>ENSAPOP00000032040 -------------------------------------------------- -----MG-------------------KKRRSEDS-SESNTPLKKEKV--- ------------------PEFNGTVFKAMLKDPTTAKK------------ -------------------G------------------------------ -----------------------------------------------LQT FISTAKKLPCSDLYDVVEGYIKISMECAEIFKLLEGEKHMENEMVVIFES LEVILLRTASDLSHFNMVGNAIVKKIVSSHMKLLQSSFNSENHRFVRQCL SLLSALVSQGPEAAREVLTHIHINKSLSGLAKRKDKKGRPDVRQAFIQFV LSFLVSGDNAAVGQILEMKELLPEILNTGLREDRMSTVNLILSTLKTRVV LNKAISKTQKVRFFTPAVLANIASLYKWNGIVDMVKxx---------ELA GISVVWDLVHSFLLDLCCSRKHGISFHDASFGTVGRAGNIVLLQFLVGLK QATEDELVAELVVNVLKESPDILSRYFKETQYSYTPRLKSAWQDNVKLLK KIYEAQPEISTVFQTHDLIPVPRLLSMIMVISLPPVCNKAFFTQGLSV-- ----------------------------------------TVQLTTLSMV NFLLKRAHKNMEYLLDKSVWSNSDLYTLDMMEDVVQQYRETLSKILPDMT CIVEKWQS-----------------------------LSKKE-------- -------------------------KTDGEEKKMQTEGSAxxxx--x--- -------------------------------------------------- -----------------------xxx-----------AEVILLKALILQV ICLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMREEVPPVLQYQ ILQLALDLPASKFSWFRI-------------------------------- ---------QDIADT----D-SASGEKSVLYLLLKMFV-SSSxSSHLKTS TQTLVQKVLKDTGMFEHTWTELELWLDHLIRLDPNQQETCIQFLEKVLVK VVCNSYTYTDKVASLVQEAGYLQANLSSQEGDAASIPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGNDGEMEEFGPSLSEDLIIQTFPFSVVVPAALESRNK L-----------P----ADK-------G--------VVCEYLSAVLSDVL HCQRDPLPLCLALLHYDKELVS-SELSAPPNP---AIIHFHQYYSKWLPQ QCHEEL-------------------------------------------- -----------FKS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SECHSKGLPTPTSCT-------------ALMKAA YIQGANT----------------LLEHAFRENVEGALSSMSVTEFPIAIK QVLLYIKSTVENFG---------T-------------------------- -------------------------x------------------------ -----------------------AAxKSQ--------------------- -----------------------EGSDL-----------FLELNQLTPVE -------------VNKEQILVSALGSIFKHPCLGQWFLALELSALPPHSL NPARLKQLCAQLTDGILALLKISAPTLRDLNHLELLCSYMEAIERSVLKE L--------TEK----GSQPAKTHSRPFQALLSLHSYMGSCNLKEVVSKL LLLSHSSLIS----------P-SSEGTQSELSNYGHAALQILTESKSTSS QDQD--TFLTQ--------------------------------------- ---AHFHGLGTLLLSCTSPALEAFLLHTLSHEPGSAKLIHTDVLLHCL-- ------Q----RPLNDTLAISSLLLQNSSAHCLCFEVWCLE--------P ANMEKLSDQITAY---LPLINAYLQLAGREDPARPQD------------- -------------------------------------------------- --------------------VQNEVLKAMKQTLLAK-------------- ------------------------------------------------LS QSVLENLSEDSGAQL--AETLSNLIKFSANVKDIRDMISNLP-------- ----NALQNVDSF-E------RWKLVDVITEKLADCPEEQEKWKKSVATA ALKCLIASY-------------------------------SHSKEQ---- --------------ATSPTDQE---------------------------- --------------------------------xxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxHHFLSTLISLLEVMYSDSEVQKDRIPLST LHMMTISHSLFLPTMLASDEE-------x--------------------- --------------------------------------------KELISL LLCLVKKCPSVCNVNHFVILLGAYGATLCTSDQKLLLLLQEYEKKQVSLL KF--Q---------------------------SFLWGPAALEHHKTRKSL GASLWKQASSDDLLALLKTDKMLQTVAHFPQQRRIIPQx----------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxxxxxxxxxxxxxxECVIDCL KFVSSHALGVTVMALSSYDSKVRAAAYHVLSCFYQHLEGARFREKRQLLY LMDIVKN------------------------------------------- ---------------------GIRQQNQRLPFVLTTYITKAAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYGFDL----------------- -----------EHKMEREWILTVLEEGISDGHCYQLCNQQGIFQILLGFS SSPLCDERFQ-------AQVVRVLCQAVRVTKAAYNLIKSSGLLAWIIQV VEK-RNL----EQQLLCAIIDLFHVLWFTNLGQK-------------E-K Q--ADEAK-ACSSTEEKPQSL--------------------------VKC LPLPLISEFLCVASTISRHL-R---LGVKATQLKLFLQTLCSVLKH---- ---------RETALNVNKQADRLTLRPQSLSCTETLSLLLCWASL----- ------------SRNTTLLTQIQDLSEKHKVKEL-----M---------- -------------------------------------------------- ---------------xxxxxxxxxx------------------------- -------------------------------------------------- ---------------------------x--------EDTE---------- ----------------------MEKHEESL---------LTECRFYLSSI FVHLEPVLP----------------------------------------- -------------------------------------------------L TEPRPSQPKDKLDPSRLASDSVHLLTKW--------------------SL KWLVE--DSYDENRAKEFLHWLEKAVLKHKEAVDVVLLDHSLKADLLRFY HQ------------xx----xxxx-------xxx----xxRAETFQLYTN IMM------------------GFLDTQG-HLPE--L-------------- -----------------HRA----------------------VVSA---- ----------CMPKATH-DQSRL-E--------AG--------------- ------------LSLLSLYTHELWSGATSAELFLSHVNLV---------- ----TRTKC-KK---------------------------QKASKS-SxTP TAI----------------------RAIC-----------NDIITMK--- --------S----- >ENSSPAP00000009151 -------------------------------------------------- -----MG-------------------KKRRSEDS-AESNTPAKKEKA--- ------------------PEFNGTLFKAMLKDPTTAKK------------ -------------------G------------------------------ -----------------------------------------------LQT FISTAKKLPCSDLYDVVEGYIKISMECAEIFKLLEGEKHNENEMMPVFES LEVILLRTASDLSHFNMVGNAIVKKIVSSHMKLLQGSFNSENHRFVRQCL GLLSALVSQGPEAAREVLSHIYINRSLSGLAKRKDKKGRPDVRQAFIQFV LSFLVSGDNAAVGQILELKELLPEILNTGLREDRMSTVNLILSTLKTRVV LNKAISKTQKVRFFTPAVLANIASLYKWNGIVDATTDDDR--x----ELA GISVVRELVHSFLLDLCCSRKHGISFHDASFGTVGRAGNIVLLQFLVGLK QATEDELVAELVVNVMKASPDILSRYFKETQHSYTPRLKSAWQDNVKFLK KIYEAQPEISTVFHANELIPVPRLLSMIMVISLPPVCNKVFFTQGLNV-- ----------------------------------------TVQLTTLSMV NFILKRANKNMEYLLDESVWSNSDLYTLDMMEEVVQQYRETLSKILPDMT KIIEKWQS-----------------------------LSKKE-------- -------------------------KTDGEEKKTQTEGNTxxxx--x--- -------------------------------------------------- -----------------------xxx-----------AEVILLKALILQV ICLYQKVVPHLVSQCKFDFSKLFK-------------------------- -------------------------------GIVSDKGMREEVPPVLQYQ VLQLALELPASKFSWFRI-------------------------------- ---------QDIADS----E-SSSGEKSVLYLLLKMFV-SSSxSSHLKTS TQMLVQKVLKDTGVFEHTWTELELWLDHLTRVDPNQQETVIQFLEKVLVK VVCSSYTYTDKVASLVQEAAHLQANLSSQEGDAASIPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGNDGEMEEFGPSLSEDLIIQTFPFSVVVPAALESRNK L-----------P----ADR-------G--------VVSEYLSAVLSDVL HCQRDPLPLCLALLHYDKELVS-SELSASPNP---AIIHFHQYYTKWLPQ QCHEEL-------------------------------------------- -----------FKS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SECHSKGLPTPTSCT-------------ALMKAA YLQGANT----------------LLENAFRENVEGALASMSVAEFPVAIK QVLLYIKSTADNFG---------TFSKDVGASLLS---------TLMGIL KDMVTKLQDLKETKN--------SEP------------------------ -----------------------AAxKSQ--------------------- -----------------------EGSDL-----------FLELNQSAPVE -------------VNKEQILVSALGSIFKHPCLEQWFLALELSALPPHSL NPARLKQLCAQLTDGVLAILKISAPVLRDLNHSELLCSYMAAVERAALKE L--------MEK----GSQPAKKHSRPFQALLSLHSYMDSCNLREVVSKL LLLSQSSLIS----------P-SSDGTQSELSNYGHAALQILTECKSASS QDQG--TFLTQ--------------------------------------- ---AHFHGLGTLLLSCTSPALEAFLLHTLSSEPGSAKLIHTDVLLHCL-- ------Q----RPLGDTLAISSLLLQNSSTHCLFFEMWCLE--------S ANIEKFSDQTKTF---LPLINAYLQLADREDPARPQD------------- -------------------------------------------------- --------------------VRNEVLKALKRGLLAK-------------- ------------------------------------------------LS QSVLENLSEDSGAQL--AETLAHLIKISANIKDIRDLINNLP-------- ----NALQNIDSF-E------RWKLVDVITEKLADCPEEQEKWKKSLATA ALKFLIASY-------------------------------SHSKDQ---- --------------AASPSDQEQSILNRL-QQLLVxxxxSAEDIT----- -------------ASEWNSFVKNGLKYRYRDx------------------ ----------------------HFLSTLISLLELMYSGSEVHKDRIPLST LHMMTISHSLFLPTMLASDEEL-SSGLAK--------------------- --------------------------------------------EELISL LLCLVKKCPSVCNINHFVVLLGSYGATLCVSDQKLLLLLQEYEKNQVSLL KF--Q---------------------------SFLWGPAALEHHKTRKSL GASLWKQASSDDLLALLKTDKMLQTVAHFPQQRRIIPQxxxxxxxxxxxx --------------------xx---------A------------------ -------------------------------V------------KDLGNL YDPCFLLP----LFSTILQP-----------------------ECVVDCL KFVSSHALGVTVTALSSYDPKVRAAAYHVLSCFYQHLEGARFREKRQLLY LMDTVKN------------------------------------------- ---------------------GIRQQNQRLPFVLTTYISKAAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYGFDL----------------- -----------EHKMEREWILSVLEEGIRDGHCYQLCNQQGIFQILLGFS SSPLCDERFQ-------AQIIRVLCQAVRVTKAAYNLIKSSGLLTWVMQV VEK-RNL----DQQLLCAIIELLHVLWFTNLGQK-------------E-K Q--ADEAK-ASSSTEEKPQSL--------------------------VKC LPLPLISEFLFVASTISRHL-R---LGVKAAQLRLFLQTLCSVLKH---- ---------RETALNANKQADWLTLRPQSLSSTETLSLFLCWASL----- ------------SRNTALLTQIQALTEKHKVKEL-----M---------- -------------------------------------------------- ---------------xxxxxx----------------------------- -------------------------------------------------- ------------------------------------xDAE---------- ----------------------SEKQEESL---------LTECKFYLSSV FIHWEPVLH----------------------------------------- -------------------------------------------------L TEPQPSQPRDKLDPSRLASDTAHLLTKW--------------------SL RWLVE--DSYDENRAKEFLHWFENAVIKHRETVDAVLLDLGLKADLLRFY HQAFEAQCHSRISG--------------------------RAETFQLFTN IMI------------------RLLETQG-HLPE--L-------------- -----------------HQA----------------------VVSA---- ----------CMPGATH-DQSRLxK--------TG--------------- ------------LSLLSLYIHELWSGATSAELFLSHVNLV---------- ----TKAKY-KK---------------------------PKAVKS-SxTQ TAI----------------------RAIC-----------SDIVTMK--- --------V----- >ENSAOCP00000023868 -------------------------------------------------- -----MG-------------------KKRRSEGS-SESNTPVKKEKV--- ------------------PEFNGTVFKAMLKDPTTAKK------------ -------------------G------------------------------ -----------------------------------------------LQT FISTAKKLPCSDLYDVVEGYIKISMECAEIFKLLEGEKHMENEMMVIFES LEAILLRTASDLSHFNMVGNAIVKKIVSNHMKLLQGSFNSENHRFVRQCL SLLSALVSQGPEAAREVLSHIHINKSLSGLAKRKDKKGRPDVRQAFIQFV LSFLVSGDNAAVGQILDIK---xKILNTGLREDRLSTVNLILSTLKTRVV LNKAISKTQKVRFFTPAVLANIASLYKWNGIVDATTDDNR--x--DSELA GISVVRDLVHSFLLDLCCSRKHGISFHDASFGTVGRAGNIVLLQFLVGLK QATEDELVAELVVNVLKESPDILSRYFKETQYSYTPRLKSAWQDNVKLLK KIYEAQPEISTVFQTRELIGVPRLLSMIMVISLPPVCNKAFFTQGLSLA- --------------------------------------NQAVQLTTLSMV NFLLKRANKNIEYLLDKSVWSSSDLYSLDVMEEVVQQYRETLSKVLPDMT RIVEKWQS-----------------------------LSKKE-------- -------------------------KTDGEEKKMQTEGx----------- -------------------------------------------------- --------------------------------------EAILLKALILQA ICLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMREEVPPVLQYQ ILQLALDLPASKFSWFH--------------------------------- --------------T----E-SASGEKSVLYLLLKMFV-SSSxSSHLKTS TQMLVQKVLRDTGVFEHTWTELELWLDHLIRLEPNQQETCIQFVEKVLVK VVCNSYTYTDKVASLVQEAGYLQANLSSQEGDAASIPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGNDGEMEEFGPSLSEDLIIQTFPFSVVVPAALESRNK L-----------P----ADK-------G--------VVYEYLSAVLSDVL HCQRDPLPLCLALLHYDKELVS-SEPSASPNP---AIIHFHQYYSKWLPQ QCHKEL-------------------------------------------- -----------V-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------TA YIQGANS----------------LLEHAFRENVEGALSSMSMTEFPIAIK QVLLYIKSTVENFGxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------ILVSALSSIFKHPCVDQWFLALELSALPSHSL NPARLKQLCALLTDGILALLKISAPTLRDLNHLELLCSYMEAVERAVLKE L--------TER----GSQPAKTHSRPFQALLSLHSYMGSCNLKEVVSKL LLLSHSSLIS----------P-SSEGTQSELSNYGHAALQILTESKSTSS QDQG--TFLTQ--------------------------------------- ---AHFHGLGTLLLCCTSPALEAFLLHTLSREPGSAKLIHTDVLLHCL-- ------Q----RPLSDTLSISSLLLQNSSTHCLCFEVWCLE--------P ANMEKLSDQTKAF---LPLINTYLQLAGREDPARPQD------------- -------------------------------------------------- --------------------VQNEVLKAMKQTLLAK-------------- ------------------------------------------------LS RSVLENLSEDSGAx------------------------------------ ----------------------WKLVDVITEKLADCPEEQEKWKKSVATA ALKCLITSY-------------------------------SHSKDQ---- --------------ATSPTDQEQSILDRMxxxxxx-----AEGIT----- -------------ASEWNSFVKNGLKYRYRD------------------- ---------------------HHFLSTLISLLEVMYRDGEVQKDRLPLST LHMMTISHSLFLPTMLASDEE-------xx-------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxx-----------------xxxxxSFLWGPAALEHHKTRKSL GASLWKQASSDDLLALLKTDKMLQTVAHFPQQRRIIPQ------------ ---------------------DGMELLYSNNA------------------ -------------------------------V------------KDLGDL YDPCYLLP----LFSAILQP-----------------------ECVIDCL KFVSSHALGVTTMALSSYDPKVRAAAYHVLSCFYQHLEGARFREKRQLLY LMDIVKN------------------------------------------- ---------------------GIRQQNQRLPFVLTTYITKAAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYGFDL----------------- -----------EHKMEREWILTVLEEGISDGHCYQLCNQQGIFQILLGFS SSPLCDERFQ---------x----xTAVRVTKAAYNLIKSSGLLSWIIQV VEK-RNL----EQQLLCAIIDLFHVLWFTNLGQK-------------E-K Q--ADEAK-ACSSTEEKPQSL--------------------------VKC LPLPFISEFLCVASTISRHL-R---LGVKATQLKLFLQTLCSVLKH---- ---------RETALNVNKQADRLTLRPQSLSCTETVSLLLCWASL----- ------------SRNTALLTQIQALSEKHKVKEL-----M---------- -------------------------------------------------- ---------------xxxxxxxxxxx-----------------------x xxxx-------------xx------------------------------- -----xxx-----------------xxx---------------------- -------------------------------------------------I FVHWEPVVH----------------------------------------- -------------------------------------------------L TEPQPAQPKHKLDPSRLASDTVHLLTKW--------------------SL KWLVE--DSYDENRAKEFLHWLEKAVLQHKETVDVVLLDRGLKADLLRFY HQAFEARRHSSISS--------------------------RAETFQLFTN IMM------------------CLLETQG-HLPE--L-------------- -----------------HQA----------------------VVSA---- ----------CMPKATR-DQSRLxKxLSAFSxxVW--------------- ------------LSLLSLYTHELWSGATSAELFLSHVSLV---------- ----SKAKC-KK---------------------------QKASxx-xxTP TAI----------------------RAIC-----------NDIITMK--- --------S----- >ENSAPEP00000015281 -------------------------------------------------- -----MG-------------------KKRRSEGS-SESNTPVKKEKV--- ------------------PEFNGTVFKAMLKDPTTAKK------------ -------------------G------------------------------ -----------------------------------------------LQT FISTAKKLPCSDLYDVVEGYIKISMECAEIFKLLEGEKHMENEMMVIFES LEAILLRTASDLSHFNMVGNAIVKKIVSNHMKLLQGSFNSENHRFVRQCL SLLSALVSQGPEAAREVLSHIHINKSLSGLAKRKDKKGRPDVRQAFIQFV LSFLVSGDNAAVGQILEIK----xILNTGLREDRLSTVNLILSTLKTRVV LNKAISKTQKVRFFTPAVLANIASLYKWNGIVDATTEDNR--x--DSELA GISVVRDLVHSFLLDLCCSRKHGISFHDASFGTVGRAGNIVLLQFLVGLK QATEDELVAELVVNVLKESPDILSRYFKETQYSYTPHLKSAWQDNVKLLK KIYEAQPEISTVFQTRELIAVPRLLSMIMVISLPPVCNKAFFTQGLSLA- --------------------------------------NQAVQLTTLSMV NFLLKRANKNIEYLLDKSVWSSSDLYSLDVMEEVVQQYRETLSKVLPDMT RIVEKWQS-----------------------------LSKK--------- -------------------------KTDGEEKKMQTEGSTxxxx--x--- -------------------------------------------------- -----------------------xxxx-------AETAEAILLKALILQA ICLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMREEVPPVLQYQ ILQLALDLPASKFSWFRI-------------------------------- ---------QDIADT----E-SASGEKSVLYLLLKMFV-SSSxSSHLKTS TQMLVQKVLRDTGVFEHTWTELELWLDHLIRLEPNQQETCIQFLEKVLVK VVCSSYTYTDKVASLVQEAGYLQANLSSQEGDAASIPVSHI--------- ---------A---------------------------------------- --DVLDMLDVIMEGNDGEMEEFGPSLSEDLIIQTFPFSVVVPAALESRNK L-----------P----ADK-------G--------VVYEYLSAVLSDVL HCQRDPVPLCLALLHYDKELVS-SEPSASPNP---AIIHFHQYYSKWLPQ Q------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------SA YIQGANS----------------LLEHAFRENVEGALSSMSMTEFPIAIK QVLLYIKSTVENFGxxxxxxxxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------x-------SIFKHPCVDQWFLALELSALPPHSL NPARLKQLCALLTDGILALLKISAPTLRDLNHLELLCSYMEAVERAVLKE L--------TER----GSQPAKTHSRPFQALLSLHSYMGSCNLKEVVSKL LLLSHSSLIS----------P-SSEGTQSELSNYGHAALQILTESKSTSS EDQG--TFLTQ--------------------------------------- ---AHFHGLGTLLLCCTSPALEAFLLHTLSREPGSAKLIHTDVLLHCL-- ------Q----RPLNDTLSISSLLLQNSSTHCLCFEVWCLE--------P ANIEKLSDQTKAF---LPLINTYLQLAGREDPARPQD------------- -------------------------------------------------- --------------------VQNEVLKAMKQTLLAK-------------- ------------------------------------------------LS RSVLENLSEDSGAQL--AETLANLIKFSANVKDIRNLINNLP-------- ----SGLQN-----------------------LADCPEEQEKWKKSVATA ALKCLITSYxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------- -------------------------------------------IT----- -------------ASEWNSFVKNGLKYRYRD------------------- ---------------------HHFLSTLISLLEVMYRDGEVQKDRLPLST LHMMTISHSLFLPTMLASDEE-------xxxxx------xxS-------- -------------------xxx----------------------EELISL LFCLVKKCPSVCNINHFVVLLGAYGATLCTSDQKLLLLLQEYEKNQVSLL KF--Q---------------------------SFLWGPAALEHHKTRKSL GASLWKQASSDDLLALLKTDKMLQTVAHFPQQRRIIPQ------------ ---------------------DGMELLYSNNA------------------ -------------------------------V------------KDLGDL YDPCYLLP----LFSAILQP-----------------------ECVIDCL KFVSSHALGVTTMALSSYDPKVRAAAYHVLSCFYQHLEGARFREKRQLLY LMDIVKN------------------------------------------- ---------------------GIRQQNQRLPFVLTTYITKAAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYGFDL----------------- -----------EHKMEREWILTVLEEGISDGYCYQLCNQQGIFQILLGFS SSPLCDERFQ---------IIRVLCQAVRVTKAAYNLIKSSGLLSWIIQV VEK-RNL----EQQLLCAIIDLFHVLWFTNLGQK-------------E-K Q--ADEAK-ACSSTEEKPQSL--------------------------VKC LPLPFISEFLCVASTISRHL-Rxxx----ATQLKLFLQTLCSVLKH---- ---------RETALNVNKQADRLTLRPQSLSCTETVSLLLCWASL----- ------------SRNTALLTQIQALSEKHKMKEL-----M---------- -------------------------------------------------- ---------------xxxxxxxxxxx-----------------------x xxxx-------------xx------------------------------- -----xxx-----------------xxx---------------------- -------------------------------------------------I FVHWEPVLH----------------------------------------- -------------------------------------------------L TEPQPAQPKHKLDPSRLASDTVHLLTKW--------------------SL KWLVE--DSYDENRAKEFLHWLEKAVLQHKETVDVVLLDRGLKADLLRFY HQAFEARHHSSISS--------------------------RAETFQRFTN IMM------------------CLLETQR-HLPE--L-------------- -----------------HQAxxxxxxxxxxxxxx-----xxx-------- -------------------------------------------------- ------------LSLLSLYTHELWSGATSAELFLSHVSLV---------- ----NKAKC-KK---------------------------QKASKS-SxTP TAI----------------------RAIC-----------NDIITMK--- --------S----- >ENSLCRP00005000424 -------------------------------------------------- -----MS-------------------KKRLGGDS-EESKTPAKKEKV--- ------------------SEFNGTAFKAMLKEPSTAMK------------ -------------------G------------------------------ -----------------------------------------------LER FISTAKKLPCSDLYDVVEGYIKISMECAEIFKLLESDKHVETEMLLIFET LEMILLRTASDLSHFSMVGNAIVKKTVSSCMKLLQGSFYSENHRFVRQCL SLLSALVSQGPEAAREVLGQIRINKALSGLAKRKDKKGKPDVRMAFIQFV LSFLVSGDNTTVGQILEIKEFLPEILSTGLKEDRMSIVNLILSTLKTRVV LNKAISKTQKVRFFTPAVLANIASLYRWNGIVDATTDDNR--MGEDSDHA GISVIRELVHSFLLDLCSSRKHGISFHDASFGTAGRAGNIVLLQFLVGLK QATEDEMVAELVVNVLKVSPDLLARYFQETQYSYTPRIKSAWQDNVKLLK KIYESQPDVSTVFQTCEVIPLPRLHSMIMVISLPPVCNKAFFTQGLSLA- --------------------------------------NTAVQLTTLSMI NFILKRANKNIEYLLDKSECHNSDVYTPDVMGELVQQYRETLSKILPDMT SIVAKWQS-----------------------------LSKKE-------- -------------------------KTNGEEKVTKPEGSAxxxxxxx--- -------------------------------------------------- -----------------------xMPV-------AETAEVILLKALILQV ICLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMREEVPPVLQYQ ILQLALDLPASKFSWFRL-------------------------------- ---------QDVADT----E-SSSGEKSVLYLLLKMFVxSSS-SSHLKTS TKMLVLKVLKDSGVFEYTWTELELWLDQLDRVEPDQQETVIQFLERVMVK LVCNSYTYTDKVASLVQEAAYLQANLSSQEGDTASNPVSHI--------- ---------D---------------------------------------- --DVVDMLDVIMEGNEGEMEEFGPSLSEDLIVQTFPFSVVVPAALEARNK L-----------P----ADK-------G--------VVFEYLSAVLSDVL HCQREPLPLCLALLQYDKELAS-SEPSASSHP---SIIHLHQYYSKWLPQ QCREEL-------------------------------------------- -----------FKS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------PESHSKASSTPTSFT-------------ALMKAA YSQGPSA----------------FLEDAFRKSVGETLASMSMADFPVAIK QILLYIKSTVENLG---------TFSKDIGTAPLK---------TLMEIL QDLVTRLQGYQDTTN--------PEP------------------------ -----------------------AAxNSQ--------------------- -----------------------EGSEL-----------FLEINQSPTVE -------------ANKEQILLSALGSIFKHPCLEQWFLALELAALPPHTL NPVRLKNTCAQLNDDILALLKTSTPTLCDLGHLELICTYMGSIEKAVLKE L--------MEK----GSRPAKKQSRPFQALLSLHRYMDSCNLREVVSKL LLLPQESLIS----------T-SSKSTRAELSVYGHAAVQILTEAKANPS QDHG--IFLSQ--------------------------------------- ---AHLHGLGTLLLSCSSPALEAFLLQTLSSEPSSAKLIHTDVLLHCL-- ------Q----WPLPDTQAISGLLLQNCSTHRLCFEVWCLE--------P ANMEKLSDQTETF---LPLINTYLQVASREDPARPKD------------- -------------------------------------------------- --------------------VQKEVLKALKQGLLVK-------------- ------------------------------------------------LS QSVLGNLTEDSGAQL--VETLARLIKLSANVKDTRDLINNLP-------- ----NALQKVDSF-E------RWKLIDVITEKLSDCPEEQETWKKSVTTA ALKCLITAY-------------------------------SHSKEQ---- --------------SAPLSEQEKNVLDRL-QQLLT----SPKDIS----- -------------ASEWNGFVKNGLKYRYRD------------------- ---------------------HHFLNTLSNLLELVYDSGNVQKDLIPLST LHMMTSSHSLFLPTMLESHEEP-SRCQAK--------------------- --------------------------------------------EALVSL LLCLVKKCPTVCNSNHFVVLLGAYGVTLSTTDQKLLLLLQEYERNNVSLL KF--Q---------------------------SFLWGPAAVDHHKTRKSL GASLWKQASSDDLLAMLKSDRMLQTIARFPQQRRII-------------- -------------------xxDGKEQLYSNNA------------------ -------------------------------V------------KDLGNL YDPCFLLP----LFSTILGP-----------------------ECVIDCL KFVSSHALGLTVMALSSYDPKVRAAAYHVLSCFYQHLEGARIKEKRQLLY LMDTVKN------------------------------------------- ---------------------GIRQQNQRLPFVLTTYITKVAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYGFDL----------------- -----------EHKMEREWILSVLEEGISDGHCYELCDQQGIFQTLLGYS SSPLCDEHCQ-------AQIIKVLCQAARVTRAAYNLTKSCGLLTWMIQM VEK-KNL----DQQLLSAIIDLLHVLWFTNLGQK-------------E-K Q--LDEAxxSSSSAEEKPQSS--------------------------VKC LPLPLISEFLYVATTISRHL-R---LRVKAAQLSLFLQTLCSILKH---- ---------CGAALDINKQADRLTLHPQPLSCTEVLTLLLCWASL----- ------------SRNTAVLTQIQALSEKHKVKEL-----LG--------- ----------------------------TGKDKTRGK------------- ------GS-----xxx---------------------------------- -------------------------------------------------- ---------------------------xxTRKENLADDAE---------- ----------------------TEKQEESL---------LTECKSYLSSI FVHWEPVFP----------------------------------------- -------------------------------------------------L SEPQPAQPRDKLHPGRLASDTAHLLTKW--------------------SL RCLVE--DSYDENRTKEFLHWVEKAVIKHREIVDVVLPDAGLKADLLRLH HQAFEAQCHSCISE--------------------------REETFQLFNN IMI------------------HFLESQG-QLPE--L-------------- -----------------HQA----------------------VVSA---- ----------CLPEATC-DQSRR-E--------AG--------------- ------------LFLSSLYIHELWSGATSAELFMSHVSLV---------- ----TRAKC-KR---------------------------QKSSKS-SxTQ TAI----------------------RAIC-----------SDILPMK--- --------S----- >ENSSMAP00000006149 -------------------------------------------------- -----MG-------------------KKRLSEDS-AESNTPAKKEKV--- ------------------PEFNGTVFKTMLREPTTAKK------------ -------------------G------------------------------ -----------------------------------------------LET FISTARKLPCSDLYDVVEGYIKISMECAEIFKLLEGEKHVESELMLAFES LEMILLRTASDLSHFNMVGSAIVKKTVSGHMRLVQGSLHSQNHRFVRQCL GLLSALVSQGPEAAREVLSHIHINKALSGLAKRRDKKGRPDVRMAYIQFV LSFLVSGDSATVGQIVELKELLPEILSTGLKEDRMSLVNLILSTLKTRVL LNKALSKTQKVRFFTPAVLANIASLYKWNGIVDATTDDNR--MVENSEQA GISVVRELAHSFLLDLCCSRKHGIIFHDASFGTAGRAGNIVLLQFLVGLK QATEDELVAELVVNILKACPDILARYFKETQYSYTPRLKSAWQDNVRLLK KIYQAQPEVSTVFQTGEVIPLPRLLSMMMVISLPPVCNKAFFTQGLSFA- --------------------------------------NTAVQLTTLSMM NFILKRANKNIEYLLDESEWHSSDVYSPDLMGDLVQQYRETLSKILPDMT SIVAKWQS-----------------------------LSKKE-------- -------------------------KMDCEGNKTKEAGSAxxxxxxx--- -------------------------------------------------- -----------------------xVPx------xSETAEVILLKALILKV VCLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGLREEVPPVLQYQ ILQLALDLPASKFSWFRI-------------------------------- ---------QDAADT----E-SSSGEKSVLYLLLQMFV-xxx-x-HMRNS TQMLVLKVLKDSGVFEYNWTELELWLDQLARVEPDQQEIVIHFLERVLVK LVCSSYTYTDKVASLVQEAAYLQANLGSQEGDAVSIPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGNDGEMEEFGPSLSEDLIIQTFPFSVVVPAALEARNK L-----------P----ANQ-------G--------VVYEYLSAVLADVL HCQREPLPLCLALLQYDKELAS-SNPSASPHP---AIKHLHQYYSNWLPQ QHKEEL-------------------------------------------- -----------FKS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SECLSNGLPTANSYT-------------SLMKAA YSQGPSA----------------LLEDTFRKNVEETLTLMSVEEFPVAIK QILLYIKSTVENFG---------TFSKDMGAGLLK---------TLMGQL QDLVTKLQGFQGTKK--------SEPxx---------------------- -------------------TxAxAAxNFQ--------------------- -----------------------DGSDL-----------FLELNQSHAVE -------------ASEEQILVSALGSIFKHPCLDQWFLALESSALPPHTL NPVRLKHLCAQLTEDTLALLETSAPILRDLSHLELLCGYMGTIERVVVKE L--------MEN----SSQAAKTQSRPVQALLSLHSYMDPGNLREVVSKL LLLPRESLIS----------S-GSKGTRAKLSVYGNAALQILTECKSNPS QDHS--TFLTQ--------------------------------------- ---AHLHGLSTLLLSCSSPALEAFLYQALSGEPGSAKLIHTDVLLHCL-- ------Q----QPx----ALSSLLLQNSSTHRLCFELWCLE--------P ANMEKLSNQTETF---LPLINTYLQVAGREDPARPKD------------- -------------------------------------------------- --------------------VQKAVLKSLKTALLAK-------------- ------------------------------------------------MS QCVLGSLTDVCGAQP--AETLACLIKLSANIKDVRDLIENLP-------- ----SALQKVDSF-E------RWQLVEVLTEKLADCPEDLENWRRSITAA ALKCLITSY-------------------------------SHCKDQ---- --------------AASPSEQEQSILERL-QRLLT----SAEDIL----- -------------ASEWNSFVKNGLKYRYRD------------------- ---------------------HHFLNTLSSLLDLMYGGSEVQKDLIPLST LHMMTSSHSLFLPTMLDPDEEP-SRCQAK--------------------- --------------------------------------------EALVSL LLCLVKKCPAVCNTSHFVVLLGAYGATLNVSDQKLLLLLQEYERNHVSLL KF--Q---------------------------SFLWGPAAVEHHKTRTSL GASLWKQASSDDLLALLNTERMLQTIANFPQQRRIIPQ------------ ---------------------EGKEMLYSNKT------------------ -------------------------------V------------TDLGNL YDPCFFLP----LFSAILQP-----------------------ECVIDCP KFVSSHALGLTVMALSSYDPKVRAAAYHVLSCFYQHLEGARFREKRQLLY LMDTVKN------------------------------------------- ---------------------GIQQHNQRLSFVMTTYISKVAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYGFDM----------------- -----------EHKMEREWILSVLEEGIGDGHCYELCERQGIFQSLLGFS SSPLCDEHAQ-------AQIIRVLCQAARVTKAAYNLTKNCGVLTWMIQV VEK-RNR----DLHLLSAIIDLLHALWFTNLGQK-------------E-M Q--VDEAx-xxSSTEEKPQST--------------------------VKV LPFPLISEFLCVTLTISRHL-R---LGVKAAQLVLFLQTLCSILKH---- ---------RGTALSVKKDAERFALLPQPLSCAEALILLLCWASL----- ------------SGNKPLCTQIQILSEKHKVKEL-----LG--------- ----------------------------MGKDKGRSK------------- ------GSxxxxx------------------------------------- -------------------------------------------------- -----------------------------TQKDNLAKEAE---------- ----------------------FESQGESL---------LAESEFHLSSI LLHWEPVLL----------------------------------------- -------------------------------------------------L SEPQKVQPRDKLDPSQLANDTAHLLTKW--------------------SL RCLVE--GSYDENRTKDFLHWLEKAVIKHKEIIDVVLLDPALKSDLLRLY HQTFEAQSVSSLSA--------------------------RVETFQRFTS IMV------------------CLLETHG-QLPE--M-------------- -----------------HHA----------------------VVSA---- ----------CQPKDTN-DPSRC-D--------AG--------------- ------------LHLLLLYIHEQWSGATSAELFLSHVSLV---------- ----TGAKCxKK---------------------------xxTSKx-x--Q TAL----------------------RAMC-----------NDIITWK--- --------S----- >ENSSLDP00000030058 x------------------------------------------------- ----KMG-------------------KKRRGDGS-AESDTPAKKEKV--- ------------------AEFNGTVFKAMLKEPTTAIK------------ -------------------G------------------------------ -----------------------------------------------LET FISTAKKLPCSDLYDVVEGYIKISMECAEIFKLLEGEKHIESEMMLIFES LEMILLRTASDLTHFNMVGNAIVKKIVSSYMKLLQGSFHSENHRFVRQCL SLLSALVSQGPEAAREVLSHIHINKALSGLAKRKDKKGKPDVRMAFIQFV LSFLVSGDNATVGQILESKELLPEILSTGLKEDRMSVVNLILSTLKTRVL LNKGISKTQKVRFFTPVVLANIASLYKWNGIVDATTDDNR--MSENSEHA GISVIRELVHSFLLDLCSSRKHGISFHDASLGTAGRSGNIVLLQFLVGLK QATEDELVAELVVNVLKASPDILARYFKETQYSYTPRLKSAWQDNVRLLK KIYQAQPELSAVFQTSEVVLLPRLLSMIMVISLPPVCNKAFFTQGLSLA- --------------------------------------NTAVQLTTLSMM NFILKRAHKNIEYLLDKSEWNSSDVYTLDVMGDLVQQYRETLSKILPDMT SIVAKWQS-----------------------------LSKKE-------- -------------------------KTSAEEKKAKPEGSGxxxxxxx--- -------------------------------------------------- -----------------------xVPD-------AETAEVIMLKALILQV ICLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMREEVPPVLQYQ ILQLALDLPASKFSWFRI-------------------------------- ---------QDVADT----E-SSSGEKSVLYLLLKMFV-SSS-SSHLKTS TRMLVLKVLKDSGVFEYTWTELELWLDQLARVESNQQEAVIQFLERVLVK LVCNSYTYTDKVASLVQEAAYLQANLSSQEGDAASIPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMDGNDGEMEKFGPALSEDLIIQTFPFSVVVPAALEARNK L-----------P----ANK-------G--------VVYEYLSAVLSDVL HCQREPLPLCLALLQYDKELVS-SELAAAPHP---AVARLHQYYSRWLPQ QCGGEL-------------------------------------------- -----------FKS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SECLSKGLPTLSSYT-------------ALMKAA YSQGPST----------------LLEETFTKNVEETLAFIAMAEFPVAIK QILLYIKSTVEIFG---------TFSKDTGAAILK---------TLMGQL RDLVTKLLGFQETKK--------PEP------------------------ -----------------------IAxNLQ--------------------- -----------------------EGSDF-----------FLELNQSSTVE -------------ADKEQILVSALGSIFKHPCLEQWFLALELSALPPHTL NPVRLKHLCAQLTDDILALLKISAPILRDLSRLELLCSYMGALERAALKE L--------TEK----GSQAAKTQSRPFHALLSLHSYMDPSNLREVVSKL LLLPQESLIS----------P-GSEGTHANLSVYGHAALQILTECKSNPS QDHS--SFLTQ--------------------------------------- ---AHFHGLGTLLLSCSSPALEAFLLQTLSSEPSSAKLIHTDVLLHCL-- ------Q----QPLSDTQAISSLLLQNSSTHRLCFEVWCLE--------P ANMEKLSGQTETF---LPLINTYLQVAGREDPARPEE------------- -------------------------------------------------- --------------------VQKEVLKVLKQALLTK-------------- ------------------------------------------------LC QCVLGNLTEASGGQF--AETLANLIKLSANIKDIRDLINNLP-------- ----SALQKVDSL-E------RWQLVDVVTEKLADCPEELETWRKSVTSA ALKCLITSY-------------------------------SHSKDQ---- --------------ATSPAEQEQSVLERL-QTLLT----SAADIT----- -------------ASEWNSFVKNGLKYRYRD------------------- ---------------------HHFLNTLSSLLNLLYGGGEVQKDLIPLST LHMMTSSHSLFLPTMLESDEEP-SRYQAK--------------------- --------------------------------------------EALVSL LLCLVKKCPAVCNISHFVILLGAYGATLNTSDQNLLLLLQEYERNHVSLL KF--Q---------------------------SFLWGPAAVEHHKTRKSL GASLWKQTSSDDLLALLKSDRMLQTIAHFPQQRRII-------------- -------------------xxEGKEPLYSNNR------------------ -------------------------------V------------KDLGNL YDPCFLLP----LFSTILQP-----------------------ECVIDCL KFVSSHALGLTVMALSSYDPKVRAAAYHVLSCFYQHLEGARLREKRQLLY LMDTVKN------------------------------------------- ---------------------GVRQQNQRLPFVLTTYITKAAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYGFDL----------------- -----------EHKMEREWILGVLEEGISDGHCYELCDQQGIFQSLLGFS SSPLCDEHAQ-------AQIIRVLYQAARVTKAAYNLTKNCGVLTWMIQM VEK-RNR----DQQLLSAIIDLLHMLWFTNLGQK-------------E-K Q--VDGAx-xxSSKEEKPQSS--------------------------VKY LPLPLISDFLCVALTISRHL-R---LGVKAAQLSQFLQTLCSILKH---- ---------RGTALNVNKQAEWLTLLPQPLSCTEALALLLCWASL----- ------------SCNTALCSQIQVLAEKCKVKEL-----LG--------- ----------------------------MGKDKARTK------------- ------GSxxxxx------------------------------------- -------------------------------------------------- -----------------------------TEKEKLADDTE---------- ----------------------TEKQGESP---------LTACKHYLSSI FVHCEPVFP----------------------------------------- -------------------------------------------------L SETQQVQPRDKLDPSRLASDTAHLLTKW--------------------SL RCLVE--DSYDENRTKDFLQWFEKAVIKHREIVDVVLLDPGFKADLLRLY HQAFEAQRQSNILA--------------------------RVETFQRFTN IMI------------------RLLETQG-HLPE--L-------------- -----------------HQA----------------------VVSA---- ----------CLPEATR-DQSRY-D--------AG--------------- ------------LHLLSLYIHELWSGATSAELFLSHVSLV---------- ----TRAKS-KR---------------------------QKTSKS-x--Q TAI----------------------RAIC-----------NDIISLK--- --------S----- >ENSSDUP00000016873 x------------------------------------------------- ----KMG-------------------KKRRGEDS-AESDTPAKKEKV--- ------------------AEFNGTVFKAMLKEPTTAIK------------ -------------------G------------------------------ -----------------------------------------------LET FISTAKKLPCSDLYDVVEGYIKISMECAEIFKLLEGEKHIESEMMLIFES LEMILLRTASDLTHFNMVGNAIVKKIVSSYMKLLQGSFHSENHRFVRQCL SLLSALVSQGPEAAREVLSHIHINKALSGLAKRKDKKGKPDVRMAFIQFV LSFLVSGDNATVGQILEIKELLPEILSTGLKEDRMSVVNLILSTLKTRVL LNKGISKTQKVRFFTPAVLANIASLYKWNGIVDATTDDNR--MSENSEHA GISVIRELVHSFLLDLCSSRKHGISFHDASLGTAGRSGNIVLLQFLVGLK QATEDELVAELVVNVLKASPDILARYFKETQYSYTPRLKSAWQDNVRLLK KIYQAQPELSAVFQTSEVVPLPRLLSMIMVISLPPVCNKAFFTQGLSLA- --------------------------------------NTAVQLTTLSMM NFILKRAHKNIEYLLDKSEWNSSDVYTLDVMGDLVQQYRETLSKILPDMT SIVAKWQS-----------------------------LSKKE-------- -------------------------KTSGEEKKAKTEGSGxxxxxxx--- -------------------------------------------------- -----------------------xVPD-------AETAEVIMLKALILQV ICLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMREEVPPVLQYQ ILQLALDLPASKFSWFRI-------------------------------- ---------QDVADT----E-SSSGEKSVLYLLLKMFV-SSS-SSHLKTS TRMLVLKVLKDSGVFEYTWTELELWLDQLARVEPNQQEAVIQFLERVLVK LVCNSYTYTDKVASLVQEAAYLQANLSSQEGDAASIPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMDGNDGEMEKFGPALSEDLIIQTFPFSVVVPAALEARNK L-----------P----ANK-------G--------VVYEYLSAVLSDVL HCQREPLPLCLALLQYDKELVS-SELAASPHP---AVTRLHQYYSRWLPQ QCREEL-------------------------------------------- -----------FKS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SECLSKGLPTPSSYT-------------ALMKAA YSQGPSA----------------LLEDTFTKNVEETLAFISMAEFPVAIK QILLYIKSTVEIFG---------TFSKDTGAAILK---------TLMGQL RDLVTKLLGFQETKK--------PEP------------------------ -----------------------IAxDLQ--------------------- -----------------------EGSDL-----------FLELNQSSTVE -------------ADKEQILVSALGSIFKHPCLEQWFLALELSALPPHTL NPVRLKHLCAQLTDDILALLKISAPILGDLSRLELLCSYMGALEKAALKE L--------MEK----GSQAAKTQSRPFHALLSLHSYMDPCNLREVVSKL LLLPQESLIS----------P-GSEGTQANLSVYGHAALQILTECKSNPS QDHS--SFLTQ--------------------------------------- ---AHFHGLGTLLLSCSSPALEAFLLQTLSSEPSSAKLIHTDVLLHCL-- ------Q----QPLSDTQAISSLLLQNSSTHRLCFEVWCLE--------P ANMEKLSGQTETF---LPLINTYLQVASREDPARPKE------------- -------------------------------------------------- --------------------VQKEVLKVLKQALLTK-------------- ------------------------------------------------LC QCVLGNLTEASGGQF--AETLANLIKLSANIKDIRDLINNLP-------- ----SALQKVDSL-E------RWQLVDVVTEKLADCPEELETWRKSVTSA ALKCLITSY-------------------------------SHSKDQ---- --------------ATSPAEQEQSVLERL-QTLLT----SAADIT----- -------------ASEWNSFVKNGLKYRYRD------------------- ---------------------HHFLNTLSSLLNLLYGGGEVQKDLIPLST LHMMTSSHSLFLPTMLESDEEP-SRYQAK--------------------- --------------------------------------------EALVSL LLCLVKKCPTVCNISHFVILLGAYGATLNTSDQNLLLLLQEYERNHVSLL KF--Q---------------------------SFLWGPAAVEHHKTRKSL GASLWKQTSSDDLLALLKSDRMLHTIAHFPQQRRII-------------- -------------------xxEGKEPLYSNNR------------------ -------------------------------V------------KDLGNL YDPCFLLP----LFSTILQP-----------------------ECVIDCL KFVSSHAFGLTVMALSSYDPKVRAAAYHVLSCFYQHLEGARLREKRQLLY LMDTVKN------------------------------------------- ---------------------GVRQQNQRLPFVLTTYITKAAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYGFDL----------------- -----------EHKMEREWILGVLEEGISDGHCYELCDQQGIFQSLLGFS SSPLCDEHAQ-------AQIIRVLCQAARVTKAAYNLTKNCGLLTWMIQM VEK-RNR----DQQLLSAIIDLLHMLWFTNLGQK-------------E-K Q--VDGAx-xxSSKEEKPQSS--------------------------VKY LPLPLISDFLCVALTISRHL-R---LGVKAAQLSPFLQTLCSILKH---- ---------RGTALNVNKQAEWLTLLPQPLSCTEALALLLCWASL----- ------------SCNTALCSQIQVLAEKCKVKEL-----LG--------- ----------------------------MGKDKARTK------------- ------GSxxxxx------------------------------------- -------------------------------------------------- -----------------------------TEKENLADDTE---------- ----------------------TEKQGESP---------LTACKHYLSSI FVHCEPVFP----------------------------------------- -------------------------------------------------L SETQQVQPRDKLDPSRLASDTAHLLTKW--------------------SL RCLVE--DSYDENRTKDFLQWFEKAVIKHREIVDVVLLDPGFKADLLRLY HQAFEAQCQSNVLA--------------------------RVETFQRFTN IMI------------------RLLENQG-HLPE--L-------------- -----------------HQA----------------------VVSA---- ----------CLPEATR-DQSRY-D--------AG--------------- ------------LHLLSLYIHELWSGATSAELFLSHVSLV---------- ----TRAKS-KR---------------------------QKASKS-x--Q TAI----------------------RAIC-----------NDIISLK--- --------S----- >ENSLCAP00010031556 -------------------------------------------------- -----MG-------------------KKRRSEDS-DESNTPAKKEKV--- ------------------PEFNGTVFKAMLKEPTTAMK------------ -------------------G------------------------------ -----------------------------------------------LET FISTAKKLPCSDLYDVVEGYIKISMECAEIFKLLEGEKHTDREVMLIFES LEMILLRTASDLPHFNMVGNAIVKKIVSSHMKLLQGSLHSEYHRFVRQCL SLLSALVSQGPEAAREILSHIYINKTLSGLAKRKDKKGRPDVRMAFIKFV LSFLVSGDNATVGQILEIKELLPEILSTGLREDRMSIVNLILSTLKSRVL LNKGISKTQKVRFFTPAVLANIASLYKWNGIVDVV---------xNSGHA GISVIRELAHSFLLDVCCSRKHGISFHDASFGTAGRAGNI---------- QATEDELVAELVVNVLKASPDVLARYFKETQYSYTPRPKSAWQDNVKLLK KIYEAQPELSAVFQTGEVIPLPRLLSMIMVISLPPVCNKAFFTQGLSVS- --------------------------------------D-SVQLTTLSTM NFILKKANKNIEYLLDKAESHSSDVHTLDMREDLVQQYRETLSKILPDIA SIVSKWQS-----------------------------LSKKE-------- -------------------------KTDGEEKKTETEGSAxxxxxx---- -------------------------------------------------- -------------------------------------TEVILLKALILQV ICLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMREEVPPVLQYQ ILQLALDLPASKFSWFRI-------------------------------- ---------QDVTDT----E-SSSGEKSVLYLLLKMFV-SSS-NGHLKTS TRMLVLKVLKDSGVFEYTWNELELWLDQLARAEPNYQDTVIQFLERVLVK LVCSSHTYTDKVASLVQEAAYLQANLSSQESDAASIPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGNDGVMEEFGPSLSEDLILQTFPFSAVVPAALEARNK L-----------P----ANK-------G--------VVFEYVSSVLSDVL HCQREPLPLCLALLQYDKELAS-SELSASPHP---AVIHLHQYYSKWLPQ QCREEL-------------------------------------------- -----------FNS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SECRSKGLSNPSSYT-------------ALMKAA YSEGPSA----------------LLKDTFRKNVEETLPLMSMAEFPVAIK QILLYIKSTVENFG---------AFSKDTGAALLK---------TFMGQL QDLVTKLQGFQETKK--------AEP------------------------ -----------------------AAxNFQ--------------------- -----------------------EGSDL-----------FLELNQLSTVE -------------ADKEQILISALGSIFKHPCLEQWFLALELSALPPHTL NPVRLKGLCSQLTDDILALLKASAPILHDLGHLEILCSYMGAIERAALKE L--------MEK----GSLAAKTQSRPFQALLSLHSYMDSCNVREVVSKL LLLPRESLIS----------P-SSEGTHAELSVYGHATLQILTECKSNSS QDHS--TFLTQ--------------------------------------- ---AHLHGLGMLLLSCSSPALEAFLLQALSSEPGSAKLIHTDVLLHCL-- ------Q----RPGSDTRAICSLLLQNSSTHRLCFEVWCLE--------P ANMERLSEQTETF---LPLINTYLQVASREDPARPKD------------- -------------------------------------------------- --------------------VQKEVLKSLKQALLAK-------------- ------------------------------------------------LS QCVLGNLTEDPGAQL--AETLANLIKLSANIKDIRDLINNLP-------- ----KALQKVDSF-E------RWQLVEVITENLADCPEEQETWRKSVTVA AFKCLIASY-------------------------------SHSKDQ---- --------------ATPPSEQEQNILERL-QRLLV----x--DIT----- -------------AAEWNSFVKNGLKYRYRD------------------- ---------------------HHFLNTLSSLLTVMYGGSEVQKDLIPLST LHMMTSSHSLFLPTMLDSDEDP-xx------------------------- ---------------------------------------------SLVSL LLCLVKKCPTVCDINHFVVLLGAYGATLNTSDQKLLLLLREYERNHVSLV KF--Q---------------------------SFLWGPAAVEHHKTRKSL GASLWQQATSDDLLALLKTDRMLQTIAHFPQQRKIIPQxxx--------x xxxxxxxx---------xx------------------------------- -------------------------------------------------L YDPCFLLP----LFSTILQP-----------------------ECVIDCL KFVSSHALGVTVMALSSYDPKVRAAAYHVLSCFYQHLEGARLREKRQLLY LMDTVKN------------------------------------------- ---------------------GIRQQNQRLPFILTTYITKVAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYGFDL----------------- -----------EHKMEREWILSVLEEGISDGHCYELCDQQSIFQSLLGFS SSPLCDEHSQ-------AQIIRVLCQAARVTKAAYNLTKSSGVLTWIIQV VEK-R-Y----DQQLLSAIIDLLHVLWFTNLGQK-------------E-K Q--ADGVK-TSSPTEEKPQRS--------------------------VKC LPLPLISDFLCVASSISRQL-R---LGLKAAQLSLFLQTLSSILKH---- ---------RRTALNVNKQAERLTLHPQPLSCTEALALLLCWASL----- ------------SGDMALFAQIQALSEKHKVKEL-----LG--------- ----------------------------MGKDKARSK------------- ------ASxxxxx------------------------------------- -------------------------------------------------- -----------------------------TKKENLAEDAE---------- ----------------------PEKQGESP---------LTACKLYLSSI FVHWEPVFP----------------------------------------- -------------------------------------------------L SKPKQVQPKDKLDSSHLATDTAHLLTKW--------------------SL RCMVE--DSYDENRTKDFVHWVEKAVIIHRDIVDVVLLDSGLKADLLRLY HQAFEAQCHSSFLA--------------------------RVETLQRFTN IMM------------------RLLEAQD-QLPE--L-------------- -----------------HHT----------------------VVSA---- ----------CLPEATH-DQSKY-E--------AG--------------- ------------LYLLSLYIHELWSGATSPELFLSHVRLV---------- ----TRVKC-KR---------------------------QKASKS-x--Q TAI----------------------RAIC-----------NN-xTLK--- --------x----- >ENSATEP00000016940 -------------------------------------------------- -----MG-------------------KKRRSEDS-AESSAAVK--xV--- ------------------PEFNGTVFKAMLKEPTTAMK------------ -------------------GEF---------------------------- ---------TITLCVVINASNLSLILGDVFISISTIHARFDALSPAxLEK FISTAKKLPCSDLYDVVEGYIKISMECAEIFKLLEGEKHTETEMMLIFES LEMILLRTASDLSHFNMVGNAIVKKTVSSYMKLLQGSFHSENHRLVRHCL SLMSALVSQSSEAAREILSNIHINKALAGLAKRKDKKGRPDVRMAFIQFV LSFMVSGDNTTVGQILEIKELLPEILNTGLKEDRMSIVSLILSTLKTRVV LNKAISKTQKVRFFTPAVLANIASLYKWNGIVDATTDDNR-----SSEHA GISVVRELVHSFLLDLCCSRKHGINFHDASFGTVGRAGNIVLLQFLVGLK QATEDELVAELVVNVLKASPDILARYFKETQYSYTPRPKSAWQDNVKLLK KIYEAQPELPTVFQAQEVIPVPRQLSMIIATSLPPVCNKAFFTQGLSLA- --------------------------------------NTAVQLTTLSMM SFILKRASKNIEYLLDKSEWQSSDVCMPDMMGNLLQQYRETLSKILPDMT SIVAKWQS-----------------------------LSKKEx------- -------------xxxxxxxxxxxx-------------SAxxxxxxx--- -------------------------------------------------- -----------------------xEPA-------AETAEVILLKALILQV ICLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMREEVPPVLQYQ ILQLALDLPASKFSWFRI-------------------------------- ---------QDAADT----E-SPSGEKSVLYLLLKMFV-TSS-NSYLKNS TQMLVLKVLKDSGVFEYTWTELELWLNQLTRVKPNQQDTVIHFLERVFVK VMCSSYTYTDKVASLVQEAAYLQANLTNQEGDAASIPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGNDGEMEEFGPSLSEDLINQTFPFSVVVPAALEARNK L-----------P----ADK-------G--------VVYDYLSAVLSDVL HCQREPLPLCLALMQYDKELVS-SEHTATPHP---SIVHLHQYYSKWLPQ QCREEL-------------------------------------------- -----------FNA------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------FQCQSKELPSPVSFT-------------ALMKAA NIQGPST----------------LLEDTFTKKVQEVLASMSLTEFPVAIR QILLYIKSTVEDFG---------TFTSDIGINLLK---------TFMEIL RDLVTKLQDFPVTTT--------SEP------------------------ -----------------------SAxNLQ--------------------- -----------------------EGSDL-----------FLEPNQSSTVE -------------ANKEKILVSALGSIFKHPCLEQWFLALELAALPPQTL NPVRLKHLYAQLNDDTLDLLKICAPILRDLGHLELLCSYMGAVEKAVLME L--------KEK----SSQATKKQSRPFHALLSLHSYMDPCNLREVISKL LLLPQERLIS----------S-SREGAHAQLSVYGHAALQILTEYKSNSS QDDS--TFLTQ--------------------------------------- ---SHLHGLGTLLLSCSSPALDAFMLQTLSSEPGSAKLIHSDVLLHCL-- ------Q----RPLPDTQAISSLLLKNSSTHRLRFEVWCLE--------P ANMQKLSDQTETF---IPLINTYLQMASREDPARPQD------------- -------------------------------------------------- --------------------VQKEVLKALKQQLFAK-------------- ------------------------------------------------LS RCVLENLAEDTGAQL--VETLASLIKLSANIKDIRDFINSLP-------- ----KVLQKVDSF-E------RWKLVDVISEKLADCPEEQETWRKSVTAS ALKCLITSY-------------------------------SQSKDQ---- --------------ATSPSQQEQSILERL-QRLLT----SAEDVT----- -------------ASEWNSFVKNGLKYRYRD------------------- ---------------------HHFLNTLSCLVEVMYSSSDHQMDLIPLST LHMMSSSHSLFLPTMLDSDDEP-SKYEAK--------------------- --------------------------------------------EALVSL LLCLVKKCPTVCNINHFVVLLGAYGATLNTLDQKLLQLLQEYEKNHVSLV KF--Q---------------------------SFLWGPAAVEHHKTRKSL GASLWKQASSDDLLALLKTDRMLKTIAHFPQHHRIIPQ------------ ------xxxxxxxxxxxx-------------------------------- --------------------------------------------KDPGNV YDPRFLLP----LFSAILRP-----------------------ECVIDCL KFVSSHALGVTVMALSSYDPNVRAAAYHVLSCFYQHLEGARFREKRQLLY LMDTVKN------------------------------------------- ---------------------GIRQKNQRLPFVLTTYITKVAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYGFDL----------------- -----------EHKIEREWILNVLQEGISDRHCYDLCDQQGIFQSLLGFS SSPLCDEHAQ-------AQIITVLCQAARVNKAAYSLTKSCGVLTWIIQV VEK-RNQ----DQQLLSAIIDLLHVLWFTNLGQK-------------Exx x--MEGAK-ATASTNEKPQSS--------------------------PKC LPLPLISEFLCVASTLSKHF-R---LGVKAAQLSLFLQTLCSILKH---- ---------HRTALNVNKQADRFTLPPQPLSCTEVLALLLCWASL----- ------------SHDTALLSQIQALSEKHKVKDL-----LG--------- ----------------------------MGRDKARGK------------- ------SSxxxxx------------------------------------- -------------------------------------------------- -----------------------------KRKENLAEDTD---------- ----------------------TEKQDKSL---------LTECKFYLSSI FVHWEPVFP----------------------------------------- -------------------------------------------------L SEPQLAQPRDKLDPSRLACDTVHLLTKW--------------------SL RCLVE--VSYDENRTEEFLCWLEKTVIKHREIVD-VMLDPGMKADLLRLH HQAFEAQCHSGISA--------------------------RMETFQRFTN IMI------------------RMLEAEG-HLPE--L-------------- -----------------HQA----------------------VISA---- ----------CLPEGAH-DPCRC-E--------AG--------------- ------------LFLISLYIHELWSGSLSAELFMSHVSLV---------- ----TRAKC-KR---------------------------QKSSKSxx--Q TAI----------------------RDIC-----------NDIIAMK--- --------S----- >ENSCGOP00000046219 -------------------------------------------------- -----MG-------------------IKRHMEDS-AESNTPLKKE-V--- ------------------PEFNGTVFKAMLKEPTTAMK------------ -------------------G------------------------------ -----------------------------------------------LET FVSTAKKLPCSDLYDVVEGYIKISMECAEIFKLLEREKHVESEMMLVFES LEMILLRTASDLSHFSMVGNAIVKKTVSSHVKLLQGSFQSENHRFVRQCL SLLSALVSQGPEAARDVLSHIHVTKALSGLAKRKDKRGRPDVRMAFIQFV LSFLVSGDNATVGQLLEIKELLPEILSTGLKEDRMSIANLILSTLKTRVV LNKFISKTQKVRFFTPVVLANIASLYKWNGIVDATVDDDR-----DSEHA GISVIRELVHSFLLDLCCSRKHGISFHDASFGTAGRAGNIVLLQFLVGQK QATEDELVMELVVNVLKASPDMLARYFKETQYSYTPRLKSAWQDNVKLLK KIYAAQPEISTAFQTGEVIPLPRLLSMIMVISLPPVCNKTFFTQGISV-- ----------------------------------------TVQLTTLSMM NFTLKRANKNLEYLLDKSEWHSSNVYTSDMMGDLVQQYRETLSKILPDMT SIVSKWQS-----------------------------LSKKE-------- -------------------------KTDAEEKKTKTEGSAxxxxxxx--- -------------------------------------------------- --------------------------------------KVILLKTQILQV ICLYQKVVPHLVSQCKFDFSKLLKG---------------------DAFF FFISLSSHVSYLFKVLxxWVFNKAFPxFTFPGIVSEKGMREEVPPVLQYQ ILQLALDLPASKFSWFRI-------------------------------- ---------QDVADT----ExSSSGEKSVLYLLLKMFV-SSS-SSHLKTS TRLLVVKVLKDSGVFEYTWTELELWLDQLAKVDANQQETVIQFLERVLVK LVCNSYTYTDKVASLVQEAAYLQANLSSQEGDAASIPISHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGNEGEMEELGPSLSEDLIIQTFPFSVVVPAALEARNK L-----------P----ADK-------G--------VVYEYLSAVLSDVL HCQREPLPLCLALQQYDKELVS-AELSASPHP---SIIHLHQYYSKWLPQ QCREEL-------------------------------------------- -----------FKS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SECHLKGMSTPNSFT-------------ALMKAA YSQGPNT----------------LLEDAFRKSVEGTLASMLMADFPAAIK QILLYIKSTVENL--------------xIGTAPLK---------AVMGIL LDLVSKLQGFQETTI--------SEP------------------------ -----------------------AAxNSQ--------------------- -----------------------EGADL-----------FLEVHQSSTTE -------------ANKEQILVSALGSIFKHPCLQQWFLALELAALPPHTL NPVRLKHMCAQLNDDMLALLKTCSPTLCDLGHLELISSYMESIEKAVLKE L--------MEK----GSQAAKKQSRPFQALLSLHSYMDSCNLREVVSKL LLLPHESLIS----------P-SSKGTQAELSVYGQAALQILTESKANPS QDHG--IFLSQ--------------------------------------- ---AHLHGLSTLLLSCSSPALEAFLLQTLSSEPASAKLIHTDVLLHCL-- ------Q----CPLPDSLSISSLLLKNCSTHRLCFDMWCLE--------P ENMEKLSDQMETF---LPLINTYLQVASREDPARPID------------- -------------------------------------------------- --------------------VQKKVVKALNQMLLAK-------------- ------------------------------------------------LS QCVLGNLTEDSGAQL--AETLANLIKLSANIKDTRNLVSTLP-------- ----NALQKVDSF-E------RWRLVDVITEKLADCPEEQDTWRKSVTAA ALKCLTAAY-------------------------------SHYKDQ---- --------------ATARSEQEQSILERL-QGLLV-----xDDIT----- -------------ASEWNSFVKNGLKYRYRD------------------- ---------------------HHFLKTLGNLLELMYGGREVHKDLIPLST LYMMTSSHSLFLPTMLDSDEEA-SRCQAKx-------------------- ---------------------xxxxxxxxxxxxxxxxxxxxxxx------ -------------------------------DQKLLLLLQEYERNNVTLL KF--Q---------------------------SFLWGPAAVEHHKTRKSL GASLWKQESSDDLLALLKSDWMLQTIAHFPQQRRIM-------------- -------------------xxDDKELLYCNTA------------------ -------------------------------V------------KDLGNV YDPRFLLP----LFSTILQP-----------------------ECVIDCL KFVSSHALGVTLMSLSSYDPNLRAAAYHVLSCFYQHLEGARVREKRQLLY LMDTVKN------------------------------------------- ---------------------GIRQQNQRLPFVLTTYIAKVAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYGFDL----------------- -----------EHKMEREWILSVLEEGISDGHSYELCEQQGIFQTLLGFS SSPLCDEHSQ-------AQIIRVLCQAARVTRAAYNLTKSCGLLTWIIQV VEK-RNL----DQQLLSAIIELLHVLWFTNLGQK-------------E-K Q--VDGAK-TSSSTEEKPQSS--------------------------GKC LPLPLINEFLSVASTISRHL-R---SRVKAAQLNLFLQTLCSVLKH---- ---------RGTALNVNKQADWLTLHPQPLSCTESLTLLLCWASL----- ------------SHNTALLTQIQALSEKHKVKEL-----LG--------- ----------------------------MGKDKARGK------------- ------GSxxxxx------------------------------------- -------------------------------------------------- -----------------------------TRKENLAEDAE---------- ----------------------TEKQEESL---------LTQCTFYLSSI FVHWEPVFP----------------------------------------- -------------------------------------------------L SEPQPAQPRDKLDASQLAGDAAHLLTKW--------------------SL RCLVE--DSYDENRTKEFLHWVEKAVMKHSRIMNVVLLDPGMKADILRLY HQAFDAQCHSSISA--------------------------RVEVLQLFTN IMI------------------RLLETRG-NLPE--L-------------- -----------------HQA----------------------VVSA---- ----------CLPAATH-DQSTR-E---------G--------------- ------------LFLLSSYVHELWRGATSAELFLSHVSLV---------- ----TGAKC-NR---------------------------QKASKP-SxKQ TAI----------------------RAIC-----------NDIITLK--- --------S----- >ENSBSLP00000042280 xxPAGQHFRxxx------SCVYTATWxTVTDLVWLxxKTLKExLSLSCGC FSxxxMS-------------------KKRRSEDS-AESNIPEKKG----- ------------------TEFNGTVFKAMLKEPTMAMK------------ -------------------G------------------------------ -----------------------------------------------LGE FISTAKRLPSSELYDVVEGYIKISMDCAEIFKLLEGEKHIESEMLLIFES LEMILLRTASDLSHFNMVGNAIVKKIVSSYMKLLQGSFHSENHRFVRQCL NFLSALVSQGPEAAKEILGHIHISKALSALARRKDKRGRPDVRVAFIQFV LSFLVSGDITTVGQLLEIKELLPEILSTGLKEDNMSTVCLIVSTLKSRVV LNKGLRKTQKVRFFSPAVLANIASLYKWKGIVDATTEDDR--MVTNSEQA GRSVVRELVHSFFLDLCCSRKHGISFHDPSFGTVGRAGNIVLLQFLVGLK QATEDELVAELVVNVLKASPDVLARYFKETQYSYIPRAKDAWQDNIRLLK KIYEAQPELCTLFQSRDVVPLPRLLSMIMVISLPPVCNKAFFTQGLSLA- --------------------------------------NTAVQLTTLSMM NFILKRAKKNIEYLLDKSEGHRSDVYSPDMMEELVQQYRETLSKVLPDIM SIVSKWQS-----------------------------LSKKDxxxxxxxx xxxxxxxxxxxxxx------------------------------------ -------------------------------------------------- ----------------------------------ADTAEVVLLKAVILQV ICLYQTVAPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMREEVPPVLQYQ ILQLALDLPASKFSWFRI-------------------------------- ---------QDVADA----E-SSSGEKSVLYLLLKMFV-TSR-SSYLKNS TQMLVLKVLKDSGVFEYTWTELELWLNQLARLESNQHDTVIHFLERVFVK LVSSSYTYTDKVASLVQEAAYVQTNLGSQEGDAVSIPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGNDGEMEEFGPALSEDLINQTFPFSVLVPAALEARNR L-----------S----ADK-------G--------VVHGYLSAVLSDVL HCQREPLPLCLALMQYDKELVS-SAHPGSPHA---SVIHLHQYYSKWLPQ QCREEL-------------------------------------------- -----------FKD------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SECDSKDLPPPASFT-------------ALMKAA YSQGPSA----------------LLPDSFRKELKEALASMLMPEFPVAIK QILLYIKSTVENFG---------TFAKDIGTTLLK---------TYMEIL QDLVTLLQDFQETTV--------SEP------------------------ -----------------------PExNYQ--------------------- -----------------------EASDL-----------FLEPNQSPSVE -------------ANKEKILVSALGSIFRHPCLEQWFLALELATVPPQTL NPIRLKQLCAQLSDDILGLLETSAPTLRDLGHLEILGSYIGAIENAVLKE L--------TDK----ASQGAKKQSRPFKALLSLHSYMEPCTLRKVISKL LLLPHKRLIS----------S-GNEGAQAQLSVYGHAALQILTESKCSSS QDQS--TSLTQ--------------------------------------- ---AHLHGLGTLLLSCSSPALEAFLLQTLSTEPGNAKLIHPDIFLHCL-- ------Q----RPLPDSQAISSLLLQNSSTHRLCFEMWCLE--------P VNMESLSGQIEAY---IPLIHAYLQMADREDPARPQDxLY---------- -------------------------SQNNSVCCLITRSPTNVTLVVSPSP NLYFIxxxxxxxxxxxxxxx---------------K-------------- ------------------------------------------------LS QWVLENLSKDSGAQL--VETLASLIKLSASIKDIGDLISGLP-------- ----NALQKVDSF-E------RWKLVNVIFEKLADSPAEQETWRKSVTAS AIKCLITSY-------------------------------SQFKDP---- --------------QTSPSTQEQSILERL-QRHLI----SAEDIT----- -------------ASEWNSFVRNGLKYRYRD------------------- ---------------------HHFLNTLSSLLEPMYRSSDAQKDLILLST LHMMTSSHSLFLPTMLDSDEEH-SYYQAK--------------------- --------------------------------------------EALVSL LLSLVKKCPTVCNISHFVVLLGAYGATLNTLDQKLLLLLQEYERNHVSLL KF--Q---------------------------SFLWGPAAVEHHKTRKSL GSSLWKQASTDDVLALLKPDRMIETIKRFPQNHRILPQ------------ ---------------------DGNELIHNNIS------------------ -------------------------------G------------TDLENL YDPSFLLP----LFSAILQP-----------------------ECVIDCF KFVSSHALGVTVMALSSYDPNVRAAAYNVLSCFYQHLEGARFREKRQLIY LMDTVKN------------------------------------------- ---------------------GIRQQNQRLPFVLTTYLSKVAQQMLRPED HMYIVLNRFLLSQQSLDFRRVPEFFKLFCGFDL----------------- -----------EHKLEREWILGVLEEGISDGHCYDLCEQQGIFQKLMGYS CSPVCDEHCQ-------AQILRVLCQAAHVKRAAHSLTKSCGILTWMIQF VEK-RNL----DQQLLSSIIDLLHGLWFSNLGQR-------------Exx x--VEGAQ-TTSSTKEKHQTS--------------------------VKC LPLPLVGEYLCVASTISKYL-R---LGVKASRLSLFLQTLCSILRH---- ---------RGTALSVNKQAERITLPPQPLSCVEALALLICWASL----- ------------SHNTALVTQIHALSEKHKVKDL-----LG--------- ----------------------------MGKNKARGK------------- ------SSxxxxx------------------------------------- -------------------------------------------------- -----------------------------KRKDNLAEDVE---------- ----------------------AEKQEESL---------LTECKFYLCSI FVHWEPVFP----------------------------------------- -------------------------------------------------P SDPQSAQPRGKLDPSLLACDTVHLLTKW--------------------SL RCLVE--VSYDENRTKEFLCWLEKSVIKHREIINALLLDPGVKADLLRLH HQFIQSRYHCGISA--------------------------GMETFQRFNN IMI------------------CLLETEG-HLPE--L-------------- -----------------HQT----------------------VVSA---- ----------CLPEATH-EPCRN-E--------AG--------------- ------------LFLLSLYIHELWSGSSSAELFMSHVSLV---------- ----ARAKC-KR---------------------------QKALK--xxAQ TAV----------------------RAIC-----------DDIMGMK--- --------N----- >ENSPRNP00000025993 -------------------------------------------------- -----MG-------------------KKRSSDVP-PDSNTPAKKNKV--- ------------------PEFNGTVFKSMLKEPTTAMK------------ -------------------G------------------------------ -----------------------------------------------LET FISTAKKLPCSDLYDVVEGYLKISMECAEIFKLLEGERHIESEMMLIFES LEVILLRTASDLSHFSMVGNAIVKKTLSGYMKLLQGSFHSENHRFVRQCL SLLTALVSQGQEAAREVLSHIHINRGLSALAKRRDKKGRPDVRQAFVQFI LSFLVSGDNGTIGQILEIKELLPEILRMDLKEDRMSTVSLILSTLKSRVL LNKAISKTQKVRFFTPAVLASVASLYKWNGIVDATTDDNR--IQGNSELA AVCIIRELVHSFLLDLCCSRKHGLCFYDASLGTAGRGGNIVLLQFLVGLK QVTEDELVADLVVNILKASPDILSRYFKETRYSYTPRLKSAWQDNVKLLK KIYEAQPDISTVFQTQEVVPLPRLLSMIMVISLPPVCNKAFFTQGLNLS- --------------------------------------NKTVQLTTLSMM NFLLKRASKNVEYLLDKSACYNSDVYTVDMMGELMQQYRETLSKILPDMT SIIATWQS-----------------------------LSKKE-------- -------------------------RSDGEEKKTKTGG--------xxx- --------------xx----------------xx---------xxxx--- ----------------------xxLPG-------AETAEVILLKALILQV ICLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGLREEVPPVLQYQ ILQLALDLPASKFSWFRI-------------------------------- ---------QDSSDT----E-SPSGEKSVLYLLLKMFV-x---SSHLKTS TQMLVLKVLKDTGVFEHTWSELEFWLNQLARLEPTHQETVIQFLERVLVK LVCNSYTYMDKVAGLVQEAGYLQANLNNQEGEAASIPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGSDGEMEEFGPSLSEDLIIQTFPFSAVVPAALEARNK L-----------P----ADK-------G--------VVYEYLSAVLSDVL HCQRDPLPLCLALLQYDKELVS-SELSAPAHS---SVIHLHHYYSKWLPK QCHEEL-------------------------------------------- -----------FKP------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------FECHPDGGPTPSSCT-------------ALLKAA YIQGQSA----------------FLEESLKKDVDVALASMSVTEFPVAIK QILLYIKTTVENFG---------TFSKDSGTALLK---------TLMNIV HDMVTKLQGFHETKT--------FEP------------------------ -----------------------ATxETQ--------------------- -----------------------EGSDL-----------FLELNQSSSAE -------------ASKEQILVSALGSIFKHPCLEQWFLALELSALPPHSL NPVGLKRLCAQLTDDILALLKISAPILRGLNHLELLHSYMEAVERAVLKE L--------TEK----VSQPVKTHSRSFQALLSLHSYMHSCNVRGVVSKL LLLPHDGLIS----------P-SNEGTHSELSVYGHAALQILTECESTPx --HG--TFLTQ--------------------------------------- ---AHLHGLGTLLLSCSNPALETFLLQTLSAEPGSAKLIHTNVLLHCL-- ------Q----QPIADTLAISSLLLQNCSTHRLCFEVWCLE--------P TNMEKLSSETEAF---LPLINTYLQVASREDPARPSD------------- -------------------------------------------------- --------------------VQNEVLKSLKQALLVK-------------- ------------------------------------------------LS KSLLETLTADSGAQL--AETLASLIKLSANIKDIRDLINDLP-------- ----GALQNVDSL-Q------RWQLVDVITEKIADCTEEQDKWRKSVTSA AVKCLSATY-------------------------------SHFKDQ---- --------------ATSPSDQEQNILKRL-QHLPT----SAEDIA----- -------------ASEWNSFVKNGLKYRYRD------------------- ---------------------HHFLNILSSLLELMYGGSEVQKDLIPLST LHMMTCSHSLFLPIMLDSSEEQ-SMYQAK--------------------- --------------------------------------------EELVSL LLFLVKKCPTVCNVSHFGILLGAYGATLCSLDQKLLLLLQEYERNQVSLL KF--Q---------------------------SFFWGPAAVEHHKTRKSL GASLWKQASSDELLALLKADRMLQTVAHFPQQRKLI-------------- -------------------xxGADELLNNNVA------------------ -------------------------------L------------KNPGNV YDPCFLLP----LFSAILRP-----------------------ECVIDCL KFVSSHAFGVCVMALSSYDEKVRAAAYHVLSSFYHHLEGARFREKRQLLY LMDTVKN------------------------------------------- ---------------------GITQQNQRLPFVLTTYICKVAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYGFDL----------------- -----------EHKIEREWILNVLEEGISDGHCYELCNQQGIFQILLGFS SSPLCDDHFQ-------AQIIRVLSKASCANKAAYNLTKSSALLTWIIQV VEK-RNL----GQQLLCAVIDLLHVLWFTNLGQK-------------D-K Q--VDGAK-ATSSAGEKPQSR--------------------------VKC LPLPLINEFLCVAASISRHISR---LGVKAAQLSLFLQTLCSVLKH---- ---------RRTALSVSKQADRLTLHPQPLSSIEAITLLHCWASL----- ------------SHNTALLTQVQALCEKHKVKEC-----IG--------- ----------------------------TGKEKARGK------------- ------SLxxxxx------------------------------------- -------------------------------------------------- -----------------------------TQKENLAEDSE---------- ----------------------TEQHKERL---------LTECKFYLTGI FVHWEPACH----------------------------------------- -------------------------------------------------L FEPQTAQPRDKLDPSWLASDTAHLLTKW--------------------SL RWLVE--DLYDENRTKEFLHWVEKAVIKHKQVVDVVLVDLGWKADLLRLY HQAFETLQHASISP--------------------------REGTLQMFTN IMT------------------CLLEAQG-NLPE--L-------------- -----------------HQA----------------------VVSA---- ----------CRPEPGH-DQSRH-D--------SG--------------- ------------LFLLSLYIHDMWSGATSAELFLSHVSLV---------- ----TRVKC-KT---------------------------QKSSKS-PxTP DVI----------------------RAIC-----------SDIITMK--- --------S----- >ENSACLP00000036715 -------------------------------------------------- -----MG-------------------KKRRNDES-AESDTPRKKETI--- ------------------PEFNGTVFKAMLKDPTTAMK------------ -------------------G------------------------------ -----------------------------------------------LEK FISTAKKLPRSDLYDVVEGYIKISMECAEIFKLLEGEKHVESEMMLIFGS LEAILLRTASDLSHFNMVGNAIVKKTVFSYMKLLQGSFRSANHRFIRQCL GLLCALVTQGPEAAREVLSHLHINKFLSGLAKMKDKQGRPDVRQAFIQFV LSFVVSGDNATVGQILEIKELLPVILNTGLKEDRMSTVNLILSTLKTKVV LNKAISKTQKVRFFTPAVLASIASLYKWNGIADATVDDDR--MSENTELS GMTVIRELAHSFLLDLCCSRKHGISFHDVSFGTAGRPGNIVLLQFLVGLK QATEDELVADLVVNVLKATPDILSRYFKETQYAYAPRLKTTWQDNVKLLK KIYEAQPEISTVFQTQEVIPLPRLLSMVMVISLPPVCNKSFFTQGLILA- --------------------------------------NTGAHLTTLSVV NFILKRASKNIEYLLDKSVWCSSDLYTAEMMEDLVQQYREMLGKILPDMT SIIEKWQS-----------------------------LSKKE-------- -------------------------KAGSEEKxxxxxx------------ ----------------------------------------------xxxx ----------------xx----xxxxx-------EDTAEVILLKALILQV LCLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGIKDEVPPVLQHH VLQLALDLPASKFSWFRM-------------------------------- ---------QGAADK----D-SSSGEKSVFYLLLKMFV-SSS-SSHLKAS TQMLVLKVLKDTGVFEHTWTELELWLEQLARLEPNQQETVIQFLERVLVK LVCSSYEYTDKVASLVQEAGYLQANLSSQEGDTASVPVSHI--------- ---------D---------------------------------------- --DVIDMLDIIMEASDGELEEFGPAVSEDLIMQTFPFSALVPAALEARNK L-----------P----AxS-------G--------MVYEYLAAVLSDVL HCQREPLPLCLALLQYDKEFVS-SECFTSPHS---AIVCFHQYYSKWLPQ QCREEL-------------------------------------------- -----------FRS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxLSDQTSYT-------------ALMKAA YIQGPDT----------------LLKDTFRKSAEEALASLSLAEFPVAIK QILLYIRSTVENFG---------LFSKDVGASVLR---------TFMEIL EKMVIKLQGFQEAKN--------Sxx------------------------ -----------------------AxxxCQxx------------------- --------------x-----------DL-----------FLELNQSSTVE -------------VNIQQILLSALGSVFKHPYLEQWFLALELSAMPPHSL NPVRLKHLCSLMTDNILVLLKLCAPVLQELNHLELLRSYMGALERAALQE L--------VEK----GSKPAKKHSRTFQGLLSLHNYMDSGNLREVVSKL LLLPHNSLIS----------PxSSKGANFELSIYGQAALQILTECKYTAS QDHG--TFLTQ--------------------------------------- ---AHLFGLGTLLLSCSKPALEAFLLQFLSSEPSSAKLLHTDVLLHCL-- ------Q----RPLSDSLAISSLLLQNCSTHRLRFEMWCLE--------P ENMEKLSDQSEAF---LPLINMYLRVASREDPARPKD------------- -------------------------------------------------- --------------------VQKDILKALKQGLLAK-------------- ------------------------------------------------FS QCVLGNLTEESGAQL--TETLGSLIKLSANSKDIGDLINSLP-------- ----SALQNVDSF-E------RWQLVDVISDKLADCPEEQEKWRKSVATA AIKCLIASY-------------------------------SHSKDQ---- --------------ATSPLEQEHSILKRL-QRVLI----SKENIT----- -------------ASEWNNFVKNGLKYRYRD------------------- ---------------------HHFLNTLSSLLEVMYCGTEVQKDLIPLPT LYTMISSHSLFLPTMLDSEEAx-S-xQIK--------------------- --------------------------------------------EELVFL LLCLVKKSPSVCNINHFVVLLGAYGATLSTSDQKLLLLLQEYERNQVSLL KF--Q---------------------------SLLWGPTAVEHHKTSKSL GASLWKQTSSDDLLALLKPEKMLQTIAHFPQQRKIIPQ------------ ---------------------ESTEPLYNNNK------------------ -------------------------------V------------KDLGNL YDPCFLLP----LFSAILRP-----------------------ECVIDCL KFVSSHALGVTVMALSSYDPKVRAAAYHVLSCFYQHLEGAQFREKRQLLY LMDMVKN------------------------------------------- ---------------------GIQQQNQRLPFVMTTYITKVAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYSFDL----------------- -----------EHKVEREWILSVLEQGMKDGHCYDLCNQQGIFQILLGFS SSPLCDEHFQ-------AQIIRVLCQAARVTKAAHNLTKTSGLLTWIMQI VEK-RNL----DWQLLCAIIDLFHVLWFTALGQK-------------E-K Q--VDEAK-TSLSAEEKPQSF--------------------------VKC LPPPLISEFLCVASTITRHL-G---LGLKTAQLSLFLQTLCSVLKH---- ---------RATALHVSKQADRLTLQPQPLSCTEALALLHCWASS----- ------------SHNTELLTQIQALSEKHKVKEV-----MG--------- ----------------------------MRKDKARVK------------- ------Sxxxxxx------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxx---------- ----------------------xxNEDKSL---------LTECKLYLTNI FVHWEPAFQ----------------------------------------- -------------------------------------------------L CxxxxxxxTDKLDPSWLARITAHLVTKW--------------------SL RCLVE--DAYDENRAKEFLLWLEKAVIKHTKIVDVVLLDLGLKADLLRLY HQAFEAHCHSSISA--------------------------RAETLQLFTK IMI------------------SLLEIQG-xxxE--L-------------- -----------------HQA----------------------VVSA---- ----------CIPEATH-DQTRL-E--------AG--------------- ------------LSLLSLYIHEVWSGATSADLFLSHVSLV---------- ----TGAKC-KKxxx-------------xxxxx-----x----------- --I----------------------RAIC-----------NDIITMK--- --------S----- >ENSHBUP00000021953 -------------------------------------------------- -----MG-------------------KKRRNDES-AESDTPRKKETI--- ------------------PEFNGTVFKAMLKDPTTAMK------------ -------------------G------------------------------ -----------------------------------------------LEK FISTAKKLPRSDLYDVVEGYIKISMECAEIFKLLEGEKHVESEMMLIFGS LEAILLRTASDLSHFNMVGNAIVKKTVFSYMKLLQGSFRSANHRFIRQCL GLLCALVTQGPEAAREVLSHLHINKFLSGLAKMKDKQGRPDVRQAFIQFV LSFVVSGDNTTVGQILEIKELLPVILNTGLKEDRMSTVNLILSTLKTKVV LNKAISKTQKVRFFTPAVLASIASLYKWNGIADATVDDDR--MSENTELS GMTVIRELAHSFLLDLCCSRKHGISFHDVSFGTAGRPGNIVLLQFLVGLK QATEDELVADLVVNVLKATPDILSRYFKETQYAYAPRLKTTWQDNVKLLK KIYEAQPEISTVFQTQEVIPLPRLLSMVMVISLPPVCNKSFFTQGLILA- --------------------------------------NTGAHLTTLSVV NFILKRASKNIEYLLDKSVWCSSDLYTAEMMEDLVQQYREMLGKILPDMT SIIEKWQS-----------------------------LSKKE-------- -------------------------KAGSEEKKDKSEG------------ ----------------------------------------------xxxx ----------------xx----xxxxA-------EDTAEVILLKALILQV LCLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGIKDEVPPVLQHH VLQLALDLPASKFSWFRM-------------------------------- ---------QGAADK----D-SSSGEKSVFYLLLKMFV-SSS-SSHLKAS TQMLVLKVLKDTGVFEHTWTELELWLEQLARLEPNQQETVIQFLERVLVK LVCSSYEYTDKVASLVQEAGYLQANLSSQEGDTASVPVSHI--------- ---------D---------------------------------------- --DVIDMLDIIMEASDGELEEFGPAVSEDLIMQTFPFSALVPAALEARNK L-----------P----ADS-------G--------MVYEYLAAVLSDVL HCQREPLPLCLALLQYDKEFVS-SECFTSPHS---AIVCFHQYYSKWLPQ QCREEL-------------------------------------------- -----------FQS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SECHAKGLSDQTSYT-------------ALMKAA YIQGPDT----------------LLKDTFRKSAEEALASLYLAEFPVAIK QILLYIRSTVENFG---------LFSKDLGASVLR---------TFMEIL EKMVIKLQGFQQAKN--------SEL------------------------ -----------------------AVxKCQxx------------------- --------------x-----------DL-----------FLELNQSSTVE -------------VNIQQILLSALGSVFKHPYLEQWFLALELSAMPPHSL NPVRLKHLCSLMTDNILVLLKLCAPVLQELNHLELLRSYMGALERAALQE L--------VEK----NSKPAKKHSRTFQGLLSLHNYMDSGNLREVVSKL LLLPHNSLIS----------PxSSKGANSELSIYGQAALQILTECKYTAS QDHG--TFLTQ--------------------------------------- ---AHLFGLGTLLLSCSKPALEAFLLQFLSSEPSSAKLLHTDVLLHCL-- ------Q----RPLSDSLAISTLLLQNCSTHRLRFEMWCLE--------P ENMEKLSDQSEAF---LPLINMYLRVASREDPARPKD------------- -------------------------------------------------- --------------------VQKDILKALKQVLLAK-------------- ------------------------------------------------FS QCVLGNLTEESGAQL--TETLGSLIKLSANSKDIGDLINSLP-------- ----SALQNVDSF-E------RWQLVDVISDKLADCPEEQEKWRKSVATA AIKCLIASY-------------------------------SHSKDQ---- --------------ATSPLEQEHRILKRL-QRVLI----SKEDIT----- -------------ASEWNNFVKNGLKYRYRD------------------- ---------------------HHFLNTLSSLLEVMYCGTEVQKDLIPLPT LYTMISSHSLFLPTMLDSxxxx-x-CQIK--------------------- --------------------------------------------EELVFL LLCLVKKSPSVCNINHFVVLLGAYGATLSTSDQKLLLLLQEYERNQVSLL KF--Q---------------------------SLLWGPTAVEHHKTSKSL GASLWKQTSSDDLLALLKPDKMLQTIAHFPQQRKIIPQ------------ ---------------------ESTEQLYNNNK------------------ -------------------------------V------------KDLGNL YDPCFLLP----LFSAILRP-----------------------ECVIDCL KFVSSHALGVTVMALSSYDPKVRAAAYHVLSCFYQHLEGAQFREKRQLLY LMDMVKN------------------------------------------- ---------------------GIQQQNQRLPFVMTTYITKVAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYSFDL----------------- -----------EHKVEREWILSVLEQGMKDGHCYDLCNQQGIFQILLGFS SSPLCDEHFQ-------AQIIRVLCQAAHVTKAAHNLTKTSGLLTWIMQI VEK-RNL----DWQLLCAIIDLFHVLWFTALGQK-------------E-K Q--VDEAK-TSLSAEEKPQSF--------------------------VKC LPPPLISEFLCVASTITRHL-G---LGLKAAQLSLFLQTLCSVLKH---- ---------RATALHVSKQADRLTLHPQPLSCTEALALLHCWASS----- ------------SHNTELLTQIQALSEKHKVKEV-----MG--------- ----------------------------MRKDKARVK------------- ------SSxxxxx------------------------------------- -------------------------------------------------- -----------------------------VRKEKLAEDTE---------- ----------------------TENEDKSL---------LTECKLYLTNI FVHWEPAFQ----------------------------------------- -------------------------------------------------L CEPQPALPTDKLDPSWLARITAHLVTKW--------------------SL RCLVE--DAYDENRAKEFLLWLEKAVIKHTKIVDVVLLDLGLKADLLRLY HQAFEAHCHSSISA--------------------------RAETLQLFTK IMI------------------SLLEIQG-NLPE--L-------------- -----------------HQA----------------------VVSA---- ----------CIPEATH-DQTRL-E--------AG--------------- ------------LSLLSLYIHEVWSGATSADLFLSHVSLV---------- ----TGAKC-KKxxx-------------xxxxx-----x----------- --I----------------------RAIC-----------NDIITMK--- --------S----- >ENSPNYP00000014265 -------------------------------------------------- -----MG-------------------KKRRNDES-AESDTPRKKETI--- ------------------PEFNGTVFKAMLKDPTTAMK------------ -------------------G------------------------------ -----------------------------------------------LEK FISTAKKLPRSDLYDVVEGYIKISMECAEIFKLLEGEKHVESEMMLIFGS LEAILLRTASDLSHFNMVGNAIVKKTVFSYMKVLQGSFRSANHRFIRQCL CLLCALVTQGPEAAREVLSHLHINKFLSGLAKMKDKQGRPDVRQAFIQFV LSFVVSGDNVTVGQILEIK----VILNTGLKEDRMSTVNLILSTLKTKVV LNKAISKTQKVRFFTPAVLASIASLYKWNGIADATVDDDR--------LS GMTVIRELAHSFLLDLCCSRKHGISFHDVSFGTAGRPGNIVLLQFLVGLK QATEDELVADLVVNVLKATPDILSRYFKETQYAYAPRLKTTWQDNVKLLK KIYEAQPEISTVFQTQEVIPLPRLLSMVMVISLPPVCNKSFFTQGLIV-- -----------------------------------------THLTTLSVV NFILKRASKNIEYLLDKSVWCSSDLYTAEMMGDLVQQYREMLGKILPDMT SIIEKWQS-----------------------------LSKKE-------- -------------------------KAGSEEKKDKSEG------------ ----------------------------------------------xxxx ----------------xx----xxxxx---------STEVILLKALILQV ICLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGIKDEVPPVLQHH VLQLALDLPASKFSWFH--------------------------------- --------------K----D-SSSGEKSVFYLLLKMFV-SSS-SSHLKAS TQMLVLKVLKDTGVFEHTWTELELWLEQLARLEPNQQETVIQFLERVLVK LVCSSYEYTDKVASLVQEAGYLQANLSSQEGDTASVPVSHI--------- ---------D---------------------------------------- --DVIDMLDIIMEASDGELEEFGPAVSEDLIMQTFPFSALVPAALEARNK L-----------P----ADS-------G--------MVYEYLAAVLSDVL HCQREPLPLCLALLQYDKEFVS-SECFTSPHS---AIVCFHQYYSKWLPQ QY------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xTSYT-------------ALMKAA YIQGPDT----------------LLKDTFRKSAEEALASLSLAEFPVAIK QILLYIRSTVENFG---------LFSKDVGASVLR---------TFMEIL EKMVIKLQGFQEAKN--------Sxx------------------------ -----------------------x-------------------------- -------------------------------------------------- ------------------ILLSALGSVFKHPYLEQWFLALELSAMPPHSL NPVRLKHLCSLMTDNILVLLKLCAPVLQELNHLELLRSYMGALERAALQE L--------VEK----GSKPAKKHSRTFQGLLSLHNYMDSGNLREVVSKL LLLPHNSLIS----------PxSSKGANFELSIYGQAALQILTECKYTAS QDHG--TFLTQ--------------------------------------- ---AHLFGLGTLLLSCSKPALEAFLLQFLSSEPSSAKLLHTDVLLHCL-- ------Q----RPLSDSLAISSLLLQNCSTHRLRFEMWCLE--------P ENMEKLSDQSEAF---LPLINMYLHVASREDPARPKD------------- -------------------------------------------------- --------------------V-----------LLAK-------------- ------------------------------------------------FS QCVLGNLTEESGAQL--TETLGSLIKLSANSKDIRDLINSLP-------- ----SALQNVD---------------NVISDKLADCPEEQEKWRKSVATA AIKCLIASY-------------------------------SHSKDQ---- --------------ATSPLEQEHSILKRL-QR--x----SKEDIT----- -------------ASEWNNFVKNGLKYRYRD------------------- ---------------------HHFLNTLSSLLEVLYCGTEVQKDLIPLPT LYTMISSHSLFLPTMLDSxxxx-x-CQIK--------------------- --------------------------------------------EELVFL LLCLVKKSPSVCNINHFVVLLGAYGATLSTSDQKLLLLLQEYERNQVSLL KF--Q---------------------------SLLWGPTAVERHKTSKSL GASLWKQTSSDDLLALLKPDKMLQTIAHFPQQRKIIPQ------------ ---------------------ESTEPLYNNNK------------------ -------------------------------V------------KDLGNL YDPCFLLP----LFSAILRP-----------------------ECVIDCL KFVSSHALGVTVMALSSYDPKVRAAAYHVLSCFYQHLEGAQFREKRQLLY LMDMVKN------------------------------------------- ---------------------GIQQQNQRLPFVMTTYITKVAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYSFDL----------------- -----------EHKVEREWILSVLEQGMKDGHCYDLCNQQGIFQILLGFS SSPLCDEHFQxxxxxxx---------AAHVTKAAHNLTKTSGLLTWIMQI VEK-RNL----DWQLLCAIIDLFHVLWFTALGQK-------------E-K Q--VDEAK-TSLSAEEKPQSF--------------------------VKC LPPPLISEFLCVASTITRHL-G---LGLKAAQLSLFLQTLCSVLKH---- ---------RAAALHVSKQADRLTLQPQPLSCTEALALLHCWASS----- -------------------------------------------------- ------------------------------KDKARVK------------- ------SSxxxxx------------------------------------- -------------------------------------------------- -----------------------------VRKEKLAEDTE---------- ----------------------TENEDKSL---------LTECKLYLTNI FVHWEPAFQ----------------------------------------- -------------------------------------------------L SELQPALPTDKLDPSWLARITAHLVTKW--------------------SL RCLVE--DAYDENRAKEFLLWLEKAVIKHTKIVDVVLLDLGLKADLLRLY HQAFEAHCHSSISA--------------------------RAETLQLFTK IMI------------------SLLEIQG-NLPE--L-------------- -----------------HQA----------------------VVSAxx-- ---xxxxxxx--------------E--------AG--------------- ------------LSLLSLYIHEVWSGATSADLFLSHVSLV---------- ----TGAKC-KKxxx-------------xxxxx-----x----------- --I----------------------RAIC-----------NDIITMK--- --------S----- >ENSONIP00000007048 -------------------------------------------------- -----MG-------------------KKRRNDES-AESGTPRKKETI--- ------------------PEFNGTVFKAMLKDPTTAMK------------ -------------------G------------------------------ -----------------------------------------------LEK FMSTAKKLPRSDLYDVVEGYIKISMECAEIFKLLEGEKHVESEMMLIFGS LEAILLRTASDLSHFNMVGNAIVKKTVFSYMKLLQGSFRSANHRFIRQCL SLLSALVTQGPESAREVLSHLHINKFLSGLAKMKDKQGRPDVRQAFIQFV LSFLVSGDNATVGQILEIKELLPVILNTGLKEDRMSTVNLILSTLKTKVV LNKAISKTQKVRFFTPAVLASIASLYKWNGIADATVDDDR--MSENTELS GMTVIRELVHSFLLDLCCSRKHGISFHDVSFGTAGRPGNIVLLQFLVGLK QATEDELVADLVVNVLKATPDILSRYFKETQYAYTPRLKTTWQDNVKLLK KIYEAQPEISTVFQTQEVIPLPRLLSMVMVISLPPVCNKSFFTQGLILA- --------------------------------------NTAAHLTTLSVV NFILKRASKNIEYLLDKSVWCSSDLYTAEMMEDLVQQYREMLGKIFPDMT SIIEKWQS-----------------------------LSKKE-------- -------------------------KAGSEEKKDKSKG------------ ----------------------------------------------xxxx ----------------xx----xxxxD-------EDTAEVILLKALILQV ICLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGIKDEVPPVLQHH VLQLALDLPASKFSWFRM-------------------------------- ---------QGAG------x-SSSGEKSVFYLLLKMFV-SSS-SSHLKAS TQMLVLKVLKDTGVFEHTWTELELWLEQLARLEPSQQETVIQFLERVLVK LVCSSYEYTDKVASLVQEAGYLQANLSSQEGDAASVPVSHI--------- ---------D---------------------------------------- --DVIDMLDIIMEGSDGELEEFGPAVSEDLIMQTFPFSALVPAALEARNK L-----------P----ADS-------G--------TVYEYLAAVFSDVL HSQREPLPLCLALLQYDKEFVS-SECSTSPHS---AIICFHQYYCKWLPQ QCREEL-------------------------------------------- -----------FQS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SECHAKGLSDQTSYT-------------ALMKAA YIQGPDT----------------LLKDTFRKSAEEALASLSLAEFPVAIK QILLYIRSTVESFG---------TFSKDVGASVLR---------TLMEIL KKMVIKLQGFQEAKN--------SEL------------------------ -----------------------A-------------------------- --------------xx---xxxxEGSDL-----------FLELNQSSTVE -------------VNIQQILLSALGSILKHPCLEQWFLALELSAMPPHSL NPVRLKHLCALLTDNILVLLKLCAPVLHELNHLELLRSYMGALERAALQE L--------VEK----GSKPAKKHSRTFQGLLSLHNYMDSSNLKEVVSKL LLLPHDSLIS----------PxSSKGANFELSIYGQAALQILTECKYTAS QDHG--TFLTQ--------------------------------------- ---PHLFGLGTLLLSCSNPALEAFLLQFLSSEPSSAKLLHTDVLLHCL-- ------Q----RPLSESLAISSLLLQNCSTHRLRFEMWCLE--------P ENMEKLSDQSEAF---LPLINMYLHVASREDPARPKD------------- -------------------------------------------------- --------------------VQKDILKALKQVLLAK-------------- ------------------------------------------------FS QCVLGNLTEESGAQL--TETLGSLIKLSANIKDIRDLINSLP-------- ----SALQNVDSF-E------RWQLVDVISDKLADCPEEQEKWRKSVATA AIKCLIASY-------------------------------SHSKDQ---- --------------ATSPLQQEHSILKRL-QRVLI----SKEDIT----- -------------ASEWNSFVKNGLKYRYRD------------------- ---------------------HHFLNTLSSLLEVMYCGTEVQKDLIPLPM LYTMISSHSLFLPTMLDSxxxx-x-CQIK--------------------- --------------------------------------------EELVFL LLCLVKKTPSVCNINHFVVLLGAYGATLSTSDQKLLLLLQEYERNQVSLL KF--Q---------------------------SLLWGPTAVEHHKTSKSL GASLWKQTSSDDLLALLKPDKMLQTIAHFPQQRKIIPQ------------ ---------------------ESTDPLYNNYK------------------ -------------------------------V------------KDLGNL YDPCFLLP----LFSAILRP-----------------------ECVIDCL KFVSSHALGVTVMALSSYDPKVRAAAYHVLSCFYQHLEGARFREKRQLLY LMDMVKN------------------------------------------- ---------------------GIQQQNRRLPFVMTTYITKVAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYSFDL----------------- -----------EHKVEREWILSVLEQGMKDGHCYDLCNQQGIFQILLGFS SSPLCDEHFQ-------AQIIRVLCQAANVTKAVHNLTKTSGLLTWIMQI VEK-RNL----DWQLLCAIIDLFHVLWFTALGQK-------------E-K Q--VDETK-TSLSADEKPQSF--------------------------VKC LPLPLISEFLCVASTIMRHL-R---LGLKAAQLSLFLQTLCSVLKH---- ---------RAAALHVSKQADRLTLHPQPLSCTEALALLHCWASL----- ------------SHNTELLTQIQALSEKHKVKEL-----MG--------- ----------------------------MGKDKARVK------------- ------SSxxxxx------------------------------------- -------------------------------------------------- -----------------------------TRKEKLAEDTE---------- ----------------------TANDDKSL---------LTECKLYLTNI FVHWEPAFQ----------------------------------------- -------------------------------------------------L SEPQPALPTDKLDPSWLARITAHLVTKW--------------------SL RCLVE--DSYDENRAKEFLLWLEKAVIKHTKIVDVVLLDLGLKADLLRLY HQAFEAQCHSSISA--------------------------RVETLQLFTK IMI------------------SLLEIQG-NLPE--L-------------- -----------------HQA----------------------VVSA---- ----------CSPEATH-DQTRL-E--------AG--------------- ------------LSLLSLYIHEVWSGATSADLFLSHVSLV---------- ----TTAKC-KKxxx-------------xxxxx-----x----------- --I----------------------RAIC-----------NDIITMK--- --------S----- >ENSGACP00000015492 -------------------------------------------------- -------------------------------------------KKEV--- ------------------PEFNGTVFKAMLKEPTTAMK------------ -------------------G------------------------------ -----------------------------------------------LET FISTAKKLPCPDVYDVVEGYIKISMECAEIFKLLDGEKNIASEMMPIFES LEMILLRTASDLSHFSMVGNAVVKKILSSYVKLLQTSFQSENHRFVRQCL SLLSASVSQGPEAAREVLSHIHINKALSGLARRKDKKGRPDVRMAFIQFV LSFLVSGDIATVGQILESKELLPEILSTGLKEDRMSIVNLILSTLRTRVV LNKAITKTQKVRFFTPALLANIASLYKWNGIVDATTDDDR--MSEDPEHA AISVIRELVHGFLLDLCCSRKHGIIFHDASFGTAGRAGNIVLLQFLAGQK QATEDELVAELVVNVLKACPDMLARYFKESQYSYTPRLKSAWQDNVKLLK KIYEAQPDISSVFQSCELIPLPRLLSMIMVISLPPVCNKTFFTQGLSLC- --------------------------------------NTAVQLTTLTTM HFILKRANKNMEYLMKESEWHSSDVYTLDMMEDLVLRYRETLSKILPDTT ALVSKWQL-----------------------------LSKKE-------- -------------------------KTEDEESKTKTEGGVxxxx--x--- -------------------------------------------------- -----------------------xxxx-------PETAEVILLKTLILQV LCLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMREGVPPVLQYQ ILQLALELPASKFSWFHI-------------------------------- ---------QDVADT----E-PSSGEKSVLYLLLKMFV-SSS-SSHLTTS TRMLVLKVLKDSGVFDYTWTELEIWLDQLARLEERQQEIVIQFLERVLVR LVCNSYTYTDKVASLVQEAAYLQANLSGPDGDAVSIPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGNEGEMEELGPSLNEDLITQTFPFSGMVPAALEARNK L-----------S----IGT-------G--------VVFEYLSAVLSDVL HCQREPLPLCLALLQYDKELVS-AEHSASPHP---SVIHLHQYYSQWLPQ PCREQL-------------------------------------------- -----------FPS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SECDSMVLSTHTSFN-------------ALMKSA YSQGPNT----------------LLEVTFKENVDGALASMSMADFPVAIK QMLLYIKSTVENIG---------TFSKDTGTAPLK---------ALMGIL LDLVIKLHSFEESTS--------SEP------------------------ -----------------------AAxNSP--------------------- -----------------------EGSNL-----------FLEINQSSTVE -------------GNKEKIVVSALGSIFKHPCFEQWFLALELAALPPHTL NPVRLKRLCAQLSDGILALLKSSTPALSDLGGLGLISSYVGAIEKAVLKE Lx-----xxVES----GSPAPNKHSRPFQALLSLHRYMDPCNLREVVSKL LLLPQDSLIS----------P------RAELSVYGDAALQILTESKANPS QEHG--ICLSQ--------------------------------------- ---AHLHGLSTLLLSCSSSALEAFLLHTLSGEPYRAKLIHTDVLLHCL-- ------Q----WPRPGTQAISSLLLQNCSTHRLCFEMWCLE--------P TNTEKLSNQTETF---LPLINTYLQVARREDPARPKD------------- -------------------------------------------------- --------------------VQKKVVKALKQALLAN-------------- ------------------------------------------------LS RCVLGNLTEDSGAQL--AVTLTNLIELSESIKDTGDLISSLP-------- ----SALQKVDSF-E------RWQLVDVITEKLSDCPEEQDTWRKSVTTA ALKCLIATF-------------------------------SRSKDE---- --------------DTLWSEQERSLLERL-QGLLT----SPEDIT----- -------------ASEWNSFVKNGLKYRYRD------------------- ---------------------PHFLNTLSNLLEVMYSSSEVHKDLIPLST LHMMTSSHSLFLPTMLDCAEDS-SVRQAK--------------------- --------------------------------------------EALVSL LLRLVKQSPTVCNMNHFVVLLGAYGVTLSTSDQKILMLLQEYERNDVSLL KFHYR---------------------------SFLWGPAAVEHHKTRKSL GASLWKQTSSDDVLALLKSDKMLQTIAHFPQQRRIIRQ------------ ---------------------DNKERLYCNNA------------------ -------------------------------M------------KDLENL YDPRFLLP----LFSSILQP-----------------------ECVIDCL KFVSSHAFGVTVMALSSYDSKMRAAAYHVLSCFYQHLEGARFREKRQLLY LMDIARN------------------------------------------- ---------------------GIRQQNQRLPFLLTTYITKAAQQMLKPED HMYMVLNRFLLSHQSLDFKRVPEFFKLFYGFDL----------------- -----------EHKMEREWILSVLEEGISDSLCYELCEQQGIFQTLLGFG SSPLCDERCQ-------AQIIRVLCQAARVTRAAYNLTKSCGLLTWIVQM VEK-RNL----DQQLLSAIINLLHVLWFTNLGEK-------------E-K ExxVDEAE-ASSSTGEKPQSS--------------------------VKC LPLPLICEFLCVASTISSHL-R---LRMKAAQLNLFLQTLCSVLKH---- ---------CETAVNANKRAQWLTLHPQPLSCTEALTLLRCWASL----- ------------SRNTALLAQIQALSEKHKVREL-----LE--------- ----------------------------IRKDKAR--------------- ------xSxxxxx------------------------------------- -------------------------------------------------- -----------------------------TRKEILADDAD---------- ----------------------TEKQEESL---------LTECKRYLGSI LVHWEPVFP----------------------------------------- -------------------------------------------------L SEAQPDETRDKLDPSQLAGDTAHLLTKW--------------------CL RCLVE--GSYDGKRTNEFLHWVQKAVMEHSEMVTAVLLDSDMKADFLRLY NQAFEAQCSFSLSA--------------------------RAETLQLFTT IMI------------------RLLEAQG-ELPE--Q-------------- -----------------HQT----------------------VVSA---- ----------CLPEDTP-DPSRR-E--------AG--------------- ------------LFLFSSYIHELWSGAASAELFLSHVSLV---------- ----TRAKS-KK---------------------------RNASKS-PxTP AAV----------------------TALC-----------HDIMTMKx-- -------xx----- >ENSMALP00000025223 ---------xxxxxxxxxx------------------------------- -------------------------------EDS-VESDAPVKKEKV--- ------------------PEFNGTVFKAMLKDPTTAMK------------ -------------------G------------------------------ -----------------------------------------------LET FISIAKKLPCSDLYDVVEGYVKISMECAEIFKLLEGEKHVESEMMLIFES LEMILLRTASDLSHFNMVGNAVVKKIVSSYVKLLQGSFHSQNHRFVRQSL SLLSALVSQGPEAAREILSHIHINKSLSGLAKRRDKKGRLDVRMAFIQFV LSFLVSGDNAAVGQILENKELLPEILSTGLKEDRMSVVTLILSTLKTTVV LNKAISKTQKVRFFTPAVLANIASLYKWNGIVDTVE--------xSSEHA GISVVRELVHSFLLDLCCSRKHGISFHDPSFGTSGRAGNIVLLQFLVGLK QATEDELVAELVVNVLKASPDILARYFKETQYSYTPRLKSAWQDNVKLVK RIYEAQPELCTVFRTCEVISLPRLLSMIIVTSLPPVCNKAFFTQGLNFA- --------------------------------------NTAVQLTTLSMM SFILKRANKNIEYLLDKSEWHGSDVYTLDMMGELVQQYRETLSKILPDMT SIIAQWQS-----------------------------VSKKE-------- -------------------------KA----------------------- -------------------------------------------------- --------------------------x-------xxTAEVILLKALILQV ICLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMREEVPPVLQYQ ILQLALELPASKFSWFRI-------------------------------- ---------QDVGDT----E-SSSGEKSVLYLLLKMFV-x---SSYLKTS TRMLVLKVLKDSGVFEYTWTELELWLNQLARVEQSQQETVIQFMER--xS LVCNSYTYTDKVASLVQEAAYLQANLSSQEGDTASIPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGNDGEMEEFGQPLSEDLISQTFPFSVVVPAALEARNK Lxxxxxxxxxxx-------------------------VYEYLSAVLSDVL HCQKEPLPLCLALMQYNKELVSxxxSSASAHP---SIIHLHQYYSKWLPQ QCREELxx--------------xxx----------------xxxxx---- ----------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------VSFT-------------ELMKAA YIQGPST----------------LLDGTFRKNVEESLASVLLSDFPVAVS QILLYIKSTVDNFG------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xILVSTLASIFKHPCLEQWFLALELAALPPQTL NPIRLKHLCAQLSDDILALLKISAHTLRDLGHLELLGSYTGAIEKAVLKE L--------MDK----GSETTKKQSRPFKALLSLYSYMDSCNLREVVSKL LLLPHESLVS----------P-GTEGTQVQLSIYGHAALQILTDVQSN-S QDHS--TFLTQ--------------------------------------- ---AHLRGLGSLLLSCSSPALEAFLLQTLSSEPGSAKLIHTDVLLHCL-- ------Q----CPLPNTLAISSLLLQNSSTHRLCFEGWCLE--------P ANIEKVSDQTETF---LPLIGTYLQMASREDPTRPKD------------- -------------------------------------------------- --------------------VQKEVLKALKQGLLAR-------------- ------------------------------------------------LS RCVLGTMTEDSRALL--VETLSSLIKLTANIKDIRDLISNLPxx-----x xxxxx----------------RWQLVNVITEKLLSCPEEQETWRTSVTTA ALKCLIASY-------------------------------SHSKHC---- --------------AASPSEQEQSILERL-QRLLT----SPDDIA----- -------------ASEWNSFVKNGLKHRYRD------------------- ---------------------HCFLNTLSSLLELMYSNSDAQKDLIPLST LHMMISSHSLFLPTMLASDEEP-SICQAK--------------------- --------------------------------------------EALVSL LFCLVKKCPTVCNISHFVVLLGAYGAT----------------------- ---------xxxx-------------xxxxxxSFLWGPAAVEHHRTRKSL GASLWKQMGSDELLALLKPERMLQTIAHFPQHLSIIPQ------------ ---------------------DGDELPNSNKA------------------ -------------------------------V------------TNPGNL YDPRFLLP----LFSAILRP-----------------------ECVIDCL KFVSSHALGVTVMALSSYDPKVRAAAYHVLGCFYQHLEGARFREKRQLLY VMDTVKN------------------------------------------- ---------------------GIQRPNQRLSFVMTTYITKVAQLMLKPED HMYMVVNRFLLSHQWLEFRRVPEFFKLFYSFDL----------------- -----------QHKVEREWILNVLEEGISDGHSYELCNQQGIFQGLLGFS SSPLCDEHSQ-------TQIIRVLCHAARVARAAYNLTKCCGVLTWIIQV VEK--SL----DQQLLSAIIELLHVLWFTILGQK-------------Exx x--ADGAK-----TSEKPQSS--------------------------VNC LSLPLISEYLCVASTLSRHL-R---LGVKATHLSLFLHTLCSVLKH---- ---------RGTALNVKKQADQITLYPQPLSCTEVLNLLLCWASL----- ------------SHNTALLTHIQALSERHTVKEF-----LG--------- ----------------------------MGKDKARGK------------- ------GSxxxxx------------------------------------- -------------------------------------------------- -----------------------------TPKENLTKDDD---------- ----------------------SERQEESL---------LTECKIYLSSI FVHWEPVFP----------------------------------------- -------------------------------------------------L SESQSAHPKDKLDPGRLACDTAHLLIKW--------------------SL RFLVE--DSYHENRTKEFLHWVEKAVIKHREIVDVVLHDLGLKADLLRLY HQAFEAQCHSSISA--------------------------RVETLKRFTN IMI------------------RLLETKG-HL------------------- -----------------------------------------------xxx xxxxxx----x----------------xxx-------------------- -------------------------GATSAELFLFHVSLV---------- ----TRTKY-KR---------------------------HKASKS-SxTQ TAI----------------------RAIC-----------NDIITMK--- --------S----- >ENSMAMP00000016670 -------------------------------------------------- -----MS-------------------KKRRGEDS-SEPNTPVKKEKV--- ------------------PEFNGTVFKAMLKEPTTAMK------------ -------------------GE----------------------------- ----------------------------------------------xLGA FISTAKKLPCSDLYDVVEGYIKISMECAEIFKLLEGEKHLESEMMLIFES LEMILLRTASDLSHFNMVGNAIVKKMVSSHMKLLQGSFHSQNHRL---CI SLLSALVSQGPEAAREVLSHIHINKALSGLVKRKDKRGRPDVRMTFIQFV LSFLVSGDNATVGQILESKELLPEILSTGVKEDRLSIVSLILSTLKTRVV LNKAISKTQKVRFFTPAVLANIASLYKWNGTVDATTDDNR-----NSEHA GISVVRELVHSFLIDLCCSRKHGISFHDASFGTAGRAGNIVLLQFLVGLK QATDDELVADLVVNVLKASPDILARYFKETQYSYTPRLKSAWQDNVKLLR RIYEAQPEFSTIFRTLEVIPLPRLLSVITVTSVPPVCNKAFFTQGLNLA- --------------------------------------NTAVQFTTFSMM NFILKRANKNIEYLLDKSVWHNSDVYTHDMMEELVQQYRETLSKILPDMM SIVSTWQL-----------------------------LSRKD-------- -------------------------KGSGQENKTKAERAAxxxxxxx--- -------------------------------------------------- -----------------------xxx-----------AEVILLKALILQV ICLYQKVVPHLVNQCKFDFSKLLK-------------------------- -------------------------------SIMSEKGIREEVPPVLQYH ILQLALDLPASKFSWFRI-------------------------------- ---------QDVADT----E-SLSGEKSVLYLLLMMFV-STS-STHLKTS TQMLILKVLKDTGVFEYTWTELELWLNQLARIEPNQQETVIQFLERVLVK LLCSSYTYTDKVASLVQDAAFLQANLNSQEGDAASIPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGNNGEMEEFGPSLSEDLIIQTFPFSVLVPAALEARNK L-----------S----ADK-------Gxxxxxxxxx---YLSAVLSDVL HCQREPLPLCLALMQYDKEL------------------------------ -------xxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------PVSLT-------------ALMKDA YSQGPSA----------------LLKGTFRENMEGFLASMLLTDFPVVIK QILLYIKSTVEKFG----------------xxxLK---------TFMGIL QDLVTKLQGFQETTE--------SEP------------------------ -----------------------PAxNSE--------------------- -----------------------DGSDL-----------FLELRQSPTVE ------------------ILVSTLRSIFKHPCLEQWFLALELDTLPPQTL NPVRLKHLCAQLSDDILALLKTSAPTLCDMGHLEFLESYMTGIEKAVLKE L--------MEK----CSQVVKKQSRPFQALLSLHSYMDSCNVREVVSKL LLLPCESLIL----------P-GREATQAQLSVYGHAALQILTEYKSKx- QDHN--IFLTQ--------------------------------------- ---AHFHGLGTLLLSCSNPALEAFLLQTLSSEPGSAKLLHTDVLLHCL-- ------H----WPRPDTQGIGCLLLQNSSTHRLCFEMWCLQ--------P ANRQTILAQIETF---LPLISTYLQMASREDPARPKDxxxxx-------- ---------------xxxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- ----------------------SLIKLSANITDIRDLVNTLP-------- -------------------------------------xEQETWRKSVITA ALKCLIASY-------------------------------SRSKDQ---- --------------ATSPSEQEQSILERL-QQLLV-------NIT----- -------------ASEWNGFVKNGLKYRYRD------------------- ---------------------HHFLHTLRGLLDLMYSGGEVQKDLIPLST LHMMSSSHSLFLPTMLEPDEEP-SRFQAK--------------------- --------------------------------------------EGLVSL LLCLVKKCPTVCNIDHFVVLLGAYGATLNTTDQKLLQLLQEYERNHVSLL KF--Q---------------------------SFLWGPAAVEHHKTRKSL GSSLWKQASSDELLALLKPDRMLQTIAHFPQHHRIIPQ------------ -------------------------------------------------- ---------------------------------------------DLGKL YDPCFLLP----LFSAILRP-----------------------ECVIDCL KFVSSHALGVTVMALSSYDPQVRAAAYHVLSCFYQHLEGARFREKRQLLY LMDTVKN------------------------------------------- ---------------------GIRKQNQRLPFVLTTYITKVAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYGFDL----------------- -----------EHKVEREWILSVLEEGINDGHCYELCDQQGIFQILLGFS SSPLCDEHSQ-------AQIIRVLCQAARVPKAANNLTKSCGVLTWIIQV VEK-RNL----DQQLLSAIIDLLHVLWFTNLGQK-------------Exx x--GNGAK-TTSSTEEKPQSS--------------------------VKC LPLPLINEFLCVALTISRHL-R---LGLKPSQLRLFLQSFCSALKH---- ---------RETALNENKQAGRFTLHPQPLSCTEALSLLLCWASIxxxxx xxxxxxxxxxxxx---------------------------G--------- ----------------------------MRKDKARSK------------- ------GSxxxxx------------------------------------- -------------------------------------------------- -----------------------------TQKETLAEDTE---------- ----------------------DAKQEERL---------LAECKFYLRSI FIHWEPVFH----------------------------------------- -------------------------------------------------V SESQSVQSRDKLDPSQLACDTAHLLTKW--------------------SL RCLVE--DSYDVNRTKEFMHWVEKAVIKHKEIVDVVLLDPCVKADLLQLY HQAFEAQCQPSISS--------------------------RVETLQQFTN IMI------------------SLLETKS-HLPE--L-------------- -----------------HQT----------------------VISA---- ----------CLPKATH-DPSK--S--------AG--------------- ------------LCLMSLYIHELWSGATSAELFLSHVNLV---------- ----TRGKH-KR---------------------------QKESLx---TQ SAI----------------------RAIC-----------VDILTMKxxx x-----xxC----- >ENSTNIP00000019371 -------------------------------------------------- --------------------------------------------SKV--- ------------------TEFSGTTFKTMLKEPSSAMN------------ -------------------G------------------------------ -----------------------------------------------LKS FVSAAKKLPSSDVYDVVEGYIKISMECTEIFKLLEGEKHVETELILIFES LEMILLRTASDLSHFSMVGNAIVKKTVSGYMKLLQSSLHSTNHRFVRQCL GFLTALVSQGPEAAREVLNCIHVNKSLSGLAKRKDKQGRPDVRMAFVQFV LSFLVSGDNTTIGQVLEFKEFLPEILSTGIKEDRMSVVNLILSTLKTRVV LNKGISKTQKISFFSPVVLAHIASLYKWNGLVDVSTDDI---xEEDSDRA GISAVRDLVHSFLTDLCSSCKHGISFHDASYGTAGRPGNIVLLKFLVGLK QATEDGLVADLVVSVLKVCPDLLARYFQETQYSYTPRCKSAWQENVQLLK KIYDAQPEISTIFQTAEVIPLPRLLSMIMVVSLPPVCNKPFFTQGLSLT- --------------------------------------NTAAQLTTLSMT NFILKRANRNIEYLLEKSEWHSSKGYTHGMMEELLQQYREALSKILPDIT SVIAKWQS-----------------------------LSKKE-------- -------------------------KINDEEKNTPTEGSVxxxxxxx--- -------------------------------------------------- --------------------------x-------AETAEIVLLKALILQI ICLYQKVVPHLVSQCKFDFSKLLK-------------------------- -------------------------------GIVSDKGIREEIPPVLQYQ ILQLALDLPASKFSWFRI-------------------------------- ---------QDVADS----E--SSGEKSVLHLLLKMFV-SSS-SSHLRTS TRSLILKVLKDSGVFEYTWMELEIWLNQLTRVEPNQQETVIQFLERVLGK LVSSSYTYTDKVASLVQEAAYLQDNLSNPDGETASAPVSHI--------- ---------N---------------------------------------- --DVIDMLDVIMEGSEGEMQEFGPSLSEELILQTFPFSVLVPAALEARNK L-----------P----ADK-------Gxxxxx---VVLEYLSAVLLDVL HCQREPLPLCLALLQYDKELVS-SEPSVLPHP---SIISLHAYYSKWLPP QCQEKL-------------------------------------------- -----------FKP------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SEGCSRELSSSSSFT-------------ALMKAA YSQGVDT----------------LLKDAFRKKVEESLSSMMMAEYPVAVK QILLYIKSTLEIVG---------TLPKEMGIVPVR---------TLMGIL LDLVTKLKDFQENTN--------SEP------------------------ -----------------------MAxKLQ--------------------- -----------------------EGSEL-----------FLEINQLSPQE -------------AKKEQVLLSVLGAIFKHPCLEPWFLALELSALPPHRL NPVRLKQLCTQLNEDILALLKTSTPVLKNLAHLDLVSSYMGAIEKAVLKE V--------LEK----PSQGAKKQSKPFQALLSLHCYLDAVRLNEVISKL LLLPPESLIL----------P-RRKGTQAELSVYGHAAVQILT---ANSS LDRS--IFLSQ--------------------------------------- ---THLHGLGTLFLSCSSPTLEAFVLQTLSDEPGSAKLVNKDVLLHCF-- ------R----CPSHNTQAISSVLLQNCSTHLLCFEMWCLE--------P S------------------------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------xxxLS QCVLGDATENSITQQ--TEALSSLIKISANVSDIRNLMNKLP-------- ----TALQNVKNF-E------RWKLIDVITEKLADFPQEKETWRKSVVTA AIKCLIASY-------------------------------SSYKDQ---- --------------TTSPSEQERSILERL-CQHLS----SSEDIT----- -------------SSEWNTFVRNGLKYRFKD------------------- ---------------------HLFLNTLSSLLEVIYTDSEDHKDLVSLST IHMMASTHSLFLPTMLDSAEEP-K-xxxK--------------------- --------------------------------------------DALVSL LLCLVKKCPAVCTSNHFVVLLGAYGVTLSTLDQKILLLLQEYERNNVSLL KFxCR---------------------------AFLWGPAAVEHHKTRKSL GASLWKQVSSDNLLALLNTDRMLQTVANFPQQRKMMTQ------------ ---------------------ENKGLIYTDGA------------------ -------------------------------T------------KDLGNM YDPCFLLPxxxxx------------------------------ECVIDCL KFVSSHAMGVTVMALSSYDPKIRAAAYHVLSCFYQHLEGSQFREKSQLLY LMDMMRN------------------------------------------- ---------------------GIRHPNQRLPFVMTTYVAKVAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYGFDL----------------- -----------EHKMEREWILHVLEEGMRDGQCFELGDKQGIFQILMGFG SSPLCDEHCQ-------ALIMKVLLQAARVTRAAYNLSKSCGLLTWIIQM AER-KTV----DQQLLSAIIDLVHVLWFTILGQK-------------E-K Qx----------TADEKHQSS--------------------------VKC LPLPLINDFLCVALTISRHL-G---LCVRPAKLCLLLQTLCSVLRY---- ---------RKTALLLSTQAGRLTFPPQPLSSSEALSLLRCWAFL----- ------------AHNTALITQIQDICEKHHLKELxxxxSFS--------- ----------------------------VGKDKSQAK------------- ------Axxxxxx------------------------------------- -------------------------------------------------- -----------------------------SQRQNLAEDSE---------- ----------------------TEKQQRSY---------LAECKTYLCGI LVHWEPVIP----------------------------------------- -------------------------------------------------V SEPQLVNS--------------------xxxxxxxxxxxxxxxxxxxxCL RCLVE--EPYDENRTEEFLFWAKKAVLEHKEIMNVVLDDSGWRADLLRLH HHT-EVHCRSSIPS--------------------------RVETFQTFTD IMM------------------CLLEAKG-NLPV--L-------------- -----------------HQI----------------------VAAA---- ----------C-----Q-AKSRS-E--------AG--------------- ------------LFLLSLYVSEMWSGATATQMFLSHVSLV---------- ----x--------------------------------------------- ---xxxxxxxxxxxxxx-------xKAIC-----------EDISSSI--- --------S----- >ENSTRUP00000023566 -------------------------------------------------- -----MG-------------------KKRISGDS-GGSTPPEKIQKV--- ------------------MEFSGIAFKTMLKEPTSAMK------------ -------------------G------------------------------ -----------------------------------------------LEA FISAAKKLPSSDLYDVVEGYIKISMECTEIFKLLEGEKHLETELILIFES LEMILLRTASDLSHFSMVGNAVVKKTVSSYMKLLQSSLHSSNHRFVRQCL SFLTALVSQGPEAAREVLSCIHINKSLSGLAKRKDKKGRPDVRMAFVQFV LSFLVSGDNATIGQVLEFKELLPEILCTGIKEDRMSIVNLILSTLKTRVV LNKAISKTQKINFFTPALLANVASLYKWNGLVDLITDDN---xEEGSDHA GISAVRDLVHSFLTDLCSSRKHGISFHDASYGTAGRSGNIVLLKFLVGLK QATEDALVADLVVSVLKVCPDILARYFQETQYSYTPRCKSAWQENVQLLK KIYDAQPEISTIFQTAEVIPLQRLLSMILVVSLPPVCNKPFFTQGLNLA- --------------------------------------NTAVQLTTLSMI NFILKRAIKNIEYLLEKSEWHNSKGYTHDMTEELLQLYREALSKILPDIT SVIAKWQS-----------------------------LSKKE-------- -------------------------KMNDEGKNIPTEGSVxxxxxxx--- -------------------------------------------------- -----------------------xNxx-------AETAEVILLKALILQV LCLYQKVVPHVVSQCKFDFSKLFK-------------------------- -------------------------------GIVSDKGMREEVPPVLQYQ ILQLALELPASKFSWFRI-------------------------------- ---------QDVADS----E--SSGEKSVLYLLLKMFV-SSG-SSHLKTS TRSLILKVLKDSGVFEYTWTELEIWLNQLARVDPNQQETVIQFLERVLGK LVNSSYTYTDKVASLVQEAAYLQDNLSSQEGETASTPVSHI--------- ---------D---------------------------------------- --DIINMLDVIMESAEGEMQEFGPSLSEELILQTFPFSVLVPAALEARNK L-----------P----GNK------------x---VVFEYVSAVLCDVL HCQREPLPLCLALLQYDKELVS-SQPSASPHP---SIISLNEYYSKWLPR QCQEPL-------------------------------------------- -----------FKS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SEGCSGELSSPSSFN-------------ALMKAA YSQGMST----------------LLEDAFRKKVEETLSSISMAEYPVAVK QILLYINSTLENVG---------TFPKEIGIMPVR---------TLMGIL LDLVTSLKDHQESTN--------SVP------------------------ -----------------------TAxMPH--------------------- -----------------------EGSEL-----------FLEINQSSAEE -------------ANKEQILPSVLGSIFKHPCLKQWFLALELSALPPHTL KPVRLKHLCTQLNEDILALLKTSAPILHDLAQLDLVCSYMEAIEKSVLKE V--------MEK----SSEGAKKESKPFQALLSLHCYLDSFKLNEVVSKL LLLPKQSLIL----------P-MSKATQAELSVYGHAAVQILTQSKANSS LDRS--IFLSQ--------------------------------------- ---AHLHGLGTLFLSCSSPTLEAFLLQTLSDEPGSAKLITTDVLLHCF-- ------Q----YPSHNTLAIGSLLLQNCSTHLLCFEMWCLE--------P SNMEKLLDNMETF---LPLIVVYLQMASKEDPARPKD------------- -------------------------------------------------- --------------------VQKQVLKALNEGLLLN-------------- ------------------------------------------------LS KCVLGNMTENSRPQQ--TEALSSLIKLSAHTDDIRKLINNLL-------- ----SALQNVESF-E------RWKLIDVISEKLADFPEEKETWRKSVITA AIKCLTASY-------------------------------SNYKDQ---- --------------ATSP-EQERTVSERL-CQHFS----SSEDIA----- -------------ASEWNSFVKNGLKYRFKD------------------- ---------------------HHFLNTLRSLLEVIYTDSKDQKDLISLST IHMMTSTHSLFLPTMLDSGEEP-T-xxxK--------------------- --------------------------------------------EALVSL LLCLVRKCPAVCNNNHFVVLMGAYGVTLSTLDQKLLLLLQDYEKNNVSLL KF--Q---------------------------AFLWGPAAVEHHKTRKRL GASLWKQVGSDDMLALLNPDRMLQTVTHFPQRRKMMTQ------------ ---------------------EDKELLHTNSA------------------ -------------------------------V------------KDLGNL YDPCFLLP----LFSAILRP-----------------------ECVIDCL KFVSCHAMGVTVMALSSYDPKVRAAAYHVLSCFYQHLEGSQFREKRQLLY LMDTMKN------------------------------------------- ---------------------GIRQTNQRLPFVLTTYVAKVAQQMLKPED HMYVVLNRFLLSHQSLDFRRVPEFFKLFYGFDL----------------- -----------EHKMEREWILHVLEEGMSDGQCFDLCDKQGIFQILLGFS SSPLCDEHCQ-------AQIMKGLLRAAHVTRAAHNLTKSCGLLTWIIQM AER-NTV----DQQLLSVIIDLLHALWFTILGQN-------------E-K Qx----------MAAEKRQSS--------------------------VKC LPLPLINDFLCVALTISRHL-R---LRVRPGQLCLFLQTLCSVLKY---- ---------GRTAFSLNTEAGRFTLPPQPLSCSQVLSLLHCWASL----- ------------AHDTVLLTQLHELSEKHKL------------------- ----------------------------FGKDKIQAK------------- ------SHxxxxx------------------------------------- -------------------------------------------------- -----------------------------SPRQSLAEDSE---------- ----------------------IEKQESSP---------LMECKSYLCSI FVHWEPLIP----------------------------------------- -------------------------------------------------V SEPQLVNSPQGLAPSPLANDTAQLLSKW--------------------CL RCLVE--EPYDENRTKEFLFWAKKIVLEDKEIMNSLLDDSGWRANLLRLH HHT-DVYCHSSVPS--------------------------RVETLQIFTD IMI------------------CLLEAKG-NLPV--L-------------- -----------------HHA----------------------VVSA---- ----------CLSKSKQ-DQSRY-E--------AG--------------- ------------LFLFSLYISEMWSGATSAQMFLSHASLV---------- ----ARTKC-KI---------------------------KKTSQS-AxTQ IAI----------------------KAVC-----------DDIITST--- --------S----- >ENSXCOP00000007121 -------------------------------------------------- -----MS-------------------KKRPSDAP-VESEAPAKKEKA--- ------------------LEFNGTVFKTMLKNPTTAMK------------ -------------------G------------------------------ -----------------------------------------------LER FISTAKKLPSCDLYDVVEGYMKISMECAEIFKLLEAEKPLETEMMLIFGS LEVILLRTASDLSHFNMVGNVIVKKIASNYMKLLQGSFHSLNHGFVRQCL NLLSAMVSQGAEAAREVFSHVQI-KTLFGLAKRKDKRGKPDVRLAFIQFV LSFLVSGDSSIIGQVLEVKELLPQILNTGLKEDRMSTVNLILSTLKTRIV LNKAISKTQKVRFFTPAVLANIASLYKWNGIVD------------DSDAA GISVVRDLVHRFLVDLCCSRKHGISFHDISFGTSGRPGNLVLLQFLVGLK QATEDELVAELVVNILKESPDILSRFFKETQYSYTPRIRSAWHDNVKLLK RIYEAQPEISTIFHSSEMIPLPRLLSMAMVISLPPVCNKAFFTQGLNLS- --------------------------------------NSTVQLTTISMI NFILKKANKSIAYLLDKSVLHQSNLYTVEMMEELVQQYRETLGKILPDMT LIISAWQS-----------------------------LSKKE-------- -------------------------KADGEKK------------------ ---------------------------------xxxxxxxxxxx------ --------------------------------------EVIVLKAFILQV ICLYQKVVPHLVTQCKFDFSKLLK-------------------------- -------------------------------GIVFEKGMKEEIPPVLQYQ ILQLALDLPANKFSWFHL-------------------------------- ---------QDVANS----E-SLSGEKSVLYLLLKMFV-SSS-SSHLSST TRKLILKVLRDTGVFEYTFTEFNLWLDQLARIKSNQQDTVIQFLERVLVK LVCNSYDYTDRVAGFVQEAANIQANLSVQEGEAASVPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGSEGEMEEFGPSLSEDLIIQTFPFSVAVPAALEARNK L-----------P----ADK-------G--------VVCEYLSAVLSDLL HCQRDPLPLCLALQQYDKELDS-SQH-PPLHR---SIAELHQYYARWLPQ QCREEL-------------------------------------------- -----------FKS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SESFSKDLAAPSSYS-------------SLIKAA YIQGPGA----------------LLEDSFRQDAEKALAVMSLSEFPVLIK QILLYIKSTVESFG---------T-------------------------- ---------------xxxxxx--ADP------------------------ -----------------------AVxNSR--------------------- -----------------------EGSDL-----------SLELNQSQTIE -------------CNKEQVVVSALGSVFKHPCLEQWFLALELAALPPHSL KPVALKRLCAQLTERILSLLKISAPALDELNHLELISGYMAAIERAALKE L--------AER----GSRPAKTYSKSFQALLSLHGYMDSSNLRELVSRL LLLPQESLFL----------P-STEGPQSELSVYGHVALQILTKCYSASL QNQN--IFLTQ--------------------------------------- ---AHFHGLGALLLSCSSPELDAFLLQALSSKPGSARLIHTDVLLRCL-- ------R----RSRPDSLAVVSLLLQNSSSHRLCFEMWCEE--------P TNMKVLS-ETKVS---LPLINTYLKVAQREDPARPKE------------- -------------------------------------------------- --------------------VQKEVLKAMKQALLSK-------------- ------------------------------------------------FS QSILGNLSEDHGVHL--VEAAASLIKLSADVNDIQALINNLP-------- ----DFLQK------xxxxxxRWNLVDIITEKLADCTEEQEKWRRSVVAA ALKCLIASY-------------------------------CHSKDQ---- --------------TVSPSDQEEGILKRL-QQLL---------xxx---- --xx-----xxxxVSDWNSFVKNGLKYRYCN------------------- ---------------------QHFLNTLSSLLEVMYGSAEQQKELIPLSS LHLMTTSHSQFLPVMLDS-------------------------------- --------------------------------------------KALVSL LLCVVQKCPKVCNINHFIVLLAAYGATLSTSDQKLLMLLRQYERCQVSL- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxx-----------xxxxxxxxxxxxxxxV------------ENLGDL YDPCFLLP----LFSAILQP-----------------------ECVIDCF KFVSCHALGVTVMALSSFDPNMRAAAYHVLACFYQHLEGARFREKRQLLY FMDNLKN------------------------------------------- ---------------------GIPKQNQKLPFVLAVYISKVAQQMLRPED HMYVVLNRFVLSRQSLDLRRVPEFFKLFYGFDL----------------- -----------EHKVEREWILNLLQEGISDGHSYELCSHQNIFQVLLGFS SSPLCSEYIQ-------AQIIKVLCQAAHVPKAVYDLTKSCGLLSWMIQV -------------QTVSAVIDLLHTLWFTSLGQK-------------E-K K--VD----------------x-----------xxxxxxxxxxxxxxVKC LPLPLISEFLCVALAISRHL-R---LGVKAAQLSLFVQTLGSVLVH---- ---------RGSALHVNKQADRLTLHPQPLSSMETLSLLFCWASL----- ------------SHNSTILAQIQALSEKHKIKEL-----MG--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x---xxxxxxxx------------------------ ------------------------KQEESL---------LAGCRVHLSSV FVYWQPVFQ----------------------------------------- -------------------------------------------------L SEPPSAQPGGKLDSRHLACDTAHLLTKW--------------------SL RWLVE--DGYDENRTKDFLTWFEKAVIKQREIVDVLMLDPVVKADLLQLF HNSFEAPGHAS------------------------------xETCQLFTN TMI------------------RLLEMRG-QLPD--L-------------- -----------------HRV----------------------IISA---- ----------CMSD--Q-DQSRH-E--------PG--------------- ------------LFLLSLYIHELWSGSSSADLFLSHVTLV---------- ----TRAQC-KR---------------------------QKGSKS-TxIQ TAI----------------------GAIC-----------SEIIEMK--- --------S----- >ENSXMAP00000024518 -------------------------------------------------- -----MS-------------------KKRPSDAP-VESEAPAKKEKV--- ------------------SEFNGTVFKTMLKNPTTAMK------------ -------------------G------------------------------ -----------------------------------------------LER FISTAKKLPSCDLYDVVEGYIKISMECAEIFKLLEAEKPLETEMMLIFGS LEVILLRTASDLSHFNMVGNVIVKKIASNYMKLLQGSFHSLNHGFVRQCL NLLSAMVSQGAEAAREVFSHVQI-KTLFGLAKRKDKRGKPDVRLAFIQFV LSFLVSGDSAIIGQVLEVKELLPQILNTGLKEDRMSTVNLILSTLKTRIV LNKAISKTQKVRFFTPAVLANIASLYKWNGIVD------------DSDAA GISVVRDLVHRFLVDLCCSRKHGISFHDTSFGTSGRPGNLVLLQFLVGLK QATEDELVAELVVNILKESPDILSRFFKETQYSYTPRIRSAWHDNVKLLK RIYEAQPEISTIFHSSEMIPLPRLLSMVMVISLPPVCNKAFFTQGLNLS- --------------------------------------NSTVQLTTISMM NFILKKANKSIAYLLDKSVLHQSNLYTVEMMEELVQQYRETLGKILPDMT LIISAWQS-----------------------------LSKKE-------- -------------------------KADGEKK------------------ ---------------------------------xxxxxxxxxxx------ --------------------------------------EVIVLKAFILQV ICLYQKVVPHLVTQCKFDFSKLLK-------------------------- -------------------------------GIVFEKGMKEEIPPVLQYQ ILQLALDLPANKFSWFRL-------------------------------- ---------QDVANS----E-SSSGEKSVLYLLLKMFV-SSS-SSHLSST TRKLILKVLRDTGVFEYTFTEFNLWLDQLARIKSNQQDTVIQFLERVLVK LVCNSYDYTDRVAGFVQEAANIQANLSVQEGEAASVPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGSEGEMEEFGPSLSEDLIIQTFPFSVAVPAALEARNK L-----------P----ADK-------G--------VVCEYLSAVLSDLL HCQRDPLPLCLALQQYDKELDS-SQL-PPLHQ---SIAELHQYYARWLPQ QCREEL-------------------------------------------- -----------FKS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SESFSKDLAAPSSYS-------------SLIKAA YIQGPGA----------------LLEDSFRQDAEKALAVMSLSEFPVLIK QILLYIKSTVESFG---------T-------------------------- ---------------xxxxxxxxADP------------------------ -----------------------AVxNSQ--------------------- -----------------------EGSDL-----------SLELNQSQTIE -------------CNKEQVVVSALGSVFKHPCLEQWFLALELAALPPHSL KPVALKRLCAQLTERILSLLKISAPALDELNHLELISGYMAAIERAALKE L--------AER----GSCPAKTYSKSFQALLSLHGYMDSSNLRELVSRL LLLPQESLFL----------P-STEGPQSELSVYGHVALQILTKCYSAPS QNQN--IFLTQ--------------------------------------- ---AHFHGLGALLLSCSSPELDAFLLQALSSKPGSARLIHTDVLQRCL-- ------R----RSRPDSLAVVSLLLQNSSSHRLCFEMWCEE--------P TNMKVLS-ETKVF---LPLINTYLKVAQREDPARPKE------------- -------------------------------------------------- --------------------VQKEVLKAMKQALLSK-------------- ------------------------------------------------FS QSILGNLSEDHGVHL--VEAAASLIKLSADVNDIQALINNLP-------- ----DFLQKAESF-E------RWNLVDIITEKLADCTEEQEKWRRSVVAA ALKCLIASY-------------------------------YHSKDQ---- --------------TVSPSDQEEGILKRL-QQLL---------xxx---- --xx-----xxxxVSDWNSFVKNGLKYRYCN------------------- ---------------------QHFLNTLSSLLEVMYGSAEQQKELIPLSS LHLMTTSHSQFLPVMLDS-------------------------------- --------------------------------------------KALVSL LLCVVEKCPKVCNINHFIVLLAAYGATLSTSDQKLLMLLRQYERCQVSLL KF--x--------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxx-------------xxxxxxxxxxxxxxV------------KNLGDL YDPCFLLP----LFSAILQP-----------------------ECVIDCF KFVSCHALGVTVMALSSFDPNMRAAAYHVLACFYQHLEGARFREKRQLLY FMDNLKN------------------------------------------- ---------------------GIPKQNQKLPFVLAVYISKVAQQMLRPED HMYVVLNRFLLSRQSLDLRRVPEFFKLFYGFDL----------------- -----------EHKVEREWILNLLQEGISDGHSYELCSHQNIFQVLLGFS SSPLCSEYIQ-------AQIIKVLCQAAHVPKAVYDLTKSCGLLSWMIQV -------------QTVSAVIDLLHTLWFTSLGQK-------------E-K K--VD----------------x-----------xxxxxxxxxxxxxxVKC LPLPLISEFLCVALAISRHL-R---LGVKAAQLSLFVQTLGSVLVH---- ---------RGNALHVNKQADRLTLHPQPLSSTETLSLLFCWASL----- ------------SHNSTILAQIQALSEKHKIKEL-----MG--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxx------------------------ ------------------------KQEESL---------LAGCRVHLSSV FVYWQPVFQ----------------------------------------- -------------------------------------------------L SEPPSAQPGGKLDSRHLACDTAHLLTKW--------------------SL RWLVE--DGYDENRTKDFLTWFEKAVIKQREIVDVLMLDPVVKADLLQLF HNSFEAPGHAS------------------------------xETCQLFTN TMI------------------RLLEMRG-QLPD--L-------------- -----------------HRI----------------------IISA---- ----------CMSD--Q-DQSRH-E--------PG--------------- ------------LFLLSLYIHELCSGSSSADLFLSHVTLV---------- ----TRAQC-KR---------------------------QKGSKS-TxIQ TAI----------------------GAIC-----------SEIIEMK--- --------S----- >ENSGAFP00000030712 -------------------------------------------------- -----MS-------------------KKRPSDAP-VESEAPAKREKA--- ------------------PEFNGTVFKTMLKNPTTAMK------------ -------------------G------------------------------ -----------------------------------------------LER FISTAKKLPSSDLYDVVEGYIKISMECAEIFKLLEAEKPLETEMMLIFGS LEVILLRTASDLSHFNMVGNVIVKKIASNYMKLLQGSFHSPNHGFVRQCL NLLSAMVSQGAEAAREVFSHVQI-KTLFGLAKRKDKKGKPDVRLAFIQFV LSFLVSGDSAIIGQVLEVKELLPQILNTGLKEDRMSTVNLILSTLKTRIV LNKAISKTQKVRFFTPAVLANIASLYKWNGIVD------------DSDAA GISVVRDLVHRFLIDLCCSRKHGISFHDTSFGTSGRPGNLVLLQFLAGLK QATEDELVAELVVNILKESPDILSRFFKESQFSYTPRIRSAWHDNVKLLK RIYEAQPEISTIFHSGEMIPLPRLLSMVMVISLPPVCNKAFFTQGLNVS- --------------------------------------HLTVQLTTMSMI NFILNKANKSIEYLLDKSVLHQSNLYTVEMMEELVQQYRETLGKILPDIT LIISTWQS-----------------------------LSKKE-------- -------------------------KADGEKK------------------ ---------------------------------xxxxxxxxxxx------ --------------------------------------EVIVLKAFILQV ICLYQKVVPHLVTQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMKEEIPPVLQYQ ILQLALYLPANKFSWFRL-------------------------------- ---------QDVANS----E-SSSGEKSVLYLLLKMFV-SSS-SSHLSST TRKLILKVLRDTGVFEYTFTEFNLWLDQLARIKSNQQETVIQFLERVLVK LVCNSYDYTDRVAGFVQEAANIQANLSVQEGETASVPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGSEGEMEEFGPSLSEDLIIQTFPFSAAVPAALEARNK L-----------P----ADKxxxxxxx----------------------- ----DPLPLCLALQQYDKELVS-SQL-PPLHQ---SIAELHQYYTRWLPQ QCREEL-------------------------------------------- -----------FIS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SESFSKDLAAPSSYS-------------SLIKAA YIQGPGA----------------LLEDCFRQDAEKALAVMSLSEFPVLIK QILLYIKSTVESFG---------K-------------------------- ---------------xxxxxxxxSDA------------------------ -----------------------VMxNSQ--------------------- -----------------------EGSDL-----------FLELNQSQTVE -------------CNKEQVVVSALGSVFKHPCLEQWFLALELAALPPHSL KPVALKRLCAQLAEQILSLLKISAPALDELNRLELISGYMAAIERAALKE L--------AER----GSHPAKTYSKSFQALLSLHSYMDSSNLRELVSRL LLLPQKSLIC----------P-STEGPQSELSVYGHVALQILTKCYSASS QNQN--IFLTQ--------------------------------------- ---AHFHGLGALLLSCSSPELDAFLLQALSSRPGSAKLIHTDVLLRCL-- ------R----RSRPDSLAVVSLLLQNSSSHRLCFEMWCEE--------P TNMEVLS-ETKVF---LPLINTYLKVAQREDPARPKE------------- -------------------------------------------------- --------------------VQKEVLKPMKKALLSM-------------- ------------------------------------------------FS QSILGNLSEDHGVHL--VEAAASLIKLSADVNDIQALINNLP-------- ----DFLQKPESF-E------RWNLVDIITEKLADRTEEQEKWRRSVVAA ALKCLIASY-------------------------------CHSKDQ---- --------------T----DQEEGILKRL-QQLL---------xxx---- --xx-----xxxxVSDWNSFVKNGLKYRYCN------------------- ---------------------QHFLNTLSSLLEVMYGSAEHQKELIPLSS LHLMTTSHSQFLPVMLDS-------------------------------- --------------------------------------------KALVSL LLCLVQKCPKVCNINHFIVLLAAYGATLSTSDQKLLMLLRQYERHQVSLL KF--Q---------------------------SLLWGPAAIEHHKTRKTL GASLWKQPSSDEVLALLKADKMLHTVLKFPQERRIIPQ------------ -------------------------------xxxxxxxxxxxxxx----- ------------------------------------------------DL YDPCFLLP----LFSAILRP-----------------------ECVIDCF KFVSCNALGVTVMALSSFDPNMRAAAYHVLACFYQHLEGARFREKRQLLY LMDNLKN------------------------------------------- ---------------------GIPKLNQKLPFVLAVYISKVAQQMLRPEN HMYVVLNRFLLSRQSLDLRRVPEFFKLFYGFDQ----------------- -----------EHKVEREWILNLLREGISDGHSYELCSHQHIFQVLLGFS SSPLCSEYIQ-------AQIIKVLCQAARVPKAVYDLTKNCGLLSWMIQV VDK-KFVxxxPTTTTISVVIDLLHTLWFTSLGQK-------------E-K K--VD----------------x-----------xxxxxxxxxxxxxxVKC LPLPLISEFLCVALAISRHL-R---LGVKAAQLSLFVQTLGSVLVH---- ---------RGSVLHVNKQADRLTLHPQPLSSTETLSLLFCWASL----- ------------SHNSTILAQIQALSEKHKIKEL-----MGxxxxxxxxx x-----------------------xxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------x---------xxx------------------------ ------------------------KQEESL---------LAGCRVHLSSV FVYWQPVFQ----------------------------------------- -------------------------------------------------L SEPPSAQPGGKLDSRHLACDTAHLLTKC--------------------SL RWMVE--DGYDENRTKEFLTWFEKAVIKHREIVDVLILDPVVKADLLQLF HNSFEAPGHAS------------------------------xETCQLFTN TMI------------------RLLEMRG-QLPD--L-------------- -----------------HRV----------------------IISA---- ----------CMSD--Q-DQSRH-E--------TG--------------- ------------LFLLSLYIHELWSGSSSADLFLSHVTLV---------- ----TRAQC-KR---------------------------QKGSKS-TxIQ TAI----------------------GAICxxxxxxxxxxx---------- -------------- >ENSPMEP00000005284 -------------------------------------------------- -----MS-------------------KKRPSDAP-VESEAPAKKEKA--- ------------------PEFNGTVFKTMLKNPTTAMK------------ -------------------G------------------------------ -----------------------------------------------LER FISTAKKLPSSDLYDVVEGYIKISMECAEIFKLLEAEKPLETEMMLIFGS LEVILLRTASDLSHFNMVGNVIVKKIASNYMKLLQGSFHSLNHGFVRQCL NLLSAMVSQGAEAARDIFSHVHI-KTLFGLAKRKDKRGKPDVRLAFIQFV LSFLVSGDSAIIGQVLEVKELLPHILNTGLKEDRMSTVNLILSTLKTRVV LNKAISKTQKVRFFTPAVLANIASLYKWNGIVDAAADYD--xMAEDSDAA GISVVRDLVHSFLVDLCCSRKHGISFHDTSFGTAGRPGNLVLLQFLVGLK QATEDELVAELVVNILKESPDILSRFFKETQYSYTPRIRSAWQDNVRLLK RIYEAQPEISTIFHSTEMIPLPRLLSMVMVISLPPVCNKAFFTQGLSLS- --------------------------------------Nx-VQLTTMSMI NFILKKANKNIEYLLDKSQLHHSNLYTVEMMEELVQQYRETLGKILPDMT LIISTWQS-----------------------------LSKKE-------- -------------------------KADGEKK------------------ ---------------------------------xxxxxxxxxxx------ -----------------------xVxx-------AEKAEVIVLKAFILQV ISLYQKVVPHLVAQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMKEEIPPVLQYQ ILQLALDLPANKFSWFRL-------------------------------- ---------QDVANS----E-SSSGEKSVLYLLLKMFV-SSS-RSHLSST TRKLILKVLRDTGVFEYTFTEFHLWLDQLARIKPNQQETVIQFLERVLVK LVCNSCDYTDRVAGFVQEAANIQANLSVQEGEAASVPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGSEGEMEEFGPSLSEDLIIQTFPFSAAVPAALEARNK L-----------P----ADK-------G--------IVCEYLSAVLSDVL HCQRDPLPLCLALQQYDKELVS-SQL-PPLHQ---SIAELHQYYSRWLPQ QCREEL-------------------------------------------- -----------FKS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SEGFSKDLAAPSSYS-------------SLIKAA YIQGPGA----------------LLEDSFRRDAEKALAVMSLSEFPVLIK QILLYIKSTVESFG---------TFSKEPGDAFLR---------TLMEML QDVVIKLQSFEETTS--------TDP------------------------ -----------------------AVxNSQ--------------------- -----------------------EGSDL-----------FLELNEPQTIE -------------CNKEQVVVSALGSVFKHPCLEQWFLALELAALPPHSL KPVALKRLCAQLTERILSLLKISAPALDKLNHLELISGYMAAVERAALKE L--------VER----GSRPAKTHSKSFQALLSLHGYMDSSNLRELVSRL LLLPQESLIC----------P-SAEGPHSELSVYGHVALQILTECYSASS QNQN--TFLTQ--------------------------------------- ---AHLHGLGALLLSCSSPELDAFLLQALSSKPDSARLINTDVLLRCL-- ------R----RSRPDSLAVVSLLLQNSSSHRLRFEMWCEE--------P ANMEMLS-ETKAF---LPLINTYLKVAQREDPARPNE------------- -------------------------------------------------- --------------------VQKEVLKAMKQALLSK-------------- ------------------------------------------------FS QRILGNLSEDHGVHL--VEAAASLIKLSADVNDIRGLINDLP-------- ----DFLQKPERF-E------RWNLVDIITEKLADSTEEQEKWRRSVVAA ALKCLIASY-------------------------------CRSKDQ---- --------------TASPSDQEEGILKRL-QQLLK----SAEDVG----- -------------VSDWNSFVKNGLKYRYCN------------------- ---------------------QHFLNTLSSLLEVMHGSAEHQKELIPLSS LHLMTTSHSQFLSVMLDSSEES-NKYQVK--------------------- --------------------------------------------EALVSL LLCLVEKCPKVCNINHFIVLLAAYGATLSTSDQKLLMLLRQYERHQVSLL KF--Q---------------------------SLLWGSAAVEHHKTRKTL GASLWKQPSSDDVLALLKADKMVQTVLKFPQERRIIPQ------------ ---------------------DGTEQLYSNDA------------------ -------------------------------V------------KNLGDL YDPCFLLP----LFSAILRP-----------------------ECVIDCC KFVSCHALGVTVMALSSFDPNVRAAAYHVLACFYQHLEGARFREKRQLLY LMDSLKN------------------------------------------- ---------------------GIPKQNQKLPFVLAVYISKVAQQMLRPED HMYVALNRFLLSHQSLDLRRVPEFFKLFYGFDL----------------- -----------EHKVEREWILNLLQEGISDGHSYNLCSHQSIFQVLLGFS SSPLCNEYIQ-------VQIIKVLCQAAHVPKAVYDLTKSCGLLSWMIQV VDK-KTL----TQQTVSAVIDLLHTLWFTSLGQK-------------E-K K--VG----------------x-----------xxxxxxxxxxxxxxVKC LPLPLISEFLCVALAISRHL-R---LGVKAAQLSLFVQTLGSVLVH---- ---------RGSALHVNKQADRLTLHPQPLSSTETLSLLFCWASL----- ------------SHNSIVLAQIQALSEKHKIKEL-----MG--------- ----------------------------LGKHRVRSK------------- ------G------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxx------------------------ ------------------------EQEESL---------LTGCRVHLSSV FVYWQPVLQ----------------------------------------- -------------------------------------------------L SEPPSAQPGGKLDARQLACDTTHLLTKW--------------------SL RWLVE--DGYDENRTKDFLTWLEKAVIKHREIVDVLMLDPGVKADLLQLF HDTFEAPSHAS------------------------------xETCQFFTN IMI------------------RLLEMRG-QLPE--L-------------- -----------------HRV----------------------IVSA---- ----------CMSD--Q-DPSRH-E--------PG--------------- ------------LFLLSLYIHELWSGSSSADLFLSHVTLV---------- ----TRAQR-KR---------------------------QKGFKS-TxIQ TAI----------------------GAIC-----------SEIIEMK--- --------S----- >ENSPREP00000019874 -------------------------------------------------- -----MS-------------------KKRPSDAS-VESEAPTKKEKA--- ------------------PEFNGTVFKTMLKNPTTAMK------------ -------------------G------------------------------ -----------------------------------------------LER FISTAKKLPSSDLYDVVEGYIKISMECAEIFKLLETEKPLETEMMLIFGS LEVILLRTASDLSYFNMVGSVIVKKIASNYMKLLQGSFHSLNHGFVRQCL NLLSAMVSQGAEAARDVFSHVHI-KTLFGLAKRKDKRGKPDVRLAFIQFV LSFLVSGDSAIIGQVLDVKELLPHILNTGLKEDRMSTVNLILSTLKTRIV LNKAISKTQKVRFFTPAVLANIASLYKWNGIVDAAADDDNxxMAEDSDAA GILVVRDLVHSFLFDLCCSRKHGISFHDTSFGTAGRPGNLVLLQFLVGLK QATEDELVAELVVNILKESPDILSRFFKETQYSYTPRIRSAWQDNVKLLK RIYEAQPEISTIFHSSEMIPLPRLLSMVMVISLPPVCNKAFFTQGLNLS- --------------------------------------Nx-VQLTTMSMI NFILKKANKNIEYLLDKSLL-xSNLYTVEMMEELVQQYRETLGKILPDMT LIISTWQS-----------------------------LSKKE-------- -------------------------KADGEKK------------------ ---------------------------------xxxxxxxxxxx------ -----------------------xVxx-------AEKAEVIVLKAFILQV ISLYQKVVPHLVTQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMKEEIPPVLQYQ ILQLALDLPANKFSWFRL-------------------------------- ---------QDVANS----E-SSSGEKSVLYLLLKMFV-SNS-SSHLSST TRKLILKVLRDTGVFEYTFTEFNLWLDQLARIKPNQQETVIQFMERVLVK LVCNSCDYTDRVAGFVQEAANIQANLSVQEGEAASVPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGSEGEMEEFGPSLSEDLVIQTFPFSAAVPAALEARNK L-----------P----ADK-------G--------VVCEYLSAVLSDVL HCQRDPLPLCLALQQYDKELVS-SQL-PPLHQ---SIAELHQYYSRWLPQ QCREEL-------------------------------------------- -----------FKS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SESFSKDLAAPSSYS-------------SLIKAA YIQGPGA----------------LLEDSFRRDAEKALAVMSLSEFPVLIK QILLYIKSTVESFG---------TFSKEPGDAFLR---------TLMEML QDVVTKLQSFEETTS--------ADP------------------------ -----------------------AVxNSQ--------------------- -----------------------EGSDL-----------FLELNEPQSIE -------------CNKEQVVVSALGSVFKHPCLEQWFLALELAALPSHSL KPVALKRLCAQLSEQILSLLKISAPALDELNHLELISGYMLAVERAALKE L--------VER----GSRPAKTHSKSFQALLSLHSYMDSSNLRELVSRL LLLPQESLIC----------P-SAEGPQSELSVYGHVALRILTECYSASS QNQN--TFLTQ--------------------------------------- ---AHLHGLGALLLSCSSPELDAFLLQALSSKPGSARLIHTDVLLRCL-- ------R----RSRPDSLAVVSLLLQNSSSHRLCFEMWCEE--------P ANMEMLS-ETKAF---IPLINAYLKVAQREDPARPKE------------- -------------------------------------------------- --------------------VQKEVLKAMKQALLSQ-------------- ------------------------------------------------FS QSILGNPSEDHGVHL--VEAAASLIKLSADVNDIRGLINDLP-------- ----DFLQKPERF-E------RWTLVDILTEKLADGTEEQEKWRRSVVAA ALKCLIASY-------------------------------CSSKDQ---- --------------TASPSDQEEGILKRL-QQLLK----SAEDVS----- -------------VSDWNSFVKNGLKYRYCN------------------- ---------------------EHFLNTLSSLLEVMYGSAE-QKELIPLSS LHMMTTSHSQFLPLMLDSSEES-NKYQVK--------------------- --------------------------------------------EALVSL LLCLVEKCPKVCNINHFIVLLAAYGATLSTSDQKLLMLLRQYEKQQVSLL KF--Q---------------------------SLLWGPAAVEHHKTRKTL GASLWKQPSSDDVLALLKADKMVQTVLKFPQERRIIPQ------------ ---------------------DGTEQLYSNDK------------------ -------------------------------V------------KNLGDL YDPCFLLP----LFSAILRP-----------------------ECVIDCC KFVSCHALGVTVMALSSFDPNVRAAAYHVLACFYQHLEGARFREKTQLLY LMDSLKN------------------------------------------- ---------------------GIPKQNQKLPFVLGVYISKVAQQMLRPED HMYVVLNRFLLSHQNLDLRRVPEFFKLFYGFDV----------------- -----------EHKVEREWILNLLQEGISDGHSYELCSHQSIFQVLLGFS SSPLCSEYIQ-------AQIIKVLCQAAHVPKAVYNLTKSCGLLSWMIQV LDK-KTL----TQQTVSAVIDLLHTLWFTSLGQK-------------E-K K--VG----------------x-----------xxxxxxxxxxxxxxVKC LPLALISEFLCVALAITKHL-R---LGVKAAQLSLFVQTLGSVLVH---- ---------RGSALHVNKQADRLTLHPQPLSSTETLSLLFCWASL----- ------------SRNSVILAQIQALSEKHKIKEL-----MG--------- ----------------------------LGKHKVRSK------------- ------G------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxx------------------------ ------------------------EQEKSL---------LTGCRVHLRSV FVYWQPVLQ----------------------------------------- -------------------------------------------------L SEPPSAQPGGKLDARHLACDTTHLLTKW--------------------FL RWLVE--DGYDENRTKDFLTWLEKAVIKHREIADVLMLDPGVKADLLQLF HDTFEAPGHAS------------------------------xETCQLFTN IMI------------------RLLEMRG-QLPE--L-------------- -----------------HRV----------------------IVSA---- ----------CMSD--Q-DQSRH-E--------PG--------------- ------------LFLLSLYIHELWSGSSSADLFLSHVTLV---------- ----TRTQH-KR---------------------------QKASKS-TxIQ TAI----------------------GAIC-----------SEIIEMK--- --------S----- >ENSFHEP00000025517 -------------------------------------------------- -----MG-------------------KKRPGDAS-AEPESPAKKEKA--- ------------------PEFNGTVFKSMLKNPTTAMK------------ -------------------Gxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------MMLVFGS LEAILLRTASDLSHFNAVGNVVVKKLLSSHMKLLQGSFYSANHGFVRQCL NLLSAMVSQGVEAAREVFGHVQT-KTLSGLAKRRDKRGKPDVRLAFIQFA LSFLVSGDSAIIGHVLEVKELLPHILNTGLKEDRLSTVNLILSTLKTRVV LNKAITKTQKVRFFTPAVLSNVASLYKWSGIADAAA---------DCDAA GTSVVRELVHGFLVDLCCSRKHGINFHDPSFGTAGRPGNLVLLQFLVGLK QATEDELVAELVVNALKASPDILSRFFKETQYSYAPRLRSAWQDNVKLLK RIYEAQPDISTIFQTGEMIPLPRLLSMIMVISLPPVCNKAFFRQGLSVSx -------------------------------------xxx-xILTTVSAI NFILKKAAKNVEYLSDKSAWLKSDLYAADAMEELVQQYREGAG------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------PVVVLKAFILQV ICLYQKVVPHLVTQSKFDFSKLLK-------------------------- -------------------------------GIVSEKGLKEEIPPVLQYQ VLQLALDIPANKFSWFRL-------------------------------- ---------Q-VSEA----S-PSSGEKSVLYLLLKMFL--xx-SSHLSSA TRKLVLKVLRDTGVFEYTFTELDLWLDQLARIKPDQQEAVIHFLERVLVK LVSNSYDYTDRVAGFVQDAANLQANLSVQEGEAASVPVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGSDGEMEEFGPTLSEDLIVQTFPFSAVVPAALEARNN L-----------P----ADK-------G--------VVCEYLSAVLSDVL HCQRDPLPLCLALQQYDKELAS-SQP-APFHQ---SIANLHRYYSRWLPQ QCREEL---------------------------------------xx--- -xxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------S-------------ALIKAA YVQGPGA----------------LLEDTFRQNAEKALAFMSLAEFPALIK QILLYIKSTVESFG---------K---------xxxxxxxxx-xTLMEML QDVVTKLQSFEETIN--------AEP------------------------ -----------------------AAxKPQ--------------------- -----------------------EGSDL-----------FLELDQSSSTE -------------RNKEQIVVSALGSIFKHPCLEQWFLALELAALPPHSL KPVPLKRLCAQLTDGVLSLLKISAPVLDELQCLGLISSYMGAIERTALKE L--------AER----GSKPPKTYSRSLQALISLHGYMDSTDLRELLSRL LLLPHESLVC----------S-AGEGTQSELSVYGRVALQILTKYYSTSS ENQS--AFLTP--------------------------------------- ---AHLHGLGTLLLSCSSPELEAFLLQALSSRPGSARLIHTDVLLHCL-- ------R----RPLPDSLAVASLLLQNCSSHRLCFEVWCEE--------P ANMEKVS-EGKAF---LPLITTYLQLAQGEDPARPKD------------- -------------------------------------------------- --------------------VQQAVLKTMKEAFLPR-------------- ------------------------------------------------FS QSILGTLAEDSVVHL--VEAAAGLIKASADVNDIQDLIKNLP-------- ----EALQKAEGF-E------RWRLVDVITEKLADCAEELEEWRRCVVAA ALKCLTASY-------------------------------CRSKDQ---- --------------AASPSDQERGVLKRL-QQLL---------xxxxxxx xxx-----------SDWNSFVKNGLKYRYGN------------------- ---------------------QHFLNTLSSLLEVMYGSTDSQKDLIPLST LHMMSTSHSQFLPTMLDASEEP-DACQAK--------------------- --------------------------------------------EALVSL LLCLVKKCPKVCNVNHFVVLLAAYGATLSTADQKLLLLLWEYERNQVSLL RF--Q---------------------------SFLWGPAAVEHHKTRKTL GASLWKQPSSDDVLALLKADRMLQTILKFPQGRRIIPQ------------ -------------------------------------------------- -------------------------------xxxxxxxxxxxxxKNLGDL YDPCFLLP----LFSAILQP-----------------------ECVVDCF KFVSCHALGVTVMALSSADPNVRAAAYHVLVCFYQHLEGARFREKRQLLY LMDIVKN------------------------------------------- ---------------------GVPKQNHRLPFILAIYISKVAQQMLRPED HMYVVLNRFLLSHQSLDLRRVPEFFKLFYGFDM----------------- -----------EHKVEREWILNLLEEGVSDGHSYELCNNQSIFQVLLGFS SSPLCSEYVQ-------VQIIKVLCQAARVLKAVYNLTKNCGLLSWMIQV --------------TVCALIELLHTLWFTNVLQR-------------E-K K--VDRRS-AAPSAEEKPPRSx--------------------------KC PPLPLIGEFLCVASAICRHL-R---LGVKAAQLSLFAQTLHSVLEH---- ---------RATALSVHKQTERLALRPQPLSSAETLSLLLCWASL----- ------------SRNAAVL---------------------G--------- ----------------------------IWKHKVRSK------------- ------x------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxx------------------------ ------------------------KEEEGL---------LAGCKVHLCGI FVHWEPVFR----------------------------------------- -------------------------------------------------L SEPQSAQPRDKLDAGQLACDTAHLLTKW--------------------SL RWLVE--DAHDEARTKEFLSWFERAAVKHREVVDVLMLDPGSKADLLQLF HHTFEARGHSSASA--------------------------RMETCQLFTN IMI------------------RLLEMQG-QLQE--R-------------- -----------------HRA----------------------VIAA---- ----------CMPD--Q-DQSRH-E--------PG--------------- ------------LFLLSLYIHELWSGAASPDLFLSHVSLV---------- ----TGAKC-KR---------------------------QKGSKS-PxSL TAI----------------------RAIC-----------NDIIRIK--- --------Sxxxxx >ENSORLP00000004262 -------------------------------------------------- -----MA-------------------EKRRAGAS-AKSAVPVKKGKS--- ------------------PEFNGAEFKAMLKNPTTAMK------------ -------------------G------------------------------ -----------------------------------------------LET FVSIARKLPCLDLYDVVEGYLKISMECAEIFQLLEGEKHAENETMLVFES LEVILLRTASDLSHFNMVGNGIVRKIVSSHMKLLQGSLHSANHRLVRHCL NLLSTMVSQGVEAAREVFSHIHI-KALSGLEKRRDKLGRPDVRLAFIQFA LSFLVSGDGAIIGQILEVKELLPHILSSGVREDRMSTVNLILSTLMTRVV LNKAISKTQKVRFFTPVVLSNIASLYRWKGIPDATTDDCD--xx--QDSS GVSVVRKLVHRFLLELCCSRKHGIIFHDAHFGTAGGGGNIVLLQFLVGLK QATEDELVAELVVNILKNSPDILSRYFKETQYSYTPRLKSAWQDNVNLLK KIYEAQPDISTVFQFGEMIPLSRLISMIMVISLPPVCNKTFFTQGLSLA- --------------------------------------NNKVQLTTVSVI NFVLKRTSKNIEYLLDKAVWERSDVYSAEMMEQLVQQYREALGKILPDMT TIISTWQS-----------------------------LSKKE-------- -------------------------KTEGDDNKSTGDGSA---------- -------------------------------------xxxxxxx------ -----------------------xLPx-------AETTEVVLLKALILQV ICLYQRVMPHLVLQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMKEEVPPVLQYQ ILQLALDLPASKFSWFHI-------------------------------- ---------QEVADA----D---SAEKSVLYLLLKMFI-SSS-RSHLRSS TQKLVVKVLQDTGVFEHTWMELELWLNQLDRVKPNQQETVIQFLERVFVK LVCNSYEYTDKVASLVQEAAYLQANLSSQEGDASSLPVSHI--------- ---------D---------------------------------------- --DVLDMLDIIMEGSEGEMEEFGPTLSEELIIQTFPFSAVVPAALEARNK L-----------K----SDK-------G--------EVCEYLSAVLSDVL HCQRDPLPLCLALLHYDKELVS-SGTPASSHL---SVLHLHQYYSSWLPQ QSREEL-------------------------------------------- -----------FKS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SACLSNEELTSNSFS-------------TLMKAA YMQGPST----------------LTTNTFRKNIEAALDSMLLAEFPIAIK QVLLYVKSTVENFG---------TFSKETGTALLK---------TLMGIL QDMMTKLQSFAETQN--------SEA------------------------ ----------------------xPxxEEQ--------------------- -----------------------DASDL-----------FLDVNQSSMVE -------------TNKNQILVAALGSIFKHPCLEQWFLALELSALPPHSL KPVRLKHLCALMTDGTLTLLQIGAPVLRDLCHAELLSGCMSAIKRAVLKE L--------SEK----RPHPPKSHSRTFQALLSLHSYMDSSNLREVALSL LLQPQDTLIC----------V-SSETAGSDLSIYGHAALQILTTRTSMTS EDDC--AFLTP--------------------------------------- ---AHLQGLSTLLLSCSSPEPAALMLQTLSREPSFAKLMHTDVLSRCL-- ------Q----EPLPDFLAINSLLLQNCSSHRLCFELWCLE--------P ANMAKLSRETEAF---LPLINTYLEVASREDPARPKA------------- -------------------------------------------------- --------------------VQKEVLKALKQALLDK-------------- ------------------------------------------------LP QGILGNLTDDR--EI--AATVANLIKLSTDIKDFWDLISYLP-------- ----SVLPNADSF-Q------RWKLVDVITDKLVDYPEELEKWRKSVSIA ALKCLTASF-------------------------------CGSKDP---- --------------SAAATEQEHSVLQTL-KQLLA----FAEDIP----- -------------ASEWNSFVKSGLKYRYRD------------------- ---------------------SCFLNTLSSLLAVMYGEEEVQKDLLPLST LHLMISSHSQFLPTMLGCGEEP-DKSPEK--------------------- --------------------------------------------EALVSL LLCVVKKCPKVCNISHFVVLLGAYSATLSTSDQKLLLLLQEYERNQASLL KF--Q---------------------------SFLWGPAAVEHHKTRKSL GASLWKQASSDELLALLKTDRMLQTISQFPQQRRIILQ------------ ---------------------DEVEQLYSNKA------------------ -------------------------------V------------KDLSNL YDPCFLLP----LFSVILRP-----------------------ECVIDCH KFISSHALGFTIMALSSSDPKVRAAAYHVLGSFYQHLEGARFREKRQMLY LMDIVKN------------------------------------------- ---------------------GIQRQNQRVPFVLTSYIAKVAQQMLRPED HMYVVLNKFLLSQQSLDLKRVPEFFKLFYSFDL----------------- -----------EHKMEREWILNVLGEGINDDHCFKLCNQQGIFQSLLGFG SSPLCDETFQ-------VQIIRVLCKAARVTKGAYNLTKSSGILSWMIHF IEK-KNL----TQQLLCSVVDLLCVLWFTNLGEK-------------E-K K--ADGAG-ASSPSGEKPQGA--------------------------VKY LPLPFINEFLCAASAVCRHL-R---LGVKAAQLSMFVQMLSTALMH---- ---------RGTALSVNKQAEWLTLRPQPLSSAESLTLLHCWATL----- ------------SHNAALLSQIQELSNRHKVAEL-----MG--------- ----------------------------MGKDKFRGK------------- -------------------------------------------------x xx------------------------------------------------ ---------------------------xxTRGENSAEDDE---------- ----------------------GDKQ-ESL---------LRECKPSLCSI FIHWEPELH----------------------------------------- -------------------------------------------------S SEAQSAVSKDGLEPRLLACDTAHLLTRW--------------------SL KWLLE--DAYEDDKAKQFLLWFEKAVQRHRKMVKAVMLDPGLKADLLCLY HRSFET---------xxxxxx----------------------TLKRFTH IMI------------------RMLETEG-QLTD--Y-------------- -----------------HRA----------------------VMSA---- ----------CIQEPSH--ESRx-E--------AG--------------- ------------LFLLSMFIHELWSGAASAELFLSYVGLV---------- ----TKTKN-QK---------------------------PKGSKS-SxTQ TAV----------------------RAIC-----------EEIVAIK--- --------I----- >ENSORLP00020029624 -------------------------------------------------- -----MA-------------------EKRRAGAS-ANSAVPVKKGKS--- ------------------PEFNGAEFKAMLKNPTTAVK------------ -------------------G------------------------------ -----------------------------------------------LET FVSIARKLPCLDLYDVVEGYLKISMECAEIFQLLEGEKHAENETMLVFES LEVILLRTASDLSHFNMVGNGIVRKIVSSHMKLLQGSLHSANHRLVRHCL NLLSAMVSQGVEAAREVFSHIHI-KALSGLEKRRDKLGRPDVRLAFIQFA LSFLVSGEGAIIGQILEVKELLPHILSSGLREDRMSTVNLILSTLMTRVV LNKAISKTQKVRFFTPVVLSNIASLYRWKGIPDATTDDGD--xx--QDSS GVSVVRKLVHRFLLELCCSRKHGIIFHDAHFGTAGGGGNIVLLQFLVGLK QATEDELVAELVVNILKNSPDILSRYFKETQYSYTPRLKSAWQDNVNLLK KIYEAQPDISTVFQSGEMIPLSRLISMIMVISLPPVCNKTFFTQGLSLA- --------------------------------------NNKVQLTTVSVI NFVLKRTSKNIEYLLDKTVWERSDVYSAEMMEQLVQQYREALGKILPDMT TIISTWQS-----------------------------LSKKE-------- -------------------------KAEGDDNKSTGDGSA---------- -------------------------------------xxxxxxx------ -----------------------xLPx-------AETTEVVLLKALILQV ICLYQRVMPHLVLQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMKEEVPPVLQYQ ILQLALDLPASKFSWFHI-------------------------------- ---------QEFADA----D---SAEKSVLYLLLKMFI-SSS-RSHLRSS TQKLVVKVLQDTGVFEHTWMELELWLNQLDRVKPNQQETVIQFLERVFVK LVCNSYEYTDKVASLVQEAAYLQANLSSQEGDASSLPVSHI--------- ---------D---------------------------------------- --DVLDMLDIIMEGSEGEMEEFGPTLSEELIIQTFPFSAVVPAALEARNK L-----------K----SDK-------G--------EVCEYLSAVLSDVL HCQRDPLPLCLALLHYDKELVS-SGPPASSHP---SVLHLHQYYSSWLPQ QSREEL-------------------------------------------- -----------FKS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SACLSNEELTSNSFS-------------TLMKAA YMQGPST----------------LTTNTFRKNIEAALDSMLLAEFPIAIK QVLLYVKSTVENFG---------TFSKETGKALLK---------TLMGIL QDMMTKLQSFAETQN--------SEA------------------------ ----------------------xPxxEEQ--------------------- -----------------------DTSDL-----------FLDVNQSSMVE -------------TNKNQILVAALGSIFKYPCLEQWFLALELSALPLHSL KPVRLKHLCALMTDGTLTLLQIGAPVLRDLCHPELLSGCMSAIKRAVLKE L--------SEK----RSHPPKSHSRTFQALLSLHSYMDSSHLREVALSL LLQPKDTLIC----------V-GSETAGSDLSIYGHAALQILITRTSMTL EDDC--AFLTP--------------------------------------- ---AHLQGLSTLLLSCSSPEPAALMLQTLTREPSFAKLMHTDVLSRCL-- ------Q----EPLPDFLAINSLLLQNCSSHRLCFELWCLE--------P ANMAKLSRETEAFxxLLPLINTYLEVASREDPARPKD------------- -------------------------------------------------- --------------------VQKEVLKALKQALLDK-------------- ------------------------------------------------LL QGILGNLTDDR--EI--AATVAKLIELSTDIKDFWDLISNLP-------- ----SVLPNVDSF-Q------RWKLVDVITDKLVDYPEELEKWRKSVSIA ALKCLTASF-------------------------------CGSKDP---- --------------SAAATEQEHSVLQTL-KQLLA----FAEDIP----- -------------ASEWNSFVKSGLKYRYRD------------------- ---------------------SCFLNTLSSLLAVVYGEEEVQKDLLPLST LHLMISSHSQFLPTMLGCGEEP-DKSHEK--------------------- --------------------------------------------EALVSL LLCVVKKCPKVCNISHFVVLLGAYSATLSTSDQKLLLLLQEYERNQASLL KF--Q---------------------------SFLWGPAAVEHHKTRKSL GASLWKQASSDELLALLKTDRMLQTISQFPQQRRIILQ------------ ---------------------DEVEQLYSNKA------------------ -------------------------------V------------KDLSNL YDPCFLLP----LFSVILRP-----------------------ECVIDCH KFISSHALGFTIMALSSSDPKVRAAAYHVLGSFYQHLEGARFREKRQMLY LMDIVKN------------------------------------------- ---------------------GIQRQNQRVPFVLTSYIAKVAQQMLRPED HMYVVLNKFLLSQQSLDLKRVPEFFKLFYSFDL----------------- -----------EHKLEREWILNVLGEGINDDHCFELCNQQGIFQSLLGFG SSPLCDETFQ-------VQIIRVLCKAARVTKGAYNLTKSSGILSWMIHF IEK-KNL----TQQLLCSVVDLLCVLWFTNLGEK-------------E-K K--ADGAG-ASSPAGEKSQGA--------------------------VKY LPLPFINEFLCAASAVCRHL-R---LGVKAAQLSMFVQMLSTALMH---- ---------RGTALSVNKQAEWLTLSPQPLSSAESLTLLHCWATL----- ------------SHNAALLRQIQELSNRHKVAEL-----MG--------- ----------------------------MGKDKFRGK------------- -------------------------------------------------x xx------------------------------------------------ ---------------------------xxTRGENSAEDDE---------- ----------------------ADKQ-ESL---------LRECKPSLCSI FIHWEPELH----------------------------------------- -------------------------------------------------S SEAQSAVSKDRLEPRLLACDTAHLLTRW--------------------SL KWLLE--DTYEDDKAKQFLLWFEKAVQRHRKMVKAVMLDPGLKADLLCLY HRSFET---------xxxxxx----------------------TLKRFTH IMI------------------RMLEKEG-QLTD--Y-------------- -----------------HRA----------------------VMSA---- ----------CIQEPSH--ESRx-E--------AG--------------- ------------LFLLSMFIHELWSGAASAELFLSYVGLV---------- ----TKTKN-QK---------------------------PKGSKS-SxTQ TAV----------------------RAIC-----------EEIVAIK--- --------I----- >ENSORLP00015017375 -------------------------------------------------- -----MA-------------------EKRRAGAS-AKSAVPVKKGKS--- ------------------PEFNGAEFKAMLKNPTTAVK------------ -------------------G------------------------------ -----------------------------------------------LET FVSIARKLPCLDLYDVVEGYLKISMECAEIFQLLEGEKHAENETMLVFES LEVILLRTASDLSHFNMVGNGIVRKIVSSHMKLLQGSLHSANHRLVRHCL NLLSTMVSQGVEAAREVFSHIHI-KALSGLEKRRDKLGRPDVRLAFTQFA LSFLVSGDGAIIGQILEVKELLPHILSSGLREDRMSTVNMILSTLMTRVV LNKAISKTQKVRFFTPVVLSNIASLYRWKGIPDATTDDGx--x----NSS GVSVVRKLVHRFLLELCCSRKQGIIFHDAHFGTAGGGGNIVLLQFLVGLK QATEDELVAELVVNILKNSPDILSRYFKETQYSYTPRLKSAWQDNVNLLK KIYEAQPDISTVFQSGEMIPLSRLISMIMVISLPPVCNKTFFTQGLS--- -----------------------------------------VQLTTVSVI NFVLKRTSKNIEYLLDKTVWERSDVYSAEMMEQLVQQYREALGKILPDMT TIISTWQS-----------------------------LSKKE-------- -------------------------KPEGNDNKSTSDx------------ -------------------------------------------------- ---------------------------------------IVLLKALILQV ICLYQRVMPHLVLQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMKEEVPPVLQYQ MLQLALDLPASKFSWFHIxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxx---------------------------------------- -------VLQDTGVFEHTWMELELWLNQLDRVKPNQQETVIQFLERVFVK LVCNSYEYTDKVASLVQEAAYLQANLNSQEGDASSLPVSHI--------- ---------D---------------------------------------- --DVLDMLDIIMEGSEGEMEEFGPTLSEELIIQTFPFSAVVPAALEARNK L-----------K----SDK-------G--------EVCEYLSAVLSDVL HCQRDPLPLCLALLHYDKELVS-SGPPASSHP---SVLHLHQYYSSWLPQ QSREEL---------------------------------------xxxxx xx---------x-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------T----------------LTTNTFRKNIEAALVSMLLAEFPIAIK QVLLYIKSTVENFG---------TLSKETGTALLK---------TLMGIL QDMMTKLQSFAETQN--------SEA------------------------ ----------------------xPxxEEQ--------------------- -----------------------DASDL-----------FLDVNQSSMVE -------------TNKKQILVAALGSIFKHPCLEQWFLALELSALPPHSL KPVRLKHLCALMTDGTLTLLQTGAPVLRDLCHAELLSGCMSAIKRAVLKE L--------SEK----RSHPPKSHSRTFQGLLSLHSYMDSSNLREVALSL LLQPQDTLIC----------V-SSETAGSDLSIYGHAALQILTTRTSMTS EDDC--AFLTP--------------------------------------- ---AHLQGLSTLLLSCSSPEPAALMLQTLSREPSFAKLMHTDVLSRCL-- ------Q----EPLPDFLAINSLLLQNCSSHRLCFELWCLE--------P ANMEKLSRETEAF---LPLINTYLEVASREDPARPKD------------- -------------------------------------------------- --------------------VQKEVLKALKQALLDK-------------- ------------------------------------------------LP QGILGNLTDDR--EI--AATVANLIKLSTDIKDFWDLISNLP-------- ----SVLPNVDSF-Q------RWKLVDVITDKLVDYPEELEKWRKSVSIA ALKCLTASF-------------------------------CGSKDPxxxx xxxxxxxxxxxxxx--------------------x----xAEDIP----- -------------ASEWNSFVKSGLKYRYRD------------------- ---------------------SCFLNTLSSLLAVVYGVEEVQKDLLPLST LHLMISSHSQFLPTMLGCGEEP-DTSHEK--------------------- --------------------------------------------EALISL LLCVVKKCPKVCNISHFVVLLGAYSATLSTSDQKLLLLLQEYERNQASLL KF--Q---------------------------SFLWGPAAVEHHKTRKSL GASLWKQASSDELLALLKTDRMLQTISQFPQQRRIIL------------- -------------------------xLYTNKA------------------ -------------------------------V------------KDLSNL YDPCFLLP----LFSVILRP-----------------------ECVIDCH KFISSHALGFTIMALSSSDPKVRAAAYHVLGSFYQHLEGARFREKRQMLY LMDIVKN------------------------------------------- ---------------------GIQRQNQRVPFVLTSYIAKVAQQMLRPED HMYVVLNKFLLSQQSLDLKRVPEFFKLFYSFDL----------------- -----------EHKMEREWILNVLGEGINDDHCFELCNQQGIFQSLLGFG SSPLCDETFQ-------VQIIRVLCKAARVTKGAYNLTKSSGILSWMIHF IEK-KNL----TQQLLCSVVDLLCVLWFTNLGEK-------------E-K K--ADGAG-ASSPSGEKPQGA--------------------------VKY LPLPFINEFLCAASAVCRHL-R---LGVKAAQLSMFVQMLSTALMH---- ---------RGTALSVNKQAEWLTLSPQPLSSAESLTLLHCWATL----- ------------SHNAALLSQIQELSNRHKVAEL-----MG--------- ----------------------------IGKDKFRGK------------- -------------------------------------------------x xx------------------------------------------------ ---------------------------xxTRGENSAEDDE---------- ----------------------ADKQ-ESL---------LRECKPSLCSI FIHWEPELY----------------------------------------- -------------------------------------------------S SEAQSAVSKDRLEPRLLACDTAHLLTRW--------------------SL KWLLE--DAYEDDKAKQFLLWFEKAVQRHGKMVKAVMLDPGLKADLLCLY HRSFET---------xxxxxx----------------------TLKKFTH IMIxxxxxxxxxxxxxxxxxx----------------------------- -------------------------------------------------- ------------------------E--------AG--------------- ------------LFLLSMFIHELWSGAASAELFLSYVGLV---------- ----TKTKN-QK---------------------------PKGSKS-SxTQ TAV----------------------RGIC-----------KEIVAIK--- --------I----- >ENSKMAP00000008742 -------------------------------------------------- -----MG-------------------KKRHSDVP-SESDPPQKKEKV--- ------------------PEFNGTEFKAMLRNPATAMK------------ -------------------G------------------------------ -----------------------------------------------LEK FTSTAKKLPCSDLYDVVEGYIKISMECADIFNLLEGEKHTETEMMLVFGS LEVILLRTASDLSHFNMVGNAIVKKIASSYMKLLQGSFYSSNHGFVRQCL NLLSAMVSQGVEAAREVLDHIQI-KTLSGLATRKDKRGKPDVRLAFIQFV LSFLVSGDSAVIRQTLELKELLPHILNTGLKEDRMSTVNLILSTLKSKVV LNKAISKTQKVRFFTPAVLANLASLYKWNGIADATTGDD---xVKDSDSS GLSVVRELVHSFLLDLCCSHKHGISFHDASLGTAGRAGNLVLLQFLVGLK QATEDELVADLVVNVLKTSPDILSRYFKETQYSYTPRLKSAWQDNVNLLK KIYEAQPDISTVFQNREMIPLPRLLSMIMVISVPPVCNKAFFTQGLNVSx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------- -----------------------------------------LRKILPDMT GIISSWQS-----------------------------LSKKE-------- -------------------------KAGVEDKETKREERPxxxxxxx--- -------------------------------------------------- -----------------------xxx-----------AEVILLKALILQV ICLYQKVVPHLVMQCKFDFSKLLK-------------------------- -------------------------------GIVSEKGMREEIPPILQYQ ILQLALDLPASKFSWCRI-------------------------------- ---------QDIAYS----E-SSSGEKSVLYLLLKMFV-SSNxSSHLRPS TQKL---VLKDTGVFEYTLPELELWLEQLARLEPNQQETVIQFLERVLVK LVCSSHEYTDKVASFVQEAGHLQANLSSQEGDAVSIAVSHI--------- ---------D---------------------------------------- --DVLDMLDVIMEGSDGEMEEFGPSLSEELIIQTFPFSTVVPAALEARNK L-----------P----ADK-------G--------VVCEYLCAVLSDVL HCQRDPLPLCLTLLQYDKELVF-SQLPASFYQ---SIVHLHQYSSRWLPQ QCRQQL-------------------------------------------- -----------FKS------------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------SECLTKEVSAPASCS-------------LLLKAA YVQGPAA----------------LLEDTFRQNIEKAVASMPLAEFPVVIK QVLLYIRSTVEDFGxxxx------------------xxx----------- --LMAKLQSFEETSN--------SKP------------------------ -----------------------ATxKSQ--------------------- -----------------------KESDL-----------FLEVDQSPTVE -------------ASKEQILVSALTSIFKHPCLEQWFLALELAAFPPHSL KPVALKHLCAQMTDNILTLLKISAPALNDLSHLELLCSYMVALERATLKE L--------QEK----GSRPPKTHSRTFQALLSLHSYMDSSNLRELVSQL LLLPHDSLIC----------P-SSEGTQSELSIYGQVALHILTKCTSTSY QDHS--RFLTQ--------------------------------------- ---AHLHGLGTLFVSCSSPELEAFMLQTLSYDPGSAKLIHTDVLLHCL-- ------Q----KPLRDSLAISSLLLENCSSHRLRFEVWCLE--------P SNMDKMS-ETDAF---FPLINTYLQVASREDPARPKDxxxxxxxxxxxxx xxxxxxxxxxxxxxxx---------------------------------- --------------------x----------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------RWQLVDVITEKLADSPVEQDKWRKCVMAA ALKCLIVSY-------------------------------CHx------- --------------AASTSAQEHSVLKRL-QHLLVx---SPADIT----- -------------ASDWNSFVKNGLRNRYSD------------------- ---------------------HHFLNTLSNVLELMYGSSEVQKDLIPLST LYMMTSSHSRFLPTMLDSSEEP-TR----------------xxxxxxxxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -F--R---------------------------SFLWGPAAVEHHKTRKSL GASLWKQPSSDDVLALLKTDAMIQTILKFPQQRRIL-------------- -----------------------xxLxxxNDA------------------ -------------------------------V------------KDLGSL YDPCFLLP----LFSAILRP-----------------------ECVIDCL KFASCHALGVTVMALSSYDPKVRAAAYHVLSCFYQHLEAARFREKRQLLY LMNIVKN------------------------------------------- ---------------------GIRKQNQRLPFILTSYINKVAQQMLRPED HMYVVLNRFLLAHHSLDLRRVPEFFKLFNGFEL----------------- -----------EHKIEREWILNVLEEGISDGHCYELCNQQGIFEVLLSFS SSPLCSEHFQ-------TQILRVLCRAARVTKAAYSLTKSCGLLSWMIQA VEK-RNL----NQQLLCAMIDLLHVLWFTILGQK-------------E-K K--VHEAS-TSSSTEEISQSL--------------------------MKC LPLLLVNEFLCVSLAICRH-------------xSLFVQTLCSVLTH---- ---------RGTALSVNKQADRLMLHPQPLSCTETLSLLLCWASL----- ------------SHHTPLLTQIQALSERNKLKQL-----MGxx------- ----------------------------VGKHKVRGK------------- ------S------------------------------------------- ------------------xxxxxxxxxx--------------------xx xxxxxx-------------------------------------------- -------------------------QEEKL---------LTDCKVHLSRI FVHWEPVFH----------------------------------------- -------------------------------------------------L SEPQPDQPRDKLDPSQLAGDTALLLTKW--------------------SL RWLVE--NPSDEYTTREFLHWFEKVTVKHRNIVNLAMLNFGLKADLLQLF HLTFEARRHSSFST--------------------------GAETLQLFTN IMI------------------CLLEMQG-HLPD--V-------------- -----------------HQA----------------------VIAA---- ----------CLxx--Q-DQSR--Q--------AG--------------- ------------LSLLSLYVHELWSGAASAELFLSHVRLV---------- ----TRDKN-KK---------------------------QKASKP-SxPQ TAI----------------------RAIC-----------NHIIVIK--- --------R----- >ENSCSEP00000019975 -------------------------------------------------- -----MG-------------------KKRSNEDL-x-SDTSAKKEKL--- ------------------EEFNGTMFKTMLKEGTTVRK------------ -------------------G------------------------------ -----------------------------------------------LET FISVAKKLPCPDLYDVVEGYIKISMECAEMFKLLDVEKHNESETVLVLES LEMILLRTASDLSHFNMVGNAIVKKIVSSYMKPLQGFLHSQNHRFVRQCL SLLSAMVAQGPAAAREVFSQIHINRSLSGLAKRKDKRGKPDVRMAFIQFV LSFLVSGDAATVGQILEVKELLPEILSTGLKEDRMSLVNLILTTLKTRVV LNKVLSKTQKVRFFTPPVLANIASLYKWNGVVDATTGDDK--x------T AVSVIRELVHSFLLDLCCSRKHGISFHDASYGTAGRAGNIVLLQFLVGLK QATEDELVAELVVNALKANPDILARYLKETQYSYTPRLKSAWQDNVRLLK KIYQVQPEISAVFQTGDVIPIPRLLSMIMVISLPPVCNKAFFTQGLSV-- ----------------------------------------TVQLTTLSMM SFVLKKAHMNIEYLVDKES-QNSDVYTDDEMADLVQQYREALTKILPDMT SIVAKWQS-----------------------------LSKKD-------- -------------------------KKAGEEK----------------xx xxx----------xx----------------------------------- ----------------------------------xxTAEVILLKALILQV ICLYQKVVPHLVNQCKFDFSKLLK-------------------------- -------------------------------GIVTEKGMRQEVPPVLQYQ ILQLALELPSSKFSWFRI-------------------------------- ---------QDTGDT----E-xx--EKSVLYLLLKMFV-SST-NNHLKAS TQMLVLKVLKDSGVFEYTWTELELWLAQLLKVAPDQQETVIRFLERVLGK LVCSSSTYTDKVASYVQEAAYLQSNLCNQEGEAASIPVSHI--------- ---------D---------------------------------------- --DVIDMLDVIMDGNDGQMEEFGPSLNEDLIIQTFPFSALVPAALEARNK L-----------P----SNI-------G--------VTHEYLCAVLCDVL HCQREPLPLCLALLQYDKELLS-SDPSASPHP---AVHHLHQYYNKWLP- ------------------------xxxxxxxxxxxxxxxxxx-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------PTSYS-------------ALMKAA YSQGTKA----------------FLEDTFVKNVDEALTSMSMDEFPVAIK QILLYIKSTVENFGxxx--------------------------------- ---------------------------xxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxx--xxxNLQ--------------------- -----------------------EGSDL-----------FLEINQSSAVE -------------TDKERILVTVLESVFKHPCLEQWFLALELSSLPPHTL KPVRLKKLCAQLTDDILALLKVSAPILQDLSHLQPLCSYTGTLERALLKE F--------SEQ-----SQDINTQSRPLQGLLSLHSYMDSSLLREVVSRL LLLPRERLLS----------P-ATKGTHVKLSVYGHAALQILTEHGANPS QDHG--TFLTK--------------------------------------- ---AHLSGLSTLLFSCTSPALESFMLQVLTTEPGSAKLIHTDVLLHCL-- ------Q----RPVADCLTIGSLLLRNSPAHRLRFELWCSE--------P ANIKKVSEETDIF---IPLINTYLQMAGRDDGARPKN------------- -------------------------------------------------- --------------------VQNNVLKSLKKALLAK-------------- ------------------------------------------------VS QCVLRTLTEESGDQF--AQTLVSLVQLS---------------xxxxxxx xxx----------------xxRWQLVEVISEKLADFPDELENWRTSVTAA AFRCLITSY-------------------------------SQSKDQ---- --------------TQTLSEQELGILGRL--------------------- --xxxxxxxxxxxATEWNSFVKNGLKYRYRD------------------- ---------------------HHFLNTLSTLLNLMYGDIEVSKDLLSLST LHMMTTSHSLFLPTMLE--EEP-SRSQAK--------------------- --------------------------------------------EALVSL LLCLVRKCPTVCSSSHFVIFLGAYGATLNISDQTLLLLLQEYEKNQVSLL KF--Q---------------------------SYLWGPAAVEHHKTRTSL GASLWKQASPDDILALLNPEQMLQTIAHFPQHRRLIPQxxx--------x xxxxxxxxx----------------------A------------------ -------------------------------L------------KDIGHF YDPCFLLP----LFSAILQP-----------------------ECVVDCF KFVSSHALGFTVMALSSYDTKLRAAAYHVLGCFYHHLEGARFREKRQLLY LMDMVKN------------------------------------------- ---------------------GIQKENLRLPFVMTTYIQKVAQLMLKPED HMYVVLNRFLLSHQSLDFKRVPEFFKLFYGFET----------------- -----------EHKVDREWILSVLEEGIADRHCFEQCDRQAIFQSLLGLS SSPLRDENSQ-------AQIIRVLCKAATVNKAAYNLTKTCGILTWMIQM IEK-R------DPHLLSSLIDLLHVLWFTNLGQK-------------E-K Q--VDExx---SSAEEKPKNL--------------------------IKC LPLPLINEFLCVALEFTKYL-R---LGLKAASLSRFLQTLCFVLKH---- ---------RGTALSVNKQAERFSLLPQPLSCAEVLAPLLCWASL----- ------------SGDKALTNQIHCLSEKSKTKEM-----LG--------- xxxxxxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------LTECKYYLSAI FIHWEPVFP----------------------------------------- -------------------------------------------------L SEPPQVQPGDRVALGQLACDTAHLLTKW--------------------SL RFLVE--SPYDEKRTEDLLHWVEKYLMKHQAIVDVLLLDPGLKADLLRLY HQAFESQ---------xxxxxxx-----------------RFKTLQQFTK IMM------------------RLLDSQG-QLPE--V-------------- -----------------HQA----------------------VVST---- ----------CLPGDTN-DLSRCxK--------TG--------------- ------------LYLLSLYIHELWSEATSAELFLSHVHLV---------- ----NKTMCxxx-------------------------------------- ---------------xxxxxxxxxxTAIC-----------SDIIAWKx-- --------x----- >ENSELUP00000020862 -------------------------------------------------- ----xMG-------------------KKRSSEDA-DQSSMQPKKGKVSV- -----------------xTEFNGTVFKAMLKEPSKAMK------------ -------------------G------------------------------ -----------------------------------------------LET FISISKKLPCPDLYDVVEGYIKISVECSEIFKLLEGDKKIDNEMMLIFQT LEMILLRTASDLSHFSMVGSTIVKKIVSCYMKLIQTSLSAENHRYVRQCL TLLSAMVSQGADTAREVFSHFHFSKGLSSLARRRDKMGRPDVRMAYIQFA LSFLVSGDNAMIGQLLEIKDFLPDILSSGLKEDRISIVNLILSTLQTKVV RSKAISKTQKVRFFTQSVLGQIATLYRWNGIVDASPDDNQ-----NADEA GKMVVRELVHKFLLDLCCSRKHGLSFYDPSFGTAGRAGNIVLLQFVVSLK QAAEDELVSDLLVNILRVSPDILPRFFKETQFSFTPRLKSAWTDNIALLK KIYESQPELSKAFQAREVVPLPRLLSMVLVTSLPPVCNKVFFTQGLNFS- --------------------------------------NMVVQHTTLSLM SFLLKRAWRNIEFCLDPSVWINSDVYTPAAMEEFVQLYREAFAKVLPDMT SIVSKWQS-----------------------------LTKxx-------- --------------xxxxxxxx---xxxx--------------------- -------------------------------------------------- ----------------------------------xxxPEVVFLKALILQV MRLYQKVVPHLVSQSKFDFSKLLK-------------------------- -------------------------------GIVTEKGVRQEVPPVLQHQ ILLLALELPASRFSWFRA-------------------------------- ---------Q----M----E-AASGERSVFYLLLKMFV-SSS-NSHLKLS TRKLVLKALRDTGVFEYTWSELELWLSHLARLEPVRQDTVVQFLERVLVR LVGNPHAYTDKVASLVQEAAYLQANLSGQEGDAVSIPVSHI--------- ---------D---------------------------------------- --DVLDMVDVILEGSEGEMEELGPELSDDLVLQTFPFSALIPAVLEARNK L-----------PxxxxAEQ-------G--------VLFEYISAVLCDVL HCQRDPLPLSLALLQYDKELSS-GGHPGPPHP---SVLHLHSYYSTWLPQ QTREQL-------------------------------------------- -----------FQSx----------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxxxxxxxx-----------SLT-------------GLLKEA YSQGSSG----------------LLEDSFRQRVEESLAATELHEFPVATK QVLLYVKTTVDNLS---------T-------------------------- -------------------------------------------------- ------------------------------xxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxx----------------------------- ------------------VVLSVLRSILKHPCIEQWFLCLELSSVPPTSL NPVRLKRLCAQLSDCVCALLVASAPTLRALDSLHLLRPYLEAVGRALLRE L--------GER-----TKERQEESRPVRALLALQAYMEPSLLQELVSSL LLLPKETLLIxxxxxxxxxxx-xx----TELSVYGRTALQILSATTSASS SSSxxxLLLSQ--------------------------------------- ---AHLQGLATLLLSCSSPSLEAFLLQALKSQPGNAKLIHTDVLLYCLxx xxxxxxx-----------ALAAALLTNCSTHRLYFEAWCLQ--------P EHTETLASQTDAF---LPLVNSYLQTAARQDPARPKE------------- -------------------------------------------------- --------------------VQTAVLKALKQALLPG-------------- ------------------------------------------------LT LCVLG---xxxxxxxxxVEALSSLLRLAAKVKDVRGLVDSLL-------- ----AALQKLDGF-E------SWQLVEPITTVLSDCQEDLAAWRRSVISA ALRWLISSF-------------------------------SHNREP---- --------------SAATLSQEDTMLKRL-TSLLT----LPEDVA----- -------------AAEWSSFIKTGLKCRYRD------------------- ---------------------PNFLSTLNGQLDLMYGGSGGPKDLVPLPT IHMMASSHSLFLPTML----------------xxxxxxxx---------- --------------------------------------------NALVTL LLNLVQRCPAVCNGSHFVVLMGAYG------------------------- ------------xxxxxxxxxxxxxxxxxxxxCLLWGPAAVEHHKTRRSL GVSLWQQPSSEDLLALLQPETMANTVRHFPLQRRIIIQxx---------- -------------------------QIFKDCE------------------ -------------------------------V------------KDLGSV YDPCFLLP----LFSAMLQP-----------------------ESVVDCL KFVSSHGLGVTVVSLSSYDPKLRAAAYQVLASYYHHLEAARFRERRQLLY LLDMVKN------------------------------------------- ---------------------GIGLQNLRMPFILTTYIAKVAQQMLRPEE HMYVVVNRFLLSQQSLNFRRVPEFFKLFFSCDM----------------- -----------EHKLEREWILSVLEEGLTDRHCYELLDQQGIFQTLLGFC CSPLCDDHTQ-------TRIVRVLHRAGHVTKAAYLLTQYHGLLVWILQL LER-RWV----DRRQLGTMLELLHGLWFTNLGQK-------------E-x x--xxxSx--CSTAEDKPKxx---------------------xx---PKV LPLPLINQFLCVATAIIRHL-R---L-VKAGQLSLYLQTLSSILHH---- ---------RDTALGAHREAGWLTLRPQTLSTVETLALLQRWSTL----- ------------THDAPLLSKLQAVAEKHRVKEL-----LG--------- ----------------------------SGREKGR--------------- -------------------------xxxxxxxxx--xxxxxxxxxxxxxx -------------------------------------------------- -------------------------------------------------- ------------------------REEEAL---------LEVCTPHLRSI FTHWEPVSPxxxxxxxxx-------------------------------- ----------------------------------xx-----------xxx xxx-------------LAYTTAHLLTRW--------------------SL NSLVExxSNYEEKATVSFLRWFQKTVLPHRDIMDMVLADPTVRLNLLRLY HVACE----------------------------xxxxxxxGLEHLQLFTS IMT------------------QLLEVQG---------------------- ----------------------x----------xxxxxxxx-VLGA---- --xxxxxxx-------D-DHATK-E--------AG--------------- ------------VVLLSLYIHELWSGAARPELLLSHARLVx----xx--- -xxxxxxxx-xx---------------------------xxxxxx----- ------------------------xRAIC-----------SNIL------ xxxxxxxAS----- >ENSCHAP00000013429 -------------------------------------------------- -----MS-------------------KKRQ-------------------- xxxxxxxxxxxxxxxxxxLEFNGTVFKTMLKDPTTVKK------------ -------------------G------------------------------ -----------------------------------------------LDT FIKAAQKLPCADIFDVVEGYIRISAECTEILKLLEEENKVEHKMVLVLQS LEVILLRIASDLSHFSIVGSTIVRKIASTHMKLLQTFLHSENSRFVRQCL TFMAAMVSQGPESAREVFSQLHFGKALSGLAQRRDKTGRPDVRMVYIQFS ISFLLSGDNSTIGQLLETKDFLANILSSGIKEDRISLVNLILATLQSKVV QNKAISKTQKVRFFTPAVLSNIASLYRWNGIVDSEIDxx--------EEA GKIVVREQVHSFLLDLCCSRKHGLSFHDQSLGTVGRAGNIVLLQFLVGLK DSTKDDLISELVVSILKSSPDVLARYLKESVHSYIPRPKSAWQDNISLLK KIYEAQPEVSKAFQTREFIPLPRLLTMVMVTSLPTVCNKAFFTQGLNCK- --------------------------------------NTVVQHTALSMA SFILKRALKNVEHCLDKSVWQCSDIYTPAIMEDFVQLYREALSKVLPDMT SVVYQWQL-----------------------------LTKKE-------- -------------------------K------------------------ ------------------------------------------------xx xxxxxxxxxxxxxxxxx-----------------GDETQVILLKAVILQV MCLYQRVVPHLVSQSRFDFSKLLKx---------------------TVTE LFILFFSHV------------------FTFSGIVTEKGMKEEVPPILQYQ ILQLALELPASKFSWFRV-------------------------------- ---------Qxxx-----------GEKSVFYLLLKMFA-SSN-TSHLKTS TRMLVLKVLKDSGVFEHTWRELDLWLDHLACLEPSDQEPIIQFLDRVLVK LLCNPHKYTDKAAGLVQEAAYLQASLSGQDGDAVSIPISHI--------- ---------D---------------------------------------- --DVLDMVDVIMEGSEGEIEQLGPALTDDLIMQSFPFSAIVPAVLEARND L-----------PxxxxEEK-------G--------VLYEYLSAVLCDVL HWQRDPLPLCLTLQQYDKELHSxxxAKGPPHP---SVVELHHYYSKWLPQ SSQETL-------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxx--------------GAPSPAGFS-------------AVMRAA YSQGPTA----------------LLQDTLRQSAEESLSSLELLRFPNTVC QLLLYIRSTVESLS---------S-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxLTVLKSIFKHPCLEQWFFALELGTLPAHSL NPVQLKRLCAQFSGGILSLLQATIGTLSQLGALDLIGGYLSAVQRALLKE L--------EEVxxxxxxxCHAEESLALKALLALHKHMEVAGLKEVVSAL LLLPKESLVV------------xTEESRSQLSVYGAVALQVLTE---xLS QDGA--LYLSR--------------------------------------- ---AHLCGLATLLTSCRSAALEDFFLQALTSDPGSGKLVQTDVLLYCA-- ------QxxxxADSSSTQAVGSLLLQNCSTHRLRFELWCLExxxxxxxxx xxx--------AV---LTLLSSYLKVAAREDPARPFE------------- -------------------------------------------------- --------------------VRTAVLTALKKTLLGP-------------- ------------------------------xxxxxxxxxxxxxxxxx--- -----------------VEVLSNLIKLAAEASDVLSLMPDLI-------- ----AILQKPQSY-A------RWQLADAISTKLEDSSELLESWRKSQLSA ALRWLVASY-------------------------------SSCKEK---- --------------ESAHLDQEETVLQRL-EG--xxxx-SPEHVA----- -------------ASDWNSFVKSGLKYRYTH------------------- ---------------------HALLSTLTSIVDLLYGDPDPPKALLPLAT IHMMSSSHSLFLPAMLGTEDDPxxxxxTK--------------------- --------------------------------------------EALISL SLALVKRCPSLCEMRHFVVLLGAYGATLSTADQKLLLLLQEYEKNDFSLV EF--Q---------------------------SLLWGSAAVEHHKTRKSM GPSLWQQPSSEELLALLNPARMLRTVSHFPQQRRILPQ------------ ---------------------DGKELIYKGEGx----------------- --------------------------------------------LDLADL YDPCFLLP----LFSAMLRP-----------------------ESVIDCL KFVSSDAFGVAVAALSSYDPKLRAAAYQVLGSFYQHLEGARFKEKRQLLY LLDTVKN------------------------------------------- ---------------------GIKQQNLRVPFVMTTYVAKVAQQMLRPE- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxxQHKVEREWMLSVLEEGVTDRHCYELCDQQGLYFTLLGFC SSPLCEESTQ-------ILIINVLRKTAHVTKGAYNLTKAHGLLMWLLQL LER-RFV----DPRLLSAIVDLAHTLWFTNLGQK-------------E-S R--AEQIS-SAAEDKDKPQPA--------------------------VKC LPLPLINEFLCLLLGVIKHL-K--xAGVKAPQLKPFLQTLSSVLMH---- ---------RGIALGVHSDAGWLTLKPPLLSSSDVLSLLHRWGTL----- ------------AHDTALLASLQGLATTCQLKDL-----LG--------- ----------------------------AGRERGRAK------------- ------Gx---------------------xxxxxxxxxxxxxxxx----- -------------------------------------------------- -------------------------------------xxE---------- ----------------------SEKRDQSL---------LDECKPHLRHI FTHWEP-----------x-------------------------------- --------------xxxxxxxxxxxxx-----xxxx-----------x-- ---------DSIDPVCKSRATASLLIKW--------------------TL QTLAL--APYDGSSVLSFLKWVRIVVLPHKGIIDALMADVAIKMAFLRLY HQVCECGDPAQGSS--------------------------RADTLSLFTS IML------------------PLLESQGxxxxP--L-------------- -----------------HQT----------------------VVTA---- ----------CLPTSTD-DHTGR-E--------AG--------------- ------------LLLLSLYVHELWSGVESAELFLTHVRLVxxx------- ------------------------------------xxxVKExxx----- -----------------------xxVDIC-----------REILT----- -xxxxxxST----- >ENSDARP00000154940 -------------------------------------------------- -----MA-------------------TKRENEENxTESVTKAKKGKTDxx -------------------EFSGTVFKSMLKDSSEAQK------------ -------------------G------------------------------ -----------------------------------------------LAT FIRVAKTLPCAELYDVVEGYIKISAECSEIFALLDEE-xxEKEMMLIFQC LEMILLRTASDLSQFSMVGANIVRRIVSKHMTLLQSSLYSKNYRFVRQCL SLLSALVSQSADAARDVFGQMQFGKDLCQLARKRDKSGKSDVRMAFIQFV LSFLMSGDNTTIGQILDTKE-LSEILNSGLKEDRLSIINLILSTLQTKVV QNKTITKTQKVRFFSASILAQIASLYRWNGIVDVSVDEEx-----KVEEG GKHIMRELVHNFLMDLCCSRKHGISFHDPSLGTAGKVGNLVLLQFLVRLK QATEDEMVAELVVNVLKGSPDILNRYFKETQCSFAPRNNKTWQDNISLLK KIYEVQPVVSKAFQMNEMVPFPRLLSMVLVTSLPPVCNKVFFTQGLNVH- --------------------------------------SLVVQHTTLSLL AFILKRAQQNIEYCLDRTVWETSDIYSPAMMEEFVQLYREALSKILPDMV SIVSIWQLxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- ----------------------------------------ILVKALLLQV MCLYQKVVPHLVTQSRFDFSKLLKxRxxxxxxNRFSKxxxDLGKAKRIxx x----------------------------FAGIVTESGMTQEVPPVLQYQ ILQLALELPASKFSWFRV-------------------------------- ---------QEMANP----D-FEKGEKSVIYLLLKMFV-SSN-NSYLKTS SRMLVLKVLRDSGVFEHTWKELELWLDHLTMLGLSQQETVIQFLDHVLTR VVCNSHVYTDKAASMVQEAANLQANLNGQDGDEASIPISHI--------- ---------D---------------------------------------- --DVLDMVDVIVESSEGDIEEIGPSLTEDIILQTFPFSAVVPAVLEARNK L-----------PxxxxDAK-------G--------VLYEYMAAVLCDVL HCQRDPLALCLTLQHYDKEL-xxSDAASTPHA---SVVSFYHYYSQWLPK NTHHTL-------------------------------------------- -----------Fxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---xxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------LAVLKSVFKHPAVEQWFLALELSSFPPHSL NPVRLKQLCVCLTEMTLLLLESSADTLRDLDALELISTYLTSPQRAVLRE L--------QEM----KSNCPKKESLSVRALLALQEYIEPSSFKEVVSTL LLLPQKHLLA----------------xENQLSVYG--------------- ----------xxxxxxxxxxxxxxxxxxxxxxx----------------- xxxAHLQGLAALFTSCQCVQLEDFLLQVLSREPGTAKLIQTDILLHCI-- ------Q----RESPSAQDIGVVLLENCSTHVLSFELWCLD--------P SNQKQISVQNGSF---LSLLNSYLKRSTADDPTRPKD------------- -------------------------------------------------- --------------------VQKSVLKVLKNALMAE-------------- ------------------------------xxxxxxxxxxxxxxxxx--- -----------------VEVLSSLIRLAAVNSDLIQLIKDLP-------- ----AILQKPDTY-E------RWKLADSISEKLCDDSEELHQWRKSLLSA ALVWLTAVY-------------------------------xxxxxx---- --------------xxxx---EESMLTRL-RSLLLxxx-FPENMT----- -------------ASDWNAFVKSGLKHRYHD------------------- ---------------------CNFLETLNSLVEVIYDTPDTPKEMLPVAT IHMMTTTHSLFLPTMLAIDTD--xxxLxK--------------------- --------------------------------------------ESLVSL LLTLVRKSPEVCNVNHFLVLLGAYEASLSTTDQKLLLVLQEYEKNNISLA EF--Q---------------------------FVLWGPAAVEHHKTRKSL GPSLWQKPTSEHLLSLLSADRMLNTVTHFPQRRYIIPQ------------ ---------------------VNKTMIYIQxxxxx--------------- --------------------------------------------VDLSSL YDPCFLLP----LFSFILQP-----------------------ECAVDCL KFVSCQALGVTMAALSSYDSKVRAAAYQVLGSFYQHLEGARFKEKRQLLY LLDTVKN------------------------------------------- ---------------------GIQKQNLRVPFVHVAYIAKVAQQILRPEE HMYMVVSRFLLGTQFLDLKRVPDFFKLFYSFEL----------------- -----------EHKLEREWILSVLEEGVWDQSCYELCEMQRIYQTLLAFA STSLCDQATQ-------IQIVRVLRQTARVNRAAYILTKEHGVLTWIVQL IEK-RYV----DSKLLSSVIELLHALWFTNLGDK-------------E-S K--AExxx-xxxx---QPQTS--------------------------GKC LPLPIINEFLCTLLTVIRHL-R---SGVSGLQLQQFLHTLSSVLVH---- ---------CGTAMNAYKEAGWLTLHPHKLSCSEVLSLLQRWTAL----- ------------SHDASLASALQTVGNKHKVKEL-----MG--------- ----------------------------SGREKGQGKxxxxxxxxxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------DQAV---------LDECKPHLRNI LLHWEP-----------xxxxxxxxxxxxx-------------------- ---xxxxxxxxxxxx----------------------------------- --------------------TACVIFKW--------------------AL KTLTE--SRFDDKCTLALLKWTHSTIMPHRSITDAVLSDEGVRKDLLRLF H------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxHQT----------------------LIQT---- ----------CLLTNTD-DEAKK-E--------TG--------------- ------------LNLLSLYLYELWSEAQSPDLLLTHARLIxxxxxx---- ----------xx------------------xxxxxxx------------- ---------------------------IC-----------RDIL------ ----xxxxS----- >ENSIPUP00000021718 -------------------------------------------------- -----MT-------------------NKRKNTD--FKSLIPEKKAKEFx- ------------------SDFNGTVFKFMLKDPSKAFK------------ -------------------A------------------------------ -----------------------------------------------LET FIQTAKQLPCANLYDVVEGYIKISTECAEILALLEGDTHSETELMLIFQS LELILLRTASDLSHFNLMGSSIVKKTVSSHMKLLQSTLCSGNRQLVRQCL CLMTVMVSQGTEAACEIFSSLVFNKTLSSLARMRDRTGRPDVRMSYIQFA LSFLMYGDTATIVHVLDTKDFLSEILNTGLKEDRISTISLILSTFQTKIV QNTAVSKTQKLHFFTASTLTLIASLYKWNGTVDISTDHS---xTMNEQEG GRLVVRESVHSFLLALCCSRKHGISFHDPSLGTAGRAGNIVLLQFVVSLK QAIEDQKVAELLVSILKCNPDILHRYFIETHLCFTPRMKGAWLDSIALLK KIYQSQPEVSQAFQLQEVVPVPHFLSMVLVTSLPPVCNKSFFNQGLKLP- --------------------------------------SVMGQHATLTVI AFILRRAQKNMEHSLKSPVFDSFDSHSLNAKEEFAQLYREALSKVLPDIM SIVSIWQS-----------------------------LSKNE-------- -------------------------KKEDEV------------------- ------------------------xxxxxxxxxxxxxxx----------- ----------------x-----------------DGNQKLILFKALLLQV MCLYHKVVPHLVTESKFDFSKLLK-------------------------- -------------------------------GIVSEKGMKEDVPPILQYQ VLQLALELPANKFTWFRF-------------------------------- ---------QDVVAPxxxxx-----NRSVLYVLLKMFV-NSS-NTHLKTT TRMLILKVLRGSGAFEHNWKELELWLDHLLHLEPSQQETVIQFLDLVLMR VVFNPYIYMDKVAVMVQEAVCLQAKMRGPDRNTTGVPISHI--------- ---------D---------------------------------------- --DVPGVIDVVIEASEKDADSVGLSLTDDNILQIFPFSAVVPAVLEDRNK Q-----------KxxxxEEK-------S--------VLCEYICAVLCDIL HSQMDPLALCLTLQNYDAELLS-SENFSPPHP---SVSAFRIYYFKWLSH LHQETQ-------------------------xxxxxxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------DFS-------------AYLKAC YCEGPGT----------------FLQDSFWKGLEQSLSTLKLSDFIGAVS QTLIYLKSFVETFC---------SLPRDQAVEVVR---------CMLEVL HALFLKLFSITETPP------xxxxxx----------------------- -------------------------------------------------- -----------------------xxxx---------xxxFLDMNFTATQE -------------VNKEQVLLVVFRLVFKHPVLQQWFLAVELGVIPYLSL DSERVRQLCGQLTQGVLNLLMSCVETLRALHALEVISSYFTVVKRALLSE L--------xx-----SNRGLVEESHTVEAFLALYEYMDPSNVSEVLSAL LLLPQSSLLA----------G------GDKMSLYGHVVLTVLTK------ -------------------------------------xxxxxxxxxxxxx xxxVHLHSLAALHSSCYSVQLEDIFLQVLHREPGCAKLIPTDVLLHCL-- ------Qx------SSSLELAALLVQNCSTHCLAFELWCLE--------Q TDLAHITAENSSF---LSLLSSYLQKVTTEDPCRPKD------------- -------------------------------------------------- --------------------VQKAVMQMLTKAMLSE-------------- ------------------------------xxxxxxxxxxxxxxxxx--- -----------------VELLSGLIPLGAMASDLTQLIHDLP-------- ----VLLENPETSxQ------RWQLADLITEKLMSTPEQL-xWRKSLLTS ALRWLSTTY----------------------------------KEH---- --------------KKPLIKTEEAMLQRL-KTLQI----SRENIT----- -------------DFDWNVFVKSGLKYRYKD------------------- ---------------------KMFLCTLNSLLEPMYRSALTSKGLLPIET LHMMVTSHSLFLPTMLVSQDDTxxxxxSK--------------------- --------------------------------------------EALITL LLTLVKKCPEVCKSNHFHVLLGAYGATLSYTDQKMLLLLKEYENNSMSLM EF--Q---------------------------YLLWGQAAVEHHKARKSL GPSLWQQLSSEPLLDQLVADRMLYTVAHFPLHRCLFPQ------------ ---------------------ENEE-x----------------------- ----xxxxxxxxxxxxx--------------------------------F YDPSFLLP----LFSFIVRP-----------------------ESLLDCR KFVCSHALGFTVVALSSYDHKMRAAAYHVLGLFYQHLESVHFKEKKQLLY LLDTLRN------------------------------------------- ---------------------AIQKQNLRVSFMHASYIAKVVQQILRPEE HMYLVISKFLLGTQYVDLKRVPDFFRLFYSFDL----------------- -----------EHKLERDWLLKVLEEGMRDGLCYELCEQQSIFHTLLGFC SSPLCDQPV---------xIMNILGETAHLPKASYDFSQAHGILTWILQL TERSRNV----DRTMLTVVIGLLHTLWFSILGKT-------------D-S R--VQ----WSSRADKQINSLx--------------------------KC LTFSLISDFLCALLSVIRYL-R---TGVEPYDVERFLQMLDSVLKL---- ---------HGTSLNGSRDTNWx--HPQTLSCSAALTLLHCWGTL----- ------------ASDTTLLYGLQDL------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxxxxx xxxxxxxx----------xxxxxxxxxxxxxxx------xxKCKPLLLSV LTHWEP---------------------xxxxxxxxxxxxxxxxxxxxxxx xxxxxx-------------------xx----------------------- ---------------SLITATAHALIKW--------------------TL RTLSE--MPFDEYHTFATLKWLEKLIGPHEPIAKSLITDEFVRVDLLRLY HQTCEFKVQEQSTF--------------------------KLDTLQLFTK IMV------------------CLLEVE----xx--L-------------- -----------------HTN----------------------VIKA---- ----------CLYSTAD-DLVKR-E--------AG--------------- ------------LKLLSLYLPEIWSGAMVPQLLLTHAQLI---------- ----TRRRK-NS---------------------------KKKSR------ TPI----------------------MQIC-----------EDILSAV--- ---x---------- >ENSPNAP00000013463 -------------------------------------------------- -----MA-------------------KKRQNAEP-LESLMPANKKKTTx- ------------------SEFNGTVFKSMLKDPSSAFK------------ -------------------G------------------------------ -----------------------------------------------LEI FIRTAKKLPCANLYDVVEGYIKISAECSEILLLLEGDTHSETELMLIFQS LEMIFLRTASDLSHFTMVGSTVVKKIVSTHMKLLQSSLCSVNRQFVQQCL RLLAAMVSQGADSAREIFSSLVYTKTLSSLARIRDXKGRPDVRMAYIQFV LSFMMCGDSSLVGHILDTKDFLTEILNTGLKEDRISIVSLILATLKTKVV HNTAISKSQKVRFFSASTLAQIASLYRWNGILDTTTFHS---xEVTQQEG GRLLVRDLVHNFLLDVCCSHKYGISFHDPSLGTAMRAGNIVLLQFVVGLK QAAEDDLLAELLVSILKCNPDILPRYFKETHFSFTPRMKGAWLDSIALLK KIYQAQPEVSQAFQLQEMLPVPRLLSMVLVTSLPPVCNKTFFTQGLKLP- --------------------------------------SVVGQQVTLSVL VFILRRAQKNIEYSLKRPVWDGSDSHSPTSMEEFVQLYREALSKVLPDVI SIVSMWQS-----------------------------LSKKE-------- -------------------------KEEGEEN------------------ ---------------xxxxxxxxxx-------xxxxxxx----------- ----------------x-----------------EQDPALIQFKALLLQV LRLYHSVVPHFISQSKFDFSKLLQ-------------------------- -------------------------------GIVSVKEMRNEVPPVLQYQ ILQLALELPASKFSWFRF-------------------------------- ---------QDGVNP----G-PARGEVSVFYQLLKMFIxSSS-SSHLRTS TRKLVLKVLKDSGVFEHTWRELELWVDHLLPLEPSQQEEAIQFLDQVLMK VVCNPYEYMDKVVAMVQETVCLQAEMSGQNR------------------- ----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx---------------------------VLQTFPFSALVPAVLEARNK L-----------LxxxxDEK-------A--------VLCEYMCAALCDIL HSQRDPLTLCLTLQHYDKELLS-AENSRPPHS---CLTSFCLYYSQWLPQ KPEETW-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxAFLKMC YSEGPDA----------------FLRDSFKSALERSMSTLQLSQFTGAVT QVLLYLKSFVDAFS---------MLPKGQAAEVVG---------CVLEVL GAVLHNLHSTAETTP------xxxxxxx---------------------- -------------------------------------------------- -----------------------EPQELxxxxxxxxx-----------QE -------------VNKEQVLLFVFNSVFTHPVLQQWFLAVELDVVPHHSL EVDRVRQLCVQLTQGVLNLLLSFAETVKALNALELISPYLSAAHQAMLKE L--------QH-----xxRCLNEESQSVKAFLALYDYMEPSSVNEVLSAL LLLPQSSLLA----------D------GDKLSLYGHAVLKVLTKSSAPPG KINT--LYLSS--------------------------------------- ---ENLRSLATLYTSCHSAQLENVLLQVLQREPWNAKLVPTDVLLHCL-- ------Qx------CSNLDLAALLVQNCSTHCLSFELWCLE--------Q SDLADITAKNNSF---LCLLTSYIRQAVTLDPCRPKD------------- -------------------------------------------------- --------------------IQNTVLQMLTKTFLTE-------------- ------------------------------xxxxxxxxxxxxxxxxx--- -----------------MEILSSLIQLGDMAPELYQLISDLP-------- ----ANLKKPENY-E------RWQLADSITEKLANTPEEL-xWRESLLTA ALHWLSTTY----------------------------------KEQ---- --------------KTPQFTKEEVMLKRL-KTLLI----SPENLK----- -------------AVDWNVFVKSGLKYRYQD------------------- ---------------------QRFLVTFNTLLELVYKNVNASKELLAIEA LHMMVTSHSLFLPTMLSSQNETxxxxxCK--------------------- --------------------------------------------EALVSL LLTLVKKCPEVCNSNHFPVLLAAYGATLNPTDQKLLLLLQEYEKKNISLV EF--Q---------------------------CLLWGPAAMNYQKTRKCL GPSLWQQPSSEQLLAQLAADRMLNTVALFPLHRRLVPQ------------ ---------------------EGEEVI----------------------- ----xxxxxxxxxxxxx--------------------------------L YDPCFLLP----LFSFILRP-----------------------ESVVDCQ KFVSCHALGVTVVALSSYDHKMRSAAYHVLCSFYEHLEGAHFREKKQLLY LLDTVKN------------------------------------------- ---------------------GIQKQNLKVPFVHTTYIAKVAQQILRPED HLYPVINRFLLGTQCVDLNRVPDFFRLFYSFDL----------------- -----------EHKLERDWMLNVLEEGMMDRLSFNLCEQQSIYHTLLGFC SSPLCDQHIQ-------IQIMNILRKSAHVIRAAYDLTKAHGVLTWIIQI TEK-RCL----NGKLLSAVIGLLHSLWFTNLGEK-------------E-S S------------------xxxxxxxxxxxxxxxxx-----------AKC FPLPIISDYLYALLSVIRHL-R---SGVEIKELQWFLQTLGSVLRH---- ---------QKMSLGAYEDAGWLTMHPHNLSCTAVLRLIHCWGTL----- ------------THDKALLFDLHDLAYKHSIRGL-----LE--------- ----------------------------TDKEKIRGK------------- -------------------------------------------------- ---xxxxxxxxxxxxx---------------------------------- -------------------------------------------------- --------------------------------xxxxxxxLDECKSMLMNI LTNWEP---------------------xxxxxx----------------- --------------------------xxxxxxxxx--------------- ------------DSSSLICATAHNILKW--------------------IL KTLSE--MSYDQSNTCTVLKWLQSVLLSYKTIADSLLSNEAMRVHLLRLY HQTCEHRLHEKSIS--------------------------KLDAVELFTS IMM------------------HLLEVER-SSEA--L-------------- -----------------HKS----------------------MIKA---- ----------CLHTTTD-EGPKR-E--------AG--------------- ------------LKLLSLYIHELWSGAKVPQLLLTHAKLV---------- ----TRDRK-KS---------------------------QKSSK------ xPV----------------------VHLC-----------KDILSAL--- ---xxxxIT----- >ENSAMXP00000012679 -------------------------------------------------- -----MA-------------------SKRRSALP-AEALRSAKSPKTGx- ------------------TEFNGTLFKSMLKDPGSAFR------------ -------------------G------------------------------ -----------------------------------------------LEI FVRTGKKLPCAGLYDVVEGYIKISAECCEIVELLEGESQSVTELMLIFRS LELILLRTASDLSHFSMVGTTVVKKILSTHAKLLQSSLCSVNHQFVRQCL SLLSAMVSQGANSAREVFSILVFSKSLNSLARQRDRTGRLDVRMAYVQFA LSFLMCGDSSIVGKILDAKDFLCDILSTGLKEDRISIVSLILSTLQTKVV HNPAINKSQKLRFFSAATLAQIASLYKWNGIVDSST--------xDSQGE GKLLVRELVHNFLLDLCCSHKHGIGFHDPSLGTATRAGNLVLLQFVVGLK QATEDELVCELLVSILKCSPDILPRYFKETNFSFTPRVAGAWLDSVALLK KIYEAQSEVSQALQLQEAVTVPRLLSMVLITSLPPVCTKSFFNQGFKLP- --------------------------------------SVEGQHATVSIL AFILRRAEKNMEYSLKTPVLNCLDTSTPTTMEEFVQLYRESLSKILPDVT SIVSVWQS-----------------------------LSKTE-------- -------------------------KEESEVI------------------ ---------------xxxxxxxxxx-------xxxxxxxxx--------- ---------------xx-----------------KQNPKLVLLKALLLQV LCLYQRVVPHLISQSKFDFSKLLK-------------------------- -------------------------------GIVSEKGLERNVPPVLQFE ILKLALELPASKFSWFRL-------------------------------- ---------QE-xNP----E-VARGEGSVFHLLLKMFI-SSS-SIHLRTL TRMLVLKVLRDSGVFEHSSRELELWVDHLQSLEPPQQDRVIQFLDQALMR VMCNPYIYLDKVAAVAQEALGLQAELSGRDREPCDLPGSHIxxxxxxxxx xxxxxxxxxx---------------------------------------- --x---------------------------VLQTFPFSALVPAVLETRNK L-----------LxxxxxEx-------S--------x-CEYICAVLCDVL HCQRSPVSLCLTLQQYDKELLS-AEISTLPHP---SM-SFCLYYSKWLPQ QPQETW-------------------------xxxxxxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------NLA-------------AWLKSC YTEGPQT----------------FLQDSFRPAMEKSLSSLQLSQFTGAVN QVLLYINSFVDAFS---------SLPRSNSVQILG---------CVLEVL DALLLKLYSTAEAPP------xxxx------------------------- -------------------------------------------------- ------------------------------------x-----------xx xxxxxxxxxxxxxVSSEQVLLAVFRSVFKHPVLEQWFLAVELDVVPPNSL ESDRIGHLCAQLTEFVLNLLQSSAEKLRALQALELISPYLSASQQALLKE L--------HH-----SSRCLKEDSRSVRAFLALCEYMDPAGVREVLSEL LLLPRSCLHT----------G------DEKLSVYGHAVLHILSKSSAQHG KSSS--LCLSS--------------------------------------- ---AHLQSLAALHTSCHWVQLEDVLLQVLQRDRGSAKLVPTDVLIQCL-- ------Qx------xxxxxxxALLVQNCSTHCLSFELWCLE--------Q SNLSWITAPNSSF---LCLLVSYTQQALTPDPCRPEH------------- -------------------------------------------------- --------------------IQKMALKKITKALVDK-------------- ------------------------------xxxxxxxxxxxxxxxxx--- -----------------MEIFSSLIRLEAMTPTLPQLICDLP-------- ----TLLKKPKGY-E------RWQLTDSITEKLANTSEEL-xWRTCLITA AFQWLSATY----------------------------------KEQ---- --------------KETQVQKEKAILRRL-RTLLI----SPENVR----- -------------ALDWNVFVKCGLKYRYQD------------------- ---------------------REFLTVLEMLLEKMYGDVNASKELLAVET LHMMVTSHSLFLPTMLAFQNExxxxxECK--------------------- --------------------------------------------EALVSL LLTLVKKCPQVCNSSQVPVLLGAYGATLDPADQKLLLLLREYETIN-SQA EL--Q---------------------------CLLWGPEAVEFHKARKQL GPSLWQQPSSEQVLAQLAPDRMLNTVTHFPLHRCLIPQ------------ ---------------------EGEELI----------------------- ----xxxExxxxxxxxx--------------------------------L YDPCFLLP----LFSFILRP-----------------------ESVVDCQ KFVSCHALAVTVVALSSRDLKMRSAASHVLTSFYEHLEGARFRGKKQILY LMDTVRN------------------------------------------- ---------------------GIQKQNFRLSLVHTTYIAKVAQQMLRPEE HMYLVINRFLLGTQYMDLGRIPNFFKLFYSFDF----------------- -----------EHKLERQWMLSVLEESVMDKLSFDLCEKQNVYHALLGFC SSPLCEQSVQ-------IQIVNILKKSAHIPKAAHSLTQAHGVLTWITQL IGN-RCP----DGRLVSAVIALLYSLWFFNLGQKxxxxxxxxxxxxx--- ------------------------------------------------KC FTFPVINDFLCALLSVIRHL-R---NGVEATAVQLFVQTLASVLKH---- ---------HKKSLGAHTDAGWLTVPPHTLSCSSSLSVLHCWATL----- ------------THDQPLLSALQALAKTHNIKGL-----FE--------- ----------------------------SVKERVQGK------------- -------------------------------------------------- ---xxxxxxxxxxxxx---------------------------------- -------------------------------------------------- --------------------------------xxxxxxxLEACRPLLMSI LTHWEP---------------------xxxxxx----------------- --------------------------xxxxxxxxx--------------- ------------DSSSLVGRTGYTLIKW--------------------TL KTLCE--GSYEESSICAAVEWLHRVILSHKTIAQSLVSDEAVKVDLLRLY HQTCQCRVQ----x--------------------------xxDTLQLLTT VML------------------HLLEVQ----------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xxxxxxxxxxxxLKLLSLYIHELWNGGKVPQLLLTHVQLV---------- ----TRDEK-KS---------------------------KKxxxx----G ASV----------------------LHLC-----------KDVLSAL--- ---xxxxST----- >ENSEEEP00000015324 -------------------------------------------------- -----NG-------------------TKQx-------------------- -------------------------------------xxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxG------------------------------ -----------------------------------------------LET FIKTAKKLPCDNLYDVVEGYIKISAECAEIVSLLDGDNTSEAELMLIFQS LEQILLRTASDLSHFRVVGSAVVKKTVSANMKLLKSSLYSVNYQFVRQCL CLLAAMVSQGADAAREIFSSLVFSKTLSSLARRRDSTGRPDIRMAYIQFA LSFLMYGDSSTVGHVVDTRDFLTDIFCTGLKEDRISIVNLILSTLQTKLV QNTAISKTQKVRLFNASTLAHIASLYRWNGIVDVTTDHS-------xVEG GRVFVRELVHNFLLDLCCSRKHGISFHDPSLGTSGRAGNIVLLQFVVNLK QATEDELVADLLVSILKCNPDILTRYFRETQFSFIPRMKGAWLDSIALLK KIYQAQPEISMVFHLKEMVPASHLLSMVLITSLPPVCNKAFFIQGLSVP- --------------------------------------SVVGQHATLSVL AFILRRAQKNMEHCLKKS-WESFDAHSPTAMEEFVQLYREELSKILPDVM SIVTKWQS-----------------------------LSKKE-------- -------------------------RE----------------------- -------------------------------------------------- ----------------------------------xxxPKLIVFKALLLQV ICLYQRVVPHLISQCKFDFSKLLKGK------------------------ ---------------xxxxxx----------GIVSEKGMK-xVPPVLQYQ ILQMSLELPPSKFSWFKL-------------------------------- ---------QDVVDP----C-QARGEQSVLYVLLKMFV-SSS-SCHLKTS TRKLILKVLRDSGIFEHTWRELELWLDHLLCLKQSQQETVIQFLDQVLMR VVSDPFVYMDKIAAMVQHTxx------GQDRDTDSIPISHI--------- ---------D---------------------------------------- --DDQVICNVVMESSGKDNEEIGLFPTDDIILQAFPFSVVVPAVLEARNT Q-----------LxxxxDEK-------G--------VVCEYICAVLCDIL HCQRDPLALCLTLHHYDMKLLS-AENx----xxxxCLTAFIQYYYKWLPH PLQET--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxFLTDSFRQALENSLCTLHLSQFTRAVN QTLLYLRSFVDTFS---------SLPKGQAVEVVS---------CLLEVL HALLLKVQSMAETQP------xxxxxx----------------------- -------------------------------------------------- -----------------------EQEELxxxxxxx--------------- ------------------xLVEVFQSVFKHPVLEQWFLAVELGLVPHLSL EPGRVEQLCGCLTEGVLLLLQSCAKTLGELRVSELISHYMSTTQHTLLKE I--------QHI----NNRCLTKETPPVKAFLALHEYMEPSSVKTLLSAL LLLPQSSLLA----------E------SDKLSVYGQAILKVLTNASA--- -------xxxx---------------------xxxxxx------------ xxxAHLHSLAILYMSCHSVPLEDFLLQVLRREPDSAKLIPTDVLLCCL-- ------Kx------NSRLDLAAVLVQNCSTHCLSFELWCLE--------Q TSFIEIAAQNSSF---LFLLTNYLEQAATEDPCRPKN------------- -------------------------------------------------- --------------------VQKAVLQMFTQSLLPE-------------- ------------------------------xxxxxxxxxxxxxxxxx--- -----------------VEVLSRLIGLGDMTPELNQLINDLP-------- ----AVLHKPEIY-E------RWQLADSITEKLANxxxxx-HWKKSLLTA TLRCLSTTY----------------------------------KEQ---- --------------KKPQVTTEKAMLQRL-KTLLI----SPEDIE----- -------------QSDWNSFVKSGLKYRYQD------------------- ---------------------GMFLDALNSLLELMYTNVKAAQGLIPLVT INMMATSHSLFLPTMLASQDEAxx-------------------------- --------------------------------------------RGLVSL LLTLVKKCPEICSSHHFIVLLGAYEATLSNTDQKLLLLMKEYENRDVGIA DV--Q---------------------------CMLWGATAVEYHKARKSL GPSLWQQPTSEQLLAQLATDRMLKTVALFPLHRHLFSQ------------ ---------------------V-LELI----------------------- ----xxxExxxxxxxxx--------------------------------P YDPCFLLP----LFSFILRP-----------------------ESVVDCQ KFVSSHALGVTVVALSSYDHNMRAAAYHILGSFYQHLEASCFREKKQLLY LLETVRN------------------------------------------- ---------------------GVHKSNIRVSFMHATYITKMVQQILRPEE HMYLVINRFLLRTQYVDLRRVPEFFKLFYSFDL----------------- -----------EHKLEREWVLKVLEEGMRDRLSYELCEQQSIYHTLLGFC SSPLVDQHVQ-------IQIIDVLRKTALVTNASCGLTHAHGVLTWTVQI IEK-NCV----DGRLLNAVIGLLSALWFTNMGQK-------------E-S K--MQ----WSSSAEKQQHSLx--------------------------KW LPLPIINDFLTALLSVIRHL-R---NGVKAHEMLCFLKILASVLRHxxxx xxxxxxxxx-------------LAMHPQELSCSAVLTLLQCWGTL----- ------------SQDTTLLCVLQNLANKHNIKAL-----LG--------- ----------------------------NVKEKVKGN------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxx------------------------------ -------------------------------------xxx---------- ----------------------xxxxx----xx------LVECKPLLTSV LTHWEP---------------------x---------------------- --------------------------xxxxxxxxx--------------- ------------DCTNLINATAHILLKW--------------------VL KALSE--QSYDxx-TYETLKWFQQVIVPHKVIAKSLLNDDDMRSDLLALY HQTCEYRMQKHCNS--------------------------KLETLQLFTT IMV------------------HLLEEEG-TSNV--L-------------- -----------------HTT----------------------VLKA---- ----------CLHPTND-EGAKK-E--------AR--------------- ------------LKLLSLYIHELLSRAKVPQMFLTHARLV---------- ----TRHRK-KT---------------------------QKKSR------ xPI----------------------MQIC-----------EDVLSTV--- ---x--xxx----- >ENSLOCP00000011215 -------------------------------------------------- -----MA-------------------KKRKNEDS-TESDTQEKKPKVSx- ------------------VELNGTVFKSMLKEPTKAKK------------ -------------------G------------------------------ -----------------------------------------------LET FISVAKQLPCPGLYDVVEGYIKISMDCAEILKLLEEEKRLESETALIFQG LEMILLRTASDLSHFSMAGIAIVKKIVSSFMKIICSVLHSENHRYVRQCL SLLSAMVSQGPDSAREVFSNFNFGKSLSGLARRRDKQGKPDIRLAYIQFA VSFLISGDNQTIGQVLETKDFLTDILSTGLKDDRISSINLLLSTLQTKVV QNKAISKTQKVRFFSSAVLAHIASLYKWNGIADAIPEESK--MAVDPGEA GRMVVRELTHNFLLDLCCSLNHGINFYDQSLGTAGRSGNVVLLQFIVGLK QATEDELVAELVVSILKVCPDLLQRYFKETQYSFVPRQKTAWKDNINLLK KIYEAQPEVSRAFSNEEFIPLPRLLSMVMVTSLPFICNKAFFTQGLNMG- --------------------------------------NNAVKHTTLSLV SFILKRALKNIEYCQLKTVWQNSDVYSVSMMEDFVQQYREALSKVLPDLT NIVATWQS-----------------------------LTKKE-------- -------------------------KGE---------------------- xxxxxxxxxxxxxxxxx--------------------------------- ----------------------------------FDDPETTILKAVILKV ICLYQKVVPHLISQSTFDFSKLLK-------------------------- -------------------------------GIVTEKGMREEVAPVLQYQ MLQLALDLPASKFSWFRA-------------------------------- ---------QEAVDP----G-RASGEKSVFYLLLKMFV-TSS-NTHLKTS TRMLVVKVLKDSGVFEYTWQELELWLDHLALVQQSEQETVIQFLERVLVK LVSNPYLYTDKAASLVQEASYLQANLTGQEGDAASIPVSHI--------- ---------D---------------------------------------- --DVLDMVDVIMEGSEGECEELGSALNEDLILQTFPFSALVPAALEARNR L-----------P----Axxxxx----G--------VVPEFLIAVLSDVL HSQRDPLPLCLALQQYDKELVS-AEDSTATPP---AIVEFYRYYSLWIPP QAREEL-------------------------------------------- -----------FKS---------xxx------------------------ -------------------------------------------------- -----------------------------------xxxx----------- ------------xx----------SAPGSFS-------------CLMKAA YSRGATY----------------MLQDSFKESVESAVSKLHTSDLPVAVK HVLLYIKTCVDNFG---------MFSKDTGIVLLN---------VYMDLL RTLINRLQCLEET----------xxx------------------------ -----------------------xxxNSQ--------------------- -----------------------DESDL-----------FVDVNTAQDEK -------------AEKDLVLGAVLKSIFSHPTLEQWFLAVELESLPPHNL NPIKSKKLCTQISSNILSLLKLTAQLMENLGSLDLISKYLAGIEKAVLKE Mxxxxxxx--------xxxRTNKRSHPIEGLMEFHKYMEPARLKEIVSAI LLLPQEFLVV----------A-GKHGFPEELSVYAQSALQVLTE----SS QEDS--VFVSH--------------------------------------- ---EHFRGLGTLLLSCCSEPLEIFLLKALQTEPVCSKLVQTDILIYCL-- ------Q----RLTHTCQAIGALLLQTCATHRLRFELWCLE--------P GSMKQVEKHFEAF---LPLVKVYLEMPSCQDPMRPKE------------- -------------------------------------------------- --------------------VHAAVLRDLKEALLVK-------------- ------------------------------xxxxxxxxxxxxxxxxx--- -----------------VDVLSGLIKLAAQVEDLAGAADRLS-------- ----SLLESVDSF-E------RWMLVDSITEGLAGAPQTQASWKRSLLTA SFKWLKASY-------------------------------TKYKEQ---- --------------EQAVQEKEEKMLQQL-QRLLG----SVKQVT----- -------------ASDWNSFVKTGLKYRYRD------------------- ---------------------QVFLENLNNLLVLVYEAIDSSKDLVELGT VHMMVTSHSLFLSTLLPAEEEQxGxxxFT--------------------- --------------------------------------------DALVTV LLTLVKKCPGVCSSAHFSVLMGAYGATLSTTDQKMLQLLQEYERNGVSLA EF--Q---------------------------SLLWGPAAVEHHKASRSL GSSLWQQPTSQDVLALLKPDKMLHTALHFPEQRQIIPQ------------ ---------------------DEEELLFTDKR------------------ -------------------------------I------------GDLSAL YDPCFLLP----LFSVLLKP-----------------------ECVVDCY KFVSCNAFGVTVAALSSYDPHVRAAAYQVLGQFYHHLDGARFKERRQTLY LCKNLKNxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxSIFxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -----------KHKVERHWLLGFLVEGLKDKNCYELCDRQGVFQILLSYC SNPICEESVQ-------IQILDVLQQAAHVTKAAYELIKCHGLLTWILQV LEK-RFI----ESRILSSLISLVHTLWFTNLGDK-------------E-S Rx-------VHSAADETPPKT--------------------------LKC LPLPLIDEFVRLLLAFIRHI-Q---TGSKALQLAQFLQTLSSVLTH---- ---------RSTALGTYREKGHMTLKERTLSCTEALILLHKWSTT----- ------------AKDTPILNAIHSVAHKHKVKEL-----LK--------- ----------------------------TSKERTRGK------------- ------G------------------------------------------- xx-------------------------xxxxxxxxxxxxxxxxxxxxxxx x------------------------------------------------- ---------------------------------------LPTCEQFLRSI FCSWEP----------------------xxxxx----------------- --------------------------x--xxxxxxxxxxxxxxxxxxx-- ------------DSEGLAGATAHLLVKW--------------------GL KSLVT--APLDPSDLHKFLQWIHSSVLPFPGVVGALLQDSAAKHNFLRLY HQACE-----------------xxxxxxxxxx-------------HLFTS IMT------------------RLLEAQG---------xxxxxx------- -----------------YQT----------------------TLKV---- ----------CFPDSTHxDESRR-E--------AG--------------- ------------LLLMSQYILELWTGAQEPTLFLTHVKLV---------- ----TQTKE-----xxxxxxxxxxxxxxx--------------------Q AAV----------------------FSIC-----------KEL------- ---xxxxxS----- >ENSPKIP00000017964 -------------------------------------------------- -----MSVDRLVPHSPESPLNxxxxxKKRAKKDS-GESETQQKKMKM--- -----------xTLDxxxTEFNGTVFKSMLKDPTKALK------------ -------------------G------------------------------ -----------------------------------------------LGK FVSVATKLPIADLYDVVEGYIKISMECAEIFSLLEGEKHHERELLLIFQS LEVILLRTASDLSHFSVVGITVVKKMVTNHMKLLQSSLNSENHRFVRQCL GLLSSMVSQGSDMAREVFSHFHFNKSLSKLTRRRDKKGQPDVRMAYIQFA LSFLVSGDGSTIGHVLEMQDFLTDILSTGLKEDRISIINLILSTLQTRVI WNKAISKTQKVRFFTPAILAQIASLYKWDGIADVRLEDSK--VGENPKQD GKMVVRELVHKFLIDLCCSRKHGISFYDPSFGTAGRAGNVVLLQFLVGLK QATEDELVRDLVVSILRDNPDVLSRYFKETQYSYTPRLRSTWQENVTLLK KIYEAQPEVSQAFRTREFVPLPRLLAMVTVTSLPPVCNKAFFTQALNMS- --------------------------------------NTVVKHTALSLV SFILRRAQKNIEHCLDRAVWQRSELYTAAVMEDFVQQYREALSKVLPDVN SIISNWQS-----------------------------LAKKE-------- -------------------------KCEG--------------------- ---------------------------xxx-------------------- ---------------xxxxxxxxxxxxxxxxxxxFDDPEATVLKALILRV LCLYQKVAPFLISQSSFDFSKLLK-------------------------- -------------------------------GIMSEKEVK--VPPVLQHQ ILQLALDLPANKFSWFQV-------------------------------- ---------QDVPDA----G-KAAGEKSVFYLLLKMFV-DSS-IGALKDS TRLLILKVLRDSGMFEYTWRELELWLVHLDRLPRPQQEAVVRFLETVLVR LTSSPYSYTDKAASVVQDAASLQASLGAQEGDAASIPISHI--------- ---------D---------------------------------------- --DALDMMDVMLEGAEGEVDQLGPSLTDDLILQTFPFSALVPAALETRNS L-----------PxxxxEER-------G--------VLFVYLAAVLSDVL HSQRDPLPLCLALQQYDKLL------SGSPHP---ALLAFHSYYTRWLPP QAKENL-------------------------------------------- -----------FKSxx---------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxx----- ----------------------------TFA-------------EVMKKA FCDGPDA----------------WLRSSFADSLKEALLGLGVAEFPVAAK QVLLYLKTSVETFG---------RTSxx------------xxxxCLLKVL GALVERLQAVEDTAD----------------------------------- -------------------------------------------------- --------------xxxxxxx--GESDL-----------FLETDEAARER -------------VDKDQVLLCVLQSILQHPTLQSWFLALELGSLPAHNL DPVRVKLVCRQLTEGVLALLVRCGPTLRDLGSLELMAGYLEAVRGALLRE L--------SRK----ARKTVLQASWPLKGLLALHGYMEAAGLKEVLSSL MLLPPERLLA----------S-KSEG--AELSVYGQAAVSILSE----GA GDCA--PLLSQ--------------------------------------- ---AHLRALAFLLASSPRGSIADLLLGALCREPQAAALLPGDLLLHCL-- ------D----WGDPAGLAIGMAMLRSCAAHRLRFELWCLE--------P ANLERLSGAMESF---LPLLNTYLTAASSDDPARPKG------------- -------------------------------------------------- --------------------VHTAVLRSLKAALLPG-------------- ------------------------------------------------LV ESVLSDTACDSLPAC--TEALSSLVRQTTKETELADLIHRLP-------- ----GVLERAAGC-E------RWQLVSSISDMLAGSPEQVASWRKTLLSS ALQWLSARF-------------------------------RSAKERxxxx --------------------EEAAMLLRV-QELLT----SAEQLI----- -------------LPDWNSFIKAGLKHRYSS------------------- ---------------------SAFLETLSNLLGRVYEADHVPADLLALPT LHMMITSHSLFLPSMLDEQHASxxxxxVK--------------------- --------------------------------------------ELLVSL LLTLVQKCPSVCHSSHFVVLLGAYGATLSTTDQRILLLLRQYEKNGVSLA QS--Q---------------------------CLLWGPAAVEHHKACKSL GPSLWQQPSGEGLLALLEPDRMLSTVAHFPQNRRIIPS------------ ---------------------EAKELIYREEG------------------ -------------------------------A------------GDLGRV YDPGFLLP----LFSMLLKP-----------------------ESVVNCH KFVSSHALGVTVAALSSYDAKLRAAAYQVLGSFYHHLEAGRFAGKRQLLY LMDTVRN------------------------------------------- ---------------------GIRQENLRVPFLLTTYVAKVAQQMLKPEE HMYMVINKFLLAHQDLDLKRVPAFFRFFYSFDL----------------- -----------EHKAEREWLIGVMREGMKDRHCYEVCEQQGIFQVLLGFC ASPLCDGATQ-------VLILDVLQQTAHVTKAAYELINIHGLLTWILQL IET-RCL----DGQLLCIAIDLVHRLWFTNLGKK-------------E-N R--VPGGG----------------------------------xx---AKC LPLPLIGEFLCVLMALVRHL-H---GTVKTPQLFRFLEALASILRH---- ---------RERALGVCRAAGWATACEQPLPCTAALALLHCWASL----- ------------SRDAPLRSDLQGVLERCKVKEL-----LG--------- ----------------------------IARERGRSK------------- ------Gxxxxxx------------------------------------- -------------------------------------------------- -----------------------------PRVEKAAEEEx---------- -------xxxxxxxxxxxx--------------------LSDCDPLLRDV FVH------------------xxxxx--------------------xxxx -------------------------xx----------------------- ------------xxxxLAADAARLLLRW--------------------ML RSLVA--GSADPEAVSRFLCWVQASVLRRESSVAAVLAEEAVRRDFLRLY HRACEPPPTSQDPA--------------------------RLETLRLFTD VML------------------RLLQVRG--xxxxxL-------------- -----------------HRT----------------------VLSA---- ----------CLSTAED-DASRS-E--------AG--------------- ------------LLLLSLYVRELWAGADPPGLFLCHVQLVx----xxxxx xxx-------xx----------------------------------xxTQ APV----------------------TALC-----------RQISSAA--- ----------xxxx