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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------VS----------------------TQKPQAASGPAKP---KGKDA-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KNAQGSSAPKPVP-GRRKRSSMS---------- ------------------------------------------------------------ ---------------------ASSSSPT---------------------SPKS------- -----------------A-SSTP-LSH------GQSPL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ASPAS-NSPANLGSSPTPKVIKAGKQGKAK KGDAF------------------------------------------------------V PM-------QVNYNVKMS----ENPKLM---ATGE------------------------- AKTTQIEVKAQL------------------------------------P----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PAAFKVASKPAA-------------- ------------------------AAP--------------------------ISFSDTI LSSSPKPGEL-----KKAPLA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------VFADDELPPLLPPEK PVKI-------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------VVAE KI---------------------------------------------------------- ------------------------------------------------------------ ------------------PPASDHE----------------------------------- --KTSAEAP-------------------------------ASKTSPKG------------ -------KKGNEPKSVPAEAS--------------------------------------- -----------------KPAGNEAPKNISNP----------KSTPV---------TVSQD ----------------------------------------KLAAVEAVKP---------- ------------------------------------------------------------ ----------PEKVPSMGSKQGEEVKVSLCKGMKPD------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------ENVKAAS IKTEKAVPVKIEKAA-----------------------PTKAE----------------- ------------------------------------------------------------ ------------------------KVTPVKSQETAPTKAEKVTPVKSQETTPTK------ ------------------------------------------------------------ ---------------------AEKVT----------------PVKSQETTPTKAEKVTPV KSQETAPTKAEKGTPVKSQETAPTKAEKA------------------------------- -----------------------APIKAEKVVPVKSPETAPTKAE--------------- ---------------------------------KAAPIK--------------------- --------------------AEKVVPVKSPET---------------------------- -----------------------------------------------------------A PT---------------------------------------------------------- --------KAEKAAPVKGEEATPTKAEKVVLVK----------------GEKVSTKSEKV TP------------------------------VKSVETAPIKAEKVVPVDGEKVSTKSEK ATPFKSQEAAPTKAEKVAPVKGEKVSTKSEKVTLVKSQEAAPTKAE-----KVAQVKG-- -------------EKPPTKSEVIPVKSQEA--------APVKDEKVPAKSKATPAKADKA TPVKSQGRASTVKAQEAAPTKAEKEAPAKTE----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KPTPIETAKP--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TKTDNAAP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------P------- ---------------KTEKAVEEAKTS-------------------------PQ---KPS EDSKPT------------------------------------------------------ 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------TVQEES--EEEEVDEAGVEVKDIELVMSQANVSRAKAVRALKNNNNDIVNAIME LTM--------------------------------------------- >ENSORLP00000039822 ------------------------------------------------------------ ------------------------------------------------------------ ----------------M----------------------------------------PGE ---------------ATET----------------------------------------- ------------------------------------------------------------ ---------VPI------------TEQEMQQPQ-------------------------VE TAA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------S------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PAAFKVASKPAA-------------- ------------------------AAP--------------------------ISFSDTI LSSSPKPGEL-----KKAPLA--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------VFADDELPPLLPPEK PVKI-------------------------------------------------------- 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------------------------KVTPVKSQETAPTKAEKVTPVKSQETAPTK------ ------------------------------------------------------------ ---------------------AEKVTLVKSPETAPTKAEKAAPVKGEEATPTKAEKVVPV KSPETAPTKAEKVVPV-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KSPET---------------------------- -----------------------------------------------------------A PT---------------------------------------------------------- --------KAEKPAPVKGEEATPTKAEKVVPVKSQEAAPTKAEKVVPVDGEKVSTKSEKA TPFKSQEAAPNKAEKVAPVKGEKPPTKSEVITVKSQEAAPTKVEKVVPVDGEKVSTKSEK ATPFKSQEAAPTKAEKVAP------------------------------------VKG-- -------------EKPPTKSEVITVKSQEAAPTKAENVAPVKDEKVPAKSKATPAKADKA TPVKSQGRASTVKAQEAAPTKAEKEAPAKTE----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SGSGTESDS-DD-SVPELEEQDSAQTQT--QQAQ---------LAAAAEIDEEPV SKAKQSRSEKKARKA--------------------MSKLGLRQVTGVTRVTIRKSKNILF VITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGE-ATAKIQDNTQTP--- ------TVQEES--EEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNNNDIVNAIME LTM--------------------------------------------- >ENSCVAP00000028654 ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ----------------------------------------------------------ST LSQNTPQATVPAQEMGFEEETPTPVFCDQANCIAGDQEVG--------GTHATAAVEEGS AGPAAQEEFDPIAFSRPHVATARDQRGDPFVMAEGLSTQKPTFDSVHSKASGEESDVDVV QEDGMSALHQTPLDGLMNPCKQAGGNAKY------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------PD---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----AGSGTESDS-DD-SVPELEEQDSAQTQT--QQAQ---------LAAAAEIDEEPV 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --VAAPAEEAQSQESIVAA----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------AAELVFQVVKQASYEANAPGDEPE----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------AIPEKILDGKTPSASEGVTVNT EDVMATDSPMLEVEDQKNLET--------------------------------------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SGSGTESDS-DD-SVPELEEQDSAQTQT--QQAQ---------LAAAAEIDEEPV SKAKQSRSEKKARKA--------------------MSKLGLRQVTGVTRVTIRKSKNILF VITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGE-AVSNIQENTQTP--- ------TVQEES--EEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNNNDIVNAIME LTM--------------------------------------------- >ENSHCOP00000015546 ------------------------------------------------------------ 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PVPDPTSCK-LTLDEALAKPTPVQSEVELLN----------------------------- -----------------------SLASLKTA----------------------------- -------------------------------------PTSDKTP---------------- ------------------------------------------------------------ ------------------------AQVETV-IK--------------------------- ---NDAGSGTESES-DD-SVPELEEQDSAQTQT--QQAQ---------VAAAAELDEEPV SKAKQSRSEKKARKA--------------------MSKLGLRQVTGVTRVTIRKSKNILF VITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGE-AVSNIQENTQTP--- ------TVQEES--EEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNNNDIVNAIME LTM--------------------------------------------- >ENSDCDP00000031918 ------------------------------------------------------------ ------------------------------------------------------------ ----------------M----------------------------------------PGE ---------------ATET----------------------------------------- ------------------------------------------------------------ ---------VPV------------TEQEMQQPQ-------------------------VE 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------------------------------TEAPV-SG---KGDQLAPKVVKA-KQGKAK KAEAF------------------------------------------------------K PA--------------------EQPGLQPVSATAE------------------------- AEVTKTPA-------------------------APAE-----------PEKAEVVKESAP IAKPAAA----------------------------------------------------- -----PVP---------------------------------------------------- ------KP---------------------------------------------------- --------------VSAPVTV--------------PLAAEPKNVKVGSP----VTKETVA PEKQVPPSVGVSKTSVAPKATEKSAVVEANSPKTAPPSSNATN----------------- ----------KPVAPP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------PADAASPKAETP------------------------------- ------------------------------------------------------------ ---------------SVASKDT-------------------------------------- --PKPVAS---------P------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PIE------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PVSPKITAAPAVPKAAP------GPV APAVVEAASPKLTTVPVPTPKQTLPSP--------------------------KSFAEAV ACSPPK-----------------VQPE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ 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--NKPA------------------------------------------------------ ------------------PG----------------------EAFKPPAQDKPAKDVPPA TIEAINAVPASKPASTEA----RPPLNQNAKPVANKSAKQIDDTKVDIVKPGTEVKAATD VKPAAGPKQ---------------------AAAEVTKPALVMGSKPETKAKLLEAKAEPP VAS--------------------------------------------------------- ------------------------------------------------------------ --------------------------KP-------------SPA---------------- ------PIEPA------------------------------------------------- ------------------------------------------------------------ -VPAPAPRK-LTFAEAVAKPAPVKPEVESINTT------------------------P-- ---------------------PEPVSSPKPA----------------------------- -------------------------------------PAPVKTP---------------- ------------------------------------------------------------ ------------------------TKAEPV-I---------------------------- ---NNEGSGTESDS-DE-SVPELEEQDS--TQT--QQAQ---------LAAAAEIDEEPV SKAKQSRSEKKARKA--------------------MSKLGLRQVTGVTRVTIRKSKNILF VITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVPGE-TVSNIQENTQTP--- ------TVQEES--EEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNNNDIVNAIME LTM--------------------------------------------- >ENSPKIP00000039126 ------------------------------------------------------------ ------------------------------------------------------------ ----------------M----------------------------------------PSE ---------------ATET----------------------------------------- ------------------------------------------------------------ ---------VPT------------PEQEMQQPQ-------------------------AE TVL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------AA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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-----------AAATGEKSAT-------------TADSKKLSSASAVSTP---KAKEA-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------KSGS-------KQSSHSSSVSKPMP-VTSKPSSSF---------- ------------------------------------------------------------ ---------------------ASDSSPS---------------------SPKL------- -----------------SSSDAPEVSPPALSTAMPSPLV------------------PPT ------------------------------------------------------------ --------------------------GSP------------------------------- ------------------------------ASGTG------TASIPQPKVIKTSGKGKAK GGTVL-----------------------------GAKAEKPIGKAQLTGPANVILPTSQA PAAM-------------------------------------------------------- ------------------------------------------------PE---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EVQASL---------------------------------------- ------------------------------------------------------------ -----------------------------------------------PASVKPAKIDIPT P--ASVKPA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------KIDIPTPASVK--------------- ---------------PAKIDI--------------------------------------- -------------------------------------------------------PTP-- -------------------------------AS--------------------------- ---------------------------------GPAVDKISSPISG-------------- ------------------------SAPAPISNLPVACQSLENSPSVAQSLSTSVSKSDPL LSS-------------------KSAADPVAVEV-------TPQAPTLAPT-------LAP TL------APT------------------------------------------------- ----------------------------------------------------------LA PT--LAPTQAPVDTKALGVPKATSET-------------------QRVE------PEL-- SPRADTANSKECQAVPGDLPSS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------RKPPEATP-VMAMPLPASDAVPVP------ -----------------------------------PATD-----KSPKPSLSSSDAEKTQ SASVLPPPSASANLPVPS---------------AKSYVQPRVLLAPEEDDDLPPLIPPEE KITLPT------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PPV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VP--------------------------------- ------------------------------------------------------------ ------------------------------------------------ISF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------H-----------------------------K-- --------P-------------------------------------------P------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PA T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TKLEPV-IK--------------------------- ---NEKGSGTESDS-DE-SVPDLEEADSAQVQS--QQAQ---------LAAAAEIDEEPV SKAKQSRSEKKARKA--------------------MSKLGLRQVTGVTRVTIRKSKNILF VITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGE-AVSNIQENTQTP--- ------TVQEES--EEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNNNDIVNAIME LTM--------------------------------------------- >ENSIPUP00000017687 ------------------------------------------------------------ ------------------------------------------------------------ ----------------M----------------------------------------PGE ---------------ATET----------------------------------------- ------------------------------------------------------------ ---------VPV------------TEQEMQHPQ-------------------------VE TAA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------VA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------SV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AG--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------SQP---KAKGA-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------KA----------DSSPHTSAPKPVPVGRRKRSSLS---------- ------------------------------------------------------------ ---------------------ASSSSPI---------------------SPKSA------ -----SG-------PRATP---P-CSP------LASPS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ARSPG------AGKHETPKVVKAGKQAKSK KAD-F------------------------------------------------------- ------------------------------------------------------------ ----------------KVAE----------------------------PQ---------- ------------------------------------------------------------ -------------------QVTLPFAAPSE------AKTAH--------KSSPTSAKVAT LPVEG------------------------------------------------------- -------AATASV----------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------CPK AAGVAPPEAKPVNDES---VTLAPAEAKLVKGAGPAAASPQCTTTSQVKAKQVKGAAD-- --------VPVKTEAPAKD-VPAPVEAK-----PVNDESVTLAPAEAKLVKGAGPAAASP QCTTASQVKAK----------------------------QVKGAAAAP--------VKAE ----------------------APAKDVPAPVEAKPEK---------------------- ------------VEATTSTSDG----------------------------VKPSKDAGPA A--ASPKGTIAAPRKAKEEKGAAAS----------------------------------- --PVKAEA---------P------------------------------------------ ---------------------ALSKDVVPATV---------------------------- -----------------------------------------------EAKSVK------- -------------------------GEV-------------------------------- ------------------------------------------AAMTP------------- VDVVKGAAPPLAKDV-AK------------------------------------------ ---------------------------------------ISVEAKPV------------- ---------KSEASALTPVDVMQVKGAASAPASVKD--VAPVEAK--------------- ---------------PVK------------------------------------------ ----------GDAAAPTPTPVDVMQVKGVASASGTSQVTLPATV--IAKPLEGVAPTP-- -------------------------------VSPK------------------------- -------------------ATVS-----------PDAFKVVSKSAA-------------- ------------------------HAP--------------------------KSYSEAV AFCPPK-----------------V-PD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------MPKVVHEAPVVPKGAEVPKVSAIVPETPKV------------ --------TEVPK-VSAIVPETPK------------------------------------ ----------------VTEVPKA-SAIVPETPKIAEVPKAAPESPK-------------- -----------AQSVPA------------------------------------------- ------LSPVQKA--KSAPVAASKENAEARKKKPSVGP---------------------- ---------------------SNVMAATPLQSSISP------------------------ ---------------------------------------------LEEEDDLPPLIPPEK PSTMPVFQP--------------------------------------------------- ----------------QP--------------------VVEA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PPKV-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------EPL---------------------------------- ------------------VKAIVP------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------TP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------AK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------TQPE----------------------------- -------------------------------------PTPVKVA---------------- ------------------------------------------------------------ ------------------------SKPEPV-IK--------------------------- ---NDKGSGTESDS-DE-SVPELEEQDS--TQT--QQAQ---------LAAAAEIDEEPV SKAKQSRSEKKARKA--------------------MSKLGLRQVTGVTRVTIRKSKNILF VITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGE-AASNIQESTQTP--- ------TVHEES--EEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNNNDIVNAIME LTM--------------------------------------------- >ENSXETP00000054220 ------------------------------------------------------------ ------------------------------------------------------------ ----------------M----------------------------------------PGE ---------------ATET----------------------------------------- ------------------------------------------------------------ ---------VPA------------AEQELHQPQ-------------------------AE TAP--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SPSA---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P------------GAEA A----------------------------------------------------------- --------AP-------------------------------------------------- -----------------------------------TEGAV-------------------- ------------------------------------------------------------ ------------------------------------------------AAEAKKTVTPNA KVASE------------------------------------------------------- ----------------------------ASQTDAAKAEA--------------------- ---------------------------------AGDSSDSKQGVTKKKSSE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------PSKPGKVKGKSSEH ------------------------------------------------------------ --------------------SLKS----------------------RE------------ --RKVSESSPKHGKAKA----------------SEPSPKP-AEAKASEPSPK----PAE- ------------------------------------------------------------ -------------------AKASESSPKHGKAKASEPSPKPAEAKASEPSPKPA------ -----E-----------AKASEP--SP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------KHGKAK ASE---PSPKPAEAKSSEPSPKPAEAKSSEPSP--------------------------K PAEAKSSE--------------------PSPKPAE------------------------- AKSSE----------------------PS-------------------PKPAE-AKSSEP SPKPAEAKSSEPSPKHGKAKASEPSPKPAEAKSSE------------------PSPKPAE GKSSEPSPKPAEAKSSE------PSPKPAE------AKSSEPSPKPAEAKASEPSPKLAK APEPSLKP---------------------------------------------------- ----------AEV------------------KAPEP------------------------ ------------------------------------------------------------ ---------------------------------------------------------SPK PAEVKAPEPSP-----------KPAE---VKAPEPSP-----------KPAKVKASEP-- --------RPKPAEAKASEPSPKPAEAKASEPSP--------RPAEAK------ASEPSP --------KPA----------------------------EAKASEPSP--------KPAE AKASEP---------------------SPKPAEAK----ASEPSP--------------- ----------KPAEAKAS------EPS-------------------------------PK P--AEAKASEPSPKPA-EAKASEPS----------------------------------- --PKPAEAKASEPSP-KP------------------------------------------ ---------------------AEAKASEPS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------P------------- ------------------------------------------------------------ --------------------------------------------KPA------------- ---------EAKASEPSP---------------------KPAEAK--------------- ------------ASEPSP------------------------------------------ ----------KPAKAPEPSP----------------------------KPAEAKAPEPSP KTADVKVSKAVPKLGEK--KERAA------GASPK------------------------- -------------------PSSA-----------P--------------SPTDSTSQG-- ------------------------AAPESISSAAVA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------AP------------------------------------------------- ------------------------------------------------------------ -----------------------------------SLPVAEVQSPANKSEGLSPQPAAEL SAQSPAKVLTPSQSLPT------------------------------------------- ------PEPVSSA-------------------QPD------SVSPPL-----AP------ ------------------KTSSTVLPSAPL-----P------------------------ --------------------------------------------LTVEEDEMPPLIPPE- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ -------------------------AP-----P--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------QE------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------HAFH----------------------------- ----------------------------------------------------PV------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MVD----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------FGSPKVVQTP---------------- ------------------------------------------------------------ ------------------------PVKEAV-LK--------------------------- ---NDKGSGTESDS-DD-SPPEL-EQDSTQTTT--QQAQ---------LAAAAEIDEEPV SKAKQSRSEKKARKA--------------------MSKLGLRQVTGVTRVTIRKSKNILF VITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGE-AVSNIQENTQTP--- ------TVQEES--EEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIME LTM--------------------------------------------- >ENSSFOP00015005103 ------------------------------------------------------------ ------------------------------------------------------------ ----------------M----------------------------------------PGE ---------------ATEA----------------------------------------- ------------------------------------------------------------ ---------VPA------------TEQEMQQAQ-------------------------AE TAS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --GDLNTSKSQAISV--------------------------------------------- --------------------------------HEAAQGVSGENLSMAAEVAGMSESC--- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GMP---------------- -------ESVLESTGLSV--------------IGHDSEDLKLEFASKISAGKQNGDVISK --------VP-------------GQVEVLVLPGVAEAVDINAQQHVDPKEEPAVNELGIA VEVTSSVRAENPTVVKELAVCGKQELEG-------------EEQVISAEQESAAEETEMV AEERVP----------DVVDACSLECCTEDNKLVGELEAV-QDPCITEKLLPASENVPSV EPAEETKGAEPQSVFHEQTCTEHVVSDVVVEKSGSSAEDAK------------------- ------ALEGLSPVQEPATIEQPVLDVVDALSGEIPAEEAKPAEALSATQKSATTEQQTM DSVHLPSVESLKEQQTKVPDNVQAPPG-------------------ESLVEERAKAAGKQ SDEEPTVYEQPVTDVVDVSSGDSPAEEQA------------------------KSVKALL GQEPMASAQLLPDVV-----------------DAPSGESPKEQTRAPEKQLPVQKPAAFE QSVLDIVDATSAKLSVECMAAVEAVGVPENTGGQKHESQEPSASIPLAADDVDDPVGTIP VGLASENSCIIQVAESSMPVGHSDRLANENMIPENPQQACGKNEYDKNEGMGSLTATAT- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------EVAMPTINFTI TIPNEVATQSGDL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------VTALSEAVQTELASSWPGQPV AAQKASAPAPPAAVAAEKKPAPPASKKNSSTPPRSA------AASTVTMP---KAKEA-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------KSGSK------LSTSPLSSTSKPVP-VTTKCSSSS---------- ------------------------------------------------------------ ---------------------ASASSPT---------------------SPKVS------ -----STSPSVSSLPCSTP---P-SSP------LAPPQV--------------------- ------------------------------------------------------------ --------------------------GSLV------------------------------ ---------------------------------PG----EGDASVTQPKIVKAGGKGKSK KG----P----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------PS---------- ------------------------------------------------------------ -----------AVANAQ------LSAKAAQLPDKTGAQVTEAIPNKEGTEALNTDASMAK AA----VP---------------------------------------------------- --------------VTVP--------------GPDPVSV--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------P------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------PE------------ ------------------------------------------------------------ ---------------------------------------ISITASPP------------- ---------KSDLS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------LSPK------------------------- -------------------NVDA-----------PVAFKVTSQPAV-------------- ------------------------PAP--------------------------KSFADAV ASNLPK-----------------IAPE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------TSK-----------------------LEKVAVSTEEVKE--- ------------------------------------------------------------ --------------------PKAISAELPLKKPPKEVPGIANSPPV-------------- -----------SASTPD------------------------------------------- ------------------------------------------------------------ ---------------------------------ISPATHPSSIAKKSKISIASSDGKKVP SSTAQPSVSPSAPTPTPTPTVVTPSPEVASEVAASS---P----ALEEDDELPPLIPPEG FVGMPVLQPPT------------------------------------------------- --------------------------------------LVEVST---------------- ----------K-----------------------------------------PS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------PPV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ---------------------------------------QAAAVST----------LK-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------PAKSP---------------- ------------------------------------------------------------ ------------------------AKLEPV-IK--------------------------- ---NDKGSGTESDS-DE-SVPELEEPDSA--QS--QQAQ---------LAAAAEIDEEPV SKAKQSRSEKKARKA--------------------MSKLGLRQVTGVTRVTIRKSKNILF VITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGE-TVSNIQENTQTP--- ------TVQEES--EEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNNNDIVNAIME LTM--------------------------------------------- >ENSGAGP00000012927 ------------------------------------------------------------ ------------------------------------------------------------ ----------------M----------------------------------------PGE ---------------SAKAEGALLRMDPGGLRPAEADGSQNASSTSTPSGDSSPPSTLTP LQVSLTAAPDCTSPTAMEPTLCSP---------------------------------GAL A-------FLPA------------KKEDRPQPEG----------------------ASCD TAV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------GSSPTG---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSECSQV---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------LLETP------------------P----KGL--------- -------QEV-----LSVDMLDTRIVMGEETQCSDDKPDTGVELHSSL------------ --LDDK--AP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --VSE------------------------------------------------------- ----------------------------AAGAESLAAYA--------------------- ---------------------------------GEESSDEENWILESSSEA--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------VGKLS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------AQATPGESPC----------------------------P---KPRDNRQ VCLYRPPRLLP------------------------------------------------- --WEPEE------------PSMAL----------------------KE------------ --KLFSQ-----GETMADV--------------PSPSPTP-----------------AKD PPDELAEAGPLQPPQVKPVLDPDLYFTAPSTPIKTV--YSHLK---------------HL PYAKDHLSEEQSDMDNEGLC----SPPT---------------------SPSGSYITAEG GSWASSG----------TSSTSPSCSP--------------------------------- ------------------------------NLIAESETVE-------------------- ------------------------------------------------------------ ------------------------------ASTAY------------------------- -GESL-----------------------------------------------LELELSEE PA--------------------------------------------------------LF ARSS-----------------------------------------CLSPEQLE------- ----------------------------------EEEEGDQSLERLSSGNMTLPS----- ------------------------------------------------------------ ------VPVE-------------------------------------EEGDGQTTPEEE- -WDSEIATSIAWV----------------------PLTTEPED----------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------PGE---------------------------------- -----------------------------------------LLPAEEK------------ -------------------------------------D----------------L----- ------------------------------------------PHPGGDSGDEPLQSILDR QLLKVEVFTSDKASASLGTGDAAKEPLESSLVSCS-----------------------PI PL----------PGLQSESSSVSGA-----SCSSDA-----ET----------------- --PSSLQAETTGSSAELP------------------------------------------ --------SDFTDNDQMI----------PATLL--PFRGSLIFEAESLEITLFP------ -----------------------------------------------QGESVE------- -------------------------NDVVYG----AEEDDS----------TSASFLHSL SENSINEGVDESFAYQDDTSQSSDSASYNGEADEQLYSTEQYAVVTPSAQEGE------- ------------------------------------------------------------ --------------------------------------------KPA---AEDSEQGASC SGSESEMETSSDAS--------------------------------DTDEEYTAFSALGT VPHTGVEVGFV----P---------------------------EGNVAHQDKLEGSTEEE E----------------------------------------------------------- --------------GEE--EER-------------------------------------- --------------------------Q-------PPA-----------------QSEGML KS----------------------AAP-------------------AE------------ ----PK-----------------------AVLVDEHSDSDSPGSGSISPTGQGWSLSLKP DS------TPSPGESALRAKSDQAD-SPGDTGSSSESSLEHQSSLSDMQEALEKGLPN-S GECLIACFDTDEETEVFPGLEVVMENAELISQSAEVCVAPWRGGDGMGSAIPLPWKQKPA PTELAEPTARDASVFEMGTKLKESET---------------------------------- -------------------------HLLELLDQDSTSLGGKREDH--------------- -----FVAQLGASDGASLEQPEV------------------------------------- ---------TRADSEPA------GECLIACFSSSEEELEEASSLDQVNNNEEQGELFLEA -SLDS-----------------------------------------------VPL----L GQNDTQ-------PNMLVDTAS----------QNEP------------------------ ------------------------------------------TLAVVVDQQQEPLLPP-- ------------------GDSESQSLDLHTMQRDLQELQRTLDGSRQQECRELDA---SS ESERET-------------------------YV--------------------------- ----------KR------------------------------YFGTTAFSLLPQAIVVPE ST---------------------------------------------------------- ------------------------------------------------------------ ------------------EPTWGQEALGKKPALADSSIPEPIWPCSGTGETKDSNSKEPQ LDKSSPASPGIQLLGEMNSSTDQNQEELMASAEEKWLTAEAAESDLES------------ -------TFGASPVAAMGETQ--------------------------------------- -------------PKA----AVQALESLGEPVEMV--------TPV-----PCSSTVSHD LQT---RSAEEATYASVSGSESCSQTDSVSAQVCPLGDQLEMETPTAAAP---------- ----------------------------------------------------GQTLPEPG AQVF--------QAPHVCS-------------LDPDLPE----LRDSNMNVLETASSE-- ------------------------------------------------------------ --------------------------------SPWEPEHGAGED---QDSSVSTSSSKNV VL------EGEMESTNAEETAKKTIGDQLGCDELPGGKGASTQEQWLGSTQLPQEVKPAA LQQSESLGDVTEEEALGSEATSEEGVYLTDEEREAEAQPEESQPGTPSPKGEMEVELAES AEAASEGSSSAFSNDLSS-----GDSP---------------------EG---------- -------RQTPGCAALRPPLALDDKMTTVDSTQEEPDKA-----VSSRESSPEPPDTT-- --QSFMHMDSSFFMAS-------------------------------------------- -EESMG---------ESTRLVEQKSS--------RAGGELGAPEQAESQLTEQQEGDIPT ELKEA------------------------------------------------------- --------VLPPEYLHVGISSRDSPS---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LPEPS PSG--VSSAE--------------------------------HSLA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------PEPSEHSLA-------------------------- ------------------------------------------------------------ ------------------------PEP--------------------------------- ------------PEHSLALC--LHYS----------SLQAAPRSTHSECTRLRSNVPVPS N-QQLLFTASEKIIYIGE------------PAIHGQ------------------------ ------------------------------------------------------------ ---------------------PPAEPGDSSP----------------------------- --------------------------SASLEAEHSAEYSGPTKTSPDLLESKAVIAESLA ISLGLHEPSGALV----ENPA--------------------------------------- ------------------DP------------------PAASREWQQITAMLQGSFGNLQ -----ASQL--------------KVGP---LCP--------------------------V SSQMVT--------------EAQSVLASLKERVL-------------------ESSSGE- ----------ATPDSLE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------A----------------------------------SEAQKRVIKAQP E-----PETPT------------------------------------------------- ------------------------------------------------------------ ---------------------------H-----------ELTAGSASRQPSEDQGARQ-- --------PS-EDESTSEQAQLESICETLLAAEVTPSPVLLASSMGSSESVTPVL----E EQDLSA-EEDSS--LHSEGPLEEESIQTSSGTHAKDQDQRSLSL---------------- --EEPAELGI----------------------------SP-------------------- ----------RVEEPWESPG----------------------EA---------------- ------GVDGAMPEASQAGHLQSPQL---------------------------------- --PANGGNQQSQIPLGDTESSREN---ETLSTTEATSPLILHS----------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SPSPEPSAASLASDFQPP-------------ESP ------PPEPC------------------------------------------------- ------------------------------------------------------------ PIPAAAPLQ---------SRQPASPEVTV-------------------------EDAP-- --------------------SPPPCS------ELIEVPPALSFLPPCSEDPIQGQNSGLP ASEALSVTED-ACTEDQPSLLLDSRKY-LEALESSASPVPCRDPFL-S-------TQDSR GRPQLP------------GNKDTRGRGSASAEERQAHRGFVQLESS-------------- ----------------------SSSESEPP-YRCPEIETLREAAGMTLLED-KPLVGQRS CEVNHKGSCNDSESNDE-SIPELEEPDISEPRTAQTQAQ---------LTHSLSTGEETI SKAKQSRSEKKARKA--------------------MSKLGLRQIHGVTRITIRKSKNILF VITKPDVFKSPASDIYIVFGEAKIEDLSQQVHKAAAEKFKVPME-HSPLITETAPAL--- ------TIKEES-EEEEEVDETGLEVRDIELVMAQANVSRPKAVRALRHNNNDIVNAIME LTM--------------------------------------------- >ENSPVIP00000028054 ------------------------------------------------------------ ------------------------------------------------------------ ----------------MGAVLNRLQLRAERDGSRSNSPASTPSSDALTPLQFSPAVTPDF ---------------QAET----------------------------------------- ---------------SVDPTLCSK---------------------------------NML A-------FRPT------------KKEDRPQPEG----------------------ASCD MAV--------------------------------------------------------- --------------SNATACL--------------------------------------- ------------------------------------------------------------ ---------------------------------------------------VA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LSECGQV---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------RVEEEEA----------------P---------------- ------------------------------------------------------------ --------QP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------SKAA----------------------------SKGPGEP---PGEDM-- ---------LETRIVMGEETQCLSEEEEEAEEAGQQAKADVLTIGLGAEEEEEEEGTTGQ VLWGAEELLVEPSPPAARDPSIILSLPDLQKHKEPEALVAPAPAAGSP------------ --SSISQ-----GELRADVPFPLPVISKDIPSESAPLQIP-------------------- --------------FGG--LDSELYFTAPSTPIRVG--FSPLR-------PLPPHAQQHL PLSKEGSGEEHHDMDAEGLG----SPPT---------------------SPSGSYMTAEG GSWASSG----------TASTSPSCSP--------------------------------- ------------------------------NLMAESEAME--------------EAAEG- AGELAE--------------------GAPP---------RPP------------------ ------------------------------AAAPG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------LSPELGR------- ----------------------------------EVT----------------------- ------------------FQTL-------------------------------------- ------SP-------------------------HGVHASFVADEEGEDDDEGQTTPEEDD PWDPDMA---ALV----------------------PPKLEPVK----------------- ------------------------------------------------------------ ----------------------LSWTESGEESEEDEDRLTSGPSG--------------- ---------RPV----------IPSK---------------------------------- -----------------------------------------SLPPDEA------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GAREPAKPSAWPCSF-DAS----------------SGPL P-------------------------------ATEA----------------------PD --P---RAEMVASS---P-------------------DDG-------------------- --------VENAENDPMI----------SALLL--PFRGSLLFEAESLEITLFP------ -----------------------------------------------QGEAVG------- -------------------------NDVLYSEEEEEEEEDS----------TSASFLHSL SEASIHEGVDESFAYRDDTSQSSDSASYNGEEDERRYSVEQYAVVSKAAHE--------- ------------------------------------------------------------ ------------------------------------------EAAPT---KEE-----PC SGSESEMETSSEPY--------------------------------NSEDDEASLVA--- ------------CREPQE------------------------------------GEGEAE ERGSFQGGD------------------------------------------------PR- --------------GEEVPQEKEAAHGPMEVATPTV------------------------ -------------------------LQTEPLLRGP------------GDSP--------- -----ERSGRRS------------TSP------SLQCQR--------------------- --SPPEQEETSAA----------------------------------------------- ----------VPALLGSRARSEEEEGSPGGRGSHSASP--EPEPLSENEEAPEEGPPDLA GECLIACFDTDEESDPLPPLEESPGEPQPVGQMAKEWVVP----GGPGAAIPLGWESELY PVELAVREANDPAAFDIGAKLKESEE---------------------------------- -------------------------QLLELLDQDE-ALGEEEEDPVEPGGPNGGGLDAEP KKEALFASLLEVSEVGSLEQPEV------------------------------------- ---------IRADSEPA------EECLIACF-DSEDELEEAASLDHMNNNDHAVVMFLEA -ETDS-----------------------------------------------QPL----T GLNDT------------------------------P------------------------ -----------------------------EDVFVAAH-------------DLPLEAPPPG PT------PP----------------------------------------------P-HT EAE-------------EP-----------------------------------------P EDHRWSLCGRQRGLERGPHVGHLPCEEGAQGDDPTTQV--------------PT------ ----DAQ-----------DASVGV-----------------------AQPG--------- ----------------------E--------------LP--------------------- ------------------PPI-------------------------GMG----------- --SCAVGPP-------------------------------AEETFENG------------ -------KETSEP-------------------LGE------------NVCAAEDR----- -PEAAAEELE-EHPQE-LPAEDEA--------------GQNWGTPSEE-----EEEAAED DTASALESGECRRAASVEGD-------------APLRDPLEAEHPARDDA---------- ----------------------------------------------------GGL--ESG AGVVQDVTD-----------------------ARPSAPECPPVVTDNNMNLVQVESEEMI CVPVVSGMGSETHL--VADASEKAGPSEGDSDPGVPMAMEV----TGQISSRVPVVGGMG VVAPRAATEDVELFYQQSSEVQSEGVRLEPAASPPSPDDRQPLDTKAQGDEVSSETAENV NATSSLEREGDVSCRPAQQAHKKTFAEALLQGLLP------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VSRAEVTFQGEDLE-----ASSSSSSSEPPDVS-- --PSQSLTDSSFFTAAE---------------GSSMETVVLTASPDSKREALK------T PEEMWG---------SPARVVEERPS--------------------------------PQ EQQAA------------------------------------------------------- --------ASEPE----------------------------------------------- ------------------------------------------------------------ ----------------------------------------DGK----------------- --------------------------------------------------------AEPV PVSLEVSSAE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------G-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------PSP--------------------------------- --------Q------TLAVC--LHHT----------ALAQTSSSAASRRSKTQRDPPTMS NDNQQVFFASEEEIYLTE------------PK---------------DALSSRTGDMGGA EAAGH------------------------------------------------------- ---------------------PQAVDVDTA------------------------------ -----------------------------------------------LVDSETVVLESGP -----------------ATPCPLE------------------------------------ -------------------P----PGALLQSDAAVAELPDRVADQQQITSMLRGSFGNLK EQRAGAVRL--------------------------------------------------M SSQLVA--------------EAQSLLGSLKGSAV-------------------ENSSGE- ----------LTPEWSE------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------A--------------------------KD------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------SGEEPLSSQGSSDAA ADRDRDTLPA-REEETGRDDLGKERPETLLEAEGVP---------------NP------- ----SE-VEDTL--------------------------------------LNRLATSRPG GDEQPHE-GLILMPDEGQGEEAEVAERRPCQQEELPFQSPEADVVAEEGIREIQDEVGSR ALVEEQPGHLRVEEEEEAQA----------------------EQ---------------- ------TASHGFTEVTKDSALETDFL---------------------------------- --PTDAALPWPRAPLGTTTTALESLAAPVLQTEAPGSPVVEET----------------- ------------------------------------------------------------ -------------------------------------------PV--------------- --------------------------SP--PPSPSPEPQEVPPP-------------ATP ------PLPPS-----EGHL---------------------------------------- ------------------------------------------------------------ PGPAAAPWL--------------------------------------------------- ---------------------------PAPA----------------------------- ---AVGFGEEHAPSKDTPCHLQDSRNLPVEGLEKSRPPGPCQPDLLPS-------SKDAR GRNRLP------------GNKDVRGKASASAVERRADRGSLQLESSSSGER--------- --------------------DLS--------YRCPEMESLKEATGVMLLEEKKPLVGKRG HEANHKGSSNDSES-NEGSIPELEEPEVSEPRTAQSQAQ---------LTHSLGTGEESI SKAKQSRSEKKARKA--------------------MSKLGLRQIHGVTRITIRKSKNILF VITKPDVFKSPASDIYIVFGEAKIEDLSQQVHKAAAEKFKVPME-HSPLITETAPTL--- ------TIKEES-EEEEEVDETGLELRDIELVMAQANVSRPKAVRALRHNNNDIVNAIME LTM--------------------------------------------- >ENSMAMP00000016530 ------------------------------------------------------------ ------------------------------------------------------------ ----------------M----------------------------------------PGE SAHRSVPADKHPEQGAEET----------GL-PG-PDMTRHPSTDSTPSYSGSSPS---- ---DSGSSPYPSTPQKLLPACTSPFGPRIFHATPSPSGTPRPQPEGSDHRNNTPRLSGKL GGHGPCGRYVPVKMERIKVLTGSEVESDYQEPQTIDIRVVMGQETLLKTSENQKRKLLVE SSDQAV------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ --LSD---IP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------SF--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------STP-QAQAKET-- --------QLET---------C----------------------------KEEDQGQTSP KLQDHQK-----------DPVQATTTPSIPLHNSP----FTASSSSEPITTDDNLIDSQE ESETLSQDE-----------------------------VP-------SLSFSELPCPVAL SFSEPAYAVDPLRVGVPSSLDPDLYYTAPSTPIKMISRSSHLKHHSYPGSPVYP------ ---------------------LSPGSPS-----DSEDLCSPLT------SPSGSYITAEG GSWASSY----------ASSTSPSTSP--------------------------------- ------------------------------NLLLTEEAQE-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A PA----------------------------------CFVGSLSEIGDE------DGE--- ------------------------------------------EKGRVGPE---------- --------------------------------REEEKAGDFCLY---------------- ------------------------------------------------------------ ------CP-----------------------------EDFVTNSQ--------------- --------------VDIIGTVILEDEK--------PLKGEETKILRESCQTCWVTEDT-- ------------------------------------------------------------ ---------------------SLLRSSSSRSSDSQEDGGES------------------- --------------ES-------------------------------------------- ----------------------------------------SLCPLEEA------------ -----SARRAEYSRHMQTGLKLQLEACISEEHYGRMDD----------------L----- --------------------------------------------P--------------- ----------------------------------------------------------DL P-------------------------------STAL---------------------TPD T-----ENMTMASSSLSP-------------------DSPLTPLGAFCPVAFERLGLSSF MTSQTACVDDIPEEERMI----------PASLISFPLHTNLIFKADSMEITLFPTEEENE IINDRNERKDVDAYAAGEEEADVEDDDEDDDEEYDYYDYDDDSDGNANGAVVGAAAENNE GDDSDDHDGTGEEAKVEVKVVEEEEEEVVEEQEEDEEECDSKAGEDPTDEDSSASFLHSL SDTSINEGLDESFCFQDDTDDSLDSASYNGEEDEHLYSTERHA-------QSLE------ ---------PTSVDVLEK------------------------------------------ ---------------------------------------TEIQAGPE--------QGSAT GTSQTE----------------------------------PLHIQ-LNTVDHSKAMC--- ------------VSEPISEAIAPHATGNTIHVEPKTLEAPKTPETQTNHE--LESTSE-- ----------------------ISQAKSLLTQVGTYQQKLPCTLEFI------------- ------------------------------------------------------------ ------------------------SCQ-------PESF---------------------- ---INIESGSESEVMDISGY----STP------------------VEQ------------ ----PK---------------------------------DTP---SINPSTTPADIYFSP ESEVDLPGSPTPGKT--------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------TKDTPDLNS SGRPEVMMEKNPQRKDGDVKQSND-YL-------------EEEKPER----DSFKLLIKP RHY----------------QPES---------------------------------HRTV GATRLALSKSFSNNAPGGAEAM-------CRSSAHREFD--IELDQKNGNAPDECMNVEC RRTDS-----------------------------------------------GPYGNMAT ATNDLNKGVLFLSC---------------------P--------KD-------------- --------------------------------------------------------PSPN PSNIPVSVSP-------------------------------------------------- ----EVISELSDNLVLTP----------------EHC----------------PSDSI-Q ENLRENT---------------LSTDEGVLGAVGSPQSP---------FAISPKR----E NSETDAGREMGPGAGAWCDDSVGLGLGLGSVS--------------EAEFGVWGAGESFS LSLGKRYELEA-----------E------------SLLT-------CDTEGQSTQTV--- ----------------IVPKMSSEV-------------------------YKNCNN---- ------------LLGS-------------------------------------------- -------------------------------VLDE--------EDNNSLCGKTDQMVNEV VEEGASESNL-NHCKS-IEGISEA--------------GE-----------------GED GSSRFPEDDVSNLNQSNNGD---------------------------------------- -----MQMQDIWKKNNDSVFDSLKVGTCGGLNALSEEVRHQSITVSVRESV--------- ----------------------------------------------SNIPLEEMPAQVLD TIPDEEQEPTDSYMNQISDTTQRTSANKGMCSISVPLAADTDPTNTDEAEPRCHSNPKCQ TITPGNNTAFSLLHGSFGSFT-------------PKCKDQEPRPCRSL-----QEKAENI VFLSEM-------VVPQTECHKRC------------------------------------ ------------------------------------------------------------ --------------NISSVIERLDDEPKTNDAFKGQRCVVCNSEEEYEEGKVEEEENERG ENKRKNKRE-----------------------------------RKASSVQNSPEDIACH TEKGELCTDKQF--AAKKGRRGRQNKNRTTQAGNHFD-----SSPESTDDPVKPSVPLNT TEAGWSKKIANNSKTKPSLKVNNKAS---------------------------------- -------------------------------------SSDYQERTS-------------- -------GTDKAE----------------------------------------------- ------------------------------------------------------------ ----------------------------------------DGL----------------- ------------------------------------------------------------ ----------------------------------------Q------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MQG-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------DTS-------------- ------------------------PGP--------------------------------- -------------------------------------MVKSPN--HGYCSSTKHTPDNLS D-------------------GLKINENIH-PE----------QEEEEEGLDNR------- ------------------------------------------------------------ ---------------------P-------------------------------------- -----------------------------------------------LSDS--------- ------------------------------------------------------------ ------------------------------------------------------------ -QRAITVDINDNNIDSGH-------SP--------------------------------L TQDTISC----------------------------------------------------- ---------SLTP-----------------------------------LSF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------S---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------P------------------------------------------SPV------ -------------------------------------------------------SSSP- ---------------------------LPCAGEPEP------------------DDDLST PVQESQ------------------------------------------------------ ------------------------------------------------------------ --PLFSSQQQSSLSMCHTTTTL-------------------------------------- ------------------------------------------------------------ -------CSTSPTT----------------QQAPDSQFV----P-----NNKLQEVTVVL STSTTSTT--------------SVS----------------SPSFTT----------AIP -LGLSQPMQES------------------------------------------------- ------------------------------------------------------------ ----------------------TSPESGTLDSACVPGTISHSQSQSCSQSKANLNNQPHK QIKQGHIW---------------------------------------------------- -------------------------------------NTQSRDP---SAAEEETDSEDDG G---LPSRGCRSQPRGVSGNRN----------------GSMQKESGPSSQREIHIFSAHQ ATERQSSRSINHSHKISEEIDLS--------LK--------------------------- NNCSIIASCNESES-EG-SVPELEETEPLRPSE--PQSL---------SSA-----DEGL SRPKQSRSEKKARKA--------------------MSKLGLKPVHGVTRITIRKSKSILF VISRPDVFKSPASDIYIVFGEAKIEDLSQQAHKAAAEKFKVP----------VTSSPLAP PVPPSLTIKEESEEEEEEVDEGGLEQRDIELVMAQANVSRAKAVRSLKHNKNDIVNAIME LTM---------------------------------------------