>ENSFCAP00000013563 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------AGA-AAAQEPPL PP---------------------------------------------------------- --LRPRWPRA-------------------------------------------------- -----------------------------------------ALQPPARPRCAGAAA---- ---AAAAAAAAAAAAA-------AAA---------------------------------- ------------------------------------------------------------ -----------------AAAAAAAAAA--------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCNAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFAARRSCID-ESQISVEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQGSSFHMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEGAMSPLEPICMP VTQESG------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DSPNIPGEESG------------------------------- ------------------------------------------------SVSA-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DANQL-----------R------------------------------- ----------------P-----AGSRRAP------------------------------- ------------------------------------------------------------ -------PQLRARSRSDPV-L-HHSAER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRPQL--------------AT------------VTLRR----GL---RCRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAHVP--PSRRQPGLLHLQSCGDLSTFV-PAG------------------------ ---------------------RPRAQRRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSPPRP00000014775 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCNAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFAARRSCID-ESQISVEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQGSSFHMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEGAMSPLEPICMP VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DSPNTPGEESG------------------------------- ------------------------------------------------SMSA-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DANQL-----------R------------------------------- ----------------P-----AGSWRAP------------------------------- ------------------------------------------------------------ -------PQLRARSRSDPV-L-HHSAER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRPQL--------------AT------------VTLRR----GL---RCRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAHVP--PSRRQPGLLHLQSCGDLSTFV-PAG------------------------ ---------------------RPRAQRRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSPTIP00000010327 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCNAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFAARRSCID-ESQISVEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQGSSFHMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEGAMSPLEPICMP VTQETG------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DSPNTPGEESG------------------------------- ------------------------------------------------SVSA-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DANQL-----------R------------------------------- ----------------P-----AGSWRAP------------------------------- ------------------------------------------------------------ -------QQLRARSRSDPV-L-HHSAER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRPQL--------------AT------------VTLRR----GL---RCRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAHVP--PSRRQPGLLHLQSCGDLSTFV-PAG------------------------ ---------------------RPRAQRRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSAMEP00000007353 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------L-------------------------- ------------PLQVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPSCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFAARRSCID-ESQISAEEVGEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VR------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQGSSFHMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEGATSPLEPICMP VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------E------------------------------------------------- ------------------DIPNTPGEEST------------------------------- ------------------------------------------------SMSA-------- ------------------------------------------------------------ ---------------------L-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DANQLPSTRSRRVFPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSLSDPV-L-HHSAER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRPDL--------------AT------------VTLRR----GL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---AQAHVP--PSRRQPGFLHLRSCGDLSTFV-PAG------------------------ ---------------------RPRAERRP------------------------------- ------------------------PR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSUAMP00000021355 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------L-------------------------- ------------PLQVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFAARRSCID-ESQISAEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VR------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQGSSFHMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEGATSPLEPICMP ATQ--G------------------------------------------------------ ------------------------------------------------------------ ----------E------------------------------------------------- ------------------DIPNTPGEEST------------------------------- ------------------------------------------------SMST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DANQLPPTRSRRVLPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSRSDPV-L-HHSAER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRPDL--------------AT------------VTLRR----GL---RSGASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---ARAHVP--PSRRQPGFLHLRSCGDLSTFV-PAG------------------------ ---------------------RPRAERRP------------------------------- ------------------------PR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSUMAP00000029904 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFAARRSCID-ESQISAEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VR------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQGSSFHMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEGATSPLEPICMP ATQ--G------------------------------------------------------ ------------------------------------------------------------ ----------E------------------------------------------------- ------------------DIPNTPGEEST------------------------------- ------------------------------------------------SMST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NANQLPPTRSRRVFPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSRSDPV-L-HHSAER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRPDL--------------AT------------VTLRR----GL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---ARAHVP--PSRRQPGFLHLRSCGDLSTFV-PAG------------------------ ---------------------RPRAERRP------------------------------- ------------------------PR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSCAFP00020034285 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- -----------------------------------------------AAAA-AAAQEPPL PP---------------------------------------------------------- --LRPRWPRA-------------------------------------------------- -----------------------------------------ALQPPARPRC--------- ---------------A-------AAAPAPAPGVLAPPPA--------LSS---------- ------------------------------------------------------------ ---------------RRAAAAAAAAAA--------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLMNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFAARRSCID-ESQISAEEVEEHGRLPDPDDFVPPAPPPSYFATFYSCTPRMNRRM LGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQGSSLHMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEGAMSPLEPICVP VMQ--G------------------------------------------------------ ------------------------------------------------------------ ----------E------------------------------------------------- ------------------DIPNTPGEEST------------------------------- ------------------------------------------------SISI-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DANQLYPMRSRRVFPL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSRSDPV-L-HHSVER-AVPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRPDL--------------AT------------VTLRR----GL---KCRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAHVP--PSRRQPGLLHLRSCGDLSTFV-PAG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-AVEAERPHSLIGVI------------------- ----------------------RETIL >ENSCAFP00000002787 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLMNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFAARRSCID-ESQISAEEVEEHGRLPDPDDFVPPAPPPSYFATFYSCTPRMNRRM LGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQGSSLHMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEGAMSPLEPICVP VMQ--G------------------------------------------------------ ------------------------------------------------------------ ----------E------------------------------------------------- ------------------DIPNTPGEEST------------------------------- ------------------------------------------------SISI-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DANQLYPMRSRRVFPL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSRSDPV-L-HHSVER-AVPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRPDL--------------AT------------VTLRR----GL---KCRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAHVP--PSRRQPGLLHLRSCGDLSTFV-PAG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-AVEAERPHSLIGVI------------------- ----------------------RETIL >ENSVVUP00000005303 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLMNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFAARRSCID-ESQISAEEVEEHGRLPDPDDFVPPAPPPSYFATFYSCTPRMNRRM LGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQGSSLHMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEGAMSPLEPICVP VMQ-AG------------------------------------------------------ ------------------------------------------------------------ ----------E------------------------------------------------- ------------------DIPNTPGEEST------------------------------- ------------------------------------------------SISI-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DANQLHPMRSRRVFPL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSRSDPV-L-HHSVER-AVPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRPDL--------------AT------------VTLRR----GL---RCRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAHVP--PSRRQPGLLHLRSCGDLSTFV-PAG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-AAEAERPHSLIGVI------------------- ----------------------RETVL >ENSMPUP00000009515 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQMFAARRACID-ESQISAEDVEEHGRIPDPEDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSIHVPG------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEGAASPLEPICMP LTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------E------------------------------------------------- ------------------DIPNTPGEEST------------------------------- ------------------------------------------------SIST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DANQLPPTRSRTVFPA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSRSDPV-L-HHSAER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRPDL--------------AA------------VTMRR----GL---RCRAAR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SGAHAL--PPPRRPGFLHLRSCGDLSTCV-PAG------------------------ ---------------------RPRAERRL------------------------------- ------------------------PR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSNVIP00000013160 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------XXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXX-------------------------------------------- -------------------------------------LGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLSEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQMFAARRACID-ESQISAEDVEEHGRIPDPEDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQGSSFHVPG------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEGATSPLEPICMP LTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------E------------------------------------------------- ------------------DIPNTPGEEST------------------------------- ------------------------------------------------SIST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DANQLPPTRSRTVFPA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSRSDPV-L-HHSTER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRPDL--------------AA------------VTLRR----GL---RCRAAR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SGAHAP--PPPRRPGFLHLRSCGDLSTCV-PAG------------------------ ---------------------RPRAERRL------------------------------- ------------------------QR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSPVAP00000016737 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPTKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFAARRSCSD-ESQISAEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VN------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAATRPLETICIP VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DTPNTPGEENA------------------------------- ------------------------------------------------STST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NPNQLHPMRSGRALQP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSVDR-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRPDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLVDYKSYIDTKLLVAKFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SGVHVL--PSRRQPGLLHLQSCGDLSTFV-SAG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSBTAP00000014839 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEELQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFTLCALNALTTTVCLVAAAL RYLQIFAARRSCVD-ESQIPAEEVEEHRRVPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QADQQQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPEVATSPLEPICMP GIQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPATPGEESA------------------------------- ------------------------------------------------SIPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NTNQLCPARSWRALRP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSAER-AVPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRLDL--------------AA------------VTLRR----RL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PMQPST----------------------------------- ------------------------------------------------------------ ---ARALVL--PSRKQPGLLHLRSCGDLSTFV-PAG------------------------ ---------------------RPLAERRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSBIXP00005011463 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------AAA-AAAQEPPL PP---------------------------------------------------------- --LRPRWPRA-------------------------------------------------- -----------------------------------------ALQPPARPRCG-------- ---------------------------AT--GVLAAPPA----LSSRR------------ ------------------------------------------------------------ ---------------------AA-AAA--------------------------------- ---------------GAPGSALLPARLLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFTLCALNALTTTVCLVAAAL RYLQIFAARRSCVD-ESQIPAEEVEEHRRVPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QADQQQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPEVATSPLEPICMP GIQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPATPGEESA------------------------------- ------------------------------------------------SIPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NTNQLCPARSWRALRP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSAER-AVPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRLDL--------------AA------------VTLRR----RL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PMQPST----------------------------------- ------------------------------------------------------------ ---ARALVL--PSRKQPGLLHLRSCGDLSTFV-PAG------------------------ ---------------------RPLAERRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSBIXP00000016323 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------AAA-AAAQEPPL PP---------------------------------------------------------- --LRPRWPRA-------------------------------------------------- -----------------------------------------ALQPPARPRCG-------- ---------------------------AT--GVLAAPPA----LSSRR------------ ------------------------------------------------------------ ---------------------AA-AAA--------------------------------- ---------------GAPGSALLPARLLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFTLCALNALTTTVCLVAAAL RYLQIFAARRSCVD-ESQIPAEEVEEHRRVPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QADQQQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPEVATSPLEPICMP GIQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPATPGEESA------------------------------- ------------------------------------------------SIPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NTNQLCPARSWRALRP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSAER-AVPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRLDL--------------AA------------VTLRR----RL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PMQPST----------------------------------- ------------------------------------------------------------ ---ARALVL--PSRKQPGLLHLRSCGDLSTFV-PAG------------------------ ---------------------RPLAERRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSBBBP00000010738 X----------------------------------------------------------- ------------------------------------------------XXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXX---------------------------------------- ---------------------------------------XXX------------------ -----------------------------------------------------X------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------LSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFTLCALNALTTTVCLVAAAL RYLQIFAARRSCID-ESQIPAEEVEEHRRVPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QADQQQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPEVATSPLEPICMP GIQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPATPGEESA------------------------------- ------------------------------------------------SIPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NTNQLCPARSWRALRP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSAER-AVPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRLDL--------------AA------------VTLRR----RL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PMQPST----------------------------------- ------------------------------------------------------------ ---ARALVL--PSRKQPGLLHLRSCGDLSTFV-PAG------------------------ ---------------------RPLAERRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSBMUP00000002515 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------CM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFTLCALNALTTTVCLVAAAL RYLQIFAARRSCID-ESQIPAEEVEEHRRVPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QADQQQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPEVATSPLEPICMP GIQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPATPGEESA------------------------------- ------------------------------------------------SIPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NTNQLCPARSWRALRP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSAER-AVPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRLDL--------------AA------------VTLRR----RL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA GFL----------------------EQI-------------------------------- -----------M-A-----PMQPST----------------------------------- ------------------------------------------------------------ ---ARALVL--PSRKQPGLLHLRSCGDLSTFV-PAG------------------------ ---------------------RPLAERRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSOARP00000013932 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AA--------------------------------- ---------------GAPGSALLPARLLLSLGLLQLILGCCM---------VALSFGALS LSSSPQGRNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFTLCALNALTTTVCLVAAAL RYLQIFAARRSCID-ESQIPVEEVEEHRRVPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQQQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEVATSPLEPICMP GIQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPTTPGEESA------------------------------- ------------------------------------------------SIPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NTNQLCPARSWRALRP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSAER-AVPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRLDL--------------AA------------VTLRR----RL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PMQPST----------------------------------- ------------------------------------------------------------ ---SRALVL--PSRKQPGLLHLRSCGDLSTFV-PAG------------------------ ---------------------RPLAERRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSTTRP00000000881 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFAARRSCVD-ESQISAEEVEEHRRIPDPDDFVPPVPPPSYFATFYSCTPRTNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQQQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSGAATSPLEPICMP VIQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DSPNTPREEGA------------------------------- ------------------------------------------------AIST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSSQLCPARNRRALQP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------PRTRSKSDPV-L-HHSAER-AVPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRPDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEYMEEAITSA SFL----------------------EQI-------------------------------- -----------M-G-----PMQPST----------------------------------- ------------------------------------------------------------ ---SRALVL--PSRRQPGLLHLRSCGDLSTFV-PAG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSSSCP00000005640 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLAG GPQAGGPG---------------------------------------------------- ------------------------------------------------AAA-TASQEAPL PP---------------------------------------------------------- --LRPRWPRA-------------------------------------------------- -----------------------------------------ALQPPGRPRCA-------- ---------------------------ANAAGVLAAPPA----LSSRR------------ ------------------------------------------------------------ ---------------------AAAAAA--------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEYQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFAARRSCID-ESQISAEEVEEHRRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM AGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQQQQSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEVATSPLELICTP VIQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNTPGEERA------------------------------- ------------------------------------------------SIST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NANQPHPSRSQRALQP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPM-L-HHSTER-AVPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRPDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PMQPSA----------------------------------- ------------------------------------------------------------ ---SRTPVL--PSRRQPGLLHLRSCGDLSTFV-PVG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSEASP00005013756 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------AGA-AAAQEPPL PP---------------------------------------------------------- --LRPRWPRA-------------------------------------------------- -----------------------------------------ALQPPARPRCA-------- -------------------------APAAAAGVLAAPPA----LASRR------------ ------------------------------------------------------------ --------------------AAAAAAA--------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFAARRSCVD-ESQISAEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VAPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------MS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDEEQGSSFQMLE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEASSSLLEPICTP VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNAPGEEST------------------------------- ------------------------------------------------FVST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NTNQLQPARSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRSDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYRSYVDTKLLVARFLEQ-S--CRMSPDIHELVEDIKAVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPSI----------------------------------- ------------------------------------------------------------ ---SRAHVP--PSRRQPGLLHLRSCGDLSTFV-TVG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-A-EAERPHSLIGVV------------------- ----------------------RETVL >ENSECAP00000034622 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------AAA-AAAQEPPL PP---------------------------------------------------------- --LRPRWPRA-------------------------------------------------- -----------------------------------------ALQPPARPRCA-------- -------------------------APAAAAGVLAAPPA----LASRR------------ ------------------------------------------------------------ ----------------------AAAAA--------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFAARRSCVD-ESQISAEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VAPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------MS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDEEQGSSFQMLE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEASSSLLEPICTP VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNAPGEEST------------------------------- ------------------------------------------------FIST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NTNQLQPARSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRSDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYVDTKLLVARFLEQ-S--CRMSPDIHELVEDIKAVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPSI----------------------------------- ------------------------------------------------------------ ---SRAHVL--PSRRQPGLLHLRSCGDLSTFV-TVG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-A-EAERPHSLIGVV------------------- ----------------------RETVL >ENSPANP00000019275 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMAE------------------------------- ------------------------------------------------------------ ---------------------------------------------RSEAAVIPLDPGCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------AIPNIPAEENA------------------------------- ------------------------------------------------SMST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVRPVRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEDR-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYLDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRARTL--PSRRQPGLLHLQSCGDLSTFA-PAG------------------------ ---------------------RPRAERRS------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSMFAP00000019694 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMAE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAMIPLDPGCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------AIPNIPAEENA------------------------------- ------------------------------------------------SMSS-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVRPVRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEDR-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRTSR-C RPRSLIDYKSYLDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRARTL--PSRRQPGLLHLQSCGDLSTFA-PAG------------------------ ---------------------RPRAQRRS------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSMNEP00000033593 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMAE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAMIPLDPGCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------AIPNIPAEENA------------------------------- ------------------------------------------------SMSS-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVRPVRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEDR-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRTSR-C RPRSLIDYKSYLDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRARTL--PSRRQPGLLHLQSCGDLSTFA-PAG------------------------ ---------------------RPRAERRS------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSCATP00000009934 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMAE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAMIPLDPGCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------AIPNIPAEENA------------------------------- ------------------------------------------------SMST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVRPVRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEDR-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-G RPRSLIDYKSYLDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRARTL--PSRRQPGLLHLQSCGDLSTFA-PAG------------------------ ---------------------RPRAERRS------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSCSAP00000004691 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGHIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMAE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAMIPLDPGCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------AIPNIPAEENA------------------------------- ------------------------------------------------SMPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVRPVRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHAEDR-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYLDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRARTL--PSRRQPGLLHLQSCGDLSTFA-PAG------------------------ ---------------------RPRAERRS------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSMMUP00000080602 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQTGGPG---------------------------------------------------- ------------------------------------------------AAA-AAAQEPPL PP---------------------------------------------------------- --LRPRWPRG-------------------------------------------------- -----------------------------------------ALQPPSRPRCA-------- -------------------------A-TAAAGVLAAPPA----LSSRR------------ ------------------------------------------------------------ --------------------AAAAAAA--------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMAE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAMIPLDPGCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------AIPNIPAEENA------------------------------- ------------------------------------------------SMSS-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVRPVRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEDR-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRTSR-C RPRSLIDYKSYLDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRARTL--PLRRQPGLLHLQSCGDLSTFA-PAG------------------------ ---------------------RPRAERRS------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSTGEP00000030322 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -XX------XXXXXXXXXXXXXXXXXXXXXXXXXXXX---------------XXXXXXXX XXLRPRWPRG-------------------------------------------------- -----------------------------------------ALQPPSRPRCA-------- -------------------------A-TAAAGVLAAPPA----LSSRR------------ ------------------------------------------------------------ --------------------AAAAAAA--------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMAE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAMIPLDPGCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------AIPNIPAEENA------------------------------- ------------------------------------------------SMST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVRPVRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEDR-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYLDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRARTL--PSRRQPGLLHLQSCGDLSTFA-PVG------------------------ ---------------------RPRAERRS------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSMLEP00000035553 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMAE------------------------------- ------------------------------------------------------------ ---------------------------------------------RSEAAVIPLDPGCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------AIPNIPAEENA------------------------------- ------------------------------------------------SMST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVRPVRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEDR-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-G RPRSLIDYKSYLDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRARTL--PSRRQPGLLHLQSCGDLSTFA-PAG------------------------ ---------------------RPRAERRS------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSCANP00000010501 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMAE------------------------------- ------------------------------------------------------------ ---------------------------------------------GAEAAMIPLDPGCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------AIPNIPAEENA------------------------------- ------------------------------------------------SMST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GSTLVRPMRTRRALPA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYLDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRARTL--PSRRQPGLLHLQSCGDLSTFT-PAG------------------------ ---------------------RPRVERRS------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSPTEP00000043292 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------XX---- ------------------------------------------------------------ ----------------------------------XXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXX--------------------------------------- -----------------------------------------XX----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------PPSRPRCA-------- -------------------------A-TAAAGVLATPPA----LSSRR------------ ------------------------------------------------------------ --------------------AAAAAAA--------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMAE------------------------------- ------------------------------------------------------------ ---------------------------------------------GAEAAMIPLDPGCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------AIPNIPAEENA------------------------------- ------------------------------------------------SMST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GSTLVRPMRSRRALPA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYLDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRACML--PSRRQPGLLHLQSCGDLSTFT-PAG------------------------ ---------------------RPRVERRS------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSRBIP00000042601 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMAE------------------------------- ------------------------------------------------------------ ---------------------------------------------GAEAAMIPLDPGCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------AIPNIPAEENV------------------------------- ------------------------------------------------SMST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVRPMRSRRALPA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPQSLIDYKSYLDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRARTL--PSRRQPGLLHLQSCGDLSTFT-PAG------------------------ ---------------------RPRAERRS------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSRROP00000030734 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMAE------------------------------- ------------------------------------------------------------ ---------------------------------------------GAEAAMIPLDPGCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------AIPNIPAEENV------------------------------- ------------------------------------------------SMST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVRPMRSRRALPA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPQSLIDYKSYLDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRARTL--PSRRQPGLLHLQSCGDLSTFT-PAG------------------------ ---------------------RPRAERRS------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSPPAP00000003067 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MEPEALKFKIV-------- -------------------ILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMSE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAVIPLDLGCTQ VTQ--D------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNIPAEENA------------------------------- ------------------------------------------------STST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVRPIRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAHML--PSRRQPGLLHLQSCGDLHTFT-PAG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSGGOP00000010950 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMSE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAVIPLDLGCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNIPAEENA------------------------------- ------------------------------------------------STST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVHPIRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRVSR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAHML--PSRRQPGLLHLQSCGDLHTFT-PAG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-M-EAERPHSLIGVI------------------- ----------------------RETVL >ENSPPYP00000021588 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAVIPLDPGCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNIPAEENA------------------------------- ------------------------------------------------STST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVRPMRNRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAHML--PSRRQPGLLHLQSCGDLHTFT-PAG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSPTRP00000035903 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMSE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAVIPLDLGCTQ VTQ--D------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNIPAEENA------------------------------- ------------------------------------------------STST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVRPIRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAHML--PSRRQPGLLHLQSCGDLHTFT-PAG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSP00000304435 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------AAA-AAAQEPPL PP---------------------------------------------------------- --LRPRWPRG-------------------------------------------------- -----------------------------------------ALQPPSRPRCA-------- -------------------------A-TAAAGVLAAPPA----LSSRR------------ ------------------------------------------------------------ --------------------AVAAAAA--------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEAEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMSE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAVIPLDLGCTQ VTQ--D------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNIPAEENA------------------------------- ------------------------------------------------STST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVRPIRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HPSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAHKL--PSRRQPGLLHLQSCGDLHTFT-PAG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSNLEP00000000791 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAVILLDPGCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNILAEENA------------------------------- ------------------------------------------------SMST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVRPMRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEHSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAHML--PSRRQPGLLHLQSCGDLHTFT-PVG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSCJAP00000003021 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------AAA-AAAQEPPL PP---------------------------------------------------------- --LRPRWPRG-------------------------------------------------- -----------------------------------------ALQPPARPRCT-------- -------------------------A-AAAAGVLAAPPA----LTSRR------------ ------------------------------------------------------------ ---------------------AAAAAA--------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAVIPLDLCCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNIPAEENA------------------------------- ------------------------------------------------SMPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVCPVRSHRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPM-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPQSLIDYRSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAHTL--PSRRQPGLLHLQSCGDLSTFT-PAG------------------------ ---------------------RPQAERRP------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSCCAP00000007439 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAVIPLDPCCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNIPAEENA------------------------------- ------------------------------------------------SMPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVCPVRSHRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPM-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRTHML--PSRRQPGLLHLQSCGDLSTFT-PVG------------------------ ---------------------RPQAERRP------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSANAP00000005929 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEDVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAVIPLDPCCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNIPAEENA------------------------------- ------------------------------------------------SMPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVCPARSHRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPM-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPST----------------------------------- ------------------------------------------------------------ ---SRAHTL--PSRRQPGLLHLQSCGDLSTFT-PAG------------------------ ---------------------RPHAERRP------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSSBOP00000008306 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGHIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMNQEQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAAIPLDPCCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNIPAEENA------------------------------- ------------------------------------------------SMPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVCPVRSHRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPM-L-HHSEER-AVPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYMDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAHTL--PSQRQAGLLHLQSCGDLSTFT-PAG------------------------ ---------------------RPQAERRP------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSTSYP00000000903 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHGRIPDPEDFVPPVPPPSYFATFYSCTPRMNRRM VGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QRDCEQGPSFQIPE------------------------------- ------------------------------------------------------------ ---------------------------------------------ESEAVVSPLEPVCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPSTPGEEST------------------------------- ------------------------------------------------SIST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NSTLVRPMRSRRTLPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LSTRSKSDPV-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-T-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAHAL--PSRRQPGLLHLQSCGDLSTFI-PVG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSPSMP00000037495 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------ILL------ ------------------------------------------------------------ ---------------VNLFVLLSVVCVLLNLAGFILGFQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCVD-ESQISTEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPWMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMHQEQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAASPLEPVCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNTPGEGST------------------------------- ------------------------------------------------SIST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVQPVRSRRALPA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSQDR-AAPV--------LSS---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLPPSS----------------------------------- ------------------------------------------------------------ ---SRALAL--PWRRRPGLLHLRSCGDLSTFT-PAG------------------------ ---------------------RPQAQRRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSPCOP00000018428 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------ILL------ ------------------------------------------------------------ ---------------VNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCVD-ESQISVEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRT VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTHREQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAASPLEPVCTQ ATQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNTPGEEST------------------------------- ------------------------------------------------SIST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVQPVRSRRALPA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEDR-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYKSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPGT----------------------------------- ------------------------------------------------------------ ---SRVHAL--PSRRRPGLLHLRSCGDLSTFA-PAG------------------------ ---------------------RPQAQRRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSMICP00000031309 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------VALSFGALS LSSSPQVKNSCPFWAGS------------------------------------------- --------------SVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCVD-ESQISVEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMHQEQGSPFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAATSPLEPVCTQ VVQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNTPGEEST------------------------------- ------------------------------------------------SIST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSSLAQPVRSRRALPA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEDR-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLIDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPGA----------------------------------- ------------------------------------------------------------ ---SRALAP--PSRRRPGLLHLRSCGDLSTFA-PAG------------------------ ---------------------RPQARRRP------------------------------- ------------------------RRQA-EAERPHSLIGVV------------------- ----------------------RETVL >ENSOGAP00000006091 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------L---------PFQ------ ------------------------------------------------------------ ---------------VNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCVD-ESQISTEEVEEHGHIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAESLLEPVCTQ GTC--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DLPNTPGEEST------------------------------- ------------------------------------------------SIST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSTLVHPVRSRRALPA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RSRASR-C RPRSLVDYKSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PPQPST----------------------------------- ------------------------------------------------------------ ---SRAHVL--PSRRRPGLLHLQSCGDLSTFT-PAG------------------------ ---------------------RPRAEGRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSUPAP00010029879 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------AAA-AAAQDTPL PP---------------------------------------------------------- --LRPRWTRG-------------------------------------------------- -----------------------------------------ALQPPARPRCA-------- -------------------------A--AAAGVLTAPPA----LSSRR------------ ------------------------------------------------------------ --------------------AAAAAAA--------------------------------- ---------------APPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQMSAEDVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDIIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQIPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAASPLEPVCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DISNTPGEESTPTAIPSSHPEH--------PS---------- ----------------R-----------------------------NW------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------RTLPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RPRASR-C RPRSLIDYKSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PPQPST----------------------------------- ------------------------------------------------------------ ---SRVHTL--PSRRQPGLLHLRSCGDLSTFV-PAG------------------------ ---------------------RPRVERRP------------------------------- ------------------------SR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSSDAP00000021663 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------PPARPRCA-------- -------------------------A--AAAGVLTAPPA----LSSRR------------ ------------------------------------------------------------ --------------------AAAAAAA--------------------------------- ---------------A-PGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQMSAEDVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM IGPDIIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQIPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAASPLEPVCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DISNTPGEESTPTAIPSSHPEH--------PS---------- ----------------R-----------------------------NW------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------RTLPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RPRASR-C RPRSLIDYKSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PPQPST----------------------------------- ------------------------------------------------------------ ---SRVHTM--PSRRQPGLLHLRSCGDLSTFV-LAG------------------------ ---------------------RPRVERRP------------------------------- ------------------------SR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSHGLP00100009554 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MPGSWQGSAGTPGPASLRGKGARVXXX------ --------------XAAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLDEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISVEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QRDQEQGSSFQVPE------------------------------- ------------------------------------------------------------ ---------------------------------------------TSEAAASPLEPVCMQ ATQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPSTPGEEST------------------------------- ------------------------------------------------SIPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NSNRVHPTRSWRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-AIPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDV--------------AS------------VTLRR----GS---RPRVSR-C RPRSLVDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPST----------------------------------- ------------------------------------------------------------ ---SQAHVP--PLRSQPGLLHLRSCGDLSTFAAPVG------------------------ ---------------------RPRSSRRP------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSHGLP00000019709 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------RPR---------- ----------------------------AVPGVLGAPPT----LSARR------------ ------------------------------------------------------------ ---------------------AAAAAA--------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLDEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISVEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QRDQEQGSSFQVPE------------------------------- ------------------------------------------------------------ ---------------------------------------------TSEAAASPLEPVCMQ ATQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPSTPGEEST------------------------------- ------------------------------------------------SIPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NSNRVHPTRSWRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-AIPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDV--------------AS------------VTLRR----GS---RPRVSR-C RPRSLVDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPST----------------------------------- ------------------------------------------------------------ ---SQAHVP--PLRSQPGLLHLRSCGDLSTFAAPVG------------------------ ---------------------RPRSSRRP------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSODEP00000005777 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AAAAA--------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEELQPSKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-DSQISVEEAEDHGRIPDPDDFVAPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QVDQEQGSSRQAPE------------------------------- ------------------------------------------------------------ ---------------------------------------------ASEAAASPSEPVCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNTPGEESA------------------------------- ------------------------------------------------SIPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSNPAHPTRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRTKSDPV-L-HHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RPKASR-C RPRSLIDYRSYIDTKLLVARFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPSA----------------------------------- ------------------------------------------------------------ ---TQAPVP--PSRSQPSLLHLRSCGDLSTFACPAG------------------------ ---------------------RPRSSRRP------------------------------- -----------------------LRR-A-EADRPHSLIGVI------------------- ----------------------RETVL >ENSCLAP00000010878 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPTKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISVEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QVDQEQGSSFQVPE------------------------------- ------------------------------------------------------------ ---------------------------------------------ASEAAASPLEPVCTH VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNTPGEEST------------------------------- ------------------------------------------------SIPP-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NSSPAHPARSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRTKSDPV-L-HHSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RPRASR-C RPRSLIDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPST----------------------------------- ------------------------------------------------------------ ---AQAPAP--PSRNQPGLLHLRSCGDLSTFASPVG------------------------ ---------------------RPRSSRRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSFDAP00000011351 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------CM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISVEEVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQVPE------------------------------- ------------------------------------------------------------ ---------------------------------------------ISEAAASPLEPVGTQ ATQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DISSTPGEESA------------------------------- ------------------------------------------------SLPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NSNPVHPARSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHPEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDV--------------AA------------VTLRR----GL---RPRAPR-Y RPRSLIDYRSYTDTKLLVAKFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPST----------------------------------- ------------------------------------------------------------ ---SQAHVL--PLRSQPGLLHLWSCGDLSTFTPPMG------------------------ ---------------------RPRSSRRP------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSCPOP00000002931 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------PGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFTTRRSCID-ESQISVEEVEDHGRIPDPEDFIPPVPPPSYFATFYSCTPRMSRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QVDQEQGSSCQVPE------------------------------- ------------------------------------------------------------ ---------------------------------------------VSEAAASPLEPVCMQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNTPGEEST------------------------------- ------------------------------------------------SIPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SLNPAHPPGARRVLPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RPRASR-C RPRSLIDYRSYIDTKLLVARFLEQSS--CSMAPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQV-------------------------------- -----------M-A-----PSQPGF----------------------------------- ------------------------------------------------------------ ---SQTPVPPSPSRIQPGLLHLRSCGDLSTFALPMG------------------------ ---------------------RPRTSRRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSLAFP00000000900 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------VNLFVLLSVVCVLLNLAGFILGCQGAQFVASVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMSRRV VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSCQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAASPSEPVCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNTPGEESP------------------------------- ------------------------------------------------SVST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NSSLVHPARSRRPFQP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSAET-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRLDL--------------AA------------VTLRR----GL---RSRALR-S RPRSLIDYKSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EEI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---ARVHAL--PSRRQPGLLHLQSCGDLSTFA-PAG------------------------ ---------------------RPRVERRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSSTOP00000011356 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ --------------------YDTLYALEFFGGKRCQERPQRPDRSPPSDRLGPRNVSAGN HLALVVQAP--------------------------------RS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQMSAEDVEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDIIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQIPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAARPLEPVCTQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------EISNTTGEESTPTAIPSSHPE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------HPSRNWRTLPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSRSDPV-L-HHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GL---RPRASR-C RPRSLIDYKSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PPQPST----------------------------------- ------------------------------------------------------------ ---SRVHTL--PSRRQPGLLHLRSCGDLSTFV-PAG------------------------ ---------------------RPRVERRP------------------------------- ------------------------SR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSCCNP00000009886 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------TVA-AACQEPPL PP---------------------------------------------------------- --LRPRWPRG-------------------------------------------------- -----------------------------------------ALQPPVRPRCA-------- -------------------------ATATATGVLAPPPA----LASRR------------ ------------------------------------------------------------ ---------------------ATTAAA--------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEYQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEVEDHSRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM IGSDIIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GTEAAASPSEPVCIQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------E------------------------------------------------- ------------------DISNTPVEEST------------------------------- ------------------------------------------------SVLT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSNPVPPSRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-CHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GM---RPRASR-C RPRSLIDYKSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPST----------------------------------- ------------------------------------------------------------ ---SWAHTA--PSRRQPGLLHLWSCGDLSTFA-PVG------------------------ ---------------------RPSVERRP------------------------------- ------------------------RR-A-EAERPHSLIGVV------------------- ----------------------RETVL >ENSJJAP00000020472 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------APGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-EAQISAEEVEDHGRIPGPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQDQGSSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPEATANPLEPVCIQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DVPNTPGEE--------------------------------- ------------------------------------------------SVST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSNLVHPPRSRKAFPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEDR-AIPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDV--------------AA------------VTLRR----GP---RPRTSR-G RPRSLVDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PAQPST----------------------------------- ------------------------------------------------------------ ---SQAHTL--PSRTQAGLLHLRSCGDLSTFA-LVG------------------------ ---------------------MPRAERRP------------------------------- -----------------------RRR-A-EAERPHSLIGVV------------------- ----------------------RETVL >ENSMUSP00000093878 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------AATAAAAQEPPL PP---------------------------------------------------------- --LRPRWPRG-------------------------------------------------- -----------------------------------------ALQPPARPRCAPAA----- --------------------------------VLAPPPA----LASRR------------ ------------------------------------------------------------ ----------------------------P------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFASRRPCID-ESQMSAEDVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQESSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPETAASPAEPVCTQ ITQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------ALTNTTGEENT------------------------------- ------------------------------------------------SGST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ILTLVQPPRSRRALPL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AT------------VTLRR----GA---RPRASR-C RPRSLIDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEGHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPST----------------------------------- ------------------------------------------------------------ ---SQAQEL--SWRRQPGLLHLRSCGDLSTFS-LTA------------------------ ---------------------RPRAERRP------------------------------- -----------------------QQR-A-EAERPHSLIGVI------------------- ----------------------RETVL >MGP_SPRETEiJ_P0050402 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------AATAAAAQEPPL PP---------------------------------------------------------- --LRPRWPRG-------------------------------------------------- -----------------------------------------ALQPPARPRCAPAA----- --------------------------------VLAPPPA----LASRR------------ ------------------------------------------------------------ ----------------------------P------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFASRRPCID-ESQMSAEDVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQESSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPETAASPAEPVCTQ ITQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------VLTNTTGEENT------------------------------- ------------------------------------------------SGST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------IPTLVQPPRSWRALPL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AT------------VTLRR----GA---RPRASR-C RPRSLIDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEGHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPST----------------------------------- ------------------------------------------------------------ ---SQAQEL--SWRRQPGLLHLRSCGDLSTFS-LTA------------------------ ---------------------RPGAERRP------------------------------- -----------------------QQR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSMSIP00000012943 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------AATAAAAQEPPL PP---------------------------------------------------------- --LRPRWPRGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----------X------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------VILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFASRRPCID-ESQMSAEDVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQESSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPETAASPAEPVCTQ ITQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------VLTNTTGEENT------------------------------- ------------------------------------------------SGST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------IPTLVQPPRSRRALPL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AT------------VTLRR----GA---RPRASR-C RPRSLIDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEGHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPST----------------------------------- ------------------------------------------------------------ ---SQAQEL--SWRRQPGLLHLRSCGDLSTFS-LTA------------------------ ---------------------RPRAERRP------------------------------- -----------------------QQR-A-EAERPHSLIGVI------------------- ----------------------RETVL >MGP_CAROLIEiJ_P0048409 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------AATAAAAQEPPL PP---------------------------------------------------------- --LRPRWPRG-------------------------------------------------- -----------------------------------------ALQPPARPRCAPAA----- --------------------------------VLAPPPA----LASRR------------ ------------------------------------------------------------ ----------------------------P------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFASRRPCID-ESQMSAEDVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQESSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPETAASPAEPVCTQ ITQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------VLTNTTGEENT------------------------------- ------------------------------------------------SGST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ISNLVQPPRSRRALPL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AT------------VTLRR----GA---RPRASR-C RPRSLIDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEGHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSLPST----------------------------------- ------------------------------------------------------------ ---SQAQEL--SLRRQPGLLHLRSCGDLSTFS-LAA------------------------ ---------------------RPRAERRP------------------------------- -----------------------QQR-A-EAERPHSLIGVI------------------- ----------------------RETVL >MGP_PahariEiJ_P0021380 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------AATAAAAQEPPL PP---------------------------------------------------------- --LRPRWPRG-------------------------------------------------- -----------------------------------------ALQPPARPRCAPAA----- --------------------------------VLAPPPA----LASRR------------ ------------------------------------------------------------ ----------------------------P------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFASRRPCID-ESQMSAEDVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTDQEQESSFQMLE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPETASSPAEPVCSQ ITP--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------VLTNTTSEENT------------------------------- ------------------------------------------------SGPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ISSLVQPPRSRGALPL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPG-L-HHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AT------------VTLRR----GA---RPRASR-Y RPRSLIDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEGHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPSA----------------------------------- ------------------------------------------------------------ ---SQAQEL--SWRRQPGLLHLRSCGDLSTFS-LAG------------------------ ---------------------RRRAERRP------------------------------- -----------------------QQR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSRNOP00000072580 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFASRRPCID-ESQISAEEVEEPGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QADQEQESSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPETAASPVEPVCTQ ITR--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------VLTNTPAEENT------------------------------- ------------------------------------------------SGST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LSNVVQPPRSRRALPL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPM-L-HHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AT------------VTLRR----GA---RPRASR-C RPHSLIDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEGHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PAQPST----------------------------------- ------------------------------------------------------------ ---SQAQML--TSRRQPGLLHLRSCGDLSTFS-LAG------------------------ ---------------------RPRAERRL------------------------------- -----------------------QQR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSCGRP00001002200 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------VAT-TAAQEPPL PP---------------------------------------------------------- --LRPRWPRG-------------------------------------------------- -----------------------------------------ALQPPARPRCAPAA----- --------------------------------VLAPPPA----LASRR------------ ------------------------------------------------------------ ----------------------------P------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFASRRPCID-ESQMSAEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQESSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPEAAASPSEPVCTQ ITQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------VLPNPTGEENI------------------------------- ------------------------------------------------SAST-------- ------------------------------------------------------------ ---------------------A-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ISNLVQPPRSQRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPL-L-HHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GV---RPRASR-C RPHSLIDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PPQPST----------------------------------- ------------------------------------------------------------ ---SQAHVL--TSRRQPGLLHLHSCGDLSTFS-LAG------------------------ ---------------------RPKEERRP------------------------------- -----------------------QHR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSCGRP00015002433 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------VAT-TAAQEPPL PP---------------------------------------------------------- --LRPRWPRG-------------------------------------------------- -----------------------------------------ALQPPARPRCAPAA----- --------------------------------VLAPPPA----LASRR------------ ------------------------------------------------------------ ----------------------------P------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFASRRPCID-ESQMSAEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQESSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPEAAASPSEPVCTQ ITQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------VLPNPTGEENI------------------------------- ------------------------------------------------SAST-------- ------------------------------------------------------------ ---------------------A-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ISNLVQPPRSQRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPL-L-HHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GV---RPRASR-C RPHSLIDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PPQPST----------------------------------- ------------------------------------------------------------ ---SQAHVL--TSRRQPGLLHLHSCGDLSTFS-LAG------------------------ ---------------------RPKEERRP------------------------------- -----------------------QHR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSMOCP00000020710 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------AAT-AASQEPPL PP---------------------------------------------------------- --LRPRWPRG-------------------------------------------------- -----------------------------------------ALQPPARPRCAPAA----- --------------------------------VLAPPPA----LASRR------------ ------------------------------------------------------------ ----------------------------P------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCNAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFTSRRPCID-ESQMSAEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRLNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QIDQEQESSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPEAAASPLEPVCTQ TTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------VLPNTAGEENT------------------------------- ------------------------------------------------PAPT-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LSNLVQPPRSRRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPL-L-HQSEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLEL--------------AA------------VTLRR----GA---RPRASR-G RPRSLIDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PPQPST----------------------------------- ------------------------------------------------------------ ---SQAHVL--TLRRQPGLLHLRSCGDLSTFS-LAG------------------------ ---------------------RPRSERRP------------------------------- -----------------------QQQ-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSPEMP00000022806 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------XXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------RR------------ ------------------------------------------------------------ ----------------------------P------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFASRRPCID-ESQMSVEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLEPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QIDQEQESSFQTLE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPEAGARPLEPVCTQ ITP--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------VLPNTTGEENT------------------------------- ------------------------------------------------SAST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------VSNLVPPPRSRRAFPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSRSDPL-L-HHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTDRRLDL--------------AA------------VTLRR----GV---RPRASR-C RPRSLIDYRSYIDTKLLVARFLEQTS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPST----------------------------------- ------------------------------------------------------------ ---SQAHVL--TSRRQPGMLHLRSCGDLSTFS-LAG------------------------ ---------------------RPRAQRRP------------------------------- -----------------------QQR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSMAUP00000008898 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------PPA----LASRR------------ ------------------------------------------------------------ ----------------------------P------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSS------------------------------------------ ---------------VNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRPCID-ESQMSTEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMGQEQESSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPEAAASPSEPVCTQ ITQ--G------------------------------------------------------ ------------------------------------------------------------ ----------GA-----------------------P------------------------ ---PN------------P--PNTDGEEST------------------------------- ------------------------------------------------SAST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------VSNLMQPPRSQRALPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPL-L-HHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GV---RPRTSR-C RPRSLIDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PPQPST----------------------------------- ------------------------------------------------------------ ---SQAHVL--TSRRQPGLLHLRSCGDLSTFS-LTG------------------------ ---------------------RPREERRP------------------------------- -----------------------QQR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSMUGP00000017290 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSG GPQAGGPG---------------------------------------------------- ------------------------------------------------TAA-AAAQEPPL PP---------------------------------------------------------- --LRPRWPRG-------------------------------------------------- -----------------------------------------ALQPPARPRCAPAA----- --------------------------------ALAPPPA----LASRR------------ ------------------------------------------------------------ ----------------------------P------------------------------- ---------------AAPGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFASRRPCVD-ESQMSAEEVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QIGQDQESSFQMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GPEAAASPLEPVCTQ ISQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------VLPNATGDENT------------------------------- ------------------------------------------------SVST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------VSTLVPPPRSRRAFRP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRARSKSDPV-L-RHSEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRR----GA---RPRASR-C RPRSLIDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPSTAH--------------------------------- ------------------------------------------------------------ -VLSSTHVL--TSRRQPGLLHLRSCGDLSTFS-LAG------------------------ ---------------------RPRAERRP------------------------------- -----------------------QQR-A-EADRPHSLIGVI------------------- ----------------------RETVL >ENSOCUP00000011613 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-EAQISAEELEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRLSRRM AASDIIPVPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDREQGPAFRIPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GTETATSPLEVVCAQ VTQ--G------------------------------------------------------ ------------------------------------------------------------ ----------E------------------------------------------------- ------------------DIPSTPGEEST------------------------------- ------------------------------------------------SLST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NSNLGPPGRSRRAPPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRARSKSDPV-L-HHCEER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AA------------VTLRT----GL---RPRASR-G RPRSLIDYRSYMDTKLLVARFLEQSS--CRMAPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAQAL--PSRRQPGLLHLLSCGDLSTFA-PVG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-A-EAERPHSLIGVV------------------- ----------------------RETVL >ENSDNOP00000003747 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AA--------------------------------- ---------------GAAGSALLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISVEEVEEHGRIADPDDFVPPVPPPSYFSTFYSCTPRMNRRM VGADVIPLPHIYGARFKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QPGPEQGSSFRMPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAVESPSEPIYAQ VTQ--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----EISG---------TDIPNTPGEEST------------------------------- ------------------------------------------------SMSP-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NSNLVHPARSHRAFQP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHSTDR-APPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRLEL--------------AA------------VTLRR----GL---RPRALR-S RPRSLIDYKSYIDTKLLVARFLEQSS--CSMAPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPST----------------------------------- ------------------------------------------------------------ ---SRAPML--PSRRQPGLLHLRSCGDLSTFA-LPG------------------------ ---------------------RPRAERRP------------------------------- ------------------------RR-A-EAERPHSLIGVI------------------- ----------------------RETVL >ENSDORP00000001463 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------RPLLSLGLLQLVLGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENSLKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFTTRRSCID-ESQISAEEVEDHGRIPDPDDFIPPVPPPSYFATFYSCTPRMSRRM AGPDVIPLPHIYGARSKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QMDQEQGSSFQIPE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAAVSPLEP---- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------ADTHTTQGGAVPPTAGEEVTSVLSP PASL-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------VHPARSCRAFPP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRTRSKSDPV-L-HHCEER-ATPV--------LSC---------------- ----------------------------------------------------------EA ATQTERRLDL--------------AL------------VTLRR----SS---RPRALR-C RPRSLIDYRSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PSQPSA----------------------------------- ------------------------------------------------------------ ---AWAYTL--PWQRRPGLLHLQSCGDLSTFA-PPG------------------------ ---------------------RLRAERRP------------------------------- ------------------------RR-V-EAERPHSLIGVI------------------- ----------------------RETVL >ENSMLUP00000007087 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------ALLPGRPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENVLKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYVQIFAARRSCSE-ESQISAEEVEEQGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRM VGPDVIPLPHIYGARIKGVEVFCPLDLPPPYEAV-------------------------- ---------------------------------------------VN------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------ETEREQTSSFQISE------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAATSPMEPIGVP VTQ--D------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------NIPNTPGEESA----------STSVANSDQP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------HPGRSRRALQP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------TMTRSKSDPV-F-HPSAER-AAPV--------LSC---------------- ----------------------------------------------------------EA ATQTEGRPDL--------------AA------------VTLRR----GL---RPRAAR-C RPQSLIDYKSYIDTKLLVARFLEQSS--CAMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-A-----PLQPSP----------------------------------- ------------------------------------------------------------ ---PRAHLL--PSRRQPGVLHLWSCGDLSTFV-AAG------------------------ ---------------------RPRVERRP------------------------------- ------------------------RR-A--AERPHSLIGVI------------------- ----------------------RETVL >ENSMEUP00000004416 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------VNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPTKCTDKENVLKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRPCID-ESQISTEEIEGHGRIPDLEDFVPPVPPPSYFATFYSCTPRMNRRM IGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QISQEQGTSLQIPE------------------------------- ------------------------------------------------------------ ---------------------------------------------ASEAVAGPLDPGSAQ VSQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNTPGEESP------------------------------- ------------------------------------------------SLST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DSNLVHLPSNRRALQP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRARSKSDPV-L-HHLTAR--GPV--------LSC---------------- ----------------------------------------------------------EA ATQTEVRTEL--------------AP------------VTFRK----GL---RARAIR-A RPRSLVDYKSYIDTKLLVAKFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA NFL----------------------EQI-------------------------------- -----------M-T-----PAQPST----------------------------------- ------------------------------------------------------------ ---SRAQML--PYRRHPRLLHLESCGDLSTFA-SAE------------------------ ---------------------SQRVERRI------------------------------- ------------------------PR-T-DPERPHSLIGVV------------------- ----------------------RETVL >ENSMODP00000003485 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSA GTQVGGPGA--------------------------------------------------- -------------A--AAA---------------------------AAAAA-AAAQEPPL AP---------------------------------------------------------- --LRPRWSRA-------------------------------------------------- -----------------------------------------GLQPPVRPRCAAPSASSVL SPPP---------------------------------PP----LSARR------------ ------------------------------------------------------------ -------------------AAAAAAAA--------------------------------- ---------------GVPGSGLLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPTKCTDKENVLKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFVTRRPCID-ESQISTEEIEGHGRIPDPEDFVPPVPPPSYFATFYSCTPRMNRRM VGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------MS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QINQEQGTSFQIPE------------------------------- ------------------------------------------------------------ ---------------------------------------------ESEAGAGPLDPVSAQ VSQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNTPGEESP------------------------------- ------------------------------------------------SLST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DSNLAHLPSNRRTLQP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRARSKSDPV-L-HHLTAR--GPV--------LSC---------------- ----------------------------------------------------------EA ATQTEVRPAL--------------AP------------VTLRK----GL---RARAVR-A RPRSLVDYKSYIDTKLLVAKFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-T-----PDQPST----------------------------------- ------------------------------------------------------------ ---SRAQPL--PYRRHPGLLHLESCGDLSTFA-SAE------------------------ ---------------------SRRVERRV------------------------------- ------------------------PR-T-DPERPHSLIGVV------------------- ----------------------RETVL >ENSPCIP00000041500 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSA GTQAGGPG---------------------------------------------------- ------------------A---------------------------AAAAA-AAAQEPPL AP---------------------------------------------------------- --LRPRWSRA-------------------------------------------------- -----------------------------------------GLQPPARPRCAAASAASVL SPPQ---------------------------------PP----LSARR------------ ------------------------------------------------------------ -------------------AAAAAAAA--------------------------------- ---------------GVPGSGLLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPTKCTDKENVLKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRPCID-ESQISTEEIEGHGRIPDLEDFVPPVPPPSYFATFYSCTPRMNRRM VGSDVIPLPHIYGARIKGVEVFCPLDPPPPYESV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QINQEQGTSFHIPE------------------------------- ------------------------------------------------------------ ---------------------------------------------ASEAVAGPVDPGSAQ VSQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNTSEEDSP------------------------------- ------------------------------------------------SLST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DSNLAHLPLSRRALQP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRARSKSDPV-L-HHSTAR--GPV--------LSC---------------- ----------------------------------------------------------EA ATQTEVRPQL--------------AP------------VTLRK----GL---QARAVR-A RPRSLVDYKSYIDTKLLVAKFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-T-----PAQPST----------------------------------- ------------------------------------------------------------ ---SRTQML--PYRRHPGLLHLESCGDLSTFV-SAE------------------------ ---------------------KQRVERRV------------------------------- ------------------------PR-T-DPERPHSLIGVV------------------- ----------------------RETVL >ENSVURP00010009447 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSA GTQTGGPG---------------------------------------------------- -----------------------------------------------AAAA-AAAQEPPL AP---------------------------------------------------------- --LRPRWSRA-------------------------------------------------- -----------------------------------------GLQPPARPRCAAASAASVL SPPQ---------------------------------PP----LSARR------------ ------------------------------------------------------------ -------------------AAAAAAAA--------------------------------- ---------------GVPGSGLLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPTKCTDKENVLKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRPCID-ESQISTEEIEGHGRIPDLEDFVPPVPPPSYFATFYSCTPRMNRRM VGSDVIPLPHIYGARIKGVEVFCPLDPPPPYESV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QINQEQGTSFQIPE------------------------------- ------------------------------------------------------------ ---------------------------------------------ASEVVAGPVDPGSAQ VSQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNTSGEESP------------------------------- ------------------------------------------------SLST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DSNLAHLPLNRRALQP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRARSKSDPV-L-HHLTAR--GPV--------LSC---------------- ----------------------------------------------------------EA ATQTEVRPEL--------------AP------------VTLRK----GL---RAQAVR-A RPRSLVDYKSYIDTKLLVAKFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-T-----PVQPST----------------------------------- ------------------------------------------------------------ ---SRAQML--PYRRHPGLLHLESCGDLSTFA-SVE------------------------ ---------------------NRRVERRV------------------------------- ------------------------PR-T-DPERPHSLIGVV------------------- ----------------------RETVL >ENSSHAP00000010349 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------A-TAAQEPPL AP---------------------------------------------------------- --LRPRLSRA-------------------------------------------------- -----------------------------------------GLQPPARPRCAVASAPSVL SPLQ---------------------------------PP----LSSRQ------------ ------------------------------------------------------------ ---------------------AASAAA--------------------------------- ---------------GVSGSGLLPARPLLSLGLLQLILGCCM---------VALSFGALS LSSSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVICVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFHPIKCTDKENVLKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRPCID-ESQISTEEIEGHGRIADLEDFIPPVPPPSYFATFYSCTPRMNRRM VGVDVIPLPHIYGARIKGVEIFCPLDPPPPYEAV-------------------------- ---------------------------------------------VN------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QINQEQGTSFQSPE------------------------------- ------------------------------------------------------------ ---------------------------------------------VSEVVTGSLDPGSAQ VSQ--GNKS--------------------------------------------------- ------------------------------------------------------------ ---------DG------------------------------------------------- ------------------DIPNTPGEESL------------------------------- ------------------------------------------------ALST-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DSNLAHLPSNMKALQP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRARSKSDPV-L-HHLTARAVGPV--------LSC---------------- ----------------------------------------------------------EA ATQTEVRPEL--------------AP------------VNLRK----GL---RTRAVR-A RPHSLIDYKSYTDTKLLVAKFLEQSS--CTMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-T-----PAQPST----------------------------------- ------------------------------------------------------------ ---LR--IL--PCRRYPGLLHLESCGDLSTFV-SAE------------------------ ---------------------SQKVKRRV------------------------------- ------------------------PR-T-DPERPHSLIGVV------------------- ----------------------RETVL >ENSOANP00000004994 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------FFFQ------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------VNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGEG KICFCCEEFQPAKCTDKENVLKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRPCID-ESPFSAEEVEEQGHIPDPEDFVPPVPPPSYFATFYSCTPRMSRRM VGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QINQEQGTAFQIPE------------------------------- ------------------------------------------------------------ ---------------------------------------------VAEAVAGPLEPLSRQ VPQ--G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------DIPNARERESP------------------------------- ------------------------------------------------ALPN-------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DSNPAPLPASRRACQP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRVRSKSDPV-L-HHLPAR-VGPV--------LSC---------------- ----------------------------------------------------------EA ATQTEVRLEL--------------AP------------VTLRK----GL---RTRALR-A RPRSLVDYKSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQI-------------------------------- -----------M-T-----PAGPGT----------------------------------- ------------------------------------------------------------ ---SRTQML--PYRRHAGLLHLESCGDLSTFT-SAE------------------------ ---------------------NQRVERRP------------------------------- ------------------------QR-T-EPERPHSLIGVV------------------- ----------------------RETVL >ENSPSIP00000012809 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------VNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDLLKVDLGES KICFCCEEFHPAKCTEKENALKLYPVQSCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQVSVEDVEEQGRISDPEDFVPPVPPPSYFATFYSCTPRTNRRM LGADIIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTSCEQGGAFQIPDVAEAVVRPPEPN------------------- ------------------------------------------------------------ ----------------------------DIQVSQ-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------VG------------------------------------------------- ---------------------------------------------ADIPDSSSRESLSTS NLSSVPVEQKPAR---K------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------RAFNP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRKRSKSDPM-L-HGLPPR-ACPV--------LSC---------------- ----------------------------------------------------------EA ATQTELKPKL--------------AT------------VILRR----GL---RARALR-A RPRSLVDYKSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQV-------------------------------- -----------M-T-----PAQPST----------------------------------- ------------------------------------------------------------ ---SRAHTL--PFRRHPGLLHLESCGDLSTFT-TSE------------------------ ---------------------NQVAERRT------------------------------- ------------------------QR-L-EHERPHSLIGVV------------------- ----------------------RETVL >ENSCPBP00000036468 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPMAGLSA ALQAAAPGPATS------------------------------------------------ --------PA-----------------------------------------------PPL PPLRRFQHYR-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------PPPAALSPLSARR------------ ------------------------------------------------------------ -----------------------AAAA--------------------GAH---------- --------------------GLLPARPLLSLGLLQLILGCCM---------VALSFGALS LSGSPQVKNSCPFWAGSSVILSGIIGLTTWKRPV-------------------------- ------------VLLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGES KICFCCEEFHPAKCTEKENALKLYPVQSCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQVSVEEIEEQGRISDPEDFVPPVPPPSYFATFYSCTPRMNRRM LGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QISREQGGAFQIPDVAEAVVGPPEPN------------------- ------------------------------------------------------------ ----------------------------DTQVSQ-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------VG------------------------------------------------- ---------------------------------------------GDIPDSSNRESLSTS NPSSVPAEQKPAC---K------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------RAFNP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRKRSKSDPV-L-HGLPPR-G-PV--------LSC---------------- ----------------------------------------------------------EA ATQTELKPKL--------------AT------------VILRK----GL---RARALK-A RPRSLVDYKSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQV-------------------------------- -----------M-T-----PAQPST----------------------------------- ------------------------------------------------------------ ---SRTHTL--PFRRHPGLLHLESCGDLSTFT-TSE------------------------ ---------------------NQVAERKT------------------------------- ------------------------QR-L-EHERPHSLIGVV------------------- ----------------------RETVL >ENSGAGP00000001832 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MAGLSA ALQAAAPGPAAS------------------------------------------------ --------PAQPPP-------------------------------------------PPP PPLRRFQHYR-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------PPPAAFSPLSARR------------ ------------------------------------------------------------ ----------------------AAAAA--------------------GAQ---------- --------------------GLLPARPLLSLGLLQLILGCCM---------VALSFGALS LSGSPQVKNSCPFWAGSSVILSGIIGLTTWKRPV-------------------------- ------------VLLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGES KICFCCEEFHPAKCTEKENALKLYPVQSCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQVSVEEVEEQGRISDPEDFVPPVPPPSYFATFYSCTPRMNRRM LGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QISCEQGGAFQIPDVAEAVIGPPEPN------------------- ------------------------------------------------------------ ----------------------------DTQVSQAK-------QFGS------------- ------------------------------------------------------------ ------------------------SST--------------------------------- ------VPTVG------------------------------------------------- ---------------------------------------------GDIPDSFSRESLSPS NPSSAPAEQKPAC---K------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------RAFNP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRKRSKSDPV-L-HGLPPR-G-PV--------LSC---------------- ----------------------------------------------------------EA ATQTELKPKL--------------AT------------VILRK----GL---RARALR-A RPRSLVDYKSYIDTKLLVARFLEQSS--CSMTPDVHELVENIKSVLKSDEEHMEEAITSA SFL----------------------EQV-------------------------------- -----------M-T-----PAQPST----------------------------------- ------------------------------------------------------------ ---SRTHTL--PFRRHPGMLHLESCGDLSTFT-TSE------------------------ ---------------------NKVAERRT------------------------------- ------------------------QR-L-EHERPHSLIGVV------------------- ----------------------RETVL >ENSCPRP00005007844 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ILLVNLFILLSVVCVLLNLAGFILGCQGAQFVSSVPRCDL--VDLGES KICFCCEEFHPAKCTEKENALKLYPVQSCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQILSTRRSCID-ESQVSAEEGEEQHHSSDPEEFVPPVPPPSYFATFYSCTPRMNRRM LSSDVIPLPHIYGARMKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QISHEQEGAFQIPD------------------------------- ------------------------------------------------------------ ---------------------------------------------GSEAVAVP------- --------PE----------------LNDT--------------------------QTSQ VHEDIPSSSSRESLPPSDPRPEPKE----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------AC---K------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------RVFSP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRKRSKSDPV-L-HGLPPR-G-PV--------LSC---------------- ----------------------------------------------------------EA ATQTELKPEL--------------AT------------VILRK----SL---RARALR-A RPRSLIDYKSYIDTKLLVARFLEQSS--CSMTPDIHELVENIKSVLKSDEEHMEEVITSA NFL----------------------EQI-------------------------------- -----------M-T-----PVCPST----------------------------------- ------------------------------------------------------------ ---SRAHTL--PFRRHPGLLHLESCGDLSTFT-TAE------------------------ ---------------------NQVSERRS------------------------------- ------------------------QR-I-EQERPHSLIGVV------------------- ----------------------RETVL >ENSSMRP00000020650 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVA---- ------------------------------------------------------------ ------------------AGLAAVPEALRP----CSAAAAQNPSQPL----------PPP PP---------------------------------------------------------- --LRPRWSRA-------------------------------------------------- -----------------------------------------GLQQP-RPR---------- -------------------------------------PAVLSPLASRR------------ ------------------------------------------------------------ ----------------------AGASA--------------------------------- ---------------AAAGSALLPARPLLSLGLLQLILGCCL---------VALSFGALS LSGSPQVKNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVICVLLNLAGFILGCQGAQFVSSVPRCDL--VDVGES KLCFCCEEFMSAKCAEKENALKLYPVQSCSAVHLLLKKVLFSLCALNALTTTVCLVAAAL RYLQIFATRRSCIE-ETQVYVEEVEEQGRVSDPEDFVPPVPPPSYFATFYSCTPRMTRRM PGSDVIPLPHIYGARIKGVEVFCPLDPPPPYE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------TV------------------------------ -------------VNQTNHEQGGALPISDVAESV------NS------------------ ----------------------------------------------ST------------ ------------GQ-------------NDTQVPQD------------------------- -----GN----------------------------------------------------- ------------AL---------------------------------------------- ----------GSS----TSQTGLQPDPSSASEVTSK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------KALKP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LQKRSKSDPM-L-HAFLPK--GPV--------LSC---------------- ----------------------------------------------------------EA ATQTELKPEV--------------AT------------VILRK----SM---RAKAGR-A RPRSLIDYKSYIDTKLLVAKFLDQSS--CSMTPDIHELVEDIKSVLKSDEEHMEEVITSA SFL----------------------EQV-------------------------------- -----------M-A-----PAHPST----------------------------------- ------------------------------------------------------------ ---SRAHTL--PFRRHPGLLHLESCGDVSTFT-AAE------------------------ ---------------------ARLLERRT------------------------------- ------------------------QR-A-EHERPHSLIGVI------------------- ----------------------RETVL >ENSACAP00000001130 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------ILLVNLFVLLSVICVLLNLAGFILGCQGAQFVSSVPRCDL--VDVGEN KFCFCCEEFLPARCTEKENALRLYPVQSCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSGTE-EPQVCAEEVEEQAHISDPEDFVPPVPPPSYFATFYSCTPRMNRRM LDSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VSQ------------ ---------------------------MNLDQESTLQSSDVAEDFNGSSRQNNTHVSQDG DGLSSSAAETTLHPDPGMAPTGIHKGAP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------KP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------FRKRSKSDPV-L-HGFLSR--GPV--------LSC---------------- ----------------------------------------------------------EA ATQTEIKPEL--------------AA------------VILRK----SV---RAKALR-S RPRSLVDYKSYIDTKLLVAKFLEQAS--CSMAPDIHELVEDIKSVLKSDEEHMEEAITSA SFL----------------------EQV-------------------------------- -----------M-T-----PAHPST----------------------------------- ------------------------------------------------------------ ---SRAHTL--PFRRHPGLLHLESCGDVSTFT-TAE------------------------ ---------------------TRLLERRT------------------------------- ------------------------QR-S-ESERPHSLIGVV------------------- ----------------------RETVL >ENSCJPP00005008653 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPAVLPGSCCPVPGLSA G----------SPAAGTAMRPPGSL----------------------------------- --------PA----------------------------------------------EPSL PP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LRSRRAGC--------- ------------------------------------------------------------ ----------------------------P------------------------RPLPA-- --------ASFSSSRRASGAGLLPSRPLLSLGLLQLVLGCCM---------VALSFGALS LSGAQEVKNACPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFILLSVICVLLNLSGFILGCQGIQFVSSVPRCDL--VDVGEN KICFCCEEFHPTKCTEKAHALKLFPVKSCNAVHLLLKKVIFALCALNALSTTVCLIAAAL RYLQIFATRRSCMG-ECQISTEEIEEQGHISDPEDFVPPVPPPSYFATFYSFSPRMNRRM LGSGVIPLPHIYGARSKGIEVFCPLDPPPHYEAV-------------------------- ---------------------------------------------VN------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTGSEQESRLQ---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------EVGEEIVADSAES--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------RGRLASPGEEISNSSSRTSLLPSASAAPAEV------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------HRTFSP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LQKRSRSDPV-L-HCQLSQ--GAV--------VSC---------------- ----------------------------------------------------------EA ATQIEIKPQL--------------ST------------VTLRN----SL---RARALR-A RPRSLVDYKSYMDTKLLVARFLEQSS--CTMTPDIHELVENIKCVLKSDEEHMAEAITSA TFL----------------------EQV-------------------------------- -----------M-A-----PAQQDTA---------------------------------- ------------------------------------------------------------ ---LRAHVL--PFRRHPGLLHLESCGDLSTFT-AGE------------------------ ---------------------THLAERKT------------------------------- ------------------------QR-T-EHERPHSLIGVV------------------- ----------------------RETVL >ENSNMEP00000012683 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------MAAAARAGRGAARRGEAKPGRGGAGQRPPRRGGERRGRGRL RPRRHLPGGAGRAEPQEVGARVGWHRGGGRQARPSRRPPL-------------------- ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVPGLSA G----------SPAAGTATQSPASLPXXXXXXXXXXXXXXXXXXXXXXXXXARS------ -------SPA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------RRAPGAGLLPSRPLLSLGLLQLVLGCCM---------VALSFGALS LSGAPQVKNACPFWAGTSVILSGIIGLTTWKRPV-------------------------- ------------ILLVNLFVLLSVICVLLNLAGFVLGCQGAQFVSSVPRCDL--VDVGEN KICFCCEEFHPTKCTEKENALKLYPVKSCSAVHLLLKKVIFALCALNALTTTVCLIAAAL RYLQIFATRRSCID-ESQISTEEIEEQGHISDPEDFVPPVPPPSYFATFYSFTPRMSRRM LGSDVIPLPHIYGARIKGIEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VN------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QTGSEQESALQ---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------EADEEVVADSAEASGRQASQGEEIPKSSSRASLL LSAVSPM----------------------------------------------------- ------------------------------------------------------------ ----------PAEEVYK------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------RAFSP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LQKRSKSDPV-L-HCLLPQ--GPV--------LSC---------------- ----------------------------------------------------------EA ATQTEIKPQL--------------NT------------VMLRN----SL---RARALR-S RPRSLIDYKSYIDTKLLVARFLEQSS--CSMTPDIHDLVENIKCVLKSDEEHMAEAITSA TFL----------------------EQV-------------------------------- -----------M-A-----PAQQDMG---------------------------------- ------------------------------------------------------------ ---PRAHVL--PFRRHPGLLHLESCGDLSTFT-TGE------------------------ ---------------------D-LAERRA------------------------------- ------------------------QR-T-EHERPHSLIGVV------------------- ----------------------RETVL >ENSAPLP00000008303 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------M---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ILLVNLFVLLSVICVLLNLAGFILGCQGAQFVSSVPRCDL--VDMGEN KICFCCEEFHPTKCTEKENALKLYPVKSCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRSCID-ESQISAEEIEEQGHISDPEDFVPPVPPPSYFATFYSYTPRMSRRM LGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QISSEQEAALQ---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------IGVVEVVADSVETSGRQASQGDEIPKSSSRVSLS PSAASPA----------------------------------------------------- ------------------------------------------------------------ ----------PAEGAYK------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------RAFNP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LQRRSKSDPV-L-HCLLPQ--GPV--------LSC---------------- ----------------------------------------------------------EA ATQTEVKPQV--------------DA------------VTLRK----SL---RTRALR-S RPRSLIDYKSYIDTKMLVSRFLEQSS--CSMAPDIHELVENIKSVLKSDEEHMAEAITSA TFL----------------------EQV-------------------------------- -----------M-S-----PAPQAMS---------------------------------- ------------------------------------------------------------ ---LRAHEL--PFRQRPGLLHLESCGDLSTFT-AGEGQS--------------------- --------------------GQ-SAERRI------------------------------- ------------------------QR-A-EHERPHSLIGVV------------------- ----------------------RETVL >ENSDNVP00000005728 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------M---------VALSFGALS LSGSAQVKNACPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------ILLVNLFVLLSVICVLLNLAGFILGCQGAQFVSSVPRCDL--VDMGEN KICFCCEEFHPTKCTEKENALKLYPVKSCSAVHLLLKKVLFALCALNALTTTVCLVAAAL RYLQIFATRRTCAD-ESQVSTEETEEQGHVSDPEDFVPPVPPPSYFATFYSCTPRMTHRM LGSDVIPLPHIYGAGIKGVQVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QISCEQEDTLQ---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------MGVVEAATDSVDTSDRQASQDEEIPKSSSRVSLS PSNANPV----------------------------------------------------- ------------------------------------------------------------ ----------PAD---K------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------RAFNP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LQKRSKSDPV-L-HCLLPQ--GPV--------QSC---------------- ----------------------------------------------------------EA ATQTELKPEL--------------DT------------VTLRK----SL---RARALR-A RPRSLIDYKSYIDTKLLVARFLGQSS--CSMTPDIHDLVESIKSVLKSDEEHMAEAITSA TFL----------------------EQV-------------------------------- -----------M-A-----PAQQSMS---------------------------------- ------------------------------------------------------------ ---SRAHVL--PFRQHPGLLHLESCGDLSTFT-TAE------------------------ ---------------------SHLSERRI------------------------------- ------------------------QG-L-EHERPHSLIGVVAFGTNEKHSPFTNSTLSQM PLVFLQLFRPMKKPLVRPMNIF----- >ENSCPUP00000007153 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------MLLANLFVLLSIICVLLNLAGFILGCQGVQFVTSVPRCDL--VDTGEN KICFCCEELHLTKCTEEETALRLYHVKSCGAAHLLLKKVLFALCALNALTTTVCLVAAAL HYLQIFATRRSCID-ESQI-----EDQDHVLDPDDFVPPVPPPSYFATFYSCTPQTSCRM LGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------WS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QNSSEQEDALQ---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ISVVEVI-DSGEVSDRQASQGEEIPESSSRVSLS PSDASPV----------------------------------------------------- ------------------------------------------------------------ ----------PAEGV-------------------------------C------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RRAFSP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRKRSKSDPA-L-HSHLLQ--GAV--------LSC---------------- ----------------------------------------------------------EA ATQTEVSPQL--------------CA------------VTLRK----NG---RARALR-G RPRSLIDYKSYTDTRRLVAWILEQSS--CSMSPDVHELVESIKSVLKSDEKHMAEAITSA TFL----------------------EQV-------------------------------- -----------M-T-----PAQQATS---------------------------------- ------------------------------------------------------------ ---SRAPVL--PFRRRPGLLHRESCGDLSTFT-TDE------------------------ ---------------------DELPERRI------------------------------- ------------------------QR-A-EHERPHSLIGVV------------------- ----------------------RETVL >ENSFALP00000004965 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------LLLVNLFVLLSVISVMLNVTGLILGCQGIQFVSRVPRCDL--MDMDEN KTCLCCEELHPTKCTEAEAVLKLYHVKSCSAAHFLLKKVLLALSVLNALTATVCFIAAAL HYLQILASRRSCTG-EC-----EIEDEDRNLDPDDFVPPVPPPSYFAILNSCTPETSHSP PVPDVISLPYIYVTRINGVEVFCPLDPPPPYETV-------------------------- ---------------------------------------------CS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------LKSSEQGGALQM--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----NG------------------------------------------------------ -MEDV-----------------------------DSGEVSDRQSSQAEEIQEPSSRMSFS PANASCVP-AGV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SRRAFHP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LRKYSKSDPVLL-HCQLPQ--ETV--------LGC---------------- ----------------------------------------------------------ET AAPSDVSP-Q--------------NV------------VTLRR----SS---RARAVR-G RPQSLIDYKSYMDTKRRVAWILEQSS--CSMSPDIHDLVENIKSVLKSDEKHMAEVVSSA TFL----------------------EQV-------------------------------- -----------M-T-----PSQQATS---------------------------------- ------------------------------------------------------------ ---LRGRVS--PFRLHPGLLYLQSCGDLSTFT-TEG------------------------ ---------------------EQLAERRI------------------------------- ------------------------QR-A-EHERPHSVVGVV------------------- ----------------------RETVL >ENSCCEP00000009532 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------M-------------------------- ------------MLLVNLFVLLSMISVMLNVVGLILGCEGIQFVSGVPRCDL----MDEN KICLCCEEPHPTACTEEEAVLKLYHVKSCDAAHLLLKKVLLALSALNALAATVCFIASAL HYLQILASRRFCTG-ES-----EVEDEDYDLDPDDFVPPVPPPSYFATFNSCTPQTSHST AVSRVISLPHIYGMRIRGAEVFCRLDPPPPYEAV-------------------------- ---------------------------------------------GS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------FRSSEQGSAPQL--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----ND------------------------------------------------------ -MEDV-----------------------------DSGEVSDRQTSQAEEIQEPSSRVSLS PSNASCVS-TGV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------NRRAFNS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LWKYSKSDPV-L-HCQLPQ--GTV--------LNC---------------- ----------------------------------------------------------ET AALNDVNP-L--------------NA------------VTLQK----SS---RARALR-G RPQSLIDYKSFMETKQRVARILEQSS--SSMSPDVHDMVENIKSVLKSDEKHMAEAVTSA TFL----------------------EQV-------------------------------- -----------M-T-----HAQQATP---------------------------------- ------------------------------------------------------------ ---LRVSAL--PLRLHPGLLYLESCGDLSTFT-TEG------------------------ ---------------------EHPAERRI------------------------------- ------------------------KR-A-EHERPHSLIGVV------------------- ----------------------RETVL >ENSPMJP00000011851 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------VLPGSCCPLQGL-- ------------------------------------------------------------ -----------------------V-----------------------------------L PP---------------------------------------------------------- ------------------------------------------------------------ -----------------------------RAAAGSLSTTGDGLSPP-------------- -----PLRAGAAPR--------------------------------RR------------ ------------------------------------------------------------ ----------------------------P--------CPP-------------------- ----------------------LPFHSLLGLGLLQTGLGCAL---------VALSFGVLS LSSAPQVKNS--LWAGSSTILCGILGLTTWKRPM-------------------------- ------------MLLVNLFVLLSMISVMLNVIGLIIGCEGIQFVSGVPGCDL----MDEN KTCLCCEEPHPTACTEAEAVLKLYHVKSCGAAHLLLKKVLLALSALNALAATVCFIASAL HYLQIFASRRFCTG-EP-----EVEDEDYDLDPDDFVPPVPPPSYFATFNSCAPQTSQST AVSHVISLPHIYGMRIKGVEVFCRLDPPPPYEAV-------------------------- ---------------------------------------------GS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------LKSSEQGGAPEL--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----NG------------------------------------------------------ -MEDV-----------------------------DSEEVSDSQTSQAEEIQEPSSRVSLS LSNASSVS-AGV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------NRRAFNS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LWKYSKSDPA-L-HCQLPQ--GTV--------LNC---------------- ----------------------------------------------------------ET AALNDVNP-L--------------NA------------VTLQK----SS---RARALR-G RPQFLIDYKSFMETKQCVARILEQSS--SSMSPDIHDVVENIKSVLKSDEKHMAEAVTSA TFL----------------------EQV-------------------------------- -----------M-T-----HAQEATP---------------------------------- ------------------------------------------------------------ ---LRVSVL--PLRLHPGLLYLESCGDLSTFT-TEG------------------------ ---------------------EHPAERRI------------------------------- ------------------------KR-A-EHERSHSLIGVV------------------- ----------------------RETVL >ENSZALP00000013206 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MGSFEKAECHSQLQLVNGICSVIGSLS WVSVPTADNFVLVFQVNLFVLLSMISFMLNGIGLILGCQGIHFVSGLPRCHL--MDMDEN KTCFCCEERHATTCTEAKAVLKLYHVKSCSAARLVLKKVLLVVSALNALTATVCFAAAAL HYWLTLASRGSCTD-EC-----EIEGEDHNLDPDDFVPPVPPPSYFATFNSCTPQ-SHST PVSDVISLHCISVTRIRGVEVYCPLDPPPPYETV-------------------------- ---------------------------------------------CS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------VKSSEQGGALQI--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----NG------------------------------------------------------ -VEEV-----------------------------DSGEVSERQSSQAEEIQEPSSRVSLS PSNAGCVP-AGR------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------NRRAFDP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------LWKCSKSDRGLL-HCQLPQ--GTV--------LSC---------------- ----------------------------------------------------------ET ATLNDVNP-L--------------NA------------VTLRK----SS---GARASR-G RPQSLIDYNSYMDTKRRVAWILEQ-S--CSMSPDIRDLVENTKSVLKSDEKHMAEAVTSA SFL----------------------EQV-------------------------------- -----------MTT-----PAQQATS---------------------------------- ------------------------------------------------------------ ---LRVHVL--PSGLHSRLLYLESCGDLSTFT-TEG------------------------ ---------------------EQLAERRI------------------------------- ------------------------QR-A-EHERPRSVIGVV------------------- ----------------------RETVL >ENSLACP00000011671 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGLSA LPQSSDPA---------------------------------------------------- ---------------------------LRSR-SRC----------------------PPL PA--------------------------------------------------------AR S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------P-------MCPP-------------------- --------------RAAP--ALLPGRPLLSLGLLQLVLGCSM---------VALSFGALS LSGSPQIRNSCPFWAGSSVILSGIIGLTTWRRPM-------------------------- ------------LLLVNLFVLLSVVCVLLNLAGFVLCCQGAQLVSSVPSCQM--VELAEG DACLCCDEFQASKCAENENVLKLYPVQSCSAVRLLLKKVLFALCALNALTTTVCLVAAAL RYLQMFAARRPCLD-ETRATAEDGGGPAPVPDPEEFVPPIPPPSYFSTFYSYTPRMNRRM LGTDVIPLPHIYGARIKSVEVFCPMEPPPPYEAV-------------------------- ---------------------------------------------VG------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QSNTEQE-------------------------------------- -----------------------------------------------TENFQVWQCPISR ASPTSSVCIYVTG----------------------------------------------- -----G------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PCRESPSSNLGSCTSHPNSRVTSTSGCRKPC- ------------------------------------------------------------ ---KHVLQ----RSHSDPL-L-QDLASR-VRLV--------LSC---------------- ----------------------------------------------------------EA ATQTETRPDV--------------AQ------------VTLRR----CI---RARVAR-A RPRSLVDYQSYQDTKLLVARFLEQSS--CSMTPDVQELVENIKSVLKSGEEHMDEAVLSA NFL----------------------EQV-------------------------------- -----------M-N-----NARQATA---------------------------------- ------------------------------------------------------------ ---GRVHTL--PLRRRPGLLHLESCGDLSTFT-TVE------------------------ ---------------------CQLEERRG------------------------------- ------------------------QR-A-EQDRPHSLIGVV------------------- ----------------------RETVL >ENSXETP00000037914 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVLLPGSCCPMAGLS- -----------------------------------------------------TSMGNVP TASSPGGDPA-------------------------------------------------- -------------------------------------------------------LH--- ---RPRRSRG-------------------------------------------------- -----------------------------------------GLQPP---RCS-------- ---------------ASQGLCSPP-----------PPPA----LSSRR------------ ------------------------------------------------------------ ---------------------------------------------RAGSGL--------- ---------------------ILPGRPLLSLGLLQLILGCCT---------VALSFGALS LSKSPQIRSSCPFWAGSSVILSGIVGLTTWKRPM-------------------------- ------------VLLVNLFVMLSVVCVLLNLAGFILGCQGAQFVSSVPSCQL--VEMNEG KVCVCCEEIYANKCLERENFLKLFPVQSCNAVHLLLKKVFFALCALNALTTTVCLVAAAL RYLQLLTTRRPCTD-ESQISAEEGEEQERVPDPDDFVAPAPPPSYFSTFYSCTPRINQRM IGNETIPLPHIYGSRFKGIEVFCPMEPPPPYEAV-------------------------- ---------------------------------------------VS------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------QSSSSEETAVQIPDTA----------------------------- ------------------------------------------------------------ -----------------------------------AVSTSSELH---------------- -----G--AQVNPEPSSTSNVDVEPVL--------------------------------- ------------------------------------------------------------ ----------G------------------------------------------------- -------ASAQTDEAMESDLPNMP------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SRKRSHSDPV-I-SDLPTK--GVA--------PSC---------------- ----------------------------------------------------------EA ATQTEVRPPL--------------EA------------VTLRR----AL---RARAVR-S RPRSLVDYKSYIDTKLLVARFLEEPS--CSMTPDIRELVESIKTVLKSDEEHMDEAILSA NFL----------------------DEV-------------------------------- -----------M-I-----PNQQVTT---------------------------------- ------------------------------------------------------------ ---NTAPRL--QHRQYPGLMHLASCGDVSTFC-AAE------------------------ ---------------------TQREARRS------------------------------- ------------------------HG-R-ASERPHSLIGVV------------------- ----------------------RETIL >ENSMALP00000010961 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MLHGLF CSSPVLALVSLLAQYVKANLRPNLGLSQNVILNWTPPWHCYRTLPVNSAGIHPFIRENNT SLVQIDLQTFCFRAACRSSDVAPSCAAGVLLSGYR------------------------- ------------------------------------------------------------ ----VFPAPRAILQKQTPWLARFFC----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GVSRL--------- ---------------------LLPGRPLLSLGLLQLLLGGSM---------VALSFGALS LSNSALIRNSCPFWAGSSVILSGIVGLTTWRRPM-------------------------- ------------LLLVNVFVLLSVVCVLLNLAGFILCCQGAQLVSSMTSCKL--SEDGH- -ICYCCSLSPSSKCTE-EKLLELHPAHNCSTMRILLKKVLFALCALNALTTAVCLMAAAL RYLQIFTSRTPCMD-EPRATAEEREEPAQVPDPDEFVAPAPPPSYFSTFCSYTPRLARRM LGDSVIPLPHIYGARIKGVEVFCPLEPPPPYEAV-------------------------- ---------------------------------------------AGSSNNAVIEETESA LTALTVNSTTT------------------------------------------------- ------------------------------------------------------------ --------PPGASV-Q-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------GVIPQANPQLWPP ---------------------P--------QQ----------------QQHI-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PAL------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S FWKKARIC----RSNSDPV-L-MDLAAK----V--------WSS---------------- ----------------------------------------------SDTPLTPSPQTTDS STQT--------SQPTLTANT--QGQ------------VTLRQGNNISR---TPR--R-P RPSSMVDYQSYRHTQQLVRKILEQPAS-QGLAPEVQELVDSIRNVLQSDQEHMKEAVRCA SYI----------------------EQV-------------------------------- -----------F-TDAEMGPSQPKHS-----QQWQP-AGS-------------------- ------------------------------------------------------------ ----SSQTLSWPLRRRSGLLHLQSCGDLSSFT-FAALESLEYRGNRK------------- ---------------------------------------------------VV------- ------------SRTGSRLASRTGSP-LGHPGRPHSLIGVF------------------- ----------------------KETVI >ENSSDUP00000009332 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVTGAS- --QLAEPS---------------------------------------------------- ---------------------------YRNR-PRG------------------------- -----------------------------------LS---------------AS----SR F----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------A----------------GGGSRL--------- ---------------------LLPGRPLLSLGLLQLLLGGSM---------VALSFGALS LSSSPAIRNSCPFWAGSSVILSGIVGLTTWRRPM-------------------------- ------------LLLVNVFVLLSVVCVLLNLAGFILCCQGAQLVSSMTSCQL--SEDGD- -VCYCCSLSPSSTCPE-EKLLELHPAHSCGTMRILLKKVLFALCALNALTTAVCLMAAAL RYLQIFSTRAPCMD-EPRATVEEREEPPQVPDPDEFVAPAPPPSYFSTFYSCTPRLTCRT LGDSVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------AGSSTNTDTQETEIP LTELPVNTTTT------------------------------------------------- ------------------------------------------------------------ --------PP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------P--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------P------------------------------------------- ----------TCGADLSLQTVSVSPGVVDQAKSQLQPLPPSLPLQ-------QPHAPGPT PWRRAGIR----HSSSDPV-L-MDLAAK----G--------WSS---------------- ----------------------------------------------SDTPLAPSPQTTDS STQT--------SQPTLAAHA--QGQ------------VTLRRGNNDSR---TPR--R-P RPSSMVDYQSYRHTQHLVRRILEQPAA-QGLAPEVQELVDSIRNVLQSDEEHMEEAVRCA SYI----------------------EQV-------------------------------- -----------F-TDSEMGPSQPPQQQQQQQQQQQP-AAS-------------------- ------------------------------------------------------------ ----SSQTFPRPPRRRCGVLHLRSCGDLSSFT-CA--ESPERQGNNREVVSG-------- -----------------------------------------------AGSRVG------- ------------SRAGSRTGSRTGSR-LDRPDRPHSLIGVF------------------- ----------------------RETVL >ENSSLDP00000014954 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVTGAS- --QLAEPS---------------------------------------------------- ---------------------------YRNR-PRG------------------------- -----------------------------------LS---------------AS----SR F----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------A----------------GGGSRL--------- ---------------------LLPGRPLLSLGLLQLLLGGSM---------VALSFGALS LSSSPAIRNSCPFWAGSSVILSGIVGLTTWRRPM-------------------------- ------------LLLVNVFVLLSVVCVLLNLAGFILCCQGAQLVSSMTSCQL--SEDGD- -VCYCCSLSPSSTCPE-EKLLELHPAHSCGTMRILLKKVLFALCALNALTTAVCLMAAAL RYLQIFSTRAPCMD-EPRATVEEREEPPQVPDPDEFVAPAPPPSYFSTFYSCTPRLTCRT LGDSVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------AGSSTNTDTQETEIH LTELTVNTTTT------------------------------------------------- ------------------------------------------------------------ --------PP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------P--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------P------------------------------------------- ----------TCDADLSPQTVSVSPGVVDQAKSQLQPLPPPLPLQ-------QLHAPGPT PWRRAGIR----HSSSDPV-L-MDLATK----G--------WSS---------------- ----------------------------------------------SETPLAPSPQTTDS STQT--------SQPTLAAHA--QGQ------------VTLRRGNNDSR---TPR--R-P RPSSMVDYQSYRHTQHLVRRILEQPAA-QGLAPEVQELVDSIRNVLQSDEEHMEEAVRCA SYI----------------------EQV-------------------------------- -----------F-TDSEMGPSQPKLPQQQQQQQQQP-AAS-------------------- ------------------------------------------------------------ ----SSQTFPRPPRRRCGVLHLRSCGDLSSFT-CA--ESPERQGNNREVVSG-------- -----------------------------------------------AGSRVG------- ------------SRA----GSRTGSR-LDRPDRPHSLIGVF------------------- ----------------------RETVL >ENSLCAP00010051335 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVTGAS- --QLAEPS---------------------------------------------------- ---------------------------YRNR-PRG------------------------- -----------------------------------FS---------------AS----SR I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------A----------------SGGSRL--------- ---------------------LLPGRPLLSLGLLQLLLGGSM---------VALSFGALS LSNSPPIRNSCPFWAGSSVILSGIVGLTTWRRPM-------------------------- ------------LLLVNVFVLLSVVCVLLNLAGFILCCQGAQLVSSMTSCQL--SEDGD- -VCYCCSLSPTSKCPE-EKLLELHPAHSCSTMRILLKKVLFALCALNALTTAVCLMAATL RYLQIFTARTPCMD-EPRATVEEREEPAQVPDPDEFVAPAPPPSYFSTFYSYTPRLARRM LGGSVIPLPHIYGARMKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------AGSSTNAVTQETEIA LTELTMNSTTT------------------------------------------------- ------------------------------------------------------------ --------PP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PT-------------------------------------- ----------------------------------------------C----VRDTSP--- ----------------------------------------QMVSVTPGVVPKARPQTQP- ---------------------P--------QQ----------------QQHP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PGLIH---------------------------- ---------------Q-------------------------------------------- ------------------------------------------------------------ --RKAGIR----RSNSDPV-L-MDLAAK----V--------WSS---------------- ----------------------------------------------SDTPLTPSLQTTDS STQT--------SQSTLAANT--QGQ------------VTLRHGNLDSR---TPR--R-P RPSSMVDYQSYQHTQQLVRKILEQPAA-QGLAPEVQELVDSIRNVLQSDQEHMEEAVRCA SYI----------------------EQV-------------------------------- -----------F-TDSEMDPSQPKPP--QQQQQQQP-AGS-------------------- ------------------------------------------------------------ ----SSQTFPRPPRRRPGLLHLQSCGDLSSFS-CAALESVDQQGNGRKLV---------- -------------------------------------------------SRAG------- ------------SRAGSRAGSRTRSR-LDHPDRPHSLIGVF------------------- ----------------------RETVL >ENSCGOP00000017463 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVIGAS- --QLAEPP---------------------------------------------------- ---------------------------YRNR-PRG------------------------- -----------------------------------LS---------------AS----SR I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------A----------------GGGSRL--------- ---------------------LLPGRPLLSLGLLQLLLGGSM---------VALCFGALS LSNSPPIRNSCPFWAGSSVILSGIVGLTTWRRPM-------------------------- ------------LLLVNVFVLLSVVCVLLNLAGFILCCQGAQLVSSMTSCQL--SEAGD- -VCYCCSLSPSSKCPE-EKLLELHPAHSCSTMRILLKKVLFALCALNALTTAVCLMAAAL RYLQIFTARTPCMD-EHRATAEEREEPAQVPDPDEFVAPAPPPSYFSTFYSYTPRLARRI LGDSVIPLPHIYGARIKGVEVFCPLDPPPPYEVV-------------------------- ---------------------------------------------AGSSANAVTQETEIA LTELTMD----------------------------------------------------- ------------------------------------------------------------ ---------P-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------P--------------------------------------- ------------------------------------------------------ASPPGA SVPVSD-------------------------------RSSQMVSASPGILPQAKPQLQPQ ---------------LQPQLQP--------QQ----------------QQQPHLQPQQQQ QQPHLQQQQQPHLQQ----HQPQQQQP--------------------------------- ---------------------------HLQQQLQAQQQQPQLQPQQQQPQLQQQQQQQQQ QLQQQQQQPQLQQQQQQPQLQQQQQQPQLQQQQQQPQLKQQQQPQQQQPQLQQQQQQQQQ QQQQQPQLQQQQPQLQQQQQQQQPQLQQQQQQPQLKQQQQQPQQQQPQLQQQQQQQQPQL QQQQQQPQLQQQS-------------SPAL------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S PWRKERIH----RSNSDPV-L-MDLVSK----A--------LSS---------------- ----------------------------------------------SDAPLPASPQTTDS STQT--------SQPTLTVYS--QGQ------------VTLRRGNNDSR---TPR--Q-P RPSSMVDYQSYRHTQQLVRKILEQPAA-QGLTPEVQELVDSIRTVLQSDQEHMEEAVRCA SYI----------------------EQV-------------------------------- -----------F-TDSEMGPSQPKPP-------QQP-AGS-------------------- ------------------------------------------------------------ ----HSQTYPRPPRRRPGLLHLQSCGDLSSFT-CAALESVEHRGSSRKV----------- ------------------------------------------------------------ ---------------GSRAGSRTGSR-LDHPERPHSLIGVF------------------- ----------------------RETVL >ENSMAMP00000027521 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVTGTS- --QLAEPS---------------------------------------------------- ---------------------------YRNR-PRG------------------------- -----------------------------------FS---------------AS----SR I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------A----------------GGVSRQ--------- ---------------------LLPGRPLLSLGLLQLLLGSSM---------VALSFGALS LSNSPPIRNSCPFWAGSSVILSGIIGLTTWRKPM-------------------------- ------------LLLVNVFVLLSVVCVLLNLAGFILCCQGAQLVSSMTSCQL--SEDGD- -VCYCCALSASSKCNK-EKLLELHPAHSCSTMRILLKKVLFALCALNALTTAVCLMAAAL RYLQIFTTRTPCMD-EPRATVEEQEEPAQVPDPDEFVAPAPPPSYFSTFYLNTPRLACRT LEETVIPLPHIYGARIKGVEVFCPIEPPPPYEAV-------------------------- ---------------------------------------------AESSNNVVTEETGIA LTNLTMNPTTT------------------------------------------------- ------------------------------------------------------------ --------PPRISV-Q--------------------------DMSSGMVSVALDITPQAK ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------LP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P--------QQ----------------QKHT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PTL------------------------------ ------------------------------------------------------------ -----------------------------------------------------------N PWRKSGIH----RSKSDPL-L-MDLTAK----V--------WSS---------------- ----------------------------------------------TDTHLVPSPKTTDS STQT--------SQTILAAHT--QRQ------------VTLRRGNN-SR---LPW--H-P RPSSMVDYQSYQHTQQLVRKILEQPAA-QGLAPEVQELVDSIRQVLQSDQEHIEEAVRCA CYI----------------------EQV-------------------------------- -----------V-TDSEMTSNQPRSP------QQQP-SGS-------------------- ------------------------------------------------------------ ----SFQTFPQAPRRMPGLLHLQSCGDLSSFTSCAALESSEHGGKSRNMELT-------- ------------------------------------------------------------ --------------AGSRSSSRAGSH-LNHPDRPHSLIGVF------------------- ----------------------RETIL >ENSATEP00000015501 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------MC---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------FCTVLLYINIIFLSFSLCFQ----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------VILSGIVGLTTWRRPM-------------------------- ------------LLLVNVFVLLSVVCVLLNLAGFILCCQGAQLVSSMTSCQL--SEDRD- -VCYCCPVAPTSQCPK-EKLLELHPAYSCSTMRVLLKKVLFALCALNALTTAVCLMAAAL RYLQIFTARTPCMD-EARATLEEREEPAQVPDPDEFVAPAPPPSYFSTFYSYTPRLARRM LGDSVIPLPHIYGARIKGVEVFCPLDPPPPYEAI-------------------------- ---------------------------------------------AESSTHAVPQEAEIA MTELTVNPASTTPDTSPHMV---------------------------------------- ---------------------------------------------------PIVSPGKPQ L-----QLPP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------P--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------PL-----QQQQ----------------QQHT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PTQ------------------------------ ------------------------------------------------------------ -----------------------------------------------------------N RSKKAGIR----RSNSDPV-L-MDLAAK----V--------WSS---------------- ----------------------------------------------CDSPLAPPPQTTDS STQT--------SQPTLAAHT--QAQ------------VTLRRSKNNSR---TPR--R-P RPSSMVDYQSYRHTQQLVRKILEQPAA-QGLTPEVQELVDSIRNVLQSDQEHMEEAVRCA SFI----------------------EQV-------------------------------- -----------F-TESEMSSSQPKNP------QQQHLAAS-------------------- ------------------------------------------------------------ ----CSHTFPRPPRRRPGLLHLKSCGDLSSFT-CAALESVEHGGNRRK------------ ------------------------------------------------------------ ------------------AVSRAGSR-LDHPDRPHSLIGVF------------------- ----------------------RETVL >ENSSPAP00000023214 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPFTGVS- --QLTESS---------------------------------------------------- ---------------------------NRNR-VRG------------------------- -----------------------------------LS---------------GS----SR I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------S----------------GRGSGL--------- ---------------------LLPGRPLLSLGLLQLLLGGSM---------VALSFGALS LSSSPPIRNSSPFWAGSSVILSGIVGLTTWRRPM-------------------------- ------------LLLVNVFILLSVVCVFLNLAGFIMCCQGAQLVSSTTSCQL--SEAGD- -VCYCCSLSPTSKCPE-DKLLELYPAHSCNTMRILLKKVLFALCALSALTTAVCLMAAAL RYLQIFTARTPSMD-DPRATVENMEEPPQAPDPDEFVAPAPPPSYFSTFCSYTPRLSRRM LGNSVIPLLHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------VGSSANAVTQEAE-- ------------------------------------------------------------ ------------------------------------------------------------ LTTNQAAAPPGASV-Q--------------------------DMS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------P--------------------------------------- ------------------------------------------------------------ ----------------------------------------QMESPTPNVVPKAKTHLHPP PPP-------------PPPPPP---------------------------QNT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PAL------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T SCRKKRIC----RSNSDPV-L-NDFTAK----V--------WIS---------------- ----------------------------------------------SDAPLAHSPQTADS STQT--------SQPMLAAHT----Q------------VTLRRGKNNSR---TPR--R-P RPTSMVDYQSYQHTQHLVRKILEQPAV-QGLAPEVQELVDSIRNVLQSDQEHMEEAVRCA SYI----------------------EQV-------------------------------- -----------F-TDSVSGPTQPKPP-------RQP-RGP-------------------- ------------------------------------------------------------ ----SPQTFPRLPNRWPSLLHLQSCGDLSSFS-CAALESLEHQGNSKT------------ ---------------------------------------------------AR------- ------------LRAGCRAGTRGRSR-LDHPERAHSLTGVF------------------- ----------------------KETVL >ENSAOCP00000000246 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPITGAS- --QLAESS---------------------------------------------------- ---------------------------NRNR-PRG------------------------- -----------------------------------LS---------------GS----SR I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------G----------------GGGSRL--------- ---------------------LLPGRPLLSLGLLQLLLGGSM---------VALSFGALS LSSSPPVRNSSPFWAGSSVILSGIVGLTTWRRPM-------------------------- ------------LLLVNVFILLSVVCVFLNLAGFIMCCQGAQLISSTTSCQL--SEAGD- -VCYCCSLSPTSKCPE-DKLLELYPAHSCNTMRILLKKVLFALCALSALTTAVCLMAAAL RYLQIFTTRTPYMD-EPRATVENVEEPPQSPDPDEFVAPAPPPSYFSTFCSYTPHLSRRM LGNSVIPLLHIYGARIKGVEVFCPLDPPPPYAAV-------------------------- ---------------------------------------------VGSSANAATQETE-- ------------------------------------------------------------ ------------------------------------------------------------ LILNQAATPPGASV-QV------------------------LDLS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------P--------------------------------------- ------------------------------------------------------------ ----------------------------------------QMVSASPNVVPKAKPQLHPP PSPSSLPPP------LPPQPPP--------QQ----------------QQNM-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PAL------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T SCRKERIC----RSNSDPV-L-SDLTAK----V--------WIS---------------- ----------------------------------------------SDAPLAHPPQTADS STQT--------SQPMLAAHT----Q------------VTLRKGKNSSR---TTRQPR-P RPTSMVDYQSYQHTQHLVRRILEQPAV-QGLAPEVQELVDSIRNVLQSDQEHMEEAVRCA SYI----------------------EQV-------------------------------- -----------F-TDSNTGPTQPKPP-------QQP-RGT-------------------- ------------------------------------------------------------ ----SPQTFSHLPEKWSCLLHLQSCGDLSSFS-CAAVKSLEQQGKSAT------------ ---------------------------------------------------AG------- ------------LRGSARADSRGRSR-MDHSERAHSLTGVF------------------- ----------------------RETVL >ENSAPEP00000018422 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPITGAS- --QLAESS---------------------------------------------------- ---------------------------NRNR-PRG------------------------- -----------------------------------LS---------------GS----SR I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------G----------------GGGSRL--------- ---------------------LLPGRPLLSLGLLQLLLGGSM---------VALSFGALS LSSSPPIRNSSPFWAGSSVILSGIVGLTTWRRPM-------------------------- ------------LLLVNVFILLSVVCVFLNLAGFIMCCQGAQLISSTTSCQL--SEAGD- -VCYCCSLSPTSKCPE-DKLLELYPAHSCNTMRILLKKVLFALCALSALTTAVCLMAAAL RYLQIFTARTPYMD-EPRATVENVEEPPQSPDPDEFVAPAPPPSYFSTFCSYTPHLSRRM LGNSVIPLLHIYGARIKGVEVFCPLDPPPPYAAV-------------------------- ---------------------------------------------VGSSANAATQETE-- ------------------------------------------------------------ ------------------------------------------------------------ LIENQAATPPAASV-QV------------------------LDMS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------P--------------------------------------- ------------------------------------------------------------ ----------------------------------------QMVSASPNVVPKAKPQLHPP PSPSSPPPP------LPPPPPP--------QQ----------------QQNM-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SAL------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T SCRKERIC----RSNSDPV-L-SDLTAK----V--------WIS---------------- ----------------------------------------------SDAPLAHPPQTADS STQT--------SQPMLAAHT----Q------------VTLRKGKNSSR---TTRQPR-P RPTSMVDYQSYQHTQHLVRRILEQPAV-QGLAPEVQELVDSIRNVLQSDQEHMEEAVRCA SYI----------------------EQV-------------------------------- -----------F-TDSNTGPTQPKPP-------QQP-RGT-------------------- ------------------------------------------------------------ ----SPQTFPHLPEKWSCLLHLQSCGDLSSFS-CAAVKSLEQQGKSET------------ ---------------------------------------------------AG------- ------------LRGSARADSRGRSC-LDHSERAHSLTGIF------------------- ----------------------RETVL >ENSLBEP00000012719 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVT---- ----AEPC---------------------------------------------------- ---------------------------FRNR-PRG------------------------- -----------------------------------LS---------------AS----SR L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------S----------------GGGSRL--------- ---------------------LLPGRPLLSLGLLQLLLGGSM---------VALSVGALS LSGSPPVRTACPFWAGSSVILSGVVGLTTWRRPM-------------------------- ------------LLLVNVFVLLSVVCVLLNLAGFILCCQGAQLVSSLTSCQL--SEARD- -VCYCCSVSSTSECPQ-EKLLELHPAHSCSTMRILLKKVLFALCALNALTTAVCLMAAAL RYLQIFSSRTPCMD-EPRATVEDREQAAQVPDPDEFVAPPPPPSYFSTFYSYTPRLARRM LGDSVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------AGSSTHTETQECQI- ------------------SVSEET------------------------------------ -------------------------------------------------MTPL------- --------PPGASV-Q-------------------------------------------E SPPR-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- -------------------LP--------------------------------------- --------------------------------------------------------PPAN ----------------------------------------------------------PP LQPSPPPPP------PPTPPPP--------QQCTPPPQLRNPSPRTPPQQHS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PAL------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I PRRKTRIH----RSSSDPV-L-MDLAAK----VQSSGAHLN------------------- -----------------------------------------------------PPQTTDS STQT--------SQPLLAPPT--QAQ------------VTLRRANRESR---SAR--Q-P RPSSMVDYQSYRHTQQLVRRILEQPAA-QGLTTEVQELVDSIRSVLQTDQEHMEEAVRCA SYI----------------------EQV-------------------------------- -----------F-SDSQVRPHHSDPP--QQQE-------V-------------------- ------------------------------------------------------------ ----GSQTFPRPPRRTPGLLHLQSCGDLSSFT-CAAIDSVEHRGNRR------------- ---------------------------------------------------VR------- ------------SRAGSRAGSRTGSR-PDHPERPHSLIGVF------------------- ----------------------RETVL >ENSELUP00000005166 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVTGVSL ASQLADPS---------------------------------------------------- ---------------------------FRSRPPRC------------------------- -----------------------------------IS----------------T----SR M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------P----------------GSQSRLL----P--- --------------------ALLPGRPLLSLGLLQLVLGCSM---------VALSFGALS LSSSPPIRNSCPFWAGSSVILSGIVGLTTWRRPM-------------------------- ------------LLLVNLFVLLSVVCVLLNLAGFILCCQGAQLVSTMTSCQL--SKAGD- -VCNCCPQTPTVNCPE-EKLLKLFPGHSCSTMKVLLKKVLFALCALNALTTAVCLVAAAL RYLQIFSTRRPCLD-EPRPIAEEVEEPAVIPDPDEFVPPAPPPSYFSTFYSYTPRLARRM FGDSVIPLPHIYGARFKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------TG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------GSTVAEATQNTEI------------------------------------- ------------------QIP--------------------------------------- ------------------------------------------------------------ ---MTDLTDLAEELTDISEAGTSLRDV--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SAQTAVVPLSSSPLST PMHQARSPEDTAVPLIRSQRRQRIRRSSSDPVLLDLDVKVLNGQAAT--------QTIEA STQT--------SQSALAAQSAQLQT------------VTLRRG---GR---GPR--R-P RPFSMVDYQSYRHTQQLVSRFLEQPAH-SSLTPEVQELVDSIRSVLRSDQEHMEEAVRCA SYI----------------------EQV-------------------------------- -----------I-TVS-------------------------------------------- ---------------------------------------AASPPDSAIPQSLPRLRPNSP LSNYSSQTLPQPLRKRPGLLHLRSCGDLSTFT-WAEQQPL-------------------- ------------------------EARQRGGSRSR--------------SRTG------- ------------SRVGSRSSSRAGSR-LDHQERPHSLIGVC------------------- ----------------------RETVL >ENSHHUP00000015114 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SIPVVLPGSCYPVTRVSL GSQLAGSS---------------------------------------------------- ---------------------------FRSRPPRC------------------------- -----------------------------------IS----------------S----SR M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------P----------------GSQSQLL----P--- --------------------ALIPGRPLLSLGLLQLVLGCSM---------IALSFSALS LSSSPPIRNSCPFWVGSSVILSGIVGLTTWRRPM-------------------------- ------------LLLVNMFVLSSVVCVLLNLAGFILCCQGAQLVSTITNCQL--SEVGD- -VCNCCPQTPTAKCPE-EKLLKLYPGHSCSTMRVLLKKVLFALCALNALTTAVCLVAAAL RYLQVFTTRRPCMD-YPRPIAEEVEEPTIIPDPDEFVPPAPPPSYFSTFYSYTPRLARRM FGDSVIPLPHIYGARIKGLEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------TG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------GSALATATQETEI------------------------------------- ------------------QIP--------------------------------------- ------------------------------------------------------------ ---VTDLTELAEELSNSSEAGTSIRDVGPQTTVVAVPTS-------------------PP SYPSPPSPPRLQVRLPQGAPVP-------------------------------------- -------------------------------------------------------PV--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RRSQ- ------------------------------------------------------------ ---RQRIM----RSYSDPV-L-LDLAAK----V--------LSC---------------- ----------------------------------------------------------EA ATQT--------SQSALAAQSSRTQT------------VTLRQA---GR---GPR--R-P RPSSMVDYQSYRHTQQLVSRFLEQPAH-CHLTPEVQELVDSIRSVLRSDQKHMEEAVRCA SYI----------------------EQV-------------------------------- -----------I-TVSER------------------------------------------ AAIPQSLSLPRPRSRPSAALLD----------------C--------------------- ----SSQTLPQPLRKRPGLLHLGSCGDLSTFT-WAEQQPL-------------------- ------------------------EARQGGGSGSRSWS--------RAGSRVG------- ------------SRVGSRSTSRVGSR-LDHHERPHSLIRVF------------------- ----------------------RETVL >ENSDCDP00000034676 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCRVSGASL AAPPADAS---------------------------------------------------- ---------------------------HRSR-GRG------------------------- -----------------------------------LPAAG------------------GR M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------P----------------GPQSRLI----P--- --------------------ALLPGRPLLSLGLLQLVLGCSM---------VALSFGALS LSNSAPIRNSCPFWAGSSVILSGIIGLTTWRRPM-------------------------- ------------LLLVNLFILLSVVCVLLNLAGFILCCQGAQLVSSVMHCQL--AEAGD- -VCNCCAETPSTKCEE-EKMLKIYPGYSCNTMRLLLKKVLFALCALNAVTTAVCLVAAAL RYLQIFGARRPCLE-EPRPIAEEAEDPQQVPDPDEFVPPAPPPSYFSTFCSYTPRLARRM FGDSVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------A-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------G------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------PSNMAGSQEEQ---------------------------- ------------------------IQPADVTRRSTEHHDSRTLGADSCLQTAVVTPVPPP AAVHPGRRAQRLS----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----QHLR----RSSSDPV-L-LDLSAK----V--------LSC---------------- ----------------------------------------------------------EA ATQTEARPET--------------AT------------VTLRR----GR---GPR--R-P RPSSLVDYQSYRDTKLLVTRFLEQSS--GSLMPEVQELINNIKSVLRSDQEHMEEAVRCA SFI----------------------DQV-------------------------------- -----------I-TGSEV-------------------------------KCLQPRQTQLE A-------------------LDGPAQ---------------------------------- -------TV--PRRKRPGQLHLLSCGDLSTFT-W-------------------------- ------------------------------------------------------------ --TDVRTATHASSSRGSQASSRASSR-T-EHERPHSLIGVF------------------- ----------------------RETVL >ENSCHAP00000054008 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCRVSRVSL APPLGDPS---------------------------------------------------- ---------------------------YRSR-RGC------------------------- -----------------------------------IPTPG------------------SR M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------P----------------GSQSRLI----P--- --------------------ALLPGRPLLSLGLLQLALGCSM---------VALSFGALS ISNSPPVRNSCPFWAGSSVILSGIIGLTTWRRPM-------------------------- ------------LLLVNLFILLSVVCVLLNLAGFILCCQGAQLVSTMTNCQL--SELGD- -ICNCCAETPSTKCEE-DKMLKMYPGYSCNTMRVLLKKVLFALCALNAVTTAVCLVAAAL RYLQIFSARRPCME-EPRSAVEEAEEQPRPPDPDEFVPPAPPPSYFSTFYSYTPRLARRM FGDSVIPLPHIYGARIKGVEVFCPLDPPPPYEAVPGVSNPSPAQETQIQMTDLTDLTELT EVTDGLTDQSEAATSITDSCLQTVTSSAAEAPAATGTGRRTQKRQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------LR----RSNSDPV-F-LDLVAK----V--------LSC---------------- ----------------------------------------------------------EA ATQTDTRTATD------------QAT------------VTLRR----GR---VPR--R-P RPTSMVDYQSYRDTKLLVARFLEHSSSWSSLEPEVQELVDSIKSMLRSDEEHMEEAVRCA SII----------------------DQV-------------------------------- -----------I-TGSEVTTSQPAPV-------LQP-AALAVTPAPEPL----------- ------------------------AQ---------------------------------- -------TL--PRRKRPGLLHLRSCGDLSTFT-WVELQLGA----------GTGTGERRH GSRTAS-------SRLGS------------------------------------RAGSSR LG---------------------------EHDRPHSLIGVF------------------- ----------------------RETVL >ENSPNAP00000037669 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLSVVLPGSCCRLAGASF APHFAEPS---------------------------------------------------- ------------------------------------------------------------ ---------------------------------------PSSRGRSRCCSAAAR----WR M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------S----------------GSQARLS----P--- --------------------ALLPARPLLSLGLLQLVLGCSM---------VALSFGALS LSNSPPIRNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------LLLVNLFVLLSVVCILLNLAGFILCCQGAQLVSSTINCQL--SEHGD- -ICNCCADSPSSLCPE-EKLIKIYAGRSCETMRMLLKKVLFALCALNALTTAVCLIAAAL RYLQIFSARRPCTE-ELRNVPEEGEEQQRTPDPEEFVAPAPPPSYFSTFYSYTPRLARRM FGDSVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------AAGENQ--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TVLA--------QDSELQVTELTE----------- ------------------------------------------------------------ -----G-----------------------LSHCSETNT-SDDRCLQTSVHSST------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------QPCQ TTSTASSSRKT------------------------------------------------- --HRQRLR----RSNSDPV-L-LDLAAK----V--------MSC---------------- ----------------------------------------------------------EA ATQTEISPGTGPT---------GKAT------------VTLRR----GK---GPR--R-P RPASMVDYQSYRDTKLLVARFLQQSS--CSLTPEVQELINSIKTVLRSDEEHMEEAVRCA SFI----------------------DQV-------------------------------- -----------I-TGSES------------------------------------------ ------------------------SQAPTVQARQPQLEC--------------------- ----TSNTL--PLRKRPGLLHLRSCGDLSTFT-WAELQVG-------------------- -----STSRSRFTSRMGS------------------------------------RAGSRR LG----------------------------QERPHSLIGVS------------------- ----------------------RETVL >ENSIPUP00000023945 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCRLTGASL APQFADPS---------------------------------------------------- ---------------------------RRSR---C------------------------- -----------------------------------MATVP------------------WR M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------R----------------GSESRLV----Q--- --------------------PLLPARPLLSLGLLQLVLGCSM---------VALSFGALS LSNSPPVRNSCPFWAGSSVILSGIIGLTTWKRPM-------------------------- ------------LLLVNLFVLLSMVCILLNLAGFILCCQGAQLVSSTIHCQL--DGNSD- -ICNCCAESPSK-CQD-EDVIKIYAGHSCASMRVLLKKVLFALCALNALTTVVCLIAAAL RYLQIFSTRRPCME-EPRNVAEE-EEQPHIPDPDDFVPPAPPPSYFSTFYSYTPRLARRM FGDSVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------A-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------ARQAEPSQVQDPEVQVTDLTE----------- ------------------------------------------------------------ -----G-----------------------VLHCSEMDTASDERCMQTAVSSSSPPSQSI- ------------------------------------------------------------ ---------TG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------RKPC- ------------------------------------------------------------ ---RQRHR----RSNSDPV-L-LDLTAK----V--------MSC---------------- ----------------------------------------------------------EA ATQTEVGPG----------------TAVVSRHETEHPVVTLRR----GR---GHR--R-P RPSSMVDYQSYRDTKLLVARFLQQQSP-CSLTPEVQELINSIKSVLRTDQEHMEEAVRCA TFIQQVMSVSESGQARASCVRETQPD---------------------------------- ------------------------------------------------------------ --------------------------------------C--------------------- ----TSVTL--PLRKRPGLLHLRSCGDLSTFT-WAELQV--------------------- -----------------SGQGRP---------------------SSRAHSRTGFRTGTRR LA----------------------------QERPHSLIGVS------------------- ----------------------RETII >ENSSFOP00015018982 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------LLLVNLFVLLSVVCVLLNLAGFILCCQGAQLVSSMSSCQL--SDIGD- -VCLCCADSPSTKCPE-EKLLKLYPGHSCNTMRVLLKKVLFALCALNALTTAVCLVAAAL RYLQIFAARRPCSPDEPQPVVEEGEEPAHVPDPDEFVAPAPPPSYFSTFYSYTPRLARRM FGSSVIPLPHIYGARIKGVEVFCPLDPPPPYEAV-------------------------- ---------------------------------------------AGQPDH--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TSL---------QESQVQVTDLTE----------- ------------------------------------------------------------ -----G-----------------------L------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SDGSGARCGAGSLHM------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PTLLQGQARPSKAFLP----------------- -----------------------------------------------------ACRKAC- ------------------------------------------------------------ ---RQQFR----RSNSDPV-LQLAAKST----V--------LSC---------------- ----------------------------------------------------------EA ATQTDTRLEA--------------GA------------VTLRR----GR---GPR--R-P RPTSMVDYQSYRDTKQLVSRFLEHSS--SSLTPEVQELVDSIKTMLRSDQEHMEEAVQSA SFI----------------------DKV-------------------------------- -----------M-TNTQAPPAQP------------------------------------- -----------------------------PQPPQPQAAT--------------------- ----TSQTL--PQRKRPGLLHLRSCGDLSTFT-KEEPQS--------------------- -----------------ANSRSG--------------SPMVSTTG--------------- ------------SSSGSRTGSRTGSR-A-EHERPHSLIGVF------------------- ----------------------RETIL >ENSLOCP00000011533 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGVSL ASQLADPS---------------------------------------------------- ---------------------------FRTR-HRC------------------------- -----------------------------------IS-GV------------------SR M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------P----------------GSQSRLL----P--- --------------------ALLPGRPLLSLGLLQLVLGCSM---------VALSFGALS LSSSPPIRNSCPFWAGSSVILSGIIGLTTWRRPV-------------------------- ------------LLLVNLFVLLSVVCVLLNLAGFVLCCQGAQLVSSMSSCQL--SEVGD- -VCQCCADTQSAKCPE-EKLLKLYPGNSCSTMRMLLKKVLFALCALNALTTAVCLVAAAL RYLQIFAARRPCIQDEPRPTVEEGEEPARVPDPDEFVPPVPPPSYFSTFYSYTPRLARRM FGNSVIPLPHIYGARIKGVEVFCPLDPPPPYETV-------------------------- ---------------------------------------------ANQSDN--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------T---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EQGAAAEVAELTGGLIET SDTDGCCQASNTLLSQPKPGQVSG----------------------------VACRRSC- ------------------------------------------------------------ ---RQLLR----RSNSDPV-L-LDVTTK----V--------LSC---------------- ----------------------------------------------------------EA ATQTEARPEL--------------AT------------VTLRR----GRRYQGPR--R-P RPSSLVDYQSYRDTKQLVAQFLEHSP--CSMTPEVQEVVNSIKTVLRSDQEHMEEAVLSA SFI----------------------DQV-------------------------------- -----------I-TGSQA------------------------------------------ ------------------------------RRPQPSPER--------------------- ----TVHTL--PSRKRPGLLHLHSCGDLSTFT-AAEPQP--------------------- -----------------AERRRP------------------------------------- -------------------------R-A-AQDRPRSLIGVF------------------- ----------------------RETVL >ENSPKIP00000014381 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SLPVVLPGSCCPVAGVSL ASQLTDPA---------------------------------------------------- ---------------------------HRSR-PRC------------------------- -----------------------------------ISAGA------------------TR M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------P----------------ASQSRLI----P--- --------------------ALLPGRPLLSLGLLQLVLGCSM---------VALSFGALS LSSSPPIRNSCPFWAGSSVIVSGIIGLTTWRRPM-------------------------- ------------LLLVNLFVLLSVVCVLLNLAGFILCCQGAQLVSGKPHCQL--SERGD- -VCICCADGFSSGCSD-EKMFKLNPGNSCETMRVLLKKVLFALCALNALTTAVCMVAAAL RYLQIFAARRPCAQDEPRSAAEEGEDTANVPDPDEFVPPAPPPSYFSTFYSYTPRLARRM FGDSVIPLPHIYGARIKGVEVFCPLDPPPPYEAI-------------------------- ---------------------------------------------AGQSENISSQ----- -----------------------TEVQM-------------------------------- ----------------------------TIVTEGLSESCDPQTTRAGCSHTPT------- --------PP-------------------------------------------------- ---QVQRRPVQALLLAARDPFRQHV----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------R----RSNSDPI-L-LDLTSK----V--------LSC---------------- ----------------------------------------------------------EA ATQTDSRPEV--------------AT------------VTLRR----GVSH---R--K-P RPSSMVDYQSYQDTKQLVARFLEHSS--CSLTPEVQELVNSIKTVLRSDQEHMEEAVRSA SFI----------------------DQVMMTDPQGPPAQPAQPVQPAQPAQPVQPAQPVQ QAQLQPTVASQ------------------------------------------------- ------------------------------------------------------------ -------TL--PLRNRPALLHLRSCGDLSTFT-KEEP----------------------- ----------------------PSEERK---AGSR-KS---------------------- ----------------SRAGSRAGSR-A-EHERPHSLIGVF------------------- ----------------------RETVL >ENSECRP00000002642 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------M----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------SRLA----PSER PRAPCPSRI----------AAQLPGRPLLSVGLLQLLLGCTM---------VALSFGALS LSMSPPVRNSCPFWAGSSVILSGIIGLTTWKRPQ-------------------------- ------------LLLVNLFVLLSVVCVILNLAGVVLCCQGAQFVSNMSNCYM--SE--DN AICMCCEDTQSAKCTD-DKLLKLFRTHSCSTVHILLKKVLFGLCALNALSTAVCMVAATL LYLQIFRARRPCLE-EPRLAVEEVEERNQIPDPDEFVPPAPPPSYFSTFYSYTPQLARRL LGNGVIPLPHIYGARIKGVEVFCPLDPPPPYEEV-------------------------- ------------------------------------------------------------ -------------------------------QRS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TGDEEIIGPQGRSHEPADSEVSA-------------------------- ----NG------------------------------------------------------ ----------------YDC----------------------------------------- ---------TG------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------P-------------------------------------- --------------SIIVVH---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ --------------------------------------------QSSMTVLRQFH----- ---RQMLK----RSISDPA-L-LDMSTT----V--------KSC---------------- ----------------------------------------------------------EA ATQTETRPDL--------------SM------------VTLRH----GK---KGRIRRAA RPRSMVDYETYRDTKEIVARFLEQTP--NTMPPEVKELVESIKIVLKSDEEHMEEAVLSA NFI----------------------DQA-------------------------------- -----------I-S-----SQQHS------------------------------------ ------------------------------------------------------------ ---WTANTL--PCMRRPRLIHLRSCGDLSTFT-RAK-------------------ADHRQ GE---------------------------------------------------------- -----------------------GQR-A-EPERPHSLIGLV------------------- ----------------------QETML