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-------------------------xxx---------------------- --------xxG--------------------------------------- ------------------------------------K-RPNLKVHINTTS DSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLI NPHHD-WTLPSHCPND-RFYTIRYR--EKxKEKK-WIFQICPATETIVEN LKPNTVYEFGVKDNVEG---GIWSKIFNH--------------------- --------------------K---------------------------TV VG----------xx------------------------------------ ------------KVxxxxQSTYxxxxxV---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------R------------------K-------- -------xxxxTIIKx---------------------------------- -------------------------------xIQNxxxxxxTKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLxF-----------EISDALKTQLA KNETLALPAKSKTPEVEKISAR---------------------------- -----------ST---------------TE-------------------- ---------------------------------TxETVPR---------T TKPTTSSALDVSETTLxxVSxRTPETLQTVLIPQFELPLxTL-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------A-----------------PKxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xFPEA----------- -------------------------------------------------- -------------------------------------------------- -----------------KTP------------------------------ -------------------------------------------------- ---------------------------FPFE------------------- -------------------------------------------------- -------------------------------------------------- ---------------KPGGxWAS-SEKPW------------TVPTAKTSE DSKVLQ------------PQx----------------------------- -------------------------------------------------- -------ATYD--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------VFS SPTTSDEPEISESY-TATSDRILD-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------SVP---------------- -------------------------------------PKTSRTLE----- -------------------------------------------------- -----QPRA-----------------------------------T----- --------------LAPR-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------E-TP FVP----------------------------------------------- -------------------------------------------------- -----------------QKLEIFTS------------------------- 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---------------TPPxRKPLPPx------------------------ ----------------------------------------------NVTG KPG----------------------------------------------- --xxxx-------------------------------------------- -----xxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xPTGxxx-E-------------------R- --IATDI-KQPTV------------------------------------- -------------------------------------------------- -----------PA------------------------------------- -------------------------------------------------- ------------------------------------------------S- GEE---MENITDFSSSPTRETDPLGKPRFKGPHVRY-LQKPDDSPCSITD SVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTxT-E------------------------------------YEVIS-RE NGSxSG-KNKSIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTV AFSTESADPRVSEPVS----A------GRDAIWTERPFD-S--DSYSECK GKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTG---------------- ------------------------KFYNIGDQRGHGEDHCQFVDSFLDGR TGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSMMUP00000069505 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xx----------------------------- -------------------------xxx---------------------- --------xxG--------------------------------------- ------------------------------------K-RPNLKVHINTTS DSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLI NPHHD-WTLPSHCPND-RFYTIRYR--EKxKEKK-WIFQICPATETIVEN LKPNTVYEFGVKDNVEG---GIWSKIFNH--------------------- --------------------K---------------------------TV VG----------xx------------------------------------ ------------KVxxxxQSTYxxxxxV---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------R------------------K-------- -------xxxxTIIKx---------------------------------- -------------------------------xIQNxxxxxxTKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLxF-----------EISDALKTQLA KNETLALPAKSKTPEVEKISAR---------------------------- -----------ST---------------TE-------------------- ---------------------------------TxETVPR---------T TKPTTSSALDVSETTL-xVSxRTPETLQTVLIPQFELPLxTL-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------A-----------------PKxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xFPEA----------- -------------------------------------------------- -------------------------------------------------- -----------------KTP------------------------------ -------------------------------------------------- ---------------------------FPFE------------------- -------------------------------------------------- -------------------------------------------------- ---------------KPGGxWAS-SEKPW------------IVPTAKISE DSKVLQ------------PQx----------------------------- -------------------------------------------------- -------ATYD--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------VFS SPTTSDEPEISESY-TATSDRILD-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------SVP---------------- -------------------------------------PKTSRTLE----- -------------------------------------------------- -----QPRA-----------------------------------T----- --------------LAPR-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------E-TP FVP----------------------------------------------- -------------------------------------------------- -----------------QKLEIFTS------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------P---------------EMxPTTA-------------------- -------------APQQ--------------------------------- -------------------------------------------------- ------------TTSxPST------------------------------- -----------------------PKRxx---------------------- -----xxxP----------------------------------------- -----------------------------P-------------------- --------------------Rxx--------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------x--------------------- --------------------------------------------xR-TTS AGTITPKISKSPEPTWxxxAxS----------KT---------------- -------------------------------------------------- --------------------QFISLxxxxxxxxxxxxxx----------- -------------xxxxPQ---------------xxxxxxxxxx------ --------------------xxxxx-----------xxx----------- ---------------------------------xxxxxxx-xxxxK---- -----------------------------------xxGx--xx------- ---------------xxx-------------------------------- ---------------xx--------------------------------- -x------------------------------------------------ -------------------------------------------------- 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--------------------xPTGxxx-E-------------------R- --IATDI-KQPTV------------------------------------- -------------------------------------------------- -----------PA------------------------------------- -------------------------------------------------- ------------------------------------------------S- GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-LQKPDDSPCSITD SVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTxT-E------------------------------------YEVIS-RE NGSxSG-KNKSIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTV AFSTESADPRVSEPVS----A------GRDAIWTERPFD-S--DSYSECK GKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTG---------------- ------------------------KFYNIGDQRGHGEDHCQFVDSFLDGR TGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSMNEP00000033340 xxxxxx--------------xxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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-------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------R------------------K-------- -------xxxxTIIKx---------------------------------- -------------------------------VIQNxxxxxxTKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLxF-----------EISDALKTQLA KNETLALPAKSKTPEVEKISAR---------------------------- -----------ST---------------TE-------------------- ---------------------------------TxETVPR---------T TKPTTSSALDVSETTL-VVSxRTPETLQTVLIPQFELPLxTL-------- -------------------------------------------------- -------------------------------------------------- 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FVP----------------------------------------------- -------------------------------------------------- -----------------QKLEIFTS------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------P---------------EMxPTTA-------------------- -------------APQQ--------------------------------- -------------------------------------------------- ------------TTSxPST------------------------------- -----------------------PKRxx---------------------- -----xxxP----------------------------------------- -----------------------------P-------------------- --------------------Rxx--------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------P--------------------- --------------------------------------------xR-TTS 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---RP--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------TPPxRKPLPPx------------------------ ----------------------------------------------NVTG KPG----------------------------------------------- --xxxx-------------------------------------------- -----xxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xPTGxxx-E-------------------R- --IATDI-KQPTV------------------------------------- -------------------------------------------------- -----------PA------------------------------------- -------------------------------------------------- ------------------------------------------------S- GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-LQKPDDSPCSITD SVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTxT-E------------------------------------YEVIS-RE NGSxSG-KNKSIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTV AFSTESADPRVSEPVS----A------GRDAIWTERPFD-S--DSYSECK GKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTG---------------- ------------------------KFYNIGDQRGHGEDHCQFVDSFLDGR TGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSMFAP00000023241 xxxxxx--------------xxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxAL----------------------------------- ----------------------------------------xxxxxx---- ------x-----------K------------------------------- -------------------------------------------------- ----------G--------------------------------------- ------------------------------------K-RPNLKVHINTTS DSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLI NPHHD-WTLPSHCPND-RFYTIRYR--EKxKEKK-WIFQICPATETIVEN LKPNTVYEFGVKDNVEG---GIWSKIFNH--------------------- --------------------K---------------------------TV VG----------xx------------------------------------ ------------KVxxxxQSTYxxxxxV---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------R------------------K-------- -------xxxxTIIKx---------------------------------- -------------------------------VIQNxxxxxxTKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLxF-----------EISDALKTQLA KNETLALPAKSKTPEVEKISAR---------------------------- -----------ST---------------TE-------------------- ---------------------------------TxETVPR---------T TKPTTSSALDVSETTL-xVSxRTPETLQTVLIPQFELPLxTL-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------A-----------------PKxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xFPEA----------- 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-------------------------------SVP---------------- -------------------------------------PKTSRTLE----- -------------------------------------------------- -----QPRA-----------------------------------T----- --------------LAPR-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------E-TP FVP----------------------------------------------- -------------------------------------------------- -----------------QKLEIFTS------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------P---------------EMxPTTA-------------------- 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xDQxxxxxxxxxxxxxTELAKxxx-------------------------- -------------------------------------------------- --------------------------------------APH--------- -------------------------------------------RFYTT-V --------------------------------------RPRTSD------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------KPH IRPVL--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------HR xx------------------------------------------------ -------------------------------------------------- -xxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxGMPS----------------xxxxxx------------------- -----------------------------x-------------------- -------------------------------------------------- -----------xxxAxx--------------------------------- -------------------------------------------------- ---------------xSGA---------------xxxxxxDx-------- ---------------------------------------------x-xx- ---------------------------x----------------xx---- -------------------------------------------------- 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-------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxAL----------------------------------- ----------------------------------------xxxxxx---- ------x-----------K------------------------------- -------------------------------------------------- ----------G--------------------------------------- ------------------------------------K-RPNLKVHINTTS DSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLI NPHHD-WTLPSHCPND-RFYTIRYR--EKxKEKK-WIFQICPATETIVEN LKPNTVYEFGVKDNVEG---GIWSKIFNH--------------------- --------------------K---------------------------TV VG----------xx------------------------------------ ------------KVxxxxQSTYxxxxxV---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------R------------------K-------- -------xxxxTIIKx---------------------------------- -------------------------------VIQNxxxxxxTKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLxF-----------EISDALKTQLA KNETLALPAKSKTPEVEKISAR---------------------------- -----------ST---------------TE-------------------- ---------------------------------TxETVPR---------T TKPTTSSALDVSGTTL-xVSxRTPETLQTILIPQFELPLxTL-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------A-----------------PKxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xFPEA----------- -------------------------------------------------- -------------------------------------------------- -----------------KTP------------------------------ -------------------------------------------------- ---------------------------FPFE------------------- -------------------------------------------------- -------------------------------------------------- ---------------KPGGxLAS-SEKPW------------IVPTAKISE 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-------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---RP--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xPxRKPLPPx------------------------ ----------------------------------------------NVTG KPG----------------------------------------------- --xxxx-------------------------------------------- -----xxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xPTGxxx-E-------------------R- --IATDI-KQPTV------------------------------------- -------------------------------------------------- -----------PA------------------------------------- -------------------------------------------------- ------------------------------------------------S- GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-LQKPDDSPCSITD SVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTxT-E------------------------------------YEVIS-RE NGSxSG-KNKSIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTV AFSTESADPRVSEPVS----A------GRDAIWTERPFD-S--DSYSECK GKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTG---------------- ------------------------KFYNIGDQRGHGEDHCQFVDSFLDGR TGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSTGEP00000031460 xxxxxx--------------xxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxAL----------------------------------- ----------------------------------------xxxxxx---- ------x-----------K------------------------------- -------------------------------------------------- ----------G--------------------------------------- ------------------------------------K-RPNLKVHINTTS DSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLI NPHHD-WTLPSHCPND-RFYTIRYR--EKxKEKK-WIFQICPATETIVEN LKPNTVYEFGVKDNVEG---GIWSKIFNH--------------------- --------------------K---------------------------TV VG----------xx------------------------------------ ------------KVxxxxQSTYxxxxxV---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------R------------------K-------- -------xxxxTIIKx---------------------------------- -------------------------------VIQNxxxxxxTKSPEKTPL GGVILVHLIIPGLNETT-VKLPA-SLxF-----------EISDALKTQLA KNETLALPAKSKTPEVEKISAR---------------------------- -----------ST---------------TE-------------------- ---------------------------------TxETVPR---------T TKPTTSSALDVSGTTL-xVSxRTPETLQTILIPQFELPLxTL-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------A-----------------PKxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xFPEA----------- -------------------------------------------------- -------------------------------------------------- -----------------KTP------------------------------ -------------------------------------------------- ---------------------------FPFE------------------- -------------------------------------------------- -------------------------------------------------- ---------------KPGGxLAS-SEKPW------------IVPTAKISE DSKVLQ------------PQx----------------------------- -------------------------------------------------- -------ATYD--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------VFS SPTTSDEPEISESY-TATSDRILD-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------SVP---------------- -------------------------------------PKTSRTLE----- -------------------------------------------------- -----QPRA-----------------------------------T----- --------------LAPR-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------E-TP FVP----------------------------------------------- -------------------------------------------------- -----------------QKLEIFTS------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------P---------------EMxPTTA-------------------- -------------APQQ--------------------------------- -------------------------------------------------- ------------TTSxPST------------------------------- -----------------------PKRxx---------------------- -----xxxP----------------------------------------- -----------------------------P-------------------- --------------------Rxx--------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------x--------------------- --------------------------------------------xR-TTS AGTITPKISKSPEPTWxxxAxS----------KT---------------- -------------------------------------------------- --------------------QFISLxxxxxxxxxxxxxx----------- -------------xxxxPQ---------------xxxxxxxxxx------ --------------------xxxxx-----------xxx----------- ---------------------------------x-xxxxx-xxxxK---- -----------------------------------xxGx--xx------- ---------------xxx-------------------------------- ---------------xx--------------------------------- -x------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxx------------ -------------------------------------------------- -----------------xxxx----------------------------- -------------------------------------------------- -------------------------------------xxx---------- --------xxx---------xxxxx-------------------xxxxxx xxxxxxxxxS------xxxxxx---------------------------- -------------------------------------xxxxx-------- -----------------------------------------xxxxx---- ------xxxxx----------------------xQLLP-KPQAT------ -----------xEPD--------------MPxxK---------SxxxPVA FETEAPSMTIVPTTxIEPVTVRTEAxxxxxx------------------- ------------------------------------xxTxxxxxTR--x- ---------------xxxx-HKTTPRPET---PQTKLDFGPITPGTSSAP -------------TTTKRx-------------xxPxxxxxxxxxxx---- ---xxxxxx----------------------------xxxxxxx------ ---------------xx-xxxxxxxxxxxPxxP----------------- ---QRT------------------------------------RRPHPKPK xTxxxxxxxxELVPATIFEPVSPIKEAPGxTxV----------------- ----------------------P--------------------------V TDL----------------------------------------------- ------xxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxATTxx-xKTSKRTRxxxxxx--x-xxxxxx AxxxxxVPATxxxPx-------------------xxxPExx-x------- -------------------------------------------------- ------------------------------------------xxxxxTSx xxxxxxxxxxxxxxxxxxxxxxxxxA------------------------ -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxxxxxxxTQAPKxxxxxxxxxxxxxxxxx- ------------------------------------------x------- -------------xxxxxxxxxxTDLEPGTLRTExxxxxxxxxxxxxxxx xxxxxx-xxxxxxx-QRTR-------------xxxx--xxxxx-xxxxxx xxxxxSVTGF------EPVVHSTDATGTTFAPTDLQTLILKPVTSPSLEM TESQPVSDVLESVTFSTxxxxxTIxxxKxxxxxxxxxxxxxxxxxxxx-V VESVTYVSEP-------------xxx---xxxxxxxxxxSITLx------ ----xxxxxxxx-x------------------------------------ -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -------------------------------------------------- -------------------------------------------------- x------------------------------------------------- ------------------------------xxxxxxxx------------ ------------------xxxxxxx------xxxx--------------- ----------------------------------xxxx------------ ---------------------x-----------xxxx------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxTxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- ----------------------PSPEVSYTTP------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxx-xxxxx----xxx-----SQS xx------------------------------------------------ ----------------------AP-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---LETRGIPFxxxxxxxx---xxxxxxxxx------------------- ------------------------------------------------xx xDQxxxxxxxxxxxxxTELAKxxx-------------------------- -------------------------------------------------- --------------------------------------APH--------- -------------------------------------------RFYTT-V --------------------------------------RPRTSD------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------KPH IRPVL--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------HR xx------------------------------------------------ -------------------------------------------------- -xxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxGMPS----------------xxxxxx------------------- -----------------------------x-------------------- -------------------------------------------------- -----------xxxAxx--------------------------------- -------------------------------------------------- ---------------xSGA---------------xxxxxxDx-------- ---------------------------------------------x-xx- ---------------------------x----------------xx---- -------------------------------------------------- ---------------x---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----GT-----RRPPL---------P-----x------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---RP--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------TPPxRKPLPPx------------------------ ----------------------------------------------NVTG KPG----------------------------------------------- --xxxx-------------------------------------------- -----xxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xPTGxxx-E-------------------R- --IATDI-KQPTV------------------------------------- -------------------------------------------------- -----------PA------------------------------------- -------------------------------------------------- ------------------------------------------------S- GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-LQKPDDSPCSITD SVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTxT-E------------------------------------YEVIS-RE NGSxSG-KNKSIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTV AFSTESADPRVSEPVS----A------GRDAIWTERPFD-S--DSYSECK GKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTG---------------- ------------------------KFYNIGDQRGHGEDHCQFVDSFLDGR TGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSCATP00000000742 xxxxxx--------------xxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxAL----------------------------------- ----------------------------------------xxxxxx---- ------x-----------K------------------------------- -------------------------------------------------- ----------G--------------------------------------- ------------------------------------K-RPNLKVHINTTS DSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLI NPHHD-WTLPSHCPND-RFYTIRYR--EKxKEKK-WIFQICPATETIVEN LKPNTVYEFGVKDNVEG---GIWSKIFNH--------------------- --------------------K---------------------------TI VG----------xx------------------------------------ ------------KVxxxxQSTYxxxxxV---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------R------------------K-------- -------xxxxTIIKx---------------------------------- -------------------------------xIQNxxxxxxTKSPEKAPF GGVILVHLIIPGLNETT-VKLPA-SLxF-----------EISDALKTQLA KNETLALPAKSKTPEVEKISAR---------------------------- -----------ST---------------TE-------------------- ---------------------------------TxEAVPR---------T TKPTTSSALDVSGTTL-xVSxRTPETLQTILIPQFELPLxTL-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------A-----------------PKxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xFPEA----------- -------------------------------------------------- -------------------------------------------------- -----------------KTP------------------------------ -------------------------------------------------- ---------------------------FPFE------------------- -------------------------------------------------- -------------------------------------------------- ---------------KPGGxLAS-SEKPW------------IVPTAKISE DSKVLQ------------PPx----------------------------- -------------------------------------------------- -------ATYD--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------VFS SPTTSDEPEISESY-TATSDRILD-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------SVP---------------- -------------------------------------PKTSRTLE----- -------------------------------------------------- -----QPRA-----------------------------------T----- --------------LAPR-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------E-TP FVP----------------------------------------------- -------------------------------------------------- -----------------QKLEIFTS------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------P---------------EMxPTTA-------------------- -------------APQQ--------------------------------- -------------------------------------------------- ------------TTSxPST------------------------------- -----------------------PKRxx---------------------- -----xxxP----------------------------------------- -----------------------------P-------------------- --------------------Rxx--------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------x--------------------- --------------------------------------------xR-TTS AGTITPKISKSPEPTWxxxAxS----------KT---------------- -------------------------------------------------- --------------------QFISLxxxxxxxxxxxxxx----------- -------------xxxxPQ---------------xxxxxxxxxx------ --------------------xxxxx-----------xxx----------- ---------------------------------x-xxxxx-xxxxK---- -----------------------------------xxGx--xx------- ---------------xxx-------------------------------- ---------------xx--------------------------------- -x------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxx------------ -------------------------------------------------- -----------------xxxx----------------------------- -------------------------------------------------- -------------------------------------xxx---------- --------xxx---------xxxxx-------------------xxxxxx xxxxxxxxxS------xxxxxx---------------------------- -------------------------------------xxxxx-------- -----------------------------------------xxxxx---- ------xxxxx----------------------xQLLP-KPQTT------ -----------xEPD--------------MPxxK---------SxxxPVA FETEAPSMTIVPTTxIEPVTVRTEAxxxxxx------------------- ------------------------------------xxTxxxxxTR--x- ---------------xxPx-HKTTPRPET---PQTKLDFGPITPGTSSAP -------------TTTKRx-------------xxPxxxxxxxxxxx---- ---xxxxxx----------------------------xxxxxxx------ ---------------xx-xxxxxxxxxxxPxxP----------------- ---QRT------------------------------------RRPHPKPK xTxxxxxxxxELVPATIFEPVSPIKEAPGxTxV----------------- ----------------------P--------------------------V TDL----------------------------------------------- ------xxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxATTxx-xKTSKRTRxxxxxx--x-xxxxxx AxxxxxVPATxxxPx-------------------xxxPExx-x------- -------------------------------------------------- ------------------------------------------xxxxxTSx xxxxxxxxxxxxxxxxxxxxxxxxxA------------------------ -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxxxxxxxTQAPKxxxxxxxxxxxxxxxxx- ------------------------------------------x------- -------------xxxxxxxxxxTDLEPGTLRTExxxxxxxxxxxxxxxx xxxxxx-xxxxxxx-QRTR-------------xxxx--xxxxx-xxxxxx xxxxxSVTGF------EPVVHRTDAPETTFAPTDLQTLILKPVTSPSLEM TESQPVSDVLESVTFSTxxxxxTIxxxKxxxxxxxxxxxxxxxxxxxx-V VESVTYVSEP-------------xxx---xxxxxxxxxxSITLx------ ----xxxxxxxx-x------------------------------------ -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -------------------------------------------------- -------------------------------------------------- x------------------------------------------------- ------------------------------xxxxxxxx------------ ------------------xxxxxxx------xxxx--------------- ----------------------------------xxxx------------ ---------------------x-----------xxxx------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxTxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- ----------------------PSPEVSYTTP------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxx-xxxxx----xxx-----SQS xx------------------------------------------------ ----------------------AP-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---LETRGIPFxxxxxxxx---xxxxxxxxx------------------- ------------------------------------------------xx xDQxxxxxxxxxxxxxxEPAKxxx-------------------------- -------------------------------------------------- --------------------------------------APH--------- -------------------------------------------RFYTT-V --------------------------------------RPRTSD------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------KPH IRPVL--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------HR xx------------------------------------------------ -------------------------------------------------- -xxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxGMPS----------------xxxxxx------------------- -----------------------------x-------------------- -------------------------------------------------- -----------xxxAxx--------------------------------- -------------------------------------------------- ---------------xSGA---------------xxxxxxDx-------- ---------------------------------------------x-xx- ---------------------------x----------------xx---- -------------------------------------------------- ---------------x---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----GT-----RRPPL---------P-----x------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---RP--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------TPPxRKPLPPx------------------------ ----------------------------------------------NVTG KPG----------------------------------------------- --xxxx-------------------------------------------- -----xxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xPTGxxx-E-------------------R- --IATDI-KQPTV------------------------------------- -------------------------------------------------- -----------PA------------------------------------- -------------------------------------------------- ------------------------------------------------S- GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-LQKPDDSPCSITD SVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTxT-E------------------------------------YEVIS-RE NGSxSG-KNKSIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTV AFSTESADPRVSEPVS----A------GRDAIWTERPFD-S--DSYSECK GKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTG---------------- ------------------------KFYNIGDQRGHGEDHCQFVDSFLDGR TGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSMLEP00000022825 xxxxxx--------------xxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxAL----------------------------------- ----------------------------------------xxxxxx---- ------x-----------K------------------------------- -------------------------------------------------- ----------G--------------------------------------- ------------------------------------K-RPNLKVHINTTS DSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLI NPHHD-WTLPSHCPND-RFYTIRYR--EKxKEKK-WIFQICPATETIVEN LKPNTVYEFGVKDNVEG---GIWSKIFNH--------------------- --------------------K---------------------------TI VG----------xx------------------------------------ ------------KVxxxxQSTYxxxxxV---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------R------------------K-------- -------xxxxTIIKx---------------------------------- -------------------------------VIQNxxxxxxTKSPEKAPL GGVI--------------------------------------------xA KNETLALPAKSKTPEVEKISAR---------------------------- -----------ST---------------TE-------------------- ---------------------------------TxETVPR---------T TKPTTSSALDVSGTTL-xVSxRTPETLQTILIPQFELPLxTL-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------A-----------------PKxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xFPEA----------- -------------------------------------------------- -------------------------------------------------- -----------------KTP------------------------------ -------------------------------------------------- ---------------------------FPFE------------------- -------------------------------------------------- -------------------------------------------------- ---------------KPGGxWAS-SEKPW------------IVPTAKISE DSKVLQ------------PQx----------------------------- -------------------------------------------------- -------ATYD--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------VFS SPTTSDEPEISESY-TATSDRILD-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------SVP---------------- -------------------------------------PKTSRTLE----- -------------------------------------------------- -----QPRA-----------------------------------T----- --------------LAPR-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------E-TP FVP----------------------------------------------- -------------------------------------------------- -----------------QKLEIFTS------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------P---------------EMxPTTA-------------------- -------------APQQ--------------------------------- -------------------------------------------------- ------------TTSxPST------------------------------- -----------------------PKRxx---------------------- -----xxxP----------------------------------------- -----------------------------P-------------------- --------------------Rxx--------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------x--------------------- --------------------------------------------xR-TTS AGTITPKISKSPEPTWxxxAxS----------KT---------------- -------------------------------------------------- --------------------QFISLxxxxxxxxxxxxxx----------- -------------xxxxPQ---------------xxxxxxxxxx------ --------------------xxxxx-----------xxx----------- ---------------------------------x-xxxxx-xxxxK---- -----------------------------------xxGx--xx------- ---------------xxx-------------------------------- ---------------xx--------------------------------- -x------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxx------------ -------------------------------------------------- -----------------xxxx----------------------------- -------------------------------------------------- -------------------------------------xxx---------- --------xxx---------xxxxx-------------------xxxxxx xxxxxxxxxS------xxxxxx---------------------------- -------------------------------------xxxxx-------- -----------------------------------------xxxxx---- ------xxxxx----------------------xQLLP-KPQTT------ -----------xEPD--------------MPxxK---------SxxxPVA FETEAPSMTIVPTTxIEPVTVRTEAxxxxxx------------------- ------------------------------------xxTxxxxxTR--x- ---------------xxxx-HKTTPRPET---PQTKLDFGPITPGTSSAP -------------TTTKRx-------------xxPxxxxxxxxxxx---- ---xxxxxx----------------------------xxxxxxx------ ---------------xx-xxxxxxxxxxxPxxP----------------- ---QRT------------------------------------RRPHPKPK xTxxxxxxxxELVPATIFEPVSPIKEAPGxTxV----------------- ----------------------P--------------------------V TDL----------------------------------------------- ------xxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxATTxx-xKTTKRTRxxxxxx--x-xxxxxx AxxxxxVPATxxxPx-------------------xxxPExx-x------- -------------------------------------------------- ------------------------------------------xxxxxTSx xxxxxxxxxxxxxxxxxxxxxxxxxA------------------------ -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxxxxxxxTQAPKxxxxxxxxxxxxxxxxx- ------------------------------------------x------- -------------xxxxxxxxxxADLEPGTLRTExxxxxxxxxxxxxxxx xxxxxx-xxxxxxx-QRTR-------------xxxx--xxxxx-xxxxxx xxxxxSVTGF------EPVVHRTDAPETTFAPTDLQTLILKPVTSPSLEM TESQPVSDVLESVTFSTxxxxxTIxxxKxxxxxxxxxxxxxxxxxxxx-V VESVTYVSEP-------------xxx---xxxxxxxxxxSITLx------ ----xxxxxxxx-x------------------------------------ -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -------------------------------------------------- -------------------------------------------------- x------------------------------------------------- ------------------------------xxxxxxxx------------ ------------------xxxxxxx------xxxx--------------- ----------------------------------xxxx------------ ---------------------x-----------xxxx------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxTxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- ----------------------PSPEVSYTTP------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxx-xxxxx----xxx-----SQS xx------------------------------------------------ ----------------------AP-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---LETRGIPFxxxxxxxx---xxxxxxxxx------------------- ------------------------------------------------xx xDQxxxxxxxxxxxxxTELAKxxx-------------------------- -------------------------------------------------- --------------------------------------APH--------- -------------------------------------------RFYTT-V --------------------------------------RPRTSD------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------KPH IRPVL--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------HR xx------------------------------------------------ -------------------------------------------------- -xxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxGMPS----------------xxxxxx------------------- -----------------------------x-------------------- -------------------------------------------------- -----------xxxAxx--------------------------------- -------------------------------------------------- ---------------xSGA---------------xxxxxxDx-------- ---------------------------------------------x-xx- ---------------------------x----------------xx---- -------------------------------------------------- ---------------x---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----GT-----RRPPL---------P-----x------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---RP--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------TPPxRKPLPPx------------------------ ----------------------------------------------NVTG KPG----------------------------------------------- --xxxx-------------------------------------------- -----xxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xPTGxxx-E-------------------R- --IATDI-KQPTV------------------------------------- -------------------------------------------------- -----------PA------------------------------------- -------------------------------------------------- ------------------------------------------------S- GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-LQKPDDSPCSITD SVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTxT-E------------------------------------YEVIS-RE NGSxSG-KNKSIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTV AFSTESADPRVSEPVS----A------GRDAIWTERPFD-S--DSYSECK GKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTG---------------- ------------------------KFYNIGDQRGHGEDHCQFVDSFLDGR TGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSPTEP00000029709 xxxxxx--------------xxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxAL----------------------------------- ----------------------------------------xxxxxx---- ------x-----------K------------------------------- -------------------------------------------------- ----------G--------------------------------------- ------------------------------------K-RPNLKVHINTTS DSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLI NPHHD-WTLPSHCPND-RFYTIRYR--EKxKEKK-WIFQICPATETIVEN LKPNTVYEFGVKDNVEG---GIWSKIFNH--------------------- --------------------K---------------------------TV VG----------xx------------------------------------ ------------KVxxxxQSTYxxxxxV---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------R------------------K-------- -------xxxxTIIKx---------------------------------- -------------------------------VIQNxxxxxxTKSSEKAPL GGVILVHLIIPGLNETT-VKLPA-SLxF-----------EISDALKTQLA KNETLALPAKSKTPEVEKISAR---------------------------- -----------ST---------------TE-------------------- ---------------------------------TxETVPR---------T TKPTTSSALDVSETTL-xVSxRTPETLQTIVIPQFELPLxTL-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------A-----------------PKxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xFPEA----------- -------------------------------------------------- -------------------------------------------------- -----------------KTP------------------------------ -------------------------------------------------- ---------------------------FPFE------------------- -------------------------------------------------- -------------------------------------------------- ---------------KPGGxLAS-SEKPW------------IVPTAKTSE DSKVLQ------------PQx----------------------------- -------------------------------------------------- -------ATYD--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------VFS SPTTSDEPEISESY-TATSDRILD-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------SVP---------------- -------------------------------------PKTSRTLE----- -------------------------------------------------- -----QPRA-----------------------------------T----- --------------LAPR-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------E-TP FVP----------------------------------------------- -------------------------------------------------- -----------------QKLEILTS------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------P---------------AMxPTTP-------------------- -------------APQQ--------------------------------- -------------------------------------------------- ------------STSxPST------------------------------- -----------------------PKRxx---------------------- -----xxxP----------------------------------------- -----------------------------P-------------------- --------------------Rxx--------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------x--------------------- --------------------------------------------xR-TTS AGTITPKISKSPEPTWxxxAxS----------KT---------------- -------------------------------------------------- --------------------QFISLxxxxxxxxxxxxxx----------- -------------xxxxPQ---------------xxxxxxxxxx------ --------------------xxxxx-----------xxx----------- ---------------------------------x-xxxxx-xxxxK---- -----------------------------------xxGx--xx------- ---------------xxx-------------------------------- ---------------xx--------------------------------- -x------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxx------------ -------------------------------------------------- -----------------xxxx----------------------------- -------------------------------------------------- -------------------------------------xxx---------- --------xxx---------xxxxx-------------------xxxxxx xxxxxxxxxS------xxxxxx---------------------------- -------------------------------------xxxxx-------- -----------------------------------------xxxxx---- ------xxxxx----------------------xQLLP-KPQTT------ -----------xEPD--------------MPxxK---------SxxxPVP FETEAPSMTIVPTTxTEPVTVRTEAxxxxxx------------------- ------------------------------------xxTxxxxxTR--x- ---------------xxxx-HKTTPRPET---TQTKLDFGPITPGTSSAP -------------TTTKRx-------------xxPxxxxxxxxxxx---- ---xxxxxx----------------------------xxxxxxx------ ---------------xx-xxxxxxxxxxxPxxP----------------- ---QRT------------------------------------RRPHPKPK xTxxxxxxxxELVPATIFEPVSPIKEAPGxTxV----------------- ----------------------P--------------------------V TDL----------------------------------------------- ------xxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxATTxx-xKTSKRTRxxxxxx--x-xxxxxx AxxxxxVPATxxxPx-------------------xxxPExx-x------- -------------------------------------------------- ------------------------------------------xxxxxTSx xxxxxxxxxxxxxxxxxxxxxxxxxA------------------------ -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxxxxxxxTQAPKxxxxxxxxxxxxxxxxx- ------------------------------------------x------- -------------xxxxxxxxxxTDLEPGTLRTExxxxxxxxxxxxxxxx xxxxxx-xxxxxxx-QRTR-------------xxxx--xxxxx-xxxxxx xxxxxSVTGF------EPVVHSTDAPGTTFAPTDLQTLILKPVTSPSLEM TESQPVSDVLESVTFSTxxxxxTIxxxKxxxxxxxxxxxxxxxxxxxx-V VESVTYVSEP-------------xxx---xxxxxxxxxxSITLx------ ----xxxxxxxx-x------------------------------------ -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -------------------------------------------------- -------------------------------------------------- x------------------------------------------------- ------------------------------xxxxxxxx------------ ------------------xxxxxxx------xxxx--------------- ----------------------------------xxxx------------ ---------------------x-----------xxxx------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxTxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- ----------------------PSPEVSYTTP------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxx-xxxxx----xxx-----SQS xx------------------------------------------------ ----------------------AP-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---LETRGIPFxxxxxxxx---xxxxxxxxx------------------- ------------------------------------------------xx xDQxxxxxxxxxxxxxTELAKxxx-------------------------- -------------------------------------------------- --------------------------------------APH--------- -------------------------------------------RFYTT-V --------------------------------------RPRTSD------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------KPH IRPVL--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------NR xx------------------------------------------------ -------------------------------------------------- -xxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxGMPS----------------xxxxxx------------------- -----------------------------x-------------------- -------------------------------------------------- -----------xxxAxx--------------------------------- -------------------------------------------------- ---------------xSGA---------------xxxxxxDx-------- ---------------------------------------------x-xx- ---------------------------x----------------xx---- -------------------------------------------------- ---------------x---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----GT-----RRPLL---------P-----x------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---RP--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------TPPxRKPLPPx------------------------ ----------------------------------------------NVTG KPG----------------------------------------------- --xxxx-------------------------------------------- -----xxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xPTGxxx-E-------------------R- --IATDI-KQPTV------------------------------------- -------------------------------------------------- -----------PA------------------------------------- -------------------------------------------------- ------------------------------------------------S- GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-LQKPDNSPCSITD SVKRFPK-EDA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTxT-E------------------------------------YEVIS-RE NGSxSG-KNKSIQITNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTV AFSTESADPRVSEPVS----A------GRDAIWTERPFD-S--DSYSECK GKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTG---------------- ------------------------KFYNIGDQRGHGEDHCQFVDSFLDGR TGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSPTRP00000075719 xxxxxx--------------xxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxAL----------------------------------- ----------------------------------------xxxxxx---- ------x-----------K------------------------------- -------------------------------------------------- ----------G--------------------------------------- ------------------------------------K-RPNLKVHINTTS DSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLI NPHHD-WTLPSHCPND-RFYTIRYR--EKxKEKK-WIFQICPATETIVEN LKPNTVYEFGVKDNVEG---GIWSKIFNH--------------------- --------------------K---------------------------TV VG----------xx------------------------------------ ------------KVxxxxQSTYxxxxxV---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------R------------------K-------- -------xxxxTIIKx---------------------------------- -------------------------------VIQNxxxxxxAKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLxF-----------EISDALKTQLA KNETLALPAESKTPEVEKISAR---------------------------- -----------PT---------------TV-------------------- ---------------------------------TxETVPR---------S TKPTTSSALDVSETTL-VLSxRTPETLQTILIPQFELPLxTL-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------A-----------------PKxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xFPEA----------- -------------------------------------------------- -------------------------------------------------- -----------------KTP------------------------------ -------------------------------------------------- ---------------------------FPFE------------------- -------------------------------------------------- -------------------------------------------------- ---------------KPRGxLAS-SEKPW------------IVPTAKISE DSKVLQ------------PQx----------------------------- -------------------------------------------------- -------ATYD--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------VFS SPTTSDEPEISESY-TATSDRILD-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------SIP---------------- -------------------------------------PKTSRTLE----- -------------------------------------------------- -----QPRA-----------------------------------T----- --------------LAPS-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------E-TP FVP----------------------------------------------- -------------------------------------------------- -----------------QKLEIFTS------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------P---------------EMxPTTP-------------------- -------------APQQ--------------------------------- -------------------------------------------------- ------------TTSxPST------------------------------- -----------------------PKRxx---------------------- -----xxxP----------------------------------------- -----------------------------P-------------------- --------------------Rxx--------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------P--------------------- --------------------------------------------xR-TTS AGTITPKISKSPEPTWxxxAxS----------KT---------------- -------------------------------------------------- --------------------QFISLxxxxxxxxxxxxxx----------- -------------xxxxPQ---------------xxxxxxxxxx------ --------------------xxxxx-----------xxx----------- ---------------------------------x--xxxx-xxxxK---- -----------------------------------xxGx--xx------- ---------------xxx-------------------------------- ---------------xx--------------------------------- -x------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxx------------ -------------------------------------------------- -----------------xxxx----------------------------- -------------------------------------------------- -------------------------------------xxx---------- --------xxx---------xxxxx-------------------xxxxxx xxxxxxxxxS------xxxxxx---------------------------- -------------------------------------xxxxx-------- -----------------------------------------xxxxx---- ------xxxxx----------------------xQLLP-KPQTT------ -----------xEPD--------------MPxxK---------SxxxPVP FETEAPSMTIVPTTxIEPVTVRTEAxxxxxx------------------- ------------------------------------xxTxxxxxTR--x- ---------------xxxx-HKTTPRPET---PQTKLDFGPITPGTSSAP ------------xxTTKRx-------------xxPxxxxxxxxxxx---- ---xxxxxx----------------------------xxxxxxx------ ---------------xx-xxxxxxxxxxxPxxP----------------- ---QRT------------------------------------RRPHPKPK xTxxxxxxxxELVPATIFEPVSPIKEAPGTTxV----------------- ----------------------P--------------------------V TDL----------------------------------------------- ------xxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxATTxx-xKTSKRTRxxxxxx--x-xxxxxx AxxxxxVPATxxxPx-------------------xxxPExx-x------- -------------------------------------------------- ------------------------------------------xxxxxTSx xxxxxxxxxxxxxxxxxxxxxxxxxA------------------------ -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxxxxxxxTQAPKxxxxxxxxxxxxxxxxx- ------------------------------------------x------- -------------xxxxxxxxxxTDLEPGTLRTExxxxxxxxxxxxxxxx xxxxxx-xxxxxxx-QRTR-------------xxxx--xxxxx-xxxxxx xxxxxSVTGF------EPVVHSTDAPGTTFAPTELQTLILKPVTSPSLEM TESQPVSDVLESVTFSTxxxxxTIxxxKxxxxxxxxxxxxxxxxxxxx-V VESITYVSEP-------------xxx---xxxxxxxxxxSITLx------ ----xxxxxxxx-x------------------------------------ -------------------------------------------------- -------------------------------------------------- ------x------------------------------------------- -------------------------------------------------- -------------------------------------------------- x------------------------------------------------- ------------------------------xxxxxxxx------------ ------------------xxxxxxx------xxxx--------------- ----------------------------------xxxx------------ ---------------------x-----------xxxx------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxTxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- ----------------------PSPEVSYTTP------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxx-xxxxx----xxx-----SQS xx------------------------------------------------ ----------------------AP-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---LETRGIPFxxxxxxxx---xxxxxxxxx------------------- ------------------------------------------------xx xDQxxxxxxxxxxxxxTELAKxxx-------------------------- -------------------------------------------------- --------------------------------------APH--------- -------------------------------------------RFYTT-V --------------------------------------RPRTSD------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------KPH IRPVL--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------NR xx------------------------------------------------ -------------------------------------------------- -xxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxGMPS----------------xxxxxx------------------- -----------------------------x-------------------- -------------------------------------------------- -----------xxxAxx--------------------------------- -------------------------------------------------- ---------------xSGA---------------xxxxxxDx-------- ---------------------------------------------x-xx- ---------------------------x----------------xx---- -------------------------------------------------- ---------------x---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----GT-----RRPPL---------P-----x------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---RP--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------TPPxRKPLPPx------------------------ ----------------------------------------------NVTG KPG----------------------------------------------- --xxxx-------------------------------------------- -----xxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xPTGxxx-E-------------------R- --IVTDI-KQPTV------------------------------------- -------------------------------------------------- -----------PA------------------------------------- -------------------------------------------------- ------------------------------------------------S- GEE---LENITDFSSSPTRETDPLGKPRFKGPHVRY-IQKPDNSPCSITD SVKRFPK-EEA-TEGNATSPPQNPPTNLTVVTVE-GCPSFVILDWEKPLN DTxT-E------------------------------------YEVIS-RE NGSxSG-KNKSIQMTNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTV AFSTESADPRVSEPVS----A------GRDAIWTERPFN-S--DSYSECK GKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTG---------------- ------------------------KFYNIGDQRGHGEDHCQFVDSFLDGR TGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPG KW >ENSP00000284322 xxxxxx--------------xxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxAL----------------------------------- ----------------------------------------xxxxxx---- ------x-----------K------------------------------- -------------------------------------------------- ----------G--------------------------------------- ------------------------------------K-RPNLKVHINTTS DSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIV--DA EPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLI NPHHD-WTLPSHCPND-RFYTIRYR--EKxKEKK-WIFQICPATETIVEN LKPNTVYEFGVKDNVEG---GIWSKIFNH--------------------- --------------------K---------------------------TV VG----------xx------------------------------------ ------------KVxxxxQSTYxxxxxV---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------R------------------K-------- -------xxPITIIKQ---------------------------------- -------------------------------VIQNxxxxxxAKSPEKAPL GGVILVHLIIPGLNETT-VKLPA-SLxF-----------EISDALKTQLA KNETLALPAESKTPEVEKISAR---------------------------- -----------PT---------------TV-------------------- ---------------------------------TxxTVPR---------S TKPTTSSALDVSET------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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