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---------SP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LKAVFD--------------------------ALDQDGDGFVRIEEFMEFA------TAY GAD--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTKF LDPSGLGVISFEDFHRGISAISNG--------------------GPE------------- -------------------P--Q--LY-SVNYSPGDGAVGCQEEYD-------------- -------------------E---------------------------------------- --------------------------------------------QNEVTDSAYLGSESTY SECETFTDEDT------------GALVPPEMHEDVETDSGIEATLH-------------- --------------------DPEDGS----------------------------N----- ---------------------------RFSLNSEL------------------------- --------HN-------------------------H--SLVTVIGGEEEHFEDFGESNT- -----------------SELLLES-------TTEG---PEGEGDSH-------------- 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------------------------------------LMEAIHKQEEINYRLQDYIDKIIV A----IMESNPSILE--------------------VK--- >ENSACLP00000016817 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M----E----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ----------------------------------------------NVSNLSFGDLQFEG DHTTISQTF--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------LHST----------------- ------------------------HIKDLSCTEKTEGLDEISDCTLSWLFSPNFADVIGK N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------SAQKELTLKRDSPLEDLEVLSSRVALITLSVPSSPVK-------TDT------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PFLLVD-LSNEHPAPNSESSGELNPQGVSEEL 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N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PFLLVD-LSNEHPAPNSESSGELNPQGVSEEL VKV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------PCKEQVDL--------P---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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-----------------------------------------HNTH-STPLECFEGSVP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LLDLDVPDFDSSLSLWPAS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------TASVIYTGT--------- ------------------------------------------------------------ -PLDVSSEESEVVHE--------------------------------------------- ------------------------------------------------------------ -------------------EAAVIRNLTLEQQGENDLLALG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LLNEPSSL TLPLVEDALIQGDLSSQSSSVENTPKDLMEDNICSEVKNQGNEAMALDPCLTVEEV---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------HDDESWDLKP----------------QEGVRNENS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PAAE--ERPADTTQLQGSGCEEVASFDFSVQDLN-TTSSEPEW----- ----TSEQAVETISLSNMVVDDSLPMVS-------------------------------- 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GAD--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTKF LDPSGLGVISFEDFHRGISAISNG--------------------GPE------------- -------------------P--Q--LY-SVNYSPGDGAVGCQEEYD-------------- -------------------E---------------------------------------- --------------------------------------------QNEVTDSAYLGSESTY SECETFTDEDT------------GALVPPEMHEDVETDSGIEATLH-------------- --------------------DPEDGS----------------------------N----- ---------------------------RFSLNSEL------------------------- --------HN-------------------------H--SLVTVIGGEEEHFEDFGESNT- -----------------SELLLES-------TTEG---PEGEGDSH-------------- ----------------------------------------------------LTQT---- --------PE----------------------------------QVNGSA-LRSP----- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ -M----E----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------LHST----------------- ------------------------HIKDLSCTEKTEGLDEISDCTLSWLFSPNFADVIGK N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ----------D------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PFLLVD-LSNEHPAPNSESSGELNPQGVSEEL VKV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------PCKEQVDL--------P---- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PAAE--ERPADTTQLQGSGCDEVASFDFSVQDLN-TTSSEPEW----- ----TSEQAVETVSLSNMVVDDSLPMVS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AV--SAGEEEV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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--------------------------------AV--SAGEEDV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LKAVFD--------------------------ALDQDGDGFVRIEEFMEFA------AAY GAD--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTKF LDPSGLGVISFEDFHRGISAISNG--------------------GPE------------- 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------------------------------------------------------------ ------------------------PMVS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SV--SAGEEDV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LKAVFD--------------------------ALDQDGDGFVRIEEFMEFA------AAY GAD--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTKF LDPSGLGVISFEDFHRGISAISNG--------------------GPE------------- -------------------P--Q--LY-SVNYSPGDGAVGCQEEYDE------------- ---------------YVCLE---------------------------------------- --------------------------------------------QNEVTDSAYLGSESTY SECETFTDEDT------------GALVPPEMHEDVETDSGIEATLH-------------- --------------------DPEDGS----------------------------NR---- -----SVLAAMP-------LFPG---KRFSLNSEL------------------------- --------HN-------------------------H--SLVTVIGGEEEHFEDFGESNT- -----------------SELLLES-------TTEG---PEGEGDSH-------------- ----------------------------------------------------ITQT---- --------PD-------------------------------------------------- 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-------VFQDKPVELDNLINISDFSCGDVQFE--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------ANQSINCKTSLHRT----------------- ------------------------HLEELSYTEKTEGPDEISDCTLSWLFPPNLTDVVGK NFA------------------CEELNVTQEAL---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------LE GSNGLSS---------------------QAELISLSVPVSPSKISTRNSEANI------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PFMLVD-LSNDTPCLPPESSGEFNPQGVSEEL V----------------------------------------------------------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------DQT SSQSEGG----------------------------------------------------- -------KP--------------------P------------------------------ ------------------------------------------------------------ --------------ELDELINISDFSCGNFHFEGHKSTVS---------------QASFL STQLDGFSFTDK----------------------------TDG----------------- ------------------------------------------------------------ -----------------------PSE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------TLKWLFSP-------- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ --------QLTDMVRDNSVSEE-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------LGLT QEDPVIPSKTSDTNPVD------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------TFLLVDLLSNELSYLPPESSGESNPQVVSEEL V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------HLSPEEQACPP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SQSRETLSPET GDKGLCP----------------------------------------------------- ------------------------------------------------------------ -----------------------D------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------QV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TDLPITCSTTLQGFPESCLP-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------HNNI-STPLESLQGSVP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LLDLEVPECEGNVSLCPVG----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------PPSVICTGE--------- ------------------------------------------------------------ -PLHLSPEDSQVEHEGTAKIIDLTSQQQRENDS--------------------------- ------------------------------------------------------------ ----------------CALG---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SSL TLPQAEDAFTQGDFTSESFSVESESKDLMEEKVCA----QGNETMALDPCLTVDEV---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------HNEDTWDLNPLDGLQGGSDPDPTPEQRE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------E--ERLTDTNQLEGPDCHDVASFGFSVQDLH-SSSREGGW----- ----TSEQTVETISLSKMVGDDSLPMVS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AV--NSREEQV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LKAVFD--------------------------ALDQDGDGFVRIEEFMEFA------AAY GAD--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTKF LDPSGLGVISFEDFHRGISAISNG--------------------GPE------------- -------------------P--Q--LY-NVNYSPGDGAVGCPEEYD-------------- -------------------E---------------------------------------- --------------------------------------------QNEVTDSAYLGSESTY SECETFTDEDT------------GALVPPEMHEDVETDSGIEATLH-------------- --------------------DPEDGG----------------------------N----- ---------------------------RFSLNSEL------------------------- --------HN-------------------------H--SLVTVIGGEEEHFEDFGESST- -----------------SELLLES-------SVEG---TEGEADSP-------------- ----------------------------------------------------LDQP---- --------AE----------------------------------HVNGSS-LLSP----- ------------------------------------------------------------ ------------------------------------------------------------ ----SAPAPLPDCFQSFLREEALDFFCSQCHKQISRLEDLSTRLNFLEM--TSSGKRLSS KKV--------ARHL--------LQ-----------------N-SSMTLDTMSDLTRDIL ELADNDITD--------------------------------------------------- ---------------KVLLLERRVAELEKESEASGEQHARLRQENLQLVH---------- -------------------------------------------RANALEEQLKEQELYAD EQLQQETRRHKEALVKLERERGLELENL----------------------QARVQQLDEE NSELRSCVPCLRANIERLEE-------EKQKLQDETEAMSDRLQEETESRRKMADKLSHE RHQSQKEKESTQELIEDLRKQLEHLQLYKLEAEAKKGR-TPGAGLQEYQTRTREAELEQE IKRLK------------------------------------------------------- -----------------------------------------------------QDNRSLK EQNDELNGQIINLSIQGAKNLMSAPFSDSLAAEINSVSRVE------------------- ------------------------------------------------------------ ------------------------------------LMETVHKQEEINYRLQDYIDKIIV A----IMECNPSILE--------------------VK--- >ENSMALP00000001837 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M----E----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------S------------------------- -----TILSG-------------------------------------------------- ---------------------------P-------------------------------- LGHKQWETEQP-FPFGFHTL-AS--------------------------------DS--- --G--------------------------------------------------------- DVLCHN------KSGQTGL-DCRTGDQ--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------QCEEEN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------VFQDKSIELDNLVNISDFSCGDLKFDR-------------------------- -----------------------------------------D------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------QSH---TSLHSARRD-------------- ---------------------------ELSYTENTEGPEEVTDCTLSWLVSPNLTDVVGK N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------SACEDLSLTQEAPFEPKNAFTTEADLISLSGPVSPLNIFERNSETST------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------G--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------D------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PFLMVDFLSNEPCCLHPDSSGELSPQGVSEEL V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------DLSQEEQAGLP---- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SQGSDTLSPET RGKGLFS----------------------------------------------------- ------------------------------------------------------------ -----------------------D------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------QV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TDLTVNCSAVLQGLPEKCLS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ENHV-SRPLERFEGSVP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LLDLEVPDCDSSLSLFPAN----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SSSVFCRGA--------- ------------------------------------------------------------ -PLDQSTEESVVEHR--------------------------------------------- ------------------------------------------------------------ -------------------EANVIRNLASEQQGESNSFTLGLS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------AELLS----------- -------------------------------------------------RTVL------- ---LAEDAFIQRDFTSESGSEEKVSKDLMEDKI-SEARNQGNESMALDLCLTGNEV---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------HDEETW----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------VSKQ------------------------GDV-------------------- ----------QNRSI-PNPMTEQRE----------------------------------- --------------EE--ERLTETNQLKGSDHHREDSFGFALQDLN--TSHDAVW----- ----TSEQTVETISLSKMVVDDSLPMVS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AV--KTREEDV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LKAVFD--------------------------ALDQDGDGFVRIEEFMEFA------AAY GAD--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTKF LDPSGLGVISFEDFHCGISAISSG--------------------GPE------------- -------------------P--Q--LY-NVNYSPGDGAVGCPEEYD-------------- -------------------E---------------------------------------- --------------------------------------------QNEVTDSAYLGSESTY SECETFTDEDT------------GALVPPEMHEDVETDSGIEATLH-------------- --------------------DPEDGG----------------------------N----- ---------------------------RFSLNSEL------------------------- --------HT-------------------------H--SLVTVICGEEEHFEDFGESNT- -----------------SELLLES-------TVDG---TGGEGDSP-------------- ----------------------------------------------------LVQP---- --------SE----------------------------------QLNGSS-LLSP----- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------SAGKRLSS KKV--------ARHL--------LQ-----------------N-SSMTLDTMSDLTRDIL ELADNDITD--------------------------------------------------- ---------------KVLLLERRVAELEKESEASGEQHARLRQENLQLVH---------- -------------------------------------------RANALEEQLKDQELHDD EQLQQEIRRHKEALSKLERERGLELENL----------------------QARLQQLDDE NSELRSCVPCLRANIERLEE-------EKRKLQDDTEAMSDRLKEETESRRKMADKLSHE RHQNQKEKECTQELIEDLRKQLEHLQLYKLEAEAKRGR-SSSAGLQEYQTRTREAELEQE IKRLK------------------------------------------------------- -----------------------------------------------------QDNRSLK EQNDELNGQIINLSIQGAKNLMSASFSDSLAAEINSVSRAE------------------- ------------------------------------------------------------ ------------------------------------LMEALHKQEEINYRLQDYIDKIIV A----IMESNPSILE--------------------VK--- >ENSBSLP00000042739 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M----E----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------A------------------------- -----TVLSG-------------------------------------------------- ---------------------------P-------------------------------- LGHIQWESDQP-FPVGFHTL-DS--------------------------------DN--- --G--------------------------------------------------------- GVLCQN------KGDQTGL-DFRHQSQ--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------LNEDGN---------------- -------VFQDKLVELDNLINMSDLTRGDLRF---------------------------- -----------K----------------------------EDSRASRRSVHIEGTG---- --------------------ENV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------DSTLAWLFS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------SSVTDDSSHEEPSPAQEASLETGNAHSAEAELIGLSEPVSTSNLSEGNSKINT ED---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PLLLVDLFSSKPLCLPLESAGELNSPGISEEL V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------DLSQDKQADLP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------PQDGQTLSPES GDNGLFP----------------------------------------------------- ------------------------------------------------------------ -----------------------D------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------QV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TDLLVTCSTTLPGSPESRLP-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------HNHV-STPLERSEGSVP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LLDLEIPDYDSSLSLCPAS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------AASVFSTGA--------- ------------------------------------------------------------ -PSHSSTEQSDVDHV--------------------------------------------- ------------------------------------------------------------ -------------------GAAVTTNLTLEQQGEND------SVVLALPSESC------- ------------------------------SSRTV------------------------- --------PEVRDAIIQG------------------------------------------ ------------------------------------------------------------ -------------------------------EFISDGCSVEQVPV--------------- ------------------------------------------------------------ --------------------------DLIKDELCSEVKNHRNEAMALDLC---------- ---------PTAEACG-------------------------------------------- ------------------------------------------------------------ ---------------------EDTWDLKPREDVQNESVPD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------QTIK---------------------------------- ------------------------------------------------------------ -----------------------RE----------------------------------- ---------------E--DRLTDTHQVKESDCHEVASFEFSLQELS-TS--EAVW----- ----TSEQT-ETLSCSKMVVDDSLPLVS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TV--NRREEDV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LKAVFD--------------------------ALDQDGDGFVRIEEFMEFA------AAY GAD--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTKF LDPSGLGVISFEDFHRGISAISNG--------------------GPE------------- -------------------P--Q--LY-SVNYSPGDGAVGCPEEYD-------------- -------------------E---------------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------P------------------------- -----TVVSG-------------------------------------------------- ---------------------------P-------------------------------- LGHTQWDPEQP-FPLGFQ------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------PSNSGGVLCPKSGQAGLDDKHDTFPKGEEEN LFVDKPFE----------------LDSFIKISSDFYK----------------------- ---------------------------GDLHFEG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GQPMVSQAS------- ------------------------------------------------------------ ------------------------HLQELSCADKTEGLDGINDCTLSWLFSSNFPDV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----SEKT--------------------------------------------------- ------TASEELTFT----------QNNSLEGS--------------------------- NVLGG------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------QADLINLSVPSSP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------ASRRNPETNAAD ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PFLLVD-------------------------- --------------------------LSDEL------------SCFAQESTSE------- ------------------------------------------------------------ ------------------------------------------------------------ ---PDLHG---------------------------VTV------------EQAGLP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ -------------------------------------------------LQ---TLSPET GDKGLFP----------------------------------------------------- ------------------------------------------------------------ -----------------------D------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------QV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TDLPITCSATVQGLLESCQP-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------RSHV-GKPQEHFEGSVP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LLDLDVPDFDS--SLCPAS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------PASDVCSGT--------- ------------------------------------------------------------ -PLEVSTDES-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------GVANADGALIRNFPPEEISEND--------------------- -----------------------------------SHSQSLPDKPSLLTLALTQDACCHD 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AV--TPREEDV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LKAVFD--------------------------ALDQDGDGFVRIEEFMEFA------AAY 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------STISKGSLHLDELSYSENNERADEISDLTLSWLFTPKPTDVVGQ N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------SACEELDLTQEAP----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EGSNIPSSQAYSPSDISKRNTETDTVD PFLLVD------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------VIANVPTCPPAESNP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------GEFNPLGVNEEL V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------DLSQGDQAGLP---- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------PDSVICTGS--------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ESVVDGHQLGGSDCHEVASFDFSVQDLN-SSSPVAGW----- ----TSEQNVETIPLSKMVADDSLPMVS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AV--DTREQDV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LKAVFD--------------------------ALDQDGDGFVRIEEFMEFA------AAY GAD--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTKF LDPSGLGVISFEDFHRGISAISNG--------------------GPE------------- -------------------P--P--LY-NVNYSPGDGAVGCPEEYD-------------- -------------------E---------------------------------------- --------------------------------------------QNEVTDSAYLGSESTY SECETFTDEDT------------GALVPPEMHEDVETDSGIEATLH-------------- --------------------DSEDGR----------------------------N----- ---------------------------RFSLNSEL------------------------- 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EQNDELNGQIINLSIQGAKNLMSASFSDSLAAEINSVSRSE------------------- ------------------------------------------------------------ ------------------------------------LMEAIHKQEEINYRLQDYIDKIIV A----IMESNPCILE--------------------VK--- >ENSCSEP00000018273 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M----E----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------P------------------------- -----TVLSA-------------------------------------------------- ---------------------------P-------------------------------- LGHKQWESEQT-FPHGFHTL-DS--------------------------------DN--- --R--------------------------------------------------------- GVLCQN------TGDRTGL-DFRDTDH--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------EQKNYQREEVND----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------FQAKPVELGSFMNISNFSLGDLQFE--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PNKSTLISASDHSPSLEELSYIEKTDRTGDNIDAD----- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------LSWLFPSNLTDVVGK HSASTHLDLTCEKYQEDLEAPC-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----G------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------QDELITLSVPVSPSKVSVGTPETNV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------G--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------D------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ----------------------------PFLLVDLLSDEPVCLP---TGEFNPLGVSEEL I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------DLSQEDQACLP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SQSSDTWSPET RDKGLFP----------------------------------------------------- ------------------------------------------------------------ -----------------------D------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------QV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TDLPV----------------GGRT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------IAQDLREGCFSENHM-STSAEFFEGSLP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LLDSVVPDYDNSLNLFPDSPVSV------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------TP--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TTVLPHLLTQESGVQQGEAGVISKLAS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EQQGENESCAVG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LSDEPSSQ AVTLAEDALIQGDITTECYSLKDEFKDVMEDKICSEAKTQENETMALDLCFTADEV---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------PDHETWDLK-------------------------------- ----------------AL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ED--------LQSRSLPESTAEQTDEYGVTASN MLK--------------------------------------------------------- ------------------------------------------------------------ ---------------E-------------SDFHEVTSLEFSVHDLT-TSSPEAGW----- ----TSEQDVETLSLSKMVVDDSLPMVS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AD--NTREEDV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LKAVFD--------------------------ALDQDGDGFVRIEEFMEFA------AAY GAD--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTKF LDPSGLGVISFEDFHRGISAISNG--------------------GPE------------- 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-------------------------------------------RANALEEQLKEQELHAD ETLQQEARRNKEAMSKLERERGLELENL----------------------QGRLQQLDEE NSELRSCVPCLRANIERLEE-------EKRKVQDEFEVVSDRLNDETEMRRKMGDKLSHE RHQNQKEKECTQELIEDLRKQLEHLQLYKLEAESKKGR-SPGAGLQEYQTRTREAELEQE IKRLK------------------------------------------------------- -----------------------------------------------------QDNRSLK EQNDELNGQIINLSIQGAKNLMSASFSDSLAAEINSVSRSE------------------- ------------------------------------------------------------ ------------------------------------LMEAIHKQEEINYRLQDYIDKIIV A----IMESNPSILE--------------------VK--- >ENSORLP00020010655 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M----E----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------P------------------------- -----TVLSG-------------------------------------------------- ---------------------------P-------------------------------- LGHTQWESEQP-FPLGFPIL-DS--------------------------------DN--- --G--------------------------------------------------------- AVLCQN------KSDQTGL-DFRKSDQN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ET-------------------VLLNGEEKR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------FADKPVELGNLIN--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GAT FSSEDLKFDGGHLTYSESSHRSARFNELSCRETAEGFGE--------------------- ------------------------------------------------------------ ----------------------------------------IADYTLSWFLSPDFADVIGK T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------SACQE------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------STFTQDPTVECSDGEP---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AELANLSAPFSPFEVSDCNRE-------------------------- ---------------------------------------------------------INT TD---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PFLIVDLLSDENPCLTQKLSHELIPQGFGEKL I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------DLSFEEQEDLP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SLTGEMVSPDT SHKGLFP----------------------------------------------------- ------------------------------------------------------------ -----------------------D------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------QV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TDLPISSS----------------SPAAQGLLESNQLLNNISQSQEG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------FEGSVP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LLDLKVPHFESDVSLCPPA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------VACTGALETPTKESEVAQTIA VKILP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EQQGEND------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ILNLDLSDSSSFLTRPPAEDASTHGNLTSERNFVENLPKAVM -------------------EVKEEHAGEETTELYLSWTVEEA------------------ -------------------HKDDSWDLEPQD----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------IVHNRATISPKTEQNEDETLI DNNQLEDAHSHN------------------------------------------------ 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------------------------------------------------------------ LKDVFD--------------------------ALDQDGDGFVRIEEFMEFA------AAY GAD--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTKF LDPSGLGVISFEDFHRGISAIS-G--------------------SPE------------- -------------------T--Q--LY-SVNYSAGDGAVGCQEEYD-------------- -------------------E---------------------------------------- --------------------------------------------QNEVTDSAYLGSESTY SECETFTDEDT------------GALVPPEMHEDVETDSGIEATLH-------------- --------------------DPEDGG----------------------------N----- ---------------------------GFSMNSDL------------------------- --------HN-------------------------T--SLVTVIGGEEEHFEDFGESNN- -----------------SELL-ES-------NEED---SVVHLDSP-------------- ----------------------------------------------------LSEP---- --------PV----------------------------------QVDGSS-VLSP----- ------------------------------------------------------------ ------------------------------------------------------------ ----SAPASLPDCFQSFLREEALDFFCSQCHKQISRLEDLSTRLNFLEM--TSSGKRLSS KKV--------ARHL--------LQ-----------------N-SSMTLDTMSDLTRDIL ELADNDITD--------------------------------------------------- ---------------KVLLLERRVAELEKESDASGEQHTRLRQENLQLVH---------- -------------------------------------------RANALEEQLKEQEVYAE EQLQQENRRHKEAISKLEREKGLELENL----------------------QARLQQLDEE NSELRSCVPCLRANIERLEE-------EKRKLHDEAEVMSQRLEEETEARRKMADKLSHE RHQNQKEKESTQELIEDLRKQLEHLQLYKLEAEAKRGR-TPAAGLQEYQTRTREAELEQE IKRLK------------------------------------------------------- -----------------------------------------------------QDNRTLK EQNDELNGQIINLSIQGAKTLMSASFSDSLAAEINSVSRVE------------------- ------------------------------------------------------------ ------------------------------------LMETVHKQEEINYRLQDYIDKIIV A----IMECNPSILE--------------------VK--- >ENSORLP00000032913 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------A------------------------- -----TVLSG-------------------------------------------------- ---------------------------P-------------------------------- LGHTQWESEQP-FPLGFPIL-DS--------------------------------DN--- --G--------------------------------------------------------- AVLCQN------KSDQTGL-DFRKSDQN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ET-------------------VLLNGEEKR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------FVDKPVELGNLIN--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GAT FSSEDLKFDGGHLTYSDSSHRSARFNELSCREAGEGFGE--------------------- ------------------------------------------------------------ ----------------------------------------IADYTLSWFLSPDFADVIGK T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------SACQE------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------STFTQDPTVEGSDGEP---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AELASLSAPFSPFEASNCDRE-------------------------- ---------------------------------------------------------INT TD---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PFLIVDLLSDENPCLTQKLSHELIPQGFGEKL I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------DLSFEEQEDLP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SLTGEMVSPDT RHKGLFP----------------------------------------------------- ------------------------------------------------------------ -----------------------D------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------QV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TDLPISSS----------------SPAAQGLLESNQLLNNISQSQEG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------FEGSVP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LLDLKVPHFESDVSLCPPA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------VACTGALETPTKESEVAQTIA VKILP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EQQGEND------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ILNLDLSDSSSFLTRPPAEDASTHGNLTSERIFVENLPKAVM -------------------EVKEEHAGEDTTELYLSWTVEEA------------------ -------------------HKDDSWDLEPQD----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------IVHNRASISPKTEQNEDETLK DNNQLENAHSHN------------------------------------------------ ---------------EV-------------------SLDFLAQNTK-ISSSEAEW----- ----TSGPPVVTVSLSKMVEDDSLPMVS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SV--NKREEDA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LKDVFD--------------------------ALDQDGDGFVRIEEFMEFA------AAY GAD--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTKF LDPSGLGVISFEDFHRGISAIS-G--------------------SPE------------- -------------------T--Q--LY-SVNYSPGDGAVGCQEEYD-------------- -------------------E---------------------------------------- --------------------------------------------QNEVTDSAYLGSESTY SECETFTDEDT------------GALVPPEMHEDVETDSGIEATLH-------------- --------------------DPEDGG----------------------------N----- ---------------------------GFSMNSDL------------------------- --------HN-------------------------T--SLVTVIGGEEEHFEDFGESNN- -----------------SELP-ES-------NEED---SVVHLDSP-------------- ----------------------------------------------------LSEP---- --------PV----------------------------------QVDGSS-VLSP----- ------------------------------------------------------------ ------------------------------------------------------------ ----SAPASLPDCFQSFLREEALDFFCSQCHKQISRLEDLSTRLNFLEM--TSSGKRLSS KKV--------ARHL--------LQ-----------------N-SSMTLDTMSDLTRDIL ELADNDITD--------------------------------------------------- ---------------KVLLLERRVAELEKESDASGEQHTRLRQENLQLVH---------- -------------------------------------------RANALEEQLKEQEVYAE EQLQQENRRHKEAISKLEREKGLELENL----------------------QARLQQLDEE NSELRSCVPCLRANIERLEE-------EKRKLHDEAEVMSQRLEEETEARRKMADKLSHE RHQNQKEKESTQELIEDLRKQLEHLQLYKLEAEAKRGR-TPGAGLQEYQTRTREAELEQE IKRLK------------------------------------------------------- -----------------------------------------------------QDNRTLK EQNDELNGQIINLSIQGAKNLMSASFSDSLAAEINSVSRVE------------------- ------------------------------------------------------------ ------------------------------------LMETVHKQEEINYRLQDYIDKIIV A----IMECNPSILE--------------------VK--- >ENSORLP00015009138 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M----E----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------P------------------------- -----TVLSG-------------------------------------------------- ---------------------------P-------------------------------- LGHTQWESEQP-FPLGFPIL-DS--------------------------------DN--- --G--------------------------------------------------------- AVLCQN------KSDQTGL-DFRKSDQN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ET-------------------VLLNGEEKR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------FVDKPVELGNLIN--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GAT FSSEDLKFDGGHLTYSDSSHRSARFNELSCRETTEGFGE--------------------- ------------------------------------------------------------ ----------------------------------------IADYTLSWFLSPDFADVIGK T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------SACQE------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------STFTQDPTVEGSDGEP---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AELASLSAPFSPFEVSNCDRE-------------------------- ---------------------------------------------------------IST TD---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PFLIVDLLSDENPCLTQKLSHELIPQGFGEKL I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------DLSFEEQEDLP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SLTGEMVSPDT 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LLDLKVPHFESDVSLCPPA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------VACTVALETATKESEVAQTIA VKILA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EQQGEND------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ILNLDLSDSSSLLTRPPAEDASTHGNLTSERIFVENLPTAMM -------------------EIKEEHPGEETTELYLSWTVEEA------------------ -------------------HKDDSWDLEPQE----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------IVHNRAAISPKTEQNEDETLK DNNQLEDAHSHN------------------------------------------------ ---------------EV-------------------SLDFLAQNTN-ISSSEAEW----- ----TSGQPVGTVSLSKMVEDDSLPMVS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SV--NKREEDA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LKDVFD--------------------------ALDQDGDGFVRIEEFMEFA------AAY GAD--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTKF LDPSGLGVISFEDFHRGISAIS-G--------------------SPE------------- -------------------T--Q--LY-SVNYSPGDGAVGCQEEYD-------------- -------------------E---------------------------------------- --------------------------------------------QNEVTDSAYLGSESTY SECETFTDEDT------------GALVPPEMHEDVETDSGIEATLH-------------- --------------------DPEDGG----------------------------N----- ---------------------------GFSMNSDL------------------------- --------HN-------------------------T--SLVTVIGGEEEHFEDFGESNN- -----------------SELL-ES-------NEED---SMVHLDSP-------------- ----------------------------------------------------LSEP---- --------PV----------------------------------RVDGSS-VLSP----- ------------------------------------------------------------ ------------------------------------------------------------ ----SAPASLPDCFQSFLREEALDFFCSQCHKQISRLEDLSTRLNFLEM--TSSGKRLSS KKV--------ARHL--------LQ-----------------N-SSMTLDTMSDLTRDIL ELADNDITD--------------------------------------------------- ---------------KVLLLERRVAELEKESDASGEQHTRLRQENLQLVH---------- -------------------------------------------RANALEEQLKEQEVYAE EQQQQVNRRHKEAISKLEREKGLELENL----------------------QARLQQLDEE NSELRSCVPCLRANIERLEE-------EKRKLYDEAEVMSQRLEEETEARRKMAAKLSHE RHQNQKEKESTQELIEDLRKQLEHLQLYKLEAEAKRGR-TPGAGLQEYQTRTREAELEQE IKRLK------------------------------------------------------- -----------------------------------------------------QDNRTLK EQNDELNGQIINLSIQGAKNLMSASFSDSLAAEINSVSRVE------------------- ------------------------------------------------------------ ------------------------------------LMETVHKQEEINYRLQDYIDKIIV A----IMECNPSILE--------------------VK--- >ENSOMEP00000015019 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M----E----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------P------------------------- -----TVLSG-------------------------------------------------- ---------------------------P-------------------------------- LGHTQWESEQP-FPLGFPIL-DS--------------------------------DN--- --G--------------------------------------------------------- AVLCQN------KSDQTGL-DFRKSDQN-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------ET-------------------VLLNGEEKR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------FVDKPVELENLIN--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GAA FSSEDLKFDGGHLTYSDSSR-----------------GETA------------------- ------------------------------------------------------------ -----------------------------------EGFDGIADYTLSWFLSPDFADVIGK T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------SACQE------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PGFTQDPTVEDSDGAPSS-------------- ------------------------------------------------------------ -----------------------------------------------------------P FKVSESEINTTDPFLID------------------------------------------- --DSPSLTQKPLN----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------PQSFGEKL I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------DLSFEEQEDLP---- ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SQMGETASPDT SLKGLFP----------------------------------------------------- ------------------------------------------------------------ -----------------------D------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------QV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ADLPTSSS----------------SPA------------------QGLL--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------ESNIS------------------ESFEGSVP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LLDLKVPHFESDVSLCPPA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------FASVASAGVLDTPTKDSEVAQTTA AQNLP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EQQGEND------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ILHVDLSNGSSFLTLAPAEDACTQGNLTS-----ENLPKAVM EAEEKHQGKHKSSTVEEVCE---------------------------------------- ---------------------DDPWDLEPQE----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------TVHNRAAVSTKTQENEDDKPT GNNQLEDAHSHE------------------------------------------------ ---------------EV-------------------PFDFSAQNTS-LSSPEAEW----- ----TSEQPVVTVSLSKMVEDDSLPMVS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AG--NKREEDV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LKDVFD--------------------------ALDQDGDGFVRIEEFMEFA------AAY GAD--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTKF LDPSGLGVISFEDFHRGISAIS-G--------------------SPE------------- -------------------P--Q--LY-SVNYSPGDGAVGCQEEYD-------------- -------------------E---------------------------------------- --------------------------------------------QNEVTDSAYLGSESTY SECETFTDEDT------------GALVPPEMHEDVETDSGIEATLH-------------- --------------------DPEDGG----------------------------N----- ---------------------------GFSLNSDL------------------------- --------HN-------------------------N--SLVTVIGGEEEHFEDFGESNN- -----------------SELL-ES-------NVEE---SEVHLDSP-------------- ----------------------------------------------------LSQP---- --------PV----------------------------------QVNGSS-VLSP----- ------------------------------------------------------------ ------------------------------------------------------------ ----SAPASLPDCFQSFLREEALDFFCSQCHKQISRLEDLSTRLNFLEM--TSSGKRLSS KKV--------ARHL--------LQ-----------------N-SSMTLDTMSDLTRDIL ELADNDITD--------------------------------------------------- ---------------KVLLLERRVAELEKESDASGEQHARLRQENLQLVH---------- -------------------------------------------RANALEEQLKEQEVYAE EQLQQENRRHKEAISKLEREKGLELENL----------------------QARLQQLDEE NSELRSCVPCLRANIERLEE-------EKRKLHDEAEVMSQRLEEETEARRKMADKLSHE RHQNQKEKESTQELIEDLRKQLEHLQLYKLEAEAKRGR-TPGAGLQEYQTRTREAELEQE IKRLK------------------------------------------------------- -----------------------------------------------------QDNRTLK EQNDELNGQIINLSIQGAKNLMSASFSDSLAAEINSVSRAE------------------- ------------------------------------------------------------ ------------------------------------LMETVHKQEEINYRLQDYIDKIIV A----IMECNPSILE--------------------VK--- >ENSTNIP00000015789 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LKAVFD--------------------------ALDQDGDGFVRIEEFLEFA------AAY GAD--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTKF LDPSGLGVISFEDFHRGISAVT-------------------------------------- ---------------------------------------------DGEFTLESAGAPGES TTHASASIRYLYAYHH---E---------------------------------------- --------------------------------------------QNEVTDSAYLGSESTY SECETFTDEDT------------GALVPPEMHEDVETDSGIEATLH-------------- --------------------DPEDTGTRSLTLNG--------------------NSCGGW QSCYQH------------------------------------------------------ ------------------------------------------IIGGEEEHFEDFGESNT- -----------------SELLLES-------AVDG---TEQPGDSQ-------------- ----------------------------------------------------LLEP---- --------PA----------------------------------QVNGSS-PLSP----- ------------------------------------------------------------ ------------------------------------------------------------ ----S--------FQSFLREEALDFFCSQCHKQISRLEDLSTRLNFLEM--TS------- -----------------------LEIRAALCWLISRVLFHTKN-SSMTLDTMSDLTRDIM ELADNDITD--------------------------------------------------- ---------------KVLLLERRVAELEKESEASVEQHARLRQENLHLVH---------- -------------------------------------------RANALEEQLKEQELQAH EQLQQESRRQKEATVKLEREREMELENL----------------------NTRLQQLDEE NSELRSCVPCLRANIGRLEE-------EKMKLQDERDTMSDRLQEETEFRKKMADKLSHE RHQSQKEKEGTQELIEDLRKQLEHLQLYKLEAEAKRGR-TPGAGLQEYQTRTREAELEQE IRRLK------------------------------------------------------- -----------------------------------------------------QDNRSLK EQNDELNGQIINLSIQGAKNLMSASFSDSLAAEINSVSRSE------------------- ------------------------------------------------------------ ------------------------------------LMEAVHKQEEINYRLQDYIDKIIV A----IMESNPSILE--------------------VK--- >ENSGWIP00000021169 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M----E----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------P------------------------- -----TVVSG-------------------------------------------------- ---------------------------P-------------------------------- LGHSQWESEKT-FPLGFQTL-ET--------------------------------DN--- --G--------------------------------------------------------- ------SDPHSSKTGQTG---FRNGDH--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------QDQM SQQNE------------------------------------------------------- ----------------------------------------------EDR----------- ------------------------------------------------------------ -------IFTNKSVVLESLLDVSNFSCGDLQFKG-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DCTVSLCSTERA------------------------------------ ---------------------------DLSCTEKREGLDENTESTLSWLFSPNFSYVIGE T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ---------------IDCKELSSIKDSSPETSVVLNDQTEPTSLSVQSHSGKFSERTAET IVD--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------SFLLVD-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------HPPITPESLGESKSPGVSEESREEQVAPLV------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------TVSPET RDKGPFP----------------------------------------------------- ------------------------------------------------------------ -----------------------A------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------QM------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TDL---------------------------------------------LCGSA----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LQCLPENCFQPNLI------------------STP-EGFEGSVP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LLDSEVPDSDSSQSLCPVS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------PASVICT----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------DELLKTSSEDIHLIHAANTSQQ CNDHDSPAPGFSEQPSSLTPLADDVLSRGDHLCERS------------------------ 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----SAPASLPDCFQSFLREEALDFFCSQCHKQISRLEDLSTRLNFLEM--TSAGKRLSS KKV--------ARHL--------LQ-----------------N-SSMTLDTMSDLTRDIL ELADNDITD--------------------------------------------------- ---------------KMLLLERRVAELEKESEASVEQHARLRQDNLHLVH---------- -------------------------------------------RANALEEQLKEQEVLAD EQQQQETRRHKEALNKMERERGLELENM----------------------QARLQQLDEE NSELRSCVPCLRANIERLEE-------EKTKLMDETEAMSDRLQDEIESRRKMADKLNHE RHQNQKEKESTQELIEDLRKQLEHLQLYKLEAEAKRGR-SPGAGLQEYQTRTREAELEQE IKRLK------------------------------------------------------- -----------------------------------------------------QDNRALK EQNDELNGQIINLSIQGAKNLMTASFSDSLAAEINSVSRTE------------------- ------------------------------------------------------------ ------------------------------------LMEAVHKQEEINYRLQDYIDKIIV A----IMECNPSILE--------------------VK--- >ENSSPAP00000002413 ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------P------------------------- -----TVLSG-------------------------------------------------- ---------------------------P-------------------------------- LGHTQWESEQP-FPLGFQTL-DT--------------------------------DN--- --G--------------------------------------------------------- GVPCQS------QSGQTGL-DFRHQDQ--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------TSHHSEEGNVDKPVDLDK LINHLSRGDLQFEGDLSPVSQASLHKEELSYTEKIEGLDEISDCTLSWLFSPNFPDVIGK N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ --TDLLVTSSPTLQGLPESCLP-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------HDHI-STPLECFEGSVP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LLDVEVPDIDSSLSLCPAS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------PASIICTDA--------- ------------------------------------------------------------ -PLDVSTEESEVVHA--------------------------------------------- ------------------------------------------------------------ -------------------EATVTENLASEQQGENDSLALH------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LSDETSSL TLPPAEDALIQGDFSSESVSVENVSKDLMEEEICSEATNQGNKEMALDLCLTVEEV---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------RDEESWDLKPPEDVQNGGVSDLTAEQRE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------E--ERTTDTNQLEVSDCNDV-----------------AGW----- ----TSEQAVETLSISKMVVDDSLPMVS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AV--STREEDV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------PLESSSALSSQEELISLSVPASPSKIS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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-----------------------G------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------QV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TDLLVTCS----------------PPT------------------QG----SAESGVS SDH--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------LSTSPLQA------------------------------------EGSVP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LLDLAVPDTDGSLSLSPTSP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GECWASSLHESEVKCTGEISNLTSEL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------GEND---------------SCAVDVPAE TSALTATPAEDAFVPGEFSENCFVKDCKDPT----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EDPVCSEAKPQGN------------------ ---------------G-------------------------------------------- ------------------------------------------------------------ --------AMASCLAAADVHNNETLDLVPQKGAQNGSDPD-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LVTEQQGEERLAGTDQSGGSSDFLVE DLLGSAPEEGR------------------------------------------------- ----TSEQPV-TISLSKM-VDDSLPMVS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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---------SPETVGRVSLPLDDIMPGSRSQEGSAQGTEDQDLPPSSPLEGEPCQSSGGT AAWADFEPTAQTTTCLSRRASPSSLERGASPDSACQPGTNADSPVAMEDLASERDVLDWL GDADRLDQRTLHATCAVGEEWALPPEESRLEAPRAAPVEALLGLPPAEDAEGAEVDEPSA LRAVFD--------------------------MLDQDKDGFVRTEEFVQFA------TVY GAE--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTRF LDPTGLGVISFEDFFRGIAAINSG--------------------GAD------------- -GQPFETRVYGGAVESASCP----------------------EEFED------------- ---------------FTALE---------------------------------------- --------------------------------------------QNEVTDSAYLGSESTY SECETFTDEDT------------GTLVHHELHEEVETDSAIDAALH-------------- --------------------YGDDSA----------------------------T----- ----------------------GSHCHRLSLDSEL------------------------- --------NS-------------------------H--SLVTIIGQEEEHFEDFGEGIE- -----------------SELQ--------------------------------------- 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-------------------------------------------RANAYEEQLKEQELLAD EQLQHEIRRHKEALSKLERERGLEMENL----------------------QSRLQQLDEE NSELRSCVPCLRANIERLEE-------EKLKLEDEVDVMTVKWQDEMETRQKMADKLSHE RHQNQKEKESTQELIEDLRKQLEHLQLYKLEAEAKRGR-SPSAGLQEYQTRTREAELEQE IKRLK------------------------------------------------------- -----------------------------------------------------QDNRSLK EQNDELNGQIINLSIQGAKSLMSASFSDSLAAEINSVSRSE------------------- ------------------------------------------------------------ ------------------------------------LMEAVHKQEEINYRLQDYIDKIIV A----IMESNPSILE--------------------VK--- >ENSMMOP00000002569 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M----E----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------P------------------------- -----TVLSG-------------------------------------------------- ---------------------------P-------------------------------- LGHTQWESEQP-FPLGFHTL-GS--------------------------------DN--- --G--------------------------------------------------------- GVRCTN------KTGQTGFQDFRNGDQ--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------TSHQNEDF----------------------------------- -------VFTDKPVRLDSLINISDFSCGDLKFEGDQSSISQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------VSLHST----------------- ------------------------HIGESTLTDKNEGPNEISDCTLSWSFSHELSDVFGK Y----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------SASEELSL---------------------------------------------- ------------------------------------------------------------ ---AEA------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------D------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------TKTSNALSSQAELISLGVL-----------------PS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------LSKI------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------P------------------------ ------------------------------------------------------------ ------------------------ETTTV------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EPSLLVDLLSNETPCLPSEPSGEMDPQGVSEEL V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------NLSQEEQAGLP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------TNNRETLSPET GDKGLFS----------------------------------------------------- ------------------------------------------------------------ -----------------------S------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------QV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TDLLVTGRTTLQGTPENSLS-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------QDQI-STSLEYVEGSVT-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LLDLEIPDCDSSPSLCPASPGA-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------PV---------- ------------------------------------------------ESSLQECNVKHI GTIVITN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -P---------------------TSEQD-------------------------------- ------------------------------------------------------------ ---------------------------------ENDSLTLDLSM---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------EE--------------------------------------------- ------------------------------------------------------------ ----AEDAFAPGDFTSESYSVENKYDDLSKKRISSEAKPQGDEAMALDLCLTPKEV---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------RGDKTWDLTPPEGVQNGCIPDLITEQRD------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ERLADTNQLEGSDSPEVASFDFSVQDLH-SSAPEAEW----- ----TSEQTV-TISLSKMVVDDSLPMIS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AV--STREEDV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LKAVFD--------------------------ALDQDGDGFVRIEEFMEFA------AAY GAD--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTKF LDPSGLGVISFEDFHRGITTISNG--------------------DPN------------- -------------------------LY-SVNYSQGVGAVCCPEEYD-------------- -------------------E---------------------------------------- --------------------------------------------QNEVTDSAYLGSESTY SECETFTDEDT------------GALVPPEMHEDVETDSGIEATLH-------------- --------------------DPEDSG----------------------------N----- ---------------------------R---------------------------SVSLS -----------------------------------------------EEHFEDFGESNT- -----------------SELLLES-------SVEG---TEGQGDSP-------------- ----------------------------------------------------LVKP---- --------SE----------------------------------QVNGSS-ILSPRYELV FSRQTDMLYKLNYNLKSLKI---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------VLLLERRVAELEKESETSVEQHARLRQENLQLVH---------- -------------------------------------------RANALEEQLKEQELHAD EQLQQETRRQKEALIKLERERGLELENL----------------------QGRLQQLDEE NSELRSCVPCLRANIERLEE-------EKVKLQDDNEAMSERLLDETESRKKMADKLSHE RHQSQKEKEATQELIEDLRKQLEHLQLYKLEAEAKRGR-TPGAGLQEYQTRTREAELEQE IKRLK------------------------------------------------------- -----------------------------------------------------QDNRSLK EQNDELNGQIINLSIQGAKNLMSASFSDSLAAEISSVSRTE------------------- ------------------------------------------------------------ ------------------------------------LMEAVHKQEEINYRLQDYIDKIIV A----IMESNPSILE--------------------VK--- >ENSIPUP00000000630 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M----E----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QVLSS-------------------------------------------------- ---------------------------P-------------------------------- RGHSDWESDQN--SLGFLLL-DN--------------------------------DDDVA ADG------------GHENPERRHRGEPGI------------------------------ -----------------------------VSLSFDEIFQDSSLNLDEFFRASRYSGLDQA CPWERGSDCVSPSWD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------IQPSLPQKPAREDCRE------AP------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------HGAG---------------T ADLISFNSN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APS P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------THTCTSMQA------------------------------------- ------------------------------VDISQPTGTVDTDCPLDGLIGQLP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LDPVM--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------D------------------------------------------------- ----QTLSQTLPAQRTSVTEETPDSHWTKDLTSSQTTPEDVTDILCANLLDLAAESSSRT ASYSFENSNEALITSPFIYDLSSSLQTLVSCSDALDEVSPMLFLES-------------- -------------------------------------------P---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------VQPCDG SLAIFQTVGTTVTGLSSEQEREVPAISNTIRGDASEVQSPAGPLASSKPFVQERTLAGSD SEAKPETPNESVATGGPPETSRLGLSDEDACEDEEIVEMEEVAERDIPPHDPLVQELQSD FTQAVLLFSPTF------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---VPEQTAPVQSTSTSPVSLC-------------------------------------- -------------------------------------------------------PQTDV SPEYSNDELRVNTQGAAFEKSPDLNENSNLSVISDSHFDDVHNAKLLASEKEIIIHTIPA LKKEPPPVSPLLRLTLEANAETDAISHDSESETHTSSEIESKRNPSESLKSPEGTGEEQT INMPNMDTSDTLAALDTHFHLHVQEVESVHTSVNGTTQHCQDPNGCTAEINQQPNTQDES ESFGFSAHNCTPEKFVTPKDIHATSDDLQDTHRLTESSDGSVNTHTPDFTPVSKENTFLC ALLPAQGSIKAEEGIDREPVD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------VTYTPESV--------------------------------------- ------------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GPLDSTLLSGAD---SPLS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------QVGVAIGQE RGAATSRLCQSADVKLDGE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --TDLP------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----EYLRQADLSQVAEPKLNS---LRDES----------------------------- ------------------------------------------------------------ ---------------------------------------------------------PS- ------------------------------------------------------------ ------------------------------------------------------GVC--- -----------------------------------------------------PLEETCP LLMEDSVVV--------------------------------------------------- ------------------------------------------------------------ ------------------PD---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ GP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------DNAE---------------------------- ------------------------------------------------------------ --------------------------------------------MALELCVSSDMIQD-- ---------------GC------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SGAGA------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------LP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AA--NPQDDEH----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LRAVFQ--------------------------ALDQDGDGFVRIEEFMEFA------TAY GVE--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTRF LDPSGLGVISFEDFHRGITAISNG--------------------GSD------------- -------------------P--D--LY-KLQLTTGD-ANGAGEEYD-------------- -------------------E---------------------------------------- --------------------------------------------QAEVSDSAYLGSESAY SECETFTDEDT------------GALVHPELHEDVETDSGIGNTLA-------------- --------------------ESEE--------------R---------------N----- ---------------------------RFSLGSDL------------------------- --------HG-------------------------H--ALVAVIGGEEEHFEDFGESNS- ----------------ASDLLLAN-------QEEGRAAPEGEGD---------------- ------------------------------------------------------------ --------PE------------PHPHAGSPAHRPPM---------------LLTP----- ------------------------------------------------------------ ------------------------------------------------------------ ----SS-EPFPSSFRNFLQSESLEFFCTHCHKQISRLEDLSTRLHLLEM--NSSSKRLSS KKA--------ARHL--------LQ-----------------S-SG--LDRMSDLSRDIL DLADSDIAD--------------------------------------------------- ---------------KVLLLERRVSELEKDSAASEEQHARLRQENLTLVH---------- -------------------------------------------RANALEEQLKEQEVRAD ESLNTLGRKHRDALSKLQRERELEIENL----------------------QARLHQLDEE NSELRSCVPCLRANIERLEE-------EKRKLQDEVDDMTDRLNEETESRRKTADKLSHE RHTSQKEKETTQELIEDLRKQLEMLQLFKLETEARRGR-SPAAGLQEYNTHMRENELEQE IRRLK------------------------------------------------------- -----------------------------------------------------QDNRSLK EQNDELNGQIINLSIQGAKSLFTESLSESLAAEINNVSRAE------------------- ------------------------------------------------------------ ------------------------------------LMEAIQKQEEINFRLQDYIDRIIV A----IMESNPSILE--------------------VK--- >ENSAMXP00005035692 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M----E----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QVLSS-------------------------------------------------- ---------------------------P-------------------------------- RGHSDWESDQN--SLGFLLL-DM--------------------------------DNEVV T-G------------SSEKAERHQRGESGI------------------------------ -----------------------------VSLSFDDIFQENAFNLDDLFRASRYSGLEQT YPWEQSSECVSPQWD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------RQP--------------------PC----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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----------------------------LEPLL--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------D------------------------------------------------- ----QTLC---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------PN--------------- ---------------------LSPQRTTELEQHFVSTSQIWEPNLDP------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------SQSIPEQVGNLMCVDSENVLDLAAVFAAE EGSGRTAVCEPELSPTPLTPLPFSCPFSSTPSCLD------------------------- ------------------------------------------PDPP----------GDP- ------------------------------------------------------------ --------------------------------------------TSLALCIESHVQPCDE S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------CAPHLVTDATIAGMSTLQDANT PSASNIESDSTLGVHSTQSPLDLSLDESAAQTVHEGTGLDPLALSGTPP----------- ------------------------------------------------------------ ----------------------------------------------------ESILPGPS TDISLSRSQLNLNAESPCEGDETLEMGGGEVDVLSHVVLKNSVEYDLESSVLSLEDILAL TENVPDQTTPVESTSASKVLLCCETELIIENSGDTDELCVKNTHTPETPSLGSIPSMSPP DDIP--------------------------------------------------KP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------EPLDSEREAPADSFDALKSQTDSDSTASSETKLDSVSPVIEAV LNISLEPTAET------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------TPETEMVTPD SESQSHNSHCCINDLPRETGN----------EQTINTCSEDILNDVSHTLTSVETLPHSP PLHFQEAPVWLCESDNTSVDYTTQQDGNELDEGTTKNQLPAFQMESENISNGDHNC---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EYAHTQDAAPDECATPSEPHETN GYAQNVTAEDHLISHDDDVVDDNQNTPHTLIDTAGENIMETNMVDLTTVPMDNSPSSTKE EREDIDNDQEDDHVTHSSQCV--------------------------------------- ------------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------EVC--- -----------------------------------------------------PPEEICT PLMEENIDV--------------------------------------------------- ------------------------------------------------------------ ---------------LDIPD---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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--------------------------------------------MALDLCLSSDAAQE-- ---------------GS------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VAAGAVPVA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TVP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AA--STRDEER----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LQAVFQ--------------------------ALDQDGDGFVRIEEFMEFA------TAY GAE--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTHF LDPSGLGVISFEDFHRGITAISNG--------------------GSD------------- -------------------P--D--LY-RLQLSSGD-TNGAAEEYD-------------- -------------------E---------------------------------------- --------------------------------------------QAEVSDSAYLGSESAY SECETFTDEDT------------GALVHPELHEDVETDSGIENTLT-------------- --------------------ESED--------------R---------------N----- ---------------------------RFSLGSDL------------------------- --------HG-------------------------N--ALVAVIGGEEEHFEDFGESNS- ----------------ASDLLLAN-------QEEGRAAPEGEGD---------------- ------------------------------------------------------------ --------PE------------PHPHQGSPMHRPQM---------------LLSP----- ------------------------------------------------------------ ------------------------------------------------------------ ----SS-DPFPTSFQSFLQSESLEFFCTHCHKQISRLEDLSTRLHLLEM--NSSSKRLSS KKA--------ARHL--------LQ-----------------S-GG--LDGMSDLSRDIL DLADSDITD--------------------------------------------------- ---------------KVLLLERRVCELEKDSVASEEQHARLRQENLTLVH---------- -------------------------------------------RANALEEQLKEQELHAE ENLQTLARRHRDTLSKLQRERDLEIENL----------------------QARLHQLDEE NSELRSCVPCLRANIERLEE-------EKRKLQDEVDDMSDRLNEETESRRKMSDKLSHE RHSNNKEKENTQEVIEDLRKQLEHLQLFKLETEARRGR-LPGAGLQEYNTHMRENELEQE IRRLK------------------------------------------------------- -----------------------------------------------------QDNRSLK EQNDELNGQIINLSIQGAKSLFTESLSESLASEINNVSRAE------------------- ------------------------------------------------------------ ------------------------------------LMEAIQKQEEINFRLQDYIDRIIV A----IMESNPSILE--------------------VK--- >ENSAMXP00000020097 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M----E----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QVLSS-------------------------------------------------- ---------------------------P-------------------------------- RGHSDWESDQN--SLGFLLL-DM--------------------------------DNEVV T-G------------SSEKAERHQRGESGI------------------------------ -----------------------------VSLSFDDIFQENAFNLDDLFRASRYSGLEQT YPWEQSSECVSPQWD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------RQP--------------------PC----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SQELPDKNH--------CCDAVSADVDT GDLISFSST--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APS P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------THTSISVQETKQ---------------------------------- ----G--------------------LSTQVVDLLQPIVMTDTESPLDGLIKQPP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LEPLL--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------D------------------------------------------------- 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--------------------------------------------TSLALCIESHVQPCDE S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------CAPHLVTDATIAGMSTLQDANT PSASNIESDSTLGVHSTQSPLDLSLDESAAQTVHEGTGLDPLALSGTPP----------- ------------------------------------------------------------ ----------------------------------------------------ESILPGPS TDISLSRSQLNLNAESPCEGDETLEMGGGEVDVLSHVVLKNSVEYDLESSVLSLEDILAL TENVPDQTTPVESTSASKVLLCCETELIIEKSGDTDELCVKNTHTPETPSLGSIPSMSPP DDIP--------------------------------------------------KP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------EPLDSEREAPADSFDALKSQTDSDSTASSETKLDSVSPVIEAV LNISLEPTAET------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------TPETEMVTPD SESQSHNSHCCINDLPRETGN----------EQTINTCSEDILNDVSHTLTSVETLPHSP PLHFQEAPVWLCESDNTSVDYTTQQDGNELDEGTTKNQLPAFQMESENISNGDHNC---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------EYAHTQDAAPDECATPSEPHETN GYAQNVTAEDHLISHDDDVVDDNQNTPHTLIDTAGENIMETNMVDLTTVPMDNSPSSTKE EREDIDNDQEDDHVTHSSQCV--------------------------------------- ------------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SPLDFTPLSAVD---SQLT----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PVGVAVEQG MGGATP---DTDDVREEGE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --TDLPV----------------------------------------------------- ------------------------------------------------------------ -----------------------QCT-----------------QVDLPQIKHTLPSPTLI DSSP----------------------LTDES----------------------------- ------------------------------------------------------------ ---------------------------------------------------------PS- ------------------------------------------------------------ ------------------------------------------------------EVC--- -----------------------------------------------------PPEEICT PLMEENIDV--------------------------------------------------- ------------------------------------------------------------ ---------------LDIPD---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------SNAK---------------------------- ------------------------------------------------------------ --------------------------------------------MALDLCVSSDAAQE-- ---------------GS------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VAAGAVPVA-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TVP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AA--STRDEER----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------LMEAIQKQEEINFRLQDYIDRIIV A----IMESNPSILE--------------------VK--- >ENSPNAP00000027116 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M----E----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----QVLSS-------------------------------------------------- ---------------------------P-------------------------------- RGHSDWESDQN--SLGFLLL-DM--------------------------------DSDVV T-G------------SPKNAERHQRGEPGI------------------------------ -----------------------------VSLSFDEIFQENGFNLDELFRASRYSGLEQT YSWERSSECVSPEWD--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------KQP--------------------P------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------HPQELAVEGCCDA-SGDVDT GDLISFSSS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APS P----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------THISTSMQATRQ---------------------------------- ----G--------------------SPMQDMDLLQPISVADPGCPLDLFIGQLP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LEPLL--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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NSVDTCMVNSTVLMENLPSDSALPAPGSLKCEVMCVQE---------------------- -----------------------------------------------------------E EREDRDNDQ--DQVTHSSESV--------------------------------------- ------------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------S-LDSMPLSGAD---CQLT----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------QVGVVVEQE RRGATL---DSADVSAERE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --TDLPV----------------------------------------------------- ------------------------------------------------------------ -----------------------QCT-----------------QVDLPQVSYTLPNPSQI AESQVE----------------SLLLLRDES----------------------------- ------------------------------------------------------------ ---------------------------------------------------------PS- ------------------------------------------------------------ ------------------------------------------------------GVC--- -----------------------------------------------------PPEETCM ALMEENIDV--------------------------------------------------- ------------------------------------------------------------ ------------------PD---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------SHAE---------------------------- ------------------------------------------------------------ --------------------------------------------MALDLCVSSDAPQD-- ---------------GS------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VADSA------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------VP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TA--APQDEDH----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LRAVFQ--------------------------ALDQDGDGFVRIEEFMEFA------TAY GAE--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTRF LDPSGLGVISFEDFHRGITAISNG--------------------GSD------------- -------------------P--D--LY-RLQLSSAD-ANGAAEEYD-------------- -------------------E---------------------------------------- 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NSELRSCVPCLRANIERLEE-------EKRKLQDEVEDVTDRLNEETESRRKMSDKLSHE RHSNQKEKESTQELIEDLRKQLEHLQLFKLETEARRGR-LPGAGLQEYNTHMRENELEQE IRRLK------------------------------------------------------- -----------------------------------------------------QDNRSLK EQNDELNGQIINLSIQGAKSLFTESLSESLASEINNVSRVE------------------- ------------------------------------------------------------ ------------------------------------LMEAIQKQEEINYRLQDYIDRIIV A----IMESNPSILE--------------------VK--- >ENSEEEP00000006655 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -M----EK---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PQEEDL----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ LRAVFQ--------------------------ALDQDGDGFVRIEEFMEFA------TAY GAE--------------------------------------------------------- ------------------------------------------------------------ --------------QV--------------------------------------KDLTRF LDPSGLGVISFEDFHRGITAISNGASQIFPNSDKLCVCVCVCVQ---------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------QAEVSDSAYLGSESAY SECETFTDEDT------------GALVHPELHEDVETDSGIENTLT-------------- --------------------ENEE--------------R---------------N----- ---------------------------RFSLGADL------------------------- --------HG-------------------------H--TLGPVICGEEEHFEDFGESNSF SEFKFSSLLFSSPVLLSSDL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------FPASFQSFLQSESLEFFCTHCHKQISRLEDLSTRLHLLEM--N-------- ------------RHL--------LQ-----------------S-GG--LDGMSSLSRDVL DLADSDITD--------------------------------------------------- ---------------KVLLLERRVCELEKDSEESEEQHTRLRQENLALVH---------- -------------------------------------------RANALEEQLKEQELGAE ENLQTLTRRHRDTLTKLQRERDLEIENL----------------------QARLHLLDEE NSELRSCVPCLRANIERLEE-------EKRKLQDEMDDVSDRLNEEMESRRKMADKLSHE HHSNQKEKESTQELIEDLRKQLEHLQLFKLEMEARHGR-MPGAGLQEYNTHMRENELEQE IRRLK------------------------------------------------------- -----------------------------------------------------QDNRSLK EQNDELNGQIINLSIQGAKSLFTESLSESLAAEINNVSRAE------------------- ------------------------------------------------------------ ------------------------------------LMEAIQKQEEINYRLQDYIDRIIV A----IMESNPSILE--------------------VK--- >ENSDCDP00000007961 ------------------------------------------------------------ ------------------------------------------------------------ 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