCHPPRSVESQLSL----------------------- -------------------------------------------------- -------------------------------------xxxxxx------- --xxxxxxxxxxxx-------------------------x---------- -------------------------------------------------- -------------------xx----------------------------- ---------xxx-------------xxxxxxxx----------------- -------------------------xxxxxxxxxxxxxxxxxxxxxxGSA MDASxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVA- -------------------------------------------------- -------SYSVQTFNGSQ-TMNSH-------------------------- xxxxxxxxxxxxxxSGxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxx-xx---------------- -----------------------SAAAVSTGAVx-xxxxxx--------x xxxx--------------SS-------xSVIQTPx--------------- ----------------------------------------MNSDx----- ------------xxxx----------------xxxx-------------- ---------------------------GPTVTLVR-PPMQTAGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxAANAxxQTGT---------------------------GTQNxPVx xx------xx-----xxxxxxxxxx------------------------- ---------EPPTMII-----------------QSAPxx----------- -------------------------------------------------- -------------------------------------------------- ------xxxxxxxx---------------------xxxx----------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------------xAGAPG ITT--------------------------------------------QM- LAPRLPQASPGQ-P-SV--HNIQIPP---GMVLVRSESGQLLVIPQQTLA QM------------------------xxxxx------GGMASRTATPTNV -S------------------------------------------------ -------------------------------------------------- -------------------------------------------------- ----APGTTIISRQ-VSP--GAIIRPGCPPPVSLA-ATTALHRAPI---- ---L-------------------P-------------------------- -------x------------------------------------------ ---------------xxx-------------------------------- -------------------------------------xxxxxx------- -----------------xxxx---xxxxxxxxxxx--------------- -------------xxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASSGKQSTETAATVRELVK DLLEDKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLT------------QPASVA-----------VSSTSAMS------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ ------------xxxxxxxxxxx---------------------x----- -------------VSQ-G---------------------------xTTSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xTPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xxxx-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------x---------------xxxxxxxxxV SAVALT-------------------QAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xRD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDEAFLSYALLQRRMLQIGMKYGVTELGTEVVNYVSHATQQRLLN LLEKVSHVAQQKNINFK-EDDSYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKKKxLDSP--------------S S--x---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGSSLPGTAGS-------- -------SGSRL-TRQRITRVNLRDLLFCLENERFTSHSHFLYKGFLK-- >ENSSDUP00000029075 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------RKVG- -------------------------------------------------- -------SYSVQTFNGSQ-TMNSH-------------------------- xxxxxxxxxxxxxxSGxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxx-xx---------------- -----------------------SVAAVNSGPVx-xxxxxx--------x xxxx--------------SS-------xSVIQTHx--------------- ----------------------------------------MNSQx----- ------------xxxxxQxx------------xxxx-------------- ---------------------------GHTVTLVR-PPMQTAGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxVANTxxQSGI---------------------------SIQTxLVx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPPTTII-----------------QSASxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xAxV----xxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA LTP--------------------------------------------QM- LAPRVPQTSPGQ-P-SI--HNIQLPP---GMVLVRSESGQLLMIPQQTLA QM------------------------xxxxx------GGMTPRTATPTNV -PP-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGN-IISRQ-VAP--SNIIRQGCPTPTSLA-ATTTLHRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxx---xxxxxxxxxxx--------------- -------------AGxxxxx------------------------------ ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASTGKQSTETAASVRELVK DLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASSP-----------VASTSPxxx------ ----xTT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------VNKPG---------------------------xIPPL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxxxxxxxI SAAALT-------------------PAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDETFLSCTMLQRRMLEIGRRHGVTDLGAEVVNFVSHATQQRLQN LLEKVSQVAQQKNVNLK-EDGNHEQSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRRxLDSP--------------S SSAVAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGSSLSGGAGS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSSLDP00000014585 -------------------------------------------------- ------------------------------------------MAVRPGPL DELFLHTEVNKAVVCxxxxxxxxxxx------------------------ -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxxxxxxx-------------------------x---------- -------------------------------------------------- -------------------xx----------------------------- ---------x---------------------------------------- --------------------------------------------xxxxxx xxASxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------RKVG- -------------------------------------------------- -------SYSVQTFNRSQ-TMNSH-------------------------- xxxxxxxxxxxxxxSGxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxx-xx---------------- -----------------------SVAAVNSGPVx-xxxxxx--------x xxxx--------------SS-------xSVIQTHx--------------- ----------------------------------------MNSQx----- ------------xxxxxQxx------------xxxx-------------- ---------------------------GHTVTLVR-PPMQTAGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxVANTxxQSGI---------------------------SIQTxLVx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPPTTII-----------------QSASxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xAxV----xxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA LTP--------------------------------------------QM- LAPRVPQTSPGQ-P-SI--HNIQLPP---GMVLVRSESGQLLMIPQQTLA QM------------------------xxxxx------GGMTPRTATPTNV -PP-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGN-IISRQ-VTP--SNIIRQGCPTPTSLA-ATTTLHRPPV---- ---L-------------------Q-------------------------- -------xx----------------------------------------- ------------xxxxxx-------------------------------- ----------------------------------xxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASTGKQSTETAASVRELVK DLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASSP-----------VASTSPxxx------ ----xxxxx-----------------------------------xxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xxxxxxxx---- -------------------------------------------------- -------------------------------------------------- -----------xxxxxx--------------------------------- ------------------------------------------xxxxxxxI SAAALT-------------------PAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDETFLSCTMLQRRMLEIGRRHGVTDLGAEVVNFVSHATQQQLQN LLEKVSQVAQQKNVNLK-EDGNHEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKKRxLDSP--------------S SS------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGSSLSGGAGS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSATEP00000023870 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------MNSH-------------------------- xxxxxxxxxxxxxxSGxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxx-xx---------------- -----------------------SVTAVNSGAVx-xxxxxx--------x xxxx--------------SS-------xSVIQTPx--------------- ----------------------------------------MNSQx----- ------------xxxxxPxx------------xxxx-------------- ---------------------------GPTVTLVR-PPMQTPGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxVAxxxxxxGV---------------------------GIQTPHVx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPPTTII-----------------QSAPxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xAxV----xxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRT LAP--------------------------------------------QM- LAPRLPQTSPGQ-P-SV--HNIQLPP---GMVLVRSESGQLLMIPQQALA QMx--------------------xxxxxxxx------GNIAPRSATPSNV -PP-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGNTIISRQ-VTP--S----------------TTTLHRPPI---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxx---xxxxxxxxxxx--------------- -------------AGxxxxx------------------------------ ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETMENVTKCKNFLSTLIKLASTGKQSTETAASVRQLVK DLLEGKLEAEEFTSRLYKELKSSPQPYLVPFLKRSLPTLRQLTPDSAAFI QQSQLP------------QPASGP-----------VSSTSPTP------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------INKPG---------------------------xTPSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxxxxxxxV SAAALT-------------------LAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDETFLSCTILQRRMLEIGRRYGVTDLGAEVVNYVSHATQQRLQN LLEKVSQVAQQKNFSFK-EGDTYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRKxLDSP--------------S SSSAAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGTSLSGGAGS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSACIP00000015771 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------MVLVRSESGQLLMIAQQALA QM------------------------xxxxx------GDMAPRATTPTNV -PP-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxAPGNTVISRQ-VTP--STIIRPGCPAPTPLT-ATTTLHRPPI---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETIENVKKCKNFLSTLIKLASTGKQSTETAASVRELVK DLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLA------------QxxxGS-----------VSSTSPTP------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------INKPG---------------------------xMTSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-x-xxxx-xAPGxxxxxxxx-------- ----------------------------------------xxxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxxxx---- -----------------xDDDINDVASMAGVNLSEESANILATNSITVGA VTHSCKDEAFLSCAILQRRMLEIGRRHGVTELGPEVVNYVSHAAQQRLQN LLEKVSQVAQQKNISFK-EDNNHEQSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRKxLDSP--------------S SSAS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGPSLSGGPAS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSMZEP00005001168 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVG- -------------------------------------------------- -------SYSAQTFNGSQ-TMNSH-------------------------- xxxxxxxxxxxxxxSGxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxx-xx---------------- -----------------------SVTAVNSGPVx-xxxxxx--------x xxxx--------------SS-------xSVIQTPx--------------- ----------------------------------------MNSQx----- ------------xxxxxQxx------------xxxx-------------- ---------------------------GPTVTLVR-TPMQTVGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxAASAxxQTGI---------------------------GMQTPLVx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPPTTIT-----------------ESAPxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xAxA----xxx---T-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA LAP--------------------------------------------QM- LAPRLPQATPGQ-P-SI--HNIQLPP---GMVLVRSDSGQLLMIPQQALA QM------------------------xxxxx------GDLAPRATTPTNV -PP-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----TPGNTVISRQ-VTP--STIIRPGGPAPASLT-ATTTLHRPPI---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxx---xxxxxxxxxxx--------------- -------------AGxxxxx------------------------------ ----------------------------------xxFS--x--------- -------------------------------------------------- ------------ETIENVKKCKNFLSTLIKLASSGKQSTETAATVRELVK DLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLA------------QPASGS-----------VSSTSTTP------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------INKPG---------------------------xMPSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPSxxxxxxxx-------- ----------------------------------------xHxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxxxxxxxV LVAALT-------------------PAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSITVGA VTHSCKDEAFLSCAVLQRKMLEIGRRYGVTELGPEVVNYVSHAAQQHLQN LLEKVSQVAQQKNITFK-EDNNHEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKKRxLESP--------------S SSASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGPSLSGGPAS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSHBUP00000010335 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVG- -------------------------------------------------- -------SYSAQTFNGSQ-TMNSH-------------------------- xxxxxxxxxxxxxxSGxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxx-xx---------------- -----------------------SVTAVNSGPVx-xxxxxx--------x xxxx--------------SS-------xSVIQTPx--------------- ----------------------------------------MNSQx----- ------------xxxxxQxx------------xxxx-------------- ---------------------------GPTVTLVR-TPMQTVGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxAASAxxQTGI---------------------------GMQTPLVx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPPTTIT-----------------ESAPxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xAxA----xxx---T-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA LAP--------------------------------------------QM- LAPRLPQATPGQ-P-SI--HNIQLPP---GMVLVRSESGQLLMIPQQALA QM------------------------xxxxx------GDLAPRATTPTNV -PP-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGNTVISRQ-VTP--STIIRPGGPAPASLT-ATTTLHRPPI---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxx---xxxxxxxxxxx--------------- -------------AGxxxxx------------------------------ ----------------------------------xxFS--x--------- -------------------------------------------------- ------------ETIENVKKCKNFLSTLIKLASSGKQSTETAATVRELVK DLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLA------------QPASGS-----------VSSTSTTP------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------INKPG---------------------------xMPSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPSxxxxxxxx-------- ----------------------------------------xHxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxxxxxxxV LVAALT-------------------PAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSITVGA VTHSCKDEAFLSCAVLQRKMLEIGRRYGVTELGPEVVNYVSHAAQQHLQN LLEKVSQVAQQKNITFK-EDNNHEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKKRxLESP--------------S SSASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGPSLSGGPAS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSPNYP00000025945 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVG- -------------------------------------------------- -------SYSAQTFNGSQ-TMNSH-------------------------- xxxxxxxxxxxxxxSGxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxx-xx---------------- -----------------------SVTAVNSGPVx-xxxxxx--------x xxxx--------------SS-------xSVIQTPx--------------- ----------------------------------------MNSQx----- ------------xxxxxQxx------------xxxx-------------- ---------------------------GPTVTLVR-TPMQTVGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxAASAxxQTGI---------------------------GMQTPLVx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPPTTIT-----------------ESAPxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xSxA----xxx---T-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA LAP--------------------------------------------QM- LAPRLPQATPGQ-P-SI--HNIQLPP---GMVLVRSDSGQLLIIPQQALA QM------------------------xxxxx------GDLAPRATTPTNV -PP-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGNTVISRQ-VTP--STIIRPGGPAPASLT-ATTTLHRPPI---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxx---xxxxxxxxxxx--------------- -------------AGxxxxx------------------------------ ----------------------------------xxFS--x--------- -------------------------------------------------- ------------ETIENVKKCKNFLSTLIKLASSGKQSTETAATVRELVK DLLEGKLEAEEFTSRLYKELNSSPQPHLVPFLKRSLPALRQLTPDSAAFI QQSQLA------------QPASGS-----------VSSTSTTP------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------INKPG---------------------------xMPSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPSxxxxxxxx-------- ----------------------------------------xHxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxxxxxxxV LVAALT-------------------PAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSITVGA VTHSCKDEAFLSCAVLQRKMLEIGRRYGVTELGPEVVNYVSHAAQQHLQN LLEKVSQVAQQKNITFK-EDNNYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKKRxLESP--------------S SSASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGPSLSGGPAS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSACLP00000029056 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------MNSH-------------------------- xxxxxxxxxxxxxxxxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxx-xx---------------- -----------------------SVTAVNSGPVx-xxxxxx--------x xxxx--------------SS-------xSVIQTPx--------------- ----------------------------------------MNSQx----- ------------xxxxxQxx------------xxxx-------------- ---------------------------GPTVTLVR-TPMQTVGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxxxxxx---------------------------xxxxxxxx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPPTTIT-----------------ESAPxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xAAA----xxx---T-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA LAP--------------------------------------------QM- LAPRLPQATPGQ-P-SI--HNIQLPP---GMVLVRSDSGQLLMIPQQALA QM------------------------xxxxx------GDLAPRATTPTNV -PP-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETIENVKKCKNFLSTLIKLASSGKQSTETAATVRELVK DLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSATFI QQSQLA------------QPASGS-----------VSSTSTTP------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------INKPG---------------------------xMxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPSxxxxxxxx-------- ----------------------------------------xHxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------x-----------xxxxxxxxxxxV LVAALT-------------------PAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------D------------- ------------------DDDINDVASMAGVNLSEESANILATNSITVGA VTHSCKDEAFLSCAVLQRKMLEI-RRYGVTELGPEVVNYVSHAAQQHLQN LLEKVSQVAQQKNITFK-EDNNHEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKKRxLES---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------x-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSONIP00000025602 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxxxxxI---------------------------GMQTPLVx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPPTTIT-----------------ESAPxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xAxA----xxx---T-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA LTP--------------------------------------------QM- LAPRLPQATPGQ-P-SI--HNIQLPP---GMVLIRSDSGQLLMIPQQTLA QM------------------------xxxxx------GDLAPRATTPTNV -PP-------xxxxxxxxTCTQLMKT------------------------ ------PVEQNIR------------------LYNLQCMG----------- -------------------------------------------Sxx---- -xxxAPGNTVISRQ-VTP--STIIRPGCPAPASLT-ATTTLHRPPI---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxx---xxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETIENVKKCKNFLSTLIKLASSGKQSTETAATVRELVK DLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLTRSLPALRQLTPDSAAFI QQSQLA------------QPASGS-----------VSSTSTTP------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------INKPG---------------------------xMPSL xxxxxxxxxxxxxxSTDNLIIWHSTYLNGERTSFSCLESLCSPEEKSCLR NKGLLGKSIAKHGEDKxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxx------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPSxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xxxxxxxx---- -------------------------------------------------- -------------------------------------------------- ----------------xxxx---------------------------xxx xxxxxxx---------------xxxxx-----------xxxxxxxxxxxV LVAALT-------------------PAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSITVGA VTHSCKDEAFLSYAILQRKMLEIGRRYGVTELSPEVVNYVSHAAQQRLQN ILEKVSQVAQQKNITFK-EDNNYEQSSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRK--DSP--------------S SSASAEx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxx--------------------- ---------SRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSAPEP00000033340 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- x---------------------xx--xxxx-------------------- --------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVG- -------------------------------------------------- -------SHSAQTFNGNQ-TMNSH-------------------------- xxxxxxxxxxxxxxSSxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxx-xx---------------- -----------------------SVTAVTSGPVx-xxxxxx--------x xxxx--------------SA-------xTVIQTPx--------------- ----------------------------------------MNSQx----- ------------xxxxx----------------xxx-------------- ---------------------------GATVTLAR-PPMQTAGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxAVSxx---xV---------------------------GAQTxLVx xx------xxxxxx---xxxxxxxx------------------------- ---------EPPTTII-----------------QAAPxx----------- -------------------------------------------------- -------------------------------------------------- -------xx--xxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xVxV----xxx---A-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA LTP--------------------------------------------QM- LAPRLPQTSPGQ-P-SV--HNIQLPP---GMVLVRSESGQLLMIPQQALA QM----------------------xxxxxxx------GGMAPRTTTPTNV -PP-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGNTIISRQ-VSS--STIIRQGCPTPASLA-ATTTLHRPPI---- ---L-------------------P-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxx---xxxxxxxxxxx--------------- -------------xGxxxxx------------------------------ ----------------------------------xxxx--x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASSGKQSTETAASVRELVK DLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASGP-----------ASSTSPTP------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------LNKPG---------------------------xTASL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xx-xxx-xVPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxxxxxxxI SAAALT-------------------SAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DEDINDVASMAGVNLSEESANILATNSGLVGV VTHSCKDEAFLSCAMLQRRMLEIGKKYGVTDLGVEVVNYVSHATQQRLQN LLEKVSEVAQQRNITFK-EDDNYEQSSDVRVQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANMTALAAIGPRKKRKxLDSP--------------S SSASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGPSLSGGPGS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTNRSHFLYKGFLK-- >ENSAPOP00000000626 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxxxxxxxxxxxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVG- -------------------------------------------------- -------SYSAQTFNGNQ-TMNSH-------------------------- xxxxxxxxxxxxxxSGxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxx-xx---------------- -----------------------SVTAVTSGPVx-xxxxxx--------x xxxx--------------SA-------xTVIQTPx--------------- ----------------------------------------MNSQx----- ------------xxxxx----------------xxx-------------- ---------------------------GATVPLVR-SPMQTAGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxAVSxx---xV---------------------------GVQTxFVx xx------xxxxxx---xxxxxxxx------------------------- ---------EPPTTII-----------------QAAPxx----------- -------------------------------------------------- -------------------------------------------------- -------xx--xxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xVxV----xxx---A-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA LTP--------------------------------------------QM- LAPRLPQTSPGQ-P-SV--HNIQLPP---GMVLVRSESGQLLMIPQQALA QMx--------------------xxxxxxxx------GGMAPRTTTPTNV -PP-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGNTIISRQ-VSS--GTIIRQGCSTPTSLT-ATTALHRPPI---- ---L-------------------P-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxx---xxxxxxxxxxx--------------- -------------TGxxxxx------------------------------ ----------------------------------xxLS--x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASSGKQSTETAASVRELVK DLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASGP-----------ASSTSPTP------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------VNKPG---------------------------xTASL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xx-xxx-xVPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxxxxxxxI SAVALT-------------------LAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DEDINDVASMAGVNLSEESANILATNSGLVGV VTHSCKDEAFLSCTMLQRRMLDIGRRYGVTDLGVEVVNYVSHATQQRLQN LLEKVSEVAQQKNITFK-EDDNYEQSSDVRVQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANMTALAAIGPRKKRKxLDSP--------------S SSASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGPSLPGGPGS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSLCRP00005039130 -------------------------------------------------- ------------------------------------------MAVGSGPL DEPYLHTEVNKAVVCxxxxxxxxxxx------------------------ -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxxxxxxx-------------------------x---------- -------------------------------------------------- -------------------xx----------------------------- ---------xx--------------------------------------- -------------------------------------------xxxxxxx xxASxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxx-xxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVG- -------------------------------------------------- -------SYSVQTFNGSQ-TMNSH-------------------------- xxxxxxxxxxxxxxSGxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxx---------------- -----------------------AVTAVNSGPVx-xxxxxx--------x xxxx--------------SS-------xSVIQTPx--------------- -------------------------------------------------- --------------xxxQxx------------xxxx-------------- ---------------------------GPTVTLVR-PPMQTAGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxVAxxxxxxGI---------------------------AIQTxLVx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPPTTII-----------------QSAPxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxx------------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xAxV----xxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------SGIRA MTP--------------------------------------------QM- LAPRLPQTSPGQ-P-SI--HNIQLPQ---GMVLVRSESGQLLMIPQQALA QMxx------------------xxxxxxxxx------GGMAPRAATPTSV -PP-------xx---xxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- ------------RQ-VTP--STIIRQGC--xxxxA-ATTTLQRPPI---- ---L-------------------Q-------------------------- -------xxx--xxxxxxxxxxxx----------------xxxxx----- ----------xxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETMDNVKKCKSFLSTLIKLASTGKQSTETAASVRELVK DLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QLASAP-----------VSSTSLTP------- -----ST-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------VSKPG---------------------------xTSSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPGxxxxxxxx-------- ----------------------------------------xHxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxxxxxxxV CAAALT-------------------PAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDEAFLSCAMLQRRMLEIGRRYGVTDLGAEVVNYVSHATQQRLQS LLEKVSQVAQQKNVNFK-EDDNYEQNSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRKxLDSP--------------S x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------SGSGSSLSGGAGS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSLCAP00010045537 -------------------------------------------------- ------------------------------------------MAVRPGPL DKLFLHTEVNKAVVCxxxxxxxxxxx------------------------ -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxxxxxxx-------------------------x---------- -------------------------------------------------- -------------------xx----------------------------- ---------xx--------------------------------------- -------------------------------------------xxxxxxx xxASxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVG- -------------------------------------------------- -------SYSVQTFNGSQ-TMNSH-------------------------- xxxxxxxxxxxxxxSGxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxx-xx---------------- -----------------------SVAAVSSGPVx-xxxxxx--------x xxxx--------------SS-------xSVIQTPx--------------- ----------------------------------------MNSQx----- ------------xxxxxQxx------------xxxx-------------- ---------------------------GPTVTLVR-PPMQTAGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxVANTxxQSGI---------------------------GIQTxLVx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPPTTII-----------------QSTPxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxV----xxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------SGIRA LTP--------------------------------------------QM- LAPRLPQNSPGQ-P-SI--HNIQLPP---GMVLVRSESGQLLMIPQQALA QM------------------------xxxxx------GGVTPRTATPTNV -PP-------xx---xxxx------xxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASTGKQSTETAASVRELVK DLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASSP-----------ISSTSTNP------- -----AT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------ISKPG---------------------------xTPSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPGxxxxxxxx-------- ------------------------------------------xxxx---- --------------------------------------xxxxxxxx---- -------------------------------------------------- -------------------------------------------------- -----------x-----xxx---------------------------xxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxxxxxxxxDDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDEAFLSCTLLQRRMLEIGRRYGVTDLGAEVVNYVSHATQQRLQN LLEKVSQVAQQKNVNLK-EDDNYEQSSDVRAQLKYFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRKxLDSP--------------S SSAT---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGPSLSGGAGS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSPRNP00000004277 -------------------------------------------------- ------------------------------------------MAESSGPL DELFLHTGVNKAVVCxxxxxxxxxxx------------------------ -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxxxxxxx-------------------------x---------- -------------------------------------------------- -------------------xx----------------------------- ---------x---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xx-xxxxxx--------x xxxx--------------TS-------xSVIQTPx--------------- ----------------------------------------MNSQx----- ------------xxxxxHxx------------xxxx-------------- ---------------------------GPTLALVR-PPMQNSGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxTANTxxQTSI---------------------------GIQTxLVx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPPTTII-----------------QSAAxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xGxV----xxx---D-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRT PTP--------------------------------------------QM- LAPRLPQTVAGQ-P-SI--QNIQLPP---GMVLVRSESGQLLMIPQQALA QMx--------------------xxxxxxxx------GGITPRTPAPTNV -PP-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGNPIISTQ-VSP--STIIRPGCPTPTSLS-ATTTLHRPPV---- ---F-------------------Q-------------------------- -------xx----------------------------------------- -----------------xx-------------xxxxxxxxxxxxxxxxxx xxxxx---------------------------xxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETIENVKKCKNFLSTLIKLASSGKQSTETAATVRELVK DLLEAKLEVEEFTSRLYKELNSPPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QPASGP-----------VSSTSTTS------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------VSKPG---------------------------xAPSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------S xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xxxx-------- -------------------------------------------------- -------------------------------------------------- -------------x------------------------------------ ----------------------------------------xxxxxxxxxI SAAGLT-------------------PAQK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSIIVGA VTHSCKDEAFLSFAMLQRRMLEIGKRYGVTDLGAEVVNSVSHATQQRLQN LLEKVSQVAQQKSSNLK-EDDNYRHSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKKKxPDSP--------------S SS------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGPSLHGGPGS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSCSEP00000007330 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVG- -------------------------------------------------- -------SYLVQTFNGSQ-TMNSH-------------------------- xxxxxxxxxxxxxxSGxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxx------------------- -------------------------xxVNSGSVxxxxxxxx--------x xxxx--------------AS-------xSVIQTPx--------------- ----------------------------------------MNSQx----- ------------xxxxxQxx------------xxxx-------------- ---------------------------GPTVTLVR-PPVHT----xxxxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxx--------------xxGTQPxLVx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPPTTLI-----------------QSALxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xAxV----xxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRT LTP--------------------------------------------QM- LAPRLPQTSPGQ-P-SI--HNIQLPP---GMVLVRSESGQLLMIPQQALA QM------------------------xxxxx------GGIAPRTATPSNV -ST-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----ATGN--INRQ-VAP--SAIIRQGCAAPTTLA-ATTTLHRPPI---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxx----xxxxxxxxxxx--------------- -------------AGxxxxx------------------------------ ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETMENVKKCKNFLATLIKLASTGKQSTEAAPIVRELVK DLLEGKLEAEEFTSRLYKELKSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQAP------------QTTASP-----------VSSPSLTPxx----- ----xTT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------ISKPG---------------------------xTPTM -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxxxxxx-xxxxxx-xAPSxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxx---xxV PAAALT-------------------PANK--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGV VTHSCKDEAFLSCALLQRRMLEIGRRHGVTDLGADVVNFVSHAAQQRLQN LLENVSQVAQQKNVSFK-EDHNCEQSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRKxLDSP--------------S SSAVAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGSSSSVGTGS-------- -------SASRP-TRQRITRVNLRDLLFCLENERFTSSSHFLYKGFLK-- >ENSSMAP00000020780 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GRVG- -------------------------------------------------- -------SYSSQTFNGSQ-TMNCH-------------------------- xxxxxxxxxx-xxxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xx---------------- -----------------------SPAAVHGGPVx-xxxxxx--------x xxxx--------------AS-------xSVIQTPx--------------- ----------------------------------------VNSQx----- ------------xxxxxLxxxxxxxAxxxxxxxxxx-------------- ---------------------------GATVTLAR-PPAQAAGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xx---------xxxV---------------------------GAHTxLVx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPPATIS-----------------QSAPxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xAxA----xxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------VGIRA LTP--------------------------------------------QM- LVPWLPPTSARP-P-GI--HNIQLPP---GMVLVRSESGQLLVIPQQALA QM------------------------xxxxx------GGTAPRTATPTNV -PP-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----SPGN--ISRQ-VAP--STIIRQGCPAPTSLA-ATTTLHRPPI---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxx---xxxxxxxxxxx--------------- -------------AGxxxxx------------------------------ ----------------------------------x-----x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASTVSQSTETAATVRELVK ELLEGKVEAEEFTSRLYKELNSQPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------KPGSQR-----------VSSISPTP------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------VSKPG---------------------------xTPSx -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxxxxxxxV SAAALT-------------------PAQR--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEENANILATNSGLVGA VTHSCKDEAFLSCAMLQRRMLEIGRSYGVTDLGAEVVNYVSHATQHRLQN LLEKVSQVAQQKNVNLK-EDDNNEQGSDVRAQLKFFEQLDLLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRKxLDSP--------------S SSAAAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGP-------x-------- -------xGSRP-TRQRITRVNLRDLLFCLEEERFTSRSHFLYKGFLK-- >ENSGACP00000013177 -------------------------------------------------- ------------------------------------------x------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --P--------------------------------------------QM- LAPRLPQTNPGQ-P-SIGxHNIQLPP---GMVLVRSESGQLLMIPQQALA QM------------------------xxxxx------GGLTPRAATPTSA -PP-------xx-------------------------------------- --------------------------------------xx---------- ------------------------------------------xxx----- ----APGN--ISRQ-VAP--GP-IRQSCAAPT-----TTTLHRPPV---- ---L-------------------Q-------------------------- -------xx----------------------------------------- ------------xxx----------------------------------- -------------------------------------xxxxxx------- -----------------xxxx---xxxxxxxxxxx--------------- -------------AGxxxxx------------------------------ ----------------------------------xxMS--x--------- -------------------------------------------------- ------------ETIENVKKCKNFLSTLIKLASTGKQSTETAASVRELVK ELLEGRLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQLP------------QTPSGP-----------VPSTSPVP------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------ISKP--------------------------------- -------------------------------------------------- -------------------------------------------------- -----xx------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------S xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-QAPGxxxxxxxx-------- ----------------------------------------xHxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxxxxxxxV SAASLS-------------------LAQR--------------------- --------------------------NELKQP-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------EDDINDVASMAGVNLSEESANILATNSRLVGV VTHSCKDEAFLSFSVLQKTMQEIGRRHGVTDLGAEVVNFVSHATQHRLMD LLEKVSQVALQKNLNSK-EDGKYEPSSNVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRKxLDSP--------------S SSSAAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------xxxPSLSGGGGP-------- -------SASRP-TRQRITRVNLRDLLFCLENERSTSHSHFLYKGFLKxx >ENSBSLP00000028202 -------------------------------------------------- ------------------------------------------xx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------GMVLVRSESGQLLMIPQQALA QM------------------------xxx-----------VPRSATPTGV -PPIxx---SSQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----SAGNTIITRQ-VAP--x----------------TTTLHRPPI---- ---L-------------------Q-------------------------- -------xx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx xxxxxxxxxxxxETIENVKKCKNFLATLIKLASSGKQSTETAASVKELVK DLLEGKLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPTLRQLTPDSDAFI QQSQTP------------QSASGL-----------ASSTSPSP------- -----AT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------VSKPG---------------------------xTPSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-QAPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xxxxxxxxx--- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------KLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDEAFISCALLQRRMLEIGRRYGVTDLGAEVVNYVSHATQQHLQK LLEKVSQVAQQKNVSFK-GDNNYEQSSDVRVQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRKxLDPS--------------S SSSAAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------SGGAGS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSTNIP00000004874 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------RA LTP--------------------------------------------QV- LAPRLPLTSPGQ-P-SV--HNIQIPP---GMVLIQSESGQLLLIPQQALA QM------------------------xxxxx------GGVAARTATPTNA -SP--xQVSFSQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----ATGNTVVSKP-VAP--STIIHPGCAAPTSLP-VTTTLHRPPV---- ---L-------------------Q-------------------------- --------------------------------------------xxxxxx xxxxxxxxxxx--------------------------------------- ----------------------------------------xxx------- -----------------xxx-----xxxxxxxxxx--------------- -------------AGxxxxx------------------------------ ----------------------------------xxMS--x--------- -------------------------------------------------- ------------ETIENVKKCKNFLSTLMKLASTGKQSPETAALVRELVK DLLDGKLEAEEFTSRLYKELNSSPQPYLVPFLMRSLPALRQLTPDSTAFI QQSQLP------------QPASAP-----------VTSASAIS------- -----ST-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------VTKPG---------------------------xSTSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-PAPSxxxxxxxx-------- ----------------------------------------xQxxxxxxxx xxxxxxx-------------xx------------xxxxxxx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxA SAPALT-------------------PSQR--------------------- --------------------------NQLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSELVGV VTRSCKDEAFLSASLLQRRMLEIGRRFGVTDLGAEVVKYVSHAAQQRLQS LLEKVSLVAQQRHISFK-EDERYEQDGDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQLRQREANLTALAAIGPRKKRKxLDSP--------------S SSS----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxSGSRP-VRQRITRVNLRDLLFCLENERFTSRSHFLYKSFLNxx >ENSTRUP00000029009 -------------------------------------------------- ------------------------------------------x------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxxxxx-xx------------------------------ --------------xx-----------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKIG- -------------------------------------------------- -------SYPVQTFSGSQ-TMNSH-------------------------- xxxxxx----------------xxxx----------xx------------ --------------xxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xx--------------------------------- -----------------------xxx------------------------ -----------------------------------xxxxxx--------x xxxx--------------TS-------xSVIQTPx--------------- ----------------------------------------MTSQx----- ------------xx---Qxx------------xxxx-------------- ---------------------------GPTVTLAR-PPMQSGRxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxx----xxxxxGT---------------------------AVQTxVxx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPP----------------------------xxxxx----- -------------------------------------------------- -------------------------------------------------- xxxx---xxxxx------------------------xxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xGxV----xxx---Q-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGVRA LTP--------------------------------------------QA- LAPRLPHTSPGQ-P-SV--HNIQIPP---GMVLVQSESGQLLMIPQQALA QV------------------------QAxxxxxxxxxGGGAPRTATPTNV -SP-------VQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGGTVISKP-VAP---TIIHQGCPAPTSLP-ATTTLHRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxx-----xxxxxxxxxx--------------- -------------AGxxxxx------------------------------ ----------------------------------xxMS--x--------- -------------------------------------------------- ------------ETIENVKKCKNFLSTLMKLASTGKQSPETAALVRELVK DLLDGKLEAEEFTGRLYKELNSSPQPYLVPFLMRSLPALRQLTPDSTAFI QQSQLP------------QPSSAP-----------VTSASPIS------- -----ST-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------VTKLG---------------------------xTTSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPAxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xxxxxxxxxxxx xxxxx------------------------------xxx------------ -------xxxxxxx--------xxxxxx---------------------- -------------x------------------------------------ ----------------------------------------xxxxxxxxxV SATALT-------------------PAQK--------------------- --------------------------NQLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSELVGV VTHSCKDEAFLSTSLLQRRILEIGRKYGVTDLGAEVVKYVSHATQQRLQN LLEKVSLVAQQRHISFK-EDDNYEQGSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQLRQREANLTALAAIGPRKKRKxLDSP--------------S SSSGAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTCPSLSSGAGT-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKSFLK-- >ENSORLP00020034139 -------------------------------------------------- ------------------------------------------xx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxxxxxxxx--------------------------------- ------------xxx--xx--------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVD- -------------------------------------------------- -------SNSAQTFNGSQ-TMNSH-------------------------- xxxxxx-------------------------------------------- ----------------xxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxx---------------------------------- -------------------------------------------------- ------------------------------xxxx-xxxx----------x xxxx--------------SS-------xGVIQAPx--------------- ----------------------------------------LNSDxx---- -----------xxxxxxQxx------------xxxx-------------- ---------------------------GHTVTLIR-QPMQTPGxxxxxxx xxxx---------------------------------------------- ---------------------------xxxxxxx---------------- --------xxxxxxxxx--------------------------------- -------------------------------------------------- ------------------xx---------------------------xxx xxx----------------------------------------------- --------------------xxxxx------------------------- ---------EPPTTLL-----------------QSSPxxxx--------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxx----------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------------xGGLRA PNP--------------------------------------------QM- LAPRLPQTSTGQ-P-SV--HNIQLPP---GMVLVRSESGQLLMIPQQALA QM------------------------xxxxx------GGMAPRPSTPTNM -PL-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----PLGNTIISRQ-VSQ--SAISRQSCPAPAPLT-ASTTLHRPPI---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxx-----xxxxxxxxxx--------------- -------------VGxxxxx------------------------------ ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETLENVKKCKNFLATLIKLASSGKQSSETAASVRELIK ELLEGKVEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQHP------------QAASGP-----------VSSSSx--------- -----ST-----------------------------------------VV Q------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------TNKPG---------------------------xPTPL xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xVPAxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxxxxxxxV FAAALT-------------------SAQR--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDEAFLSCAVLQRRMLEISKRHGVTDLGTDVVTFISHATQQRLQN LLEKVSFVAQQKNINLK-ESENYEQSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRKxLDSP--------------S SSASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGSSLMGGAGS-------- -------SSSRP-TRQRITRVNLRDLLFCLEDERFTSRSHFLYKGFLK-- >ENSORLP00000016972 -------------------------------------------------- ------------------------------------------xx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxxxxxxxx--------------------------------- ------------xxx--xx--------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVG- -------------------------------------------------- -------SNSAQTFNGSQ-TMNNH-------------------------- xxxxxx-------------------------------------------- ----------------xxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxx---------------------------------- -------------------------------------------------- ------------------------------xxxx-xxxx----------x xxxx--------------SS-------xGVIQAPx--------------- ----------------------------------------LNSDxx---- -----------xxxxxxQxx------------xxxx-------------- ---------------------------GHTVTLIR-QPMQTPGxxxxxxx xxxx---------------------------------------------- ---------------------------xxxxxxx---------------- --------xxxxxxxxx--------------------------------- -------------------------------------------------- ------------------xx---------------------------xxx xxx----------------------------------------------- --------------------xxxxx------------------------- ---------EPPTTLL-----------------QSSPxxxx--------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxx----------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------------xGGLRA PNP--------------------------------------------QM- LAPRLPQTSTGQ-P-SV--HNIQLPP---GMVLVRSESGQLLMIPQQALA QM------------------------xxxxx------GGMAPRPSTPTNM -PL-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----PLGNTIISRQ-VSP--SAISRQSCPAPTPLT-ASTTLHRPPI---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxx-----xxxxxxxxxx--------------- -------------VGxxxxx------------------------------ ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETLENVKKCKNFLATLIKLASSGKQSSETAASVRELIK ELLEGKVEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQHP------------QAASGP-----------VSSSSx--------- -----ST-----------------------------------------VV Q------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------TNKPG---------------------------xPTPL xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xVPAxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxxxxxxxV FAAALT-------------------PAQR--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDEAFLSCAVLQRRMLEISKRHGVTDLGTDVVTFISHATQQRLQN LLEKVSFVAQQKNINLK-ESENYEQSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRKxLDSP--------------S SSASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGSSLMGGAGS-------- -------SSSRP-TRQRITRVNLRDLLFCLEDERFTSRSHFLYKGFLK-- >ENSORLP00015015894 -------------------------------------------------- ------------------------------------------xx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxxxxxxxx--------------------------------- ------------xxx--xx--------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVG- -------------------------------------------------- -------SNSAQTFNGSQ-TMNSH-------------------------- xxxxxx-------------------------------------------- ----------------xxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxx---------------------------------- -------------------------------------------------- ------------------------------xxxx-xxxx----------x xxxx--------------SS-------xGVIQAPx--------------- ----------------------------------------LNSDxx---- -----------xxxxxxQxx------------xxxx-------------- ---------------------------GHTVTLIR-QPMQTPGxxxxxxx xxxx---------------------------------------------- ---------------------------xxxxxxx---------------- --------xxxxxxxxx--------------------------------- -------------------------------------------------- ------------------xx---------------------------xxx xxx----------------------------------------------- --------------------xxxxx------------------------- ---------EPPITLL-----------------QSSPxxxx--------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxx----------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------------xGGLRA PNP--------------------------------------------QM- LAPRLPQTSTGQ-P-SV--HNIQLPP---GMVLVRSESGQLLMIPQQALA QM------------------------xxxxx------GGMAPRPSTPTNM -PL-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----SLGNTIINRQ-VSP--SAISRQSCPAPTPLT-ASTTLHRPPI---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxx-----xxxxxxxxxx--------------- -------------VGxxxxx------------------------------ ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETLENVKKCKNFLATLIKLASSGKQSSETAASVRELIK ELLEGKVEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQHP------------QPASGP-----------VSSSSx--------- -----ST-----------------------------------------VV Q------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------TNKPG---------------------------xPTPL xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xVPAxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxxxxxxxV FAAALT-------------------PAQR--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDEAFLSCAVLQRRMLEISKRHGVTDLGTDVVTFISHATQQRLQN LLEKVSFVAQQKNINLK-ESENYEQSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRKxLDSP--------------S SSASAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGSSLMGGAGS-------- -------SSSRP-TRQRITRVNLRDLLFCLEDERFTSRSHFLYKGFLK-- >ENSOMEP00000021800 -------------------------------------------------- ------------------------------------------xx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxxx-xxx----------------------------- ----------------xxx--------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVG- -------------------------------------------------- -------SYSAQTFNGSQ-TMNSH-------------------------- xxxxxxxxxxxxxxxxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xx-------------------------------------- -------------------------------------------------- ---------------------------VSSGAAx-xxxxxx--------x xxxx--------------SS-------xGVIQTPx--------------- ----------------------------------------LTSDx----- ------------xxxxxQxx------------xxxx-------------- ---------------------------GPTVTLVR-PPMQTPGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxSSTxxxxxxx-------------------------------xxx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPPTTII-----------------QSAPxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxx----x-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA PNP--------------------------------------------QM- LAPRLPQPSPGQ-P-SV--HNIQLPA---GMVLVRSESGQLLMIPQQALA QM------------------------xxxxx------GGMAPRPSTPTNM -PL-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----SPGNTIISRQ-VSP--TTIIRQTCPTPTPLT-ASTTLHRPPI---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xx---------xxxxxxx--------------- -------------AGxxxxx------------------------------ ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETLENVKKCKNFLATLIKLASSGKQSSETAASVRELIK DLLEGKVEAEEFTSRLYKELNSSPQPYLVSFLKRSLPALRQLTPDSAAFI QQSQHP------------QPASGP-----------ASSSSCSS------- -----ST-----------------------------------------VV Q------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------TNKSG---------------------------xTVPL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------- xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xVPAxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxxxxxxxA FAAALT-------------------PALR--------------------- --------------------------NKLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDEAFLSCAMLQRRMLEIGRKHGVTDLGADVVTFISHATQQRLQN LLEKVSLVAQQKNINIK-ESENYEQSSDVRAQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK E------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxPALL SGRxxxxxxxxxxxxxxxxxxLxxxxxxxxxxxxxxxxxxx--------- -------------------------------------------------- -------------------------------------------------- >ENSLBEP00000021454 -------------------------------------------------- ------------------------------------------MAVGFGPL GEPLVHTEVNKAVIYxxxxxxxxxxx------------------------ -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxxxxxxx-------------------------x---------- -------------------------------------------------- -------------------xx----------------------------- ---------xx--------------------------------------- -------------------------------------------xxxxxxx xxASxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GEIG- -------------------------------------------------- -------SYSVQTLNGNQ-xxx---------------------------- -------------------------------------------------- xxxxxxxxxx---xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------AMNSGPVx-xxxxxx--------x xxxx--------------SS-------xSVIQTPx--------------- ----------------------------------------MNSQx----- ------------xxxxxQxx------------xxxx-------------- ---------------------------GATVALVR-PPMQTVGxx-xxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxVANAxxQTGN----------xxx-----------------IxLVx xx------xx----xxxxxxxxxxx------------------------- ---------EPPTTIV-----------------QSAPxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxV----xxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------AGIRA LSP--------------------------------------------QM- LAPRLPQTSPGQ-P-SIGxHNIQLPP---GMMLVRSESGQLLMIPQQALA QMxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------xxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASTGKHSEETAASVRELVK DLLEGRLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSTAFI QQSQLP------------QPTSAP-----------ASSTSPTP------- -----NT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- ------------TVNKPG---------------------------xTPSM -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xxxxxxxxx--- -------------------------------------------------- -------------------------------------------------- -----------------xxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------D------------- ------------------EDDINDVASMAGVNLSEESANILATNSGLVGA VTHSCKDEAFLSCAVLQRRMLEIGRRYGLTDLGAEVVNFVSHAAQQRLQH LLEKVSQVAQQKNVHFK-EDNNYEQNSDVRTQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRKxLDSP--------------S SSS----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSGPSVPGAAGS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSCGOP00000018779 -------------------------------------------------- ------------------------------------------MAVGTGPL GEPFSHTEVNKVIVCxxxxxxxxxxx------------------------ -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxxxxxxx-------------------------x---------- -------------------------------------------------- -------------------xx----------------------------- ---------xx--------------------------------------- -------------------------------------------xxxxxxx xxASxxxxxxxxxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GKVG- -------------------------------------------------- -------SHSVHTFNGSH-TMNSH-------------------------- xxxxxxxxxxxx-------------------------xxxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------SS-------xSVIQTPx--------------- ----------------------------------------MNSQx----- ------------xxxxxQxx------------xxxx-------------- --------------------------xGATVTLVR-PPVQTAGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xx-------------------------xxxxxxxxxxxxxxxGIQTxLVx xx------xxxxxxxxxxxxxxxxx------------------------- ---------EPPTTII-----------------QSAPxx----------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxx---------------------xxxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxV----xxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA LTP--------------------------------------------QM- LAPRLHQTSPGQ-P-SI--HNIQLPP---GMVLVRSESGQLLMIPQQALA QM--------------------------xxx------GGMAPRTATPTNV -LP-------xx---xxxx------------------------------- ------------xxxxxxxxxxxxxxxxxxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxx---------------------------xxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASSGKQSTETAASVRELVK DLLEGRLEAEEFTSRLYKALNSSPQPYLVPFLKRSLPALRQLTPDSATFI QQSQLP------------QPASGP-----------VSSTSPIP------- -----TT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------ISKPG---------------------------xTPSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPGxxxxxxxx-------- ----------------------------------------x--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- -------------------------------------------------- ------------------------------------x------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEENANILATNSGLVGA VTHSCKDEAFLPCAVLQRRMQEIGKRYGVTDLGAEVVNFVSHATRQQLQN LLGKVSQVAQQKNSTFK-EDDNYEQSSDVRAQLKFFEQLDQLEKQQKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRKxLDSP--------------- xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTGPSLSGGAGS-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSHSHFLYKGFLK-- >ENSPMGP00000017796 -------------------------------------------------- ------------------------------------------x------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxx-xxxxxx-xxxxx--------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------EKVD- -------------------------------------------------- -------TLSVQTLNGSQ-SMNSH-------------------------- xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxxxxxxxxxxxxxx-------------- -----------------xxxxxxx-------------------------- -------------------------------------------------- ---x--------------SS-------xSVIQTSx--------------- ----------------------------------------LNSHx----- ---------------------xxxxxxx----xxxx-------------- ---------------------------GATVTLVR-PPMHI----xxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxVTx----xGI---------------------------SLQTxQxx xxxxx------xxxxxxxxxxxxxx------------------------- ---------EPATTII-----------------QPPPxx----------- -------------------------------------------------- -------------------------------------------------- -------xx---------------------------xxxx---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxL----xxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGVRT LSP--------------------------------------------QM- LAARLPQPTSGQ-P-SV--HNIQLPP---GMVLVRSDSGQLLMIPQQTLA QM------------------------xxxxx------GGLAPRAATPTNM xxP-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----TPGNAVISRP-VTP--STVIRPGGPVSTTLP-KTTTLHRPHI---- ---L-------------------x-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETMENVNKCKNFLSTLIKLASTGKQSTETAACVRELVK DLLEGRLEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQGQLP------------QSSSGP-----------ASTTS---------- ------T-----------------------------------------VI L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------VTKPG---------------------------xSPSL xxxxx--------------------------------------------- -------------------------------------------------- -----xx------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------T xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPSxxxxxxxx-------- ----------------------------------------xQxxx----- ---------------------------------------xxx-------- -------------------------------------------------- -------------xxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------AD------------- ------------------DDDINDVASMAGVNLTEESANILATNSSLVGS VTHSCEDEAFLSFALLQRRMLEIGRRHGVTDFGTDVVKLVSHATQQHLQN LLEKVTQVAQQKNISFK-DNDNYDQSSDVRAQLKFFEQLDQLEKQRMEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKFK EMQQQELAQMRQREANLTALAAIGPRKKRKxGDFS--------------S SSSVSE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGTASSASGGASA-------- -------SGSRP-TRQRITRVNLRDLLFCLENERFTSRSHFLYKGFLK-- >ENSHCOP00000019483 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------MNCH-------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xx-----------------------xx-xxxx-xxxxxxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- ---x--------------LS-------xTVIHTPx--------------- ----------------------------------------PNPQx----- ------------xxxx---------------------------------- ---------------------------APTVTLVR-PPMQTVQxxxxxxx xxx----------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGMQT LTQ--------------------------------------------QI- LSPRLPLTSTGQ-P-GI--HNIQLPP---GMVLVRSEAGQLLMIPQQALA QM------------------------xxxxx------GGAASRTAAP-xx -TP-------xQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----VPGNAVISRQ-TSP--SAIIRQGCPTPASLP-STTALHRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxx---xxxxxx--xxx--------------- -------------AGxxxxx------------------------------ ----------------------------------xxMS--x--------- -------------------------------------------------- ------------ETMENVNKCRNFLSTLIKLTCTGKRFSE-AASVKQLVK DLLENKLEAEEFTSRLYKELNSSPQPYLVPFLEKNLPALRQLTPDSAAFI RQSQLA------------QPASAS-----------VSSTSASP------- -----AA-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------VSKPG---------------------------xTTSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxx-Rxxxx-x-xxxxxx--xx-xxxxxx-xAPGxxxxxxxx-------- ----------------------------------------xQxxxx---- --------------------------------------xx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx-----------xxxxxxxxxxxN SAAVLT-------------------LAQK--------------------- --------------------------DRLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESANILATNSGLVGA VTRSCKDEAFLSCAMLQRRMLEIGRRHGVTDLGPEVINYVSHATQQRLRD LLERVSLVAQQKNGNFK-EEDNHEQSSDVRSQLKFFEQLDQLEKQRKEEQ EREILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANQTALAAIGPRKKRKxLDSP--------------S STAATE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------xxxPNLSGGAGS-------- -------AGSRP-TRQRITRVNLRDLLFCLENERCTSSASFLYKGFLK-- >ENSGMOP00000018451 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -TQ--------------------------------------------QL- LAPRLPQTPAGQ-P-NL--QNFQLPP---GMVLVRSESGQLLMIHQQALA QM------------------------xxxxx----------PRPATPTAM -PL-------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGIPMSSRP-MGP--GSMVRQASP----xA-PTTTLHRPPV---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xx--x--------- -------------------------------------------------- ------------ETMENVKKCRNFLSTLIKLASTGKQSAQTAENVKELVK ELLEGKLEAEDFTSKLYSELNSSPQPYLVPFLKRSLPALRQLTPNAALFA QQSHVP------------QPT---------------xxTPPSP------- -----AT-----------------------------------------VV L------------------------------------------------- -------------------------------------------------- ---xxx--------xxxxxx------------------------------ --------------xxxxxxxxx---------------------x----- -------------ISRPG-------------------------------- -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------P xxx-Axxxx-x-xxxxxx--xx-xxxxxx-QSPGxxxxxxxx-------- -------------------------------------------------- -----xxxxxxxxxxxxxxxx---------------xxxx---------- -------------------------------------------------- ----------------------------------------------xx-- -------------------------------------------------- -----x-------------------------------------------- --AAAS-------------------LAQK--------------------- --------------------------NQLKEA-xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------EDDINDVASMAGVNLTEESARILATNSELVGA VTRSCKDEAFLSTAVLQRRMLEIGKKFGVSELGVDVGTFVSHATQQRLQN LLEKVTQVAQHKNFSFK-EESSYEGSSDVRAQLRFFEQLDQLEKQRKEGQ ERQILLKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAMMRQKEANLTALAAIGPRKPRKxADAS--------------A SAGAAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSGSSL--GAGS-------- -------SGSRP-TRQRITRINLKDLLFCLETERPTAHSQFLYKGFL--- >ENSPNAP00000027332 -------------------------------------------------- ------------------------------------------MAAGPELL DDVFFNAEVDEKTVSDVVGSLESQLIGAG--------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxx-----------------x------------------------ ---------------xx------------xxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- ------------------------------------------------xx xxxxxx-------------------------------------------- ---------------------------------------------GQRG- -------------------------------------------------- -------TSAVTSLNGSNVLVNSH-------------------------- -------------------------xxxxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxx---------------------------------- --xxxxx------------------------------------------- -------------------------TVVNNGPG---------xMxxxx-- --xx--------------xS-------xTVIQTSx--------------- ----------------------------------------MN-----xxx -------------xxxxxx------------------------------- ----------------------xxxxxGPTVALVR-PPMQT--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- ----xx------xxxxxxxxxxxxx------------------------- ---------DSTKTLI-----------------QTVAxx----------- ------------------------------------------------xx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xRGPx-------------xxx---------- ---------------------------xSRTPVPAAV----Gxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGIRA IAP--------------------------------------------QV- LAPRVPQPQQSQ-P-SV--HNIQLPP---GMVLVRSESGQLLMIHQQTLA QM------------------------xxxxx------GAMATRPTTPTST -PPV--HITSVQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGTSLITRQ-VAP--TTIIKQASPVPAPVQ-PTTALQRPPL---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxGxxx xx-----------------------------------xxxxx---xxxxx xxxxxxxxxxxx------xx------------------------------ ----------------------------------xxAT--x--------- -------------------------------------------------- ------------ETLENVKKCKNFLSTLIKLASSGKQSSETAANVKELVK NLLEGKLEAEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQMTPDSVAFI QQSQLQ------------QPS--------------xxxSSTAL------- -----TA-----------------------------------------AV Lxxxxxxx------xx---------------------------------x xx------------------------------------------------ -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxx--------xx--------------VISLSQ------- -----------NAPSKPNx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xx- ---------------------x---------------------------- -------------------------------------------------- ----------------------------------x--------------x xxxxGxxxxxx-xxxxxx--xx-xxxxx---------------------- -------------------------------------------------- ---------------------------------------xxx-------- ------xxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxxxxxxx--------------------------- -------xxx---------xxxxxxAVQK--------------------- --------------------------TKLKDAxSGSF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESDRILATNSELVGV VTRSCKDEPFLYTGSLQRRILEIGKKYGITEVGSDVISIVSHAAQQRLQN LLEKVTQVAQQKNVPYK-EDERHEQISDVRAQLKFFDQLDQMEKQKKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQMRQRDANLTALAAIGPRKKRK-MDTS--------------A GGSGPE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GVSSVSAGSVAAGS-------- -------GGSRQFPRQRITRVNLRDLLFCLENERETSHSHLLYKAFLK-- >ENSAMXP00000002973 -------------------------------------------------- ------------------------------------------MAAGSELL DDVFFSAEVDETAVSAVVGSLESQLIGPG--------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------xx----------------- -----xxxxxxxxxxxxxxxxxxxxx------------------------ ---------------xx------------xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxx-------------------------------xxxx---- ---------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------VNNGPG---------xVxxxx-- --xx--------------PS-------xTVIQTSx--------------- ----------------------------------------MN-----xxx -------------xxxxxx------------------------------- ----------------------xxxxxRPTVALVR-PPMQT--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xxxxxxxxx-------xxxxxxxxxxx---- -------------------------------------------------- -------------------------------------------------- ---------------xxx---xxxxxxxxxxxxxxxxxx----------- ------------------------------------------------xx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xRGPx-------------xxx---------- ---------------------------xGRTTVPGAV----Axx---A-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GAIRA IAP--------------------------------------------QV- LAPRVPPPQQNQ-P-SV--HNIQLPP---GMVLVRSESGQLLMIHQQTLA QM------------------------xxxxx------GAMAPRPTTPTST -PPV--HITSVQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGTPLITRP-VAP--TTIIKQSSPVPAGVQ-PTTALQRPPI---- ---L-------------------Q-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ETLENVKKCKNFLSTLIKLASSGKQSSETAANVKELVK NLLEGKLEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSVLFI QQSQ---------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxx-----xxxxx---------------------------------- -----x--------xxxxxxxxxxxxxxxxxxxxxxxx------------ --------xxxxx--------xx--------------IASLPQ------- -----------HTHSKPNx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xx------------- -----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------- -------------------------------------------------- -------------xx----------------------------------- ---------------------------------xxRD------------- ------------------DDDINDVASMAGVNLSEESDRILATNSELVGA VTRSCKDEAFLYTGALHSRILQIGKKFGISELGSDVVSIVSHAAQQRLQN LLEKVTQVAQQRNVPYK-EDERHEQVSDVRAQLKFFEQLDQMEKQRKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQMRQRDANLTALAAIGPRKKRK-VDSP--------------A SGSGPEx------------------------------------------- ------------------------------------xxxxxLLVxxxxxx -------------------------------------------------- ---------------------------x---------------------- -------------------------------------------------- ----------------------------------------xS-------- -------GGSRQFSRQRITRVNLRDLLFCLENERDTSRSHLLYKAFLK-- >ENSDARP00000103064 -------------------------------------------------- ------------------------------------------x------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------xxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xG- -------------------------------------------------- -------TSTVQTLNGGN-AMDPH----------x--------------- xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxx-------------------------------------- ---------------------------xxxx------xxxxxxxxxxx-- ------------------------VPVVNNGPGx-xxxxxx--------x TVAP--------------SP-------NTVIQSSx--------------- -------------------------------------------------- -----xxxxx---------------------------------------- ------------xxx----------SAGPLVTVVR-PSMQTAGxxxxxxx xxx----------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xx------------------------- ---------ESPKTII-----------------Q---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxQV- LAPRLPQSSPGQ---NI--QNIQLPP---GMVLVRSDSGQLLMIPQQMLA QL------------------------QAQTQSA---------xxxxxxxx -xxx--xxxxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGTPLMARQ-VTP--TTIIKQGSHTASS-T-ATTTLQRPPV---- ---Q-------------------Qx------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxxxxxxxxxxxxxxxx--------------- -------------xxxx--------------------------------- ----------------------------------xxxx--x--------- -------------------------------------------------- ------------ETMENVKKCRNFLSTLIKLATSGKQSSETVANVKELVK NLLEGKIEAEEFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSTAFI QQSQAx------------x------------------------------- --------------------------------------------xxx-VV L------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxx----------------xxx-------------- ---------------------xx---------------------x----- ------------------------xxxxx----------------xxxSL -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------x xxx-xxxxxxx-xxxxxx--xx-xxxxxx-xPHSxxxxxxxx-------- ----------------------------------------xxxxxx---- -------------------------------------------------- ------------------xx---------x-------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxx---------- xxxxxx-------------------AAQK--------------------- --------------------------NKPKDGAGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------RD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGA VTRSCKDEAFLSASMLQHKILEIGQRFGVTDLGPEVVNIVSHATQQRLQN LLEKVSLIAQQKNMTYK-EDSRYEQVEDVRAQLKFFEQLDQLEKQKKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQRDANLTALAAIGPRKKRK-PDSP--------------S LGIDTE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGLCASASGGLNA-------- -------GASRQFTRQRITRVNLRDLLFCLENEKSTSHSQLLYRALLK-- >ENSIPUP00000035460 -------------------------------------------------- ------------------------------------------x------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------xxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------VKLG- -------------------------------------------------- -------TSTVQTLDGGD-AMDPR----------x--------------- xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxx-------------------------------------- ---------------------------xxx---------------xxxxx xxxxxxxx---------------TVPVVNNGPGx-xxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxx---------------------------- xxxxx--------------------------------------------- ----x-----------------xxx------------------------- ---------ESPQTVI-----------------QSAxxx--------xx- -------------------------------------------------- ----x--------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxx---A-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------GGVRT IAPx-------------------------------------------xV- LAPRLPQSTPGH-P-SI--HNIQLPP---GMVLVRSEAGQLLMIPQQVL- ---------------------------xxxxxx---------xxxxxxxx -xxx--xxxxTQ---------------------------HVTD------- --------------------------------------GxxxLxxxxERE RESEKETExxxxxxxxxxxETEREGERETESERERVRGREEMxxxxxxxH DxxxTPGATIMARP-VTP--TTIIKQGSPTTSS-T-TAPTLQRPPV---- -----------------------xx------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxxxxxxxxxxxxxxxx--------------- -------------xxxx--------------------------------- ----------------------------------xxxx--x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLATSAKQSSQTAANVKDLVK NLLEGTIEAEDFTSRLYKELNSSPQPYLVPFLKRSLPALRKLTPDSLAFI QQSQGL------------QP------------------------xxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----- -------------------------------------------------- -------------------------------------------------- --------------xxx----------------xxx-------------- ---------------------xx---------------------x----- ------------------------xxxxx----------------xxxSx -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------S xxx-Gxxxxxx-xxxx-x--xx-xxxxxx-xPHSxxxxxxxx-------- ----------------------------------------xQxxxx---- -------------------------------------------------- ------------------xx---------x--------------xxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- ----xx-------------------xx----------------------- --VAFN-------------------AAQK--------------------- --------------------------NKLKDAxGGTF------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KD------------- ------------------DDDINDVASMAGVNLSEESARILATNSELVGA VTRSCKDEAFLFSAALQRRILDIGKRFGVTDLGPEVVNLVSHATQQRLQN LLEKVTVIAQQKNMNYK-EDARFEQMTDVRAQLKFFEQLDQLEKQKKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQRDANLTALAAIGPRKKRK-LDSP--------------A LGTDAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSSASSSAGLSG-------- -------GASRQFTRQRITRVNLRDLLFCLENEKESTRSQLLYRALLK-- >ENSPNAP00000027322 -------------------------------------------------- ------------------------------------------x------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------xxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------VKTG- -------------------------------------------------- -------TSTAQTFGGGD-AMDAR----------x--------------- xxxxxxx------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxGxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx-------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------GVRA IAPx-------------------------------------------xV- LAPRLPQSSPGQ-H-SI--QNIQLPP----MVLVRSESGQLLMIPQQVLA QM------------------------QAxxxxx---------xxxxxxxx -xxx--xxxxAQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxTPGAPIMTRQ-VAP--x-IIKQGPPTASS-T-ATTTLQRPPV---- -----------------------xx------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -----------------xxxxxxxxxxxxxxxxxx--------------- -------------xxxx--------------------------------- ----------------------------------xxxx--x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLATSAKQSSQTAANVKELVK NLLEGTIEAEDFTSRLYKELNSSPQPYLVPFLKRSLPALRQLTPDSLAFI QQSQGx------------x-------------------------xxxxxx xxxxxSTx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------x xxx-Gxxxxxx-xxxxxx--xx-xxxxxx-xPHSxxxxxxxx-------- ----------------------------------------xQxxxx---- -------------------------------------------------- ------------------xx------------------------xxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- ----xx-------------------xx----------------------- --VTLI-------------------AAQK--------------------- --------------------------SKLKDAxGGTx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------D------------- ------------------DDDINDVASMAGVNLSEESARILATNSDVVGA VTRSCQDEAFLSSALLQRRILDI-KRFGVTDLAPDVVNLVSHATKQRLQN LMEKVSVIAQQKNMTYK-EDGRFEQVTDVRAQLKFFEQLDQLEKQKKEEQ EREILMKAAK----------------------SRSRQEDPEQLRLKQKAK EMQQQELAQIRQRDANLTALAAIGPRKKRK-LDSP--------------A LGTDAE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSGSSASMTVGLSG-------- -------GVSRQFTRQRITRVNLRDLLFCLENERASSRSQLLYRALLK-- >ENSCHAP00000056366 -------------------------------------------------- ------------------------------------------MAVDPELL DAVLSNTEVDHKVVSIIVGSLDWEIRQTG--------------------- -------------------------------------------------- ---------------------------------------x---------- ---------------------------------------x---------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxxxx--------------------------------------- --------------------------------------xxxx-------- -------------------------------------------------- ------------------------------------------xxxx---- -------------------------------------------------- ----------------xx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxxxxxx----------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxx---------------------------------- -------------------------------------------------- ---------xxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xP-------NIVIRT--------x-------- ----------------------------------------xNSQxxxLSx -------------------------------------------------- ----------------------xx-xxGATSVTIR-PPVQMGxxx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxx--xxxxxxxxx-------------- ------------------xxxxxx-------------xxx---------- ---------------------------xTRTVSPTAV----Axxx--xxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------------xSGVRA IAP--------------------------------------------QV- FAPRLPQPGPNP-PxNV--QNIQLPP---GMVLVRNQSGQLLMMHQQTLA QM------------------------QAQAKSx----SAMAPRPSTPTIS -TP-------IK-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APGTPIVARH-MAP--LTVTKQGSPTPVSAP-ATTTLQRPPI---- ---L-------------------Q-------------------------- -------xx--------------xxxxxxxxxxxxxxxxxxx-------- -------------------------------------------------- --xxx---------------------------xx---------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLACSGKQSTETAANVKDLVR KLLEGKIEPEDFTGRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSAAFI QQSQGL-----xx-----xxxx---xxxxxxxxxxxxxxxxxx------- -xxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- --xxxx-------------------------------------------- -----------------xxxxxx--------------------------- -----------------------------------------------xxx -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------A xxx-Gxxxxxx-xxxxxx--xx-xxxxxx-xPQNxxxxxxxx-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------x-------------------------------------- -------------------------------------------------- -----------------------------------------------xx- -------------------------------xxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------GD------------- ------------------DDDINDVASMAGVNLSEESARILAINSDLAGT VMRSCKDEAFLHTPMLTRRIAEIGKKYGIAELGPELVTFVSHATQQRLSS LLEKASVVAQHKNANFK-EGNHYEQASDVRLQLKFFEQLDQMEKQRKEEQ EREILMKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAEIRQREANLTALAAIGPRKRKK-MDSPx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xSGASCSSSASSGS-------- -------GASRQFTRQRITRINLRDLLYCLENEHSSSHSQLLYRGLLK-- >ENSDCDP00000038070 -------------------------------------------------- ------------------------------------------xx------ -------------------------------------------------- -------------------xxxxxxx------------------------ -------------------------------------------------- ---------------------------------------xx--------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxx----------------------------- ---------xxxx------------------------------------- -------------------------------------------------- --------------xxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxx-----------------------x-------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------VAVAR-APFQAAG------- -------------------------------------------------- -----------------------xx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxx---------------------------------x------------- -------------------------------------------------- -----------xxxxx-xxxxxxxx-------xxxxxxxxx--------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxx------------ -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxx---P-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------AAVRT MTP--------------------------------------------QVx LTPRLPQPAPSQ-P-SI--SNIQLPP---GMVLVRSETGQLLMMPQQVLA QL------------------------xxxxx------NAIAPRPANPIST --------xxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ----APSSPIVPRQSVTP--VAIAKQGAITASSMS-ATPTTHRPPV---- ---L-------------------Q------------------------xx xxxxx--------------------------------------------- ------------------------------------------xxxxx--- -------------------------------------------------- -----------------xxxx--xxxxxxxxxxxx--------------- -------------xx----------------------------------- ----------------------------------xxVS--x--------- -------------------------------------------------- ------------ETMENVKKCKNFLSTLIKLASSGKQSSETAANVKELVK KLLEGRVEAEDFTSSLYKELNSPPQPYLVPFLKRSLPAVRQLTPDSMAFI QQSLTP------------AQPQKP-----------TASVSx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------xxxxxx--------------------------- -----------------------------------------------xTx -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -----------------------------------------------x-- ---------------------x---------------------------- -------------------------------------------------- -------------------------------------------------T xxx-Gxxxxxx-xxx-xx--xx-xxxxxx-xPPSxxxxxxxx-------- -------------------------------------------------- -----xx-------------------------------xx---------- -------------------------------------------------- -----------------------------------------xx------- -------------------------------------------------- ----xx-------------------xx----------------------- -------------------------------------------------- -------------------xxxxxx--------xxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------x-------------- ------------------DDDINDVASMAGVNLSEESARILATNSDVVGA VTRSCGDKAFLYSTALQRRILEIGRRKGITELGPDVVNFVSHAAQHRLRD ILERVSTIAHHKNVAFK-EDGKHEQTDDVRLQLKFFEQLDHVEKQRKEEQ EREILMKAAK----------------------SRARQEDPEQLRLKQKAK EMQQQELAQMRQREANLTALAAIGPRKKRK-VDSL--------------G GGAGTE-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------GSLSTSLSVSGAGT-------- -------GPARQFTRQRITRVNLRDLLVCLENERSTCHSQLLYRALLK--