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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GS----------------PA-R PSIPIN------------------------------------------------------ -------------KKPNMVGKPGE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------T------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------VICLYS----- --A--------------------------------------------------------- ------------------------------------------------------------ ------------------PKQET---WEDSELFKPQPSSDVDALGKKRYVAPHVIYQTGK KPDEPCSITSSLNYFPE-DEP-GESNVTAPPKSPPSNLTVVTVE-GCPSFIILDWEKTDN DT-T-E------------------------------------YEVIS-TAIGP-DG-KQV SIVTTNQTHTAVENLKPESSYEFKVKPKNELGAGPPSEPVSFNTESADPRVSENVS---- -------GKDAIWTQFPFT-T--DSHSDCHGKQYVKRTWYRKFVGIQLCNSLRYKIYLSD SLNG----------------------------------------KFYNIGDQSGFGEDHC QFVDSFLDGRTGRHLRADQLQSRLGFYRALRQEPVHFGQIGGHSHINYVSWYECGTPIPG KW >ENSSLDP00000019792 ---------------------MVG------------------------------------ ------------------------------------------------------------ ---------VALNLRV-------------------------------------------- ------------------------------------------------------------ ------------VFLLLGGTILLNG----------------------------------- ----------------------------------------ISAQRI-------------- --------R--------------------------------------------------- ----------------------------------------V------------------- --------------------------------------------------------R-RQ 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----------------------------SELLHSSVIRLVCLSSCP-------------- -------------------HPTCCKSPLSSVSLHDRSACQPVQTQTWLEFPIQYFFECTH QAK--------------TNTDQF------------------------------------- --PMTSVPLF--------------------------SFIP-------------------- ----EKGNTIRNNTTQPADIPTPALPKL-------------------------------- -------------------------------------LS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TKA------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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--------------------------------------------------------R-RQ NMKVRINATGDTVVMKFLRPSPDMKLEGYILGYGSSMFSKQFIQLPENGEPYEAEL--DA EPKYLVAVQPIPANDVKKHCTGKVNLEKPLHLVIGSVSPTTVLLSWGNHLKTPYV-GNIM NECLED-GFYTIRYR--ER--NRK-WIYQTCPTSDTVIDNLKPNTPYEFGVRSNKDDQS- GMWSKPVVH-----------------------------------------N--------- ------------------TNMA----------NKNAQMPYKL------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------VNRQ------------HHRGVSPPK----PALWSRP-- ---GL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GS----------------PA-R PSIQIN------------------------------------------------------ -------------KKPNLVGKPGD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TDKVNNLKQTDK-------------- ------------------------------------------------------------ ----------------------LPILKPKVPAVTA-----KPTK---------------- ----PE--R-K--HTTT-VAPAT------------------------------------- ---------------------------------------------A-------------- --A--------------------------------------------------------- ------------------------------------------------------------ ------------------ARQES---WEDSDLFKSQPTSDVDALGKKRFVAPHVVYQTGK KPEEPCSITSSLNYFLE-AEP-GEANVTSPPRTPPSNLTVVTVE-GCPSFIILDWEKTDN DT-T-E------------------------------------YEVIS-TAKGP-DG-EQV SILTTNQTHTAVENLKPESSYEFKVKPKNELGAGPPSEPVSFNTESADPRVSENVS---- -------GKDAIWTQFPFK-T--DSYSDCHGKQYVKRTWYRKFVGVQLCNSLRYKIYLSD SLNG----------------------------------------KFYNIGDQTGFGEDHC QFVDSFLDGRTGKQLRADQLPNRPGFYRAVRQEPVHFGQIGGHSHVNYVSWYECGTPIPG KW >ENSNBRP00000016306 ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------DYCSFF LFSLFAYFYFSSSLGNREVAHTAQHKSGCNKIMFLSLSGS----------------PA-R PAIQIN------------------------------------------------------ -------------KKPNLVGKPGE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TDKVNNFKQNDK-------------- ------------------------------------------------------------ ----------------------LPVLKPKVPAVTA-----KPIK---------------- ----QE--R-K--QTTT-ATPTT------------------------------------- ---------------------------------------------TGTKI----STWQSS SN---------------------------------------------------------- ------------------------------------------------------------ -------------------------------LFKSQPSSEIDAMGKKRYVAPHVIYKTGK KPDEPCSITSSLNYFPE-DEP-SETNVTSPPKTQPSNLTVVTVE-GCPSFIILDWEKTDN ET-T-V------------------------------------YEVIS-TAKGP-DG-EQV SILTTNQTHTAVENLKPESSYEFKVKPRNELGSGPPSEPVTFNTESADPRVSENVS---- -------GKDAIWTQFPFK-T--DSYSDCHGKQYVKRTWYRKFVGVQLCNSLRYKIYLSE TLNG----------------------------------------KFYNIGDQTGFGEDHC QFVDSFLDGRTGRQLRADQLPSRQGFFRALRQEPVHFGEIGGHSHVNYVSWYECGTPIPG KW >ENSMAMP00000033708 ---------------------MAT------------------------------------ ------------------------------------------------------------ ---------VAA-LRL-------------------------------------------- ------------------------------------------------------------ ------------VLLLLGGTILLGG----------------------------------- ----------------------------------------IPAQTV-------------- --------R--------------------------------------------------- ----------------------------------------V------------------- --------------------------------------------------------H-RQ NMKVQINATGDTIIMKFVRPSPNTKLEGYILGYGRSMFSKQFIPLPENGEPYETEM--DA EPKYLVAVQPIPANDVKKHCTGKVNLEKPLHLVIGSVSPTAVLLSWGNYLKTPYE-GNIM NECLED-GFYTIRYR--ER--NRK-WIYQTCPTSDTVIDNLKPNTAYEFGVRSSKDDRN- SMWSKPVIH-----------------------------------------N--------- ------------------TNMG----------NKNSQKPYKL------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------RNPLA------------------------------- ------------------------------------------------------------ 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------------------------------------------------------------ ---------------------------------------------------------ESQ QDTLPLPGSA-------------------------------------------------- -----------------------------------HSN---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------WPHV--SLDKGNSFRND-----------------TNRPADPR----------- --------------------------------------------PSISLQLLPTRVPPVS T----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TPLTKFPSSGDS------------------------------------- ---------------------------------------------------------VQA 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------------------------------------------------------------ ------------------------RKT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AAVRA QDGSSLLRSALATERVRPSTWGESS----------------------------------- RNV------------SPSLPVKTSSPAASPVS------MRNPLFPFSNSFRQLHS-PS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------RSSSSSPTSGILG---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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---------------------M-------------------------------------- ------------------------------------------------------------ ---------MALLLRV-------------------------------------------- ------------------------------------------------------------ -----------LLLLLIGGTVLLGG----------------------------------- ----------------------------------------SPAQRI-------------- --------R--------------------------------------------------- ----------------------------------------V------------------- --------------------------------------------------------R-RQ NMKVRINATGDTIVMKFVRPGPDVKLEGYILGYGRSVFSKQFIQLPENGQLYETEL--DA EPKYLVAVQPIPVNDMKKHCTGKVNLEKPLHLVIGSISPTAVLLSWGNHLKTPYE-KNVM SECLED-GFYTIRYR--ER--NRK-WIYQTCPTSDTVIDHLKPDTQYEFGVRSNKDDRS- GLWSKPVIH-----------------------------------------S--------- ------------------TNTA----------NKNTQKPYKP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------RKTLT------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------N------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PM------- 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------------------TRFET---WENSSVFSSIPASKVDAMGKERFIAPHVVYKTDK KPDEPCSITTSLSYFPE-DEA-TETNVTGPPRTAPSNLTVVTVE-GCPSFIILDWEKTDN ET-T-E------------------------------------YEVIS-TTKGP-DG-EKV SILTTNQTHTAVENLKPESSYEFKVKPKNELGEGPPSEPVSFNTESADPRVSENVS---- -------GKDAIWTQFPFK-T--DSYSECNGKQYVKRTWYRKFVGIQLCNSLRYKIYLSD SLNG----------------------------------------KFYNIGDQTGHGEDHC QFVDSFLDGRTGTQLPADQLPTRTGFYRAVRQEPVHFGQIGGNSHVTYVAWYECGTPIPG KW >ENSEEEP00000047281 ---------------------M-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------KLM--------KQFNNGSPLLYVSS--------------------------- ---------------------------------------TV------------------- --------------------------------------------------------R-RQ NMKVRINATGDTVILKFVRPNPDVKLEGYILGYGSSMFSKQFIQLPENGELYETEI--DA EPKYLVAVQPIPANDVKKQCTGKVNLEKPLHLAIGTVSPTSVLLSWGMYVKTPYE-GNIM KDCLED-GYYTVRYR--ER--NRK-WIYQTCPTSDTVIDNLKPNTPYEFGVRSNKDDRS- GVWSKPIIH-----------------------------------------S--------- ------------------TNSA----------DKNLQKTYKPSRTKPVVPLNNRTQTQLP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------P------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------LHTNP------------------------------------- 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NDCLED-GYYTIRYR--ER--NRK-WNYQTCPTSDTVIDNLKPNTPYEFGIRSNKDDRS- GGWSKPVIH-----------------------------------------N--------- ------------------TNMG----------DKNMQKPFKPS----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------HSPP RLGDPSRRHGGSSAGR---------PNNALKNPNVVGMHERIGKDMKPDVN--------- ---------------------------------QDKAS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ILMPKLPPVTA-----KPSK---------------- ----PK---------TT-SAPSV------------------------------------- ---------------------------------------------T-------------- --A--------------------------------------------------------- ------------------------------------------------------------ ------------------PKYET---WENSSSFSPVPASKVDAMGKERYIAPHVVYKTDK KPDEPCSITTSLTYFPE-EEG-GEQNVTNPPKTAPSNLTVVTVE-GCPSFIILDWEKTDN ET-T-E------------------------------------YEVIS-TTKGP-DG-EQV SILTTNQTHTAVENLKPESSYEFKVKPKNELGEGPSSEPVSFSTESADPRVSENVS---- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---GTGVHRPSVPEVPRS------------------------------------------ -------------------------------------------------------PISSS VRLA----------GRNST--------------GSRAKAPPHSTRNNGRPF--------- -------SPPKIFTSP-HS----------------SH----------T------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----EGNG--------------------------------------------------- -DPNFL------SKRPNLVGKPSD------------------------------------ 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---------------------L-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SITTAHHLSSESALVWSLFYLCTSQISVKE-RQ NMKVRINATGDTIVMKFVRPNADTKLEGYILGYGSSMFSKQFIQLPENGQPYETEF--DA EPKYLIAVQPIPTNEVKKHCTGKVELQKPLHLVIGSVTPTSVLLSWGTLLKTPYE-GNIM NDCLED-GHYTVRYR--ER--SRK-WNYQTCPTSDTVIDNLKPNTVYEFGVQPNSKDGT- GLWSKPVIH-----------------------------------------N--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SVP-------------------- ----------------------------------------------NANVDKQGGHLQ-- -----------------------------------------QRPVSQPHAEP-------- --------------------------------------------------QPNSRLQPYY RP---------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------P----------- --------------------------------------------------------QTKP QP----------------------------QVKPQVKPI--------------------- ------------------------------------------------------------ ----------------------------------------PQTQP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q--------------------------------------- ------------------------------------------------------------ ------TYTTSRPKLQTQPQPQAA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------QPIPQTKLQTQPQ--------- ------------------------------------------------------------ --------------------------------------PQ-------------------- ------------------------------------------------------------ ------------------ATPQ-------------------------------------- -------------------------------------------------------PIPQT PPQ-----------------------------------------------PQTVLTKLQT Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------PQPQATPQPI-PQT---------- 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-----------------APRFDI---NENSSIFRPLPASDVDIMGKKRFVAPHVIYKTDK KPDEPCSITSSLAYFPD-EEG-GDQNVTGPPRIPPSNVTVVTVE-GCPSFVILDWQKSDN ET-R-E------------------------------------YEVVS-TTKGP-NG-QEV SILTTNQTHTAVENLKPESSYEFKVTPKNELGTGPSSDPVSFSTESADPRVSEYVS---- -------GKDAIWTQFPFK-A--DAYSECSGKQYVKRTWYRKFVGIQLCNSLRYKIYLSD SLNG----------------------------------------KFYNIGDQTGHGEDHC QFVDSFLDGRTGTQMLADQLPGRPGFYRALRQEPVSFGEIGGKSHVTYVGWYECGTPIPG KW >ENSGAFP00000031473 ---------------------M-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------PQQHSHCFLLLFLTAFLIG M----------------------------------------------------------- -----------------------------------ALSLPSTSHRR-------------- --------R--------------------------------------------------- ----------------------------------------V------------------- --------------------------------------------------------R-RQ 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----------------------------------------ISTAGLQDKVIRRIVK---- ------------------------------------------------------------ ------------------------------------------------------------ -----------Y------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PI------- ------------------------------------------------------------ ---SP---------------VKTFTPA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------PPSFQ------------------------------------------------- ------------------------------------------------------------ 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---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---EGLGEVAIASVPGYQGKLEYHEDYPKEIPHLELKTQTEPNSKHLQHP---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QPK--------------------------------------- ------------------------------------------------------------ -------------------------------------------------NLGK------- ---KHQKPTKTPRIKNQRGVANLQSHPQTEFPKKDPFRPK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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---------------PG------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ANGA------------HHRGNALPK----PVAWSRE-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KPVQ------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------R PPVPGN------------------------------------------------------ -------------KRPNLVGKTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------HDKPIDLKQGGKESTLKS-------- ------------------------------------------------------------ -----------------------------FLPVTP-----KPKH---------------- ----QH--Q-Q--QTTT-VLPIV------------------------------------- ---------------------------------------------N-------------- --S--------------------------------------------------------- ------------------------------------------------------------ ------------------SRFDL---NENSSIFSSLPASDVDIMGKKRFIAPHVIYKTDK KPDEPCSITSSMAYFPD-EEG-NDLNVTGPPRTPPSNLTVVTVE-GCPSFVILDWEKSDN ET-R-E------------------------------------YEVVS-TTTGP-NG-QEV SILTTNQTHTAVENLTPDSSYEFKVTPKNELGVGPSSDPVTFNTESADPRVSEQAS---- -------GKDAIWTQFPFK-S--DAYSECNGKQYIKRTWYRKFVGIQLCNSLRYKIYLSD SLNG----------------------------------------KFYNIGDQTGYGEDHC QFVDSFLDGRTGTQMLADQLPSRQGFFRALRQEPVSFGQIGGKSHVTYVGWYECGTPIPG KW >ENSXMAP00000011233 ---------------------M-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------PQQHSHCFLLLFLTAFLIG M----------------------------------------------------------- -----------------------------------ALSLPSISHRR-------------- --------R--------------------------------------------------- ----------------------------------------V------------------- --------------------------------------------------------R-RQ NMKVRISASGDTIVMKFLHPITDTKLEGYILGYGSSMFSKQFIQLPENGQPYETEF--DA EPKYLVAVQPIPANEVKKQCKGKVELQKPLHLVIGSVTPTSVLLSWGMLLKTPFE-GNVM NDCLED-GHYTVRYR--EK--NRK-WNYQTCPTSDTVIDNLKPHAVYEFGVQPNSKDGV- GAWSKPVLH-----------------------------------------N--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------ISTAGIQEKVIRRILK---- ------------------------------------------------------------ ------------------------------------------------------------ -----------Y------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PI------- ------------------------------------------------------------ ---NP---------------VKTFTPA--------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------W TTP--------------------------------------------------------- ------------------------------------------------------------ --MIHSE----------------------------------------------------- -PKPQPSLKTKPQNELLIQLQPKTQTKLQAKLQTTTLPLP--VMHHETTQSAP------- ------------------------------------------------------------ --------------------------------------------------LYVQYEEP-- ----------APAEVR-------------------------------------------- -----------------------------PERPLHMDTNLFKNPQTPP------------ ---P---H------SPTTPQTQ-PQLI--------------------------------- 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-------------KPVQ------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------R PPVPGN------------------------------------------------------ -------------KRPNLVGKTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------HDKPMDLKQGGKESTLKS-------- ------------------------------------------------------------ -----------------------------FLPVTP-----KPKL---------------- ----KH--Q-Q--QTTT-VLPVV------------------------------------- ---------------------------------------------N-------------- --S--------------------------------------------------------- ------------------------------------------------------------ ------------------SRFDL---NENSSIFSSLPASEVDIMGKKRFIAPHVIYKTDK KPDEPCSITSSMAYFPD-EEG-SDLNVTGPPRTPPSNLTVVTVE-GCPSFVILDWEKSDN 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--MIRSE----------------------------------------------------- -PKPRPSVKTKPQNEQLIQLQTKTQTNLQAQLQTTTLPLL--VTHHETTQSAP------- ------------------------------------------------------------ --------------------------------------------------LSVQHEEP-- ----------APTEVR-------------------------------------------- -----------------------------PERPPHT--------QTPS------------ ---P---H------SPTTPQTQ-PQLI--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------QP------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------TQKPKAILHQSKATPQH-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------TQKPKAILHQSKATPQH-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------QPK--------------------------------------- ------------------------------------------------------------ -------------------------------------------------NLGK------- ---KQQKPTKKPRIKNQRGVANLQSRPQTQFSKKDPFQPK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------DLPKEH-------- -QP--------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------GFQTQPQTRTKTDHSKG---- 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---------------------------------------------N-------------- --S--------------------------------------------------------- ------------------------------------------------------------ ------------------SRYDL---NENSSIFSSMPASEVDIMGKKRFIAPHVIYKTDK KPDEPCSITSSMAYFPD-EEG-SDVNVTGPPRTPPSNLTVVTVE-GCPSFVILDWEKSDN ET-R-E------------------------------------YEVVS-TTTGP-NG-QEV SILTTNQTHTAVENLTPDSSYEFTVTPKNELGVGPSSDPVTFNTESADPRVSEQAS---- -------GKDAIWTQFPFK-S--DAYSECNGKQYIKRTWYRKFVGIQLCNSLRYKIYLSD SLNG----------------------------------------KFYNIGDQTGYGEDHC QFVDSFLDGRTGTQMLADQLPTRQGFFRALRQEPVSFGQIGGKSHVTYVGWYECGTPIPG KW >ENSFHEP00000010479 ---------------------M-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------HQHAHCFLLLFLTTFLTG M----------------------------------------------------------- -----------------------------------VQSLPSTSHRS-------------- 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------------------------------------------------------------ ------PPLFP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------FP----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------PQH----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------APN------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRMRSK------------------------------------ -------------PSTSRIKI--------------------------------------- ------------------------------------------------------------ -----------------------------------------------PQAT--------- ------------------------------------------------------------ ------------------------------------------------------LAP--- ------------------------------------------TTAAKQELLPTPGSKL-- SVINKQPI---------V------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------AHNPG- GELSRPVLT--------------PFPE-VPLAPEVH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --SEVLVAVTMASVPSYQDKLENHGDYPKQLPLAQLKTQTEPNSK--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------HPQ-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PMPKP---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------QP-------------------- -----------------------------------PLKPLDESIPQPHTTSQPDLQTIPE PQMT------------IQPVPQTNPLSQFEEEPDFQSLP--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------L TTP--------------------------------------------------------- ------------------------------------------------------------ --MLPSE----------------------------------------------------- -VKPQPSPQTKHQIQLLTQLQPKTQTKVQ-----TQLPLPYAVTHHQATQPAP------- ------------------------------------------------------------ -----QHI--------------V-------------------------------YEEP-- ----------APTKIQ-------------------------------------------- -----------------------------SRPPLQPDTHFFKNPQNQS------------ ---P---H------PPTTPQTQ-PQLI--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------QLTQKPKIIFDQSKSTPLL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------RPK--------------------------------------- ------------------------------------------------------------ -------------------------------------------------NLGK------- ---KHQKP------KNQHSLANLQSRSQPQFPQKDHVQPE-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------T------------------------- -----------------------------------DPS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------SKQLTCHWSKLGYIKTVALLEESNNLNILISVPFSTKGLQY RVFKYYCLFLFVLTSQLSAQMII------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------FLLFMCCAFSRCLTKLYLHILGSSRLHVQCLIHNCMLGNSNSF 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------TSLQLKL---------------------------- ------------------------------------------------------------ -----------------------------PD----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------H--------TSPQCETPQ-------SLQIQNKSIALLNQNSSNQFSNLISITA NYRNKLKINVTMRSNVQFIHKRIQQ-------------------------------EP-- ----------------------------------------------ASING--------- ------------------------------------------------------------ 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---------------------NNASI---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------ESELLL------- ------------------------------------------------------------ ------------------HPK--------------------------------------- ------------------------------------------------------------ -------------------------------------------------DLDK------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RNPF----------------- --------------------------------RNFT------------------------ -APT-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ANP---------------------SSPSIHQPYRKPSM--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RTF FNSSNGLTRP--GHVPPG------------------------------------------ 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RPTK-------------------------------------------------------- ------------------------------------------------------------ --------PVTESPQTFSPSMPLLSSVTQNRPASILRPPSPTQRVTQVKDISNHKTLKPE NFLGSKKPITESPQAFSSSVPLLPRVT-------QSRPASLLRPPAPSPIPTVTLDIHKP LKPEIFLKPEKPITESPSAFSASVPFLSSETQSSLISDLRNPAPRPTQRVVQVTDIHKPL KPE----------------------------------------SVLR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PK------- ------------------------------------------------------------ ---------------------KPVT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------HPGTTKTQPTTTRSQ-PQPIK-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------TQ--------- --SN------P------------------------------------------------- ---------------------NKHTEKS-------------------------------- --------QPKTV----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------QP------------------------------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KPIK------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------R P----------------------------------------------------------- ------------RKEPDL------------------------------------------ ------------------------------------------------------------ -----------------------------------------------NEIKK--QKNK-- -----VPKNGGKGKT-------------------HDKVVDLKVVDALPFQKP-------- ---------SD------------------------------------------------- -----------------------------APPTTELYQKPTPA----------------- ---------------TT-PFFAV------------------------------------- ---------------------------------------------N-------------- --G--------------------------------------------------------- ------------------------------------------------------------ ------------------SRYYM---GDNSSVFSSVPVSEVDPMGKKRFVAPHVIYQIDK PPEQPCSVTHSLSFFPD-EEN-GVANISGPPKTPPTNVTVVTVE-GCPSFVIVDWEKTDN ET-T-E------------------------------------YEVTS-SVINP-NG-QVV SVVKTNQTHAAVENLKPESSYEFTVTPKNELGSGPSSEPVSFSTESADPRVREVQT---- -------GKNAIWSSFSFD-A--DSYSECTGTQYVKRTWYRKFVGIQLCNSLRYKIYLSD SLKG----------------------------------------KFYNIGDETGYGEDHC QFVDSFLDGRTGSLLPPHQLPLKQGYFRSIRQEPVKFGKIGGRTQINYVSWYECGVPIPG SW >ENSDARP00000083976 ---------------------MNS------------------------------------ ------------------------------------------------------------ -----------------------VLFSSRKGDNMQLF----------------------- ------------------------------------------------------------ -----------LLLLFLSKIFLLRV----------------------------------- ----------------------------------------TSATTI-------------- --------K--------------------------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------FKELNQA-------------------------------------- -----------K------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PK------- ------------------------------------------------------------ ---------------------KPIL----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------TSTVQSQSPT-----------------NDP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------TTS----------------------------------------- --------------------------------------QPD-----------LFTEQHTS T----------------------------------------------------------- -------------------------------------TP--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -QQ--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------PA------------------------------------------ ----------------------------------TTQQQSSTTQQQTSTT---------- ------------------------------------------------------------ -----------------------------------------------------QPT---- --TQEYIKTQISTKDPPYTAKQQFSETTS---------PVSTTSPI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTS-------------------------------------- ------------------------------------------------------------ -TKP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------IKPRPSRMPS----------------GNGMG T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPK------------------------------------------- -------------------------------------------------------PSGT- --------------GRSVPVD--------------------------------------- ---------------S-YS----------------------------T------------ ----KK-------P---------------------------------------------- ------------ATIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RLPPM---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------IPSQR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGPVTSPPLRTTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KHTETPS-K----------- --------R---PEIDT-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-KEV---LGNTTDFSSSPTKETDQLGKPRFRGPYVRY-IPK PENSPCSITDSVKRFPI-EEA-PEGNATSSPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASKTVAFSTESADPRVSEPIS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSMMMP00000017223 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KP SLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNVSPNQYFPLPTEGKYTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIIG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------K------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKASTKSPDKTPY GGPILVHLIIPGPNDTT-VKLPT-SIMF-----------EISDAIKTQLAKNETLALPAE SKTPEVEKIPAQ---------------------------------------PV------- --------TV-------------------------------------------------- ---IPEIVPR---------TIKPTVSSEVDVSETTL-VLSERTPEALQTILMPKFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKSLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------DFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPRSTFAS-SEKPW----------- -MVPTAKPSEDSKVVQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSSTTSDETEI SEAH-TATSDPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAAS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKMETFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTP---------- -----------------------VPQR--------------------------------- ------------------------------------------------------------ --TTSTPST--------------------------------------------------- ---PKRRP---------------------------RPQT--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEPQ---------------TPPTPQ------------------------------ ------------------------------------------------------------ ------TTKA-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RRPD------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TVQLELLVPTVAPKPT------KRPK TT---------------------------------------------------------- -------QRPDV------------------------------------------------ -PQIQPV------LELD------------------------------------------- -------------------------------------------------TVETEAPSSTI ATTKDIEPVILKTEAPGTTLA--------------------------------------- ----------------PKKPQRARTR--R----------------PRPK-HKTTPSPKI- --PQTKPDFGPVAP------EPSLASIIHPPN------------------------PKTK TMPHSE-------VPQTIL----------------------------VPAMIHE------ ---------------PVVVRTEAPGTT--------------------------------- ---------------------------------------------------LVPTTVFEP VTPVKEAPGAELV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SRTETPVTTLA-TKIS QRTRRPRPRP--KTTTPTPQVPQTKPVPAIVLEPV-------------------TPRPEA PQT--------------------------------------------------------- ------------------------------------------TLAPKTSQWITRSHSRPK PMPSPEAPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------EFEPVTLKTEMWVTTEAPKTSKRTRRP RPKPKTTPS-------------------------------------------P------- -------------KAPQTKPVPATDLEPGSLGTEASETIALATVLEPDTLRTKAPE-TTL APKI-QRTR-------------RPRP--RPKTT-SSPAESQTKP---------------- ----------APTELQTLILKPVTSPSLEMTQSQLVSEVLESVTFSTESSKETI------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------WQTPRAPP---------------------- --------KPKTSPH------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKGP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRATSKPKMS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEALYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VLKDALL-PHKPD----PEV-----SQHESV------------LQPVT FRIEPPETT------------------------------------------IAP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LESRGIPFIPIISPSP- --SQEELQTTL------------------------------------------------- ------------------EETDQTTQELFTTKIPRTTEWAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPV-------------------- ------------------RPRIPG------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NR---------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------IRPKPSGIPS----------------RNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------TKQAPK------------------------------------------- -------------------------------------------------------PSGA- --------------GRNVSVDF-------------------------------------- ---------------T-HS----------------------------T------------ ----KK-------P---------------------------------------------- ------------VPIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RHPAG---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RS--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------GPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SIGI-------------------------------------------- -----ISSGRVTSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPTGIPS-E----------- --------R---PETDK-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LGNTTDISSSPTRETDHLGKPRFKGPHVRY-IPK PDNRPCSITDSVKRFPT-EEA-MEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQVTNQTFSTIENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQITYVQWYECGTTIPG KW >ENSSTOP00000001139 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KP SLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNVSPNQYFPLPTEGKYTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIIG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------K------- -----------K---------------LIPITIIKQ------------------------ ------------------------------------------------------------ -------------------------------------------------AKNETLALPAE SKTPEVEKIPAQ---------------------------------------PV------- --------TV-------------------------------------------------- ---IPEIVPR---------TIKPTVSSEVDVSETTL-VLSETTPEALQTILMPKFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKSLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------DFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPQGTLAS-SEKPW----------- -MVPTAKPSEDSKVVQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSSTTSDETEI SEAH-TATSDPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAAS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKVETFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EIQPTTP---------- -----------------------VPQR--------------------------------- ------------------------------------------------------------ --TTSTPST--------------------------------------------------- ---PKRHP---------------------------RPQT--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEPQ---------------TPPTPQ------------------------------ ------------------------------------------------------------ ------TTKA-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPD------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TVQLELLVPTVAPKPT------KRPK TT---------------------------------------------------------- -------QRPDV------------------------------------------------ -PQIQP------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------WQTPRAPP---------------------- --------KPKTSPH------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKGP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRATSKPKMS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEALYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDALL-PHKPD----PEV-----SQHESV----------------- -----------------------------------------------------P------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPIISPSP- --SQEELQTTL------------------------------------------------- ------------------EETDQTTQELFTTKIPRTTEWAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPV-------------------- ------------------RPRIPG------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NR---------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------IRPKPSGIPS----------------RNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------TKQAPK------------------------------------------- -------------------------------------------------------PSGA- --------------GRNVSVDF-------------------------------------- ---------------T-HS----------------------------T------------ ----KK-------T---------------------------------------------- ------------APIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----GHPAG---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SIGI-------------------------------------------- -----ISSGRVTSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPTGIPS-E----------- --------R---SETDK-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LGNTTDFSSSPTRETDHLGKPRFKGPHVRY-IPK PDNRPCSITDSIKRFPT-EEA-MEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQVTNQTFSTIENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQITYVQWYECGTTIPG KW >ENSUPAP00010009685 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KT SLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNVSPNQYFPLPTEGKYTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIIG----------SKN------------------------- ----------------------KVNGKIQSTYDQIHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------K------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKASTKSPDKTPY GGPILVHLIIPGPNDTT-IKLPT-SIMF-----------EISDAIKTQLAKNETLALPAE SKTPEVEKIPAQ---------------------------------------PV------- --------TV-------------------------------------------------- ---IPEIVPR---------TIKSTVSSEVDVSETTL-VLSETTPEALQTILMPKFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKSLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------DFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPRGTFAS-SEKPW----------- -MVPTAKPSEDSKVVQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSSTTSDETEI SEAH-TATSDLILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAAS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKMETFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTP---------- -----------------------VPQR--------------------------------- ------------------------------------------------------------ --TTSTPST--------------------------------------------------- ---PKRRP---------------------------RPQT--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEPQ---------------TPPTPQ------------------------------ ------------------------------------------------------------ ------TTKA-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPD------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TVQLELLVPTVAPKPI------KRPK TT---------------------------------------------------------- -------QRPDV------------------------------------------------ -PQIQPV------LELD------------------------------------------- -------------------------------------------------TVETEAPSSTI ATTTDIEPVILKTEAPGTTLA--------------------------------------- ----------------PKKPQRARTR--R----------------PRPK-HKTTPSPKI- --PQTKPDFGPVTP------EPSLASIIHPSN------------------------PKTK TMPHSE-------VPQTIL----------------------------VPATIHE------ ---------------P-VVRTEAPGTTLAPKVP--------------------QRT---- --------------------------------RRPRPKPKTTQSPEAPHTELVPSTVFEP VTPVKXAPGAELV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTETPVTTRA-TKIS QRTRRPRPRP--KTTTPTPQVPQTKXVPAIVLEPV-------------------TPRPEA PQT--------------------------------------------------------- ------------------------------------------TLAPKTSQWITHPHSRPK PMPSPEAPESKPVPMA-------------------------------------------- ------------------------------------------------------------ ---------------------------------EFEPVTLKTEMQVTTEAPKTSKRTRRP RPKPKTTPS-------------------------------------------P------- -------------KAPQTKQVPATDLEPGSFGTEASETIVLATVLEPVTLRTKAPE-TTL ATKI-QRTR-------------RPRP--RPKTT-SSPAESQTKP---------------- ----------APTELQTLILKPVTSPSLEMTQSQLVSEVLESVTFSTESSKETI------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------WQTPRAPP---------------------- --------KPKTSPH------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKGP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRATSKPKMS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEALYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDALL-PHKPD----PEV-----SQHESV------------LQPVT FRIEPPETT------------------------------------------IVP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPIISPSP- --SQEELQTTL------------------------------------------------- ------------------EETDQTTQELITTKIPRTTEWAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPV-------------------- ------------------RPRIPG------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NR---------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------IRPKPSGIPS----------------RNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------TKQAPK------------------------------------------- -------------------------------------------------------PSGA- --------------GRNVSVDF-------------------------------------- ---------------T-HS----------------------------T------------ ----KK-------P---------------------------------------------- ------------APIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RHPAG---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RS--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SIGI-------------------------------------------- -----ISSGRVTSPPLRATP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPTGIPS-E----------- --------R---PEIDK-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LGNTTDFSSSPTRETDHLGKPRFKGPHVRY-IPK PDNRPCSITDSVKRFPT-EEA-MEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQVTNQTFSTIENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQITYVQWYECGTTIPG KW >ENSMPUP00000011439 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLFCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP SLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNLSPNQYFPLPAEGKFTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RYYTIRYR--EKDKEKK-WVFQLCPATETIVENLKPNTVYEFGVKDNGEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITVIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTSF GGTILVHLIIPGLNETT-VKLPT-SIML-----------EISDAIKTQLAKNETLALPAE SKTPDVEKIPAR---------------------------------------AI------- --------TV-------------------------------------------------- ---TPESMPK---------TTKPTVSSALDFSEKTL-VLSERTPEILQTILIPRFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPQS----------------------------------------- ------------------------------------------------------------ ---------------------------NTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPEGTLAS-SGKPW----------- -IVPTSKTSEDSKLLS------------PRT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPATSDEPEM SESH-TATSDPFLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMPPTTP---------- -----------------------AAQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRV---------------------------RPKT--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEPQ---------------TLPLSQSTLA-------------------------- P----------------------------------------------------------- ------------PKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPD------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------VLEPA-------------------TVPPEPLVPTIASKPS------KRPK TT---------------------------------------------------------- -------RRPDA------------------------------------------------ -LQIQ------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQAPHAPP---------------------- --------KPKTSPH------PRIP----------------------------------- --------------QTHP---------------------------------A-------- ---HEVS----------------------------------------------------- ------------------------------------------------------------ ----------------------QPITSKPKAS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT LP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPRDVLL-PPKPD----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGSPFIPMISPST- --GEEELQTTL------------------------------------------------- ------------------EETDHSTQKFFTTKIPLTTELV-TTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPV-------------------- ------------------RPRIPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KTH IRPIL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------SRLKPSKTPK----------------GNGMG T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPK------------------------------------------- -------------------------------------------------------PSGA- --------------GKNVSMDS-------------------------------------- ---------------T-HS----------------------------T------------ ----KK-------P---------------------------------------------- ------------AAVP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPHL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------STGI-------------------------------------------- -----ILSGRVTSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------GPTEAPS-E----------- --------R---TETDE-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GED---LVNITDFSSSPTRETDPLGKPRFKGPHVRY-IQK PENRPCSITDSVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWDKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNE SVQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPPSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSFCAP00000048661 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNLSPNQYFPLPAEGKHTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKARSRKPLQLVVGTLSPSSVFLSWGFLINPHHD-WTLP SHCPND-RYYTIRYR--EKDKEKK-WVFQLCPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKS------------------------- ----------------------KVNGKIQSTYDQAHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITVIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTPF GGTILVHLIIPGLNETT-VKLPT-SIML-----------EISDAIKTQLAKNETLALPAE SKTPEVEKIPAR---------------------------------------PV------- --------TV-------------------------------------------------- ---TPESVPR---------TTKPTVSSALDFSEKTL-VLSERTPETPQTILIPRFELSLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPQA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTLAS-IEKPW----------- -IVPTSKIYEDSKPLP------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPDI SEPH-TETSDPFLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMPPTTP---------- -----------------------ATQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRV---------------------------RPKK--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSPGIITSKIPKSPEPTWTTLAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLIPEAIDTK--------------------- ---PAPEPQ---------------TLPPSQSTIG-------------------------- PETPE-----------TKP----------------------------------------- -----STTLA-SPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPD------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TVQPELLVPTVASKPS------KRPK TT---------------------------------------------------------- -------HRPDA------------------------------------------------ -PQIQP----------DSKPP----------------------KQLLP-KPQTT------ -----------AQPD--------------MPPTK---------PVFDPATFETEAPSTTI VPATDLEPVTLSTEAPRTTLA--------------------------------------- ----------------PKTTQRTRTR--R----------------PRPK-HKTTQSPAV- --SQTKLDSEPVTPGTSIA--------------TTTKRP-------------RRPRPKTK TTPHPE-------VPQTKL----------------------------VPTTVFE------ ---------------PVFLRTEAPGTTLAPKVP--------------------HET---- --------------------------------HPPHPKLKTTRSPEALDTELVPAIIFEP VTPMKETPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------VRTETSGTTLA-TKMS QRPRRPRPRP--K-TTPSSQVPQTKSVPATVLEPVMLIS-------------VIT----- ------------------------------------------------------------ ---------------------------------------------SKTSQQTRRPRPRPK TTPSLEVSQSKPVPTS-------------------------------------------- ------------------------------------------------------------ ---------------------------------DLEPVTLRTETWVTTQAPKTSKRTRRP RPKHKTTPT-------------------------------------------T------- -------------EVPQTKLVPTTDLEAGTLRTKAPEIVVLPTALEPVTLRTKDPE-TTL APKTAQRTR-------------RPRP--RPKTT-SSPEAPQTKRVPATSF------EPVI HSSEAPESTLAPTELQTLTLKPVTSPSLEKTQSQPVSEVLEFVTLSIESSKEAIAPTVTD YLYPSAKAPLSPEEPKTA-VVESITNVSEP-------------PET---TLETSPLPFQT IILP----------SPDEPPTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQIPRASP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------A-------- ---RKVP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTSKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT PP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VLRDVVL-PPKPD----PEV-----SQREP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGSPFIPMISPST- --SQEELQSTL------------------------------------------------- ------------------AETEQSTQEFFTTKIPPTTELTRTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPV-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KAH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------SRLKPSGTPK----------------GNGMG A------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPK------------------------------------------- -------------------------------------------------------PSGA- --------------GKDVSVDS-------------------------------------- ---------------T-HI----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RLPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGRVTSPPLTATF---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTEAPS-E----------- --------K---TETDE-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GED---LGNVTDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNRPCSITDSVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SVQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSPTIP00000010539 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP SLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNLSPNQYFPLPAEGKHTEAMV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLSPSSVFLSWGFLINPHHD-WTLP SHCPND-RYYTIRYR--EKDKEKK-WVFQLCPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKS------------------------- ----------------------KVNGKIQSTYDQAHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITVIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTPF GGTILVHLIIPGLNETT-VKLPT-SIML-----------EISDAIKAQLAKNETLALPAE SKTPEVEKIPAR---------------------------------------PI------- --------TV-------------------------------------------------- ---TPESVPR---------TTKPTVSSALDFSEKTL-VLSERTPETLQTVLIPRFELSLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKSLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPQA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTLAS-IEKPW----------- -IVPTSKIYEDSKPLP------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPDI SEPH-TETSDPFLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMPPTTP---------- -----------------------ATQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRV---------------------------RPKK--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSPGTITSKIPKSPEPTWTTLAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLIPEVIDTK--------------------- ---PAPEPQ---------------TLPPSQSTIG-------------------------- PETPE-----------TKP----------------------------------------- -----STTLA-SPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPD------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TVQPELLVPTVASKPS------KRPK TT---------------------------------------------------------- -------HRPDA------------------------------------------------ -PQIQP----------DSKPP----------------------KQLLP-KPQTT------ -----------AQPD--------------MPPTK---------PVFDPATFETEAPSTTI VPATDLEPVTLRTEAPRTTLA--------------------------------------- ----------------PKTTQRTRTR--R----------------PRPK-HKTTQSPAV- --SQTKLDSEPITPGTSIA--------------TTTKRP-------------RRPRPKTK TTPHPE-------VPQTKL----------------------------VPTTVSE------ ---------------PVFLRTEAPGTTLAPKVP--------------------HQT---- --------------------------------HPPHPKLKTTRSPEALDTELVPAIIFEP VTPMKETPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------VRTETSGTTLA-TKMS QRPRRPRPRP--K-TTPSSQVPQTKSVPATVLEPIMLIS-------------VIT----- ------------------------------------------------------------ ---------------------------------------------SKTSQQTRRPRPRPK TTPSLEVSQSKPVPTS-------------------------------------------- ------------------------------------------------------------ ---------------------------------DLEPVTLRTETWVTTQAPKTSKRTRRP RPKHKTTPT-------------------------------------------T------- -------------EVPQTKLVPTTDLEAGTLRTKAPEIVVLPTALEPVTLRTKDPE-TTL APKTAQRTR-------------RPRP--RPKTT-SSPEAPQTKRVPATSF------EPVI HSSEAPESTLAPTELQTLTLKPVTSPSLEMTQSQPVSEVPEFITLSIESSKEAIAPTVTD YLYPSAKAPLSPEEPKTA-VVESITNVSEP-------------PET---TLETSPLPFQT IILP----------SPDEPPTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQIPRASP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------A-------- ---RKVP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTSKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT PP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPRDVVL-PPKPD----PEV-----SQREP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGSPFIPMISPST- --SQEELRSTL------------------------------------------------- ------------------AEIEQSTQEFFTTKIPPTTELTRTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPV-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KAH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------SRLKPSGTPK----------------GNGMG A------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQTPK------------------------------------------- -------------------------------------------------------PSGA- --------------GKDVSVDS-------------------------------------- ---------------T-HI----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGRVTSPPLTATF---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTEAPS-E----------- --------K---TETDE-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GED---LGNVTDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNRPCSITDSVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWDKPLN DTVT-E------------------------------------YEVIS-RENGTFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSPPRP00000009876 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP SLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNLSPNQYFPLPAEGKHTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKARSRKPLQLVVGTLSPSSVFLSWGFLINPHHD-WTLP SHCPND-RYYTIRYR--EKDKEKK-WVFQLCPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKS------------------------- ----------------------KVNGKIQSTYDQAHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITVIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTPF GGTILVHLIIPGLNETT-VKLPT-SIML-----------EISDAIKAQLAKNETLALPAE SKTPEVEKIPAR---------------------------------------PI------- --------TV-------------------------------------------------- ---TPESVPR---------TTKPTVSSALDFSEK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------TLAS-IEKPW----------- -IVPTSKIYEDSKPLP------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPDI SEPH-TETSDPFLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMPPTTP---------- -----------------------ATQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRV---------------------------RPKK--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSPGTITSKIPKSPEPTWTTLAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLIPEAIDTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQIPRASP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------A-------- ---RKVP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTSKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT PP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPRDVVL-PPKPD----PEV-----SQREP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGSPFIPMISPST- --SQEELRSTL------------------------------------------------- ------------------AEIEQSTQEFFTTKIPPTTELTRTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPV-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KAH IRP--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQTPK------------------------------------------- -------------------------------------------------------PSGA- --------------GKDVSVDS-------------------------------------- ---------------T-HI----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGRVTSPPLTATF---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTEAPS-E----------- --------K---TETDE-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GED---LGNVTDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNRPCSITDSVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWDKPLN DTVT-E------------------------------------YEVIS-RENGTFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSBIXP00005014112 V-GGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSIFLKFLRPSPNVKLEGFLLGYGSNLSPNQYFPLPAEGKYTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKKRARKPLQLVVGTLSPSSVFLSWGFLINPHHD-WTLP SQCPND-RYYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPDTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKS------------------------- ----------------------KVNGKIQSTYDQVHSV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPVTIIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTPY GGTILVHLVIPGLNETT-VKLPT-SIMF-----------EISEAIKTQLAKNETLALPAE SKTPEVEKIPAL---------------------------------------PI------- --------TV-------------------------------------------------- ---TPESVPR---------TTKPTVSSALDISET-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------TLAS-SEKPG----------- -IVPTSKISEDSKILL------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SEPH-TATSDLLLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFIS--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTP---------- -----------------------APLQ--------------------------------- ------------------------------------------------------------ --TTSVPST--------------------------------------------------- ---PKRRL---------------------------RPKT--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------A--------------------------------------------------- --------------ER-TTSPGTVTSKISKSPEPRRTTMAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKVPLSPEVTDSK--------------------- ---P-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------S------------------------------------------------- ------------------------------KQIPRTPP---------------------- --------KPKTSPH------PRIP----------------------------------- --------------QTQS---------------------------------A-------- ---PKVF----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTLKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT PP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPRDVLL-PHKPD----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGSPLIPMISPST- --SQEELQTTL------------------------------------------------- ------------------AATEQSTQELFTTKVPQTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTTM-------------------- ------------------RPRTPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRP--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQVPL------------------------------------------- -------------------------------------------------------PSGT- --------------GRNVSMDS-------------------------------------- ---------------S-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------MPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSDRVTSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------IPTEAPL-E----------- --------R---METDK-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GED---LDNITDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNSPCSITDSVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWDKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQTTNQTFSTVENLKPDTSYEFQVKPINPLGEGPPSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSBBBP00000013395 V-GGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSIFLKFLRPSPNVKLEGFLLGYGSNLSPNQYFPLPAEGKYTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKKRARKPLQLVVGTLSPSSVFLSWGFLINPHHD-WTLP SQCPND-RYYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPDTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKS------------------------- ----------------------KVNGKIQSTYDQVHSV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPVTIIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTPY GGTILVHLVIPGLNETT-VKLPT-SIMF-----------EISEAIKTQLAKNETLALPAE SKTPEVEKIPAL---------------------------------------PI------- --------TV-------------------------------------------------- ---TPESVPR---------TTKPTVSSALDISET-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------TLAS-SEKPG----------- -IVPTSKISEDSKILL------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SEPH-TATSDLLLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFIS--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTP---------- -----------------------APLQ--------------------------------- ------------------------------------------------------------ --TTSVPST--------------------------------------------------- ---PKRRL---------------------------RPKT--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------A--------------------------------------------------- --------------ER-TTSPGTITSKISKSPEPRRTTMAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKVPLSPEVTDSK--------------------- ---P-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------S------------------------------------------------- ------------------------------KQIPRTPP---------------------- --------KPKTSPH------PRIP----------------------------------- --------------QTQS---------------------------------A-------- ---PKVF----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTLKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT PP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPRDVLL-PHKPD----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGSPLIPMISPST- --SQEELQTTL------------------------------------------------- ------------------AATDQSTQELFTTKVPQTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTTM-------------------- ------------------RPRTPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRP--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQVPL------------------------------------------- -------------------------------------------------------PSGT- --------------GRNVSMDS-------------------------------------- ---------------S-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------MPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSDRVTSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------IPTEAPL-E----------- --------R---METDK-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GED---LDNITDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNSPCSITDSVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWDKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQTTNQTFSTVENLKPDTSYEFQVKPINPLGEGPPSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSBMUP00000012951 V-GGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSIFLKFLRPSPDVKLEGFLLGYGSNLSPNQYFPLPAEGKYTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKKRARKPLQLVVGTLSPSSVFLSWGFLINPHHD-WTLP SQCPND-RYYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPDTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKS------------------------- ----------------------KVNGKIQSTYDQVHSV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPVTIIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTPY GGTILVHLVIPGLNETT-VKLPT-SIMF-----------EISEAIKTQLAKNETLALPAE SKTPEVEKIPAL---------------------------------------PI------- --------TV-------------------------------------------------- ---TPESVPR---------TTKPTVSSALDISET-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------TLAS-SEKPG----------- -IVPTSKISEDSKILL------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SEPH-TATSDLLLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFIS--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTP---------- -----------------------APLQ--------------------------------- ------------------------------------------------------------ --TTSVPST--------------------------------------------------- ---PKRRL---------------------------RPKT--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSPGTITSKISKSPEPRRTTMAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKVPLSPEVTDSK--------------------- ---P-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------S------------------------------------------------- ------------------------------KQIPRTPP---------------------- --------KPKTSPH------PRIP----------------------------------- --------------QTQS---------------------------------A-------- ---PKVF----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTLKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT PP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VARDVLL-PHKPD----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGSPLIPMISPST- --SQEELQTTL------------------------------------------------- ------------------AATDQSTQELFTTKVPQTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTTM-------------------- ------------------RPRTPE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRP--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQVPL------------------------------------------- -------------------------------------------------------PSGT- --------------GRNVSMDS-------------------------------------- ---------------S-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------MPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSDRVTSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------IPTEAPL-E----------- --------R---METDK-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GED---LDNITDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNSPCSITDSVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWDKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQTTNQTFSTVENLKPDTSYEFQVKPINPLGEGPPSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSOARP00000019535 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------WGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGFLLGYGSNLSPNQYFPLPAEGKYTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKKRPRKPLQLVVGTLSPSSVFLSWGFLINPHHD-WTLP SQCPND-RYYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPDTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKS------------------------- ----------------------KVNGKIQSTYDQVHSV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPVTIIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTPY GGTIVVHLVIPGLNETT-VKLPT-SIMF-----------EISEAIKTQLAKNETLALPAE SKTPEVEKIPAL---------------------------------------PI------- --------TV-------------------------------------------------- ---TPESVPR---------TTKPTVSSTLDISETTL-VLRGRTPGTSQTILIPRFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPQA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTLAS-REKPG----------- -IVPTSKISEDSKILP------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SEPH-TATSDPLLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFIS--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQSTTS---------- -----------------------APLQ--------------------------------- ------------------------------------------------------------ --TTSVPST--------------------------------------------------- ---PKRRL---------------------------RPKT--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSPGTITPKISKSPEPRRTTMAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTDSK--------------------- ---PAPEPE---------------ILLPSQ------------------------------ ------------------PP--------IVLEPGTLETK--------------------- --SS-TTTLA-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------RR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPH------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------VVPPEPLVPTI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------DSKPA----------------------KHLLS-KP--T------ -----------AKPD--------------TPPPT---------SVFEPVTSETEATLTSI VPATDIEPVTLRTEAPRTTLA--------------------------------------- ----------------PKTSQKTRKRRPR----------------PRPK-HKTTPRPET- --PQTKLDFEPITPGTSLAP------------TTTTKRP-------------RVPRPKPK TTPHPE-------APQTKL----------------------------VPATIPE------ ---------------PVSLRTEAPGTI--------------------------------- ---------------------------------------------------VVPAIVFEP VTPIKEAPETAFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FTTETSGTTLATTKTS QRPRRPRPRP--K-TTRGPQVPQTKLVPATMLEPV-------------------TLRTEA PGT--------------------------------------------------------- ------------------------------------------TLASKTSQQTIHPHPRPK TTPSAEAPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------DFEPVTFRTDAWVTTKAPKTSKRTRRP RPKLKTTTT-------------------------------------------P------- -------------EAPQTKPVPTTDLEPGTLRTEAPEIVVLPTVIEPVTHTTKAPE-TTL AYKTT-RVR-------------RPRP--RPKTT-SSPEAPQTK----------------- ---------LAPTELQTLILKPVTSPSLEMTQSQPVSEVLESLTFSTESSKEAIAPTEID YVYSTAKAPLRPEEPETE-VVESITHVSEP-------------PET---TL--------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------S------------------------------------------------- ------------------------------KQIPRTPP---------------------- --------KPKTSPH------PRIP----------------------------------- --------------QTQS---------------------------------A-------- ---PKVF----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTLKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT SP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPRDVLL-PHKPD----PEV-----SQSEPV------------LQPVT FRIHLPETT------------------------------------------LAP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGSPLIPMISPST- --SQEELQTTL------------------------------------------------- -------------------ETDQSTQELYTTKIPRMTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RVYTTTM-------------------- ------------------RPRTPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH LRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------SRPRPSGTPR----------------GNGIG A------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQVPL------------------------------------------- -------------------------------------------------------PSGT- --------------GRNISMDS-------------------------------------- ---------------S-HP----------------------------T------------ ----KK-------P---------------------------------------------- ------------AIIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------MPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSDRVTSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTEAPL-E----------- --------R---METDK-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GED---LDNMTDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNSPCSITDSVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWDKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQTTNQTFSTVENLKPDTSYEFQVKPKNPLGEGPPSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSECAP00000036053 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KP NLKVHINTTSDSIFLKFLRPNPNVKLEGFLLGYGSNLSPNQYFPLPAEGRHTEAVV--DA EPKYLIVVRPAPPPNRKKSCSGKARSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SQCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPDTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SK-------------------------- ----------------------KVNGKIQSTYDQAHSV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PSYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPVTIIKQ------------------------ -----------------------------------------VIQNVTHRASAKSPDKTPY GGTILVHLVIPGLNETT-VKLPT-SIMF-----------EISDALKTQLAKNETLALPAE SKTPEVEKIPAQ---------------------------------------PI------- --------TV-------------------------------------------------- ---TPESVPR---------TTKPTVPSALDISETTL-VLSERTPEASQTSLIPRFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKSIP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------ELPQA----------------------------------------- ------------------------------------------------------------ ---------------------------KTS------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KAGGTLAS-SEKPW----------- -IVPTTKTSEDSKVLP------------PRT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPATSDAPEL SEPH-TATSDPFLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTP---------- -----------------------APLQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRL---------------------------RPKT--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSPGTIASKVSKSFEPTRTTLAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPVSPEVTHTR--------------------- ---PAPKPQ---------------TLPPSQSALG-------------------------- PGTLA-----------TKP----------------------------------------- ---S-TTTLA-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPD------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TVPPEFLVPTIVSKPP------KRPK TT---------------------------------------------------------- -------YRPDA------------------------------------------------ -PQIQP----------DSKPP----------------------KQLFP-KHQTA------ -----------AKPD--------------MPPTK---------SVFEPVTSETETPSITI VAATDIDLVTVRTEAPRTTLA--------------------------------------- ----------------PKTPQRTRTR--R----------------PRPK-PKTTPRPEA- --PQTKPDVEPVTPGTSLAP------------AKTTKRP-------------RRPRPKPK TTPHPE-------VPQAKL----------------------------VPATVLE------ ---------------PGVLRTEAPETTLAPKEP--------------------PRT---- --------------------------------RRPRPKPKTTASPEAAQPDLVPATVFEP VTPVREAPGAAFV---------------------------------------P------- -------------------VTDF------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FAAETSGPTLA-PKAS QRPRRPRPRP--K-TTPSPQAPQTKLVPAIILEPV-------------------TLRPEA SGA--------------------------------------------------------- ------------------------------------------TLASKTSQQTSRPHPRPK TTPSPEVPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------GFEPVTFRTEAWVTTQAPKTSKRTRRP RPKPKTTPT-------------------------------------------T------- -------------KAPQTTPVPTTDLEPGTVRTEAPEIVVLPTVLEPVTLRTKAPE-TTF APKTSQRAR-------------RPRP--RPKTT-SSPAAPQTKPVPTTGF------APVV HSSEAPGTTLAPTELQPLILKPVTSPSLEMTQSQPVSEVLESVTFSTESSMEAIAPAETD YVYPTAKAPLRPEEPKAE-VVESVTNVSEP-------------PET---SLETSPLPSQT ITLP----------SPDEPRTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPP---------------------- --------KPKTSAH------PRVP----------------------------------- --------------QTQP---------------------------------A-------- ---PKVS----------------------------------------------------- ------------------------------------------------------------ ----------------------QHVTSKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSHT PA---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPRDVLL-PHKPA----PEG-----SQSEP------------------ ----------------------------------------------------GP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGSPFIPMISPSP- --SQEELLTAL------------------------------------------------- ------------------AETDQTTQEVFTTKISRTTELAKTTP---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPG-------------------- ------------------RPRTPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPR SRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------SRPKPSRMPT----------------GDGMG -------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQPPK------------------------------------------- -------------------------------------------------------PSGA- --------------GRDVLVDS-------------------------------------- ---------------T-HA----------------------------T------------ ----KR------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSSRVTSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTEAPL-E----------- --------G---TETDK-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GED---LGNTTDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNRPCSITDSVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWDKPLN DTVT-E------------------------------------YEVIS-RENGTFSG-KNK SVQVTNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLDSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSCSAP00000002397 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MF------------------------------------------------- -----SFP------------------------------LLG------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKDSTKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLMF-----------EISDALKTQLAKNETLALPAK SKTPEVEKISAR---------------------------------------ST------- --------TE-------------------------------------------------- ---TPETVPR---------TTKPTTSSALDVSETTLVVVSKRTPETLQTVLIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTWAS-SEKPW----------- -TVPTAKTSEDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTA---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------PA-------------------------------------------------- --------------ER-TTSAGTITPKISKSPEPTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKISLSPEVTHTK--------------------- ---PVPEPQ---------------TLLPSQSTIG-------------------------- PETLE-----------TKP----------------------------------------- ---S-TTTLA-PRKTK---------------------------------------RPGR- -RP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TIPPEPLVPTTASKPS------ERPK TT---------------------------------------------------------- -------PRPDA------------------------------------------------ -PQIQP----------GSKPP----------------------KQLLP-KPQTT------ -----------AEPD--------------MPPTK---------SISEPVAFETEAPSMTI VPTTDIKPVTVRTEAPVTTLA--------------------------------------- ----------------PKTSQRTRTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPITPGTSSAP-------------TTTKRT-------------RRPHPKPK TTPHPE-------VPQTKL----------------------------VPATILE------ ---------------PV-LRTEAPGTTVAPKVP--------------------QRT---- --------------------------------RRPHPKPKTTPSPEELQTELVPATIFEP VSPIKEVPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTETPATTLA-TKTS KRTRPPRPRP--K-TTPSPQAPETKPVPATVLEPV-------------------TLRPEA S-T--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRLRTK TTPHPEVPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELKPVTLRTETWVTTQAPKTSQRTRRP RPKTKTTPS-------------------------------------------P------- -------------EVPQTKPVPVTDLEPGTLRTEAPKTMVVSTVLEPDTFRTKIPE-TTL APKT-QRTR-------------RPRP--RPKTT-SSPEVPQNKSVSVTGF------EPVV HSTDAPGTTFAPTDLQTLILKPVTSPSLEMTESRPVSDVLESVTFSTESPKETIAPAKTD YVYPTAKAPLWPEEPKTE-VVESVTYVSEP-------------PET---TLETSPLPSQS ITLP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRALP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKGP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTAKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PHKPD----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTIL------------------------------------------------- ------------------EEADQSTQERFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTT-V-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPK------------------------------------------- -------------------------------------------------------PSGA- --------------DRNVSVDS-------------------------------------- ---------------P-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGPITIPPLRSTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPL-E----------- --------R---IATDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---MENITDFSSSPTRETDPLGKPRFKGPHVRY-LQK PDDSPCSITDSVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFD-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSMMUP00000069505 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MF------------------------------------------------- -----SFP------------------------------LLG------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHAV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKDSTKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLMF-----------EISDALKTQLAKNETLALPAK SKTPEVEKISAR---------------------------------------ST------- --------TE-------------------------------------------------- ---TPETVPR---------TTKPTTSSALDVSETTL-VVSKRTPETLQTVLIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTWAS-SEKPW----------- -IVPTAKISEDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTA---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITPKISKSPEPTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTHTK--------------------- ---PVPEPQ---------------TLLPSQSTIG-------------------------- PETLE-----------TKP----------------------------------------- ---STTTTLA-PRKTK---------------------------------------RPGR- -RP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TIQPEPLVPTTASKPS------ERPK TT---------------------------------------------------------- -------PRPDA------------------------------------------------ -PQIQP----------GSKPP----------------------KQLLP-KPQTT------ -----------AEPD--------------MPPTK---------SVSEPVAFETEAPSMTI VPTTDIEPVTVRTEAPVTTLA--------------------------------------- ----------------PKTSQRTRTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPITPGTSSAP-------------TTTKRT-------------RRPHPKPK TTPHPE-------VPQTKL----------------------------VPATILE------ ---------------PV-LRTEAPGTTVAPKVP--------------------QRT---- --------------------------------RRPHPKPKTTPSPEELQTELVPATIFEP VSPIKEAPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTETPATTLA-TKTS KRTRPPRPRP--K-TTPSPQAPETKPVPATVLEPV-------------------TLRPEA S-T--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRLRTK TTPRPEVPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELKPVTLRTETWVTTQAPKTSQRTRRP RPKTKTTPS-------------------------------------------P------- -------------EVPQTKPVPVTDLEPGTLRTEAPKTMVVTTVLEPDTFRTKVPE-TTL APKT-QRTR-------------RPRP--RPKTT-SSPEVPQNKSVSFTGF------EPVV HRTDAPGTTFAPTDLQTLILKPVTSPSLEMTESQPVSDVLESVTFSTESPKETIAPAKTD YVYPTAKAPLWPEEPKTE-VVESVTYVSEP-------------PET---TLETSPLPSQS ITLP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRALP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKGP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRITAKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PHKPD----PEV-----SQSEPV------------LQPVT FRFEPPKTT------------------------------------------IAP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTIL------------------------------------------------- ------------------EETDQSTQERFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTT-V-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------HRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPK------------------------------------------- -------------------------------------------------------PSGA- --------------DRNVSVDS-------------------------------------- ---------------P-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSSPITIPPLRSTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPL-E----------- --------R---IATDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-LQK PDDSPCSITDSVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFD-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSMNEP00000033340 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHAV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKDSTKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLMF-----------EISDALKTQLAKNETLALPAK SKTPEVEKISAR---------------------------------------ST------- --------TE-------------------------------------------------- ---TPETVPR---------TTKPTTSSALDVSETTL-VVSKRTPETLQTVLIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTWAS-SEKPW----------- -IVPTAKISEDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTA---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITPKISKSPEPTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTHTK--------------------- ---PVPEPQ---------------TLLPSQSTIG-------------------------- PETLE-----------TKP----------------------------------------- ---STTTTLA-PRKTK---------------------------------------RPGR- -RP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TIQPEPLVPTTASKPS------ERPK TT---------------------------------------------------------- -------PRPDA------------------------------------------------ -PQIQP----------GSKPP----------------------KQLLP-KPQTT------ -----------AEPD--------------MPPTK---------SVSEPVAFETEAPSMTI VPTTDIEPVTVRTEAPVTTLA--------------------------------------- ----------------PKTSQRTRTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPITPGTSSAP-------------TTTKRT-------------RRPHPKPK TTPHPE-------VPQTKL----------------------------VPATILE------ ---------------PV-LRTEAPGTTVAPKVP--------------------QRT---- --------------------------------RRPHPKPKTTPSPEELQTELVPATIFEP VSPIKEAPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTETPATTLA-TKTS KRTRPPRPRP--K-TTPSPQAPETKPVPATVLEPV-------------------TLRPEA S-T--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRLRTK TTPRPEVPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELRPVTLRTETWVTTQAPKTSQRTRRP RPKTKTTPS-------------------------------------------P------- -------------EVPQTKPVPVTDLEPGILRTEAPKTMVVTTVLEPDTFRTKVPE-TTL APKT-QRTR-------------RPRP--RPKTT-SSPEVPQNKSVSFTGF------EPVV HRTDAPGTTFAPTDLQTLILKPVTSPSLEMTESQPVSDVLESVTFSTESPKETIAPAKTD YVYPTAKAPLWPEEPKTE-VVESVTYVSEP-------------PET---TLETSPLPSQS ITLP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRALP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKGP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRITAKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PHKPD----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTIL------------------------------------------------- ------------------EETDQSTQERFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTT-V-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------HRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPK------------------------------------------- -------------------------------------------------------PSGA- --------------DRNVSVDS-------------------------------------- ---------------P-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSSPITIPPLRSTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPL-E----------- --------R---IATDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-LQK PDDSPCSITDSVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFD-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSMFAP00000023241 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHAV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKDSTKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLMF-----------EISDALKTQLAKNETLALPAK SKTPEVEKISAR---------------------------------------ST------- --------TE-------------------------------------------------- ---TPETVPR---------TTKPTTSSALDVSETTL-VVSKRTPETLQTVLIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTWAS-SEKPW----------- -IVPTAKISEDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTA---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITPKISKSPEPTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTHTK--------------------- ---PVPEPQ---------------TLLPSQSTIG-------------------------- PETLE-----------TKP----------------------------------------- ---STTTTLA-PRKTK---------------------------------------RPGR- -RP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TIQPEPLVPTTASKPS------ERPK TT---------------------------------------------------------- -------PRPDA------------------------------------------------ -PQIQP----------GSKPP----------------------KQLLP-KPQTT------ -----------AEPD--------------MPPTK---------SVSEPVAFETEAPSMTI VPTTDIEPVTVRTEAPVTTLA--------------------------------------- ----------------PKTSQRTRTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPITPGTSSAP-------------TTTKRT-------------RRPHPKPK TTPHPE-------VPQTKL----------------------------VPATILE------ ---------------PV-LRTEAPGTTVAPKVP--------------------QRT---- --------------------------------RRPHPKPKTTPSPEELQTELVPATIFEP VSPIKEAPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTETPATTLA-TKTS KRTRPPRPRP--K-TTPSPQAPETKPVPATVLEPV-------------------TLRPEA S-T--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRLRTK TTPRPEVPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELKPVTLRTETWVTTQAPKTSQRTRRP RPKTKTTPS-------------------------------------------P------- -------------EVPQTKPVPVTDLEPGTLRTEAPKTMVVTTVLEPDTFRTKVPE-TTL APKT-QRTR-------------RPRP--RPKTT-SSPEVPQNKSVSFTGF------EPVV HRTDAPGTTFAPTDLQTLILKPVTSPSLEITESQPVSDVLESVTFSTESPKETIAPAKTD YVYPTAKAPLWPEEPKTE-VVESVTYVSEP-------------PET---TLETSPLPSQS ITLP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRALP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKGP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRITAKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PHKPD----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTIL------------------------------------------------- ------------------EETDQSTQERFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTT-V-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------HRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPK------------------------------------------- -------------------------------------------------------PSGA- --------------DRNVSVDS-------------------------------------- ---------------P-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSSPITIPPLRSTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPL-E----------- --------R---IATDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-LQK PDDSPCSITDSVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-KENGSFSG-KNK SIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFD-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSPANP00000002027 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKDSTKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLMF-----------EISDALKTQLAKNETLALPAK SKTPEVEKISAR---------------------------------------ST------- --------TE-------------------------------------------------- ---TPETVPR---------TTKPTTSSALDVSGTTL-VVSKRTPETLQTILIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTLAS-SEKPW----------- -IVPTAKISEDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTA---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITPKISKSPEPTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTHTK--------------------- ---PVPEPQ---------------TLLPSQSTIG-------------------------- PETLE-----------TKP----------------------------------------- ---S-TTTLA-PRKTK---------------------------------------RPGR- -RP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TIQPEPLVPTTASKPS------ERPK TT---------------------------------------------------------- -------PRPDA------------------------------------------------ -PQIQP----------GSKPP----------------------KQLLP-KPQAT------ -----------AEPD--------------MPPTK---------SVSEPVAFETEAPSMTI VPTTDIEPVTVRTEAPVTTLA--------------------------------------- ----------------PKTSQRTRTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPITPGTSSAP-------------TTTKRT-------------RRPHPKPK TTPHPE-------VPQTKL----------------------------VPATILE------ ---------------PV-LRTEAPGTTVAPKVP--------------------QRT---- --------------------------------RRPHPKPKTTPSPEELQTELVPATIFEP VSPIKEAPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTETPATILA-TKTS KRTRPPRPRP--K-TTPSPQAPETKPVPATVLEPV-------------------TLRPEA S-T--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRLRTK TTPHPEVPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELKPVTLRTETWVTTQAPKTSQRTRRP RPKTKTTPS-------------------------------------------P------- -------------EVPQTKPVPVTDLEPGTLRTEAPKTMVVTTVLEPDTFRTKVPE-TTL APKT-QRTR-------------RPRP--RPKTT-SSPEVPQNKSVSVTGF------EPVV HRTDAPGTTFAPTDLQTLILKPVTSPSLEMTESQPVSDVLESVTLSTESPKETIAPAKTD YVYPTAKAPLWPEEPKTE-VVESVTYVSEP-------------PET---TLETSPLPSQS ITLP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKGP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRITAKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PHKPD----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTIL------------------------------------------------- ------------------EETDQSTQERFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTT-V-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------HRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPK------------------------------------------- -------------------------------------------------------PSGA- --------------DRNVSVDS-------------------------------------- ---------------P-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------HPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGPITIPPLRSTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPL-E----------- --------R---IATDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-LQK PDDSPCSITDSVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFD-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSTGEP00000031460 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKDSTKSPEKTPL GGVILVHLIIPGLNETT-VKLPA-SLMF-----------EISDALKTQLAKNETLALPAK SKTPEVEKISAR---------------------------------------ST------- --------TE-------------------------------------------------- ---TPETVPR---------TTKPTTSSALDVSGTTL-VVSKRTPETLQTILIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTLAS-SEKPW----------- -IVPTAKISEDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTA---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITPKISKSPEPTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTHTK--------------------- ---PVPEPQ---------------TLLPSQSTIG-------------------------- PETLE-----------TKP----------------------------------------- ---S-TTTLA-PRKTK---------------------------------------RPGR- -RP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TIQPEPLVPTTASKPS------ERPK TT---------------------------------------------------------- -------PRPDA------------------------------------------------ -PQIQP----------GSKPP----------------------KQLLP-KPQAT------ -----------AEPD--------------MPPTK---------SVSEPVAFETEAPSMTI VPTTDIEPVTVRTEAPVTTLA--------------------------------------- ----------------PKTSQRTRTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPITPGTSSAP-------------TTTKRT-------------RRPHPKPK TTPHPE-------VPQTKL----------------------------VPATILE------ ---------------PV-LRTEAPGTTVAPKVP--------------------QRT---- --------------------------------RRPHPKPKTTPSPEELQTELVPATIFEP VSPIKEAPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTETPATTLA-TKTS KRTRPPRPRP--K-TTPSPQAPETKPVPATVLEPV-------------------TLRPEA S-T--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRLRTK TTPRPEVPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELKPVTLRTETWVTTQAPKTSQRTRRP RPKTKTTPS-------------------------------------------P------- -------------EVPQTKPVPVTDLEPGTLRTEAPKTMVVTTVLEPDTFRTKVPE-TTL APKT-QRTR-------------RPRP--RPKTT-SSPEVPQNKSVSVTGF------EPVV HSTDATGTTFAPTDLQTLILKPVTSPSLEMTESQPVSDVLESVTFSTESPKETIAPAKTD YVYPTAKAPLWPEEPKTE-VVESVTYVSEP-------------PET---TLETSPLPSQS ITLP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKGP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRITAKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PHKPD----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTIL------------------------------------------------- ------------------EETDQSTQERFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTT-V-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------HRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPK------------------------------------------- -------------------------------------------------------PSGA- --------------DRNVSVDS-------------------------------------- ---------------P-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGPITIPPLRSTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPL-E----------- --------R---IATDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-LQK PDDSPCSITDSVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFD-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSCATP00000000742 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKDSTKSPEKAPF GGVILVHLIIPGLNETT-VKLPA-SLMF-----------EISDALKTQLAKNETLALPAK SKTPEVEKISAR---------------------------------------ST------- --------TE-------------------------------------------------- ---TPEAVPR---------TTKPTTSSALDVSGTTL-VVSKRTPETLQTILIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTLAS-SEKPW----------- -IVPTAKISEDSKVLQ------------PPT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTA---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITPKISKSPEPTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTHTK--------------------- ---PVPEPQ---------------TLLPSQSTIG-------------------------- PETLE-----------TKP----------------------------------------- ---S-TTTLA-PRKTK---------------------------------------RPGR- -RP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KIT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TIQPEPLVPTTASKPS------ERPK TT---------------------------------------------------------- -------PRPDA------------------------------------------------ -PQIQP----------GSKPP----------------------KQLLP-KPQTT------ -----------AEPD--------------MPPTK---------SVSEPVAFETEAPSMTI VPTTDIEPVTVRTEAPVTTLA--------------------------------------- ----------------PKTSQRTRTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPITPGTSSAP-------------TTTKRT-------------RRPHPKPK TTPHPE-------VPQTKL----------------------------VPATILE------ ---------------PV-LRTEAPGTTVAPKVP--------------------QRT---- --------------------------------RRPHPKPKTTPSPEELQTELVPATIFEP VSPIKEAPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTETPATTLA-TKTS KRTRPPRPRP--K-TTPSPQAPETKPVPATVLEPV-------------------TLRPEA S-T--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRLRTK TTPRPEVPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELKPVTLRTETWVTTQAPKTSQRTRRP RPKTKTTPS-------------------------------------------P------- -------------EVPQTKQVPVTDLEPGTLRTEAPKTMVVTTVLEPDTFRTKVPE-TTL APKT-QRTR-------------RPRP--RPKTT-SSPEVPQNKSVSVTGF------EPVV HRTDAPETTFAPTDLQTLILKPVTSPSLEMTESQPVSDVLESVTFSTESPKETIAPAKTD YVYPTAKAPLWPEEPKTE-VVESVTYVSEP-------------PET---TLETSPLPSQS ITLP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKGP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRITAKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PHKPD----LEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTIL------------------------------------------------- ------------------EETDQSTQERFTTKIPRTTEPAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTT-V-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------HRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQALK------------------------------------------- -------------------------------------------------------PSGA- --------------DRNVSVDS-------------------------------------- ---------------P-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGPITIPPLRSTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPL-E----------- --------R---IATDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-LQK PDDSPCSITDSVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFD-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSMLEP00000022825 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKDSTKSPEKAPL GGVI--------------------------------------------LAKNETLALPAK SKTPEVEKISAR---------------------------------------ST------- --------TE-------------------------------------------------- ---TPETVPR---------TTKPTTSSALDVSGTTL-VVSKRTPETLQTILIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTWAS-SEKPW----------- -IVPTAKISEDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTA---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITPKISKSPEPTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTHTK--------------------- ---PVPEPQ---------------TLLPSQSTIG-------------------------- PETLE-----------TKP----------------------------------------- ---S-TTTLA-PRKTK---------------------------------------RPGR- -RP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TIQPEPLVPTTASKPS------ERPK TT---------------------------------------------------------- -------PRPDA------------------------------------------------ -PQIQP----------GSKPP----------------------KQLLP-KPQTT------ -----------AEPD--------------MPPTK---------SVSEPVAFETEAPSMTI VPTTDIEPVTVRTEAPVTTLA--------------------------------------- ----------------PKTSQRTRTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPITPGTSSAP-------------TTTKRT-------------RRPHPKPK TTPHPE-------VPQTKL----------------------------VPATILE------ ---------------PV-LRTEAPGTTVAPKVP--------------------QRT---- --------------------------------RRPHPKPKTTLSPEELQTELVPATIFEP VSPIKEAPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTEIPATTLA-TKTT KRTRPPRPRP--K-TTPSPQAPETKPVPATVLEPV-------------------TLRPEA S-T--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRLRTK TTPRPEVPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELKPVTLRTETWVTTQAPKTSQRTRRP RPKTKTTPS-------------------------------------------P------- -------------EVPQTKQVPVADLEPGTLRTEAPKTMVVTTVLEPDTFRTKVPE-TTL APKT-QRTR-------------RPRP--RPKTT-SSPEVPQNKSVSVTGF------EPVV HRTDAPETTFAPTDLQTLILKPVTSPSLEMTESQPVSDVLESVTFSTESPKETIAPAKTD YVYPTAKAPLWPEEPKTE-VVESVTYVSEP-------------PET---TLETSPLPSQS ITLP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKGP----------------------------------------------------- ------------------------------------------------------------ ----------------------PHITAKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PHKPD----LEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTIL------------------------------------------------- ------------------EETDQSIQERFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTT-V-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------HRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPK------------------------------------------- -------------------------------------------------------PSGA- --------------DRNVSVDS-------------------------------------- ---------------P-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGPITIPPLRSTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPL-E----------- --------R---IATDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-LQK PDDSPCSITDSVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFD-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSPTEP00000029709 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKDSTKSSEKAPL GGVILVHLIIPGLNETT-VKLPA-SLMF-----------EISDALKTQLAKNETLALPAK SKTPEVEKISAR---------------------------------------ST------- --------TE-------------------------------------------------- ---TPETVPR---------TTKPTTSSALDVSETTL-VVSKRTPETLQTIVIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTLAS-SEKPW----------- -IVPTAKTSEDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPR-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEILTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------AMQPTTP---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --STSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITPKISKSPEPTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTHTK--------------------- ---PVPEPQ---------------TLLPSQSTIG-------------------------- PETLG-----------TKP----------------------------------------- ---S-TTTLA-PRKTK---------------------------------------RPGR- -RP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TIQPEPLVPTTASKPS------ERPK TT---------------------------------------------------------- -------PRPDA------------------------------------------------ -PQIQP----------GSKPP----------------------KQLLP-KPQTT------ -----------AEPD--------------MPPTK---------SVSEPVPFETEAPSMTI VPTTDTEPVTVRTEAPVTTLA--------------------------------------- ----------------PKTPQRTRTR--R----------------PRPK-HKTTPRPET- --TQTKLDFGPITPGTSSAP-------------TTTKRT-------------RRPHPKPK TTPHPE-------VPQTKL----------------------------VPATILE------ ---------------PV-LRTEAPGTTVAPKVP--------------------QRT---- --------------------------------RRPHPKPKTTLSPEELQTELVPATIFEP VSPIKEAPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------APVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTETPATTLA-TKTS KRTRPPRPRP--K-TTPSPQAPETKPVPATVLEPV-------------------TLRPEA S-T--------------------------------------------------------- ------------------------------------------TLASETSQRTRRPRLRTK TTPRPEVPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELKPVTLRTETWVTTQAPKTSQRTRRP RPKTKTTPS-------------------------------------------P------- -------------EVPQTKPVPVTDLEPGTLRTEAPKTMVVTTVLEPDTFRTKFPE-TTL APKT-QRTR-------------RPRP--RPKTT-SSPEVPQNKSVSVTGF------EPVV HSTDAPGTTFAPTDLQTLILKPVTSPSLEMTESQPVSDVLESVTFSTESPKKTIAPAKTD YVYPTAKAPLWPEEPKTE-VVESVTYVSEP-------------PET---TLETSPLPSQS ITLP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPS---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKGP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTAKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PHKPD----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTIL------------------------------------------------- ------------------EETDQSTQERFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTT-V-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPK------------------------------------------- -------------------------------------------------------PSGA- --------------DRNVSVDS-------------------------------------- ---------------P-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPLL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGPITVPPLRSTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPL-E----------- --------R---IATDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-LQK PDNSPCSITDSVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFD-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSPTRP00000075719 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKDSAKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLMF-----------EISDALKTQLAKNETLALPAE SKTPEVEKISAR---------------------------------------PT------- --------TV-------------------------------------------------- ---TPETVPR---------STKPTTSSALDVSETTL-VLSKRTPETLQTILIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKSLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPRGTLAS-SEKPW----------- -IVPTAKISEDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SIP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTP---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITPKISKSPEPTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTHTK--------------------- ---PAPEPQ---------------TLLPSQSTIG-------------------------- PETPG-----------TKP----------------------------------------- ---S--TTLA-PRKTK---------------------------------------RPGR- -RP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TIQPEPLVPTTASKPS------ERPK TT---------------------------------------------------------- -------HRPDA------------------------------------------------ -PQIQP----------GSKPP----------------------KQLLP-KPQTT------ -----------AEPD--------------MPPTK---------SVSEPVPFETEAPSMTI VPTTDIEPVTVRTEATVTTLA--------------------------------------- ----------------PKTSQRTRTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPITPGTSSAP------------TTTTKRT-------------RRPHPKPK TTPHPE-------VPQTKL----------------------------VPATILE------ ---------------PV-LRTEASGTTAAPKVP--------------------QRT---- --------------------------------RRPHPKPKTTLSPEELQTELVPATIFEP VSPIKEAPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTEIPATTLA-TKTS KRTRPPRPRP--K-TTPSPQAPETKPVPATVLEPV-------------------TLRPEA S-T--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRLRTK TTPRPEAPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELKPVTLRTETWVTTQAPKTSQRTRRP RPKTKTTPS-------------------------------------------P------- -------------EVPQTKLVPSTDLEPGTLRTEAPKTMVVTTVLEPDTFRTKFPE-TTL APKT-QRTR-------------RPRP--RPKTT-SSPEVPQNKSVSVTGF------EPVV HSTDAPGTTFAPTELQTLILKPVTSPSLEMTESQPVSDVLESVTFSTESPKETIAPAKTD YVYPTAKAPLWPEEPKTE-VVESITYVSEP-------------PET---TLETSPLPSQS ITLP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKVP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTAKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PHKPY----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTTL------------------------------------------------- ------------------EETDQSTQEPFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTT-V-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPR------------------------------------------- -------------------------------------------------------PSGA- --------------GRNVSADS-------------------------------------- ---------------T-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGPITIPPLRSTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPL-E----------- --------R---IVTDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNSPCSITDSVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQMTNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSP00000284322 MRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKDSAKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLMF-----------EISDALKTQLAKNETLALPAE SKTPEVEKISAR---------------------------------------PT------- --------TV-------------------------------------------------- ---TPETVPR---------STKPTTSSALDVSET-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------TLAS-SEKPW----------- -IVPTAKISEDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SDSY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SIP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTP---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITPKISKSPEPTWTTPAPG----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKVP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTAKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PHKPY----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTTL------------------------------------------------- ------------------EETDQSTQEPFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTT-V-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRP--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPR------------------------------------------- -------------------------------------------------------PSGA- --------------DRNVSVDS-------------------------------------- ---------------T-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------THPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGPITTPPLRSTP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPL-E----------- --------R---IETDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNSPCSITDSVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQMTNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSPPYP00000015200 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKDSTKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLMF-----------EISDALKTQLAKNETLALPAE SKTPEVEKISAR---------------------------------------PT------- --------TV-------------------------------------------------- ---TPETVPR---------STKPTTSSALGVSET-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------TLAS-SEKPW----------- -IVPTAKISEDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SIP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVQPTTP---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------PA-------------------------------------------------- --------------ER-TTSAGTITPKISKSPEPTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTHTK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKVP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRFTAKPKTL---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PLKPY----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTTL------------------------------------------------- ------------------EETDQSTQEPFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTT-V-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRP--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQVPR------------------------------------------- -------------------------------------------------------PSGV- --------------GRNISVDS-------------------------------------- ---------------T-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGPITIPPLRSTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPL-E----------- --------R---IATDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNSPCSITDSVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQMTNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSNLEP00000033498 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKDSTKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLMF-----------EISDALKTQLAKNETLALPAE SKTPEVEKISAR---------------------------------------PT------- --------TV-------------------------------------------------- ---TPETVPR---------STKPTTSSALDVSETTL-VLSKRTPETLQTLLIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPRGTLAS-SEKPW----------- -IVPTAKISEDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTP---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITPKISKSPEPTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSSEVTHTK--------------------- ---PAPEPQ---------------TLLPSQSTIG-------------------------- PETLG-----------TKP----------------------------------------- ---S-TTTLA-PGKTK---------------------------------------RPGRR PRP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TIQPEPLVPTTASKPS------ERPK TT---------------------------------------------------------- -------HRPDA------------------------------------------------ -PQIQP----------GLKPP----------------------KQLLP-KPQTT------ -----------AEPD--------------MPPTK---------SVSEPVPSETEAPLMAI VPTTDIEPVTVRTEAAATTLA--------------------------------------- ----------------PKTSQRTRTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPITPGTSSAP-------------TTTKRT-------------RRPHPKPK TTPHPE-------VPQTKL----------------------------VPATILE------ ---------------PV-LRTEAPGTTVAPKVP--------------------QRT---- --------------------------------RRPHPKPKTTLSPEELHTELVPATIFEP VSPIKEAPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTEIPATTLA-TKTS KRTRPPRPRP--K-TTLSPQAPETKPVPATVLEPV-------------------TVRPEA S-T--------------------------------------------------------- ------------------------------------------TLAAKTSQRTRRPRLRTK TTPRPEAPESKPVLTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELKPVTLRTETWVTTQAPKTSQRTRRP RPKTKTTPS-------------------------------------------P------- -------------EVPQTKLVPATDLEPGTLRTEAPKTMVVTTVLEPDTFRTKVPE-TTL APKT-QRTR-------------LPRP--RPKTT-SSPEVSQNKSVSVTGF------EPVV HSTDAPGTTFAPTELQTLILKPVTSPSLEMTESQPVSDVLESVTFSTESPKETIAPAKTD YVYPTAKAPLWPEEPKTE-VVETITYVSEP-------------PET---TLETSPLPSQS ITLP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKVP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTAKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PHKPD----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SREELQTTL------------------------------------------------- ------------------EETDQSTQEPFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTT-M-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------RNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPR------------------------------------------- -------------------------------------------------------PSGV- --------------GRNVSVDS-------------------------------------- ---------------T-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----LRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGPITIPPLRSTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPL-E----------- --------R---IATDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNSPCSITDSVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQMTNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSGGOP00000017727 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQGNFVC----------SGNV----- ----------------FREIFNILLAKVI----------KH------------------- -----VHLIIPGLNETT-VKLPA-SLMF-----------EISDALKTQLAKNETLALPAE SKTPEVEKISAR---------------------------------------PT------- --------TV-------------------------------------------------- ---TPETVPR---------STKPTTSSALDVSETTL-VLSKRTPETLQTILIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKSLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPRGTLAS-SEKPW----------- -IVPTTKISEDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SIP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTP---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITPKISKSPEPTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTHTK--------------------- ---P-------------------------------------------------------- ------------------------------------------------------------ ---------A-PRKTK---------------------------------------RPGR- -RP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TIQPEPLVPTTASKPS------ERPK TT---------------------------------------------------------- -------HRPDA------------------------------------------------ -PQIQP----------GSKPP----------------------KQLLP-KPQTT------ -----------AEPD--------------MPPTK---------SVSEPVPFETEAPSMTI VPTTDIEPVTVRTEATVTTLA--------------------------------------- ----------------PKTSQRTRTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPITPGTSSAP------------TTTTKRT-------------RRPHPKPK TTPHPE-------VPQTKLGKYVVSVFIILSTASGTKHALQTELGKFV------------ ------------------------------------------------------------ ----------------------------------------------------VPATIFEP VSPIKEAPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTEIPATTLA-TKTS KRTRPPRPRP--K-TTPSPQAPETKPVPATVLEPV-------------------TLRPEA S-T--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRLRKK TTPRPEAPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELKPVTLRTETWVTTQAPKTSQRTRRP RPKTKATPS-------------------------------------------P------- -------------EVPQTKLVPSTDLEPGTLRTEAPKTMVVTTVLEPDTFRTKFPE-TTL APKT-QRTR-------------RPRP--RPKTT-SSPEVPQNKSVSVTGF------EPVV HRTDAPGTTFAPTELQTLILKPVTSPSLEMTESQPVSDVLESVTFSTESPKETIAPAKTD YVYPTAKAPLWPEEPKTE-VVESITYVSEP-------------PET---TLETSPLPSQS ITLP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKVP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTAKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PHKPY----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTTLGK------------------------------------FCFNICSK--- ------------RCSSVS------------------------------------------ ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTT-V-------------------- ------------------RPRTSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPR------------------------------------------- -------------------------------------------------------PSGA- --------------GRNVSVDS-------------------------------------- ---------------T-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGPITIPPLRSTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPL-E----------- --------R---IVTDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNSPCSITDSVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQMTNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSANAP00000011327 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLVL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP SLKVHINTTSDSIFLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKARSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKASTKSPEKAPM GGVILVHLIIPGLNETT-VKLPA-SLMF-----------EISDALKTQLAKNETLALPAE SKTPEVEKIPAR---------------------------------------PT------- --------TV-------------------------------------------------- ---TPETVPR---------TAKPTMPSALDVSETTL-VLSKRTPETLQTILIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFSEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTLAS-SEKPW----------- -IVPTAKTSDDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPMTPEEPEI LESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFGP--------------------------- ------------------------------------------------------------ ---------------------------QNLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------ETQPTTP---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITPKISKSPESTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QSISLKPKIPLSPEVTHTK--------------------- ---PAPEPQ---------------TPLPSESTIG-------------------------- PETRG-----------TKP----------------------------------------- ---S-TTTLA-PRKTK---------------------------------------RPGR- -RP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPD------------------- ------------------------------------------------------------ -------------------------------------VPK------------------FK P---------ALEPA-------------------TIQPESLVPTIASKPS------ECPK TT---------------------------------------------------------- -------HRPDA------------------------------------------------ -PQIQP----------GSKPP----------------------KQLLP-KPQTP------ -----------AEPD--------------MPPTK---------SVSEPVPFETEAPSMTI VLTTDIEPVTVRTEAPLATLA--------------------------------------- ----------------PKTPPRARTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPITPGTSSAP-------------TTAKRA-------------RRPHPKPK TTPHPE-------VPQTKL----------------------------VPATILE------ ---------------PV-LRTEAPGTTVAPKVP--------------------QRT---- --------------------------------HRPHPKPKTTPSPEELQTDLVPATIFEP VSPIQEAPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTETPATTLA-TKTS KRTRPPRPRI--K-TTPSPQAPETKPVPATVLEPV-------------------TLRPEA P----------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRLRTK ATPRPEAPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELKPVTLRTETWVTTQAPKTSQRTRRP RPKPKTTPS-------------------------------------------P------- -------------EVPQTKPVPATDLEPVTLRTEAPKTMVVTTVLEPDTFRTKVPE-TTL APKA-QRTR-------------RPRP--RPKTT---PEVPQTESVSVTGF------EPVV LSSDAPGTTFAPTELQTLILKPVTSPSLEMTESQPVSDVLESVTFSTESPKETIAPAKTD YVYPTAKAPLWPEEPKTE-VVESITYVSEP-------------PET---TLETSPLPSQS VILP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPP---------------------- --------KPKTSPH------PRIP----------------------------------- --------------QTQ------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -P---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PQKPE----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTTL------------------------------------------------- ------------------EETDQSTQEPFTTKIPRTTELAKTTP---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTTPV-------------------- ------------------RPRISD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -ARP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------GNGV- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------GTGI-------------------------------------------- -----TSSGPVTIPPLRSTV---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTRTPW-D----------- --------R---IATDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDSSPCSITDSVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFNG-NNK SIQLTNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSCJAP00000000941 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLVL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP SLKVHINTTSDSIFLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKARSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKASTKSPEKAPM GGVILVHLIIPGLNETT-VKLPA-SLMF-----------EISDALKTQLAKNETLALPAE SKTPEVEKIPAR---------------------------------------PT------- --------TV-------------------------------------------------- ---TPETVPR---------TAKPTMPSALDVSETTP-VLSKRTPETLQTILIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGALAS-SEKPW----------- -VVPSAKTSEDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPMTSEEPEI SESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TLFVP--------------------------- ------------------------------------------------------------ ---------------------------QNLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------ETQPTAP---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITPKISKSPEPTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QSISLKPKFPLSPEVTHTK--------------------- ---PAPEPQ---------------TPLPSESTIG-------------------------- PETLG-----------TKP----------------------------------------- ---S-TTTLA-PRKTK---------------------------------------RPGR- -RP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPD------------------- ------------------------------------------------------------ -------------------------------------VPK------------------FK P---------AREPA-------------------TILPEPLVPTTASKPS------ESPK TT---------------------------------------------------------- -------HGPDA------------------------------------------------ -PQIQP----------GSKPP----------------------KQLLP-KPQTT------ -----------AEPD--------------MPPTK---------SVSEPVPFETEAPSMTI VPTTGIEPVTVRTEAPVTTLA--------------------------------------- ----------------PKTPPRARTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPITPGTSSAP-------------TTTKRA-------------RRPHPKPK TTPRPE-------VPQTKL----------------------------VPATTLE------ ---------------PV-LRTEAPGTTVASKVP--------------------QRT---- --------------------------------HPPHPKPKTTLSPEELQTDLVPATIFEP VSPIKEAPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTETPATTLA-TKTS KRTRPPRPRI--K-TTPSPQAPETKPVPATVLEPV-------------------TLRPEA P-T--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRLRTK TTPRPEAPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELKPVTLRTETWVTTQAPKTSQRTRRP RPKPKTTPS-------------------------------------------L------- -------------EVPQTKPVPATDLEPVTLRTEAPKTMVGTAVLEPDTFRTKLPE-TTL APKA-QRTR-------------RPRP--RPKTT---PEVPQTKSVSVTGF------EP-V LSSDAPGTTFAPTELQTLILKPVTSPSLEMTQSQPVSGVLESVTFSTESPKETIAPAKTD YVYPTAKAPLWPEESKTE-VAESITYVSEP-------------PET---TLETSPLPSQS VILP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------T------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRASP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQ------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -P---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PQKPD----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTTL------------------------------------------------- ------------------EETDQSTQEPFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTTPV-------------------- ------------------RPRISD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPL IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -ARP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------ARPKPSGMPS----------------GNGVE T------------------------------------------------G---------- ------------------------------------------------------------ -----------MKQAPK------------------------------------------- -------------------------------------------------------PSGA- --------------VRNVSVDS-------------------------------------- ---------------T-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------GSGI-------------------------------------------- -----TSSGPITIPPLRLTV---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPW-D----------- --------R---IATDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDSSPCSITDSVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSSBOP00000010803 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLVL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP SLKVHINTTSDSIFLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKARSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ----------------------KVNGKIQSTYDQDHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ ------------------------------------------------------------ -------------------------------------------------AKNETLALPAE SKTPEVEKIPAR---------------------------------------PT------- --------AV-------------------------------------------------- ---TPETVPR---------SAKPTVPGAFDVSETTL-VLSKRTPETLQTIRIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------V----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTLAS-SEKPW----------- -IVPTAKTSDDSKVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VSSSPMTSEEPGI SESY-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QNLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------ETQPTTP---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITPKISKSPESTWTTPAPS----------KT------ ------------------------------------------------------------ --------------------QSISLKPKIPLSPEVTHTK--------------------- ---PAPEPQ---------------TPLPSESTIG-------------------------- PETLG-----------TKP----------------------------------------- ---S-TTTLA-PRKTK---------------------------------------RPGR- -RP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPD------------------- ------------------------------------------------------------ -------------------------------------VPT------------------FK P---------ALEPV-------------------TIPPEPLVPTIASKPS------ESPK TT---------------------------------------------------------- -------HRPDA------------------------------------------------ -PQIQP----------GSKPP----------------------KQLLP-KPQTT------ -----------AEPD--------------MPPTK---------SVSGPVPFETEAPSMTI VPTTDIEPVTLRTEAPVTTLA--------------------------------------- ----------------PKTPPRARTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPITPGTSSAP-------------TT-KRA-------------RRPHPKPK TTPRPD-------VPQTKL----------------------------VPATILE------ ---------------PV-LRTEAPGTTVAPKAP--------------------PRT---- --------------------------------HPPHPKPKTTPSPEELQTDLVPATIFEP VSPIKEAPGTTFV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTETPATTVA-TKTS KRTRPPRPRV--K-TTRSPQAPETKPVPATVLEPV-------------------TLRPEA P-T--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRLRTK TTPRPEAPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELKPETLRTETWVTTQAPKTSQRTRRP RPKPKTTPS-------------------------------------------L------- -------------EVPQTKPVPVSDLEPVTLRTEAPKTMVVTTGLEPDTFRTKVPE-TTL APKA-PRTR-------------RPRP--RPKTT---PEVPQTKSVSVTGF------EPVV LSSDAPGTTFAPTELQTLILKPVTSPSLEMTQSPPVSDVLESVTFSTESPKETIAPAKTD YVYPTAKSPLWPEESKTE-VVESITHVSEP-------------PET---TLETSPLPSQS IILP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQ------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -P---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PQKPD----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELQTTL------------------------------------------------- ------------------EETDQSTQEPLTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RFYTTPV-------------------- ------------------RPRISD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH TRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -ARP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------MRPKPSGMPS----------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------MRPAPK------------------------------------------- -------------------------------------------------------PSGA- --------------VRNVSVDS-------------------------------------- ---------------P-HP----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SSGI-------------------------------------------- -----TSSGPITIPPLRSTV---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGTPW-D----------- --------R---TATDI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDSSPCSITDSVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFT-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSPCOP00000000251 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALVL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP SLKVHVNTTSDSILLKFLRPSPNVKLEGFLLGYGSNTSPNQYFPLPAEGKYTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPDTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SK-------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYIP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------K------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKASTKSPDKTPF GGAILVHLIVPGLNETT-VKLPT-SIMF-----------EISDALKAQLAKNETLALPAE SKTPEVEKIPAQ---------------------------------------PI------- --------TV-------------------------------------------------- ---TPETVPR---------TTKPTVSSALDVSETTL-VLSKRIPEMSHTVLIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------DFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPEGILVS-SEKPW----------- -IVPTAKTYEDSRVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------IFSSPTTSDEPEI SESH-TATSDRILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DITPVVP--------------------------- ------------------------------------------------------------ ---------------------------QTLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTP---------- -----------------------APLQ--------------------------------- ------------------------------------------------------------ --TTSVPST--------------------------------------------------- ---TKRRH---------------------------RPKR--------------------- -------------------------------------------------P---------- ------------------------------RPK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITSKISKSPEPIWTTLAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTHTK--------------------- ---PAPEPQ---------------TLPPSQSTIG-------------------------- PGTKR-----------PKP----------------------------------------- ---S-TRTLA-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------LK P---------VLEPA-------------------TVQPELLVPTIASKPS------KRPK TT---------------------------------------------------------- -------HRPDV------------------------------------------------ -PQIQP----------DSKPP----------------------KQLLP-KPKTT------ -----------AKPD--------------MPPTK---------SVFDPVPFETEAPLMTI VPTTDIEPVTLRTEAAVTTLA--------------------------------------- ----------------PKTAQRTRTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPVTPETSLAP-------------ATTKRT-------------RRPHPKPK TTPQPE-------VPHTKL----------------------------VPDTILK------ ---------------PI-LGTEAPETTLAPKVP--------------------ERT---- --------------------------------RRPHPKPKTTPRPEAPQTELVPAIVFEP VSPTKETPETALV---------------------------------------P------- -------------------VTDF------------------------------------- ----------------EPVN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------IITETPGTTLA-TKTS QRTRRPRPRP--K-TTSSPRAPQTKPVPATVLEPV-------------------TLKPEA PGT--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRPRQK TTPSPEAPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------EFEPVTLRTEAWVTTQAPKTSKRTRRP RPKPKTTAS-------------------------------------------P------- -------------EAPQTRPVPATDLEPGTLRTEAPETTVLATVLEAVTFRTEAPE-TTL APKT-QRTH-------------RPRP--RPKTT-PSPEVPQTKS---------------- ----------ASTELQTLILKTVTSPSLEMTQSQPASDVLESATFSTESSKETIAPAETD YVYPTAKAPLRPEESKTE-VVESITYVSEP-------------PET---TLEASPLPSQP IILP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPA---------------------- --------KPKTSPR------PRVP----------------------------------- --------------QTQP---------------------------------V-------- ---PKRP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTSKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEMLYP SP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDVLL-PHKPD----PEF-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRDIPFIPMISPSP- --SQEELPTTP------------------------------------------------- ------------------EETDQSTQEPFATKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPV-------------------- ------------------RPRTPE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPR IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------IKQAPQ------------------------------------------- -------------------------------------------------------PSGF- --------------DRDVLVDS-------------------------------------- ---------------Y-HS----------------------------T------------ ----KR------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSDPITSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGAPW-E----------- --------R---TETEI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LDNITDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNSPCSITDSVKRFPK-EEA-TDGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-KENGSFSG-KNK SIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSPSMP00000029294 VRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGRLLLCGSIALVL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP SLKVHVNTTSDSILLKFLRPSPNVKLEGFLLGYGSNTSPNQYFPLPAEGKFAEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPDTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SK-------------------------- ----------------------KVNGKIQSTYDQ---V---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYIP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------K------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKASTKSPDKTPF GGAILVHLIVPGLNETT-VKLPT-SIMF-----------EISDALKAQLAKNETLALPAE SKTPEVEKIPAR---------------------------------------PI------- --------TV-------------------------------------------------- ---TPETVPR---------TTKPTVASALDVSETTL-VLSKRIPETSQTVLIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------DFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPEGILVS-SEKPW----------- -IVPTAKTSEDSRVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTASDEPEI SESH-TATSDSILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DITPLVP--------------------------- ------------------------------------------------------------ ---------------------------QKPEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTP---------- -----------------------APLQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---TKRRQ---------------------------RPKK--------------------- -------------------------------------------------P---------- ------------------------------RPK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------KR-TTSAGTITSKISKSPELTWTTLAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTHTK--------------------- ---PAPEPQ---------------TLPPSQSTIG-------------------------- PGTKR-----------PKP----------------------------------------- ---S-TRTLA-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------LK P---------VLEPA-------------------TVQPELLVSTIASKPP------KRPK TT---------------------------------------------------------- -------HRPDV------------------------------------------------ -PQIQP----------DSKPP----------------------KQLFP-KPQTT------ -----------AKPD--------------MPPTK---------SFFDRVPFETEAPLITI VPTTDIEPIILRTEAPVTTLA--------------------------------------- ----------------PKTSQRTRTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPVTPETSLAP-------------ATTKRT-------------RRPHPKHK TTPQPE-------VPHTKL----------------------------VPDTILK------ ---------------PI-LGTEAPEMTRAPKVH--------------------ERT---- --------------------------------RRPHPKPKTTPRPAAPQTELVPATVFEP VSPTKETPETALV---------------------------------------P------- -------------------VTDF------------------------------------- ----------------EPVN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------IITETPGTTLA-TKTS QRTRRPRPRP--K-TTPSPQAPLTKPVPATVLEPV-------------------TLKPEA PGT--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRPRQK TTPSPEAPESKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------EFEPVTLRTETWVTTQVPKTSKRTRRP RPKPKTTLS-------------------------------------------P------- -------------EAPQTRPVPVTDLEPGTLRTEAPETTVLATVLEPVTFRTEASE-TTL APKT-QRTH-------------RPRP--RPKTT-RSPEVPQTKSVPVPAF------EPVI HSTEAPGITLAPTELQTLILKPVTSPSLEMTRSQPASDVLESVTFSTESSKETIAPAETD YVYPTAKAPLRPEESKTE-VVESITYVSEP-------------PET---TLEASPLPSQP IILP----------RPDEPHTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRVPP---------------------- --------KPKTSPR------PRVP----------------------------------- --------------QTQP---------------------------------V-------- ---PKRP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTSKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVLYP SP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDVLL-PHKPD----PEF-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRDIPFIPMISPIP- --SQEELPTTL------------------------------------------------- ------------------EETDQSTQELFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPV-------------------- ------------------RPRTPE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH VRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------GNGVR T------------------------------------------------G---------- ------------------------------------------------------------ -----------IKQAPQ------------------------------------------- -------------------------------------------------------PSGS- --------------DRDVSVDL-------------------------------------- ---------------Y-HS----------------------------T------------ ----KR------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGV-------------------------------------------- -----VASGPITSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGAPL-E----------- --------R---TETEI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LDNITDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDDSPCSITDSVKRFPK-EEA-TDGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSMICP00000050813 GRGGKC--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALVL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP SLKVHVNTTSDSILLKFLRPSPNVKLEGFLLGYGSNTSPNQYFPLPADGKYTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPDTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SK-------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYIP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------K------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKASTKSPDKSPF GGAILVHLIVPGLNETT-VKLPT-SIMF-----------EISDALKAQLAKNETLALPAE SKTPEVEKIPAQ---------------------------------------PI------- --------TV-------------------------------------------------- ---TPETVPR---------TTKPTVSSALDVSETTL-VLSERIPETSQTVQIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------DFPET----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPEGILVS-SEKPW----------- -IVPTAKTSEDSRVLQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSSTTTDEPEI SESH-TATSDPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------DITPVVP--------------------------- ------------------------------------------------------------ ---------------------------QKPEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EIQPTTP---------- -----------------------APLQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---TKRRQ---------------------------RPKR--------------------- -------------------------------------------------P---------- ------------------------------RPK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTITSKISKSPEPTRTTLAPS----------KT------ ------------------------------------------------------------ --------------------QFISLQTKVPLSPEVTHTK--------------------- ---PAPEPQ---------------TLPPLQSAIG-------------------------- HRTKR-----------PTP----------------------------------------- ---S-TRTLA-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------LK P---------ALEPA-------------------TAQPELLVPTFAPKPS------KRPK TT---------------------------------------------------------- -------HRPDV------------------------------------------------ -PQIQP----------DSKPP----------------------KQLLP-KPKTT------ -----------AKPD--------------MLPTK---------SVFDPVPFETEAPLMTI VPTADIEPITLRTEAPVTRLA--------------------------------------- ----------------PKTSQRARTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPVTPETSLAP-------------ATTKRT-------------RRPHPKPK ITPQPE-------VPHTKL----------------------------VPDTILK------ ---------------PI-LGTEAPETTLAPKVP--------------------ERT---- --------------------------------RRPHPKPKTTPRPEAPQTKLVPATVFEP VSPTRETPETALV---------------------------------------P------- -------------------ATNF------------------------------------- ----------------EPVN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------IITETPGTTLA-TKTS QRTRRPRPRP--K-TTPTPQAPQIKPVPATVLEPV-------------------TLKPEA PQT--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRPRQK TTPSPEAPQSKPVPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------EFEPVTLRTATWVTTQAPKTSKRTRRP RPKPKTTAS-------------------------------------------P------- -------------EAPQTRPVPTTDLEPDTLRTEAPETMVLATVLEPVTFRTEAPE-TTL APKT-QRTRPR----------PRPRP--RPKTT-PSPEVPQTKSVPVPGF------EPVI HSTEAPGITLAHTEMQTLILKPVTSPSLEMTQSQPASDVLESVTFSTESSKETIAPAETD YVSPTAKAPLRPEESKTE-VVEFVTYVSEP-------------PET---TLEASPLPSEP IILP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPA---------------------- --------KPKTSPH------PRVP----------------------------------- --------------QTQP---------------------------------V-------- ---PKRP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTAKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPAVLYP SP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDVLL-PHKPD----PKF-----FQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETGDIPFMPMISPSP- --SQEELPTTL------------------------------------------------- ------------------EETDQSTQELFTTKIPQTTDLAKTTR---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPV-------------------- ------------------RPRTPE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPR IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------TRPKPSGMPS----------------GNGMG T------------------------------------------------G---------- ------------------------------------------------------------ -----------IKQAPQ------------------------------------------- -------------------------------------------------------PSGS- --------------ERDVSMDP-------------------------------------- ---------------Y-RS----------------------------T------------ ----KR------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPM---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----VLSGPITSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RTTGAPL-E----------- --------R---TETEI-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LDNITDFSSSPTKETDPLGKPRFTGPHVRY-LQK PDDSPCSITDSVKRFPK-EEP-TDGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPQN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVY---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSOGAP00000001118 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------G------------------- --------------------------------------------------------K-RP SLRVHVNTTSDSILLKFLRPNPNVKLEGFLLGYGSNTSPNQYFPLPAEGKFTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLSPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVGI-------LSGK-------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------K------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKASTKSPEKTPF GGAILVHLIIPGLNETS-VKLPT-SIMF-----------EISDALKTQLAKNETLALPAE SKTPEVEKIPAR---------------------------------------PM------- --------TV-------------------------------------------------- ---TPEIVPR---------TSKPTVSSALDVSETTL-VLGGRIPETPQTVLIPQFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------KFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KTEGILAS-SEKPW----------- -IVPTAKTSEDSRVLK------------PQT----------------------------- ---------------------------------------------------------AAY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPARTDVPEI PASH-TATSDAILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------EVTPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKPEIVTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTPP---------- -----------------------APLQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---AKRRH---------------------------RPKL--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APESQ---------------TQPLSQSTI--------------------------- ------------------------------------------------------------ ---------A-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------FK P---------ALEPA-------------------TVPPEPSVPTIASKPS------KRPK TT---------------------------------------------------------- -------PRPDA------------------------------------------------ -PQIQ------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPP---------------------- --------KPKTSAH------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKKP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVPSKPKMS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEALYT SP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVLL-PHKPD----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRDIPFIPMISPSP- --SEEELQTTP------------------------------------------------- ------------------EETDVSTHELFTTRIPYTTELAKTTR---------------- ------------------------------------------------------------ --------------------------------------APL------------------- ---------------------------------RLYTTPV-------------------- ------------------RPRTPE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH VRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------SRPKPSGMPS----------------GNGVK T------------------------------------------------G---------- ------------------------------------------------------------ -----------IKQVPQ------------------------------------------- -------------------------------------------------------PTGP- --------------DGDMSVDS-------------------------------------- ---------------S-HT----------------------------T------------ ----RR------------------------------------------------------ ---------------PA------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------TILGT-----RRPPW---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ILSGQITSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGAPL-D----------- --------K---IETEI-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LGNTTDFSSSPTRETDPLGKPRFKGPHVRY-IPK PDNSPCSITDSVKRFPK-EEA-TDGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-KENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSPVAP00000016355 V-GGKY--------------NMLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP SLKVHINTTSDSILLKFLRPSPNT-LEGFLLGYGSNLSPNQYFPLPAEGKYTEAVV--DA EPKYLIVVRPA-PPSKKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP THCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYIP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------VIPITIIKQ------------------------ -----------------------------------------VIQNITHRASTKSPDKTPI GGTILLHLVIPGLNETT-VKLPT-SIMF-----------EISDTIKRQLAKNETLALPAE SKTPKVEKIPAQ---------------------------------------PI------- --------TV-------------------------------------------------- ---TPESVPR---------TTKPTVSSVLDISER-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KLAS-SEKPW----------- -ILPTAKMSEDSKVLP------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPTTSDEPEI SEPH-TATSDPFLE---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------RPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLDIITS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTP---------- -----------------------APLQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRL---------------------------KPKT--------------------- -------------------------------------------------Q---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------PA-------------------------------------------------- --------------GR-TKSPGTTTSKIFKSPEPTWTTLAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKVSLSPEVTHIK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------L------------------------------------------------- ------------------------------KQTPRTPP---------------------- --------KPKTSPR------PRVP----------------------------------- --------------QTQP---------------------------------V-------- ---PKVS----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTSKPKMS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PRPEMPYT PP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPRDVLL-PHKPD----SEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGSPLIPMISPSL- --VQEELQTTL------------------------------------------------- ------------------AETDQFTQEPFTTEIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPV-------------------- ------------------RPRTPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RTH TRP--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQALK------------------------------------------- -------------------------------------------------------PSGA- --------------GGNVSVDS-------------------------------------- ---------------T-HS----------------------------T------------ ----KK------------------------------------------------------ ---------------T-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RHPPL---------A-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGRVTSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGAPS-E----------- --------R---TEIDK-KEPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEY---LGNVTDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNRPCSITDSVKRFPV-EEA-SEGNATSPPQNPPSNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SVQVTNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS---- G------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD TLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGLQLTSDQLPTKKGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSSSCP00000062589 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KP NLKVHINTTSDSIFLKFLRPHPNVKLEGFLLGYGSNLSPNQYFPLPAEGKYTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPQHD-WTLP SQCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPDTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKG------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PSYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------VIPVTIIKQ------------------------ -----------------------------------------VIQNVTHKASAKSPDRTPY GGTILVHLVIPGLNETT-VKLPT-SIMF-----------DISNALKTELAKNETLALPAE SKTPEVEKIPAQ---------------------------------------PI------- --------TA-------------------------------------------------- ---TPESVPR---------TTKPTASSALDISET-------------------------- TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKSLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPQA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KSWGTLAS-SEKPW----------- -IVPTSKTSEDSKILP------------PQ------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----TATSDPFLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SLP------ -----------------------------------------------RKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------PELEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTS---------- -----------------------APLQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRL---------------------------RPKI--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTRPGIITSKISKSPEPTWTTLAPS----------KT------ ------------------------------------------------------------ --------------------PFISLKPKIPLSPEVTHTK--------------------- ---PAPEPE---------------TPPPS------------------------------- ------------------PPP-------IVLEPGTLGTK--------------------- --PS--TTLA-PPKTK---------------------------------------RPGR- -------------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPD------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TVQPEPLGPTV--------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------DSKPP----------------------KQLLP-KPQTT------ -----------AKPD--------------MPPPK---------SVLEPVTSEPEEPSTTI VPDTDIEPVTLRTEALPTTLA--------------------------------------- ----------------PKTSQRTRTRRPR----------------PRPK-PKTTPSPET- --PQAKLDFEPVTPGTSLATT----------TTTTTKRP-------------RRPRPKLK TTPHPE-------VPQTKL----------------------------VPATTPE------ ---------------PVTLRTEAPGTTIAPKVP--------------------QRT---- --------------------------------RHPRPKPKTTPSPEAPHTEPVPATDLEP VTPIKEAP----V---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FPTEISGTTLA-TKAS QRPRRPRPRP--K-TTPSPQVPHTKPVPATALEPV-------------------TLKPEA RGT--------------------------------------------------------- ------------------------------------------TL---------------- ------------VPTA-------------------------------------------- ------------------------------------------------------------ ---------------------------------VFEPVTLRTEAWVMTRAPKTSKRTRRP CPKPKTTPT-------------------------------------------P------- -------------EAPRFKPVSTTDLVPG---TEAPEIMALPTVLEPVIFRTKTPE-TTL VP--------------------------------------------AMSF------EPVT YSSKAPETTLAPIELQTLTLKPVTSPSLDMTQSQPVSEVVESVTFSTESSKEAIVPTETD --YPTAKVPLRPEEPKTE-VVESITYVSEP-------------PETMLVTIETSPLPSQT IILP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRTPP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKVF----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTPKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT PS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPRDVFL-PHKPD----PEV-----SQSEPV------------LQPVT FRIDLPEST------------------------------------------IAP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGSPFIPMISPSS- --SQEELQTTL------------------------------------------------- -------------------ETDQSTQELFTTKLPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLFTTPV-------------------- ------------------RPRTPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH VRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------SRPKPSGMPR----------------GNGIG T------------------------------------------------G---------- ------------------------------------------------------------ -----------IKQTPL------------------------------------------- -------------------------------------------------------PSGP- --------------GRNVSLDS-------------------------------------- ---------------T-HS----------------------------T------------ ----KK-------P---------------------------------------------- ------------AMIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGRVTSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTEAPL-E----------- --------R---IETDK-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GED---LGNMTDFSSSPTRETDPLGKPRFKGPHVRY-IQK PENRPCSITDSVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWDKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQTTNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSFDAP00000008803 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLFCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KP SLKVHINSTSDSILLKFLRPNPNVKLEGFLLGYGSNTSPNQYFPLPTEGKYTEAVV--DA EPKYLIVVRPVPPPSQKKSCSGKARPRKPLQMVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIIG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKASIKSPDKIPF GGTILVHLIIPGLNEST-VKLPS-SIML-----------EISDALKAQLANNETLALPAE SKTPEMEKITAQ---------------------------------------HI------- --------TV-------------------------------------------------- ---TPETVPR---------TTKPTMSSTLDVSETTL-VLTQRAPETLQTILSPKFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRFP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTS------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGVTMVT-QEKSW----------- -MAPTAKTSEDSKVVK------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPSTFDESDI SEPH-TATSDPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFIP--------------------------- ------------------------------------------------------------ ---------------------------QKVETFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------AMKPTTS---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSVPSP--------------------------------------------------- ---PKRRL---------------------------RPKI--------------------- -------------------------------------------------P---------- ------------------------------RTT--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------L--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEPL---------------TLPPPQS----------------------------- ------------------------------------------------------------ -------TKA-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KPT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TVYPESLVPRIVPKPS------KRPK TS---------------------------------------------------------- -------HRSDV------------------------------------------------ -PQIK------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------L------------------------------------------------- ------------------------------RQTPHTPP---------------------- --------KTKTSQH------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKGS----------------------------------------------------- ------------------------------------------------------------ ----------------------PSTTSKLKMP---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------GPEYVPL-PHEPD----PEV-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRRIPFIPIISPSL- --SQEELQPTL------------------------------------------------- ------------------EKIDQSTQELFTTKIPRTTELAKTTP---------------- ------------------------------------------------------------ --------------------------------------ALH------------------- ---------------------------------RYYTTPG-------------------- ------------------RSRIPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KSH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -IKP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------IRPKPSRIPS----------------RNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------AKQAPK------------------------------------------- -------------------------------------------------------PSGS- --------------GRNVSVDS-------------------------------------- ---------------T-QS----------------------------T------------ ----RK-------P---------------------------------------------- ------------ATVP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------RT-----HRLPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SSRI-------------------------------------------- -----ISS-LVTSPPPRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPTETTT-E----------- --------R---QETDR-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LGNTTDFSSSPTRETDHLGKPRFKGPHVRY-IPK PDNRPCSITDSIKRFPT-EEA-MEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS---- G------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQHLFSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSHGLP00100004485 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KT SLKVHINTTSDSILLKFLQPNPNVKLEGFLLGYGSNTSPNQYFPLPTEGKYTEAVV--DA EPKYLIVVRPVPPPSQKKSCSGKARPRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLQ SHCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIIG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYAP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHRASIKSPDKIPF GGTILVHLIIPGLNETT-VKLPS-SIMV-----------EISDALKAQLANNETLALPAE SRTPKVEKTTAQ---------------------------------------HI------- --------TV-------------------------------------------------- ---TPETVPR---------ATKPTVSSTLDISETTR-VLSQRTPETLQTILLPKFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTS------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPEVTLVT-KEKSW----------- -MAPTAKTSEDSKVVK------------PQT----------------------------- ---------------------------------------------------------ATY E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPSTSDEPDI SEPH-TATSDPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SIP------ -----------------------------------------------PKTSRILE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TSFIP--------------------------- ------------------------------------------------------------ ---------------------------QKVETFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------AMKPTTS---------- -----------------------APQK--------------------------------- ------------------------------------------------------------ --TTSIPSP--------------------------------------------------- ---PKRRP---------------------------RPKT--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEPQ---------------TLPPPQS----------------------------- ------------------------------------------------------------ -------TKA-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TVYPESLVPRIVPKPP------KRPK TS---------------------------------------------------------- -------HRPDV------------------------------------------------ -FQIK------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------L------------------------------------------------- ------------------------------RQTPRTPP---------------------- --------KTKTSQH------PRIT----------------------------------- --------------QTQP---------------------------------V-------- ---PKGS----------------------------------------------------- ------------------------------------------------------------ ----------------------PHATSKPKMS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PHPEVSYT TS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------GPEDVPL-PREPD----PEV-----SRSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPIISPSL- --SQEELQPTL------------------------------------------------- ------------------EETDQSTQELFTTKIPRTTESAKTTP---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPW-------------------- ------------------RFRIPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TKP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------VRPKPSGIPS----------------RNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------AKQPPK------------------------------------------- -------------------------------------------------------PSGS- --------------GRNVSVDS-------------------------------------- ---------------T-QY----------------------------T------------ ----RK-------P---------------------------------------------- ------------GTIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------RT-----HHPPL---------P-----S-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SSRI-------------------------------------------- -----ISS-RVTSPPMRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPTETTS-E----------- --------I---KEADK-RQPTP------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LGNTTDFSSSPTRETDHLGKPRFKGPHVRY-IPK PDNRPCSITDSIKRFPT-EEV-MEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DSVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS---- G------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLSG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGHHLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSHGLP00000003685 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSITLAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KT SLKVHINTTSDSILLKFLQPNPNVKLEGFLLGYGSNTSPNQYFPLPTEGKYTEAVV--DA EPKYLIVVRPVPPPSQKKSCSGKARPRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLQ SHCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIIG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYAP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHRASIKSPDKIPF GGTILVHLIIPGLNETT-VKLPS-SIMV-----------EISDALKAQLANNETLALPAE SRTPKVEKTTAQ---------------------------------------HI------- --------TV-------------------------------------------------- ---TPETVPR---------ATKPTVSSTLDISETTR-VLSQRTPETLQTILLPKFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTS------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPEVTLVT-KEKSW----------- -MAPTAKTSEDSKVVK------------PQT----------------------------- ---------------------------------------------------------ATY E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPSTSDEPDI SEPH-TATSDPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SIP------ -----------------------------------------------PKTSRILE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TSFIP--------------------------- ------------------------------------------------------------ ---------------------------QKVETFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------AMKPTTS---------- -----------------------APQK--------------------------------- ------------------------------------------------------------ --TTSIPSP--------------------------------------------------- ---PKRRP---------------------------RPKT--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEPQ---------------TLPPPQS----------------------------- ------------------------------------------------------------ -------TKA-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TVYPESLVPRIVPKPP------KRPK TS---------------------------------------------------------- -------HRPDV------------------------------------------------ -FQIK------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------L------------------------------------------------- ------------------------------RQTPRTPP---------------------- --------KTKTSQH------PRIT----------------------------------- --------------QTQP---------------------------------V-------- ---PKGS----------------------------------------------------- ------------------------------------------------------------ ----------------------PHATSKPKMS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PRPEVSYT TS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------GPEDVPL-PREPD----PEV-----SRSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPIISPSL- --SQEELQPTL------------------------------------------------- ------------------EETDQSTQELFTTKIPRTTESAKTTP---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPW-------------------- ------------------RFRIPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TKP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------VRPKPSGIPS----------------RNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------AKQPPK------------------------------------------- -------------------------------------------------------PSGS- --------------GRNVSVDS-------------------------------------- ---------------T-QY----------------------------T------------ ----RK-------P---------------------------------------------- ------------GTIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------RT-----HHPPL---------P-----S-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SSRI-------------------------------------------- -----ISS-RVTSPPMRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPTETTS-E----------- --------I---KEADK-RQPTP------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LGNTTDFSSSPTRETDHLGKPRFKGPHVRY-IPK PDNRPCSITDSIKRFPT-EEV-MEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DSVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS---- G------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLSG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGHHLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSODEP00000007853 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KP SLKVHINTTSDSILLRFLRPSPNVKLEGFLLGYGSNVSPNQYFPLPTEGKYTEAVV--DA EPKYLIVVRPVPPPSQKKSCSGKSRPRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVDNLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PSYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPVTIIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKPPF GGTILVHLIIPGLNETA-VKLPS-SIML-----------EISDALRAHLAKNETLALPTE SKTPEVEKTTTQ---------------------------------------HI------- --------TV-------------------------------------------------- ---IPEIVPR---------TTKPTVSSTLGISETTL-VLSQRTPETLQTILLPKFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRFP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------GFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTS------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KSGVTLVT-SEKSW----------- -VAPEAKTLEDSKLVK------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPSTSDEPDV SEPS-TATSDPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SIP------ -----------------------------------------------PKTPRTPQ----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-APFIP--------------------------- ------------------------------------------------------------ ---------------------------QQVDTFTR------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------ATQPTTQ---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --ITSIPST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APESQ---------------TLPLPQS----------------------------- ------------------------------------------------------------ -------TKA-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SE P---------ALEPAPVE---------PLVARLP------------PKPS------KRPK TP---------------------------------------------------------- -------HRPDV------------------------------------------------ -PQIE------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------L------------------------------------------------- ------------------------------RQTPRTPP---------------------- --------KTKASQH------PRIP----------------------------------- --------------LTQP---------------------------------A-------- ---PRGS----------------------------------------------------- ------------------------------------------------------------ ----------------------PQATSKPKMS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TY---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------GPEDVPI-PHEPD----PDI-----SQSEP------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPLIPIISPSL- --GQEELLPTF------------------------------------------------- ------------------EETDHTIQELFTTKIPQTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APR------------------- ---------------------------------RLYTTPM-------------------- ------------------RPRISD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH IRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------IRPKPTGIPS----------------RNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------AKQGPK------------------------------------------- -------------------------------------------------------PWGP- --------------GRNVSVDL-------------------------------------- ---------------T-QL----------------------------T------------ ----KR-------P---------------------------------------------- ------------ATIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SSGI-------------------------------------------- -----ISSHRVTSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPTLTTS-D----------- --------T---PETNK-KPPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LGNTTDFSSSPTRETDHLGKPRFKGPHVRY-IPK PDNKPCSITDSISRFPT-EEA-MEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQHLSAEQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSCLAP00000023375 ---------------------MPSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KP SLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNVSPNQYFPLPTEGKYAEAVV--DA EPKYLIVVRPVPPPSQKKSCSGKTRARKPLQLVVGTLSPSSVFLSWGFLINPHHD-WTLP SHCPND-RLYTIRYR--EKDKEKK-WIFQLCPATETIVDNLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYIP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPVTIIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTPF GGTILVHFIIPGLNDTS-AKLPP-SIML-----------EISDALKAQLAKNETLALPVE SKTLEVDKITAQ---------------------------------------HI------- --------TV-------------------------------------------------- ---TPETVPR---------TTKPTMSSTPDISQTAL-VLSQRTQETLQTILLPKFELPRS TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKGLL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTS------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KFGVTSVT-SEKSW----------- -MAPAAKTLGDSGVVK------------PHT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VPSSPSTSDEPGI SEPP-TATSDPTLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-APFIP--------------------------- ------------------------------------------------------------ ---------------------------QKVETFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------APKPTTH---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRL---------------------------RPKT--------------------- -------------------------------------------------P---------- ------------------------------RT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----K------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------L------------------------------------------------- ------------------------------RQTPRTTP---------------------- --------KTKTSQH------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKGP----------------------------------------------------- ------------------------------------------------------------ ----------------------PRATSRPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSHT TY---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------GPEDVPF-PHEQD----PDV-----SQSEPV------------LQPVT FRIEPPKTT------------------------------------------TAP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SETRGIPLIPIISPSL- --SQEELLPTF------------------------------------------------- ------------------EETDQTTQELFTTKIPQTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APR------------------- ---------------------------------RLYTIPV-------------------- ------------------RPRIPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPP VRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TKP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------IRPRPSGIPS----------------RNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------PKQGPK------------------------------------------- -------------------------------------------------------PSGP- --------------VRNVSVDS-------------------------------------- ---------------T-QA----------------------------T------------ ----KR-------P---------------------------------------------- ------------ATIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SSGI-------------------------------------------- -----ISSHRVTSPPLKATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPTLTTS-E----------- --------R---PETDK-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---FGNTTDFSSSPTRETDHLGKPRFKGPHVRY-IPK PESKPCSITDSVQRFPT-EEA-MEGHATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQVTNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------QFYNIGDQRGHGEDHC QFVDSFLDGRTGQHLSPDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSTSYP00000031901 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------K-KP HLKVHINTTSDSVFLKFLRPSPNVKLEGFLLGYGSNISPNQYFPLPAEGKSTEAVV--DA EPKYLIVVRPAPPPSHKKSCSGKTRPRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SK-------------------------- ----------------------KVNGKIQSTYDQVHSV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKASTKSPEKTPF GGVILVHLIIPGLNETT-VKLPA-SVML-----------EISDALKTQLAKNETLALPAE SKTPEVEKIPAW---------------------------------------PI------- --------TV-------------------------------------------------- ---TPETVPR---------TTKPTMSSALDVSETTL-VPSERTLETSRTFLIPQFELLLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPDA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPEGTLASPSEKPW----------- -IMPTAKTAEDSKILL------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSPPTSDEPEI SESY-TATSEPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LASS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------RKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVQPTTL---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPSA--------------------------------------------------- ---PKRRP---------------------------KPKP--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ER-TTSAGTFTSKISKSPEPTRTTLAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKIPLSPEVTHTK--------------------- ---PAPEPQ---------------TLLPSQSTIG-------------------------- PETLG-----------TKP----------------------------------------- ---S-TTTLA-PPKTK---------------------------------------RPGRR PRP----------------------RPR-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TEQPELLVPTIASKPS------KRPK TT---------------------------------------------------------- -------HRPDE------------------------------------------------ -PQIQP----------DLKPP----------------------KQFFP-KPQTT------ -----------ANPD--------------MPPTK---------SVFEAVPFETEVPSMTI VPTTAIEPKTLRTETPETTLA--------------------------------------- ----------------PKTP-RARTR--R----------------PRPK-HKTTPRPET- --PQTKLDFGPVTPGISLAP-------------TTTKRP-------------RRPHRKPK TTPHPE-------VPQTKL----------------------------VPATALE------ ---------------PV-LRTEAPGTTLAPEVP--------------------QQT---- --------------------------------RHPHPKPKTTPSPEVPQTELVPATVFEP VSPIKEAPGTAFV---------------------------------------P------- -------------------VTEL------------------------------------- ----------------DPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FRTETPGTTIA-TTTS QRTRRPRPRP--K-TTPSSQAPQTKMVPATVLEPV-------------------VLRTEA SGT--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRPRPK TTPSPERPESKLVPTT-------------------------------------------- ------------------------------------------------------------ ---------------------------------ALEPDMLRTETWVTTQAPKTSQRTRRP RPKPKTTPS-------------------------------------------P------- -------------EAPQTKPVPSTDLEPGTLRTETPEIKAVATVLQPETFRTEAPE-TTL APKA-QRTR-------------RPRP--RPKTT-SSPEVPQTKLVPVPGF------EPVI PSTEASVTTFAPTELKTLTLKPVTSPSLEMTQSQPVSDVLESVTFSTETSKETIAPAETD YVYPTAKAPLRPEEPKTE-VMESITHVSEP-------------PET---TLETSPLPSQT IILP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRAPS---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QIQP---------------------------------V-------- ---PKGP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVTSKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------APKDVFL-PHKPD----PEV-----SQSEP------------------ ----------------------------------------------------AL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFMPMISPSP- --SQEELQTTL------------------------------------------------- ------------------EETDQFTRELFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPG-------------------- ------------------RPRSPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPH FRPFL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------PRPKPSGMPN----------------GNGVG A------------------------------------------------G---------- ------------------------------------------------------------ -----------VKKPPK------------------------------------------- -------------------------------------------------------PISV- --------------GRNVSVDS-------------------------------------- ---------------S-HL----------------------------T------------ ----KK------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPSRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGV-------------------------------------------- -----ISSGPITSPPLRSTL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGAPL-E----------- --------E---TETDT-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---LGNITDFSSSPTRETDHLGKPRFKGPHVRY-IPK PDTSPCSITDSVRRFPT-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPQN DTVT-E------------------------------------YEVIS-TENGSFSG-KDK SIQVTNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPIS---- A------GRDAIWTERPFD-S--DSYSECKGKQFVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSMUSP00000036257 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KP SLKVHINTTSDSILLKFLRPNANVKLEGFLLGYGSNVSPNQYFPLPTEGKFTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRPRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPSD-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNIEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHSV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------P--VP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPLTIIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTPF GGTILVHLIIPGLNEST-VKLPT-SIML-----------EISDALKAQLAKNETLALPAE SKTPEVEKLAGQ---------------------------------------PV------- --------TV-------------------------------------------------- ---TPESVSR---------STKPTLSSALDTAETAL-VLSEKTSETARSVLIPEFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRFP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTA------------------------------ ------------------------------------------------------------ -----------------FPLE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPRGSWAS-SEEPW----------- -VVPGAKTSEDSRVVQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VISSSTTSDETEI -EIH-TATRDPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTAE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPI-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-ALFES--------------------------- ------------------------------------------------------------ ---------------------------RNVEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVRPTTA---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRQS---------------------------TPKP--------------------- -------------------------------------------------P---------- ------------------------------RVK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEPE---------------TRPSAQTT---------------------------- --------------------------------------K--------------------- ---------A-PRKTK---------------------------------------KPGHH ---------------------------R-------------------------------- --------------LRR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TVTPEILVPKIVPKPP------QKPK AT---------------------------------------------------------- -------RRPEV------------------------------------------------ -PQVKPA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------RQTTSMPP---------------------- --------KLK------------------------------------------------- ----------------TPH------------------------SRMPAKEPV-------- ---PKEP----------------------------------------------------- ------------------------------------------------------------ ----------------------LHTTSKPKMP---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVADT TS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDERL-SLKPD----PEV-----THSET------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPLIPVISPRP- --SQEELQTAM------------------------------------------------- ------------------EETDQSTQELFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLHTAPV-------------------- ------------------RPRIPG------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPH GRPAL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------DKTKPRGTSH----------------KNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------TKQAPK------------------------------------------- -------------------------------------------------------PPSP- --------------GRNASVD--------------------------------------- ---------------S-HA----------------------------T------------ ----RK-------P---------------------------------------------- ------------GSVS-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPI---------PHRHSST-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VSPER RPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------RAGI-------------------------------------------- -----VSSSRVTSPPLKATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------HPIGTAT-A----------- --------R---PGAEQ-KEPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---FGTTTDFSSSPTKETDPLGKPRFIGPHVRY-IPK PENKPCSITDSVRRFPT-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPIS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSEQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSMSIP00000023319 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KP SLKVHINTTSDSILLKFLRPNANVKLEGFLLGYGSNVSPNQYFPLPTEGKFTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRPRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPSD-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNIEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHSV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------P--VP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPLTIIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTPF GGTILVHLIIPGLNEST-VKLPT-SIML-----------EISDALKAQLAKNETLALPAE SKTPEVEKLAGQ---------------------------------------PV------- --------TV-------------------------------------------------- ---TPESVSR---------STKPTLSSALDTAETAL-VLSEKTSETARSVLIPEFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRFP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTA------------------------------ ------------------------------------------------------------ -----------------FPLE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPRGSWAS-SEEPW----------- -VVPGAKTPEDSRVVQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VISSSTTSDETEI -EIH-TATRDPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTAE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPI-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-ALFES--------------------------- ------------------------------------------------------------ ---------------------------RNVEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVRPTTA---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRQS---------------------------TPKP--------------------- -------------------------------------------------P---------- ------------------------------RVK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEPE---------------TRPSAQTT---------------------------- --------------------------------------K--------------------- ---------A-PRKTK---------------------------------------KPGHH ---------------------------R-------------------------------- --------------LRR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TVTPEILVPKIVPKPP------QKPK AT---------------------------------------------------------- -------HRPEV------------------------------------------------ -PQVKPAHE-PVTFG--------------------------------------------- ----------------------------------------------------SEAPALAI VTTTDIEPVITRTKASVTTLA--------------------------------------- ----------------PKPP-RPRTH--RQRTKYKTTQ------SPK-----------I- --PHSKPDLGPITPEPPLA--------------STTKKV-------------RRPRPKPQ TTPHPE-------VPHTIL----------------------------VPATSLE------ ---------------PF-IITEAPGTTLVPKLP--------------------QQP---- --------------------------------GYPHPKPKTTRSPAASPTELVPTPVFEP VTPLKEDPVTTIV---------------------------------------P------- -------------------ITDL------------------------------------- ----------------ERVTD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------LETPVAFRTEAPGTTLA-SKIS QRTHRPRPRPRPK-ATLNPQAPETKTVPAVVLEPV-------------------TLRPE- ------------------------------------------------------------ ------------------------------------------------------------ ---------------VQ------------------------------------------- -------------------------------------VTTL------------------A PQKTQKKHRPSPKPKPVPSPEVTESKPVLPRVRE--PVTLRTETWVTTKAPKTPKRTRRP RPKPQTTPT-------------------------------------------P------- -------------ETPLTKPVAATDLEPSALSTEVPATVVLATALTPVTLRTKAPKTTTL APNV-QRTR-------------RPHP--RPKTT-ASTGVSESKS---------------- ----------APTELQSLVLKPVTSPSLEIIQSQSVSDDLELVAFSTESPQKTI------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------V------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------RQTTSMPP---------------------- --------KLK------------------------------------------------- ----------------TPH------------------------SRMPAKEPV-------- ---PKEP----------------------------------------------------- ------------------------------------------------------------ ----------------------LHTTSKPKMP---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVADT TS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDERL-SLKPD----PEV-----THSETV------------LPPVT FRVEPPKTT------------------------------------------IAP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPLIPVISPRP- --SQEELQTAM------------------------------------------------- ------------------EETDQSTQELFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLHTAPV-------------------- ------------------RPRIPG------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPH GRPAL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------DKTKPRGPSH----------------KNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------TKQAPK------------------------------------------- -------------------------------------------------------PPSP- --------------GRNASVD--------------------------------------- ---------------S-HA----------------------------T------------ ----RK-------P---------------------------------------------- ------------GSVS-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPI---------PHRHSSS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------MSPER RPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----VSSSRVTSPPLKATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPIGTAT-A----------- --------R---PGAEQ-KEPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---FGTTTDFSSSPTKETDPLGKPRFIGPHVRY-IPK PENKPCSITDSVRRFPT-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPIS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSEQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >MGP_SPRETEiJ_P0043776 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KP SLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNVSPNQYFPLPTEGKFTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRPRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPSD-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNIEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHSV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------P--VP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPLTIIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTPF GGTILVHLIIPGLNEST-VKLPT-SIML-----------EISDALKAQLAKNETLALPAE SKTPEVEKLAGQ---------------------------------------PV------- --------TV-------------------------------------------------- ---TPESVSR---------STKPTLPSALDTAETAL-VLSEKTSETARSVLIPEFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRFP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTA------------------------------ ------------------------------------------------------------ -----------------FPLE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPRGSWAS-SEEPW----------- -EVPGAKTSEDSRVVQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VISSSTTSDETEI -EIH-TATRDPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTAE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPI-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-ALFES--------------------------- ------------------------------------------------------------ ---------------------------RNVEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVRPTTA---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRQS---------------------------TPKP--------------------- -------------------------------------------------P---------- ------------------------------RVK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEPE---------------IRPSAQTT---------------------------- --------------------------------------K--------------------- ---------A-PRKTK---------------------------------------KPGHH ---------------------------R-------------------------------- --------------LHH----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TVTPEILVPKIVPKPP------QKSK AT---------------------------------------------------------- -------RRPEV------------------------------------------------ -PQVKPA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------RQTTSMPP---------------------- --------KLK------------------------------------------------- ----------------TPH------------------------SRMPAKEPV-------- ---PKVP----------------------------------------------------- ------------------------------------------------------------ ----------------------LHTTSKPKMP---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVADT TS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDERL-SLKPD----PEV-----THSET------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPLIPVISPRP- --SQEELQTAM------------------------------------------------- ------------------EETDQSTQELFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLHTAPV-------------------- ------------------RPRIPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPH GRPAL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------DKTKPRGTSH----------------KNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------TKQAPK------------------------------------------- -------------------------------------------------------PPST- --------------GRNASVD--------------------------------------- ---------------S-HA----------------------------T------------ ----RK-------P---------------------------------------------- ------------GSVS-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPI---------PHRHSSP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------MSPER RPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------RAGI-------------------------------------------- -----VSSSRVTSPPLKATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPFGTAT-A----------- --------R---PGAEQ-KEPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---FGTTTDFSSSPTKETDPLGKPRFIGPHVRY-IPK PENKPCSITDSVRRFPT-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPIS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSEQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >MGP_CAROLIEiJ_P0041899 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KP SLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNVSPNQYFPLPTEGKFTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRPRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCQSD-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNIEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHSV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------P--VP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPLTIIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTPF GGTILVHLIIPGLNEST-VKLPT-SIML-----------EISDALKAQLAKNETLALPAE SKTPEVEKVAGQ---------------------------------------PV------- --------TV-------------------------------------------------- ---TPESVSR---------STKPTLSSALDTAETAL-VLSEKTSETARSVLIPEFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRFP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTA------------------------------ ------------------------------------------------------------ -----------------FPLE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGVSWAS-SEEPW----------- -VVPGAKTSEDSRVVQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VISSSTTSDETEV -ELR-TATRDPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTAE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPI-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------K-ALFES--------------------------- ------------------------------------------------------------ ---------------------------RNVEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVRPTTA---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRLS---------------------------TPKP--------------------- -------------------------------------------------P---------- ------------------------------RVK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEPE---------------TRSSAQST---------------------------- --------------------------------------K--------------------- ---------A-PRETK---------------------------------------KPGRH ---------------------------R-------------------------------- --------------LRR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALESA-------------------TVTPEILVPKIVPKPP------QKPK AT---------------------------------------------------------- -------RRPEV------------------------------------------------ -PQVKPA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------RQTTSMPP---------------------- --------KLK------------------------------------------------- ----------------TPH------------------------SRMPAKEPV-------- ---PKVP----------------------------------------------------- ------------------------------------------------------------ ----------------------LHTTSKPKLP---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVADT TS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDERL-SLKPD----PEV-----THSET------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPLIPVISPRP- --SQEELQTAM------------------------------------------------- ------------------EETDQSTQELFTTKIPRTTEMAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLHTAPV-------------------- ------------------RPRIPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPH GKPAL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------DKTKPRGTSH----------------KNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------TKQAPK------------------------------------------- -------------------------------------------------------PPST- --------------GRNASVD--------------------------------------- ---------------S-HA----------------------------T------------ ----RK-------P---------------------------------------------- ------------GSVS-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPI---------PHRYTSP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VPPQR RPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----VSSSRVTSPPLKATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPIGTAT-E----------- --------R---PGAEQ-KGPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---FGTTTDFSSSPTKETDHLGKPRFIGPHVRY-IPK PENKPCSITDSVRRFPT-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPIS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSEQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >MGP_PahariEiJ_P0029260 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KP SLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNVSPNQYFPLPTEGKFTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRPRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPSD-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNIEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHSV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPLTIIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTPL GGTILVHLIIPGLNEST-VKLPT-SIML-----------EISDALKAQLAKNETLALPAE SKTPEVEKVAGQ---------------------------------------PV------- --------TV-------------------------------------------------- ---IPETVSR---------STKPTLSSALDTAETAL-VLSEKTSETARSVLIPEFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRFP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTT------------------------------ ------------------------------------------------------------ -----------------FPLE--------------------------------------- ------------------------------------------------------------ -----------------------------------RPGGSWAS-SEEPW----------- -VVPGAKTSEDSRVVQ------------PQT----------------------------- ---------------------------------------------------------ATS D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VISSSTTPDETEI -ELH-TATSDPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTAE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPI-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-ALFES--------------------------- ------------------------------------------------------------ ---------------------------RNVEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVRPTTP---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRQS---------------------------TPKP--------------------- -------------------------------------------------P---------- ------------------------------RVK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEPE---------------TRPSAQST---------------------------- --------------------------------------K--------------------- ---------A-PRETK---------------------------------------KPGRH ---------------------------R-------------------------------- --------------LRR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TMPPESLVPKIVPKLP------QRPK AT---------------------------------------------------------- -------RRPEV------------------------------------------------ -PQVKPA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------RQTTSVPP---------------------- --------KLN------------------------------------------------- ----------------IPH------------------------SRMPAKEPV-------- ---PKGP----------------------------------------------------- ------------------------------------------------------------ ----------------------LHTTSKPKMP---------------------------- ------------------------------------------------------------ ----------------------------------------------------PNPEGADT TS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDERL-SFKPD----PEV-----SHSET------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPLIPVISPRP- --GQEELQTTM------------------------------------------------- ------------------EDTDHSTQELFTTKIPPTTELAKTTR---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLHTAPV-------------------- ------------------RPRIPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPH GRPAL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------DKTKPRGTSH----------------KNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------TKQVPK------------------------------------------- -------------------------------------------------------PPST- --------------GRNASVD--------------------------------------- ---------------S-HA----------------------------P------------ ----RK-------P---------------------------------------------- ------------GSVS-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPSI---------PHRHTSP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VPPQR RPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SMGI-------------------------------------------- -----VSSSRVTSPPLKATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPIGTAT-E----------- --------R---PRAEQ-KEPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---FGNTTDFSSSPTKETDHLGKPRFTGPHVRY-IPK PENKPCSITDSVRRFPT-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPIS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSRNOP00000049004 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------G------------------- --------------------------------------------------------K-KP SLKVHINTTSDSVLLKFLRPNPNVKLEGFLLGYGSNVSPNQYFPLPTEGKFTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRTRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCSSD-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNIEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHSV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKIPF GGTILVHLIIPGLNDST-VKLPS-SIML-----------EISDALKAQLAKNETLALPAE SKTPEVEKVAGQ---------------------------------------PV------- --------TV-------------------------------------------------- ---TPETVSR---------STKPTLASALDTAETAL-VLSEKTPETAQSVLIPESELLLS SL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKGSP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTA------------------------------ ------------------------------------------------------------ -----------------FPSE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGSLAS-SEEPW----------- -VVPGAKTSEDSRVVQ------------PRT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VVSSSATSDETEV -EPH-TATSDPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTAE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-ASFDP--------------------------- ------------------------------------------------------------ ---------------------------RTVEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVRPTTA---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRQS---------------------------TPKP--------------------- -------------------------------------------------P---------- ------------------------------RVK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEPE---------------TRPSAQST---------------------------- --------------------------------------K--------------------- ---------APPHKTK---------------------------------------KPGR- ------------------------------------------------------------ ---------------RR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPA-------------------TVPPEILVPTIVPKPP------QRPK AT---------------------------------------------------------- -------RRPEA------------------------------------------------ -PQIQPA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------RQTTSPPP---------------------- --------KLK------------------------------------------------- ----------------PPH------------------------SRRPAKEQV-------- ---PKGS----------------------------------------------------- ------------------------------------------------------------ ----------------------LHTTSKPKMP---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVVDI TS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDEQL-SHKPD----PEV-----SQSET------------------ ----------------------------------------------------VP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRDIPLIPVISPRP- --SEEELQTTM------------------------------------------------- ------------------EQTDQSTQELFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLHTTPV-------------------- ------------------RPRIPE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPH GRPAL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------DRTKSRGMSH----------------KNGVG P------------------------------------------------G---------- ------------------------------------------------------------ -----------TKQTPK------------------------------------------- -------------------------------------------------------PSST- --------------GRNTSVD--------------------------------------- ---------------S-HA----------------------------T------------ ----RK-------P---------------------------------------------- ------------GLIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----R--------------HRHTSP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VPPQR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSSRATSPPLKATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPTGTAT-E----------- --------R---PGAEK-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---FGNTTDFSSSPTKETDPLGKPRFIGPHVRY-IPK PDNKPCSITDSVRRFPT-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPIS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSCGRP00001017085 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KP NLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNVSPNQYFPLPTEGKVTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SNCPND-RYYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNIEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKASTKAPDKTPF GGTILVHLIIPGLNDSM-VKLPT-SIML-----------EISDALKAQLDKNETLALPVE SKTPEVEKVAAQ---------------------------------------PV------- --------TV-------------------------------------------------- ---TPETVSR---------SIKPTVSSVLDTTETTL-VLSEKTPETAHSVLIPEFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRFP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFP------------------------------------------- ------------------------------------------------------------ ------------------------------KTK--------------------------- ------------------------------------------------------------ ------TT--------VFPLE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGDILVS-SEEQW----------- -VSPGAKTSEDSKFVQ------------PQT----------------------------- ---------------------------------------------------------ATH G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VISSSTTSDETEV -EPH-PAASDPTLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTPE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-ASFDP--------------------------- ------------------------------------------------------------ ---------------------------QNVKIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVQPTTT---------- -----------------------ALQE--------------------------------- ------------------------------------------------------------ --TTSVPTT--------------------------------------------------- ---PKR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RQP-----------EI----- -FLS----LA-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------SPE------------------SK P---------ALEPA-------------------TVPRELLVPTIVPKPS------QIPK ST---------------------------------------------------------- -------RRPEV------------------------------------------------ -PQIQP------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------RQTPRPPP---------------------- --------KFKTTPR------PRIP----------------------------------- --------------PQPP---------------------------------V-------- ---PRGS----------------------------------------------------- ------------------------------------------------------------ ----------------------QHITSKPKLP---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVMDT TS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDEQL-SHKTD----PEV-----SHSET------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPVISPRP- --SQEELQTVL------------------------------------------------- ------------------EETDQSTQELFTTKIPQTTEVAKTTR---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RVHTTPV-------------------- ------------------RPRIPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPH ARPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TKP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------GKTKPKVIPH----------------GNGAG T------------------------------------------------G---------- ------------------------------------------------------------ -----------TKQAPK------------------------------------------- -------------------------------------------------------PSSA- --------------GRNMSVD--------------------------------------- ---------------S-HA----------------------------T------------ ----KK-------P---------------------------------------------- ------------ATIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPSM---------PPRPMPP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VSPQR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSSRATSPPPKATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPTGTAA-E----------- --------R---PEAEK-KHPTT------------------------------------- ------------------------------------------------------------ -PS--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---IGTMTDFSSSPTKETDHLGKPRFVGPHVRY-IPK PDNRPCSITDSVRRFPT-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTES-------------- -GNHVSTGRDAIWTERPFN-S--DSYSDCKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSCGRP00000021081 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KP NLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNVSPNQYFPLPTEGKVTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SNCPND-RYYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNIEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKASTKAPDKTPF GGTILVHLIIPGLNDSM-VKLPT-SIML-----------EISDALKAQLDKNETLALPVE SKTPEVEKVAAQ---------------------------------------PV------- --------TV-------------------------------------------------- ---TPETVSR---------SIKPTVSSVLDTTETTL-VLSEKTPETAHSVLIPEFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRFP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFP------------------------------------------- ------------------------------------------------------------ ------------------------------KTK--------------------------- ------------------------------------------------------------ ------TT--------VFPLE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGDILVS-SEEQW----------- -VSPGAKTSEDSKFVQ------------PQT----------------------------- ---------------------------------------------------------ATH G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VISSSTTSDETEV -EPH-PAASDPTLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTPE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-ASFDP--------------------------- ------------------------------------------------------------ ---------------------------QNVKIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVQPTTT---------- -----------------------ALQE--------------------------------- ------------------------------------------------------------ --TTSVPTT--------------------------------------------------- ---PKR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RQP-----------EI----- -FLS----LA-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------SPE------------------SK P---------ALEPA-------------------TVPRELLVPTIVPKPS------QIPK ST---------------------------------------------------------- -------RRPEV------------------------------------------------ -PQIQP------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------RQTPRPPP---------------------- --------KFKTTPR------PRIP----------------------------------- --------------PQPP---------------------------------V-------- ---PRGS----------------------------------------------------- ------------------------------------------------------------ ----------------------QHITSKPKLP---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVMDT TS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDEQL-SHKTD----PEV-----SHSET------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPVISPRP- --SQEELQTVL------------------------------------------------- ------------------EETDQSTQELFTTKIPQTTEVAKTTR---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RVHTTPV-------------------- ------------------RPRIPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPH ARPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TKP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------GKTKPKVIPH----------------GNGAG T------------------------------------------------G---------- ------------------------------------------------------------ -----------TKQAPK------------------------------------------- -------------------------------------------------------PSSA- --------------GRNMSVD--------------------------------------- ---------------S-HA----------------------------T------------ ----KK-------P---------------------------------------------- ------------ATIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPSM---------PPRPMPP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VSPQR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSSRATSPPPKATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPTGTAA-E----------- --------R---PEAEK-KHPTT------------------------------------- ------------------------------------------------------------ -PS--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---IGTMTDFSSSPTKETDHLGKPRFVGPHVRY-IPK PDNRPCSITDSVRRFPT-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTES-------------- -GNHVSTGRDAIWTERPFN-S--DSYSDCKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSCGRP00015015091 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-KP NLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNVSPNQYFPLPTEGKVTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SNCPND-RYYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNIEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHKASTKAPDKTPF GGTILVHLIIPGLNDSM-VKLPT-SIML-----------EISDALKAQLDKNETLALPVE SKTPEVEKVAAQ---------------------------------------PV------- --------TV-------------------------------------------------- ---TPETVSR---------SIKPTVSSVLDTTETTL-VLSEKTPETAHSVLIPEFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRFP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFP------------------------------------------- ------------------------------------------------------------ ------------------------------KTK--------------------------- ------------------------------------------------------------ ------TT--------AFPLE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGDILVS-SEEQW----------- -VSPGAKTSEDSKFVQ------------PQT----------------------------- ---------------------------------------------------------ATH G----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VISSSTTSDETEV -EPH-PAASDPTLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTPE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-ASFDP--------------------------- ------------------------------------------------------------ ---------------------------QNVKIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVQPTTT---------- -----------------------ALQE--------------------------------- ------------------------------------------------------------ --TTSVPTT--------------------------------------------------- ---PKR------------------------------------------------------ ------------------------------------------------------------ --------------------------------P--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APKPD---------------TLPSARST---------------------------- --------------------------------------K--------------------- ---------A-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------SPE------------------SK P---------ALEPA-------------------TVPRELLVPTIVPKPS------QIPK ST---------------------------------------------------------- -------RRPEV------------------------------------------------ -PQIQPAYE-PAAFG--------------------------------------------- ----------------------------------------------------TEAPSLAI VATTDIEPVIMRTKAPVTTLA--------------------------------------- ----------------PKPS-RPRSR--R----------------PRPPKDKATPSPKI- --PQTKPDLGPITPEPSLA--------------STTKKA-------------RRPRPKPK TTPHPE-------VPQTVL----------------------------VPATTLE------ ---------------PV-IRTEAPGMTLAPKLP--------------------QQP---- --------------------------------SHPHPKPKTTRRPAAPQTEPVSTPVFEP VT-----PVATIV---------------------------------------P------- -------------------ITDL------------------------------------- ----------------EPVTD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------LEMPVAFRTEAPGTTLA-SKLS QRTRRPRPRP--K-STMSPQAPQTKPVPPVVLEPV-------------------TLRPEA PVT--------------------------------------------------------- ------------------------------------------TLATKTSQRKPHPRPEQK PITIPEVPESKPVPTT-------------------------------------------- ------------------------------------------------------------ ---------------------------------EHGPVTLRTQTWVTTKAPKTSKQTRRP RPKPKTTPS-------------------------------------------P------- -------------EAPLTKHVAATDLEPSALRTEEPATVVLATALEPVTLRTKAPETTTL AHKV-QRTR-------------RPRP--RPKTT-ASTDMSESKS---------------- ----------APTELQTLVLKPVTSPSLEMTQSQSVSDDLESVAFSTESPQKTI------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------RQTPRPPP---------------------- --------KFKTTPR------PRIP----------------------------------- --------------PQPP---------------------------------V-------- ---PRGS----------------------------------------------------- ------------------------------------------------------------ ----------------------QHITSKPKLP---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVMDT TS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDEQL-SHKTD----PEV-----SHSETV------------LPPVT FRTEPPKTT------------------------------------------IAP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPVISPRP- --SQEELQTVL------------------------------------------------- ------------------EETDQSTQELFTTKIPQTTEVAKTTR---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RVHTTPV-------------------- ------------------RPRIPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPH ARPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TKP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------GKTKPKVIPH----------------GNGAG T------------------------------------------------G---------- ------------------------------------------------------------ -----------TKQAPK------------------------------------------- -------------------------------------------------------PSSA- --------------GRNMSVD--------------------------------------- ---------------S-HA----------------------------T------------ ----KK-------P---------------------------------------------- ------------ATIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPSM---------PPRPMPP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------VSPQR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSSRATSPPPKATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPTGTAA-E----------- --------R---PETEK-KHPTT------------------------------------- ------------------------------------------------------------ -PS--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---IGTMTDFSSSPTKETDHLGKPRFVGPHVRY-IPK PDNRPCSITDSVRRFPT-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPIS---- A------GRDAIWTERPFN-S--DSYSDCKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSMOCP00000019924 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP SLKVHINTTSDSILLKFLRPNPSVKLEGFLLGYGSNVSPNQYFPLPTEGKVTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHRASTKAPEKTPF GGTILVHLIIPGLNDST-VKLPT-SIML-----------EISDALKAQLAKNETFTLAAE SKTPEVENVEAQ---------------------------------------PV------- --------TV-------------------------------------------------- ---TPETVSR---------SIKPTVSSALDTAETVL-DLSEKTP--AHSVLIPESELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRFP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KLD------------------------------ ------------------------------------------------------------ -----------------FPLE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPEDTLAS-SEEPW----------- -VAPGAKTSEDFKFVQ------------PQT----------------------------- ---------------------------------------------------------ETH D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------LISSSTTSDEMAK -EPH-TATSDPTLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTPRTPE----- -------------------------------------------------------QPKA- ----------------------------------T-------------------LASN-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-ASFDP--------------------------- ------------------------------------------------------------ ---------------------------QNVEVFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVQPTTT---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPTT--------------------------------------------------- ---PKRR-------------------------------PR--------PI---------- ------------------------------------------------TP---------- ------------------------------KVK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APKPE---------------TLPSAPST---------------------------- --------------------------------------K--------------------- ---------A-PPRTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------TTT------------------------------------------ -------------------------------------HSPE------------------- ------------------------------------------------------------ -------------------------------------TPE------------------SQ T---------ALEPA-------------------TVPSELLVPTIVPKPF------QRPK TT---------------------------------------------------------- -------CRPEV------------------------------------------------ -PKTQP------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------RQTPGTPH---------------------- --------KLKTTPP------PRIP----------------------------------- --------------PQPP---------------------------------V-------- ---PRGS----------------------------------------------------- ------------------------------------------------------------ ----------------------QHTISKPKMP---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVTDT KS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPTDEQL-SHKTD----PES-----SHSET------------------ ----------------------------------------------------AP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETLDISSTPVISPRP- --SQEELQTTW------------------------------------------------- ------------------EETDHFTQAIFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLHTTPV-------------------- ------------------RPRIPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPH ARPVQ------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TKP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------GKTKPKVIPH----------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------TKQAPK------------------------------------------- -------------------------------------------------------PSST- --------------GRNMSVD--------------------------------------- ---------------S-HA----------------------------T------------ ----KK-------P---------------------------------------------- ------------ATIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT------RPFI---------PPRPMPP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------RPPQR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSSRVTSPPLKATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPTGTAV-E----------- --------R---SEVEK-KHPTT------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---IGNTTDFSSSPTKETDHLGKPRFTGPHVRY-IPK PDNKPCSITDSVRRFPT-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASKTVAFSTESADPRVSEPIS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLASDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSPEMP00000035945 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNVSPNQYFPLPTEGKVTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRSRKPLQLVVGTLSPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVDNLKPNTVYEFGVKDNMDG--- GIWSKVFNH-----------------------------------------K--------- ------------------TVVG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHRASTKAPDKTPF GGTILVHLIIPGLNDSM-VKLPT-SIML-----------EISDALKAQLAKNETLALPAE SKTPEVEKVASQ---------------------------------------PV------- --------TV-------------------------------------------------- ---TPETVSR---------SIKSTVSSALDTSEPAL-ALNEKTPETAHSVLMPEFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRFP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------EAA------------------------------ ------------------------------------------------------------ -----------------FPLE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTLVS-SEDQW----------- -VAPGVKTSGDSKFVQ------------PPT----------------------------- ---------------------------------------------------------ATH D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VISSSTTSDETEI -EPH-TATSDPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTPE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-ASFDP--------------------------- ------------------------------------------------------------ ---------------------------HKVEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVQPTTA---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPTT--------------------------------------------------- ---SKRRF---------------------------RPKPP--------PI---------- ------------------------------------------------------------ -------------------------------IK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEPE---------------TLPSAKST---------------------------- --------------------------------------K--------------------- ---------A-PTKTK---------------------------------------RPGRL ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------VPE------------------SK P---------AREPA-------------------TVP---LVPTTVPKLS------QRPK AT---------------------------------------------------------- -------RRPEV------------------------------------------------ -PQIQPAYEQPATLG--------------------------------------------- ----------------------------------------------------TEAPALAI VTTTDIEPVITRTKAPATALA--------------------------------------- ----------------PKTP-QPRTH--R----------------PRPPIHKATPRPEI- --PQPKPELGPITPEPSLA--------------STTTKKA-----------RRRLRPKDK TIPHPE-------VPQTIL----------------------------VPATTLE------ ---------------PV-IRTEAPGMTLAPKLP--------------------QQP---- --------------------------------SHPHPKPKTTRSPTAPQTERVSTPVFEP VTPLKEDPVATIV---------------------------------------P------- -------------------ITDL------------------------------------- ----------------EPVTD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------LETPVAFRTEVPGTTLA-SKMS QRTRRPKPRP--T-ATMSPQAPQTKPVLPVALEPV-------------------TPRPEA PVTL-----------------------------APKTSKQKHHS-----------HSQQK HVTRPEVPKSKLVHTT------------------------ELE----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------PVTLRTETWVTTKAPKTTKRPRRP RLKPKTTPA-------------------------------------------P------- -------------KAPLTKPVAATDLEPSALRTEAPATVVLATALEPVTLRTKAPETTTL ASKV-HRTQ-------------RPHP--RPKTT-ASTDMSESKS---------------- ----------APTELQTLVLKPVTSPSLEMTHSQSVSDDRELVAFSTESPQKTI------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------V------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------RQTPGTPP---------------------- --------KLKTTPR------PRIP----------------------------------- --------------PQPP---------------------------------V-------- ---PKGS----------------------------------------------------- ------------------------------------------------------------ ----------------------QRTTSKPKTP---------------------------- ------------------------------------------------------------ ----------------------------------------------------PRPEGADT TS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDEQL-SHKTD----PEV-----SHTETV------------LPPVT FRAEPLKTT------------------------------------------IAP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRNIPFIPVISPRP- --SQEELQTAL------------------------------------------------- ------------------EETDRSTQELFTTKIPQTTEWAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLHTTPV-------------------- ------------------RPRILD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPH ARPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------GKTKPK--------------------GNGIG T------------------------------------------------G---------- ------------------------------------------------------------ -----------TKQAPK------------------------------------------- -------------------------------------------------------PPST- --------------GRNVSVD--------------------------------------- ---------------P-HA----------------------------T------------ ----KK-------P---------------------------------------------- ------------ATTP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRP--------------PMRP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------GP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------ISPQR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSSRVTSPPLKATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPTGTAA-E----------- --------R---PEAEK-KHPTT------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---IGNPTDFSSSPTKETDHLGKPRFTGPHVRY-IPK PDNRPCSITDSVRRFPT-EEA-IEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPIS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLASDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSMUGP00000015820 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSFALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP GLKVHINTTSDSILLKFLRPNPNTKLEGFLLGYGSNVSPNQFFPLPTEGKFTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRPRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RLYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNIEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPITIIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTPF GGTILVHLIIPGLNETT-VKLPT-SIML-----------EISDALKAQLAKNETLAPPAE SKTPEVEKVTTQ---------------------------------------PV------- --------TV-------------------------------------------------- ---TPETVSR---------STKPTLSSASDTAETEL-VVRQKTPETAHSVLTPEFESPLT TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRFP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTA------------------------------ ------------------------------------------------------------ -----------------FPLE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTLAS-SEEPW----------- -VAPGAKVPEDSRVGQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VISSSTTSDETEI -EPG-PATSDPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTPE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------Q-ASFDS--------------------------- ------------------------------------------------------------ ---------------------------QDVEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------ETQPTTA---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRQP---------------------------RPK---------------------- ------------------------------------------------------------ -------------------------------VK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APDLE---------------MRPSAQST---------------------------- --------------------------------------K--------------------- ---------A-PKKTK---------------------------------------RPGH- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RGPE------------------- ------------------------------------------------------------ -------------------------------------VRE------------------SK P---------ALEHT-------------------TVP-------TVPKPP------QRPT DT---------------------------------------------------------- -------RRPEV------------------------------------------------ -PQIQPASE-PVTFG--------------------------------------------- ----------------------------------------------------TKAPSLAI --------------------A--------------------------------------- ----------------PKVP-QPVTH--R----------------PRPK-HKATPSPKT- --PQTKPDLRPFTPEPSLA--------------STTKKA-------------RRPRPKPK STPHPG-------VPQTIL----------------------------VPATSLE------ ---------------PV-IRTEVPEMTLAPQLP--------------------QQP---- --------------------------------DYPHPKPKTTRSPTAPQTELVPTPVFEP VTPLKEDAVTTIV---------------------------------------P------- -------------------VTDL------------------------------------- ----------------EPVTD--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------LETLVTFRTEAPGTTLA-SKVS QRTRRPRPRP--K-ATLSPQAPQTKSVPAVVLEPV-------------------TLTSEA PVT--------------------------------------------------------- ------------------------------------------TIAPKRSQQKHRPRPKPK PIPSPEVPESKPVPTT-------------------------------------------- ------------------------------------------------------------ ---------------------------------ELEPVTLRTETWVTTK-PKPAKRTRRP RPKPKTTTT-------------------------------------------P------- -------------EAPLTKPVAATDLEPSALRTEVPATSVLATALELITLRTMAPETTTL ALKA-QRTH-------------RPRP--RPKTT-ASTDVSKSKP---------------- ----------APTELQTLVLKPVTSPSLEITEGQSVSDDLELVTLSTESPWKTI------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------RQTPGISP---------------------- --------RLRTTPR------PRTS----------------------------------- --------------AKLP---------------------------------V-------- ---PKEP----------------------------------------------------- ------------------------------------------------------------ ----------------------QHTPSKPKMP---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVADT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKGEQL-SHKAD----LEV-----SHSETV------------LPPVT FRVEPPKTT------------------------------------------IAP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRDIPLIPVISPRP- --SQEELQTVQ------------------------------------------------- ------------------EETDQSTQELFTTKIPRTTELPKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLHTTPV-------------------- ------------------RPKIPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------RPH ARPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -IKPRRP----------------------------------------------------- ------------------------------------------------------------ ---------------------------AN--------------------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------TKQAPK------------------------------------------- -------------------------------------------------------PSST- --------------GRNMTVS--------------------------------------- ---------------S-HA----------------------------T------------ ----KK-------P---------------------------------------------- ------------ATIS-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPM---------PPRPKPP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPQR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGRITSPPLKATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPIGTAT-E----------- --------R---PEAEK-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-EEE---FGNTTDFSSSPTKETDHLGKPRFVGPHVRY-IPK PDNRPCSITDSVRRFPT-EEA-LEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPIS---- A------GRDAIWTERPFN-S--DTYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSCCNP00000017756 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------K-RP SLKVHINTTSDSIFLKFLRPSPNTKLEGFLLGYGSNLSPNQYFPLPTEGKYTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKSRPRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIIG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PEYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------R------- -----------K---------------LIPVTIIKQ------------------------ -----------------------------------------VIQNITHKASTKSPDKTPF GGTVLVHLIIPGLNETT-VKLPT-SIML-----------EISDALKAQLAKNETLALPAE SKTPEAEKVPAQ---------------------------------------PI------- --------TV-------------------------------------------------- ---TPETVPR---------STKPTVSSALDISETTL-VLSGRTQETSQTILIPKFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTT------------------------------ ------------------------------------------------------------ -----------------FPVE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPGGTLAS-SGKPK----------- -MVPTAKASEDSRIVQ------------PQT----------------------------- ---------------------------------------------------------AIY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VFSSSTTSDEPEI -ESH-TATSDPILE---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRE- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-IPFSP--------------------------- ------------------------------------------------------------ ---------------------------LKVETFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EMQPTTS---------- -----------------------APQQ--------------------------------- ------------------------------------------------------------ --TTSVLST--------------------------------------------------- ---PKRRP---------------------------RPKP--------------------- -------------------------------------------------S---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APEPQ---------------SLLPAQST---------------------------- --------------------------------------K--------------------- ---------A-PPKTI---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------RSPE------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------ALEPT-------------------TVQMELLVPTIAPKPS------KTPQ IT---------------------------------------------------------- ----------DV------------------------------------------------ -PQIQP------------------------------------------------------ --------------------------------------------VFEPVTFKTDAPSINI VPTTDTEPVILRTKAPV-TLA--------------------------------------- ----------------PKITQRTRTR--R----------------PRPK-QKTTLSPKI- --PHTEPDFRPVTPGPPLAP--------------TTKRS-------------RRPRPKPK TTSHPE-------VPHTML----------------------------VPATILE------ ---------------PVILRTEAPGTTIALKVS--------------------QQP---- --------------------------------DRPHPKPKTTRSPEVPQTELVLTTVFEP VTPIKEAPGTSFVSVTD------------LETVTDF---------------EP------- -------------------VTTL------------------------------------- ----------------EPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LRTETSGATLA-TKTP QRTRRPRPRP--K-TTPSPQAPKTKPVPATVLEPV-------------------TLRPEA PGT--------------------------------------------------------- ------------------------------------------TLATQTSQQIRHPYPRPK PIPGPEA-ESKPVPTR-------------------------------------------- ------------------------------------------------------------ ---------------------------------QLESVTLRTETWVTTQAPKTSKRTRRP RPKPKTTPT-------------------------------------------P------- -------------EAPQTKLVPATNLEPGVLRTEAPEIVVLATVLEPVTVRTKAPE-TTL APKR-QRTR-------------RPRP--RPKTT-ASTGVSQTKS---------------- ----------APTELKTLLLKPVTSPSLDITQSQPVSDVLESVTFSMGSSKETI------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------RQTPRAPP---------------------- --------KPKTSSH------PRIP----------------------------------- --------------QTQP---------------------------------V-------- ---PKGS----------------------------------------------------- ------------------------------------------------------------ ----------------------QQATSKPKMS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSYP VP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VPKDVFL-PHKPD----PEV-----SQSEPV------------LQPVT FRIEPPKTT------------------------------------------IAP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPIISPSP- --SEEELQTIL------------------------------------------------- ------------------EETDQSTQGLFTTKIPRTTDLAKTTQ---------------- ------------------------------------------------------------ --------------------------------------ATH------------------- ---------------------------------RQYTTPA-------------------- ------------------RPRIPE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH FRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NRTT-------------------------------------- ------------------------------------------------------------ -TRL-------------------------------------------------------- ------------------------------------------------------------ -----------------------------IRPKPSGIPN----------------GNGVR T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPK------------------------------------------- -------------------------------------------------------PSGS- --------------GRNVSVDS-------------------------------------- ---------------T-HA----------------------------T------------ ----KK-------T---------------------------------------------- ------------VTIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GS-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------IPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SGGI-------------------------------------------- -----ISSDWVTSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPIGTPS-E----------- --------G---PEIDK-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LGNTTDFSSSPTRETDHLGKPRFKGPHVRY-IPK PDNKPCSITDSVKRFPT-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSFSG-KNK SIQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSEASP00005015855 ---------------------MFSQ----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LAC---------------------------------------------- ------------------------------------------------------------ ----------IVLHYFSPSV---------------------------------------- ----FSFP------------------------------PLG------------------- --------------------------------------------------------K-KP NLKVHINTTSDSIFLKFLRPNPNVKLEGFLLGYGSNLSPNQYFPLPAEGRHTEAVV--DA EPKYLIVVRPAPPPNRKKSCSGKARSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SQCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPDTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SK-------------------------- ----------------------KVNGKIQSTYDQAHSV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------VRTRLFSSMFSKNLIQNVTHRASAKSPDKTPY GGTILVHLVIPGLNETT-VKLPT-SIMF-----------EISDALKTQL----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GKQKIPAQRFLGCPRSLTNE--------- ---------------------------------------LVGDIKQPISVSSSSQKHLQQ IPFLFAV----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------AS-SEKPW----------- -IVPTTKTSEDSKVLP------------PR------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----TATSDPFLD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------L----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------G--------NVFN------ ------------------------------------------------------------ ---------------------------R-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------K----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------IILCFPSKENPCESCNLSFA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGSPFIPMISPSP- --SQEELLTAL------------------------------------------------- ------------------AETDQTTQELFTTKISRTTELAKTT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------P---------------------------------------------- ------------ATIP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSSRVTSPPLRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTEAPL-E----------- --------G---TETDK-KQPTV------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GED---LGNTTDFSSSPTRETDPLGKPRFKGPHVRY-IQK PDNRPCSITDSVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWDKPLN DTVT-E------------------------------------YEVIS-RENGTFSG-KNK SVQVTNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLDSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSOCUP00000004633 ---------------------MFSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------P--- --------S--------------------------------------------------- ---------------------------------------LG------------------- --------------------------------------------------------K-RP SLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNISPNQYFPLPAEGKYTEAVV--DA EPKYLIIVRPAPPPSQKKSCSGKTRPRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WVFQICPATETIVENLKPNTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKN------------------------- ----------------------KVNGKIQSTYDQIHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYVP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------K------- -----------K---------------LIPITVIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPERTPL GGTILVHLIIPGLNETA-VKLPM-SIML-----------EISDAIKAQLAKNETLALPAE SKTPEVEKIPAQ---------------------------------------PI------- --------TV-------------------------------------------------- ---TPETVPR---------TTKPTVSSALDLSETTL-VLSERTPEISQTILIPKFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PKRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPEA----------------------------------------- ------------------------------------------------------------ ---------------------------KTL------------------------------ ------------------------------------------------------------ -----------------FPFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KTEGSLAS-SETPW----------- -IVPTAKRSEDPKVPQ------------PQT----------------------------- ---------------------------------------------------------ATY D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AISSPTPSDEPEI AEPH-TATSEPILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIVSS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EGQPATS---------- -----------------------APQK--------------------------------- ------------------------------------------------------------ --TTSTPST--------------------------------------------------- ---HKRRP---------------------------RPKT--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------ERTTTSPGTITSKIPKKLEPTRTTLAPS----------KT------ ------------------------------------------------------------ --------------------QFISLKPKLPLSPEVIHTR--------------------- ---P---------------------------VLG-------------------------- PGTLG-----------TKP----------------------------------------- ---S-TTTLA-PPKTK---------------------------------------RPGR- ---------------------------R-------------------------------- ---------------PR----------------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ -------------------------------------PSPD------------------- ------------------------------------------------------------ -------------------------------------VPK------------------SK P---------AGEPA-------------------TVQPELLVPTV--------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------DSKLP----------------------KQFLP-KPKAP------ -----------PEPG--------------MPPTK---------PVFEPVTFETEAPSVTI VSTTDFEPVVLRTKAPITTLA--------------------------------------- ----------------PKTSQRARTR--R----------------PRPK-HKTTPSPEI- --PQPKPGYATITPETSLAP--------------TTKRA-------------RRPHPKPK TTPSPE-------ASQTKL----------------------------VPATILE------ ---------------PVILTTDAPGMTLAPKAP--------------------QRT---- --------------------------------RRPRPKPKPTPSPEAPRTELVPATVSEP VTPIKEAPGTAPVPITDLTPVTELAPVTALETVTDFGSVTV---------LVP------- -------------------VTDL------------------------------------- ----------------KPVT---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------FKTKTPGTTLA-TKIP QRTRRPRPRP--K-TTPSPQAPHTKLVPATVLEPV-------------------TLRPEA PRT--------------------------------------------------------- ------------------------------------------TLASKTSQRTRRPRPRPK TTPPPEAPESKPAPTV-------------------------------------------- ------------------------------------------------------------ ---------------------------------EFEPVTIQTETWVTTQAPKTPPRIRRP RPKPKATLS-------------------------------------------P------- -------------EIPETKPVVATDLEPSIPRTTAPETTVLATVLEPVTLRTEAPE-TTL APKT-QRTR-------------RPRP--RPKTTTSSPEVLQTK----LGF------EPVT HHTEVPGTTLAPTELQTLTLKPVTSPSLEMTQSQPVSDVLELVTFSTESSKETIAPSETD YVHPTAKAPFRPEEPKTE-AVDSITEVSEH-------------PAT---TVETSPLPSQT ITLP----------SPDEPQTE-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPRALP---------------------- --------KPKTSPR------PRIP----------------------------------- --------------QTQP---------------------------------A-------- ---PSGP----------------------------------------------------- ------------------------------------------------------------ ----------------------QRATLKPKLS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPEVSFT TP---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------VTKDVLL-PRKPE----PEV-----SQSEPV------------LQPVT FRIDLPKTT------------------------------------------IAP------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------LETRGIPFIPMISPSP- --SQEELLTTL------------------------------------------------- ------------------EETDQSTQELFTTKIPRTTELAKTTQ---------------- ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------RLYTTPV-------------------- ------------------RPRTPD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPH VKPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------DK---------------------------------------- ------------------------------------------------------------ -TRP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------ARPKPSGMPS----------------GNGVG T------------------------------------------------G---------- ------------------------------------------------------------ -----------VKQAPR------------------------------------------- -------------------------------------------------------PSAT- --------------GRNVTIDS-------------------------------------- ---------------T-HS----------------------------T------------ ----KK-------P---------------------------------------------- ------------APVP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GT-----RRPPL---------P-----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------LPPRR KPLPPN------------------------------------------------------ ----------------NVTGKPG------------------------------------- ------------SAGI-------------------------------------------- -----ISSGRETSPPPRATL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SPTGAPS-E----------- --------E---TDIDK-KQPTA------------------------------------- ------------------------------------------------------------ -PA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-GEE---LGNTTDFSSIPTRETDHSGKPRFKGPHVRY-IQK PDSRPCSITDSVKRFPT-EEA-TEGNATSPPLNPPTNLTVVTVE-GCPSFVILDWEKPLN DTVT-E------------------------------------YEVIS-RENGSISG-KNK SVQITNQTFSTVENLKPDTSYEFQVKPKNPLGEGPASNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLTSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSDNOP00000011429 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP SLKVHINTTSDSILLKFLRPNPNIKLEGFLLGYGSNVSPNQYFPLPADGKPTQAVV--DA EPKYLIVVRPAPTPSKKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RFYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPNTVYEFGVKDNIEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG----------SKN------------------------- ----------------------KVNGKIQSTYDQVHTV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PAYIP----------------------------------------- ------------------------------------------------------------ ----------------------------------------------------K------- -----------K---------------IIPITIIKQ------------------------ -----------------------------------------VIQNVTHRASTKSPDKTPL GGTILVHLIIPGHNETT-IKLPT-SIMF-----------DISDAIKTQLAKNETLALPAE SKTPGVEKIPGE---------------------------------------PI------- --------TV-------------------------------------------------- ---TPETVAR---------TTKPTASSALDISEAALVVLSERTRETLQTVLIPKFELPLS TL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------A----------- ------PYRLP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------EFPQA----------------------------------------- ------------------------------------------------------------ ---------------------------KTP------------------------------ ------------------------------------------------------------ -----------------FTFE--------------------------------------- ------------------------------------------------------------ -----------------------------------KPEGTWAS-SEKPW----------- -IVPTTKTFEDTKVLQ------------PQS----------------------------- ---------------------------------------------------------ETY DI---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------PSVFSSPSTPDEPEI AEPH-TATSDSILD---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SVP------ -----------------------------------------------PKTSRTLE----- -------------------------------------------------------QPRA- ----------------------------------T-------------------LAPS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-TPFVP--------------------------- ------------------------------------------------------------ ---------------------------QKLEIFTS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------S---------------QMQPTS----------- -----------------------AAQQ--------------------------------- ------------------------------------------------------------ --TTSIPST--------------------------------------------------- ---PKRRF---------------------------RPKS--------------------- -------------------------------------------------P---------- ------------------------------KTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- --------------AR-TTSPGTTTSKISETFEPEWTTLAPD----------KT------ ------------------------------------------------------------ --------------------QFISLKPKISHSPDVTHTK--------------------- ---P-----------------------------DSVERVLLPSRSIL------------G PGTLE-----------TKP----------------------------------------- ---S-TTTLV-PEKTK---------------------------------------RPGR- 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-----------AKPA--------------MPPTKF-------DTVFDPVTLETEVLSITI VPATDIEPVTLRTEAPGTTLA--------------------------------------- ----------------PKTSQRTRTR--R----------------PRPK-PKTTPGPKA- --PQTELDFERSTPETSLAP-------------TTTKRT-------------RHPHPKPK TTSQPE-------VPQIKL----------------------------VPPTILE------ ---------------RVTLRTEAPGTTLAPKIP--------------------QRT---- --------------------------------RRPRPKPKTTLSPDAPQTIVSPATVLEP V---------------------------------------GTLQEITRITLVP------- -------------------VTDL------------------------------------- ----------------EHVTLR-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --TETSGTTLVLSPSLIPPPPRQLPALCPFAKGPLYFPL--------------------- --------------------------VPAIVLEPI-------------------TLRPEA PGTTLGNVLPSTSKRLQTHHPRPKILPNPEVSVY-------------------------- ------------------------------------------------------------ ----------KPIPTADLEPVIPGTEVPVTTRGEFKKTSLLTQEKKTLLSATPIYELKER KLVPVTDLEPVTLRTEAPETMVLTTVLETVIRTTMALE---------------------- ----------------------------------------------TTLAPKTSQRTRRP RPRPKTTPS-------------------------------------------P------- -------------HVPQSKPVPATD----------------------------------- -------------------------------------------------F------EPVI YSTEAPGTTLAPTELQTLILKPMTSPSLEIPQSQHVANVLEPSTLSTESSRKSLAPAETH YVYLTAKAPLRPDEPKTEAVVESITNVSEP-------------PEA---TLETSPLPSKT IILP----------SPDEPAAK-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KQTPHAPP---------------------- --------KPKTSPR------PRIP----------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ -----------WGCLLLCGSIALAL----------------------------------- ----------------------------------------GNAQKL----------P--- --------K--------------------------------------------------- ----------------------------------------G------------------- --------------------------------------------------------K-RP NLKVHINTTSDSILLKFLRPSPNVKLEGFLLGYGSNLSPNQYFPLPAEGKYTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKKRPRKPLQLVVGTLSPSSVFLSWGFLINPHHD-WTLP SQCPND-RYYTIRYR--EKDKEKK-WIFQLCPATETIVENLKPDTVYEFGVKDNVEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TIVG-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------TSFCFL TDFCLFVCLFPFTLLSF------------------------VIQNVTHRASTKSPDKTPY GGTIVVHLVIPGLNETT-VKLPT-SIMF-----------EISEAIKTQLAKNETLALPAE SKTPEVEKIPAL---------------------------------------PI------- --------TV-------------------------------------------------- ---TPESVPR---------TTKPTVSSALDISETTL------------------------ 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DTVT-EHKCIQHHGDFKTQLGGTLSMTRCCFLLLKNVVLFFSF----------------- -------------------SYEFQVKPKNPLGEGPPSNTVAFSTESADPRVSEPVS---- A------GRDAIWTERPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQLSSDQLPTKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSUMAP00000003080 ---------------------MLSS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------NKASSTSPLL---QICSGMLTGKITALY------------- ----FVFP------------------------------SLG------------------- --------------------------------------------------------K-RP SLKVHINTTSDSILLKFLRPNPNVKLEGFLLGYGSNLSPNQYFPLPAEGKFTEAVV--DA EPKYLIVVRPAPPPSQKKSCSGKARSRKPLQLVVGTLTPSSVFLSWGFLINPHHD-WTLP SHCPND-RYYTIRYR--EKDKEKK-WVFQLCPATETIVENLKPNTVYEFGVKDNGEG--- GIWSKIFNH-----------------------------------------K--------- ------------------TVVG----------SK-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------CLHITAIYCFLT--VTFC-- --------------IST------------------------VIQNVTHRASTKSPDKTPF GGTIVVHLIIPGLNETT-VKLPA-SIML-----------EISDAIKTQLAKNETLALPAE SKTPEVEKIPAK---------------------------------------PI------- --------TV-------------------------------------------------- ---TPESVPR---------TTKPTVSSALDFSEKTL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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----------------ALSPLTRFNKNISNLFVLHFIV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---VL------------------------------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PASHEIESVSSESQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------TP-----------------------------V PKGT-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------W----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ---------------KLVPNS--------------------------------------- ------------------------------------------------------------ -------------------------------------------QTQIILSDNK------- -----------K---------------LVPVTIIKQ------------------------ -----------------------------------------IIQN---RTQSKAPDSSSL PGAILVHLIVPGLNESQ-QKLP-----------PLLTIDDIPQASRKKLAKNETGVWPAE SKTPEVQEISPQ---------------------------------SL----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ---QAEKTHGPEDFKSTPKPKLVQTQNIP------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VTSSADLEKPLSPLSRAPQVLTTTAVFSGIQP-VLSSPVSPSKPEM AETGPAA-SESILE---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SFT------ -----------------------------------------------PKTSHPFQ----- -------------------------------------------------------WPRV- ----------------------------------T-------------------LAPK-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-IPLIP--------------------------- ------------------------------------------------------------ ---------------------------SKPKPSAT------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------GVQRV-------KPAPK PPLLE---PKTSETVEQPKATL-APKEAK------------------------------- -----------------------------------LTT---------------------- -SAKLTTSAS-------------------------------------------------- --KPRPSA---------------------------RPQK--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------AA----------------MPGSGTS---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------R-------------------------------- --------------SPY---------------------------TSER---A-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------EV--------------- -----LDPITLRIEPPRSPIA--------------------------------------- ----------------PKVT-------QR------------------------------- ------------------------------------------------------------ -----------------------------------------------VP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------S----------------------------------------- --KPKTSPK-------------------------------------------P------- -------------HIPQAKDV-----------------------LESITLRTDQLK-PTL VPRGPQYFPS-------------------------------------------------- --------------------KPRTSPS--------------------------------- ------------------------------------------------------------ ---------------PEVPRTR-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------S------------------------------------------------- ------------------------------KDTYHRPS---------------------- --------KPKTSPS------PRVP----------------------------------- --------------PTRA---------------------------------S-------- ---PKES----------------------------------------------------- ------------------------------------------------------------ ----------------------RRVPSKPRAS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPDVPHT KP-----------------ALKEPQHIPFKP------------------------RATPM PDAP-------------YRKPEIF-----------PSFDEEDTTVIPHIPERT------- --KATFAP----------------TEKQFIHTKQKTTERPRVPYTRLAIYPTTPQPIVTK SS-TTGPSRATMAPKETLLIPSKSKTSVGPEV-----PQTKPA----------------- -----PRATHLGSINLVTVHVVDGSKIT-----------------------LVP------ ------------------------------------------------------------ -NETYH------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ISPRP- ------------KIGQATEIPWFDT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------KTRLTSA-------------------- ------------------RPRPSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPQ TRPAF------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------SKTT-------------------------------------- ------------------------------------------------------------ -LAP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------ARTKAPALPKWIVPTT--DDLYTPEA----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------T------------ ----AR-------PI-------------------------------------DMGVKRPP EYFDTWQKPISVTIPP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GP-----QHPPI---------P-----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TQMRR KPLPPN------------------------------------------------------ ----------------TVTGKPG------------------------------------- ------------SP---------------------------------------------- -------------------A---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPAGPTPPV----------- --------R---TGTLY-KTPTA------------------------------------- ------------------------------------------------------------ -FA--------------------------------------------------------- ------------------------------------------------------------ ------------------T-PEY---YVDETVFSSSPTSETDSSGKPRYQAPHVKY-MKK DDDVPCSITSSLEHFPQ-EEVGSKEEPTRPPQNPPTNLTVVTVE-GCPSFVILDWEKPDN DTVT-E------------------------------------YEVVS-TENGGSDGEKEK SIITTNQTHSTVENLKPDTSYEFHVKPRNPLGEGPSSNVVAFSTESADPRVSEPIS---- M------GKDAIWTEIPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQ---EDLPVKDGFFRAVRQEPVKFGKIGGETQINYVRWYECGTSIPG KW >ENSPMJP00000014717 ---------------------MMSR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------FVCLLFCGYIALNL----------------------------------- ----------------------------------------GNTQKL----------P--- --------R--------------------------------------------------- ----------------------------------------V------------------- --------------------------------------------------------K-RQ SLKVQINATDDTVCMRYLRPSQSTKLEGFVLGYGSNFFSNQYIPLPSEGKNYITEL--DA EPRYLVSVRPARISNNKKSCSGRNKTQKPLQLVVGTLSPTSVFLSWGILVNPQHD-WTAT SNCASD-RFYTVRYR--EKGKDKK-WVFQLCPATETVIDNLKPNTPYEFGVKDNAED--- SIWSKTLNH-----------------------------------------K--------- ------------------TVLS----------SK-------------------------- ----------------------KVNGQIQNMY---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KLVPNS--------------------------------------- ------------------------------------------------------------ -------------------------------------------QTQIIFSDNK------- -----------K---------------LVPVTIIKQ------------------------ -----------------------------------------IIQN---RTQSKAPDSSSL PGAILVHLIVPGLNESQ-QKLP-----------PLLTIDDIPQASRKKLAKNETGVWPAE SKTPEVQEISPQ---------------------------------SL----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ---QAEKTHGPEDFKSTPKPKLVQTQNIP------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------S----------------------------------------- --KPKTSPK-------------------------------------------P------- -------------HIPQAKDV-----------------------LESITLRTDQLK-PTI VPREPQRVPS-------------------------------------------------- --------------------KPRTSPS--------------------------------- ------------------------------------------------------------ ---------------PEVPRTK-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------S------------------------------------------------- ------------------------------KDTYHRPS---------------------- --------KPKTSPS------PRVP----------------------------------- --------------PTRA---------------------------------S-------- ---PKES----------------------------------------------------- ------------------------------------------------------------ ----------------------RRVPYRPRAS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPDVPHT KP-----------------ARKEPQHIPFKP------------------------RATPI PDAP-------------YRKPEIL-----------PTFDERDATMIPHIPDRT------- --KAPFAP----------------TEKPFIHTKRKTTERPRVPYTKPAIYPTTPQPIITK SSPTTGRSRATMAPKETLLIPSKSKTSVGPEV-----PQTKPA----------------- -----PRATHLGSINLVTVHVVDGSKIT-----------------------LVP------ ------------------------------------------------------------ -NETYH------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ISPRP- ------------KIGQATEIPWFHT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------KTRLTSA-------------------- ------------------RPKPSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KSQ TRPAF------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------TKTT-------------------------------------- ------------------------------------------------------------ -LAP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------ARTKAPGLPKWIVPTT--DYLYTPEA----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------T------------ ----AR-------PI-------------------------------------DIDVKRPP EHFDPWQKPISVTSSP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GP-----QHPPL---------P-----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TQMRR KPLPPN------------------------------------------------------ ----------------TVTGKPG------------------------------------- ------------SP---------------------------------------------- -------------------A---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPAGPTPPV----------- --------R---TGTLY-KTPTA------------------------------------- ------------------------------------------------------------ -FA--------------------------------------------------------- ------------------------------------------------------------ ------------------T-PEY---YVDETVFSSSPTSETDSSGKPRYQAPHVKY-MKK DDDVPCSITSSLEHFPQ-EEVGSKEEPTRPPQNPPTNLTVVTVE-GCPSFVILDWEKPDN DTVT-E------------------------------------YEVVS-TENGGSDGEKEK SIITTNQTHSTVENLKPDTSYEFHVKPRNPLGEGPSSNVVAFSTESADPRVSEPIS---- M------GKDAIWTEIPFN-S--DTYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQ---EDLPVKDGFFRAVRQEPVKFGKIGGETQINYVRWYECGTSIPG KW >ENSSCAP00000023386 ---------------------MMSR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------FVCLLFCGYIALNL----------------------------------- ----------------------------------------GNTQKL----------P--- --------R--------------------------------------------------- ----------------------------------------V------------------- --------------------------------------------------------K-RQ SLKVQINATDDTVCMRYLRPSQSTKLEGFVLGYGSNFFSNQYIPLPSEGKNSVTEL--DA EPRYLVSVRPARVSNNKKSCSGRNKTQKPLQLVVGTLTPTSVFLSWGILVNPQHD-WTAT SNCASD-RFYTVRYR--EKGKDKK-WVFQLCPATETVIDNLKPNTPYEFGVKDNAED--- SVWSKTLNH-----------------------------------------K--------- ------------------TVLS----------SK-------------------------- ----------------------KVNGQLQNMY---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KLVPNS--------------------------------------- ------------------------------------------------------------ -------------------------------------------QTQIILSDNK------- -----------K---------------LVPVTIIKQ------------------------ -----------------------------------------IIQN---RTQSKAPDSSSL PGAILVHLIVPGLNESQ-QKLP-----------PLLTIDDIPQASRKKLAKNETGVWPAE SKTPEVQEISPQ---------------------------------SL----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ---QAEKTHGPEDFRSTPKPKLVQTQNLPASNEIQLLPSGSRIPDAPKSPLTEFATQSPA LKSVSLPSAEKREMEM-------------------------------------------- ------------------------------------------------------------ -----AFEEKQTVSLGSKPSSTMEVQPTRPASHDFLHVISTPQTF--------------- ---------------------------------------TSSEI--PATDLGERKPLSSR VTTSGIPEMPPIS----------------------------------------------- ----------------------------------------------AATQRPHL------ ---------------------------------------------------EWT------ -----------------SSAPRETTRKAAQ-------------------RPRPKSTTPSS LATQQTVMA--------------------------------------------------- ------------------------SLDSNH-----------------------------I S----------------------------------------------------------- ------------------------------------------------------------ ---------------FLSQTSAS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------AEI--------SKT----------------------- --------------------------------E--------------------------- -------------TVTSSADLEKPMPPFSRTPHVLTTTAVFSGIQP-VLSSPGAPSKPEI PDAGPAATSEFILE---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SFT------ -----------------------------------------------PKTSHPFQ----- -------------------------------------------------------WPRV- ----------------------------------T-------------------LAPK-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-KPLIP--------------------------- ------------------------------------------------------------ ---------------------------SKLKPSAS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EAHHV-------KPAPK PPLLE---PKTSETVEQPKATL-APKE--------------------------------- ------------------------------------------------------------ --AKLTTSAS-------------------------------------------------- --KPRPSA---------------------------RPQK--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------AT----------------IPVSVTS---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------R-------------------------------- --------------SPY---------------------------TYEH---P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------EV--------------- -----LEPIALRTEPPRSPLA--------------------------------------- ----------------PKAT-------QR------------------------------- ------------------------------------------------------------ -----------------------------------------------VP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------S----------------------------------------- --KPKTSPK-------------------------------------------P------- -------------HVPQAKDV-----------------------LESITLRTDQLK-PTI VPRGPQYVPS-------------------------------------------------- --------------------KPRSSPS--------------------------------- ------------------------------------------------------------ ---------------PEVPRTR-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------S------------------------------------------------- ------------------------------KDTYHRPS---------------------- --------KPRTSPS------PRVP----------------------------------- --------------PTRA---------------------------------S-------- ---PKES----------------------------------------------------- ------------------------------------------------------------ ----------------------RRVPSKPRAS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPDVPHT KP-----------------ALKEPQHIPFKP------------------------RATPI PDAP-------------YRKPEIL-----------PTFDEPDTTMIPHIPERT------- --KAIFAP----------------TEKQFIHTKRKTTERPRVPYTKHAIYPTTPQPIVTK SSTTTGHSRPTMAPKETLIIPSKSKTSVGPEV-----PQTKP------------------ ----------------------------------------------------VP------ ------------------------------------------------------------ -SETYH------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ISPRP- ------------KIGQATEIPWFNT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------KTRLTSA-------------------- ------------------RPQPTD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KSQ TRPAF------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------S---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------KTT------------------------------LAPV------- ---------------RTK---------------------------------APGLPKW-- -----------------------I------------------------------------ --------------MP-TTDD------------FYTPED------LYT------------ ----AR-------PI-------------------------------------DMDVKRPP EYVDTWQKPISVTIPP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GP-----QHPPI---------P-----PV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TQMRR KPLPPN------------------------------------------------------ ----------------TVTGKPG------------------------------------- ------------SP---------------------------------------------- -------------------A---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPAGPTPPV----------- --------R---TGTLY-KTPTA------------------------------------- ------------------------------------------------------------ -FA--------------------------------------------------------- ------------------------------------------------------------ ------------------T-PEY---YVDATVFSSSPTSETDSSGKPRYQAPHVKY-MKK DDDVPCSITSSLEHFPQ-EEVGSKEEPTRPPQNPPTNLTVVTVE-GCPSFVILDWEKPDN DTVT-E------------------------------------YEVVS-TENGGSDGEKEK SIITTNQTHSTVENLKPDTSYEFHVKPRNPLGEGPSSNVVAFSTESADPRVSEPIS---- M------GKDAIWTEIPFN-S--DTYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQ---EDLPVKDGFFRAVRQEPVKFGKIGGETQINYVRWYECGTSIPG KW >ENSCCEP00000016901 ---------------------MMSR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------FVCLLFCGYIALNL----------------------------------- ----------------------------------------GNTQKL----------P--- --------R--------------------------------------------------- ----------------------------------------V------------------- --------------------------------------------------------K-RQ SLKVQINATDDTVCMRYLRPSQSTKLEGFVLGYGSNFFSNQYIPLPSEGKNYITEL--DA EPRYLVSVRPARVSNNKKSCSGRNKTQKPLQLVVGTLTPTSVFLSWGILVNPQHD-WTAT SNCASD-RFYTVRYR--EKGKDKK-WVFQLCPATETVIDNLKPNTPYEFGVKDNAED--- SIWSKTLNH-----------------------------------------K--------- ------------------TVLS----------SK-------------------------- ----------------------KVNGQIQNMY---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KLVPNS--------------------------------------- ------------------------------------------------------------ -------------------------------------------QTQIIFSDNK------- -----------K---------------LVPVTIIKQ------------------------ -----------------------------------------IIQN---RTQSKAPDSSSL PGAILVHLIVPGLNESQ-QKLP-----------PLLTIDDIPQASRKKLAKNETGVWPAE SKTPEVQEISPQ---------------------------------SL----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ---QAEKTHGPEDFKSTPKPKLVQTQNIPASNEIQLLPSGSRIPDAPKSPLTE------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------S----------------------------------------- --KPKTPPK-------------------------------------------P------- -------------HIPQAKDV-----------------------LESITLRTDQLK-PTI VPREPQRVPS-------------------------------------------------- --------------------KPRTSPS--------------------------------- ------------------------------------------------------------ ---------------PEVPRTK-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------S------------------------------------------------- ------------------------------KDTYHRPS---------------------- --------KPKTSPS------PRVP----------------------------------- --------------PTRA---------------------------------S-------- ---PKES----------------------------------------------------- ------------------------------------------------------------ ----------------------RRVPSRPRAS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPDVPHT KP-----------------ARKEPQHIPYKP------------------------RATPI PDAP-------------YRKPEIL-----------PTFDERDATMIPHIPDRT------- --KAPFAP----------------TEKPFIHTKRKTTERPRVPYTKPAIYPTTPQPIITK SSTTTGHSRATMAPKETLLIPSKSKTSVGPEA-----PQTKP------------------ ----------------------------------------------------VP------ ------------------------------------------------------------ -DETYR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ISPRP- ------------KIGQATEIPWFHT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------KTRLTSA-------------------- ------------------RPKPSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KSQ TRPAF------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------IKTT-------------------------------------- ------------------------------------------------------------ -PAP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------ARTKAAGL-----PTT--DYFYTPEA----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------T------------ ----AR-------PI-------------------------------------DMGVKRPP EHFDTWQKPISVTSSP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GP-----QHPPI---------P-----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TQMRR KPLPPN------------------------------------------------------ ----------------TVTGKPG------------------------------------- ------------SP---------------------------------------------- -------------------A---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPAGPTPPV----------- --------R---TGTLY-KTPTA------------------------------------- ------------------------------------------------------------ -FA--------------------------------------------------------- ------------------------------------------------------------ ------------------T-PEY---YVDETVFSSSPTSETDSSGKPRYQAPHVKY-MKK DDDVPCSITSSLEHFPQ-EEVGSKEEPTRPPQNPPTNLTVVTVE-GCPSFVILDWEKPDN DTVT-E------------------------------------YEVVS-TENGGSDGEKEK SIITTNQTHSTVENLKPDTSYEFHVKPRNPLGEGPSSNVVAFSTESADPRVSEPIS---- M------GKDAIWTEIPFN-S--DTYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQ---EDLPVKDGFFRAVRQEPVKFGKIGGETQINYVRWYECGTSIPG KW >ENSMVIP00005015442 ---------------------MMSR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LVCLLFCGYIALNL----------------------------------- ----------------------------------------GNAQKL----------P--- --------R--------------------------------------------------- ----------------------------------------V------------------- --------------------------------------------------------K-RQ SLKVQINATDDTVCMRYLRPSQNTKLEGFVLGYGSNFFSNQYIPLPSDGKNYVTEL--DA EPRYLVSVRPARVS-NKKSCSGRTKTQKPLQLVVGTLTPTSVFLSWGILVNPQHD-WTAT SNCASD-RFYTVRYR--EKGKDKK-WVFQLCPVTETVIDNLKPNTQYEFGVKDNVED--- SIWSKTLNH-----------------------------------------K--------- ------------------TVLS----------NK-------------------------- ----------------------KVNGQFQNMY---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KLVPNS--------------------------------------- ------------------------------------------------------------ -------------------------------------------QTQLILSDNK------- -----------K---------------LVPVTIIKQ------------------------ -----------------------------------------VIQN---RTQPKTPDSSSL PGAILVHLIVPGLNESQ-QKLS-----------PLLTIDGLSPASRKKLAQNETGIWPAE SKTPEVQEISPQ---------------------------------SL----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ---QAEKTHGPEEFKSTPKPKLVQTQNIPASNDIQLLPSGSRISDAPKTPLTDRATQSPA LKPITLPSAEAREMEM-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ -----------------------------------------------VP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------S----------------------------------------- --KPKTSPK-------------------------------------------P------- -------------HIPQAKDV-----------------------LESITFRTDQLK-PTI VPKEPHRVPS-------------------------------------------------- --------------------KPRTSPSSEMSQTKPV---LEPIKFRTEKPKSTIAPKDT- -----------------------------------------------R------------ ---P----------G--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------PS---------------------- --------KPKTSPS------PRVP----------------------------------- --------------PTRA---------------------------------S-------- ---PKES----------------------------------------------------- ------------------------------------------------------------ ----------------------RRVPSKPRAS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PAPDVPHT KP-----------------ASKEPQYIPFKP------------------------KATPI PDAP-------------HRKPEIF-----------PTFGEPDTTMIPRIPERT------- --KATLAP----------------TEKQFIHTRPKTTEKSRVPHTKPAIHQTTPQPIITK SSTTTGHSKATMAPKETLLIPSKPKTSVWPEV-----PQTKP------------------ ----------------------------------------------------VP------ ------------------------------------------------------------ -NETYH------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ISPKP- ------------KIAQATEIPWFNT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------KTRLPSA-------------------- ------------------RPKPSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KSQ TRPVF------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------SKTT-------------------------------------- ------------------------------------------------------------ -LAP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------ARTKAPGLPQWIAPTT--GDMYIPE------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------DITEQVAV-------------- ------------------------------------------------------DVKKPW EYIDTWEKPLSVTTSP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GP-----QRPPI---------P-----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TQMRR KPLPPN------------------------------------------------------ ----------------TVTGKPG------------------------------------- ------------IP---------------------------------------------- -------------------A---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPAGPTLPV----------- --------R---TGTSY-RTPTA------------------------------------- ------------------------------------------------------------ -FA--------------------------------------------------------- ------------------------------------------------------------ ------------------T-PEY---YVDATVFSSSPTSETDSSGKPRYQAPHVKY-MKK DDDVPCSITSSLEHFPQ-EEAGSKEEPTRPPQNPPTNLTVVTVE-GCPTFVILDWEKPDN DTVT-E------------------------------------YEVVS-TENGGSDGEKEK SIITTNQTHSTVENLKPDTSYEFHVKPRNPLGEGPSSNVVSFSTESADPRVSEPIS---- M------GKDAIWTEIPFN-S--DTYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQ---EDLPVKDGFFRAVRQEPVKFGKIGGETQINYVRWYECGTSIPG KW >ENSCPGP00000009510 ---------------------MMSR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LVFLLFCGYIALNL----------------------------------- 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KLVPNA--------------------------------------- ------------------------------------------------------------ -------------------------------------------QTQLTLRDNK------- -----------K---------------LVPVTIIKQ------------------------ -----------------------------------------VIQN---RTQSKTSDSSSL PGAILVHLIVPGLNETQ-QKLP-----------PLLTIDDIPQASRKKIAKNETQVWPAE SKTPEVQEISPQ---------------------------------SL----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ---QAEKKHGPEEYKSTPKPELVQTQNILASNEIQPLPSGSRISDAPKSPLTELATQRPA LKSISLPSAETREMEM-------------------------------------------- ------------------------------------------------------------ -----AFEETQPVSSGSKTSGTTEVQPTR------------------------------- ------------------------------------------------SDLGERKPLSSR STTSGMPEMPPIS----------------------------------------------- ----------------------------------------------AASQRP-------- ------------------------------------------------------------ -----------------------------DLESTSSASLETTRTVMATRRPRLKSTTPSS LATQQTVM---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------VTSSTDLEKSMPPLCRTPHVLTTTMDFSGIQP-VLSSPVTPSKPEI AAAEPAT-SEFILE---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SFT------ -----------------------------------------------SKTSRPFQ----- -------------------------------------------------------WPRV- ----------------------------------T-------------------LAPK-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-IPLIP--------------------------- ------------------------------------------------------------ ---------------------------SKLKPSAS------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVQHV-------KPAPK PPLLE---PKTSQTVEQPKATL-APNE--------------------------------- ------------------------------------------------------------ --AKLKPSAS-------------------------------------------------- --KRRPSA---------------------------RPKK--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------P--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------AA---------------TIPVSVTA---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------K-------------------------------- --------------SPY---------------------------AYEH---P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTT------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------EV--------------- -----LEPITLRIEPPRPTIA--------------------------------------- ----------------PKET-------QR------------------------------- ------------------------------------------------------------ -----------------------------------------------IP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------S----------------------------------------- --KPKTSPK-------------------------------------------P------- -------------HIPQTKD---------------------------------------- VPKETQRVPS-------------------------------------------------- --------------------KPRTSPS--------------------------------- ------------------------------------------------------------ ---------------SEVPQTK-PVL---------------------------------- --------------------------------------------------------EPIT F------------------------------------RTEKPKSTVA------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KDTRHGPS---------------------- --------KPKTPPS------PRVP----------------------------------- --------------PTRA---------------------------------S-------- ---PKES----------------------------------------------------- ------------------------------------------------------------ ----------------------RRVSSKPRAS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPDVPHT KP-----------------APKEPQHTPFKP------------------------KAPPI PDAP-------------RSKPEII-----------PTFHEPDTTMIPHIPERT------- --KATLAP----------------TEKQFIHTKSKTSEKSRLPHTKPAIHQTTPQPIITK SSTITEH-WATMAPKETLLIPSKTKTSVGPEV-----PQTKPA----------------- -----PRATHLGSINLITVHVVDGSKMT-----------------------LVP------ ------------------------------------------------------------ -NETYQ------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ISPKP- ------------KAALATETPQFST----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------KTRLTSA-------------------- ------------------RPKPSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KSQ IRPAL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------SKTT-------------------------------------- ------------------------------------------------------------ -PAP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------PRTKAPGLPKWIVPTT--DEVYTPE------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------DIAGQISMDMEKVL-------------------------- ------------------------------------------------------------ EYSDTWEKPFSVTTSP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GP-----QHPPL---------P-----PV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TQMRR RPLPPN------------------------------------------------------ ----------------TVTGKPG------------------------------------- ------------SP---------------------------------------------- -------------------A---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPAGPTTPV----------- --------R---TGTSY-KSPTA------------------------------------- ------------------------------------------------------------ -FA--------------------------------------------------------- ------------------------------------------------------------ ------------------T-PEY---YVDATVFSSSPTSETDSSGKPRYQAPHVKY-MKK DDDVPCSITSSLEHFPQ-EEAGSKEEPTRPPQNPPTNLTVVTVE-GCPTFVILDWEKPDN DTVT-E------------------------------------YEVVS-TENGASDGEKEK SIITTNQTHSTVENLKPDTSYEFHVKPRNPLGEGPSSNVVTFSTESADPRVSEPIS---- M------GKDAIWTEIPFN-S--DTYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQ---EDLPVKDGFFRAVRQEPVKFGKIGGETHINYVRWYECGTSIPG KW >ENSNMEP00000020098 ---------------------MMPR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LVLLLFCGYIAVNL----------------------------------- ----------------------------------------GSAQKL----------P--- --------R--------------------------------------------------- ----------------------------------------V------------------- --------------------------------------------------------K-RQ SLKVQINATDDTVCMRYLRPSQNTKLEGFVLGYGSSFFSNQYIPLPSEGNTYINEL--DA EPRYLVSVRPARVSNNKKSCSGRNKNQKPLQLVVGTLTPTSVFLSWGILVNPQHD-WTAT SNCASD-RFYTVRYR--EKDKDKK-WVFQLCPVTETVVDNLKPNTLYEFGVKDNMED--- SIWSKTFNH-----------------------------------------K--------- ------------------TVLS----------NK-------------------------- ----------------------KVNGQFQNMY---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KLVPNT--------------------------------------- ------------------------------------------------------------ -------------------------------------------QSQLTLRDNK------- -----------K---------------LVPVTIIKQ------------------------ -----------------------------------------VIQN---RTQSKTSDSSSL PGAILVHLIVPGLNETQ-QKLL-----------PPLSIDDITQVSRKKLGKNETQVWPAE SKTPEVQEISPQ---------------------------------SL----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ---QVEKKHGPKEFKSTPKPEL-QTQSIL------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KSQ ARPAL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------SKTT-------------------------------------- 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----------------------------------------V------------------- --------------------------------------------------------K-RQ SLKVQINATDDTVCMRYLRPSQNTKLEGFVLGYGSSFFSNQYIPLPSEGNTYITEL--DA EPRYLVSVRPARVSNNKKSCSGRTKTQKPLQLVVGTLTPTSVFLSWGILVNPQHD-WTAT SNCASD-RFYTVRYR--EKDKDKK-WVFQLCPVTETVVDNLKPNTVYEFGVKDNVED--- SIWSKTFNH-----------------------------------------K--------- ------------------TVLS----------NK-------------------------- ----------------------KVNGHLQNMY---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KLVPNT--------------------------------------- ------------------------------------------------------------ -------------------------------------------QTQLTLRDNK------- -----------K---------------LVPVTIIKQ------------------------ -----------------------------------------VIQN---RTQSKTSDSSSL PGAILVHLIVPGLNETQ-QKLF-----------PPLTIDDIPQASRKKLAKNETHVWPAE SKTPEVQEISPE---------------------------------SL----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ---QAERKHGPKEFKSTPKPEL-QTQNILA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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----------------------------------------FNDIQP-VLSSLVTPSKPEI ADTEPAT-IESILE---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SFT------ -----------------------------------------------PKTYHPFQ----- -------------------------------------------------------WPRV- ----------------------------------T-------------------LAPK-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-IPLTP--------------------------- ------------------------------------------------------------ ---------------------------PKPKPSAT------------------------- ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------S----------------------------------------- --KPKTSPK-------------------------------------------L------- -------------PIPHAKDV-----------------------LESVTLRTARQK-PTI VPKETHRIPS-------------------------------------------------- --------------------KPRTSPS--------------------------------- ------------------------------------------------------------ ---------------SEVPQTK-PVL---------------------------------- --------------------------------------------------------EPIT F------------------------------------RTEKPKSTAA------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------RETHHGPS---------------------- --------KPKTSPS------PRVP----------------------------------- --------------PTRA---------------------------------S-------- ---PKES----------------------------------------------------- ------------------------------------------------------------ ----------------------RRVTFKPRTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPDVPHT KP-----------------APKEPQHIPFKP------------------------KPAPI PDVP-------------HGKPGIF-----------PSFHEPVTAMIPHIPERT------- --KATPAP----------------SEKQFIHTKPKKPEKPRAPHTKPAIHQTTPQPLITK -STTTEQSRATMAPKETLLIPSKPKTSVEPEI-----PQTKPA----------------- -----PRTTHLGSINLITVHVVDGSKMT-----------------------LVP------ ------------------------------------------------------------ -NETYQ------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ISPKP- ------------KTAFVTEIPRLNT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------AAY------------------- ---------------------------------KTRLTSA-------------------- ------------------RPKPSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KSQ TRHAL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------SKTT-------------------------------------- ------------------------------------------------------------ -LAP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------ARTKSPGLPKWIVPTT--DDVYTPA------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------DVTRQIGV-------------- ------------------------------------------------------DVEKPF EYSDTREKPFYVTTSP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------RP-----QRPPI---------P-----PV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPMRR KPLPPN------------------------------------------------------ ----------------TVTGKPG------------------------------------- ------------SP---------------------------------------------- -------------------A---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPAGPTTPV----------- --------R---TGIPS-KTPTA------------------------------------- ------------------------------------------------------------ -FA--------------------------------------------------------- ------------------------------------------------------------ ------------------T-PEY---YVDATVFSSSPTSETDSSGKPRYQAPHVKY-MKK DDDVPCSITSSLEHFPQ-EEASIKEEPTRPPQNPPTNLTVVTVE-GCPTFVILDWEKPDN DTVT-E------------------------------------YEVVS-TENGASDGEKEK SIITTNQTHSTVENLKPDTSYEFHVKPKNPLGEGPSSNVVSFSTESADPRVSEPIS---- M------GKDAIWTEIPFN-S--DTYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------QFYNIGDQRGHGEDHC QFVDSFLDGRTGQQ---EDLPVKDGFFRAVRQEPVKFGKIGGETRINYVRWYECGTSIPG KW >ENSMUNP00000006225 ---------------------M-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------Q-----------------------SMCH--------QLY------------- ---------------------------------------SV------------------- --------------------------------------------------------K-RQ SLKVQINATDDTICMRYLRASQNTRLEGFVLGYGSSFFSNQYIPLPSEGKNYVTEL--DA EPRYLVSVRPARVSSNKKSCSGRTKNQKPLQLIVGTLTPTSVFLSWGILVNPQHD-WTAT TNCASD-RFYTVRYR--EKGKDKK-WVFQLCPVTETVVDNLKPNTLYEFGVKDNLED--- SIWSKTLNH-----------------------------------------K--------- ------------------TVLS----------SK-------------------------- ----------------------KVNGQLQNVY---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KLVPNS--------------------------------------- ------------------------------------------------------------ -------------------------------------------QTQLKLRDNK------- -----------R---------------LVPVTIIKQ------------------------ -----------------------------------------VIQN---QTQSKTSDSSSL PGAILVHLIVPGLNETQ-QKLS-----------PLLPIDDILQASTKKMAKNETRVWPAE SKTPAVQEISPE---------------------------------SL----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ---QAEKKHGPEEFKSTPKPKLVQTQNILASNEIQPLPSGSRISDVPKSPLTELA----- ------------------------------------------------------------ ------------------------------------------------------------ ------FEETQPISSGSRASCTTEVQPTRSASRDFLHVTSTPQIL--------------- ---------------------------------------TASEIQGT----GERKPFSSR STTSSMPEMSPIS----------------------------------------------- ----------------------------------------------AVTQRPKLKPTFPY LASQRTLEVTIQAPFKPITPDNVEVESASDETQLISSRTTTFAIPEMRSTKS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ VPKETQHFPS-------------------------------------------------- --------------------KPRTSPS--------------------------------- ------------------------------------------------------------ ---------------SEVPQTK-A------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------NNTRHGTS---------------------- --------EPKTSPS------PHVP----------------------------------- --------------PTRA---------------------------------S-------- ---PKES----------------------------------------------------- ------------------------------------------------------------ ----------------------RRVSSKPRAS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PGLGITYT KT-----------------APQEPQHTPFKP------------------------KADPI PDAP-------------HRKPEIV-----------PAFQEPDTTTIPHVPERT------- --KATLAP----------------TEKQFIHTKPKTSEKPRVPHTKPAIRQTTPQPIITK PSTTTEHSRATMAPKETLLIPSKPRTSVGPEV-----PQSKAA----------------- -----PRATHPGSINLVTVHVVDGYKIT-----------------------LAP------ ------------------------------------------------------------ -SETYQ------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ISPKA- ------------KTALATEIPRFST----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------APY------------------- ---------------------------------KTRFTSA-------------------- ------------------RPKLSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KSQ TRQVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------SRTT-------------------------------------- ------------------------------------------------------------ -LAP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------ARTKASGLPKWIVPTT--DEAHTPE------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------DIARQIGI-------------- ------------------------------------------------------DVQKPL EYIDNWEKAVSVTTSP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GP-----QHPPL--------PP-----PV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TQMRR KPLPPN------------------------------------------------------ ----------------TVTGKPG------------------------------------- ------------MP---------------------------------------------- -------------------A---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPAGPTTPV----------- --------R---TGTSY-KMPTA------------------------------------- ------------------------------------------------------------ -FA--------------------------------------------------------- ------------------------------------------------------------ ------------------T-PDY---YIDVTVFSSSPTSETDSSGKPRYQAPHVKY-MKK DDDVPCSITSSLEHFPQ-EEANSKEEPTRPPQNPPTNLTVVTVE-GCPTFVILDWEKPDN DTVT-E------------------------------------YEVVS-TENGATDGEKEK SIITTNQTHSTVENLKPDTSYEFHVKPRNPLGEGPSSNVVAFSTESADPRVSEPIS---- M------GKDAIWTEIPFH-S--DTYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQ---EDLPVKDGFFRAVRQEPVKFGKIGGETHINYVRWYECGTSIPG KW >ENSDNVP00000010312 ---------------------MISR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LVFLLFCGHIALTL----------------------------------- ----------------------------------------ENAEKL----------P--- --------R--------------------------------------------------- ----------------------------------------V------------------- --------------------------------------------------------K-RQ SLKVQINATDDTVCMKYLRPSQNTKLEGFVLGYGSSFFSNQYIPLPSEGKTYITEL--DA EPRYLVSVRPARNSNNKKSCSGRTKTQKPLQLVVGTLTPTSVFLSWGILVNPQHD-WTAT SNCASD-RFYTVRYR--EKDKEKK-WVFQLCPVTETVVDNLKPNTLYEFGVKDNIED--- SIWSKTFNH-----------------------------------------K--------- ------------------TVLS----------NK-------------------------- ----------------------KVNGQLQNMY---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KLVPNT--------------------------------------- ------------------------------------------------------------ -------------------------------------------QTQLTLRDNK------- -----------K---------------LVPVTIIKQ------------------------ -----------------------------------------VIQN---RTLSKTPDSSSL PGAILVHLVVPGLNETQ-QKLP-----------PLLTIDDISQASKKKIAKNETRAWPAE SKTPEVQEISPQ---------------------------------SL----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ---ETEKNNGPEEFKSTPKPELAQTQSILASNEIQPLPPGSRISDAPKSPLTELA----- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------SHGFLHVTSTPQTFATPEISDTAKDTAEL EISVPVITTEPHF-------------------LEMAMDET--------------KPLSSR SKTSGLPEMLPIS----------------------------------------------- ----------------------------------------------AAS----------- ------------------------------------------------------------ ------------------------------------------------RRPRLKSTSLPS LATQQTVKAAPDFLQVTSTFQTSASAEMSETETAADEIKPVSSRSTTSGIPETASTKSAP AETQFIPTQTKTSPQPEQSHSKSVS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------EPITFRIEPPRSTIA--------------------------------------- ----------------PKET-------QH------------------------------- ------------------------------------------------------------ -----------------------------------------------TP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------S----------------------------------------- --KPKPSPK-------------------------------------------L------- -------------HIPQAKDV-----------------------LESVTFRTDQPK-TAI VPKETHRVPS-------------------------------------------------- --------------------KPKTSPS--------------------------------- ------------------------------------------------------------ ---------------SEVPQTK-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------RETRRGPS---------------------- --------KPKTSPS------PHVP----------------------------------- --------------PTRA---------------------------------S-------- ---PKES----------------------------------------------------- ------------------------------------------------------------ ----------------------QRVSSKPKAS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPDVSQT KPVLAPITFTVEKPKA-TIAPKEPQHTPFKP------------------------KAAPI PDAP-------------YSKPEII-----------LPFHEPVTTMIPHIPERT------- --KATLAP----------------TEKQFIPTKPKTSAKPRVPHTKP------------- ------------APKETLHIPSKPKTSVGPEV-----PQTKLA----------------- -----PRTTHLGSINLITVHVVDGSKMT-----------------------LVP------ ------------------------------------------------------------ -NETYQ------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------LSPKT- ------------KSALATEIPQLKT----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------KIRLTSA-------------------- ------------------RPKPSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KLQ TRPAV------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------SRTT-------------------------------------- ------------------------------------------------------------ -LAP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------ARTKTLGLPKGIVPATGRDDVYTPE------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------DIVKLIGV-------------- ------------------------------------------------------DVEKPM EYSDTWEKMFSVTTSP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GP-----HRPPV---------P-----PV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TQMRR RPLPPN------------------------------------------------------ ----------------TVTGKPG------------------------------------- ------------SP---------------------------------------------- -------------------A---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPAGPTTLV----------- --------K---TGVPY-KTPTA------------------------------------- ------------------------------------------------------------ -SA--------------------------------------------------------- ------------------------------------------------------------ ------------------T-PDY---YVDATVFSSSPTSETDSSGKPRYQAPHVKY-MKK DDDVPCSITSSLEHFPQ-EEGGSKEEATHPPQNPPTNLTVVTVE-GCPTFVILDWEKPDN DTVT-E------------------------------------YEVVS-TENGGIDGEKEQ SIITTNQTHSTVENLKPDTSYEFHVKPRNPLGEGPSSNVVAFSTESADPRVSEPIS---- M------GKDAIWTEIPFN-S--DTFSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQ---EDLPVKDGFFRAVRQEPVKFGKIGGETQINYVRWYECGTSIPG KW >ENSFALP00000006236 ----------------------MSR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------FVCLLFCGYIALNL----------------------------------- ----------------------------------------GNTQKL----------P--- --------R--------------------------------------------------- ----------------------------------------V------------------- --------------------------------------------------------K-RQ SLKVQINATDDTVCMRYLRPSQSTKLEGFVLGYGSNLFSNQYIPLPAEGKNYLTELVADA EPRYLVSVRPARVSNNKKSCSGRNKTQKPLQLVVGTLSPTSVFLSWGILVNPQHD-WTAT SNCASD-RFYTVRYR--EKGKDKK-WVFQLCPATETVIDNLKPNTPYEFGVKDNAED--- SIWSKTLNH-----------------------------------------K--------- ------------------TILS----------SK-------------------------- ----------------------KVNGQLQNMY---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KLVPNS--------------------------------------- ------------------------------------------------------------ -------------------------------------------QTQIILSDNK------- -----------K---------------LVPVTIIKQ------------------------ -----------------------------------------IIQN---RTQAKAPDSSSL PGAILVHLIVPGLNESQ-QKLP-----------PLLTIDDIPQASRKKLAKNETGVWPAE SKTPEVQEISPQ---------------------------------SL----P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GSENSVFRNSVEYLCQIYKLKHTILVLKKPPEQKKPSQT NRSIFFPSVKMILFVLSPNRFPEFTEEKQTVSSGSKPSGTIWEVLEEIWSIRGKECTKRC RVV------------QVPVLLSYQVTSTPQT----------------------------- ---------------------------------------------------------ST- ------------------------------------------------------------ ------------------------------------------------------------ -------------STKIIEIHAAA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SESILE---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SFT------ -----------------------------------------------PKTSRPFQ----- -------------------------------------------------------WPRV- ----------------------------------T-------------------L----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------APK PPLLE---PKTSQTVEQPKSTL-ATKE--------------------------------- ------------------------------------------------------------ --AKLTTSAS-------------------------------------------------- --KPRPSA---------------------------RPQK--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------PG-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---P--QTA---------------TIPVSVTT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------R-------------------------------- --------------SPY---------------------------TYER---P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KTA------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------EV--------------- -----Y------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KPKTPPK-------------------------------------------P------- -------------HIPQAKDV-----------------------LESMTLRPDQLK-PTI VPREPQHVPF-------------------------------------------------- --------------------KPRTSLS--------------------------------- ------------------------------------------------------------ ---------------PEVPRTK-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------S------------------------------------------------- ------------------------------KDTYHRPS---------------------- --------KPKTSPS------PRVP----------------------------------- --------------PTRA---------------------------------S-------- ---QKES----------------------------------------------------- ------------------------------------------------------------ ----------------------RRVPSKPRAS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPDVPHT KP-----------------ALKEPQRIPFKP------------------------RATPI PDAP-------------YRKSEIL-----------PTFDERDTTMIPHIPERTKEEEIKT SFK--------------------------------------------AIHPTTPQPIITK SSTTTGLSRATM------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------APY------------------- ---------------------------------KTRLTSA-------------------- ------------------RPKPSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KSQ TRPAF------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------SRTT-------------------------------------- ------------------------------------------------------------ -LAP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------ARTKAPGLPK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NSGYQIKKSSVSLPTSPLRTCYSILKHCFIKL---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TTPP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GP-----QHPPI---------P-----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TQMRR KPLPPN------------------------------------------------------ ----------------TVTGKPG------------------------------------- ------------SPGI-------------------------------------------- -----SALSDVPAPPLLVTA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPAGPTSPV----------- --------R---TGTLH-KTPTA------------------------------------- ------------------------------------------------------------ -FA--------------------------------------------------------- ------------------------------------------------------------ ------------------T-PEY---YVDATVFSSSPTSETDSSGKPRYQAPHVKY-MKK DDDVPCSITSSLEHFPQ-EEVGSKEEPTRPPQNPPTNLTVVTVE-GCPSFVILDWEKPDN DTVT-E------------------------------------YEVVS-TENGGTDGEKEK SIITTNQTHSTVENLKPDTSYEFHVKPRNPLGEGPSSNVVAFSTESADPRVSEPIS---- M------GKDAIWTEIPFN-S--DTYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQ---EDLPVKDGFFRAVRQEPVKFGKIGGETQINYVRWYECGTSIPG KW >ENSMGAP00000015203 ----------------------MPR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LVLLLFCGYIAVNL----------------------------------- ----------------------------------------GSAQKL----------P--- --------R--------------------------------------------------- ----------------------------------------V------------------- --------------------------------------------------------K-RQ SLKVQINATDDTVCMRYIRPSQNTKLQGFVLGYGSSFFSNQYIPLPSDGSTYINEL--DA EPRYLVSVRPARVSNNKKSCSGRNKNQKPLQLVVGTLTPTSVFLSWGILVNPQHD-WTAT SNCASDSRFYTVRYR--EKDKEKK-WVFQLCPVTETVVDNLKPNTLYEFGVKDNMED--- SVWSKTFNH-----------------------------------------K--------- ------------------TVLS----------NK-------------------------- ----------------------KVNGQLQNMY---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KLVPST--------------------------------------- ------------------------------------------------------------ -------------------------------------------QSQFTLRDNK------- -----------K---------------LVPVTIIKQ------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------EFIGITYFKTSDQVFKNSSPEKQKISHPRNIPKATTEPSQEIIKPT SRKTVTKLTQYLLNSQHTSSLEITYTSKSALESWLPTFTSSCFCLCNHLKKTFVTGLKTD HILFSAFDETQPISSRSKTSGTTEV----------------------------------- ------------FRLRAKYYKASSSQVMILNQI--------------------------R SKTSGMPEMLPISESTATNNFHITVEKQNRPQFANSILDTFVKFWDPTWGTKGSTTDECT GLNKEPHKQDDKPHSGTEDTSKSLSIKPDDMPSSLKCISRSFPRLIVATQR--------- ------------------------------------------------------------ --------------------------RGPDFTSTAS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PKATRTMKDLSYPETKAEIHHSFLPDDPTNCDCPISLF---------------------- -PFILGTT---------FPVELHPNATLLLRNQFLLRASRSAVLLSFGVSFSKGAAVRFF TIDFPGGQLSAVHAEMLS--------------------------------PP-------- ----------------------------------------------------GKEC---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------SAFLPLLSNLH------------- --------------------------------E--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------KVHHPF------ ------------------------------------------------------------ ------------------------------------------------------LTPK-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-IPLTP--------------------------- ------------------------------------------------------------ ----------------------------KLKPSSI------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVQHVVTGNCEHHYSPK PPLPE---PKTSQTVEQQKATL------EKKMLGNNHPEVCFSELKTKTYLLTFAMMNKQ ILVIIKPVTILLNDDLRHKKNLHQIVLTNLLPTFSLP----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------A--------------------------------------- ----------------PKEI-------PR------------------------------- ------------------------------------------------------------ -----------------------------------------------IP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------S----------------------------------------- --KPKPSPK-------------------------------------------P------- -------------HIPQAED---------------------------------------- VPKESHRIPS-------------------------------------------------- --------------------RPRISPS--------------------------------- ------------------------------------------------------------ ---------------SEVPQTK-P------------------------------------ ------------------------------------------------------------ GNSQTVFIMLLTQFDIKFEERAKKKKTNKQNEQNCDSRTEKPKSTSAF------------ --------------------------KKAESHELSEQSCLLSVFFLSSPSPPDFIKEVSS LQHDFL-------------PKQTPPPLL--------------------------HCFRTS IIGSNLCCIFP------------------------------------------------- ------------------------------RETRYGPS---------------------- --------KPKTSPS------PRVP----------------------------------- --------------PTRA---------------------------------SKLLSILHF SICPKES----------------------------------------------------- ------------------------------------------------------------ ----------------------RRVTSKPRTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPDLPHT KP-----------------APKETQRTSFKP------------------------KPAPI PDAA-------------QRKPD-------------------------------------- ------TPEDTSHRIYPNFLISAATEKQFIHTKPKTSEKPRVPHTRP------------- ------------APKETLL-PFKPKSSVETEV-----PQSKPVSK----LMNSFIIPPF- ----FPQSSY-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------AGH------------------- ---------------------------------KTRLTSL-------------------- ------------------RPRPSD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KSQ ARP--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------EERLKNRG RLSEDTGAELSWTCNR-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -YLGTW------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HPPI---------P-----PV------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TPMRR KPLPPN------------------------------------------------------ ----------------TVTGKPG------------------------------------- ------------IP---------------------------------------------- -----------EAPPSVTVA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KPAGPTMPV----------- --------K---TGVPY-KTPTA------------------------------------- ------------------------------------------------------------ -FA--------------------------------------------------------- ------------------------------------------------------------ ------------------T-PEY---YVDATVFSSSPTSETDSSGKPRYLAPHVKY-MKK DDDVPCSITSSLEHFPQ-EEAGIKEEPTRPPQNPPTNLTVVTVE-GCPTFVILDWEKPDN DTVT-E------------------------------------YEVVS-TENGATDGEKEK SIITTNQTHSTVENLKPDTSYEFHVKPRNPLGEGPSSNVVAFNTESADPRVSEPIS---- M------GKDAIWTEIPFN-S--DTYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYNIGDQRGHGEDHC QFVDSFLDGRTGQQ---DDLPVKDGFFRAVRQEPVKFGKIGGETHINYVRWYECGTSIPG KW >ENSPSIP00000004221 ---------------------MISR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LVFLLFCGHIALNL----------------------------------- ----------------------------------------GNAQKL----------P--- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------R-GQ NLKVQINTTDDTICMKYLRLIPNTKLHGFILGYGSSFFSNQYIPLPSEGKSYVTEV--DA EPRYLITVRAAPVRNHRKTCSGKTKTQKPLQLVVGTLTPNSVFLSWGILVNPQHD-WTAT SSCASD-RFYTVRYR--EKDKNKK-WGFQLCPTTETVVDNLKPNTLYEFGVKDNTED--- GIWSKIFNH-----------------------------------------K--------- ------------------TILS----------NKN------------------------- ----------------------KGNGHLQNTY---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KFIPNS--------------------------------------- ------------------------------------------------------------ -------------------------------------------QTQFIPGDGT------- -----------K---------------RVPITRIKQ------------------------ -----------------------------------------VIQNITHRILPKATDRPSL AGAILVHLIVPGLNETP----PKFPKTLGMFETP-----------KKKLIMNETQMWPAE SKTPKVQEISPQ---------------------------------SF----PA------- --------TI-------------------------------------------------- -----ESFQE---------SIKPTVPAASEKSDTSS-DYNESELESTKPNIAPTPELSLN TLAHSETESGLEETNSTPKPELAQTQNILATT-------------------------KPA LKS-SFPFMETPE----------------------------------------------- ------------------------------------------------------------ --TVMVSDETQIVSS--------------------------------------------- -----------------------------------------------------------R PKPSDIPEKLP------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------TKSVTIQTTMK TVTPEASKAEAVSYDFPP------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VATTPQT----------------------------- ---------------------------------------------------------A-- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------EISEIFDLDS------------------------- ------------------------------------------------------------ --------------VTNSADLETSEPLISRIPHLLG-TMALDDIQP-VVSSPTTSDEPDI TDTKPAATSEPTVE---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SFS------ -----------------------------------------------PKTSSALE----- -------------------------------------------------------WPRE- ----------------------------------T-------------------LAPN-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-IPLIP--------------------------- ------------------------------------------------------------ ---------------------------SKLKPYPL------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVQHV-------KPAQK PLLLGQSTPKASKTIEWSKTTL-APWE--------------------------------- ------------------------------------------------------------ --TKFVTST--------------------------------------------------- ---PKPSA---------------------------RPKM--------------------- -------------------------------------------------P---------- ------------------------------QSK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------PA-------------------------------------------------- --------------EK-SIHLESNTPKFSIPLELPRTTLAPS----------KT------ ------------------------------------------------------------ --------------------KLIPSKPKVSLHPEEPKSK--------------------- ---P---AA---------------T----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------R-------------------------------- --------------KPIAV-----------PVTSKISSVTATTETLEH---P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KSTMV---------------------------------------- ---------------------SYEPQHIPSKPKASASAIPE------------------- ------------------------------------------------------------ -------------------------------------MPH------------------SK PAKS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----PIT------------PEATHKISSNDLEWPRATLAPTETQFIPSKPNTS------ -----------PEPE--------------LLHSK---------PV--------------- -----LEPITLRIEPPKSTIA--------------------------------------- ----------------PKET-------RR------------------------------- ------------------------------------------------------------ -----------------------------------------------VP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------L----------------------------------------- --KPKPSPK-------------------------------------------P------- -------------HVPQTKPA-----------------------LESTTFRTEQPK-TPL APKEVRRVPS-------------------------------------------------- --------------------KPKISPS--------------------------------- ------------------------------------------------------------ ---------------PDVPQAK-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KETQRVPS---------------------- --------KPKTSPI------PDTP----------------------------------- --------------PTKA---------------------------------A-------- ---TKEI----------------------------------------------------- ------------------------------------------------------------ ----------------------RRITSRPKTL---------------------------- ------------------------------------------------------------ ----------------------------------------------------ASPEVPPT KP-----------------VPKEIQRIPSKL------------------------KTSAS PDVP-------------HTKPGII-----------PSIQEPVTATAPYSLERA------- --KATL------------------------------------------------------ ------------APKEIRLIPSKPKASVRPEA-----PQTKP------------------ ----------------------------------------------------VP------ ------------------------------------------------------------ -NETYP------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ISFKP- ------------QTALTTENPQLKTVSYVVRTETIKPKISKPFGKTEATL---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------KVHLTPA-------------------- ------------------RPKISD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPQ TRPVL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -PGP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------GRTKTAGVVRW-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GGTPT--- ---EVVRDSTKFLMGSNVSLESNV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TRKKIDSVAIPP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------DS-----RHPPV---------A-----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TQVRR KPLPPN------------------------------------------------------ ----------------TVTGKPG------------------------------------- ------------SPGI-------------------------------------------- -----SSTSRASASSTTSAV---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RPTGPTKSL----------- --------K---TEKPR-KKPTV------------------------------------- ------------------------------------------------------------ -SA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-PEE---PVNTTVFSSSPTSETDVQGQPRFKAPYVVY-MPK GDNEPCSITSTLEHFPE-EEASNKEDATNPPQNPPSNLTVVTVE-GCPSFVVLNWTKPEN DTVT-E------------------------------------YKVVS-TENGAPTG-KEM SILTTNQTHSTVENLKPNTSYEFQVKAINPSGEGPPSDKVQFDTESADPRVSEPIS---- M------GKDAIWTEIPFN-S--NAYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------KFYSIGDQRGHGEDHC QFVDSFLDGRTGQQVSSDQLPMEDGFFRAVRQEPVKFGKIGGSTHINYVHWYECGTSIPG KW >ENSCPBP00000005092 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------MNIKFTLK--- ILRSIAFPKSTFYLFTVDMTFKEISPNISRFLDERCFKVQV------------------- --------------------------------------------------------K-GQ NLKVQINATDDTICMKYLRLSPDTKLQGFILGYGSSFFSNQYIPLPSEGKSYVTEV--DA EPRYLITVRPAPIPNHKKTCSGKTKTQKPLQLVIGTLTPTSVYLSWGILVNPQHD-WTAK SSCASD-RFYTVRYR--EKDKNKN-WGFQLCPTTETVVENLKPNTPYEFGVKDNTED--- GIWSKIFNH-----------------------------------------K--------- ------------------TILF---------TDKN------------------------- ----------------------KENGQLQNTY---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KVIPNI--------------------------------------- ------------------------------------------------------------ -------------------------------------------QTQLILRDAA------- -----------K---------------LVPITRIKE------------------------ -----------------------------------------VIQNVTRRMLPKTTNRHSL PGAILVHLIIPGLNETPQQKLPK-PETLGISETP-----------KKILVTNETRIWPAE SKTPEVQEISPW---------------------------------VF----PA------- --------TT-------------------------------------------------- -----ESVQE---------SIKPTVSAASEKSEASP-AHSKNELESAEPSIAPMTELPLN TLAHSETDSGLEETKSIPKPDLAQTQNI-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----PAFDETQFVSS--------------------------------------------- -----------------------------------------------------------R SKPSGVPEKLP------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------TESVTIQTTPK PVTREASKAEAA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------FDDTHP-VFSNPTTSDEPDR TDLKPAATSEPTLE---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SFS------ -----------------------------------------------PKTSSPLE----- -------------------------------------------------------WPRE- ----------------------------------T-------------------LAPN-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-APLIP--------------------------- ------------------------------------------------------------ ---------------------------SKLKPSPL------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVQHV-------KPAQK PPLLEHSTPKASKTIERPKTTL-APWE--------------------------------- ------------------------------------------------------------ --TKFVPST--------------------------------------------------- ---PKPSA---------------------------RPKM--------------------- -------------------------------------------------P---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------PA-------------------------------------------------- --------------EK-AIHLESNTPKFSNPLELPRTTLAPS----------KT------ ------------------------------------------------------------ --------------------KRIPSKPKVSLHPEEPKTK--------------------- -------LA---------------T----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------R-------------------------------- --------------KPVPV-----------PVTNKISSITATTKTLEH---P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KSTMV---------------------------------------- ---------------------SYEPQHIPSKPKASASAMPE------------------- ------------------------------------------------------------ -------------------------------------MPH------------------SK PESSEIHFT----------------------------------------------PLKPK SS---------------------------------------------------------- -------TEPKM------------------------------------------------ -PQSKP---------------------------------APTETQFIPSKPNTS------ -----------PEPE--------------LPHPK---------PV--------------- -----LEHITLRIEPPRSTIA--------------------------------------- ----------------PKET-------RR------------------------------- ------------------------------------------------------------ -----------------------------------------------VP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------L----------------------------------------- --KPKTSPK-------------------------------------------P------- -------------HVPQTKPV-----------------------PEAATFRTQQPK-TPL APKEARRVPS-------------------------------------------------- --------------------KPKTSPS--------------------------------- ------------------------------------------------------------ ---------------PDVPQAK-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KEVRRVPS---------------------- --------KPKTSPI------PDVP----------------------------------- --------------PTKP---------------------------------A-------- ---AKDN----------------------------------------------------- ------------------------------------------------------------ ----------------------RRVPSKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPDVPQT KS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------APH------------------- ---------------------------------KVRLTSA-------------------- ------------------RPKIFD------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPQ TRPAL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKTT-------------------------------------- ------------------------------------------------------------ -PGP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------GRTKTAGAMKW-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GGTPTGDK ---ETVQNFTNFLMGTNISLESNI------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TWKNPDSVATAP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------DR-----RHPPL---------A-----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TQVRR KPLPPN------------------------------------------------------ ----------------TVTGKPG------------------------------------- ------------SAGIALKSRAPPSP---------------------------------M TIVAKS------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------TGPTISL----------- --------K---METPR-KKPTV------------------------------------- ------------------------------------------------------------ -SA--------------------------------------------------------- ------------------------------------------------------------ ------------------SPPED---YVNTTVFSSSPTSETDSLGKQRFTGPHVKY-IPK NDSEPCSITRTLKYFQE-KTISNTENVTSPPRNPPSNLTVVTVE-GCPSFVVLNWTKPEN DTVT-Y------------------------------------YVVLS-TVNGTSNG-TQT ITITTKQTHCIVENLEPNKSYEFQVKGGNTNGTGPSTPLVSFSTESADPKVSEPIS---- M------GKDAIWTEVPFN-S--NSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------QFYDIGDERGHGEDHC QFVDSFLDGRTGQKVFPDQLPPKDGFFRAVRQEPVKFGKIGGGTHIAYVHWYECGTSIPG KW >ENSGAGP00000017676 ---------------------MISR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------LVFLLFCGHIALNL----------------------------------- ----------------------------------------GNAQKL----------P--- --------R-------------------------------------VKR----------- ------------------------------------------------------------ -----------------------------------------------------------Q NLKVQINATDDTICMKYLRLSPDTKLQGFILGYGSSGFSNQYIPLPSEGKSYVTEV--DA EPRYLITVRPAPIPNHKKTCSGKTKTQKPLRLVVGTLTPTSVYLSWGILVNPQHD-WTAM SSCASD-RFYTVRYR--EKDKNKN-WGFQLCPTTETVVENLKPNTPYEFGVKDNTED--- GIWSKIFNH-----------------------------------------K--------- ------------------TILF----------NKN------------------------- ----------------------KENGQLQNTY---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KVIPNI--------------------------------------- ------------------------------------------------------------ -------------------------------------------QTQLILKDGP------- -----------K---------------LVPVTIIKQ------------------------ -----------------------------------------VIQNVTRRMLPKTTDRPSM AGAILVHLIIPGLNETPQQKLPK-PETLGISETP-----------KKILVINETQTWPAE SKTSEVQEISPR---------------------------------IF----PA------- --------TI-------------------------------------------------- -----ESVQE---------SIKPTMSASSEKSEASP-AHSKNEQESAEPSIAPTTELPLN TLAHSETESGLEETKSIPKPDPAQTQNILASNEMQLIPSGSKISDTPKILQTKPAIKKPA LKSTSFPSMETPG----------------------------------------------- ------------------------------------------------------------ --TVMAFDETQFVSS--------------------------------------------- -----------------------------------------------------------R SKPSGIPEKLP------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------TKSVTIQTTPK PVTPEASKAEVASYDFLH------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VSSTPQT----------------------------- ---------------------------------------------------------S-- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------EISEILVPES------------------------- ------------------------------------------------------------ --------------VTNSADLETSVPLISRIPHLLGTTMVFDDTHP-VFSNPTTSDEPDR TALKPAATSEPTLE---------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------SFS------ -----------------------------------------------PKTSSPLE----- -------------------------------------------------------WPRE- ----------------------------------T-------------------LAPN-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------E-ATLIP--------------------------- ------------------------------------------------------------ ---------------------------SKLKPSPL------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P---------------EVQHV-------KPAQK PPLLEHSTPKASKTIERPKATL-APWE--------------------------------- ------------------------------------------------------------ --TKFVPST--------------------------------------------------- ---PKPSA---------------------------RPKM--------------------- -------------------------------------------------Q---------- ------------------------------RTK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------L-------------------------------------------------- --------------EK-AILLESNTPKFSNPLELPRTTLAPS----------KT------ ------------------------------------------------------------ --------------------KRIPSKPKVSLRPEEPKTK--------------------- ---P---AA---------------T----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------R-------------------------------- --------------EPVPV-----------PVTIKISSITATTKTLEH---P-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KSTMV---------------------------------------- ---------------------SYEPQHIPSKPKASASAMPE------------------- ------------------------------------------------------------ -------------------------------------MPH------------------SK PESSEIHFT----------------------------------------------PLKPK SS---------------------------------------------------------- -------SEPKM------------------------------------------------ -PQSKP---------------------------------AP--TQFIPSNPSRF------ -----------PEPE--------------LPHPK---------PV--------------- -----LEHITLRIEPPRSTIA--------------------------------------- ----------------PKET-------RR------------------------------- ------------------------------------------------------------ -----------------------------------------------VP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------L----------------------------------------- --KPKTSPK-------------------------------------------P------- -------------HVSQTKPA-----------------------PDAAIFRTEQPK-TPL APKEARRVPS-------------------------------------------------- --------------------KPKSSPS--------------------------------- ------------------------------------------------------------ ---------------PDVPQTK-P------------------------------------ ------------------------------------------------------------ ----------------------------------------------A------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------KETWRVPS---------------------- --------KPKISTI------PDVP----------------------------------- --------------PTKP---------------------------------A-------- ---AKDN----------------------------------------------------- ------------------------------------------------------------ ----------------------RRVPSKPKTS---------------------------- ------------------------------------------------------------ ----------------------------------------------------PSPDVPQT KS-----------------VPKETQRVPSKV------------------------KTSPS PDVP-------------HTKPGAI-----------RSLQEPVTVTTPHSLERA------- --KATLAS----------------SEKPFIPTKPKTSIKPGMPQTKPAIYRTSPQPLITK PSVTSKQTKATMAPKETRLIPSKPKTSVRPEV-----LQTKP------------------ ----------------------------------------------------VP------ ------------------------------------------------------------ -NETYQ------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ISFKP- ------------QTVLTTENPLFKTASYVIHTETIKPKISKPFGKTEATL---------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------APN------------------- ---------------------------------KVRLTSA-------------------- ------------------RPKIFV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KPQ TRPAL------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKIT-------------------------------------- ------------------------------------------------------------ -PGP-------------------------------------------------------- ------------------------------------------------------------ -----------------------------GRTKTAGVMRW-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GGTPT--- ---ETVQNFTNFLMGSNISLESNI------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TRKKPESVATAP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GR-----RHPPL---------A-----PA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------KP--------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------TQVRR KPLPPN------------------------------------------------------ ----------------TVTGKPG------------------------------------- ------------SAGIALKSRAPPSP---------------------------------T TIVAKS------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------TGPTISL----------- --------K---METPR-KKPTV------------------------------------- ------------------------------------------------------------ -SA--------------------------------------------------------- ------------------------------------------------------------ ------------------S-PED---YVNTTVFSSNPTSETDSLGKQRFTGPHVKY-IPK NDSEPCSITRTLKYFQE-QKVREQENVTSPPQNPPSNLTVVTVE-GCPSFVILNWTKPEN DTVT-Y------------------------------------YVVLS-TVNGTSNG-TEK ITITTKQTHCIVENLEPNRSYDFQVKARNPLGEGPSTPKVPFSTESADPRVSESIS---- M------GKDAIWTEVPFN-S--DSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSD SLTG----------------------------------------QFYNIGDERGHGEDHC QFVDSFLDGRTGQQVFPDQLPTKDGFFRAVRQEPVKFGKIGGETHITYVHWYECGTSIPG KW